Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessporphyrin-containing compound biosynthetic process

SLC25A39 SPTB ALAS1 PGRMC1

2.82e-0539934GO:0006779
GeneOntologyBiologicalProcesstetrapyrrole biosynthetic process

SLC25A39 SPTB ALAS1 PGRMC1

2.82e-0539934GO:0033014
GeneOntologyCellularComponentlaminin-3 complex

LAMA1 LAMA3

5.73e-053922GO:0005608
DomainLRR_6

FBXL13 TLR4 NLRC5 TLR9 LRRC74A

7.44e-0655925PF13516
DomainSpectrin_bsu

SPTB SPTBN1

1.43e-044922IPR016343
DomainTIR

IL1RAPL1 TLR4 TLR9

1.44e-0421923SM00255
DomainTIR

IL1RAPL1 TLR4 TLR9

1.66e-0422923PF01582
DomainSCAN

ZSCAN20 ZSCAN2 ZNF397 ZNF445

1.66e-0456924SM00431
Domain-

IL1RAPL1 TLR4 TLR9

1.91e-04239233.40.50.10140
DomainSCAN_BOX

ZSCAN20 ZSCAN2 ZNF397 ZNF445

1.91e-0458924PS50804
DomainSCAN

ZSCAN20 ZSCAN2 ZNF397 ZNF445

1.91e-0458924PF02023
DomainSCAN_dom

ZSCAN20 ZSCAN2 ZNF397 ZNF445

1.91e-0458924IPR003309
DomainRetrov_capsid_C

ZSCAN20 ZSCAN2 ZNF397 ZNF445

2.04e-0459924IPR008916
DomainTIR

IL1RAPL1 TLR4 TLR9

2.17e-0424923PS50104
DomainLaminin_aI

LAMA1 LAMA3

2.38e-045922IPR009254
DomainLaminin_I

LAMA1 LAMA3

2.38e-045922PF06008
DomainLaminin_II

LAMA1 LAMA3

2.38e-045922PF06009
DomainLaminin_domII

LAMA1 LAMA3

2.38e-045922IPR010307
DomainTIR_dom

IL1RAPL1 TLR4 TLR9

2.46e-0425923IPR000157
Domain-

ATP9B ATP9A ATP4A

5.17e-04329233.40.1110.10
Domain-

ATP9B ATP9A ATP4A

5.17e-04329232.70.150.10
DomainLAMININ_IVA

LAMA1 LAMA3

6.59e-048922PS51115
DomainLaminin_B

LAMA1 LAMA3

6.59e-048922PF00052
DomainLamB

LAMA1 LAMA3

6.59e-048922SM00281
DomainLaminin_IV

LAMA1 LAMA3

6.59e-048922IPR000034
DomainATPase_P-typ_cyto_domN

ATP9B ATP9A ATP4A

6.75e-0435923IPR023299
DomainP_typ_ATPase

ATP9B ATP9A ATP4A

7.34e-0436923IPR001757
DomainATPase_P-typ_P_site

ATP9B ATP9A ATP4A

7.34e-0436923IPR018303
DomainATPASE_E1_E2

ATP9B ATP9A ATP4A

7.34e-0436923PS00154
DomainLRR_1

LRIG3 FBXL13 TLR4 NLRC5 TLR9 LRRC74A

7.48e-04219926PF00560
DomainATPase_P-typ_transduc_dom_A

ATP9B ATP9A ATP4A

7.96e-0437923IPR008250
DomainE1-E2_ATPase

ATP9B ATP9A ATP4A

7.96e-0437923PF00122
DomainANX

ANXA1 ANXA11

1.81e-0313922SM00335
DomainANNEXIN

ANXA1 ANXA11

1.81e-0313922PS00223
DomainAnnexin_repeat_CS

ANXA1 ANXA11

1.81e-0313922IPR018252
DomainAnnexin

ANXA1 ANXA11

1.81e-0313922PF00191
DomainAnnexin_repeat

ANXA1 ANXA11

1.81e-0313922IPR018502
Domain-

ANXA1 ANXA11

1.81e-03139221.10.220.10
DomainSANT

BDP1 ZSCAN20 MYSM1

1.92e-0350923SM00717
DomainAnnexin

ANXA1 ANXA11

2.10e-0314922IPR001464
DomainIMPORTIN_B_NT

TNPO2 IPO11

2.10e-0314922PS50166
DomainP_typ_ATPase_c

ATP9B ATP9A

2.10e-0314922IPR032630
DomainP-type_ATPase_N

ATP9B ATP9A

2.10e-0314922IPR032631
DomainCyt-b5

PGRMC2 PGRMC1

2.10e-0314922PF00173
DomainCyt_B5-like_heme/steroid-bd

PGRMC2 PGRMC1

2.10e-0314922IPR001199
DomainP-type_ATPase_IV

ATP9B ATP9A

2.10e-0314922IPR006539
DomainCyt-b5

PGRMC2 PGRMC1

2.10e-0314922SM01117
DomainPhoLip_ATPase_C

ATP9B ATP9A

2.10e-0314922PF16212
DomainPhoLip_ATPase_N

ATP9B ATP9A

2.10e-0314922PF16209
Domain-

PGRMC2 PGRMC1

2.10e-03149223.10.120.10
DomainSANT/Myb

BDP1 ZSCAN20 MYSM1

2.15e-0352923IPR001005
DomainARM-like

RIF1 TNPO2 LTN1 PRKDC MN1 IPO11

2.18e-03270926IPR011989
DomainLeu-rich_rpt

LRIG3 FBXL13 TLR4 NLRC5 TLR9 LRRC74A

2.22e-03271926IPR001611
DomainIBN_N

TNPO2 IPO11

2.42e-0315922PF03810
DomainLaminin_N

LAMA1 LAMA3

2.75e-0316922IPR008211
DomainIBN_N

TNPO2 IPO11

2.75e-0316922SM00913
