Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity	NANOGP1 NANOG	1.79e-05	4	35	2	GO:0001010
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	NANOGP1 RFX4 GLI2 NANOG NOTCH4 FOXC1	3.85e-04	560	35	6	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	NANOGP1 RFX4 GLI2 NANOG NOTCH4 FOXC1	4.07e-04	566	35	6	GO:0001216
GeneOntologyMolecularFunction	lysine-acetylated histone binding	NANOGP1 NANOG	1.26e-03	30	35	2	GO:0070577
GeneOntologyMolecularFunction	acetylation-dependent protein binding	NANOGP1 NANOG	1.34e-03	31	35	2	GO:0140033
GeneOntologyMolecularFunction	chromatin binding	NANOGP1 MBD5 CREBBP GLI2 NANOG FOXC1	1.63e-03	739	35	6	GO:0003682
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	NANOGP1 RFX4 MYRF GLI2 NR2F2 NANOG NOTCH4 FOXC1	2.58e-03	1412	35	8	GO:0000981
GeneOntologyMolecularFunction	transcription coregulator activity	TAF15 MAML2 CAMTA1 CREBBP SF1	2.80e-03	562	35	5	GO:0003712
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	TAF15 MAML2 CAMTA1 NANOGP1 CREBBP SF1 NANOG	3.52e-03	1160	35	7	GO:0030674
GeneOntologyBiologicalProcess	negative regulation of endodermal cell fate specification	NANOGP1 NANOG	1.77e-05	4	36	2	GO:0042664
GeneOntologyBiologicalProcess	lymph vessel development	HEG1 NR2F2 FOXC1	2.34e-05	32	36	3	GO:0001945
GeneOntologyBiologicalProcess	regulation of stem cell differentiation	NANOGP1 NANOG SLC4A11 FOXC1	2.61e-05	99	36	4	GO:2000736
GeneOntologyBiologicalProcess	regulation of endodermal cell fate specification	NANOGP1 NANOG	2.95e-05	5	36	2	GO:0042663
GeneOntologyBiologicalProcess	negative regulation of endodermal cell differentiation	NANOGP1 NANOG	4.42e-05	6	36	2	GO:1903225
GeneOntologyBiologicalProcess	positive regulation of transcription of Notch receptor target	MAML2 NOTCH4	6.19e-05	7	36	2	GO:0007221
GeneOntologyBiologicalProcess	negative regulation of cell fate specification	NANOGP1 NANOG	8.24e-05	8	36	2	GO:0009996
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	MAML2 CAMTA1 NANOGP1 RFX4 CREBBP GLI2 NR2F2 NANOG NOTCH4 FOXC1	9.42e-05	1390	36	10	GO:0045944
GeneOntologyBiologicalProcess	regulation of endodermal cell differentiation	NANOGP1 NANOG	1.32e-04	10	36	2	GO:1903224
GeneOntologyBiologicalProcess	endodermal cell fate specification	NANOGP1 NANOG	1.61e-04	11	36	2	GO:0001714
GeneOntologyBiologicalProcess	venous blood vessel morphogenesis	HEG1 NOTCH4	2.28e-04	13	36	2	GO:0048845
GeneOntologyBiologicalProcess	response to cocaine	ELAVL4 MYRF CREBBP	2.57e-04	71	36	3	GO:0042220
GeneOntologyBiologicalProcess	cell fate commitment	NANOGP1 GLI2 NR2F2 NANOG NOTCH4	2.85e-04	338	36	5	GO:0045165
GeneOntologyBiologicalProcess	cell dedifferentiation	NANOGP1 NANOG	3.07e-04	15	36	2	GO:0043697
GeneOntologyBiologicalProcess	dedifferentiation	NANOGP1 NANOG	3.07e-04	15	36	2	GO:0043696
GeneOntologyBiologicalProcess	endothelial cell morphogenesis	HEG1 NOTCH4	3.07e-04	15	36	2	GO:0001886
GeneOntologyBiologicalProcess	mesoderm formation	NANOGP1 NANOG FOXC1	3.93e-04	82	36	3	GO:0001707
GeneOntologyBiologicalProcess	regulation of protein processing	LDLRAD3 RFX4 NOTCH4	3.93e-04	82	36	3	GO:0070613
GeneOntologyBiologicalProcess	negative regulation of cell fate commitment	NANOGP1 NANOG	3.96e-04	17	36	2	GO:0010454
GeneOntologyBiologicalProcess	endodermal cell fate commitment	NANOGP1 NANOG	4.45e-04	18	36	2	GO:0001711
GeneOntologyBiologicalProcess	regulation of stem cell division	NANOGP1 NANOG	4.45e-04	18	36	2	GO:2000035
GeneOntologyBiologicalProcess	regulation of protein maturation	LDLRAD3 RFX4 NOTCH4	4.52e-04	86	36	3	GO:1903317
GeneOntologyBiologicalProcess	mesoderm morphogenesis	NANOGP1 NANOG FOXC1	4.52e-04	86	36	3	GO:0048332
GeneOntologyBiologicalProcess	spinal cord dorsal/ventral patterning	RFX4 GLI2	5.52e-04	20	36	2	GO:0021513
GeneOntologyBiologicalProcess	venous blood vessel development	HEG1 NOTCH4	5.52e-04	20	36	2	GO:0060841
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	RESF1 NANOGP1 CREBBP SF1 GLI2 NR2F2 NANOG NOTCH4 FOXC1	5.62e-04	1413	36	9	GO:1902679
GeneOntologyBiologicalProcess	spinal cord patterning	RFX4 GLI2	6.69e-04	22	36	2	GO:0021511
GeneOntologyBiologicalProcess	regulation of cell adhesion molecule production	CREBBP NOTCH4	7.32e-04	23	36	2	GO:0060353
GeneOntologyBiologicalProcess	mesodermal cell fate commitment	NANOGP1 NANOG	7.32e-04	23	36	2	GO:0001710
GeneOntologyBiologicalProcess	phosphatidylinositol-mediated signaling	PIK3CB PLCE1	7.98e-04	24	36	2	GO:0048015
GeneOntologyBiologicalProcess	regulation of smoothened signaling pathway	RFX4 CREBBP GLI2	8.10e-04	105	36	3	GO:0008589
GeneOntologyBiologicalProcess	cell adhesion molecule production	CREBBP NOTCH4	9.38e-04	26	36	2	GO:0060352
GeneOntologyBiologicalProcess	regulation of cell fate specification	NANOGP1 NANOG	1.17e-03	29	36	2	GO:0042659
GeneOntologyBiologicalProcess	cell fate specification	NANOGP1 GLI2 NANOG	1.28e-03	123	36	3	GO:0001708
GeneOntologyBiologicalProcess	formation of primary germ layer	NANOGP1 NANOG FOXC1	1.31e-03	124	36	3	GO:0001704
GeneOntologyBiologicalProcess	response to alkaloid	ELAVL4 MYRF CREBBP	1.34e-03	125	36	3	GO:0043279
GeneOntologyBiologicalProcess	protein processing	LDLRAD3 RFX4 MYRF NOTCH4	1.48e-03	285	36	4	GO:0016485
GeneOntologyBiologicalProcess	negative regulation of stem cell differentiation	NANOGP1 NANOG	1.51e-03	33	36	2	GO:2000737
GeneOntologyBiologicalProcess	response to retinoic acid	FZD10 NANOGP1 NANOG	1.53e-03	131	36	3	GO:0032526
