Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	chromatin insulator sequence binding	ZNF692 REPIN1 ZNF276	2.54e-05	7	182	3	GO:0043035
GeneOntologyCellularComponent	leading edge membrane	ERBB2 ANK1 VEZT HIP1R PLXND1 CHRNA7 SYNE2 ARHGEF4 CHRFAM7A	9.29e-05	210	181	9	GO:0031256
GeneOntologyCellularComponent	cell projection membrane	ERBB2 SLC11A2 ANK1 VEZT HIP1R PLXND1 GPR88 CHRNA7 ACE2 SYNE2 ARHGEF4 CHRFAM7A SLC26A6	1.03e-04	431	181	13	GO:0031253
GeneOntologyCellularComponent	receptor complex	ERBB2 FLT4 PLXND1 TSPAN32 ACVRL1 ITGB5 CHRNA7 LIFR CD14 CPT1C TRBV4-1 CHRFAM7A NOTCH1 PLXNB3 IFNL2	1.69e-04	581	181	15	GO:0043235
GeneOntologyCellularComponent	semaphorin receptor complex	ERBB2 PLXND1 PLXNB3	1.71e-04	13	181	3	GO:0002116
GeneOntologyCellularComponent	spine apparatus membrane	CHRNA7 CHRFAM7A	2.22e-04	3	181	2	GO:0098897
GeneOntologyCellularComponent	cell leading edge	NRBP1 ERBB2 ANK1 VEZT CARMIL3 HIP1R PLXND1 ITGB5 CHRNA7 SYNE2 NHS ARHGEF4 CHRFAM7A	4.33e-04	500	181	13	GO:0031252
GeneOntologyCellularComponent	sarcoplasmic reticulum membrane	CAMK2D RYR2 RYR3 SYNE2	6.14e-04	45	181	4	GO:0033017
GeneOntologyCellularComponent	axolemma	ANK1 CHRNA7 CHRFAM7A	7.57e-04	21	181	3	GO:0030673
GeneOntologyCellularComponent	sarcoplasmic reticulum	ANK1 CAMK2D RYR2 RYR3 SYNE2	1.01e-03	88	181	5	GO:0016529
GeneOntologyCellularComponent	apical plasma membrane	PAPPA2 ERBB2 SLC11A2 HIP1R SLC39A4 CHRNA7 ACE2 NHS CHRFAM7A SLC26A6 NOTCH1 GP2	1.14e-03	487	181	12	GO:0016324
Domain	Ank_2	ANKRD13B ANKK1 ANKFY1 ANK1 ANKRD39 ESPNL ANKRD26 NFKBIZ ASB12 ANKRD44 TONSL PPP1R16B EHMT1 ANKRD18A TNKS TNKS2 ANKRD52 NOTCH1 ANKRD7	3.76e-13	215	183	19	PF12796
Domain	Ank	ANKRD13B ANKK1 ANKFY1 ANK1 ANKRD39 ESPNL ANKRD26 NFKBIZ ASB12 ANKRD44 TONSL PPP1R16B EHMT1 ANKRD18A TNKS TNKS2 ANKRD52 NOTCH1 ANKRD7	1.08e-12	228	183	19	PF00023
Domain	-	ANKRD13B ANKK1 ANKFY1 ANK1 ANKRD39 ESPNL ANKRD26 NFKBIZ ASB12 ANKRD44 TONSL PPP1R16B EHMT1 ANKRD18A TNKS TNKS2 ANKRD52 NOTCH1 ANKRD7	4.80e-12	248	183	19	1.25.40.20
Domain	ANK	ANKRD13B ANKK1 ANKFY1 ANK1 ANKRD39 ESPNL ANKRD26 NFKBIZ ASB12 ANKRD44 TONSL PPP1R16B EHMT1 ANKRD18A TNKS TNKS2 ANKRD52 NOTCH1 ANKRD7	5.93e-12	251	183	19	SM00248
Domain	ANK_REPEAT	ANKRD13B ANKK1 ANKFY1 ANK1 ANKRD39 ESPNL ANKRD26 NFKBIZ ASB12 ANKRD44 TONSL PPP1R16B EHMT1 ANKRD18A TNKS TNKS2 ANKRD52 NOTCH1 ANKRD7	6.82e-12	253	183	19	PS50088
Domain	Ankyrin_rpt-contain_dom	ANKRD13B ANKK1 ANKFY1 ANK1 ANKRD39 ESPNL ANKRD26 NFKBIZ ASB12 ANKRD44 TONSL PPP1R16B EHMT1 ANKRD18A TNKS TNKS2 ANKRD52 NOTCH1 ANKRD7	7.31e-12	254	183	19	IPR020683
Domain	ANK_REP_REGION	ANKRD13B ANKK1 ANKFY1 ANK1 ANKRD39 ESPNL ANKRD26 NFKBIZ ASB12 ANKRD44 TONSL PPP1R16B EHMT1 ANKRD18A TNKS TNKS2 ANKRD52 NOTCH1 ANKRD7	7.31e-12	254	183	19	PS50297
Domain	Ankyrin_rpt	ANKRD13B ANKK1 ANKFY1 ANK1 ANKRD39 ESPNL ANKRD26 NFKBIZ ASB12 ANKRD44 TONSL PPP1R16B EHMT1 ANKRD18A TNKS TNKS2 ANKRD52 NOTCH1 ANKRD7	1.26e-11	262	183	19	IPR002110
Domain	DUF89	ARMT1 PANK4	9.55e-05	2	183	2	IPR002791
Domain	DUF89	ARMT1 PANK4	9.55e-05	2	183	2	PF01937
Domain	HIP1_clath_bdg	HIP1 HIP1R	9.55e-05	2	183	2	PF16515
Domain	NPY4_rcpt	NPY4R2 NPY4R	9.55e-05	2	183	2	IPR001933
Domain	HIP1_clath-bd	HIP1 HIP1R	9.55e-05	2	183	2	IPR032422
Domain	Sla2_fam	HIP1 HIP1R	9.55e-05	2	183	2	IPR030224
Domain	-	VPS11 DMXL2 COPA PLXND1 DCAF12L2 BIRC6 TBL3 SEMA6D DCAF10 PRPF4 WDR6 PLXNB3	1.13e-04	333	183	12	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	VPS11 DMXL2 COPA PLXND1 DCAF12L2 BIRC6 TBL3 SEMA6D DCAF10 PRPF4 WDR6 PLXNB3	1.20e-04	335	183	12	IPR015943
Domain	DUF3496	ANKRD26 ANKRD18A	2.85e-04	3	183	2	IPR021885
Domain	Ryanodine_rcpt	RYR2 RYR3	2.85e-04	3	183	2	IPR003032
Domain	Ryanrecept_TM4-6	RYR2 RYR3	2.85e-04	3	183	2	IPR009460
Domain	RyR	RYR2 RYR3	2.85e-04	3	183	2	PF02026
Domain	DUF3496	ANKRD26 ANKRD18A	2.85e-04	3	183	2	PF12001
Domain	RR_TM4-6	RYR2 RYR3	2.85e-04	3	183	2	PF06459
Domain	Ryan_recept	RYR2 RYR3	2.85e-04	3	183	2	IPR013333
Domain	ILWEQ_dom	HIP1 HIP1R	5.66e-04	4	183	2	IPR002558
Domain	ILWEQ	HIP1 HIP1R	5.66e-04	4	183	2	SM00307
Domain	ANTH_dom	HIP1 HIP1R	5.66e-04	4	183	2	IPR011417
Domain	ILWEQ	HIP1 HIP1R	5.66e-04	4	183	2	PD011820
Domain	ANTH	HIP1 HIP1R	5.66e-04	4	183	2	PF07651
Domain	-	HIP1 HIP1R	5.66e-04	4	183	2	1.20.1410.10
Domain	I_LWEQ	HIP1 HIP1R	5.66e-04	4	183	2	PF01608
Domain	I_LWEQ	HIP1 HIP1R	5.66e-04	4	183	2	PS50945
Domain	PSI	PLXND1 ITGB5 SEMA6D PLXNB3	8.92e-04	44	183	4	IPR016201
Domain	PSI	PLXND1 ITGB5 SEMA6D PLXNB3	1.06e-03	46	183	4	SM00423
Domain	RIH_assoc-dom	RYR2 RYR3	1.40e-03	6	183	2	IPR013662
Domain	Ins145_P3_rec	RYR2 RYR3	1.40e-03	6	183	2	PF08709
Domain	RIH_assoc	RYR2 RYR3	1.40e-03	6	183	2	PF08454
Domain	RIH_dom	RYR2 RYR3	1.40e-03	6	183	2	IPR000699
Domain	Ins145_P3_rcpt	RYR2 RYR3	1.40e-03	6	183	2	IPR014821
Domain	Ryanodine_recept-rel	RYR2 RYR3	1.40e-03	6	183	2	IPR015925
Domain	-	RYR2 RYR3	1.40e-03	6	183	2	1.25.10.30
Domain	RYDR_ITPR	RYR2 RYR3	1.40e-03	6	183	2	PF01365
Domain	Leu-rich_rpt	TCTE1 CARMIL3 PIDD1 CPN2 FBXL19 LRFN4 CD14 SLIT3 TONSL	1.45e-03	271	183	9	IPR001611
Domain	L_dom-like	TCTE1 ERBB2 CARMIL3 PIDD1 CPN2 FBXL19 LRFN4 CD14 SLIT3 TONSL	1.51e-03	328	183	10	IPR032675
Domain	Notch_dom	PAPPA2 NOTCH1	1.94e-03	7	183	2	IPR000800
Domain	Notch	PAPPA2 NOTCH1	1.94e-03	7	183	2	PF00066
Domain	NL	PAPPA2 NOTCH1	1.94e-03	7	183	2	SM00004
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DAB2IP ERBB2 HIP1 HIP1R PEX6 PLXND1 FBXL19 NPHP4 BIRC6 REPIN1 AHDC1 ITGB5 ACOX3 BMP4 ZNF276 PSME4 MROH6 SND1 UCKL1 INTS11 EHMT1 CPSF1 ZFYVE26 ULK1 ARHGEF4 SLC52A2 NOTCH1 ABCC10	1.05e-11	1105	187	28	35748872
Pubmed	Bone Marrow-Derived Cells Restore Functional Integrity of the Gut Epithelial and Vascular Barriers in a Model of Diabetes and ACE2 Deficiency.	INS ACE2 INS-IGF2	1.53e-07	3	187	3	31610731
Pubmed	Excessive ROS production and enhanced autophagy contribute to myocardial injury induced by branched-chain amino acids: Roles for the AMPK-ULK1 signaling pathway and α7nAChR.	CHRNA7 ULK1 CHRFAM7A	1.53e-07	3	187	3	32980459
Pubmed	Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury.	INS ACE2 INS-IGF2	1.53e-07	3	187	3	17600118
Pubmed	The impact of Ca²⁺/calmodulin-dependent protein kinase II on insulin gene expression in MIN6 cells.	INS CAMK2D INS-IGF2	1.53e-07	3	187	3	22554507
Pubmed	Loss of Angiotensin-Converting Enzyme 2 Exacerbates Diabetic Retinopathy by Promoting Bone Marrow Dysfunction.	INS ACE2 INS-IGF2	1.53e-07	3	187	3	29761600
Pubmed	Human recombinant ACE2 reduces the progression of diabetic nephropathy.	INS ACE2 INS-IGF2	6.09e-07	4	187	3	19934006
Pubmed	Bone morphogenetic protein-7 (BMP-7) augments insulin sensitivity in mice with type II diabetes mellitus by potentiating PI3K/AKT pathway.	INS BMP4 INS-IGF2	6.09e-07	4	187	3	28186649