DomainLAMININ_NTER

LAMA1 LAMA3

2.75e-0316922PS51117
DomainLaminin_N

LAMA1 LAMA3

2.75e-0316922PF00055
DomainLamNT

LAMA1 LAMA3

2.75e-0316922SM00136
DomainHEAT

TNPO2 PRKDC IPO11

2.93e-0358923IPR000357
DomainImportin-beta_N

TNPO2 IPO11

3.11e-0317922IPR001494
DomainZF_DAG_PE_1

RASGRP4 KSR2 PLEKHM3

3.88e-0364923PS00479
DomainZF_DAG_PE_2

RASGRP4 KSR2 PLEKHM3

3.88e-0364923PS50081
DomainLeu-rich_rpt_Cys-con_subtyp

FBXL13 NLRC5

3.89e-0319922IPR006553
DomainLRR_CC

FBXL13 NLRC5

3.89e-0319922SM00367
DomainC1

RASGRP4 KSR2 PLEKHM3

4.05e-0365923SM00109
DomainPE/DAG-bd

RASGRP4 KSR2 PLEKHM3

4.23e-0366923IPR002219
DomainHEAT_REPEAT

TNPO2 PRKDC IPO11

4.99e-0370923PS50077
Pubmed

Sensing of commensal organisms by the intracellular sensor NOD1 mediates experimental pancreatitis.

TLR4 PRKDC TLR9

3.93e-07695322902233
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

PMS2P2 BDP1 PPP2R3A SERPINB6 TBC1D5 PPP1R12A SPTB KSR2 LAMA3 NLRC5 WDR27 MGLL ATP9B UBE3C GLIS1 PCM1

2.66e-061489951628611215
Pubmed

IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis.

TLR4 PRKDC TLR9

7.03e-061495323853597
Pubmed

The toll-like receptor pathway: a novel mechanism of infection-induced carcinogenesis of prostate epithelial cells.

TLR4 TLR9

7.38e-06295218092352
Pubmed

TLR-Stimulated Eosinophils Mediate Recruitment and Activation of NK Cells In Vivo.

TLR4 TLR9

7.38e-06295228426135
Pubmed

Acquisition of adult-like TLR4 and TLR9 responses during the first year of life.

TLR4 TLR9

7.38e-06295220442853
Pubmed

Assessment of TLR4 and TLR9 signaling and correlation with human papillomavirus status and histopathologic parameters in oral tongue squamous cell carcinoma.

TLR4 TLR9

7.38e-06295232173390
Pubmed

Increased expression of Toll-like receptors 4 and 9 in human lung cancer.

TLR4 TLR9

7.38e-06295218763053
Pubmed

Changes in myometrial expression of progesterone receptor membrane components 1 and 2 are associated with human parturition at term.

PGRMC2 PGRMC1

7.38e-06295225266650
Pubmed

Alveolar bone loss in relation to toll-like receptor 4 and 9 genotypes and Porphyromonas gingivalis carriage.

TLR4 TLR9

7.38e-06295227492306
Pubmed

Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy.

SMTNL1 PPP1R12A

7.38e-06295220634291
Pubmed

Helicobacter pylori regulates TLR4 and TLR9 during gastric carcinogenesis.

TLR4 TLR9

7.38e-06295225400780
Pubmed

Toll-like receptor gene polymorphisms are associated with susceptibility to Graves' ophthalmopathy in Taiwan males.

TLR4 TLR9

7.38e-06295221050493
Pubmed

TLR4 896A/G and TLR9 1174G/A polymorphisms are associated with the risk of infectious mononucleosis.

TLR4 TLR9

7.38e-06295232753695
Pubmed

Polymorphisms and haplotypes of TLR-4/9 associated with bacterial infection, gingival inflammation/recession and oral cancer.

TLR4 TLR9

7.38e-06295236563560
Pubmed

TLR4 and TLR9 polymorphism: Probable role in susceptibility among the population of Bihar for Indian visceral leishmaniasis.

TLR4 TLR9

7.38e-06295233910419
Pubmed

The role of progesterone receptor membrane component (PGRMC) in the endometrium.

PGRMC2 PGRMC1

7.38e-06295235526781
Pubmed

Polymorphisms and expression of TLR4 and 9 in malaria in two ethnic groups of Assam, northeast India.

TLR4 TLR9

7.38e-06295222948021
Pubmed

Influence of TLR4 and TLR9 polymorphisms and haplotypes on multiple hrHPV infections and HPV16 copy number in cervical cancer and cervicitis.

