Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	intramembrane lipid transporter activity	ANO7 ANO2 MFSD2A ANO10	1.46e-06	51	33	4	GO:0140303
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC6A5 CACNA1A CACNA1E ANO7 ANO2 MFSD2A ANO10 PSEN1 ITPR1	2.65e-06	758	33	9	GO:0015318
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC6A5 CACNA1A CACNA1E ANO7 ANO2 MFSD2A ANO10 PSEN1 ITPR1	3.84e-06	793	33	9	GO:0015075
GeneOntologyMolecularFunction	intracellularly calcium-gated channel activity	ANO7 ANO2 ANO10	4.60e-06	20	33	3	GO:0141147
GeneOntologyMolecularFunction	intracellularly calcium-gated chloride channel activity	ANO7 ANO2 ANO10	4.60e-06	20	33	3	GO:0005229
GeneOntologyMolecularFunction	phospholipid transporter activity	ANO7 ANO2 MFSD2A ANO10	6.55e-06	74	33	4	GO:0005548
GeneOntologyMolecularFunction	phospholipid scramblase activity	ANO7 ANO2 ANO10	7.12e-06	23	33	3	GO:0017128
GeneOntologyMolecularFunction	monoatomic ion channel activity	CACNA1A CACNA1E ANO7 ANO2 ANO10 PSEN1 ITPR1	8.25e-06	459	33	7	GO:0005216
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC6A5 CACNA1A CACNA1E ANO7 ANO2 MFSD2A ANO10 IPO8 PSEN1 ITPR1	1.32e-05	1180	33	10	GO:0022857
GeneOntologyMolecularFunction	gated channel activity	CACNA1A CACNA1E ANO7 ANO2 ANO10 ITPR1	1.58e-05	334	33	6	GO:0022836
GeneOntologyMolecularFunction	channel activity	CACNA1A CACNA1E ANO7 ANO2 ANO10 PSEN1 ITPR1	1.97e-05	525	33	7	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CACNA1A CACNA1E ANO7 ANO2 ANO10 PSEN1 ITPR1	1.99e-05	526	33	7	GO:0022803
GeneOntologyMolecularFunction	transporter activity	SLC6A5 CACNA1A CACNA1E ANO7 ANO2 MFSD2A ANO10 IPO8 PSEN1 ITPR1	2.85e-05	1289	33	10	GO:0005215
GeneOntologyMolecularFunction	ATP-dependent activity	MFSD2A DDX60L ACSS2 IPO8 MYO7B DDX60 KIF16B	5.35e-05	614	33	7	GO:0140657
GeneOntologyMolecularFunction	thioredoxin-dependent peroxiredoxin activity	PRDX2 PRDX1	5.53e-05	7	33	2	GO:0140824
GeneOntologyMolecularFunction	thioredoxin peroxidase activity	PRDX2 PRDX1	5.53e-05	7	33	2	GO:0008379
GeneOntologyMolecularFunction	calcium channel activity	CACNA1A CACNA1E PSEN1 ITPR1	5.88e-05	129	33	4	GO:0005262
GeneOntologyMolecularFunction	ligand-gated monoatomic anion channel activity	ANO7 ANO2 ANO10	7.64e-05	50	33	3	GO:0099095
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC6A5 CACNA1A CACNA1E MFSD2A ANO10 PSEN1 ITPR1	8.75e-05	664	33	7	GO:0008324
GeneOntologyMolecularFunction	peroxiredoxin activity	PRDX2 PRDX1	9.47e-05	9	33	2	GO:0051920
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels	CACNA1A CACNA1E	9.47e-05	9	33	2	GO:0099511
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	CACNA1A CACNA1E	9.47e-05	9	33	2	GO:0099626
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC6A5 CACNA1A CACNA1E MFSD2A PSEN1 ITPR1	1.00e-04	465	33	6	GO:0046873
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNA1A CACNA1E PSEN1 ITPR1	1.08e-04	151	33	4	GO:0015085
GeneOntologyMolecularFunction	monoatomic cation channel activity	CACNA1A CACNA1E ANO10 PSEN1 ITPR1	2.32e-04	343	33	5	GO:0005261
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1A CACNA1E	2.38e-04	14	33	2	GO:0008331
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	ANO7 ANO2 ANO10 ITPR1	2.78e-04	193	33	4	GO:0015276
GeneOntologyMolecularFunction	lipid transporter activity	ANO7 ANO2 MFSD2A ANO10	2.95e-04	196	33	4	GO:0005319
GeneOntologyMolecularFunction	ligand-gated channel activity	ANO7 ANO2 ANO10 ITPR1	3.01e-04	197	33	4	GO:0022834
GeneOntologyMolecularFunction	chloride channel activity	ANO7 ANO2 ANO10	3.83e-04	86	33	3	GO:0005254
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC6A5 CACNA1A CACNA1E MFSD2A PSEN1 ITPR1	5.03e-04	627	33	6	GO:0022890
GeneOntologyMolecularFunction	monoatomic anion channel activity	ANO7 ANO2 ANO10	6.50e-04	103	33	3	GO:0005253
GeneOntologyMolecularFunction	chloride transmembrane transporter activity	ANO7 ANO2 ANO10	1.14e-03	125	33	3	GO:0015108
GeneOntologyMolecularFunction	monoatomic anion transmembrane transporter activity	ANO7 ANO2 ANO10	1.96e-03	151	33	3	GO:0008509
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1A CACNA1E	2.62e-03	46	33	2	GO:0005245
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	ANO7 ANO2 ANO10	2.79e-03	171	33	3	GO:0015103