Pubmed	RILP Restricts Insulin Secretion Through Mediating Lysosomal Degradation of Proinsulin.	INS RILP INS-IGF2	6.09e-07	4	187	3	31624142
Pubmed	Hyperglycemia cooperates with Tet2 heterozygosity to induce leukemia driven by proinflammatory cytokine-induced lncRNA Morrbid.	TET2 INS INS-IGF2	6.09e-07	4	187	3	33090974
Pubmed	Loss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: a critical role of the angiotensin II/AT1 receptor axis.	INS ACE2 INS-IGF2	1.52e-06	5	187	3	22474255
Pubmed	Rac1 Activation Caused by Membrane Translocation of a Guanine Nucleotide Exchange Factor in Akt2-Mediated Insulin Signaling in Mouse Skeletal Muscle.	INS SERGEF INS-IGF2	1.52e-06	5	187	3	27163697
Pubmed	Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7.	INS TSPAN32 INS-IGF2	1.52e-06	5	187	3	10950922
Pubmed	Nrf2 Deficiency Upregulates Intrarenal Angiotensin-Converting Enzyme-2 and Angiotensin 1-7 Receptor Expression and Attenuates Hypertension and Nephropathy in Diabetic Mice.	INS ACE2 INS-IGF2	1.52e-06	5	187	3	29211853
Pubmed	The ACE2/Ang-(1-7)/Mas Axis Regulates the Development of Pancreatic Endocrine Cells in Mouse Embryos.	INS ACE2 INS-IGF2	1.52e-06	5	187	3	26029927
Pubmed	The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse.	INS CHRNA7 CHRFAM7A INS-IGF2	2.33e-06	18	187	4	32708537
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ANKFY1 POLR1A COPA CAMK2D HIP1R CHD1L BIRC6 TBL3 PHGDH NMD3 POLR1F CRNKL1 NOP14 PSME4 SND1 WDR6 INTS11 XRN1 CPSF1 ASCC3 ANKRD52 GOT2	4.15e-06	1353	187	22	29467282
Pubmed	Islet architecture: A comparative study.	INS SLIT3 INS-IGF2	5.27e-06	7	187	3	20606719
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	DAB2IP CAND2 INS CAMK2D HIP1R NPHP4 SLC35A4 FBXO44 INS-IGF2 ABCC10 SERPINA7	5.99e-06	371	187	11	15747579
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	EEFSEC HIP1 POLR1A FLYWCH1 TRPS1 HIP1R ZNF217 REPIN1 AHDC1 TFAP2C TBL3 PHGDH POLR1F CRNKL1 NOP14 INTS2 SND1 INTS11 PTRH1 XRN1 EHMT1 ZFHX3 ASCC3	6.26e-06	1497	187	23	31527615
Pubmed	Distinct expression patterns of splicing isoforms of mNumb in the endocrine lineage of developing pancreas.	INS INS-IGF2 NOTCH1	1.25e-05	9	187	3	14641329
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	ZSWIM8 POLR1A COPA BIRC6 TBL3 CRNKL1 NOP14 SND1 WDR6 SYNE2 XRN1 CPSF1 ASCC3 ANKRD52	1.34e-05	653	187	14	22586326
Pubmed	Beta-catenin (CTNNB1) induces Bmp expression in urogenital sinus epithelium and participates in prostatic bud initiation and patterning.	CHRNA7 BMP4 CHRFAM7A	2.45e-05	11	187	3	23396188
Pubmed	Neuritic dystrophy and neuronopathy in Akita (Ins2(Akita)) diabetic mouse sympathetic ganglia.	INS INS-IGF2	2.88e-05	2	187	2	19111542
Pubmed	Progressive Thinning of Retinal Nerve Fiber Layer/Ganglion Cell Layer (RNFL/GCL) as Biomarker and Pharmacological Target of Diabetic Retinopathy.	INS INS-IGF2	2.88e-05	2	187	2	37628852
Pubmed	Decreased Satellite Cell Number and Function in Humans and Mice With Type 1 Diabetes Is the Result of Altered Notch Signaling.	INS INS-IGF2	2.88e-05	2	187	2	27335233
Pubmed	Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	34453977
Pubmed	Bioinformatics Analysis of Weighted Genes in Diabetic Retinopathy.	INS INS-IGF2	2.88e-05	2	187	2	30480744
Pubmed	The implications of hyperoxia, type 1 diabetes and sex on cardiovascular physiology in mice.	INS INS-IGF2	2.88e-05	2	187	2	34845324
Pubmed	Thymic expression of mutated B16:A preproinsulin messenger RNA does not reverse acceleration of NOD diabetes associated with insulin 2 (thymic expressed insulin) knockout.	INS INS-IGF2	2.88e-05	2	187	2	16289958
Pubmed	Sensorimotor gating and spatial learning in α7-nicotinic receptor knockout mice.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	23521765
Pubmed	Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	28258105
Pubmed	The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	19344760
Pubmed	Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease.	INS INS-IGF2	2.88e-05	2	187	2	26203118
Pubmed	Identification of novel diabetes impaired miRNA-transcription factor co-regulatory networks in bone marrow-derived Lin-/VEGF-R2+ endothelial progenitor cells.	INS INS-IGF2	2.88e-05	2	187	2	29995913
Pubmed	Maternal diabetes adversely affects preovulatory oocyte maturation, development, and granulosa cell apoptosis.	INS INS-IGF2	2.88e-05	2	187	2	15718275
Pubmed	Hip1-related mutant mice grow and develop normally but have accelerated spinal abnormalities and dwarfism in the absence of HIP1.	HIP1 HIP1R	2.88e-05	2	187	2	15121852
Pubmed	Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1.	HIP1 HIP1R	2.88e-05	2	187	2	17452370
Pubmed	Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine Receptors.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	29114104
Pubmed	Parental diabetes: the Akita mouse as a model of the effects of maternal and paternal hyperglycemia in wildtype offspring.	INS INS-IGF2	2.88e-05	2	187	2	23209676
Pubmed	Hyper-Variability in Circulating Insulin, High Fat Feeding Outcomes, and Effects of Reducing Ins2 Dosage in Male Ins1-Null Mice in a Specific Pathogen-Free Facility.	INS INS-IGF2	2.88e-05	2	187	2	27055260
Pubmed	Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling.	TNKS TNKS2	2.88e-05	2	187	2	27494558
Pubmed	Tissue- and developmental stage-specific imprinting of the mouse proinsulin gene, Ins2.	INS INS-IGF2	2.88e-05	2	187	2	7729600
Pubmed	Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	24836856
Pubmed	Studies of sperm from mutant mice suggesting that two neurotransmitter receptors are important to the zona pellucida-initiated acrosome reaction.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	15948184
Pubmed	Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	35678315
Pubmed	Impact of genetic background on nephropathy in diabetic mice.	INS INS-IGF2	2.88e-05	2	187	2	16118394
Pubmed	High glucose and diabetes modulate cellular proteasome function: Implications in the pathogenesis of diabetes complications.	INS INS-IGF2	2.88e-05	2	187	2	23391566
Pubmed	Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	12628457
Pubmed	A sensitized screen of N-ethyl-N-nitrosourea-mutagenized mice identifies dominant mutants predisposed to diabetic nephropathy.	INS INS-IGF2	2.88e-05	2	187	2	17151334
Pubmed	Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	22246862
Pubmed	Metabolic effects of short-term caloric restriction in mice with reduced insulin gene dosage.	INS INS-IGF2	2.88e-05	2	187	2	29439088
Pubmed	Hyperglycemia and xerostomia are key determinants of tooth decay in type 1 diabetic mice.	INS INS-IGF2	2.88e-05	2	187	2	22449801
Pubmed	Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes.	INS INS-IGF2	2.88e-05	2	187	2	16936198