GeneOntologyBiologicalProcess	mesodermal cell differentiation	NANOGP1 NANOG	1.70e-03	35	36	2	GO:0048333
GeneOntologyBiologicalProcess	tissue morphogenesis	HEG1 NANOGP1 GLI2 NANOG NOTCH4 FOXC1	1.74e-03	750	36	6	GO:0048729
GeneOntologyBiologicalProcess	cell fate commitment involved in formation of primary germ layer	NANOGP1 NANOG	1.90e-03	37	36	2	GO:0060795
GeneOntologyBiologicalProcess	stem cell differentiation	NANOGP1 NANOG SLC4A11 FOXC1	1.92e-03	306	36	4	GO:0048863
GeneOntologyBiologicalProcess	endodermal cell differentiation	NANOGP1 NANOG	2.00e-03	38	36	2	GO:0035987
GeneOntologyBiologicalProcess	negative regulation of transcription by RNA polymerase II	NANOGP1 CREBBP GLI2 NR2F2 NANOG NOTCH4 FOXC1	2.01e-03	1053	36	7	GO:0000122
HumanPheno	Short ear	CAMTA1 CREBBP	2.10e-05	3	14	2	HP:0400005
Domain	RNaseA_AS	RNASE6 RNASE8	9.49e-05	8	35	2	IPR023411
Domain	RNASE_PANCREATIC	RNASE6 RNASE8	9.49e-05	8	35	2	PS00127
Domain	RNAse_Pc	RNASE6 RNASE8	1.86e-04	11	35	2	SM00092
Domain	RNaseA	RNASE6 RNASE8	2.63e-04	13	35	2	PD000535
Domain	RnaseA	RNASE6 RNASE8	3.53e-04	15	35	2	PF00074
Domain	RNaseA	RNASE6 RNASE8	3.53e-04	15	35	2	IPR001427
Domain	RNaseA_domain	RNASE6 RNASE8	3.53e-04	15	35	2	IPR023412
Domain	-	RNASE6 RNASE8	3.53e-04	15	35	2	3.10.130.10
Domain	GPCR_2-like	ADGRL1 FZD10	5.64e-03	60	35	2	IPR017981
Domain	GPCR_2_secretin-like	ADGRL1 FZD10	5.64e-03	60	35	2	IPR000832
Domain	G_PROTEIN_RECEP_F2_4	ADGRL1 FZD10	5.83e-03	61	35	2	PS50261
Pathway	REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	MAML2 CREBBP NOTCH4	5.51e-06	20	25	3	M27881
Pathway	REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY	MAML2 CREBBP NOTCH4	1.57e-05	28	25	3	M6177
Pathway	WP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES	FZD10 PIK3CB GLI2 NOTCH4	5.15e-05	118	25	4	M39852
Pathway	REACTOME_GASTRULATION	MAML2 CREBBP NANOG FOXC1	7.29e-05	129	25	4	M46433
Pathway	KEGG_NOTCH_SIGNALING_PATHWAY	MAML2 CREBBP NOTCH4	7.59e-05	47	25	3	M7946
Pathway	WP_MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY	NANOGP1 CREBBP SF1 NR2F2 NANOG	1.61e-04	301	25	5	MM15983
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380	MAML2 NOTCH4	1.97e-04	12	25	2	M47532
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00381	MAML2 NOTCH4	1.97e-04	12	25	2	M47533
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382	MAML2 NOTCH4	2.33e-04	13	25	2	M47534
Pathway	REACTOME_RUNX3_REGULATES_NOTCH_SIGNALING	MAML2 CREBBP	2.71e-04	14	25	2	M27808
Pathway	REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_LATE_STAGE_BRANCHING_MORPHOGENESIS_PANCREATIC_BUD_PRECURSOR_CELLS	MAML2 CREBBP	3.57e-04	16	25	2	M27121
Pathway	REACTOME_SIGNALING_BY_NOTCH4	MAML2 CREBBP NOTCH4	3.98e-04	82	25	3	M594
Pathway	WP_HEDGEHOG_SIGNALING_PATHWAY	CREBBP GLI2	6.82e-04	22	25	2	MM15924
Pathway	WP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY	NANOGP1 CREBBP NANOG	7.32e-04	101	25	3	MM15829
Pathway	WP_WNT_SIGNALING_AND_PLURIPOTENCY	FZD10 CREBBP NANOG	7.32e-04	101	25	3	M39387
Pathway	REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY	MAML2 NOTCH4	7.47e-04	23	25	2	MM14954
Pathway	REACTOME_NOTCH3_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	MAML2 CREBBP	8.83e-04	25	25	2	M27880
Pathway	WP_CANONICAL_AND_NONCANONICAL_NOTCH_SIGNALING	MAML2 NOTCH4	1.03e-03	27	25	2	M39545
Pathway	REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING	MAML2 CREBBP NOTCH4	1.18e-03	119	25	3	M607
Pubmed	Deterministic and stochastic allele specific gene expression in single mouse blastomeres.	FZD10 NANOGP1 RFX4 PIK3CB GLI2 NR2F2 NANOG NOTCH4 FOXC1	3.85e-10	424	36	9	21731673
Pubmed	Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells.	NANOGP1 CREBBP NANOG	8.52e-08	9	36	3	16801560
Pubmed	Role of FOXC1 in regulating APSCs self-renewal via STI-1/PrPC signaling.	NANOGP1 NANOG FOXC1	1.67e-07	11	36	3	31588228
Pubmed	Identifying genes differentially expressed between PGCs and ES cells reveals a role for CREB-binding protein in germ cell survival.	NANOGP1 CREBBP NANOG	3.68e-07	14	36	3	17936260
Pubmed	Pluripotency factors regulate definitive endoderm specification through eomesodermin.	NANOGP1 NANOG FOXC1	5.65e-07	16	36	3	21245162
Pubmed	The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development.	NR2F2 NOTCH4 FOXC1	8.22e-07	18	36	3	16678147
Pubmed	Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 gene.	NANOGP1 CREBBP NANOG	9.76e-07	19	36	3	22982455
Pubmed	On the origin and evolutionary history of NANOG.	NANOGP1 NANOG	1.04e-06	2	36	2	24465486
Pubmed	NANOGP1, a tandem duplicate of NANOG, exhibits partial functional conservation in human naïve pluripotent stem cells.	NANOGP1 NANOG	1.04e-06	2	36	2	36621005
Pubmed	COUP-TFII Knock-down Promotes Proliferation and Invasion in Colorectal Cancer Cells via Activation of Akt Pathway and Up-regulation of FOXC1.	NR2F2 FOXC1	1.04e-06	2	36	2	31892566
Pubmed	FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer.	GLI2 FOXC1	1.04e-06	2	36	2	26565916
Pubmed	Transcriptional properties of human NANOG1 and NANOG2 in acute leukemic cells.	NANOGP1 NANOG	1.04e-06	2	36	2	20427424
Pubmed	A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome.	NANOGP1 SF1 NANOG	1.55e-06	22	36	3	19483677
Pubmed	Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.	NANOGP1 NANOG	3.12e-06	3	36	2	25825768