GeneOntologyMolecularFunction	peroxidase activity	PRDX2 PRDX1	5.16e-03	65	33	2	GO:0004601
GeneOntologyMolecularFunction	oxidoreductase activity, acting on peroxide as acceptor	PRDX2 PRDX1	5.48e-03	67	33	2	GO:0016684
GeneOntologyMolecularFunction	RNA helicase activity	DDX60L DDX60	7.35e-03	78	33	2	GO:0003724
GeneOntologyMolecularFunction	double-stranded RNA binding	DDX60L DDX60	7.35e-03	78	33	2	GO:0003725
GeneOntologyMolecularFunction	ATP-dependent activity, acting on RNA	DDX60L DDX60	7.72e-03	80	33	2	GO:0008186
GeneOntologyMolecularFunction	solute:sodium symporter activity	SLC6A5 MFSD2A	7.91e-03	81	33	2	GO:0015370
GeneOntologyMolecularFunction	antioxidant activity	PRDX2 PRDX1	1.12e-02	97	33	2	GO:0016209
GeneOntologyMolecularFunction	phospholipid binding	LPAR4 CPNE7 ITPR1 KIF16B	1.22e-02	548	33	4	GO:0005543
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	SLC6A5 CACNA1A CACNA1E ANO7 ANO2 PLCG1 ANO10 PSEN1 ITPR1	2.19e-05	1017	33	9	GO:0098660
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	SLC6A5 CACNA1A CACNA1E ANO7 ANO2 PLCG1 ANO10 PSEN1 ITPR1	4.53e-05	1115	33	9	GO:0034220
GeneOntologyCellularComponent	presynaptic membrane	SLC6A5 CACNA1A CACNA1E ANO2 PSEN1	6.90e-05	277	33	5	GO:0042734
GeneOntologyCellularComponent	synaptic membrane	SLC6A5 CACNA1A CACNA1E ANO2 PSEN1 ITPR1	2.67e-04	583	33	6	GO:0097060
HumanPheno	Dyscalculia	CACNA1A PSEN1 ITPR1	1.97e-05	24	12	3	HP:0002442
Domain	Anoctamin	ANO7 ANO2 ANO10	5.44e-07	10	32	3	PF04547
Domain	Anoctamin	ANO7 ANO2 ANO10	5.44e-07	10	32	3	IPR007632
Domain	Peroxiredoxin_AhpC-typ	PRDX2 PRDX1	8.52e-06	3	32	2	IPR024706
Domain	1-cysPrx_C	PRDX2 PRDX1	2.83e-05	5	32	2	PF10417
Domain	Peroxiredoxin_C	PRDX2 PRDX1	2.83e-05	5	32	2	IPR019479
Domain	GPHH_dom	CACNA1A CACNA1E	5.94e-05	7	32	2	IPR031649
Domain	VDCC_a1su_IQ	CACNA1A CACNA1E	5.94e-05	7	32	2	IPR014873
Domain	Anoct_dimer	ANO7 ANO2	5.94e-05	7	32	2	PF16178
Domain	Anoct_dimer	ANO7 ANO2	5.94e-05	7	32	2	IPR032394
Domain	Ca_chan_IQ	CACNA1A CACNA1E	5.94e-05	7	32	2	SM01062
Domain	Ca_chan_IQ	CACNA1A CACNA1E	5.94e-05	7	32	2	PF08763
Domain	GPHH	CACNA1A CACNA1E	5.94e-05	7	32	2	PF16905
Domain	AhpC/TSA	PRDX2 PRDX1	5.94e-05	7	32	2	IPR000866
Domain	AhpC-TSA	PRDX2 PRDX1	5.94e-05	7	32	2	PF00578
Domain	VDCCAlpha1	CACNA1A CACNA1E	1.27e-04	10	32	2	IPR002077
Domain	Ion_trans_dom	CACNA1A CACNA1E ITPR1	9.66e-04	114	32	3	IPR005821
Domain	Ion_trans	CACNA1A CACNA1E ITPR1	9.66e-04	114	32	3	PF00520
Domain	-	PRDX2 TXNL4B PRDX1	1.17e-03	122	32	3	3.40.30.10
Domain	Thioredoxin-like_fold	PRDX2 TXNL4B PRDX1	1.47e-03	132	32	3	IPR012336
Domain	Thioredoxin_domain	PRDX2 PRDX1	2.24e-03	41	32	2	IPR013766
Domain	THIOREDOXIN_2	PRDX2 PRDX1	2.46e-03	43	32	2	PS51352
Domain	Channel_four-helix_dom	CACNA1A CACNA1E	4.28e-03	57	32	2	IPR027359
Domain	-	CACNA1A CACNA1E	4.28e-03	57	32	2	1.20.120.350
Domain	DEAD	DDX60L DDX60	6.93e-03	73	32	2	PF00270
Domain	DEAD/DEAH_box_helicase_dom	DDX60L DDX60	6.93e-03	73	32	2	IPR011545
Domain	MFS	MFSD2A MFSD6	7.68e-03	77	32	2	IPR011701
Domain	MFS_1	MFSD2A MFSD6	7.68e-03	77	32	2	PF07690
Domain	Helicase_C	DDX60L DDX60	1.44e-02	107	32	2	PF00271
Domain	HELICc	DDX60L DDX60	1.44e-02	107	32	2	SM00490
Domain	Helicase_C	DDX60L DDX60	1.47e-02	108	32	2	IPR001650
Domain	MFS	MFSD2A MFSD6	1.47e-02	108	32	2	PS50850
Domain	HELICASE_CTER	DDX60L DDX60	1.49e-02	109	32	2	PS51194
Domain	HELICASE_ATP_BIND_1	DDX60L DDX60	1.49e-02	109	32	2	PS51192
Domain	DEXDc	DDX60L DDX60	1.49e-02	109	32	2	SM00487
Domain	Helicase_ATP-bd	DDX60L DDX60	1.52e-02	110	32	2	IPR014001
Pathway	REACTOME_INDUCTION_OF_CELL_CELL_FUSION	ANO7 ANO2 ANO10	1.23e-06	13	24	3	M46426
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY	PLCG1 ITPR1	2.77e-05	5	24	2	M49000
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	CACNA1A CACNA1E ITPR1	1.46e-04	61	24	3	MM15071
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY	CACNA1A CACNA1E	1.51e-04	11	24	2	M47958
Pathway	REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING	CACNA1A CACNA1E	1.51e-04	11	24	2	MM14498
Pathway	REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING	CACNA1A CACNA1E	1.51e-04	11	24	2	M26913
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	PSEN1 ITPR1	2.14e-04	13	24	2	M47696
Pathway	KEGG_CALCIUM_SIGNALING_PATHWAY	CACNA1A CACNA1E PLCG1 ITPR1	2.14e-04	178	24	4	M2890