Pubmed	Antagonising Wnt/β-catenin signalling ameliorates lens-capsulotomy-induced retinal degeneration in a mouse model of diabetes.	INS INS-IGF2	2.88e-05	2	187	2	30019207
Pubmed	Imprinting at the mouse Ins2 locus: evidence for cis- and trans-allelic interactions.	INS INS-IGF2	2.88e-05	2	187	2	9465295
Pubmed	High fat diet induces brain insulin resistance and cognitive impairment in mice.	INS INS-IGF2	2.88e-05	2	187	2	27771511
Pubmed	Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	1400473
Pubmed	Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ.	INS INS-IGF2	2.88e-05	2	187	2	20825366
Pubmed	Register shifting of an insulin peptide-MHC complex allows diabetogenic T cells to escape thymic deletion.	INS INS-IGF2	2.88e-05	2	187	2	22065673
Pubmed	Activation of Alpha 7 Cholinergic Nicotinic Receptors Reduce Blood-Brain Barrier Permeability following Experimental Traumatic Brain Injury.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	26937017
Pubmed	Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice.	INS INS-IGF2	2.88e-05	2	187	2	15889095
Pubmed	Retinal blood flow abnormalities following six months of hyperglycemia in the Ins2(Akita) mouse.	INS INS-IGF2	2.88e-05	2	187	2	22440813
Pubmed	β-Cell Cre Expression and Reduced Ins1 Gene Dosage Protect Mice From Type 1 Diabetes.	INS INS-IGF2	2.88e-05	2	187	2	36048448
Pubmed	Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	16650968
Pubmed	Long-term improvements in sensory inhibition with gestational choline supplementation linked to α7 nicotinic receptors through studies in Chrna7 null mutation mice.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	24462939
Pubmed	Probing the putative α7 nAChR/NMDAR complex in human and murine cortex and hippocampus: Different degrees of complex formation in healthy and Alzheimer brain tissue.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	29261717
Pubmed	The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells.	SLC39A4 SLC39A5	2.88e-05	2	187	2	15322118
Pubmed	ErbB2 induces Notch1 activity and function in breast cancer cells.	ERBB2 NOTCH1	2.88e-05	2	187	2	20443831
Pubmed	Altered hippocampal circuit function in C3H alpha7 null mutant heterozygous mice.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	18199426
Pubmed	New mouse model to study islet transplantation in insulin-dependent diabetes mellitus.	INS INS-IGF2	2.88e-05	2	187	2	11981430
Pubmed	Both spontaneous Ins2(+/-) and streptozotocin-induced type I diabetes cause bone loss in young mice.	INS INS-IGF2	2.88e-05	2	187	2	22886636
Pubmed	Neuronal nicotinic alpha7 receptors modulate inflammatory cytokine production in the skin following ultraviolet radiation.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	18077004
Pubmed	Smoking in adult attention-deficit/hyperactivity disorder: interaction between 15q13 nicotinic genes and Temperament Character Inventory scores.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	19462340
Pubmed	NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha 7 subunit of a neuronal nicotinic acetylcholine receptor.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	11790782
Pubmed	Diabetic Stroke Severity: Epigenetic Remodeling and Neuronal, Glial, and Vascular Dysfunction.	INS INS-IGF2	2.88e-05	2	187	2	26470785
Pubmed	Quantification of insulin gene expression during development of pancreatic islet cells.	INS INS-IGF2	2.88e-05	2	187	2	19812524
Pubmed	Inhibition of nitric oxide production reverses diabetes-induced Kupffer cell activation and Klebsiella pneumonia liver translocation.	INS INS-IGF2	2.88e-05	2	187	2	28493939
Pubmed	Loss of insulin signaling may contribute to atrial fibrillation and atrial electrical remodeling in type 1 diabetes.	INS INS-IGF2	2.88e-05	2	187	2	32198206
Pubmed	Differential Impact of Chronic Hyperglycemia on Humoral Versus Cellular Primary Alloimmunity.	INS INS-IGF2	2.88e-05	2	187	2	28069641
Pubmed	Genetic deletion of α7 nAChRs reduces hippocampal granule and pyramidal cell number in both sexes but impairs pattern separation in males only.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	37746145
Pubmed	A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	19631623
Pubmed	Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	15770102
Pubmed	Determination of insulin in a single islet of Langerhans by high-performance liquid chromatography with fluorescence detection.	INS INS-IGF2	2.88e-05	2	187	2	12038757
Pubmed	Alpha 7 subunit of nAChR regulates migration of human mesenchymal stem cells.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	20720594
Pubmed	The Ins2Akita mouse as a model of early retinal complications in diabetes.	INS INS-IGF2	2.88e-05	2	187	2	15914643
Pubmed	Calcineurin/NFATc2 and PI3K/AKT signaling maintains β-cell identity and function during metabolic and inflammatory stress.	INS INS-IGF2	2.88e-05	2	187	2	35402865
Pubmed	Chrna7 genotype is linked with alpha7 nicotinic receptor expression but not alpha7 RNA levels.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	19368846
Pubmed	Tissue-specific alternative splicing of mouse brain type ryanodine receptor/calcium release channel mRNA.	RYR2 RYR3	2.88e-05	2	187	2	8898078
Pubmed	Effect of rosiglitazone on liver structure and function in genetically diabetic Akita mice.	INS INS-IGF2	2.88e-05	2	187	2	23789962
Pubmed	Angiography reveals novel features of the retinal vasculature in healthy and diabetic mice.	INS INS-IGF2	2.88e-05	2	187	2	26122048
Pubmed	The role of dorsal root ganglia alpha-7 nicotinic acetylcholine receptor in complete Freund's adjuvant-induced chronic inflammatory pain.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	34514543
Pubmed	α7 nicotinic acetylcholine receptor (α7nAChR) expression in bone marrow-derived non-T cells is required for the inflammatory reflex.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	22183893
Pubmed	Evidence suggesting that the mouse sperm acrosome reaction initiated by the zona pellucida involves an alpha7 nicotinic acetylcholine receptor.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	12606407
Pubmed	Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice.	INS INS-IGF2	2.88e-05	2	187	2	17082643
Pubmed	A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse.	INS INS-IGF2	2.88e-05	2	187	2	9884331
Pubmed	The KINGS Ins2 +/G32S Mouse: A Novel Model of β-Cell Endoplasmic Reticulum Stress and Human Diabetes.	INS INS-IGF2	2.88e-05	2	187	2	32994272
Pubmed	Nicotine elicits prolonged calcium signaling along ventral hippocampal axons.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	24349346
Pubmed	The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors.	RYR2 RYR3	2.88e-05	2	187	2	14550562