Pubmed	Epithelial cell senescence induces pulmonary fibrosis through Nanog-mediated fibroblast activation.	NANOGP1 NANOG	3.12e-06	3	36	2	31891567
Pubmed	Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.	NANOGP1 NANOG	3.12e-06	3	36	2	19447925
Pubmed	The pluripotency factor NANOG controls primitive hematopoiesis and directly regulates Tal1.	NANOGP1 NANOG	3.12e-06	3	36	2	30814124
Pubmed	Identification of two distinct transactivation domains in the pluripotency sustaining factor nanog.	NANOGP1 NANOG	3.12e-06	3	36	2	14728807
Pubmed	Isolation and characterization of the murine Nanog gene promoter.	NANOGP1 NANOG	3.12e-06	3	36	2	15916719
Pubmed	The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells.	NANOGP1 NANOG	3.12e-06	3	36	2	30846691
Pubmed	Generation of germline-competent induced pluripotent stem cells.	NANOGP1 NANOG	3.12e-06	3	36	2	17554338
Pubmed	Multiple phases in regulation of Nanog expression during pre-implantation development.	NANOGP1 NANOG	3.12e-06	3	36	2	26660234
Pubmed	Nanog retrotransposed genes with functionally conserved open reading frames.	NANOGP1 NANOG	3.12e-06	3	36	2	16845474
Pubmed	Nanog overcomes reprogramming barriers and induces pluripotency in minimal conditions.	NANOGP1 NANOG	3.12e-06	3	36	2	21194951
Pubmed	Identification and regulation of a stage-specific stem cell niche enriched by Nanog-positive spermatogonial stem cells in the mouse testis.	NANOGP1 NANOG	3.12e-06	3	36	2	22388986
Pubmed	NANOG changes in mouse kidneys with age.	NANOGP1 NANOG	3.12e-06	3	36	2	16313224
Pubmed	Crystal structure and DNA binding of the homeodomain of the stem cell transcription factor Nanog.	NANOGP1 NANOG	3.12e-06	3	36	2	18177668
Pubmed	Nanog promotes transfer of pluripotency after cell fusion.	NANOGP1 NANOG	3.12e-06	3	36	2	16791199
Pubmed	Expression of Nanog gene promotes NIH3T3 cell proliferation.	NANOGP1 NANOG	3.12e-06	3	36	2	16259959
Pubmed	Effect of Nanog overexpression on the metastatic potential of a mouse melanoma cell line B16-BL6.	NANOGP1 NANOG	3.12e-06	3	36	2	33665763
Pubmed	A novel NK-type homeobox gene, ENK (early embryo specific NK), preferentially expressed in embryonic stem cells.	NANOGP1 NANOG	3.12e-06	3	36	2	12609610
Pubmed	Heparan sulfate regulates self-renewal and pluripotency of embryonic stem cells.	NANOGP1 NANOG	3.12e-06	3	36	2	18024963
Pubmed	The pluripotency factor Nanog regulates pericentromeric heterochromatin organization in mouse embryonic stem cells.	NANOGP1 NANOG	3.12e-06	3	36	2	27125671
Pubmed	Cutting edge: Hypoxia-induced Nanog favors the intratumoral infiltration of regulatory T cells and macrophages via direct regulation of TGF-β1.	NANOGP1 NANOG	3.12e-06	3	36	2	24227785
Pubmed	Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain.	NANOGP1 NANOG	3.12e-06	3	36	2	22028025
Pubmed	Context-Dependent Functions of NANOG Phosphorylation in Pluripotency and Reprogramming.	NANOGP1 NANOG	3.12e-06	3	36	2	28457890
Pubmed	Requirement of Nanog dimerization for stem cell self-renewal and pluripotency.	NANOGP1 NANOG	3.12e-06	3	36	2	18436640
Pubmed	Stochastic promoter activation affects Nanog expression variability in mouse embryonic stem cells.	NANOGP1 NANOG	3.12e-06	3	36	2	25410303
Pubmed	Nanog co-regulated by Nodal/Smad2 and Oct4 is required for pluripotency in developing mouse epiblast.	NANOGP1 NANOG	3.12e-06	3	36	2	24929238
Pubmed	Nanog and transcriptional networks in embryonic stem cell pluripotency.	NANOGP1 NANOG	3.12e-06	3	36	2	17211451
Pubmed	The pluripotency factor nanog promotes breast cancer tumorigenesis and metastasis.	NANOGP1 NANOG	3.12e-06	3	36	2	23770853
Pubmed	The stem cell pluripotency factor NANOG activates transcription with two unusually potent subdomains at its C terminus.	NANOGP1 NANOG	3.12e-06	3	36	2	15502159
Pubmed	Genome editing demonstrates that the -5 kb Nanog enhancer regulates Nanog expression by modulating RNAPII initiation and/or recruitment.	NANOGP1 NANOG	3.12e-06	3	36	2	33334884
Pubmed	NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation.	NANOGP1 NANOG	3.12e-06	3	36	2	21499299
Pubmed	Nanog variability and pluripotency regulation of embryonic stem cells--insights from a mathematical model analysis.	NANOGP1 NANOG	3.12e-06	3	36	2	20574542
Pubmed	Gli affects the stemness and prognosis of epithelial ovarian cancer via homeobox protein NANOG.	GLI2 NANOG	3.12e-06	3	36	2	33313950
Pubmed	lincRNAs act in the circuitry controlling pluripotency and differentiation.	NANOGP1 NANOG	3.12e-06	3	36	2	21874018
Pubmed	Cell signalling regulates dynamics of Nanog distribution in embryonic stem cell populations.	NANOGP1 NANOG	3.12e-06	3	36	2	23054952
Pubmed	Phosphorylation of NANOG by casein kinase I regulates embryonic stem cell self-renewal.	NANOGP1 NANOG	3.12e-06	3	36	2	33107035
Pubmed	Nanog-independent reprogramming to iPSCs with canonical factors.	NANOGP1 NANOG	3.12e-06	3	36	2	24527385
Pubmed	Aromatic residues in the C-terminal domain 2 are required for Nanog to mediate LIF-independent self-renewal of mouse embryonic stem cells.	NANOGP1 NANOG	3.12e-06	3	36	2	18086680
Pubmed	Forced expression of Nanog in hematopoietic stem cells results in a gammadeltaT-cell disorder.	NANOGP1 NANOG	3.12e-06	3	36	2	17360937
Pubmed	H3K9 tri-methylation at Nanog times differentiation commitment and enables the acquisition of primitive endoderm fate.	NANOGP1 NANOG	3.12e-06	3	36	2	35976266