Pathway	REACTOME_LATE_SARS_COV_2_INFECTION_EVENTS	ANO7 ANO2 ANO10	2.20e-04	70	24	3	M46438
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	CACNA1A CACNA1E ITPR1	2.39e-04	72	24	3	MM14631
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	CACNA1A CACNA1E ITPR1	3.03e-04	78	24	3	M1921
Pathway	WP_MFAP5_EFFECT_ON_PERMEABILITY_AND_MOTILITY_OF_ENDOTHELIAL_CELLS_VIA_CYTOSKELETON_REARRANGEMENT	PLCG1 ITPR1	4.18e-04	18	24	2	M39808
Pathway	REACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION	PLCG1 ITPR1	4.67e-04	19	24	2	M27423
Pathway	KEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY	PLCG1 ITPR1	4.67e-04	19	24	2	M47733
Pathway	WP_OXIDATIVE_STRESS_AND_REDOX_PATHWAY	SLC6A5 PRDX2 PRDX1	4.93e-04	92	24	3	MM15823
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	ANO7 ANO2 ANO10	6.11e-04	99	24	3	MM14910
Pathway	WP_PKCGAMMA_CALCIUM_SIGNALING_IN_ATAXIA	CACNA1A ITPR1	6.28e-04	22	24	2	M39795
Pathway	KEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1A CACNA1E	6.88e-04	23	24	2	M47666
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	ANO7 ANO2 ANO10	7.46e-04	106	24	3	M27200
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	CACNA1A CACNA1E ITPR1	7.87e-04	108	24	3	M17034
Pathway	REACTOME_DEFECTIVE_INTRINSIC_PATHWAY_FOR_APOPTOSIS	PRDX2 PRDX1	8.14e-04	25	24	2	M42527
Pathway	KEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL	CACNA1A CACNA1E	8.14e-04	25	24	2	M47948
Pathway	WP_RESISTIN_AS_A_REGULATOR_OF_INFLAMMATION	PLCG1 ITPR1	1.42e-03	33	24	2	M39745
Pathway	REACTOME_DETOXIFICATION_OF_REACTIVE_OXYGEN_SPECIES	PRDX2 PRDX1	1.60e-03	35	24	2	MM14944
Pathway	REACTOME_DETOXIFICATION_OF_REACTIVE_OXYGEN_SPECIES	PRDX2 PRDX1	1.78e-03	37	24	2	M27244
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	CACNA1A CACNA1E ITPR1	1.91e-03	147	24	3	MM15854
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	CACNA1A CACNA1E ITPR1	2.07e-03	151	24	3	M39329
Pathway	REACTOME_DAG_AND_IP3_SIGNALING	PLCG1 ITPR1	2.19e-03	41	24	2	M512
Pubmed	ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins.	ANO7 ANO2 ANO10	2.72e-08	7	33	3	22075693
Pubmed	The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels.	ANO7 ANO2 ANO10	4.34e-08	8	33	3	21984732
Pubmed	Expression and function of epithelial anoctamins.	ANO7 ANO2 ANO10	4.34e-08	8	33	3	20056604
Pubmed	Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels.	ANO7 ANO2 ANO10	9.30e-08	10	33	3	19015192
Pubmed	Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members.	ANO7 ANO2 ANO10	9.30e-08	10	33	3	23532839
Pubmed	Structure and function of TMEM16 proteins (anoctamins).	ANO7 ANO2 ANO10	9.30e-08	10	33	3	24692353
Pubmed	Overexpression of peroxiredoxin in human breast cancer.	PRDX2 PRDX1	8.73e-07	2	33	2	11497302
Pubmed	HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family.	PRDX2 PRDX1	8.73e-07	2	33	2	12421812
Pubmed	Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma.	PRDX2 PRDX1	8.73e-07	2	33	2	26636537
Pubmed	Peroxiredoxin I deficiency increases pancreatic β‑cell apoptosis after streptozotocin stimulation via the AKT/GSK3β signaling pathway.	PRDX2 PRDX1	8.73e-07	2	33	2	32705184
Pubmed	The gain-of-function enhancement of IP3-receptor channel gating by familial Alzheimer's disease-linked presenilin mutants increases the open probability of mitochondrial permeability transition pore.	PSEN1 ITPR1	8.73e-07	2	33	2	27184076
Pubmed	Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress.	PRDX2 PRDX1	8.73e-07	2	33	2	23101509
Pubmed	Dominant role of peroxiredoxin/JNK axis in stemness regulation during neurogenesis from embryonic stem cells.	PRDX2 PRDX1	8.73e-07	2	33	2	24715692
Pubmed	Peroxiredoxin I and II in human eyes: cellular distribution and association with pterygium and DNA damage.	PRDX2 PRDX1	8.73e-07	2	33	2	24152995
Pubmed	Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells.	PRDX2 PRDX1	8.73e-07	2	33	2	22902630
Pubmed	Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis.	PSEN1 ITPR1	8.73e-07	2	33	2	24828645
Pubmed	Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins.	PRDX2 PRDX1	8.73e-07	2	33	2	29884768
Pubmed	Compensatory contribution of Cav2.3 channels to acetylcholine release at the neuromuscular junction of tottering mice.	CACNA1A CACNA1E	8.73e-07	2	33	2	16381801