Pubmed	Cholinergic modulation of appetite-related synapses in mouse lateral hypothalamic slice.	CHRNA7 CHRFAM7A	2.88e-05	2	187	2	16319313
Interaction	HIF1AN interactions	ANKK1 ANKFY1 ANKRD39 APBA3 CHD1L TUBGCP6 ANKRD44 SYNE2 EHMT1 TNKS TNKS2 ANKRD52 NOTCH1	6.13e-06	317	181	13	int:HIF1AN
GeneFamily	Ankyrin repeat domain containing	ANKRD13B ANKK1 ANKFY1 ANK1 ANKRD39 ESPNL ANKRD26 NFKBIZ ASB12 ANKRD44 TONSL PPP1R16B EHMT1 ANKRD18A TNKS TNKS2 ANKRD52 NOTCH1 ANKRD7	1.15e-15	242	116	19	403
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR2 RYR3	1.22e-04	3	116	2	287
GeneFamily	Protein phosphatase 6 regulatory subunits	ANKRD44 ANKRD52	6.02e-04	6	116	2	699
GeneFamily	Plexins	PLXND1 PLXNB3	1.43e-03	9	116	2	683
GeneFamily	WD repeat domain containing	DMXL2 COPA DCAF12L2 TBL3 DCAF10 PRPF4 WDR6	1.51e-03	262	116	7	362
ToppCell	E18.5-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TET2 ERBB2 INHA FBXL19 ACE2 CD14 ZSCAN22 ZNHIT2	6.91e-07	172	187	8	1bbf5ed7d13635f9a7e528060341e0652699bd7c
ToppCell	droplet-Kidney-nan-21m-Mesenchymal-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF692 RUSC2 NLGN3 METTL25B LRFN4 ZNF276 CPT1C ABCC10	1.10e-06	183	187	8	ad7421623e4c0c5ba02eec56e9bdae43ebb88d90
ToppCell	E12.5-Endothelial\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FLT4 F2RL3 ADAM15 PLXND1 ACVRL1 SOX7 PIK3R6 PPP1R16B	1.30e-06	187	187	8	b8ed57b3c39ffbf750cd08a3e03ec11dae43d00e
ToppCell	Fetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FLT4 ADAM15 PLXND1 ACVRL1 SOX7 RP1L1 PPP1R16B NOTCH1	1.64e-06	193	187	8	ad2df9b77999780860141be6ec366afc0172a331
ToppCell	3'-GW_trimst-1-LargeIntestine-Endothelial-blood_vessel_EC-cycling_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 F2RL3 ADAM15 PLXND1 ACVRL1 SOX7 PIK3R6 PPP1R16B	1.64e-06	193	187	8	807fa1443b3c883cb318c71f4fca3c41d58f4910
ToppCell	10x3'2.3-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast-basophil\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	RASGRP4 INHA NFKBIZ TSEN54 COLGALT2 RYR3 RUSC2 PIK3R6	1.71e-06	194	187	8	5da8873cddff582e5693b32fd3aaebc102f65fc0
ToppCell	3'-GW_trimst-1-LargeIntestine-Endothelial\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 F2RL3 ADAM15 PLXND1 ACVRL1 SOX7 PIK3R6 PPP1R16B	1.91e-06	197	187	8	4623cce5eca0c26c8103950e9874b40918226aa5
ToppCell	3'-GW_trimst-1-LargeIntestine-Endothelial-blood_vessel_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 F2RL3 ADAM15 PLXND1 ACVRL1 SOX7 PIK3R6 PPP1R16B	1.99e-06	198	187	8	96d46e73f968391000ecd14c787efb93c79f96ec
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Perivascular_fibroblast\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HCAR1 SIK1 TFAP2C BMP4 OAF SLIT3 STRA6 KCNK17	2.06e-06	199	187	8	dfc5c7a4a093baa7158dd8d4d29a870d9c469a3f
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Perivascular_fibroblast-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HCAR1 SIK1 TFAP2C BMP4 OAF SLIT3 STRA6 KCNK17	2.06e-06	199	187	8	c1760581c34b81d1d92c67500a1c8944e9cc6dad
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANKRD13B GGT6 FBXL19 ITGB5 OAF SLIT3 STRA6	6.92e-06	167	187	7	805129f887078340b260aa136b0ba19f2bd6ea03
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANKRD13B GGT6 FBXL19 ITGB5 OAF SLIT3 STRA6	6.92e-06	167	187	7	31cf8bf2eb523f6e7e319620648ff37fc09e2601
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANKRD13B GGT6 FBXL19 ITGB5 OAF SLIT3 STRA6	6.92e-06	167	187	7	3acb18428d1d33ad430c2fd031b1a91baee3c01d
ToppCell	AT1-AT2_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	ERBB2 GGT6 HCAR1 PTPN21 NR2F1 FSIP2 ZFHX3	8.39e-06	172	187	7	0be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_D\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	DMXL2 CAND2 FBXL19 NLGN3 ZNF541	8.55e-06	66	187	5	57fd31a25addc48793d7975eadccf4c5a41a8b03
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_D\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	FLT4 ADAM15 ACVRL1 SOX7 SEMA6D PPP1R16B NOTCH1	9.05e-06	174	187	7	b4f3f5334803e5903bc496decf923f2e44f7fa3c
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TET2 ZSWIM8 SIK1 RILP AHDC1 TUBGCP6 ANKRD44	9.39e-06	175	187	7	c1c722db42da9b8a2a46e516ddb83d9be5e2e504
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_PP_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 ANK1 COLGALT2 ACE2 KCNH6 NLGN3 SERPINA7	1.21e-05	182	187	7	eb4be1c02b8b033d025e57b8b4cdbfaec4698054
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	TRPS1 RYR2 RYR3 BMP4 SEMA6D NHS ZFHX3	1.35e-05	185	187	7	7dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 F2RL3 ADAM15 PLXND1 SOX7 PIK3R6 RP1L1	1.35e-05	185	187	7	a987dbf6adf533c5f8a0a8a465a6c8e67e0ffcc8
ToppCell	PCW_05-06-Endothelial-Endothelial_mature-lymphatic\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	FLT4 ADAM15 PLXND1 ACVRL1 SOX7 PIK3R6 PPP1R16B	1.40e-05	186	187	7	86b218a400f9c64f92b050f00b49f09647b17437
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HIP1R PLXND1 ASB12 SOX7 PIK3R6 PANK4 NOTCH1	1.40e-05	186	187	7	055cc23c4db9aad2d6c62e62c8e58bfe5047c6b1
ToppCell	PCW_05-06-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	FLT4 ADAM15 PLXND1 ACVRL1 SOX7 PIK3R6 PPP1R16B	1.40e-05	186	187	7	f51c76b1c3c6c49e0ebc9a913d8413e0b6a04d80
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PAPPA2 TRPS1 RYR3 BMP4 SEMA6D NHS ZFHX3	1.44e-05	187	187	7	5258674d0346e5c51a4b965efcdc1790c970845d
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 ADAM15 PLXND1 ACVRL1 SOX7 PIK3R6 PPP1R16B	1.44e-05	187	187	7	0ef82111b9049cc7ee78d64d240e1f10ab14d6b6
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	TRPS1 COLGALT2 NR2F1 BMP4 SEMA6D NHS ZFHX3	1.44e-05	187	187	7	13731298bc562ec29582f5da1b4c97261284f6f1
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 ADAM15 PLXND1 ACVRL1 SOX7 PIK3R6 NOTCH1	1.44e-05	187	187	7	25efb82afe863a853ecdd781ad89026c993aaa67
ToppCell	droplet-Kidney-KIDNEY-30m-Endothelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIP1 FLT4 ADAM15 PLXND1 ACVRL1 SOX7 NOTCH1	1.55e-05	189	187	7	92319bef1f00d6048ba8f9f8b5c6dbb896686b74
ToppCell	PCW_05-06-Endothelial-Endothelial_cycling-endo_proliferating1_(10)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	FLT4 ADAM15 PLXND1 ACVRL1 SOX7 PIK3R6 PPP1R16B	1.60e-05	190	187	7	9a2244c3973aee7270646bf00db7727edb9decc5
ToppCell	facs-Thymus-Epithelium-24m-Epithelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 ERBB2 INS ACE2 MAPK15 CD14 GP2	1.66e-05	191	187	7	eec14997d2bfc7e6b5a601afc43a147f6b96d668
ToppCell	facs-Thymus-Epithelium-24m-Epithelial-TECs\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 ERBB2 INS ACE2 MAPK15 CD14 GP2	1.66e-05	191	187	7	1730ec5dc1cfd2f0cba7e21555641c7bce97e09d