Pubmed	Nanog dynamics in single embryonic stem cells.	NANOGP1 NANOG	3.12e-06	3	36	2	26760119
Pubmed	Regulation of Nanog expression by phosphoinositide 3-kinase-dependent signaling in murine embryonic stem cells.	NANOGP1 NANOG	3.12e-06	3	36	2	17204467
Pubmed	CrxOS maintains the self-renewal capacity of murine embryonic stem cells.	NANOGP1 NANOG	3.12e-06	3	36	2	19800316
Pubmed	Nanog is dispensable for the generation of induced pluripotent stem cells.	NANOGP1 NANOG	3.12e-06	3	36	2	24461999
Pubmed	Chromatin decondensation and nuclear softening accompany Nanog downregulation in embryonic stem cells.	NANOGP1 NANOG	3.12e-06	3	36	2	23200040
Pubmed	Selenium Augments microRNA Directed Reprogramming of Fibroblasts to Cardiomyocytes via Nanog.	NANOGP1 NANOG	3.12e-06	3	36	2	26975336
Pubmed	Nanog suppresses cell migration by downregulating thymosin β4 and Rnd3.	NANOGP1 NANOG	3.12e-06	3	36	2	23329853
Pubmed	Locating and Characterizing a Transgene Integration Site by Nanopore Sequencing.	NANOGP1 NANOG	3.12e-06	3	36	2	30837263
Pubmed	NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers.	NANOGP1 NANOG	3.12e-06	3	36	2	26751055
Pubmed	Nanog induces hyperplasia without initiating tumors.	NANOGP1 NANOG	3.12e-06	3	36	2	25173648
Pubmed	Distinct Contributions of Tryptophan Residues within the Dimerization Domain to Nanog Function.	NANOGP1 NANOG	3.12e-06	3	36	2	27939294
Pubmed	Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells.	NANOGP1 NANOG	3.12e-06	3	36	2	17352742
Pubmed	OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells.	NANOGP1 NANOG	3.12e-06	3	36	2	23178592
Pubmed	Stochastic NANOG fluctuations allow mouse embryonic stem cells to explore pluripotency.	NANOGP1 NANOG	3.12e-06	3	36	2	25005472
Pubmed	Cell-permeant recombinant Nanog protein promotes pluripotency by inhibiting endodermal specification.	NANOGP1 NANOG	3.12e-06	3	36	2	24681518
Pubmed	Roles of the Nanog protein in murine F9 embryonal carcinoma cells and their endoderm-differentiated counterparts.	NANOGP1 NANOG	3.12e-06	3	36	2	16773043
Pubmed	Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming.	NANOGP1 NANOG	3.12e-06	3	36	2	23665121
Pubmed	Ectopic overexpression of Nanog induces tumorigenesis in non-tumorous fibroblasts.	NANOGP1 NANOG	3.12e-06	3	36	2	26733157
Pubmed	Transient Activation of Mitoflashes Modulates Nanog at the Early Phase of Somatic Cell Reprogramming.	NANOGP1 NANOG	3.12e-06	3	36	2	26549484
Pubmed	mNanog possesses dorsal mesoderm-inducing ability by modulating both BMP and Activin/nodal signaling in Xenopus ectodermal cells.	NANOGP1 NANOG	3.12e-06	3	36	2	23071603
Pubmed	Overexpression of NANOG in human ES cells enables feeder-free growth while inducing primitive ectoderm features.	NANOGP1 NANOG	3.12e-06	3	36	2	16501172
Pubmed	Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells.	NANOGP1 NANOG	3.12e-06	3	36	2	19582141
Pubmed	Identification of genes regulated by nanog which is involved in ES cells pluripotency and early differentiation.	NANOGP1 NANOG	3.12e-06	3	36	2	18442017
Pubmed	NANOG induction of fetal liver kinase-1 (FLK1) transcription regulates endothelial cell proliferation and angiogenesis.	NANOGP1 NANOG	3.12e-06	3	36	2	21119109
Pubmed	Pluripotency factor NANOG promotes germ cell maintenance in vitro without triggering dedifferentiation of spermatogonial stem cells.	NANOGP1 NANOG	3.12e-06	3	36	2	32145514
Pubmed	Nanog is the gateway to the pluripotent ground state.	NANOGP1 NANOG	3.12e-06	3	36	2	19703398
Pubmed	Nanog safeguards pluripotency and mediates germline development.	NANOGP1 NANOG	3.12e-06	3	36	2	18097409
Pubmed	Nanog Fluctuations in Embryonic Stem Cells Highlight the Problem of Measurement in Cell Biology.	NANOGP1 NANOG	3.12e-06	3	36	2	28636920
Pubmed	Heterogeneities in Nanog Expression Drive Stable Commitment to Pluripotency in the Mouse Blastocyst.	NANOGP1 NANOG	3.12e-06	3	36	2	25753417
Pubmed	A distinct expression pattern in mammalian testes indicates a conserved role for NANOG in spermatogenesis.	NANOGP1 NANOG	3.12e-06	3	36	2	20539761
Pubmed	Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes.	NANOGP1 NANOG	3.12e-06	3	36	2	18584034
Pubmed	Alternative splicing produces Nanog protein variants with different capacities for self-renewal and pluripotency in embryonic stem cells.	NANOGP1 NANOG	3.12e-06	3	36	2	21969378
Pubmed	The phosphoinositide-3-kinase/Akt pathway mediates the transient increase in Nanog expression during differentiation of F9 cells.	NANOGP1 NANOG	3.12e-06	3	36	2	20661723
Pubmed	NANOG restores the impaired myogenic differentiation potential of skeletal myoblasts after multiple population doublings.	NANOGP1 NANOG	3.12e-06	3	36	2	29245050
Pubmed	Cancer vaccination drives Nanog-dependent evolution of tumor cells toward an immune-resistant and stem-like phenotype.	NANOGP1 NANOG	3.12e-06	3	36	2	22337995
Pubmed	Mapping dynamic histone acetylation patterns to gene expression in nanog-depleted murine embryonic stem cells.	NANOGP1 NANOG	3.12e-06	3	36	2	21187909
Pubmed	Functional analysis of two Sp1/Sp3 binding sites in murine Nanog gene promoter.	NANOGP1 NANOG	3.12e-06	3	36	2	16541131
Pubmed	Role of Nanog in the maintenance of marrow stromal stem cells during post natal bone regeneration.	NANOGP1 NANOG	3.12e-06	3	36	2	22142851
Pubmed	The pluripotency rheostat Nanog functions as a dimer.	NANOGP1 NANOG	3.12e-06	3	36	2	18290762