TLR4 TLR9

7.38e-06295234416273
Pubmed

Common polymorphisms of toll-like receptors 4 and 9 are associated with the clinical manifestation of malaria during pregnancy.

TLR4 TLR9

7.38e-06295216779724
Pubmed

TLR9 2848 GA heterozygotic status possibly predisposes fetuses and newborns to congenital infection with human cytomegalovirus.

TLR4 TLR9

7.38e-06295225844529
Pubmed

Signaling crosstalk during sequential TLR4 and TLR9 activation amplifies the inflammatory response of mouse macrophages.

TLR4 TLR9

7.38e-06295219923461
Pubmed

Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation.

TLR4 TLR9

7.38e-06295212356687
Pubmed

Immunohistochemical expression of TLR4 and TLR9 in various grades of oral epithelial dysplasia and squamous cell carcinoma, and their roles in tumor progression: a pilot study.

TLR4 TLR9

7.38e-06295223651260
Pubmed

Gene Polymorphisms of TLR4 and TLR9 and Haemophilus influenzae Meningitis in Angolan Children.

TLR4 TLR9

7.38e-06295232967147
Pubmed

Diverse Profiles of Toll-Like Receptors 2, 4, 7, and 9 mRNA in Peripheral Blood and Biopsy Specimens of Patients with Celiac Disease.

TLR4 TLR9

7.38e-06295230057921
Pubmed

The Impact of Circulating Mitochondrial DNA on Cardiomyocyte Apoptosis and Myocardial Injury After TLR4 Activation in Experimental Autoimmune Myocarditis.

TLR4 TLR9

7.38e-06295228618428
Pubmed

TLR4- and TLR9-dependent effects on cytokines, cell viability, and invasion in human bladder cancer cells.

TLR4 TLR9

7.38e-06295225499923
Pubmed

Interactions of surface-expressed TLR-4 and endosomal TLR-9 accelerate lupus progression in anti-dsDNA antibody transgenic mice.

TLR4 TLR9

7.38e-06295224719374
Pubmed

Differential cell reaction upon Toll-like receptor 4 and 9 activation in human alveolar and lung interstitial macrophages.

TLR4 TLR9

7.38e-06295220843333
Pubmed

Associations of toll-like receptor 4 and 2 gene polymorphisms with susceptibility to ankylosing spondylitis: A meta-analysis.

TLR4 TLR9

7.38e-06295233369094
Pubmed

TLR9 and MyD88 are crucial for the development of protective immunity to malaria.

TLR4 TLR9

7.38e-06295222516959
Pubmed

Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation.

TLR4 TLR9

7.38e-06295212515817
Pubmed

Classic and non-classic progesterone receptors are both expressed in human spermatozoa.

PGRMC2 PGRMC1

7.38e-06295215702432
Pubmed

Expression patterns of progesterone receptor membrane components 1 and 2 in endometria from women with and without endometriosis.

PGRMC2 PGRMC1

7.38e-06295223793472
Pubmed

Association of TLR4 and TLR9 gene polymorphisms and haplotypes with cervicitis susceptibility.

TLR4 TLR9

7.38e-06295231365550
Pubmed

Cigarette smoke increases TLR4 and TLR9 expression and induces cytokine production from CD8(+) T cells in chronic obstructive pulmonary disease.

TLR4 TLR9

7.38e-06295222070100
Pubmed

Study of disease-relevant polymorphisms in the TLR4 and TLR9 genes: a novel method applied to the analysis of the Portuguese population.

TLR4 TLR9

7.38e-06295217482427
Pubmed

Genetic variants of TLR4 and TLR9 are risk factors for chronic Helicobacter pylori infection in South Indian Tamils.

TLR4 TLR9

7.38e-06295227993530
Pubmed

Association of polymorphisms in Toll-like receptors 4 and 9 with risk of pulmonary tuberculosis: a meta-analysis.

TLR4 TLR9

7.38e-06295225889916
Pubmed

Toll-like receptor 9 deficiency impacts sensory and motor behaviors.

TLR4 TLR9

7.38e-06295223624295
Pubmed

[Association of Toll-like receptor gene with Crohn's disease in Koreans].

TLR4 TLR9

7.38e-06295220026892
Pubmed

Association of TLR4 and TLR9 polymorphisms and haplotypes with cervical cancer susceptibility.

TLR4 TLR9

7.38e-06295231278284
Pubmed

Critical role of TLR9 in acute graft-versus-host disease.

TLR4 TLR9

7.38e-06295218941203
Pubmed

Toll-like receptor gene variants associated with bacterial vaginosis among HIV-1 infected adolescents.

TLR4 TLR9

7.38e-06295223021866
Pubmed

The agonists of TLR4 and 9 are sufficient to activate memory B cells to differentiate into plasma cells in vitro but not in vivo.

TLR4 TLR9

7.38e-06295218641311
Pubmed

Association of TLR4 and TLR9 gene polymorphisms with cervical HR-HPV infection status in Chinese Han population.