Pubmed	Peroxiredoxin as a functional endogenous antioxidant enzyme in pronuclei of mouse zygotes.	PRDX2 PRDX1	8.73e-07	2	33	2	29503398
Pubmed	Urate hydroperoxide oxidizes human peroxiredoxin 1 and peroxiredoxin 2.	PRDX2 PRDX1	8.73e-07	2	33	2	28348082
Pubmed	Human Peroxiredoxins 1 and 2 and Their Interacting Protein Partners; Through Structure Toward Functions of Biological Complexes.	PRDX2 PRDX1	8.73e-07	2	33	2	26548861
Pubmed	Peroxiredoxin I and II are up-regulated during differentiation of epidermal keratinocytes.	PRDX2 PRDX1	8.73e-07	2	33	2	15864612
Pubmed	Deciphering the in vivo redox behavior of human peroxiredoxins I and II by expressing in budding yeast.	PRDX2 PRDX1	8.73e-07	2	33	2	31580947
Pubmed	Differential parameters between cytosolic 2-Cys peroxiredoxins, PRDX1 and PRDX2.	PRDX2 PRDX1	8.73e-07	2	33	2	30284335
Pubmed	Regeneration of peroxiredoxins during recovery after oxidative stress: only some overoxidized peroxiredoxins can be reduced during recovery after oxidative stress.	PRDX2 PRDX1	8.73e-07	2	33	2	12853451
Pubmed	Peroxiredoxin-mediated disulfide bond formation is required for nucleocytoplasmic translocation and secretion of HMGB1 in response to inflammatory stimuli.	PRDX2 PRDX1	8.73e-07	2	33	2	31026770
Pubmed	Novel protective mechanism against irreversible hyperoxidation of peroxiredoxin: Nalpha-terminal acetylation of human peroxiredoxin II.	PRDX2 PRDX1	8.73e-07	2	33	2	19286652
Pubmed	Peroxiredoxin expression and redox status in neutrophils and HL-60 cells.	PRDX2 PRDX1	8.73e-07	2	33	2	30862546
Pubmed	Peroxiredoxin Expression of Human Osteosarcoma Cells Is Influenced by Cold Atmospheric Plasma Treatment.	PRDX2 PRDX1	8.73e-07	2	33	2	28314261
Pubmed	Oxidative and nitrosative stress induces peroxiredoxins in pancreatic beta cells.	PRDX2 PRDX1	8.73e-07	2	33	2	12107731
Pubmed	Calcium-binding protein 1 is an inhibitor of agonist-evoked, inositol 1,4,5-trisphosphate-mediated calcium signaling.	CACNA1A ITPR1	2.62e-06	3	33	2	14570872
Pubmed	Polypeptides differentially expressed in imaginal discs define the peroxiredoxin family of genes in Drosophila.	PRDX2 PRDX1	2.62e-06	3	33	2	10632718
Pubmed	The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.	CACNA1A CACNA1E	2.62e-06	3	33	2	38996073
Pubmed	Polymorphisms of peroxiredoxin 1, 2 and 6 are not associated with esophageal cancer.	PRDX2 PRDX1	2.62e-06	3	33	2	22215146
Pubmed	Peroxiredoxin II is an essential antioxidant enzyme that prevents the oxidative inactivation of VEGF receptor-2 in vascular endothelial cells.	PRDX2 PRDX1	2.62e-06	3	33	2	22099303
Pubmed	Human peroxiredoxin 1 and 2 are not duplicate proteins: the unique presence of CYS83 in Prx1 underscores the structural and functional differences between Prx1 and Prx2.	PRDX2 PRDX1	2.62e-06	3	33	2	17519234
Pubmed	Structural and biochemical analyses reveal ubiquitin C-terminal hydrolase-L1 as a specific client of the peroxiredoxin II chaperone.	PRDX2 PRDX1	2.62e-06	3	33	2	29339092
Pubmed	Crucial role of peroxiredoxin III in placental antioxidant defense of mice.	PRDX2 PRDX1	2.62e-06	3	33	2	18544346
Pubmed	Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells.	PRDX2 PRDX1	2.62e-06	3	33	2	28659575
Pubmed	Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate.	PRDX2 PRDX1	2.62e-06	3	33	2	10751410
Pubmed	Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+ signaling.	PSEN1 ITPR1	2.62e-06	3	33	2	21784978
Pubmed	Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II.	PLCG1 PRDX2	2.62e-06	3	33	2	15902258
Pubmed	Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome.	PRDX2 PRDX1	2.62e-06	3	33	2	11771746
Pubmed	Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.	CACNA1A CACNA1E	2.62e-06	3	33	2	24523520
Pubmed	HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation.	PRDX2 PRDX1	2.62e-06	3	33	2	18606987
Pubmed	Requirement of biphasic calcium release from the endoplasmic reticulum for Fas-mediated apoptosis.	PLCG1 ITPR1	2.62e-06	3	33	2	17130290
Pubmed	Regulation of peroxiredoxin I activity by Cdc2-mediated phosphorylation.	PRDX2 PRDX1	2.62e-06	3	33	2	11986303
Pubmed	Cloning and sequence analysis of candidate human natural killer-enhancing factor genes.	PRDX2 PRDX1	2.62e-06	3	33	2	8026862