Pubmed	NANOG amplifies STAT3 activation and they synergistically induce the naive pluripotent program.	NANOGP1 NANOG	3.12e-06	3	36	2	24462001
Pubmed	Reprogramming of mouse fibroblasts into induced pluripotent stem cells with Nanog.	NANOGP1 NANOG	3.12e-06	3	36	2	23333380
Pubmed	A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal.	NANOGP1 NANOG	3.12e-06	3	36	2	16790525
Pubmed	Primitive endoderm differentiates via a three-step mechanism involving Nanog and RTK signaling.	NANOGP1 NANOG	3.12e-06	3	36	2	22172669
Pubmed	Nanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity.	NANOGP1 NANOG	3.12e-06	3	36	2	23103910
Pubmed	Aggregation of embryonic stem cells induces Nanog repression and primitive endoderm differentiation.	NANOGP1 NANOG	3.12e-06	3	36	2	15494369
Pubmed	The histone acetyltransferase Myst2 regulates Nanog expression, and is involved in maintaining pluripotency and self-renewal of embryonic stem cells.	NANOGP1 NANOG	6.24e-06	4	36	2	25743411
Pubmed	CtBP-interacting BTB zinc finger protein (CIBZ) promotes proliferation and G1/S transition in embryonic stem cells via Nanog.	NANOGP1 NANOG	6.24e-06	4	36	2	22315219
Interaction	MAML2 interactions	MAML2 CREBBP NOTCH4	2.68e-06	17	33	3	int:MAML2
Cytoband	2q23.1	EPC2 MBD5	8.95e-06	6	36	2	2q23.1
Cytoband	2q14	GLI2 BUB1	3.27e-05	11	36	2	2q14
Cytoband	Ensembl 112 genes in cytogenetic band chr2q23	EPC2 MBD5	8.03e-04	53	36	2	chr2q23
Cytoband	Ensembl 112 genes in cytogenetic band chr20p13	LZTS3 SLC4A11	4.23e-03	123	36	2	chr20p13
GeneFamily	Ribonuclease A family	RNASE6 RNASE8	1.31e-04	13	24	2	723
GeneFamily	NKL subclass homeoboxes and pseudogenes	NANOGP1 NANOG	3.54e-03	67	24	2	519
CoexpressionAtlas	ratio_EmbryoidBody_vs_StemCell_top-relative-expression-ranked_500	FZD10 ELAVL4 RFX4 MYRF NR2F2 FOXC1 PLCE1	1.42e-05	498	35	7	PCBC_ratio_EB_vs_SC_500
CoexpressionAtlas	facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4	EPC2 ELAVL4 TAF15 HEG1 CAMTA1 MYRF PIK3CB TM4SF20 BUB1 PLCE1	5.01e-05	1370	35	10	facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4
ToppCell	Substantia_nigra-Macroglia-ASTROCYTE\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	FZD10 RFX4 GLI2 NANOG ENTPD2	7.61e-08	134	36	5	a632d78890fcc20db81d2cf6b299470706d2e182
ToppCell	Substantia_nigra-Macroglia-ASTROCYTE-Gja1\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	FZD10 RFX4 GLI2 NANOG ENTPD2	7.61e-08	134	36	5	8be2db71d9d29f9a57a64efdc89cf8c3e32b363b
ToppCell	Adult-Endothelial-endothelial_cell_of_vein-D231\|Adult / Lineage, Cell type, age group and donor	HEG1 NR2F2 NOTCH4 FOXC1	1.16e-05	174	36	4	2dd647c4fdf99fd1f7b838efef01baf2cbc3446d
ToppCell	CV-Mild-6\|Mild / Virus stimulation, Condition and Cluster	EPC2 ADGRL1 MBD5 CREBBP	1.18e-05	175	36	4	c4d530dbb37942427c9cd0a1533faeb6a3a45381
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRL1 FZD10 TM4SF20 ENTPD2	1.21e-05	176	36	4	ac3dc44755280e36c0947b6de3cd639dc17de8b6
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAML2 PIK3CB SLC4A11 FOXC1	1.24e-05	177	36	4	da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCell	COVID-19-kidney-Epi_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	GLI2 NR2F2 SLC4A11 PLCE1	1.29e-05	179	36	4	e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAML2 PIK3CB SLC4A11 FOXC1	1.41e-05	183	36	4	738e94b50c4c08c727d4eed0708dda08aa6891b4
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAML2 PIK3CB SLC4A11 FOXC1	1.41e-05	183	36	4	92fbd83a9d13ee91065cbd479fb298f1fd564568
ToppCell	COVID-19-Heart-Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	MAML2 LDLRAD3 NR2F2 PLCE1	1.44e-05	184	36	4	21790cdfa3b4036ad413fd44b94e31563116f25f
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HEG1 NOTCH4 FOXC1 ENTPD2	1.47e-05	185	36	4	a7ae76058b2082020cadec49d63b9f4e24d21734
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Astro-Astrocyte\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MAML2 RFX4 GLI2 ENTPD2	1.53e-05	187	36	4	5c73010fe4c85fb5cc1273f5504821229ca0cc4b
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Astro\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MAML2 RFX4 GLI2 ENTPD2	1.53e-05	187	36	4	5d3d68519c8e19f10c29f9d81712125be78ca15a
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MAML2 PIK3CB SLC4A11 FOXC1	1.60e-05	189	36	4	904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MAML2 RFX4 GLI2 ENTPD2	1.63e-05	190	36	4	78cc6c28b31de041c24175a98f47da256ecc15a2
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro-Astrocyte\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MAML2 RFX4 GLI2 ENTPD2	1.63e-05	190	36	4	e67d9400467b438592690b23d681e6c2fb8f09fd
ToppCell	COVID-19-kidney-vSMC/Pericyte\|kidney / Disease (COVID-19 only), tissue and cell type	LDLRAD3 GLI2 NR2F2 PLCE1	1.67e-05	191	36	4	fad8eaa536001b911d05ae2b12150c2398cc6f88
ToppCell	5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HEG1 LDLRAD3 NR2F2 FOXC1	1.70e-05	192	36	4	eafead22bba48ac5ee568faa8946c444445c1034
ToppCell	5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HEG1 LDLRAD3 NR2F2 FOXC1	1.88e-05	197	36	4	87eda06344498dc66cac292cf89746dc90b5cf67
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l34\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PAM FZD10 LDLRAD3 FOXC1	1.88e-05	197	36	4	6e111ba16fc8adde782b3f7da250248cddf11228
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PAM FZD10 LDLRAD3 FOXC1	1.88e-05	197	36	4	ece0c17eb68f394b20e588c0b0626d3987a4dbbb