TLR4 TLR9

7.38e-06295236915050
Pubmed

Polymorphisms in Toll-like receptors genes changes the host's immune response and is associated with cervical cancer.

TLR4 TLR9

7.38e-06295235158151
Pubmed

TLR9 and TLR4 are required for the development of autoimmunity and lupus nephritis in pristane nephropathy.

TLR4 TLR9

7.38e-06295220810248
Pubmed

Cloning and tissue expression of two putative steroid membrane receptors.

PGRMC2 PGRMC1

7.38e-0629529705155
Pubmed

TLR4 deficiency upregulates TLR9 expression and enhances irinotecan-related intestinal mucositis and late-onset diarrhoea.

TLR4 TLR9

7.38e-06295234216140
Pubmed

Association between TLR4 and TLR9 gene polymorphisms with development of pulmonary tuberculosis in Zahedan, southeastern Iran.

TLR4 TLR9

7.38e-06295223766695
Pubmed

TLR4 and TLR9 are induced in oral lichen planus.

TLR4 TLR9

7.38e-06295222672741
Pubmed

Association of TLR4 and TLR9 gene polymorphisms with the risk and progression of cervical lesions in HPV-infected women.

TLR4 TLR9

7.38e-06295237097031
Pubmed

Human amnion contains a novel laminin variant, laminin 7, which like laminin 6, covalently associates with laminin 5 to promote stable epithelial-stromal attachment.

LAMA1 LAMA3

7.38e-0629528601594
Pubmed

PGRMC2 is an intracellular haem chaperone critical for adipocyte function.

PGRMC2 PGRMC1

7.38e-06295231748741
Pubmed

TLR4 and TLR9 polymorphisms are not associated with either rheumatoid arthritis or systemic lupus erythematosus in Mexican patients.

TLR4 TLR9

7.38e-06295233939072
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

RIF1 GAPVD1 AFTPH SPTBN1 PLCB3 PRKDC PGRMC1 MN1 FAM53C ZNF768 PCM1

8.84e-06774951115302935
Pubmed

Conditional Ablation of Progesterone Receptor Membrane Component 2 Causes Female Premature Reproductive Senescence.

PGRMC2 PGRMC1

2.21e-05395228005395
Pubmed

A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix.

SPTB SPTBN1

2.21e-05395211294830
Pubmed

TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort.

TLR4 TLR9

2.21e-05395217914947
Pubmed

Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils.

TLR4 TLR9

2.21e-05395227505671
Pubmed

Expression of toll-like receptors on antigen-presenting cells in patients with falciparum malaria.

TLR4 TLR9

2.21e-05395217854755
Pubmed

Enhanced efficacy of therapeutic cancer vaccines produced by co-treatment with Mycobacterium tuberculosis heparin-binding hemagglutinin, a novel TLR4 agonist.

TLR4 TLR9

2.21e-05395221368092
Pubmed

[Toll-like receptor gene polymorphisms and susceptibility to inflammatory bowel disease in Chinese Han and Caucasian populations].

TLR4 TLR9

2.21e-05395220646633
Pubmed

Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria.

TLR4 TLR9

2.21e-05395216371473
Pubmed

Toll-like receptor signaling in anti-cancer immunity.

TLR4 TLR9

2.21e-05395212630564
Pubmed

Single-nucleotide polymorphisms in the Toll-like receptor pathway increase susceptibility to infections in severely injured trauma patients.

TLR4 TLR9

2.21e-05395223425749
Pubmed

Systemically administered ligands of Toll-like receptor 2, -4, and -9 induce distinct inflammatory responses in the murine lung.

TLR4 TLR9

2.21e-05395221547259
Pubmed

A pilot study on expression of toll like receptors (TLRs) in response to herpes simplex virus (HSV) infection in acute retinal pigment epithelial cells (ARPE) cells.

TLR4 TLR9

2.21e-05395225121361
Pubmed

Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia.

TLR4 TLR9

2.21e-05395219933834
Pubmed

A Novel Role for Progesterone Receptor Membrane Component 1 (PGRMC1): A Partner and Regulator of Ferrochelatase.

PGRMC2 PGRMC1

2.21e-05395227599036
Pubmed

Activation of enteroendocrine cells via TLRs induces hormone, chemokine, and defensin secretion.

TLR4 TLR9

2.21e-05395217371986
Pubmed

Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia.

TLR4 TLR9

2.21e-05395220804821
Pubmed

Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis.

TLR4 TLR9

2.21e-05395218275280
Pubmed

TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells.

TLR4 TLR9

2.21e-05395220526283
Pubmed

Polymorphisms in Toll-like receptor genes and susceptibility to infections in allogeneic stem cell transplantation.

TLR4 TLR9

2.21e-05395219539691
Pubmed

Toll-like receptor 2 regulates CXC chemokine production and neutrophil recruitment to the cornea in Onchocerca volvulus/Wolbachia-induced keratitis.

TLR4 TLR9

2.21e-05395217875630
Pubmed

Polymorphisms in Toll-like receptors 2, 4, and 9 are highly associated with hearing loss in survivors of bacterial meningitis.

TLR4 TLR9

2.21e-05395222662111
Pubmed

Impaired Surface Expression of HLA-DR, TLR2, TLR4, and TLR9 in Ex Vivo-In Vitro Stimulated Monocytes from Severely Injured Trauma Patients.