ToppCell	PCW_05-06-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	FLT4 ADAM15 PLXND1 ACVRL1 SOX7 PIK3R6 PPP1R16B	1.66e-05	191	187	7	e3fc5c92491b6e334abffbf085c00a0b5fa1aed2
ToppCell	facs-Thymus-Epithelium-24m-Epithelial-epithelial_cell_of_thymus\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 ERBB2 INS ACE2 MAPK15 CD14 GP2	1.66e-05	191	187	7	4b77abc68bd72c64e7062f9527fe9d9605289ceb
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 ID4 PLXND1 LIFR SOX7 SEMA6D NOTCH1	1.71e-05	192	187	7	2bfac6b3956265205ca47d06888851ed68b65999
ToppCell	3'-GW_trimst-1-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 ADAM15 PLXND1 ACVRL1 SOX7 PIK3R6 PPP1R16B	1.71e-05	192	187	7	1f35efb0765e05f7f9c881849953bef3965be25a
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 ID4 PLXND1 LIFR SOX7 SEMA6D NOTCH1	1.71e-05	192	187	7	d525f7f088a53110912600a7c9f6d33b9270d534
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 ID4 PLXND1 LIFR SOX7 SEMA6D NOTCH1	1.83e-05	194	187	7	c8b9551b93a5aed62154b487db90130604a6125c
ToppCell	PCW_05-06-Endothelial\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	FLT4 ADAM15 PLXND1 ACVRL1 SOX7 PIK3R6 PPP1R16B	1.83e-05	194	187	7	00291c62795a55a7e63b1db10c139d6a3298e55e
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HIP1 ADAM15 ACVRL1 SOX7 SEMA6D PPP1R16B NOTCH1	1.83e-05	194	187	7	1b382508453c5b08fb617f626b230adf3b6cff99
ToppCell	PCW_05-06-Endothelial-Endothelial_immature\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	FLT4 ADAM15 PLXND1 ACVRL1 SOX7 PIK3R6 PPP1R16B	1.83e-05	194	187	7	9bd25ea57f2da27bd200d1a8bf797fec77d172c7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC11A2 TRPS1 GSAP TFAP2C PRSS36 PIK3R6 CD14	1.83e-05	194	187	7	45708cb2cafde10bf4e4798b81d47c3b1f6aaa14
ToppCell	wk_08-11-Endothelial-Blood_vessel_endothelial-intermediate_cap\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	FLT4 F2RL3 ADAM15 ACVRL1 SOX7 PIK3R6 PPP1R16B	1.89e-05	195	187	7	c0ea25ed1a849e6efff885e98013a4f1d5134758
ToppCell	3'-GW_trimst-1-LargeIntestine-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	F2RL3 ADAM15 PLXND1 ACVRL1 SOX7 PIK3R6 PPP1R16B	1.89e-05	195	187	7	ccfb80e3bfdf5304fa798e0a47b473955ecc0c6d
ToppCell	facs-Thymus-Epithelium-24m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 ERBB2 INS ACE2 MAPK15 CD14 GP2	1.89e-05	195	187	7	cc89261bb091ef978bd73cffc68ccdd00a8786d1
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Macroglial-Glia_progenitor_cell\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	ADAM15 SLC39A4 REPIN1 KCNH6 MAPK15 TRPM8 NOTCH1	1.96e-05	196	187	7	7be50b9156394dea44d7b8b476d4dd516abfafae
ToppCell	wk_08-11-Endothelial\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	FLT4 ADAM15 PLXND1 ACVRL1 SOX7 PIK3R6 PPP1R16B	1.96e-05	196	187	7	0e545874083fd8e954a49fc397d57a86b081008b
ToppCell	Fetal_29-31_weeks-Endothelial\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FLT4 F2RL3 PLXND1 ACVRL1 SOX7 PPP1R16B NOTCH1	1.96e-05	196	187	7	3981f6c7487598f4f7ce4650ac0ac5bd41481d66
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 ADAM15 PLXND1 ACVRL1 SOX7 PIK3R6 PPP1R16B	2.02e-05	197	187	7	98e34e8612f111bb667a574de1faaa785d318ca4
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG\|World / Primary Cells by Cluster	ID4 NFKBIZ TKTL1 ITGB5 TFAP2C PHGDH NOTCH1	2.02e-05	197	187	7	61749ccafeb938c310cff1de5ff924a1c794325a
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 F2RL3 ADAM15 PLXND1 ACVRL1 SOX7 PPP1R16B	2.02e-05	197	187	7	131bc6ef55f467cc802db68daf7e7d757ea64fc6
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG-25\|World / Primary Cells by Cluster	ID4 NFKBIZ TKTL1 ITGB5 TFAP2C PHGDH NOTCH1	2.02e-05	197	187	7	9d4ffa3680f92c91d0a081f9a8ec5ebfec6bdcf6
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 F2RL3 ADAM15 PLXND1 ACVRL1 SOX7 PPP1R16B	2.09e-05	198	187	7	ff8a9adc1302a4679ccdfe9ef95ef53e4c7a5391
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 F2RL3 ADAM15 PLXND1 ACVRL1 SOX7 PPP1R16B	2.09e-05	198	187	7	09e452742aed9f48bf1ffc35c6b06a296bcfe076
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-cycling_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 F2RL3 ADAM15 PLXND1 ACVRL1 SOX7 PPP1R16B	2.09e-05	198	187	7	37d6557833877fc2ff51fbeb589e3eb832dbef5f
ToppCell	3'-Child04-06-SmallIntestine-Endothelial\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 F2RL3 ADAM15 PLXND1 ACVRL1 LIFR SOX7	2.09e-05	198	187	7	bf4e086c3fc924e999b6eaca87d2beee9b9526c2
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 F2RL3 ADAM15 PLXND1 ACVRL1 SOX7 NOTCH1	2.16e-05	199	187	7	f0bf75bfae7b288ecb6801be458b03ebd0108ea7
ToppCell	E16.5-samps-Endothelial-Immature_fetal_endothelial-Matrix_Endothelial\|E16.5-samps / Age Group, Lineage, Cell class and subclass	FLT4 PLXND1 ACVRL1 SOX7 C17orf50 PPP1R16B	4.80e-05	154	187	6	928f49839b046b90c2f942458f3e365ddc4e0bc9
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 F2RL3 PLXND1 ACVRL1 SOX7 TONSL	5.93e-05	160	187	6	33050dc646762dc7e9dcc4a12c618e1ba1ce5a4d
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_STALK\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	RASGRP4 FLT4 ACVRL1 SOX7 PIK3R6 STRA6	5.93e-05	160	187	6	04714d0b9bad4c11fa193ed168e2d84a4df39e2e
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	F2RL3 ADAM15 RYR3 SOX7 ZNF469 PPP1R16B	6.36e-05	162	187	6	c399b9e4854916a59f5cae2d8dbf19660f8759be
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	F2RL3 ADAM15 RYR3 SOX7 ZNF469 PPP1R16B	6.36e-05	162	187	6	a291248b693c771845174393934a782f1d8bd7ce
ToppCell	343B-Myeloid-Dendritic-cDC_proliferating_2\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	ZSWIM8 ERBB2 DMXL2 ANKRD39 ITGB5 NOP14	6.80e-05	164	187	6	d7053de88ef8e42cac6726a40e72f212659ee034
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_STALK\|Cerebellum / BrainAtlas - Mouse McCarroll V32	FLT4 KCP ACVRL1 SOX7 PIK3R6 STRA6	7.04e-05	165	187	6	7d319a112b9062efee428bef6f4534d2ce782e04
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-B_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PAOX ANKRD44 CD22 PPP1R16B KCNK17 IL9R	7.04e-05	165	187	6	7039bb5a7af4684fbd1192230864e5cd6936e83c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-B_Cell-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PAOX ANKRD44 CD22 PPP1R16B KCNK17 IL9R	7.04e-05	165	187	6	d2c79653710b139794170f3d72f11392fc548ac7
ToppCell	356C-Fibroblasts-Fibroblast-D\|356C / Donor, Lineage, Cell class and subclass (all cells)	SCARF2 NR2F1 RYR2 NLGN3 PRR19 SLIT3	7.28e-05	166	187	6	7286a37b2827f3747469ffd0d76cbe81116db7ee
ToppCell	356C-Fibroblasts-Fibroblast-D-\|356C / Donor, Lineage, Cell class and subclass (all cells)	SCARF2 NR2F1 RYR2 NLGN3 PRR19 SLIT3	7.28e-05	166	187	6	7c2eee0a4f45795a956acf936b85bdb35f1b1624