Pubmed	PLCγ1-PKCε-IP3R1 signaling plays an important role in hypoxia-induced calcium response in pulmonary artery smooth muscle cells.	PLCG1 ITPR1	2.62e-06	3	33	2	29388468
Pubmed	Evolution and functional divergence of the anoctamin family of membrane proteins.	ANO7 ANO10	2.62e-06	3	33	2	20964844
Pubmed	Peroxiredoxins and tropomyosins as plasma biomarkers for lung cancer and asbestos exposure.	PRDX2 PRDX1	2.62e-06	3	33	2	22537621
Pubmed	Expression of thioredoxin 1 and peroxiredoxins in squamous cervical carcinoma and its predictive role in NACT.	PRDX2 PRDX1	2.62e-06	3	33	2	31470801
Pubmed	Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site.	PRDX2 PRDX1	2.62e-06	3	33	2	11904290
Pubmed	Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.	CACNA1A CACNA1E	5.23e-06	4	33	2	32616470
Pubmed	Cerebellar granule cell signaling is indispensable for normal motor performance.	CACNA1A CACNA1E	5.23e-06	4	33	2	37141091
Pubmed	Expression of peroxiredoxin 1, 2, 3, and 6 genes in cancer cells during drug resistance formation.	PRDX2 PRDX1	5.23e-06	4	33	2	23113308
Pubmed	Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD.	PRDX2 PRDX1	5.23e-06	4	33	2	15105503
Pubmed	Nonredundant antioxidant defense by multiple two-cysteine peroxiredoxins in human prostate cancer cells.	PRDX2 PRDX1	5.23e-06	4	33	2	12080185
Pubmed	Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders.	PRDX2 PRDX1	5.23e-06	4	33	2	12650976
Pubmed	Genetic mapping of six mouse peroxiredoxin genes and fourteen peroxiredoxin related sequences.	CACNA1E PRDX2 PRDX1	6.42e-06	38	33	3	10501973
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNA1A CACNA1E ITPR1	6.42e-06	38	33	3	30786075
Pubmed	Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.	CACNA1A CACNA1E	8.72e-06	5	33	2	8825650
Pubmed	Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.	CACNA1A CACNA1E	8.72e-06	5	33	2	11296258
Pubmed	Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.	CACNA1A CACNA1E	8.72e-06	5	33	2	15451373
Pubmed	Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.	PLCG1 ITPR1	1.31e-05	6	33	2	21762810
Pubmed	An action potential initiation mechanism in distal axons for the control of dopamine release.	CACNA1A CACNA1E	1.31e-05	6	33	2	35324301
Pubmed	Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.	CACNA1A CACNA1E	1.31e-05	6	33	2	9238069
Pubmed	Glutathione reductase deficiency alters lung development and hyperoxic responses in neonatal mice.	PRDX2 PRDX1	1.31e-05	6	33	2	33254076
Pubmed	Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.	CACNA1A CACNA1E	1.31e-05	6	33	2	12827191
Pubmed	Rebuilding essential active zone functions within a synapse.	CACNA1A CACNA1E	1.83e-05	7	33	2	35176221
Pubmed	Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro.	PRDX2 PRDX1	1.83e-05	7	33	2	10514471
Pubmed	Expression of TMEM16 paralogs during murine embryogenesis.	ANO2 ANO10	2.44e-05	8	33	2	18729231
Pubmed	Anoctamins are a family of Ca2+-activated Cl- channels.	ANO7 ANO10	2.44e-05	8	33	2	22946059
Pubmed	PRDX6 Inhibits Neurogenesis through Downregulation of WDFY1-Mediated TLR4 Signal.	PRDX2 PRDX1	3.13e-05	9	33	2	30097850
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1A CACNA1E	3.13e-05	9	33	2	16382099
Pubmed	Genetics of dizziness: cerebellar and vestibular disorders.	CACNA1A ANO10	3.13e-05	9	33	2	24275721
Pubmed	Comparative proteomic analysis identifies protein disulfide isomerase and peroxiredoxin 1 as new players involved in embryonic interdigital cell death.	PRDX2 PRDX1	3.13e-05	9	33	2	15858817
Pubmed	Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors.	PRDX2 PRDX1	3.91e-05	10	33	2	17141802
Pubmed	Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders.	SLC6A5 CACNA1A ITPR1	4.44e-05	72	33	3	25917818
Pubmed	Identification of epilepsy genes in human and mouse.	CACNA1A ITPR1	5.73e-05	12	33	2	11700294
Pubmed	The antioxidant enzyme Prdx1 controls neuronal differentiation by thiol-redox-dependent activation of GDE2.	PRDX2 PRDX1	6.77e-05	13	33	2	19766572
Pubmed	Expression of peroxiredoxins and thioredoxins in the mouse spinal cord during embryonic development.	PRDX2 PRDX1	6.77e-05	13	33	2	25975898
Pubmed	Ubiquitin-dependent degradation of CDK2 drives the therapeutic differentiation of AML by targeting PRDX2.	PRDX2 PRDX1	7.89e-05	14	33	2	29720484