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PAM FZD10 LDLRAD3 FOXC1	1.88e-05	197	36	4	4b6c0e028b9669c102df8e9dc63e284f8d5fd9ee
ToppCell	normal_Lung-Endothelial_cells-Stalk-like_ECs\|normal_Lung / Location, Cell class and cell subclass	HEG1 NR2F2 NOTCH4 FOXC1	1.92e-05	198	36	4	2a251d13c2488d15ca9b11e643c1d17d428b6ef0
ToppCell	facs-Trachea-nan-3m-Mesenchymal-chondrocyte\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAM FZD10 LDLRAD3 FOXC1	1.92e-05	198	36	4	71e847e8c24744d6df4a960348ad2ecf310373b4
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Bronchial_vessel\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	HEG1 NR2F2 NOTCH4 FOXC1	1.96e-05	199	36	4	53b6a661d381b1ed3ea96e61e8bd1750de7d9fda
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NR2F2 SLC4A11 FOXC1 PLCE1	1.96e-05	199	36	4	c972d3036151403f26fa9d6271520639c281ab84
ToppCell	Parenchyma_Control_(B.)-Endothelial-TX-Bronchial_vessel\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	HEG1 NR2F2 NOTCH4 FOXC1	1.96e-05	199	36	4	9c753043024871b1f1436fc39defac4da85e10cd
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NR2F2 SLC4A11 FOXC1 PLCE1	1.96e-05	199	36	4	b9338b739162cd8e5661c9a4dcb41a31219b5723
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Bronchial_vessel-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HEG1 NR2F2 NOTCH4 FOXC1	1.96e-05	199	36	4	d017dd91f9b10038f1f83753a766e534da2dbe89
ToppCell	5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HEG1 NR2F2 NOTCH4 FOXC1	2.00e-05	200	36	4	cd3c638961144a2fc91c437a173cc37c7452fa74
ToppCell	Hematolymphoid-Endothelial-NOSTRIN\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	PAM HEG1 LDLRAD3 NOTCH4	2.00e-05	200	36	4	032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCell	3'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HEG1 LDLRAD3 NR2F2 FOXC1	2.00e-05	200	36	4	cee07d9370656e1c428a7a9e9fbd175129901374
ToppCell	Hematolymphoid-Endothelial-NOSTRIN--\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	PAM HEG1 LDLRAD3 NOTCH4	2.00e-05	200	36	4	7fa54370221ed61bac0e09e6bcf1f3dff202a846
ToppCell	5'-Adult-SmallIntestine-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HEG1 NR2F2 NOTCH4 FOXC1	2.00e-05	200	36	4	2554b77edfe3d378296b0b25625caacbfb1c0e76
ToppCell	Hematolymphoid-Endothelial-NOSTRIN---\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	PAM HEG1 LDLRAD3 NOTCH4	2.00e-05	200	36	4	68fce28690246895fd33354b30960ebcc31aa4cc
ToppCell	Hematolymphoid-Endothelial-NOSTRIN-\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	PAM HEG1 LDLRAD3 NOTCH4	2.00e-05	200	36	4	376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCell	Hematolymphoid-Endothelial-NOSTRIN----L2-6\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	PAM HEG1 LDLRAD3 NOTCH4	2.00e-05	200	36	4	878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCell	Hematolymphoid-Endothelial\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	PAM HEG1 LDLRAD3 NOTCH4	2.00e-05	200	36	4	7136936d05ab344a560cf159684c881063b5430d
ToppCell	Frontal_cortex-Macroglia-ASTROCYTE-Gja1-Gfap-_astrocytes_(Gja1)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	RFX4 GLI2 ENTPD2	6.59e-05	97	36	3	031bc124739541b0b2591e1b6ef41f12adfd5c18
ToppCell	Frontal_cortex-Macroglia-ASTROCYTE-Gja1-Gfap-_astrocytes_(Gja1)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	RFX4 GLI2 ENTPD2	6.59e-05	97	36	3	0cd19f619f10a35d3107518aa83c0eda0572930a
ToppCell	Frontal_cortex-Macroglia-ASTROCYTE-Gja1-Gfap-_astrocytes_(Gja1)--\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	RFX4 GLI2 ENTPD2	6.59e-05	97	36	3	33330ac2de9e49d78b478f175068999235c9af25
ToppCell	Globus_pallidus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Gfap_(Gfap)--\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	GLI2 NANOG ENTPD2	8.34e-05	105	36	3	c41264e8b7d306d5d3ffa5b29eb36c7131d1cedf
ToppCell	Globus_pallidus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Gfap_(Gfap)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	GLI2 NANOG ENTPD2	8.34e-05	105	36	3	ed570cfdd452767dfb4dcae72282fe0fb25a4029
ToppCell	Globus_pallidus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Gfap_(Gfap)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	GLI2 NANOG ENTPD2	8.34e-05	105	36	3	ed3a431195c42c96c7d9c420e4b9fb00f415012d
ToppCell	Hippocampus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Nnat_(Nnat)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RFX4 GLI2 ENTPD2	1.27e-04	121	36	3	8334a6b2ced1d6a4808458d6d4232d1b688ba28a
ToppCell	Hippocampus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Nnat_(Nnat)--\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RFX4 GLI2 ENTPD2	1.27e-04	121	36	3	4b33eeed7b70da120133b14d42c104d2461d52dc
ToppCell	Hippocampus-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Nnat_(Nnat)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RFX4 GLI2 ENTPD2	1.27e-04	121	36	3	a33e4ae0b0efb702db1b646ac0486e3b6ce48457
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast-matrix_-_immature_4\|E18.5-samps / Age Group, Lineage, Cell class and subclass	TM4SF20 GLI2 BUB1	1.57e-04	130	36	3	169d88bffd7cd813a484d809defa638ceaca4bcb
ToppCell	pdx-Tumor_cells-T9\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	PAM UTP4 PLCE1	2.12e-04	144	36	3	0b94d978262a826c9254145aa98c6c30240243f9