ToppCell	Endothelial-B-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	FLT4 NR2F1 RYR2 SOX7 C9orf43 OAF	7.52e-05	167	187	6	6a03d16165e0b003092c39972928981abd4a75aa
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ACVRL1 RYR2 PTRH1 ZFHX3 ANKRD52	8.11e-05	105	187	5	8f31edf4183587f5b53941475453c5aa49f10bbd
ToppCell	P15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	INHA PEX6 PRSS36 PHGDH ZSCAN22 SERGEF	8.30e-05	170	187	6	ba4ba66b624089ed50a9083176386c7941b4c7a3
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CHDH HIP1R PIDD1 TFAP2C KCNH6 SERPINA7	8.30e-05	170	187	6	2c5a1469e5743870e96e6c2cc92f0c5096b79f51
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CHDH HIP1R PIDD1 TFAP2C KCNH6 SERPINA7	8.30e-05	170	187	6	9bea81031cdfe45e8cddac3a3afd9ca6c331c45a
ToppCell	E12.5-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FLT4 PLXND1 ACVRL1 SOX7 PIK3R6 PPP1R16B	8.85e-05	172	187	6	ba99688e9f46671deccf824b1e77c6db0742d7df
ToppCell	E12.5-Endothelial-proliferative_endothelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FLT4 PLXND1 ACVRL1 SOX7 PIK3R6 PPP1R16B	8.85e-05	172	187	6	2136170f6e1204734cec7dbf7b32e7d5179b92b5
ToppCell	droplet-Heart-4Chambers-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP INS ESPNL PLXND1 SOX7 PPP1R16B	9.14e-05	173	187	6	9a04271c51fae34f547db3206f9ff5857686e45c
ToppCell	TCGA-Colorectal-Recurrent_Tumor\|TCGA-Colorectal / Sample_Type by Project: Shred V9	CPN2 GPR88 SERPINA11 MLIP TRPM8 INS-IGF2	9.73e-05	175	187	6	7f74961436f88c0e380819095e6104489914d765
ToppCell	TCGA-Colorectal-Recurrent_Tumor-Colorectal_Adenocarcinoma\|TCGA-Colorectal / Sample_Type by Project: Shred V9	CPN2 GPR88 SERPINA11 MLIP TRPM8 INS-IGF2	9.73e-05	175	187	6	bee8f31f036dfcf9fc6ed29156554771a9ee3c60
ToppCell	facs-Pancreas-Endocrine-18m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 F2RL3 ACVRL1 SOX7 PIK3R6 PPP1R16B	1.00e-04	176	187	6	9ddf87e586d2378984cd007c60f7dc254845f8f3
ToppCell	facs-Pancreas-Endocrine-18m-Endothelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 F2RL3 ACVRL1 SOX7 PIK3R6 PPP1R16B	1.00e-04	176	187	6	e987e741fcf1bed8598a5060700efd3018f8123b
ToppCell	facs-Pancreas-Endocrine-18m-Endothelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 F2RL3 ACVRL1 SOX7 PIK3R6 PPP1R16B	1.00e-04	176	187	6	92ebcea9b2b22601234b76d7a98f0410b905a87b
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-MAIT_cell\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TCAF2 FLYWCH1 PLXND1 TSPAN32 PPP1R16B ZNHIT2	1.07e-04	178	187	6	0290868dc990878eac5c182fe64968333bc52450
ToppCell	human_hepatoblastoma-Tumor_cells-T6\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	TET2 TRPS1 COLGALT2 RYR2 PPP1R16B NHS	1.10e-04	179	187	6	14fc8ccb6b215063d747643f47d780d2b237eb67
ToppCell	5'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	F2RL3 ADAM15 PLXND1 SOX7 PIK3R6 PPP1R16B	1.14e-04	180	187	6	af7c4b9f1a0ddd894085cf93c29a6d253a7d077c
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 F2RL3 ADAM15 PLXND1 ACVRL1 SOX7	1.14e-04	180	187	6	755050226eeb1991ee7f0d15e39d0458f3e4a791
ToppCell	5'-GW_trimst-1-SmallIntestine-Endothelial\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	F2RL3 ADAM15 PLXND1 SOX7 PIK3R6 PPP1R16B	1.14e-04	180	187	6	e35e9159f5cd9ec905b3b6e27d938158aeb9c51c
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK1 INS ASB12 RYR2 MLIP FBXO44	1.17e-04	181	187	6	09a574a3257e25c8b05a2ab20623a6b07331411a
ToppCell	5'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	F2RL3 ADAM15 PLXND1 SOX7 PIK3R6 PPP1R16B	1.17e-04	181	187	6	7d7d1edeae4e0ebe40b324d1231cd26e27ba9d42
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK1 INS ASB12 RYR2 MLIP FBXO44	1.17e-04	181	187	6	ac4142aa93706b7067f63d2d38e2456859e60768
ToppCell	droplet-Mammary_Gland-nan-18m-Endothelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT4 ADAM15 COLGALT2 LIFR SOX7 GP2	1.17e-04	181	187	6	2e15c46e8260bb04d8264478c19a707221996026
ToppCell	E16.5-samps-Endothelial-Immature_fetal_endothelial-Intermediate_Endothelial\|E16.5-samps / Age Group, Lineage, Cell class and subclass	FLT4 ADAM15 ACVRL1 RYR2 PIK3R6 PPP1R16B	1.21e-04	182	187	6	fec1caf867b1dc87b24504d895ee1a27df78062e
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-7\|TCGA-Prostate / Sample_Type by Project: Shred V9	TOR2A SLC12A8 CHD1L SSPOP REPIN1 SND1	1.21e-04	182	187	6	af16334fec2c757b03c84cf252d00e92fa81e4cd
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAM15 PLXND1 ACVRL1 LIFR SOX7 PIK3R6	1.24e-04	183	187	6	52af3c943116073c8ddd207b664342960b88929b
ToppCell	wk_08-11-Endothelial-Blood_vessel_endothelial-Late_cap\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	FLT4 F2RL3 ADAM15 PLXND1 ACVRL1 SOX7	1.24e-04	183	187	6	3e69cc605f166a1f04e3d077935f7cfd806f1ffd
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KCP ITGB5 NR2F1 RYR2 SEMA6D ZFHX3	1.28e-04	184	187	6	689a8af81a79a4bb3123cfa01958c953eab5de98
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFKBIZ SIK1 BIRC6 SLF2 XRN1 ASCC3	1.28e-04	184	187	6	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 HIP1 ITGB5 SEMA6D NHS GP2	1.28e-04	184	187	6	e8238fe58f94b4f5700ab7f343fb06ea61e899a9
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK-ILC\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TTC24 TKTL1 PPP1R16B TRPM8 IL9R	1.30e-04	116	187	5	f7f0cd61723c94586504b656a8d4e098e98d8e23
ToppCell	E12.5-Endothelial-capillary_endothelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	F2RL3 ADAM15 PLXND1 ACVRL1 SOX7 PPP1R16B	1.32e-04	185	187	6	e005d3c01a908157f780bbc1d53dd2ed814a39d2
ToppCell	droplet-Liver-HEPATOCYTES-1m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP FLT4 COLGALT2 PLXND1 LIFR PIK3R6	1.32e-04	185	187	6	742350093d90f96735dc73e3360cdd749bae63fd
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DAB2IP KCP ITGB5 RYR2 SEMA6D KCNK17	1.32e-04	185	187	6	a7dba7db79275884b2a93d8a16f2e0c739e71370
Drug	Carbarsone [121-59-5]; Down 200; 15.4uM; MCF7; HT_HG-U133A	ZSWIM8 ERBB2 PIDD1 SIK1 GSAP PAOX SND1 EHMT1 ZNF552 TNKS SLC26A6	6.00e-07	197	183	11	3250_DN
Drug	Azathioprine [446-86-6]; Down 200; 14.4uM; MCF7; HT_HG-U133A	PAPPA2 FLT4 ANKRD26 GSAP ITGB5 NR2F1 PAOX BMP4 ZFHX3 ARHGEF4	4.84e-06	198	183	10	5262_DN
Disease	Sclerocystic Ovaries	FLT4 CARMIL3 INS CAMK2D LIFR FBXO44 TONSL	2.64e-05	144	176	7	C1136382
Disease	Polycystic Ovary Syndrome	FLT4 CARMIL3 INS CAMK2D LIFR FBXO44 TONSL	2.64e-05	144	176	7	C0032460
Disease	SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 3	PEX6 SLC52A2	3.54e-05	2	176	2	C1849094
Disease	Cakut	CHD1L LIFR BMP4	5.71e-05	13	176	3	C1968949
Disease	risky sexual behaviour measurement	TET2 BIRC6 SOX7 SEMA6D SND1 ZFHX3 ASCC3	7.30e-05	169	176	7	EFO_0007877