TLR4 TLR9

2.21e-05395228255201
Pubmed

PGRMC1/2 promotes luteal vascularization and maintains the primordial follicles of mice.

PGRMC2 PGRMC1

2.21e-05395230306772
Pubmed

Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia.

PRKDC TLR9

2.21e-05395226796361
Pubmed

Cathelicidin modulates synthesis of Toll-like Receptors (TLRs) 4 and 9 in colonic epithelium.

TLR4 TLR9

2.21e-05395228988039
Pubmed

Association between genetic variants of TLR2, TLR4, TLR9 and schizophrenia.

TLR4 TLR9

2.21e-05395237718198
Pubmed

Evaluation of the detection of Toll-like receptors (TLRs) in cancer development and progression in patients with colorectal cancer.

TLR4 TLR9

2.21e-05395229883450
Pubmed

Stimulation of allergen-loaded macrophages by TLR9-ligand potentiates IL-10-mediated suppression of allergic airway inflammation in mice.

TLR4 TLR9

2.21e-05395215538945
Pubmed

TLR9 cooperates with TLR4 to increase IL-12 release by murine dendritic cells.

TLR4 TLR9

2.21e-05395217599410
Pubmed

Genetic variation of TLR-4, TLR-9 and TIRAP genes in Iranian malaria patients.

TLR4 TLR9

2.21e-05395221457584
Pubmed

TLR9-IL-2 axis exacerbates allergic asthma by preventing IL-17A hyperproduction.

TLR4 TLR9

2.21e-05395233093516
Pubmed

Association of toll-like receptor gene polymorphisms and its interaction with HPV infection in determining the susceptibility of cervical cancer in Chinese Han population.

TLR4 TLR9

2.21e-05395228497211
Pubmed

Live Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis activate the inflammatory response through Toll-like receptors 2, 4, and 9 in species-specific patterns.

TLR4 TLR9

2.21e-05395216731773
Pubmed

Expressions of Toll-like receptors 3, 4, 7, and 9 in cervical lesions and their correlation with HPV16 infection in Uighur women.

TLR4 TLR9

2.21e-05395221527067
Pubmed

Quantitative defects in invariant NKT cells and TLR responses in patients with hyper-IgE syndrome.

TLR4 TLR9

2.21e-05395225796310
Pubmed

Macrophage Toll-like Receptor 9 Contributes to Chemotherapy-Induced Neuropathic Pain in Male Mice.

TLR4 TLR9

2.21e-05395231270160
Pubmed

Genetic alterations within TLR genes in development of Toxoplasma gondii infection among Polish pregnant women.

TLR4 TLR9

2.21e-05395228500897
Pubmed

Increased Expression of Toll-Like Receptors 4, 5, and 9 in Small Bowel Mucosa from Patients with Irritable Bowel Syndrome.

TLR4 TLR9

2.21e-05395228246611
Pubmed

Extracts of Larix Leptolepis effectively augments the generation of tumor antigen-specific cytotoxic T lymphocytes via activation of dendritic cells in TLR-2 and TLR-4-dependent manner.

TLR4 TLR9

2.21e-05395222677561
Pubmed

Influence of genetic variability in toll-like receptors (TLR 2, TLR 4, and TLR 9) on human immunodeficiency virus-1 disease progression.

TLR4 TLR9

2.21e-05395236926756
Pubmed

Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis.

TLR4 TLR9

2.21e-05395223855294
Pubmed

Analysis of TLR2, TLR4, and TLR9 single nucleotide polymorphisms in children with bacterial meningitis and their healthy family members.

TLR4 TLR9

2.21e-05395228487240
InteractionSPATA46 interactions

USP34 SPATA46 GAPVD1 CTPS2 MGLL

1.89e-0728955int:SPATA46
InteractionTNFSF13B interactions

USP34 LRIG3 TNPO2 TMEM131 PRKDC UBE3C IPO11

1.51e-06119957int:TNFSF13B
Cytoband3q22.1

PPP2R3A TOPBP1 PLXND1

9.29e-05429533q22.1
GeneFamilyMembrane associated progesterone receptor family

PGRMC2 PGRMC1

7.14e-0546321282
GeneFamilyEF-hand domain containing|Spectrins

SPTB SPTBN1

2.48e-0476321113
GeneFamilyCD molecules|Toll like receptors

TLR4 TLR9

5.28e-0410632948
GeneFamilyLaminin subunits

LAMA1 LAMA3

7.71e-0412632626
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF8 ZSCAN20 ZNF493 ZNF432 ZSCAN2 ZNF397 ZNF768 GLIS1 ZNF445