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RFX4 SLC4A11 PLCE1	2.35e-04	149	36	3	24a7538b54b2a5291503c7493fefed4e45e8d710
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RFX4 SLC4A11 PLCE1	2.35e-04	149	36	3	cc6224c6b79f43b97adc1ce48ca4906bff2ad318
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|368C / Donor, Lineage, Cell class and subclass (all cells)	RESF1 MYRF BUB1	2.39e-04	150	36	3	c843bcf98c5fad2ca4339602f721f3fb782ae353
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HEG1 NANOG NOTCH4	2.39e-04	150	36	3	322aa0c3fc159a4b2897daac881dfc744b24ffc4
ToppCell	primary_visual_cortex-Non-neuronal-astrocyte\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RFX4 GLI2 ENTPD2	2.54e-04	153	36	3	95b28c5bd10ffb74c0993ebd565038b9818e4bd2
ToppCell	primary_visual_cortex-Non-neuronal-astrocyte-Astro\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RFX4 GLI2 ENTPD2	2.54e-04	153	36	3	b09f8def40a1ea56722f3398f61a036667b61cd9
ToppCell	primary_visual_cortex-Non-neuronal-astrocyte-Astro-Astro_Aqp4\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RFX4 GLI2 ENTPD2	2.54e-04	153	36	3	3ab9d55b3db51715c1d61eca142384195ce4b54f
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_ACHE\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NR2F2 NANOG PLCE1	2.58e-04	154	36	3	87de3be89e92d2e3980eaf973ee729ad871342aa
ToppCell	droplet-Heart-nan-24m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SARS2 GLI2 ENTPD2	2.84e-04	159	36	3	7ad3a91d29639b32f6264c91f401c14a35469ac0
ToppCell	5'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MAML2 SLC4A11 FOXC1	3.05e-04	163	36	3	f6847f47a8856c0d4136c1af317432d45eccfde9
ToppCell	5'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell-SMG_duct\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MAML2 SLC4A11 FOXC1	3.05e-04	163	36	3	a1fbefe53523a9879a4d4b493071059798b5f917
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c02-NCAM1\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PAM HEG1 FOXC1	3.05e-04	163	36	3	1c014e373667be290d7fb5d24c06c6f313ac8fa3
ToppCell	5'-Airway_Nasal_SMG\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MAML2 SLC4A11 FOXC1	3.05e-04	163	36	3	d8450bf9c6d2ec5dd1472952c9e65f82f995337a
ToppCell	5'-Airway_Nasal_SMG-Epithelial\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MAML2 SLC4A11 FOXC1	3.05e-04	163	36	3	454a5e87e2f9f66e38cc5aa1b433c47b54c9be42
ToppCell	5'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell-SMG_duct-SMG_duct_L.0.6.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MAML2 SLC4A11 FOXC1	3.05e-04	163	36	3	be6cc44df9a2b10dce1a353717c279c3558f8fec
ToppCell	5'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MAML2 SLC4A11 FOXC1	3.05e-04	163	36	3	d9bd9d90cfa4e85d5ea51f8f3ee14a700571f508
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEG1 MAML2 NR2F2	3.11e-04	164	36	3	ed7e0c8ccad7d19b9cc72d70391936ff5e698f28
ToppCell	PND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FZD10 NR2F2 PLCE1	3.16e-04	165	36	3	347b59aa625a8a960828b8620824d8ac48990e07
ToppCell	PND03-Endothelial-Endothelial_lymphatic\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FZD10 NR2F2 PLCE1	3.16e-04	165	36	3	1890f9c33b0c5b381d57f97042da2610a093a6de
ToppCell	PND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FZD10 NR2F2 PLCE1	3.16e-04	165	36	3	507c89ece0a336b8e9c65b79889a714e17ddca27
ToppCell	PND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FZD10 NR2F2 PLCE1	3.16e-04	165	36	3	39a25be081a5d59c7cf107a997d352793d5025fb
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|356C / Donor, Lineage, Cell class and subclass (all cells)	MAML2 RESF1 NOTCH4	3.22e-04	166	36	3	c4f7ea1cad962b1d6ad77423d15978b68a0d6f1d
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LDLRAD3 GLI2 PLCE1	3.28e-04	167	36	3	7cb1b11e8e24a10115e46ffbb74889e672a7a026
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEG1 MAML2 NR2F2	3.28e-04	167	36	3	fa5184441446fde6c7eaaf91aad038cf045dde65
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LDLRAD3 GLI2 PLCE1	3.28e-04	167	36	3	bb53a478b5d821d6d82c15bc4ed075b67682457c
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LDLRAD3 GLI2 PLCE1	3.28e-04	167	36	3	e228b8373ffd4436e6b944e26d0fadf3ac289b21
ToppCell	droplet-Heart-nan-18m-Hematologic-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RNASE6 SARS2 MBD5	3.34e-04	168	36	3	2201ae834b53cbdc085f8f02607fa5b5bd911268
ToppCell	COVID-19-kidney-PEC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MYRF SLC4A11 PLCE1	3.34e-04	168	36	3	a086c306be430adf0632ba53e98cd8014d2de330
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-OPC_related-Oligodendrocyte/OPC\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	MAML2 LDLRAD3 PLCE1	3.39e-04	169	36	3	b1611e61f635f8f9b87250e026ad30999cbee041
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HEG1 NR2F2 FOXC1	3.39e-04	169	36	3	58136b8a0bf2dab45c91a053ef7225ea49ccb871
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-OPC_related\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	MAML2 LDLRAD3 PLCE1	3.39e-04	169	36	3	29db25e7c5f31d98a08a35d7ec5ade203242bc50
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HEG1 NR2F2 FOXC1	3.39e-04	169	36	3	04c6ed38e1d1befba5ef5f37a3c1e045a0b163d6
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	HEG1 MAML2 NANOG	3.39e-04	169	36	3	6614c9851537e4c21b1e45ff0cc3bad07ef9d034