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR2 RYR3	1.06e-04	3	176	2	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR2 RYR3	1.06e-04	3	176	2	DOID:8545 (implicated_via_orthology)
Disease	alcoholic liver cirrhosis, alcoholic pancreatitis, alcohol dependence	PHGDH PPP1R16B	1.06e-04	3	176	2	EFO_1000802, EFO_1002013, MONDO_0007079
Disease	peritonsillar abscess	TET2 NFKBIZ SLC12A8	1.59e-04	18	176	3	EFO_0007429
Disease	heart failure, diabetes mellitus, stroke, atrial fibrillation, mortality, coronary artery disease, cancer	ANKRD26 POLR1F ZFHX3	2.21e-04	20	176	3	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004352, MONDO_0004992
Disease	X-24020 measurement	TUBGCP6 PAOX	3.50e-04	5	176	2	EFO_0022128
Disease	Paroxysmal atrial fibrillation	CAND2 CAMK2D HIP1R SYNE2 SLIT3 ZFHX3	3.59e-04	156	176	6	C0235480
Disease	familial atrial fibrillation	CAND2 CAMK2D HIP1R SYNE2 SLIT3 ZFHX3	3.59e-04	156	176	6	C3468561
Disease	Persistent atrial fibrillation	CAND2 CAMK2D HIP1R SYNE2 SLIT3 ZFHX3	3.59e-04	156	176	6	C2585653
Disease	blood urea nitrogen measurement	KCP ACVRL1 NMD3 BMP4 ZNF276 SLF2 FAM53B ASCC3 INS-IGF2 ABCC10	4.08e-04	452	176	10	EFO_0004741
Disease	Atrial Fibrillation	CAND2 CAMK2D HIP1R SYNE2 SLIT3 ZFHX3	4.11e-04	160	176	6	C0004238
Disease	cognitive disorder (implicated_via_orthology)	CHRNA7 CHRFAM7A	5.22e-04	6	176	2	DOID:1561 (implicated_via_orthology)
Disease	rheumatoid arthritis (biomarker_via_orthology)	CHRNA7 CHRFAM7A	5.22e-04	6	176	2	DOID:7148 (biomarker_via_orthology)
Disease	age at diagnosis, substance-related disorder	BIRC6 SEMA6D	5.22e-04	6	176	2	EFO_0004918, MONDO_0002494
Disease	calcinosis (is_marker_for)	ERBB2 BMP4	5.22e-04	6	176	2	DOID:182 (is_marker_for)
Disease	risk-taking behaviour	PAPPA2 TET2 ADAM15 BIRC6 RYR2 SEMA6D SND1 RP1L1 LINC00208 ZFHX3 TNKS ASCC3 ANKRD52	7.08e-04	764	176	13	EFO_0008579
Disease	Malignant neoplasm of breast	ERBB2 ANK1 SCARF2 COLGALT2 NR2F1 PHGDH BMP4 SYNE2 EHMT1 NHS ZFYVE26 ARHGEF4 ZNHIT2 VPS13B NOTCH1 ZNF541	7.39e-04	1074	176	16	C0006142
Disease	total cholesterol measurement, hematocrit, stroke, ventricular rate measurement, body mass index, atrial fibrillation, high density lipoprotein cholesterol measurement, coronary artery disease, diastolic blood pressure, triglyceride measurement, systolic blood pressure, heart failure, diabetes mellitus, glucose measurement, mortality, cancer	NRBP1 ANKRD26 POLR1F ZFHX3	7.82e-04	69	176	4	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004340, EFO_0004348, EFO_0004352, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928, MONDO_0004992
Disease	intestinal cancer (implicated_via_orthology)	ERBB2 SOX7 NOTCH1	9.11e-04	32	176	3	DOID:10155 (implicated_via_orthology)
Disease	heart conduction disease (implicated_via_orthology)	CAMK2D KCNH6 KCNK17	9.11e-04	32	176	3	DOID:10273 (implicated_via_orthology)
Disease	creatinine measurement	TET2 EEFSEC NRBP1 CAND2 INS BIRC6 BMP4 MLIP SND1 SLF2 FAM53B ZFHX3 ASCC3 INS-IGF2 ABCC10	9.61e-04	995	176	15	EFO_0004518
Disease	esophagus squamous cell carcinoma (is_marker_for)	DAB2IP TET2 CHRNA7 EHMT1	1.02e-03	74	176	4	DOID:3748 (is_marker_for)
Disease	uric acid measurement	TET2 FLT4 POLR1A DCAF12L2 BIRC6 ZNF276 MLIP FAM53B KCNK17 ANKRD52 INS-IGF2	1.15e-03	610	176	11	EFO_0004761
Disease	latent autoimmune diabetes in adults, type 2 diabetes mellitus	INS INS-IGF2	1.24e-03	9	176	2	EFO_0009706, MONDO_0005148
Disease	body weights and measures	ID4 SEMA6D INS-IGF2	1.51e-03	38	176	3	EFO_0004324
Disease	Aortic Aneurysm, Abdominal	DAB2IP ACE2	1.54e-03	10	176	2	C0162871
Disease	corpus callosum anterior volume measurement	TRPS1 POLR1F SND1	1.63e-03	39	176	3	EFO_0010295
Disease	amino acid metabolic disorder (is_implicated_in)	HMGCL PHGDH	1.88e-03	11	176	2	DOID:9252 (is_implicated_in)
Disease	Diabetic Cardiomyopathies	INS RYR2	1.88e-03	11	176	2	C0853897
Disease	pericalcarine cortex volume measurement	TSPAN32 SEMA6D	1.88e-03	11	176	2	EFO_0010322
Disease	Diaphragmatic Hernia	BMP4 SLIT3 STRA6	1.88e-03	41	176	3	C0019284
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	TET2 ERBB2 FLT4 PIDD1 SYNE2	1.98e-03	148	176	5	C0279702
Disease	congenital diaphragmatic hernia (implicated_via_orthology)	SOX7 SLIT3	2.24e-03	12	176	2	DOID:3827 (implicated_via_orthology)
Disease	nicotine dependence (implicated_via_orthology)	CHRNA7 CHRFAM7A	2.24e-03	12	176	2	DOID:0050742 (implicated_via_orthology)
Disease	Connective Tissue Diseases	ZNF469 NOTCH1	2.64e-03	13	176	2	C0009782
Disease	birth weight	PAPPA2 TET2 ANK1 ID4 ZNF469 SND1 XRN1 INS-IGF2	2.83e-03	399	176	8	EFO_0004344
Disease	wellbeing measurement	ANKK1 CAND2 ACVRL1 SEMA6D SND1 UCKL1 RP1L1 FAM53B ZFHX3 TNKS ASCC3	3.06e-03	692	176	11	EFO_0007869
Disease	Arthritis, Psoriatic	FBXL19 BMP4	3.07e-03	14	176	2	C0003872
Disease	anemia (is_implicated_in)	SLC11A2 ANK1	3.07e-03	14	176	2	DOID:2355 (is_implicated_in)
Disease	developmental disorder of mental health (implicated_via_orthology)	DAB2IP PLXND1 PLXNB3	3.14e-03	49	176	3	DOID:0060037 (implicated_via_orthology)
Disease	alkaline phosphatase measurement	TET2 KCP APBA3 SLC39A4 MLIP SLF2 UCKL1 RP1L1 TONSL LINC00208 TNKS TNKS2 NOTCH1 ABCC10	3.18e-03	1015	176	14	EFO_0004533
Disease	P wave duration	CAND2 CAMK2D	3.53e-03	15	176	2	EFO_0005094
Disease	cardioembolic stroke	ANK1 CAMK2D DCAF12L2 SYNE2 ZFHX3	3.60e-03	170	176	5	EFO_1001976
Disease	generalised epilepsy	ACVRL1 RYR2 PADI6	3.72e-03	52	176	3	EFO_0005917
Disease	myopia (is_implicated_in)	CPSF1 SLC39A5	4.02e-03	16	176	2	DOID:11830 (is_implicated_in)
Disease	ulcerative colitis	TET2 KCP NFKBIZ SEMA6D SLIT3 INTS11 NOTCH1	4.11e-03	335	176	7	EFO_0000729
Disease	pulse pressure measurement	PAPPA2 TET2 HIP1 TRPS1 FTMT FBXL19 SSPOP AHDC1 ITGB5 MLIP SND1 SLIT3 INTS11 LINC00208 FAM53B ZFHX3 ABCC10	4.14e-03	1392	176	17	EFO_0005763
Disease	hemoglobin A1 measurement	TET2 ANK1 TRPS1 SLC12A8 GSAP PLXND1 SOX7 RP1L1 SYNE2	4.16e-03	520	176	9	EFO_0007629
Disease	cortical thickness, neuroimaging measurement	NR2F1 POLR1F SND1 FAM53B	4.32e-03	110	176	4	EFO_0004346, EFO_0004840
Disease	sphingomyelin 14:0 measurement	SYNE2 ZFHX3	4.54e-03	17	176	2	EFO_0010390
Disease	cervical carcinoma	CAMK2D GSAP FSIP2 TNKS INS-IGF2	4.81e-03	182	176	5	EFO_0001061
Disease	Tachycardia	INS RYR2	5.08e-03	18	176	2	C0039231
Disease	Tachyarrhythmia	INS RYR2	5.08e-03	18	176	2	C0080203
Disease	osteochondrodysplasia (is_implicated_in)	TRPS1 LIFR	5.66e-03	19	176	2	DOID:2256 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
HCAADLALAPLGDAQ	PTRH1	71	Q86Y79
GEPEIGSLCASHVLH	LINC00208	36	Q96KT6
HQALNGFHPAPLCTI	ARMT1	386	Q9H993
LGSGLALIHHNTHLC	ERBB2	461	P04626
AHTPCLVGLSLTHNQ	CPN2	286	P22792