8.10e-0471863928
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

BDP1 ZSCAN20 MYSM1

8.34e-0453633532
GeneFamilyAnnexins|Endogenous ligands

ANXA1 ANXA11

9.09e-0413632404
GeneFamilyATPase phospholipid transporting

ATP9B ATP9A

1.22e-03156321210
GeneFamilyArmadillo repeat containing|Importins

TNPO2 IPO11

1.76e-0318632596
GeneFamilyAnkyrin repeat domain containing

TRANK1 GLS2 PPP1R12A ANKLE2

1.01e-02242634403
CoexpressionGSE32533_WT_VS_MIR17_KO_ACT_CD4_TCELL_UP

LRIG3 MGLL ATP9A PGRMC1 GLIS1 CDH13 NEDD4

8.49e-06200957M8469
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

USP34 RIF1 GAPVD1 PPP2R3A PPP1R12A LTN1 TOPBP1 MGLL TMEM131 ANKLE2 MN1 DOP1B NEDD4

1.29e-058569513M4500
ToppCell(4)_Endothelial_cells-(40)_EC-arterial|(4)_Endothelial_cells / Cell class and subclass of bone marrow stroma cells in homeostatis

NIBAN1 PPP2R3A ANXA1 SPTBN1 MGLL CDH13

3.13e-06190946ff774faf3f12759d11e50ed7d189288bb79e22e1
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ACSM3 CLCN5 ZNF432 MGLL PLEKHM3

2.48e-0516394563b0badaee3b2d827b1f4524510e3384d8f8fcde
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HHIP ZSCAN20 SCARA5 MGLL CDH13

2.71e-051669453b67064a5149e72f895344d938c64b8ff65247f5
ToppCelldroplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMA3 MGLL PLXND1 ATP9A CDH13

4.66e-05186945c116cc9f41971622264434ebe29d18e719b0ae19
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

USP34 TRANK1 PPP1R12A LTN1 TMEM131

4.66e-0518694503db813598b67b1e08f759758a1c2023396921fa
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP5 LAMA3 MGLL PLXND1 CDH13

4.66e-051869455302399825f213d105ac70b91366a4513b732838
ToppCelllymphoid-NK_cell-TNFRSF18+IL7R+_NK_cell|lymphoid / Lineage, cell class and subclass

SERPINB6 GBP5 PLXND1 ATP9A GLIS1

4.78e-0518794599dfa50f6325b0d66d23ee8dcaa6437e7161628a
ToppCellPBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

RASGRP4 SHMT1 ZSCAN2 PLCB3 PLXND1

5.03e-05189945a2f4f1dd5452f7efb7427919a0b90875cf2e1dc7
ToppCellPBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RASGRP4 SHMT1 ZSCAN2 PLCB3 PLXND1

5.03e-0518994554a45b0cb7dea01caf1cf0a2664c40e5779a0b61
ToppCellPBMC-Severe-cDC_12|Severe / Compartment, Disease Groups and Clusters

RIF1 ZSCAN20 RBL1 TOPBP1 PRKDC

5.16e-0519094584ee185939bdefb10705b621a70da27701eadcee
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SMTNL1 MGLL ALAS1 PLXND1 CDH13

5.16e-05190945d87b9e9ca863270a9c7f61674271a6440c97d1f4
ToppCellChildren_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)|Children_(3_yrs) / Lineage, Cell type, age group and donor

IL1RAPL1 SERPINB6 SPTBN1 CDH13 NEDD4

5.29e-05191945f229abf69a1217194f74b0502486907e07dba989
ToppCellControl-Stromal-SMC|Stromal / Disease state, Lineage and Cell class

NIBAN1 CHCHD10 PPP1R12A SPTB CDH13

5.29e-051919452da83c493e60ad0278848957645277d76737a188
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SMTNL1 MGLL ALAS1 PLXND1 CDH13

5.42e-05192945285a9d332a1e07b94f222d4b518dd56928b9e075
ToppCellhuman_hepatoblastoma-Endothelial_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

ANXA1 NLRC5 MGLL PLXND1 CDH13

5.42e-05192945e09f609fed033a25baacaf4a07bbbae1076da366
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SERPINB6 SPTBN1 PLXND1 CDH13 NEDD4

5.98e-05196945b8f89a50114932c08fc5daac4b549adfe9df8e66
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SERPINB6 SPTBN1 PLXND1 CDH13 NEDD4

5.98e-05196945145fcf73deba9638b391a1af6c39fa205dc9829f
ToppCell367C-Fibroblasts-Fibroblast-K_(Pericytes)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

NIBAN1 CHCHD10 PPP1R12A MGLL CDH13

5.98e-051969451d94cecd378a829dd8014fc086d7fca48c953a91
ToppCell367C-Fibroblasts-Fibroblast-K_(Pericytes)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

NIBAN1 CHCHD10 PPP1R12A MGLL CDH13

5.98e-05196945aacec48285bcb7ccf1b538187071885e3602cc49
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SERPINB6 SPTBN1 PLXND1 CDH13 NEDD4

5.98e-05196945d0ff1082898d2db47c88d2678466514e9e9193d3
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

HHIP PPP1R12A BCHE MGLL CDH13

6.27e-05198945637f11e292b90d86cdc0d0d828eb26f38289c25b
ToppCell3'-GW_trimst-1-SmallIntestine-Endothelial|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NIBAN1 ANXA1 SPTBN1 PLXND1 IPO11

6.27e-05198945ff8a9adc1302a4679ccdfe9ef95ef53e4c7a5391
ToppCell3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-cycling_EC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NIBAN1 ANXA1 TLR4 PLXND1 IPO11