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	HEG1 MAML2 NANOG	3.39e-04	169	36	3	665b958f4a720ca369a8a0abc7fbe8b6e13c8ce5
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	C20orf173 HEG1 LZTS3	3.39e-04	169	36	3	f086b50791e1c93e253eb5e8d6c4bf617b1416c3
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NR2F2 ENTPD2 PLCE1	3.45e-04	170	36	3	1f994b690e881106a5d54b3080ccce6260bc3ac5
ToppCell	COVID-19-kidney-PEC\|kidney / Disease (COVID-19 only), tissue and cell type	MYRF SLC4A11 PLCE1	3.57e-04	172	36	3	36a96714a0eb6ac438648135336c9791881ddadb
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	MAML2 RESF1 NOTCH4	3.57e-04	172	36	3	a9e13aa36087170dadca421ba9de588e5a1cf715
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HEG1 NR2F2 FOXC1	3.57e-04	172	36	3	fc092a0631555d79e00ef9890cbd806e15bca2d4
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HEG1 NR2F2 FOXC1	3.57e-04	172	36	3	745725bd10c82017d678463b8fef0d2dcf09a8fd
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RNASE6 PIK3CB PLCE1	3.57e-04	172	36	3	a5344760b10ecdc0101f78b93b8fc0f8107068c5
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid-cDC1\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RNASE6 LDLRAD3 PIK3CB	3.63e-04	173	36	3	d13ae4046a25ee0fb492ddedf44583a879a432e9
ToppCell	AT1_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	PAM HEG1 MYRF	3.63e-04	173	36	3	3afca2a429c634af0220c1aa19ce4cf4ee3e8b3e
ToppCell	3'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HEG1 NR2F2 FOXC1	3.63e-04	173	36	3	b57d14e2c2368304cb903562d06ce8228f53857c
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	HEG1 MAML2 NOTCH4	3.76e-04	175	36	3	f3a68aeb79c4935006e17a5ff3445a8ec0e33f5f
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_GRIP2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEG1 MAML2 NR2F2	3.76e-04	175	36	3	0c648e7f67ffbe3b476a2ca77d246554f8cd1882
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYRF PIK3CB FOXC1	3.82e-04	176	36	3	33323c97afe509147956b8df9f92ca6b0537e604
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NR2F2 SLC4A11 FOXC1	3.82e-04	176	36	3	90f36f10c6ed440a0ca549f23219398853f1fbc3
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAM HEG1 NR2F2	3.82e-04	176	36	3	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	Adult-Endothelial-endothelial_cell_of_vein\|Adult / Lineage, Cell type, age group and donor	HEG1 NOTCH4 FOXC1	3.82e-04	176	36	3	043683c61c5d1a7f8a4666a612310246bd3d83a2
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LDLRAD3 GLI2 PLCE1	3.88e-04	177	36	3	4943d040eee0f9dceaddc7498171281d170e271f
Drug	Flumethasone [2135-17-3]; Down 200; 9.8uM; PC3; HT_HG-U133A	SECISBP2L TAF15 PIK3CB CREBBP SF1	1.13e-05	194	35	5	4272_DN
Drug	DO 897/99; Up 200; 8.2uM; HL60; HG-U133A	ELAVL4 HEG1 RNASE6 LZTS3 NR2F2	1.18e-05	196	35	5	1728_UP
Drug	Drofenine hydrochloride [548-66-3]; Down 200; 11.4uM; PC3; HT_HG-U133A	SECISBP2L PAM ADGRL1 LZTS3 NR2F2	1.30e-05	200	35	5	7129_DN
Drug	SBFI	SARS2 CREBBP ENTPD2	1.31e-05	30	35	3	CID000123881
Disease	colon cancer (implicated_via_orthology)	NANOGP1 NANOG	7.04e-05	11	34	2	DOID:219 (implicated_via_orthology)
Disease	Renal glomerular disease	CREBBP PLCE1	3.21e-04	23	34	2	C0268731
Disease	Glomerulopathy Assessment	CREBBP PLCE1	3.21e-04	23	34	2	C4521256
Disease	Parkinson disease	PAM RESF1 LZTS3 RFX4	4.93e-04	321	34	4	MONDO_0005180
Disease	worry measurement	PAM CAMTA1 NOTCH4	7.41e-04	154	34	3	EFO_0009589
Disease	endometrial cancer (is_marker_for)	PIK3CB NOTCH4	7.49e-04	35	34	2	DOID:1380 (is_marker_for)
Disease	clinical treatment	PAM NOTCH4	1.03e-03	41	34	2	EFO_0007056
Disease	cortical thickness	PAM CAMTA1 RFX4 NR2F2 UTP4 PLCE1	1.54e-03	1113	34	6	EFO_0004840
Disease	IGFBP-3 measurement	CREBBP NOTCH4	1.78e-03	54	34	2	EFO_0004626
Disease	Diffuse Large B-Cell Lymphoma	PIK3CB CREBBP	1.84e-03	55	34	2	C0079744
Disease	Malignant neoplasm of skin	GLI2 NOTCH4	2.12e-03	59	34	2	C0007114
Disease	Skin Neoplasms	GLI2 NOTCH4	2.12e-03	59	34	2	C0037286

Protein segments in the cluster

Peptide	Gene	Start	Entry
SPQTLPMNNSCLTNA	EPC2	716	Q52LR7
MNFDPDCFLNNPKQG	CAMTA1	481	Q9Y6Y1
SNPGNNMACISKNQG	BUB1	176	O43683
ACGMDTLPLNGNFNN	ADGRL1	1236	O94910
PATSQTGPGICMNAN	CREBBP	166	Q92793
MQPGSDQNHFCQPTD	PAM	621	P19021
SNGPSSNNRNCPSPM	ELAVL4	26	P26378
SNNRNCPSPMQTGAT	ELAVL4	31	P26378
PNPSCGNMNFARRNS	TAF15	361	Q92804
AAGSPAENSQQLPCM	RFX4	561	Q33E94
YPTSRFGSQCMQPNN	NR2F2	191	P24468
TNECNIPGNFMCSNG	LDLRAD3	26	Q86YD5
NFHSMQNLCPPQTNG	LZTS3	171	O60299
QSPCTMAQRPQNFNS	ENTPD2	281	Q9Y5L3
LFNAMGISPNACFAQ	OR51A7	86	Q8NH64
ESLQSCMQFQPNSPA	NANOG	246	Q9H9S0
GALNQFPQSCSNMPA	GLI2	1261	P10070
SNPCPSTAMCNNTQG	HEG1	1031	Q9ULI3
PCSNPNTGSGYMNSQ	MAML2	731	Q8IZL2
NMGMYGNLPCNQPNT	MAML2	866	Q8IZL2
NDPNYLCMEAPNNGS	FZD10	141	Q9ULW2
SPVNGNSSCQMAFPS	FOXC1	521	Q12948
IPCPANNNPMACLFQ	MBD5	1001	Q9P267
SPQSPSCCFQGMNSG	C20orf173	41	Q96LM9
GCGMTPNANPSQIYN	SARS2	271	Q9NP81
NFPVTAMAIAPNTNN	UTP4	526	Q969X6
LQPCENSPTMSQNGY	SLC4A11	11	Q8NBS3
VSGQNVCPSNSMGSP	PLCE1	1876	Q9P212
NQEACMYPGNSNPIS	RESF1	46	Q9HCM1
ASQNSPYCMTPVSQG	SECISBP2L	636	Q93073
PSPLQCNRAMSGINN	RNASE6	41	Q93091
CQDVFSFQVSPNMNP	PIK3CB	206	P42338
SRPCQNGATCMAQPS	NOTCH4	936	Q99466
KGPLMCNSPSNSNAN	TM4SF20	111	Q53R12
QHVQPSPQACNSAMS	RNASE8	41	Q8TDE3
QSCMQFQPNSPASDL	NANOGP1	176	Q8N7R0
QQQAAAAASPGAPQM	SF1	546	Q15637
CNNNNGMGAAPKPFP	MYRF	101	Q9Y2G1