PLEGTSHCHINLNET	ANKRD18A	641	Q8IVF6
SDLLLPHAHALDAAG	TFAP2C	146	Q92754
PHAHALDAAGLAENL	TFAP2C	151	Q92754
RLHPEKDHGDLLASC	BIRC6	4026	Q9NR09
LGLLAHQVHDGACFR	ACOX3	466	O15254
ISRIQDLHLPGHTCA	ADAM15	166	Q13444
DELTPLHCAARNGHV	ANK1	271	P16157
QQPDLCALLLAHGAD	ANKK1	406	Q8NFD2
PHLSELGACFLEHQA	ARHGEF4	356	Q9NR80
CPLHIATGHGLASQE	APBA3	81	O96018
RLAVSAACGLAHLHV	ACVRL1	301	P37023
ALHLACANGHPEVVA	ANKRD26P1	86	Q6NSI1
FHLNDLACHSVLPLL	DMXL2	651	Q8TDJ6
HAAAAQAHLSCRDLP	AHDC1	1436	Q5TGY3
RTALHLACANGHPEV	ANKRD26	81	Q9UPS8
GHGDICSLLLQHSPA	ANKRD39	141	Q53RE8
VSPLHLAAYNGHCEA	ANKRD52	586	Q8NB46
CPFPLADHLNSTNHA	BMP4	341	P12644
ACSPTHDEHLLHGGQ	CHRNA7	411	P36544
HPLHCAFLEATQQAG	CHDH	196	Q8NE62
APQLSALDLSHCAHV	FBXL19	596	Q6PCT2
HCAHVGDPSVHLLTA	FBXL19	606	Q6PCT2
SLLHPQTLSHADCLA	MLIP	396	Q5VWP3
ALHEHLCLGASAAPE	RILP	386	Q96NA2
LHVAPLLAAAGLHAS	NR2F1	271	P10589
PAAAFVNQHLCGSHL	INS	21	P01308
PLHLATTLGHLECAR	ANKRD13B	51	Q86YJ7
GETPLHTACRHGLAN	ANKFY1	491	Q9P2R3
HTACRHGLANLTAEL	ANKFY1	496	Q9P2R3
HITNHYLGLCAALEP	DAB2IP	351	Q5VWQ8
GHCFTQLVLSALPHA	ABCC10	26	Q5T3U5
HLSLDSPVHAVCVLG	PADI6	16	Q6TGC4
VRAPGAQSLAHALAH	TCTE1	346	Q5JU00
GASPLYLACQEGHLH	ESPNL	171	Q6ZVH7
ENELACAGHLPEKLH	KATNBL1	101	Q9H079
CPHGRTGLLCHLNDA	NOTCH1	361	P46531
FHLLHQLPGCAAAAA	GPR88	231	Q9GZN0
DGLTPLHCAVIAHNA	NFKBIZ	551	Q9BYH8
HADLHGATSCVIKNP	NEMF	566	O60524
HHEAIPICHGNLIFL	NPY4R	291	P50391
SVLKDHCVQHLPDGS	INTS11	536	Q5TA45
GTVCHSALGHLPLLE	MAPK15	526	Q8TD08
HCHQPDLAGLEALRQ	FLYWCH1	656	Q4VC44
HLSCLQVLLAHGADV	ASB12	76	Q8WXK4
GFPECLQADICLHLH	KCNH6	571	Q9H252
AHQGCGIHAIELNPS	DCAF12L2	146	Q5VW00
GSCVLHALTLSHNPI	CARMIL3	271	Q8ND23
HHSLCPAEELALEAL	CCDC120	101	Q96HB5
ENHLQPFLSGEVLCH	FSIP2	4256	Q5CZC0
PVTALCHCNGHLVSA	CPSF1	1171	Q10570
VLSSPCDQAGLHHRF	FAM53B	176	Q14153
EDSHCLHIQSLLPGH	PLXNB3	521	Q9ULL4
EQLDCGAAHLQHPLS	PLXND1	441	Q9Y4D7
IQHLEPSAHAAGCGK	KCNK17	316	Q96T54
AAACSHLGLHLLKVP	PEX6	481	Q13608
ESDHGNCITSLQLHP	DCAF10	406	Q5QP82
SLHRNLLHNPCAEEG	FBXO44	76	Q9H4M3
PALGDGITNHTACAH	GP2	126	P55259
ECHLPGLGVALTLDH	INTS2	271	Q9H0H0
HPPCSANEDLLHLLT	RASGRP4	396	Q8TDF6
GHTCHLGLTAQPELY	SLC11A2	541	P49281
LQCSLHGDTPHASNL	TUBGCP6	1566	Q96RT7
VARGCPSLEHLALSH	LRRC29	121	Q8WV35
VHHASPGCVNQDLLD	MROH6	626	A6NGR9
GLHACGDLSVALLRH	METTL25B	256	Q96FB5
TPLHCAIINDHGNCA	ANKRD44	806	Q8N8A2
TPLHAAAFADHVECL	ANKRD44	841	Q8N8A2
GELALRCLAEHGHSL	ID4	21	P47928
QALLTDHLADCSHPQ	NOP14	716	P78316
LLHSGKPDNQTCHSL	ITGB5	646	P18084
ACSPTHDEHLLHGGQ	CHRFAM7A	321	Q494W8
LHLTLANVGHPCEQK	NPHP4	821	O75161
PSLKLLAAHCIVGHQ	NRBP1	331	Q9UHY1
IREHAQLPSPAAAHC	PTPN21	496	Q16825
NDIGQLACLHARLHS	PANK4	301	Q9NVE7
VLCHDALPLDAQASH	F2RL3	226	Q96RI0
TPLHAAATCGHINLV	PPP1R16B	136	Q96T49
PHTEHGACGLRLEAA	PRSS36	581	Q5K4E3
EELAALQLGPTHHEC	NLGN3	761	Q9NZ94
LLLPHCLQDNHDVGT	PAPPA2	1536	Q9BXP8
PACPHEEHLAALTAA	CPT1C	371	Q8TCG5
LLHLQSCGDLHTFTP	FAM189A2	406	Q15884
PLHNLLHCIDSGVLL	GSAP	711	A4D1B5
CAALAAAGVQPHSLD	CD14	241	P08571
DALHRSPCVAASQHG	CRNKL1	61	Q9BZJ0
KLHSCLPADTLQGHR	HIP1R	236	O75146
GPDHLDHLLLDTQHC	LINC01555	16	Q8NAE3
ACPAPSSAAHQLEHL	CPLANE1	2686	Q9H799
VLAAHPNLNLFAAGH	COPA	296	P53621
GAALCLAVVHPHATG	GGT6	131	Q6P531
ILDSGFAAHHLPECT	C9orf43	61	Q8TAL5
LHLELGQPAAAAALC	F8A1;	131	P23610
HPQAGAEDALIVHCV	CHD1L	726	Q86WJ1
LHGALPDARGCHIAQ	IFNL2	31	Q8IZJ0
QEALCQAAKHEGPLH	ACE2	526	Q9BYF1
TPLHLACANGHTDVV	ANKRD7	61	Q92527
AHCVLDHPDLGKAGA	C17orf50	156	Q8WW18
PAAHANCHRVALNIS	INHA	256	P05111
ACDPSVHGALHITLS	HCAR1	251	Q9BXC0
ARNAAHTLPHFLGCL	COLGALT2	61	Q8IYK4
AFHASLLHCLLPQLS	CAND2	171	O75155
GLHCSEHLLLEKAPS	SLC12A8	426	A0AV02
CAPLFAGTEHHASLI	RYR2	2531	Q92736
PLHAAAEAGHVDICH	EHMT1	776	Q9H9B1
NCTLSIHPVHLNDSG	CD22	101	P20273
ELHALASDKGDPHLC	FTMT	176	Q8N4E7
PAAAFVNQHLCGSHL	INS-IGF2	21	F8WCM5
NPHVHLVGDDAACIA	CAMK2D	416	Q13557
LIGHTNCPLIHLDGE	LIFR	281	P42702
SHNCLSELPEALGAL	PIDD1	156	Q9HB75
LGAAQRLCGHSAFPH	PAOX	26	Q6QHF9
SLDCDLPQTHSLGHR	IFNA6	21	P05013
EVQALCHHLATGPGQ	RUSC2	1451	Q8N2Y8
LHCSHPLGSLALGQS	SOX7	251	Q9BT81
CGAGHSLALCQLPAH	SERGEF	391	Q9UGK8
QLLPQHTLAAKGDHC	TIGD6	186	Q17RP2
FSNCSGHLGHIELPL	POLR1A	71	O95602
LECGSIHLFHQDLPL	TSEN54	121	Q7Z6J9
SPCAGLCATHLSHQL	SSPOP	4436	A2VEC9
GLECDLAQHLAGQHL	TOR2A	51	Q8N2E6
QSLCHLVAPGHERSG	SYNE2	6391	Q8WXH0
EHGLQCSLEPHLNSD	TCAF2	316	A6NFQ2
DHQPTLGLACSQHLH	NHS	556	Q6T4R5
PDCNLLHTLRGHNTN	PRPF4	261	O43172
AACHSPVVSQLEAGH	SLC26A6	706	Q9BXS9
TCFNQHIPLGELAAH	KCP	1501	Q6ZWJ8
PLAALAVHCHDTYGQ	HMGCL	226	P35914
LGEACHAGALHRKLQ	PIK3R6	201	Q5UE93
LHSCLPADTLQGHRD	HIP1	246	O00291
HLAVVLGSAANPLAC	SLC52A2	311	Q9HAB3
GLATSLAVFCHELPH	SLC39A4	526	Q6P5W5
LQLQHHPAAAPGCSQ	SIK1B	661	A0A0B4J2F2
LQLQHHPAAAPGCSQ	SIK1	661	P57059
CLLNVEHLSAGCPHV	SND1	826	Q7KZF4
EHLSAGCPHVTLQFA	SND1	831	Q7KZF4
ELCLGINELSSHPHN	SLF2	981	Q8IX21
LAGHCQRPGLHEDLQ	IL9R	491	Q01113
GALLSPHLHNVCAEA	OAF	151	Q86UD1
LAACATAGHTAAHLL	STRA6	161	Q9BX79
VHAAATPDLGFACHL	REPIN1	106	Q9BWE0
TLCGDALLHLLPHAQ	SLC39A5	256	Q6ZMH5
VLLLHACAHNPTGVD	GOT2	206	P00505
HTLYHTDCNVLLGAP	ASCC3	1336	Q8N3C0
HLALGTNPLHCDCSL	SLIT3	851	O75094
GLECDLAQHLAGQHL	TOR2A	51	Q5JU69
NCSHCALLLLHLSPG	TRPS1	591	Q9UHF7
GLVCAPESLHTVHAA	EEFSEC	301	P57772
NSALELPSVHFLCGH	VPS11	826	Q9H270
LCFLPGTVNHSHHLA	TTC24	486	A2A3L6
LHSPSVLVCAGHEAF	RP1L1	211	Q8IWN7
HTLQACHGCVPDLAL	PRR19	176	A6NJB7
TGILASVHCQPLLAH	SERPINA11	11	Q86U17
SVHCQPLLAHGDKSL	SERPINA11	16	Q86U17
LALGCHIAHVNPAAE	RYR3	931	Q15413
QGGPTHCLHSEAVAI	TSPAN32	256	Q96QS1
PGQELTHCTLAHTAG	TBL3	291	Q12788
EAALCHQLGELLAGH	TONSL	26	Q96HA7
CEGITPLHDALNCGH	TONSL	596	Q96HA7
PLHDALNCGHFEVAE	TONSL	601	Q96HA7
EGCALAHLTLSANHL	TONSL	1246	Q96HA7
HHDLDNTLNCSFLEP	SCARF2	521	Q96GP6
TQLCALLLAHGADPT	TNKS	916	O95271
HLHALQPEDSALYLC	TRBV4-1	96	A0A577
STLHDAHGNPLLLDC	FLT4	596	P35916
VLGLHATIHCASPEG	SERPINA7	11	P05543
HAASCGALPHLQRTL	ZNF276	206	Q8N554
LSNGLLVHGPQCHSE	XRN1	1476	Q8IZH2
HHEAIPICHGNLIFL	NPY4R2	291	P0DQD5
GAHAPLLALCHVDGR	SLC35A4	31	Q96G79
SCLVAGPHQRHIALS	POLR1F	46	Q3B726
LQAHSCGINSLHTLP	WDR6	976	Q9NNW5
PCAHAAHVTGLKILS	WDR6	1041	Q9NNW5
LLGNHSGVCLANLHD	PSME4	1031	Q14997
GLIPLHNACSFGHAE	TNKS2	91	Q9H2K2
FHPGHAALLPCAQED	ZNF469	1636	Q96JG9
SGPHEALAHLRALCC	ZSCAN22	61	P10073
RAAAELALSCLPHAH	ZSWIM8	1356	A7E2V4
LALSCLPHAHALNPN	ZSWIM8	1361	A7E2V4
PLALDCARAHQAHAV	ZNHIT2	356	Q9UHR6
CGPILGDILHVADHQ	ZNF552	96	Q9H707
HLCHHLDQLGTAAPQ	VPS13B	2491	Q7Z7G8
SVRAALASAHQCHPL	UCKL1	306	Q9NWZ5
DCHEKPLNLSVGALH	ZNF217	681	O75362
ALVDHENVISCPHLG	PHGDH	271	O43175
LCHITSGEALPLDHT	ZFAND1	216	Q8TCF1
LLVDNGCHGHPTVEA	TRPM8	261	Q7Z2W7
DVTQGLPHAHSACLE	VEZT	376	Q9HBM0
NTAHLGDCHEILPTS	SEMA6D	561	Q8NFY4
DHLPKAHVQSLCGTR	TET2	666	Q6N021
SQNGFLHLLLHGCDL	UHRF1BP1	1276	Q6BDS2
LAQLHASHCLDDLPL	ZFYVE26	1256	Q68DK2
NRLGHSGALPAEHCI	TKTL1	156	P51854
GCRLHSAPNLSDLHV	ULK1	551	O75385
LSHAHSRECSLVPGL	ZNF692	86	Q9BU19
GGTNLELALHCLHEA	ZNF541	1116	Q9H0D2
FVPHHQHAGSLCELG	ZFHX3	616	Q15911
EGCSPDHTIILLAHQ	TMPPE	356	Q6ZT21
PASPLCHALQAHVLG	LRFN4	501	Q6PJG9
CRTHLGHLLNPGDLV	NMD3	361	Q96D46