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA1A CACNA1E	9.10e-05	15	33	2	20188150
Pubmed	Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.	CACNA1A CACNA1E	9.10e-05	15	33	2	24453333
Pubmed	Hereditary Ataxia Overview	CACNA1A ANO10 ITPR1	9.23e-05	92	33	3	20301317
Pubmed	Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice.	ANO2 ZFHX4	1.04e-04	16	33	2	16096065
Pubmed	Effects of thioredoxin reductase-1 deletion on embryogenesis and transcriptome.	PRDX2 PRDX1	2.38e-04	24	33	2	17697936
Pubmed	Proteomic analysis of the palmitoyl protein thioesterase 1 interactome in SH-SY5Y human neuroblastoma cells.	PRDX2 PRDX1	2.38e-04	24	33	2	25865307
Pubmed	Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.	PLCG1 ITPR1	2.38e-04	24	33	2	10843712
Pubmed	The tumor suppressor PP2A Abeta regulates the RalA GTPase.	PRDX2 PRDX1	4.25e-04	32	33	2	17540176
Pubmed	Streamline proteomic approach for characterizing protein-protein interaction network in a RAD52 protein complex.	PRDX2 PRDX1	4.25e-04	32	33	2	19338310
Pubmed	Tandem immunoprecipitation of phosphotyrosine-mass spectrometry (TIPY-MS) indicates C19ORF19 becomes tyrosine-phosphorylated and associated with activated epidermal growth factor receptor.	DDX60 PRDX1	4.53e-04	33	33	2	18271526
Pubmed	Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages.	PRDX2 PRDX1	5.69e-04	37	33	2	34225486
Pubmed	Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.	DNAJB7 PSEN1 MYO7B	5.72e-04	171	33	3	28700664
Pubmed	Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease.	PLCG1 PRDX2 IPO8 PRDX1	6.39e-04	418	33	4	32552912
Pubmed	Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation.	CACNA1A ITPR1	8.80e-04	46	33	2	34815492
Pubmed	TrkB-dependent EphrinA reverse signaling regulates callosal axon fasciculate growth downstream of Neurod2/6.	PLCG1 PLXNA1	9.19e-04	47	33	2	35462405
Interaction	ANO2 interactions	ANO7 ANO2	2.44e-05	5	32	2	int:ANO2
Cytoband	4q32.3	DDX60L DDX60	2.77e-04	34	33	2	4q32.3
GeneFamily	Anoctamins	ANO7 ANO2 ANO10	2.45e-07	10	24	3	865
GeneFamily	Peroxiredoxins	PRDX2 PRDX1	2.52e-05	6	24	2	953
GeneFamily	Calcium voltage-gated channel subunits	CACNA1A CACNA1E	5.38e-04	26	24	2	253
Coexpression	GSE10147_IL3_VS_IL3_AND_CPG_STIM_PDC_DN	DNAJB7 IPO8 PLXNA1 KIF16B	5.37e-05	165	33	4	M353
Coexpression	FAN_EMBRYONIC_CTX_EX_4_EXCITATORY_NEURON	CACNA1A CACNA1E CPNE7 ITPR1	5.50e-05	166	33	4	M39026
Coexpression	GSE21360_NAIVE_VS_SECONDARY_MEMORY_CD8_TCELL_DN	CACNA1A ACSS2 PLXNA1 DDX60	7.06e-05	177	33	4	M7632
Coexpression	GSE45365_WT_VS_IFNAR_KO_BCELL_UP	DNAJB7 ACSS2 PSEN1 KIF16B	1.03e-04	195	33	4	M9984
Coexpression	GSE2706_UNSTIM_VS_8H_LPS_AND_R848_DC_DN	MFSD2A DDX60L TXNL4B DDX60	1.07e-04	197	33	4	M4705
Coexpression	GSE13485_PRE_VS_POST_YF17D_VACCINATION_PBMC_DN	DDX60L IPO8 DDX60 KIF16B	1.11e-04	199	33	4	M3311
Drug	isradipine	CACNA1A CACNA1E PRDX2 PSEN1 ITPR1	2.71e-07	100	32	5	CID000003784
Drug	pentasulfane	CACNA1A CACNA1E PSEN1	1.39e-06	16	32	3	CID000448216
Drug	Cefuroxime sodium salt [56238-63-2]; Down 200; 9uM; HL60; HT_HG-U133A	CACNA1A PRDX2 ANO10 IPO8 PLXNA1	7.68e-06	197	32	5	2526_DN
Drug	AC 110	CACNA1A CACNA1E	1.15e-05	4	32	2	CID000022860
Drug	2-acetylamino-3-(4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)phenylthiocarbamoylsulfanyl)propionic acid	PRDX2 PRDX1	1.15e-05	4	32	2	ctd:C539612
Drug	CT-2584	PRDX2 PRDX1	1.15e-05	4	32	2	CID003081346
Drug	CNS 1145	CACNA1A CACNA1E ITPR1	1.34e-05	33	32	3	CID000190902
Drug	IHC-64	CACNA1A CACNA1E ITPR1	1.34e-05	33	32	3	CID000162753
Drug	3,4-dihydroquinazoline	CACNA1A CACNA1E	2.86e-05	6	32	2	CID000583065
Drug	alpha-sialylcholesterol	CACNA1A CACNA1E	2.86e-05	6	32	2	CID000133976
Drug	APMPA	CACNA1A CACNA1E	4.00e-05	7	32	2	CID000512300
Drug	Dantrolene-13C3	CACNA1A CACNA1E PSEN1 ITPR1	4.94e-05	145	32	4	CID000002951
Drug	Bay K 8644	CACNA1A CACNA1E PRDX2 ITPR1	5.64e-05	150	32	4	CID000002303
Drug	Cinildipine	CACNA1A CACNA1E ITPR1	6.65e-05	56	32	3	CID000002752
Drug	nilvadipine	CACNA1A CACNA1E ITPR1	8.17e-05	60	32	3	CID000004494
Drug	IAA-94	CACNA1A CACNA1E ITPR1	8.59e-05	61	32	3	CID000003667
Drug	lercanidipine	CACNA1A CACNA1E ITPR1	9.46e-05	63	32	3	CID000065866