6.27e-0519894537d6557833877fc2ff51fbeb589e3eb832dbef5f
ToppCellCOVID-19_Severe-Neu_4|COVID-19_Severe / 5 Neutrophil clusters in COVID-19 patients

SERPINB6 RBL1 ANXA1 TOPBP1 DOP1B

6.27e-05198945bfdddddef9f3f0eb6af013873dec4e06b7c78c58
ToppCellControl-Control-Lymphocyte-T/NK-CD4+_T_activated|Control / Disease, condition lineage and cell class

TRANK1 GBP5 SPTBN1 SHMT1 NLRC5

6.27e-05198945ee71543559836fd59adc0da877b2ca538cba60cb
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

BDP1 USP34 NLRC5 DTHD1 PCM1

6.42e-05199945f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellCOVID-19_Severe-Neu_4|World / 5 Neutrophil clusters in COVID-19 patients

SERPINB6 RBL1 ANXA1 TOPBP1 DOP1B

6.42e-051999450e327479bbda5a16643cf317d293a2918d619f87
ToppCellCalu_3|World / Cell line, Condition and Strain

SLC25A39 ANXA11 LAMA3 SMARCE1 ATP9A

6.58e-05200945a549aa08aeefe905653266dae3936094ff55f8e4
Diseasemastitis (biomarker_via_orthology)

TLR4 TLR9

9.20e-062902DOID:10690 (biomarker_via_orthology)
Diseasecoronary restenosis (biomarker_via_orthology)

NPY5R CDH13

2.75e-053902DOID:4247 (biomarker_via_orthology)
Diseasespinocerebellar ataxia type 5 (implicated_via_orthology)

SPTB SPTBN1

5.50e-054902DOID:0050882 (implicated_via_orthology)
Diseasepulmonary tuberculosis

RBL1 LAMA3 NEDD4

9.47e-0529903EFO_1000049
Diseasefamilial meningioma (is_implicated_in)

SMARCE1 MN1

1.37e-046902DOID:4586 (is_implicated_in)
DiseaseMENINGIOMA, FAMILIAL, SUSCEPTIBILITY TO

SMARCE1 MN1

1.37e-046902607174
DiseaseFamilial meningioma

SMARCE1 MN1

1.37e-046902cv:C3551915
Diseasemeningioma (is_implicated_in)

SMARCE1 MN1

1.37e-046902DOID:3565 (is_implicated_in)
DiseaseFamilial meningioma

SMARCE1 MN1

1.37e-046902C1333989
DiseaseMitral valve prolapse

SPTBN1 MN1 GLIS1

1.82e-0436903HP_0001634
Diseasecutaneous leishmaniasis (is_marker_for)

TLR4 TLR9

4.07e-0410902DOID:9111 (is_marker_for)
Diseasedry eye syndrome (is_marker_for)

ANXA1 TLR4

4.07e-0410902DOID:10140 (is_marker_for)
Diseaseallergic conjunctivitis (is_marker_for)

TLR4 TLR9

4.07e-0410902DOID:11204 (is_marker_for)
Diseasevelopharyngeal dysfunction

TBC1D5 PPP1R12A LAMA1 CHRNA3

5.40e-04122904EFO_0009336
DiseaseTinnitus

SCARA5 SPTBN1 TMEM131 CDH13

6.86e-04130904HP_0000360
DiseaseDNA methylation

SCARA5 WDR27 SMARCE1 ATP9A ANO3 GLIS1 CDH13 ZBBX

8.95e-04656908GO_0006306
Diseasechronic obstructive pulmonary disease (is_implicated_in)

HHIP TLR4 CHRNA3

9.55e-0463903DOID:3083 (is_implicated_in)
DiseaseAlcohol abuse

NPY5R TLR4 CHRNA3

1.14e-0367903C0085762
Diseaseallergic rhinitis (is_marker_for)

TLR4 TLR9

1.21e-0317902DOID:4481 (is_marker_for)
Diseasedermatomyositis (is_marker_for)

TLR4 TLR9

1.21e-0317902DOID:10223 (is_marker_for)
Diseaseperinatal necrotizing enterocolitis (biomarker_via_orthology)

TLR4 TLR9

1.21e-0317902DOID:8677 (biomarker_via_orthology)
Diseasesinusitis (is_marker_for)

TLR4 TLR9

1.36e-0318902DOID:0050127 (is_marker_for)
Diseasesquamous cell carcinoma (is_marker_for)

ANXA1 TLR9

1.52e-0319902DOID:1749 (is_marker_for)
Diseasepars triangularis volume measurement

SPTBN1 MGLL

1.69e-0320902EFO_0010321
Diseaseuveitis (biomarker_via_orthology)

ANXA1 TLR4

2.64e-0325902DOID:13141 (biomarker_via_orthology)
Diseaseanogenital venereal wart (is_marker_for)

TLR4 TLR9

2.85e-0326902DOID:11168 (is_marker_for)
Diseaseblood rubidium measurement

RIF1 CDH13

2.85e-0326902EFO_0021529
Diseaseacute necrotizing pancreatitis (biomarker_via_orthology)