Drug	(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate	PRDX2 PRDX1	1.04e-04	11	32	2	ctd:C423264
Drug	leys	CACNA1A CACNA1E	1.04e-04	11	32	2	CID000484683
Drug	papaverine	CACNA1A CACNA1E PLCG1 ITPR1	1.05e-04	176	32	4	CID000004680
Drug	gallopamil	CACNA1A CACNA1E ITPR1	1.14e-04	67	32	3	CID000001234
Drug	AC1L2AC7	CACNA1A CACNA1E ITPR1	1.24e-04	69	32	3	CID000068733
Drug	AC1L2VU3	CACNA1A CACNA1E	1.25e-04	12	32	2	CID000129572
Drug	Chlorambucil [305-03-3]; Down 200; 13.2uM; PC3; HT_HG-U133A	PLCG1 IPO8 MFSD6 ITPR1	1.38e-04	189	32	4	3788_DN
Drug	retinoic acid; Up 200; 1uM; PC3; HT_HG-U133A	URB1 PLCG1 IPO8 CPNE7	1.44e-04	191	32	4	1211_UP
Drug	Methionine sulfoximine (L) [15985-39-4]; Up 200; 22.2uM; MCF7; HT_HG-U133A	PRDX2 LPAR4 ZFHX4 ITPR1	1.47e-04	192	32	4	2831_UP
Drug	CAS 298-57-7	CACNA1A CACNA1E ITPR1	1.47e-04	73	32	3	CID000002761
Drug	triclopyr	PRDX2 PRDX1	1.48e-04	13	32	2	ctd:C032742
Drug	Picloram	PRDX2 PRDX1	1.48e-04	13	32	2	ctd:D010846
Drug	Amyleine hydrochloride [532-59-2]; Down 200; 14.8uM; MCF7; HT_HG-U133A	CACNA1A PLCG1 ZFHX4 ITPR1	1.52e-04	194	32	4	4169_DN
Drug	ethosuximide	CACNA1A CACNA1E ITPR1	1.53e-04	74	32	3	CID000003291
Drug	Phentolamine hydrochloride [73-05-2]; Up 200; 12.6uM; MCF7; HT_HG-U133A	ANO2 DDX60 MFSD6 CPNE7	1.55e-04	195	32	4	3860_UP
Drug	Cimetidine [51481-61-9]; Up 200; 15.8uM; PC3; HG-U133A	CACNA1A PLCG1 PRDX2 CPNE7	1.55e-04	195	32	4	1884_UP
Drug	Proglumide [6620-60-6]; Down 200; 12uM; MCF7; HT_HG-U133A	CACNA1A PLCG1 IPO8 MFSD6	1.55e-04	195	32	4	3972_DN
Drug	Gossypol [303-45-7]; Down 200; 7.8uM; MCF7; HT_HG-U133A	CACNA1A ZFHX4 CPNE7 ITPR1	1.59e-04	196	32	4	3637_DN
Drug	Benzocaine [94-09-7]; Up 200; 24.2uM; MCF7; HT_HG-U133A	CACNA1A LPAR4 ZFHX4 CPNE7	1.59e-04	196	32	4	4808_UP
Drug	Ifenprodil tartrate [23210-58-4]; Down 200; 8.4uM; HL60; HT_HG-U133A	ANO10 PSEN1 PLXNA1 DDX60	1.59e-04	196	32	4	2372_DN
Drug	Ofloxacin [82419-36-1]; Down 200; 11uM; PC3; HT_HG-U133A	URB1 PLCG1 DDX60 ITPR1	1.59e-04	196	32	4	3673_DN
Drug	Tiaprofenic acid [33005-95-7]; Down 200; 15.4uM; PC3; HT_HG-U133A	PLCG1 IPO8 MFSD6 ITPR1	1.62e-04	197	32	4	4091_DN
Drug	Conessine [546-06-5]; Up 200; 11.2uM; MCF7; HT_HG-U133A	ANO2 PRDX2 MFSD6 ITPR1	1.62e-04	197	32	4	2792_UP
Drug	Dirithromycin [62013-04-1]; Up 200; 4.8uM; HL60; HG-U133A	CACNA1A PLCG1 PLXNA1 CPNE7	1.65e-04	198	32	4	1712_UP
Drug	Tracazolate hydrochloride [41094-88-6]; Up 200; 11.8uM; MCF7; HT_HG-U133A	PLCG1 LPAR4 ZFHX4 DDX60	1.65e-04	198	32	4	4964_UP
Drug	Ranitidine hydrochloride [66357-59-3]; Up 200; 11.4uM; MCF7; HT_HG-U133A	LPAR4 PLXNA1 MFSD6 ITPR1	1.65e-04	198	32	4	5425_UP
Drug	6-Furfurylaminopurine [525-79-1]; Up 200; 18.6uM; MCF7; HT_HG-U133A	URB1 LPAR4 MFSD6 ITPR1	1.65e-04	198	32	4	6073_UP
Drug	Yohimbine hydrochloride [65-19-0]; Up 200; 10.2uM; MCF7; HT_HG-U133A	PLCG1 MFSD6 ITPR1 KIF16B	1.65e-04	198	32	4	2755_UP
Drug	Thioperamide maleate [106243-16-7]; Up 200; 9.8uM; MCF7; HT_HG-U133A	CCR8 ZFHX4 MFSD6 ITPR1	1.65e-04	198	32	4	5635_UP
Drug	Pentetic acid [67-43-6]; Up 200; 10.2uM; MCF7; HT_HG-U133A	DDX60 MFSD6 CPNE7 ITPR1	1.68e-04	199	32	4	5264_UP
Drug	Thiethylperazine malate [52239-63-1]; Down 200; 6uM; PC3; HT_HG-U133A	URB1 PLCG1 PRDX2 MFSD6	1.68e-04	199	32	4	5756_DN
Drug	Guanadrel sulfate [22195-34-2]; Down 200; 7.6uM; PC3; HT_HG-U133A	URB1 PLCG1 PLXNA1 CPNE7	1.68e-04	199	32	4	3698_DN
Drug	Nortriptyline hydrochloride [894-71-3]; Down 200; 13.4uM; HL60; HT_HG-U133A	PRDX2 IPO8 PLXNA1 CPNE7	1.68e-04	199	32	4	2391_DN
Drug	Adiphenine hydrochloride [50-42-0]; Down 200; 11.4uM; HL60; HT_HG-U133A	PLCG1 PRDX2 LPAR4 CPNE7	1.71e-04	200	32	4	1872_DN
Drug	Dipyrone [5907-38-0]; Down 200; 12uM; HL60; HT_HG-U133A	CACNA1A URB1 PLCG1 DDX60	1.71e-04	200	32	4	2175_DN
Drug	nordihydroguaiaretic acid; Up 200; 1uM; PC3; HT_HG-U133A	ANO2 PLCG1 LPAR4 CPNE7	1.71e-04	200	32	4	4447_UP
Drug	thioridazine hydrochloride; Down 200; 10uM; PC3; HT_HG-U133A	URB1 PLCG1 PSEN1 ITPR1	1.71e-04	200	32	4	5921_DN
Drug	stearylsilane	CACNA1A DNAJB7	1.72e-04	14	32	2	CID000087730
Drug	arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide	PRDX2 PRDX1	1.72e-04	14	32	2	ctd:C506540
Drug	nisoldipine	CACNA1A CACNA1E ITPR1	1.79e-04	78	32	3	CID000004499
Drug	N-cyclopentyl-N-cyclobutylformamide	CACNA1A CACNA1E ITPR1	1.85e-04	79	32	3	CID005287890
Drug	butamben	CACNA1A CACNA1E	1.99e-04	15	32	2	CID000002482
Drug	XeC compound	CACNA1E PSEN1 ITPR1	2.22e-04	84	32	3	CID000005701
Drug	reactive blue 2	CACNA1E PLCG1 LPAR4	2.47e-04	87	32	3	CID000656725
Drug	AC1L9NBR	ANO2 PRDX2 PSEN1	2.91e-04	92	32	3	CID000449625
Drug	3-(1H-pyrrole-2-carboxylate	CACNA1A CACNA1E PSEN1 ITPR1	3.07e-04	233	32	4	CID000005114
Drug	manidipine	CACNA1A CACNA1E ITPR1	3.20e-04	95	32	3	CID000004008
Drug	N6-Me-dAdo	CACNA1A CACNA1E	3.22e-04	19	32	2	CID000168948
Drug	pranidipine	CACNA1A CACNA1E	3.22e-04	19	32	2	CID006436048
Drug	ADP beta S	CACNA1E PLCG1 LPAR4	3.30e-04	96	32	3	CID005310996
Drug	isotetrandrine	CACNA1A CACNA1E ITPR1	3.40e-04	97	32	3	CID000005422
Drug	nitrendipine	CACNA1A CACNA1E ITPR1	3.50e-04	98	32	3	CID000004507
Drug	AC1L1CR9	PLCG1 ITPR1	3.95e-04	21	32	2	CID000002023
Drug	loperamide	CACNA1A CACNA1E ITPR1	4.29e-04	105	32	3	CID000003954
Drug	AC1L1F6H	CACNA1A CACNA1E LPAR4	4.41e-04	106	32	3	CID000003104
Drug	Air Pollutants, Occupational	MFSD2A DDX60L IPO8 PSEN1 DDX60 PRDX1	4.56e-04	725	32	6	ctd:D000395
Drug	LY320135	CACNA1A CACNA1E	4.75e-04	23	32	2	CID005311257
Drug	tosylate	CCR8 PRDX2	4.75e-04	23	32	2	CID000006101
Drug	alpha-conotoxin SI	CACNA1A CACNA1E	4.75e-04	23	32	2	CID000163979
Drug	AC1L1UD1	CCR8 PRDX2	5.63e-04	25	32	2	CID000035754
Drug	lamotrigine	CACNA1A CACNA1E ITPR1	5.74e-04	116	32	3	CID000003878
Drug	Calcium	CACNA1A CACNA1E CCR8 PSEN1 ITPR1	5.79e-04	493	32	5	ctd:D002118
Drug	AC1NBU2S	CACNA1A CACNA1E ITPR1	5.88e-04	117	32	3	CID004473765
Drug	DPCPX	CACNA1A CACNA1E LPAR4	5.88e-04	117	32	3	CID000001329
Disease	familial hemiplegic migraine 1 (implicated_via_orthology)	CACNA1A CACNA1E	3.42e-06	3	32	2	DOID:0111181 (implicated_via_orthology)
Disease	migraine (implicated_via_orthology)	CACNA1A CACNA1E	6.83e-06	4	32	2	DOID:6364 (implicated_via_orthology)
Disease	hereditary ataxia (implicated_via_orthology)	CACNA1A CACNA1E	2.38e-05	7	32	2	DOID:0050951 (implicated_via_orthology)
Disease	Asbestosis	PRDX2 PRDX1	1.03e-04	14	32	2	C0003949
Disease	Pulmonary Fibrosis - from Asbestos Exposure	PRDX2 PRDX1	1.03e-04	14	32	2	C2930617
Disease	Dystonia	CACNA1A CACNA1E PSEN1	1.12e-04	86	32	3	C0013421
Disease	Ataxia, Spinocerebellar	CACNA1A ANO10	6.25e-04	34	32	2	C0087012
Disease	Spinocerebellar Ataxia Type 2	CACNA1A ANO10	6.25e-04	34	32	2	C0752121
Disease	Spinocerebellar Ataxia Type 1	CACNA1A ANO10	6.25e-04	34	32	2	C0752120
Disease	Spinocerebellar Ataxia Type 5	CACNA1A ANO10	6.25e-04	34	32	2	C0752123
Disease	Spinocerebellar Ataxia Type 7	CACNA1A ANO10	6.25e-04	34	32	2	C0752125
Disease	Spinocerebellar Ataxia Type 6 (disorder)	CACNA1A ANO10	6.25e-04	34	32	2	C0752124
Disease	Keloid	PRDX2 PRDX1	6.63e-04	35	32	2	C0022548
Disease	asthma (implicated_via_orthology)	ORMDL1 ITPR1	6.63e-04	35	32	2	DOID:2841 (implicated_via_orthology)
Disease	Spinocerebellar Ataxia Type 4	CACNA1A ANO10	6.63e-04	35	32	2	C0752122
Disease	oral squamous cell carcinoma (is_marker_for)	PLCG1 PRDX2	2.14e-03	63	32	2	DOID:0050866 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LRYFDYVFTGVFTFE	CACNA1A	1276	O00555
LRYFDYVFTGVFTFE	CACNA1E	1186	Q15878
FETTYFKKFPGYYVT	ACSS2	536	Q9NR19
KFVNAYSPIFYVAFF	ANO2	631	Q9NQ90
FTYDFSFYSADTKSP	KIF16B	56	Q96L93
ETIALYFGFLEYFTF	ANO10	206	Q9NW15
FVNFYSSPVYIAFFK	ANO7	596	Q6IWH7
YLFSIVGYLFFKDDF	ITPR1	2461	Q14643
EYDIFKYAPIFESDF	GARIN4	36	Q8IYT1
FDPFIYYFTLESFQK	LPAR4	306	Q99677
QFTIVFFKDAEYAYF	DDX60	81	Q8IY21
FFKDAEYAYFNFPEL	DDX60	86	Q8IY21
QFTIVFFKDAEYAYF	DDX60L	81	Q5H9U9
FFKDAEYAYFDFPEL	DDX60L	86	Q5H9U9
LSKFPAFDIYYVYSF	PLXNA1	236	Q9UIW2
NDLLISKVFYFFFYS	MFSD6	66	Q6ZSS7
FLASFYTKYDPTHFI	ORMDL1	111	Q9P0S3
KYVVLFFYPLDFTFV	PRDX2	36	P32119
GKYVVFFFYPLDFTF	PRDX1	36	Q06830
TEPIFFSFYVFFTKF	MFSD2A	436	Q8NA29
FSFYVFFTKFASGVS	MFSD2A	441	Q8NA29
YFFSTASEYPIFEKF	DNAJB7	136	Q7Z6W7
DLLFVFSFPFQTYYL	CCR8	81	P51685
PVFSKVFTVDYYFEE	CPNE7	71	Q9UBL6
YFEFSEFFLKTYAVG	IPO8	286	O15397
LDSPVYFFLSFFSFI	OR4C5	76	Q8NGB2
LSFFYFVKIANFSYP	TAS2R39	131	P59534
FVVFFSVFFPSFYED	SERF1A	91	O75920
FFSFIYLGEVFKTYN	PSEN1	176	P49768
TFVSGSEEYFKYFVL	SLC6A5	366	Q9Y345
KVPGFYQFFYSSDFE	URB1	1766	O60287
FSDTYVVPFVKYEFI	ZFHX4	3341	Q86UP3
EFLYTSEFFVYKYEI	ZBTB41	141	Q5SVQ8
PYFFLDEFVTFLFSK	PLCG1	291	P19174
QYFDISYIPSTVFFF	TXNL4B	71	Q9NX01
YTFPKFAVTYFQKSA	MYO7B	971	Q6PIF6