TLR4 TLR9

2.85e-0326902DOID:0080998 (biomarker_via_orthology)
Diseasevenous thromboembolism

SERPINB6 TBC1D5 TLR4 MGLL CCDC181 IPO11

2.87e-03460906EFO_0004286

Protein segments in the cluster

PeptideGeneStartEntry
GFLSLICSKNSLESD

BDP1

2506

A6H8Y1
FSNDRLKDGLCLSES

ANKLE2

276

Q86XL3
TLNLAKLTGCSRENE

BCHE

271

P06276
LQLEREGKGLSQSCS

CCDC116

201

Q8IYX3
RLGTDESKFNAVLCS

ANXA11

371

P50995
ELSNLNCFSRAESKG

CHRNA3

376

P32297
NLSEECQLARKSSGT

AFTPH

506

Q6ULP2
EDQSILNLTFSDCKG

CDH13

46

P55290
NKNDSVLRCSFADLS

ANO3

86

Q9BYT9
ESSSLCRFDGNTLKT

NUDCD1

416

Q96RS6
FNSCLQTKSIDDGEL

LTN1

1171

O94822
DTSGDFRNALLSLAK

ANXA1

171

P04083
NSLKRDVSLGGCSLN

LAMA3

2916

Q16787
LSNSCKTRDDFLGQV

NEDD4

511

P46934
RSSENLSLDDCNKNL

MAP7D2

701

Q96T17
FLLLQGSADRLCDSK

MGLL

231

Q99685
NQRGSSVFCKASLEL

ALAS1

116

P13196
ADCAFRGLSSLKTLD

LRIG3

351

Q6UXM1
SEKAGSCFIRTDQLD

ATP9B

256

O43861
CRDALGSDLKLSYTQ

DOP1B

396

Q9Y3R5
LKQFLECSRSIGTDN

IPO11

246

Q9UI26
SNLEGLRTKCATSND

KSR2

36

Q6VAB6
KTLRFSLCSDNLEGI

GAPVD1

561

Q14C86
CKELFASALSNDLLQ

PCM1

171

Q15154
AFIDACSISDLQLGK

PLXND1

1801

Q9Y4D7
ETQLGDSANLTCRAF

IL1RAPL1

256

Q9NZN1
ASRGLATFCLDKEAL

PGRMC1

121

O00264
ASRGLATFCLDKDAL

PGRMC2

151

O15173
LLEKCIQSFDSAGSL

RASGRP4

61

Q8TDF6
DFKEDSAALLCQALS

LRRC74A

201

Q0VAA2
GSKQQLSRDSLLSGC

POLG2

81

Q9UHN1
RNLEASSDYCSALLK

GBP5

396

Q96PP8
GLLDRDLFRKCVSSN

GLS2

126

Q9UI32
LRTSEKNGSCFLRTD

ATP9A

176

O75110
KNGSCFLRTDQLDGE

ATP9A

181

O75110
KLACGNTSVSEDFLL

OR13J1

186

Q8NGT2
LSLERGLTAQSFKCA

PLEKHM3

501

Q6ZWE6
FAQELVECKSSRGSL

PPP2R3A

601

Q06190
EDQAGKTLRLSECSF

NLRC5

1321

Q86WI3
VETALESCGLKFNRS

PLCB3

186

Q01970
LLSLTNGSCEENKDR

CCDC181

201

Q5TID7
STCDEARGALKNLLF

FAM189B

161

P81408
QSDLSLCEGFSEALK

CHCHD10

116

Q8WYQ3
CTDQLATRIKFLTDG

DHX35

141

Q9H5Z1
SELFNDCGLLDSSKL

CLCN5

456

P51795
RITDDGIQAFCKSSL

FBXL13

566

Q8NEE6
ASECLKLLGFRSQDS

DTHD1

436

Q6ZMT9
EGSLQLEACRKASFL

GLIS1

131

Q8NBF1
SSCKQDDLLSGDLIF

GJB5

236

O95377
LSKRTLCQRDFGDLD

FAM53C

371

Q9NYF3
EDSFDGRSLSKLNLC

SCARA5

21

Q6ZMJ2
LTLCNRAAFKSGQDA

ATP4A

436

P20648
KDNLFGQSCLAALST

MN1

816

Q10571
FASRAVLEALGSCLN

SHMT1

56

P34896
LDFSTSGALCVALNK

RPUSD1

66

Q9UJJ7
ESTDSFNNELKRLCG

SMARCE1

261

Q969G3
GECLLDLSSFTDNSK

RBL1

286

P28749
RDSFDNCSLGESSKI

RIF1

1686

Q5UIP0
RSISCGLSNKENRLE

NPY5R

236

Q15761
FQGKALSSLCALSDV

PMS2P2

171

O95744
GCIKNLEISRSTFDL

LAMA1

2456

P25391
ANRLFGEKSCDFLSS

SERPINB6

91

P35237
LCSDSNGKNRSSARI

HHIP

451

Q96QV1
SSASNLGFRCAADRL

SUMF1

356

Q8NBK3
DARNDSFTTCIELGK

SPTBN1

1961

Q01082
GSLSRKFANILSEAC

ACSM3

101

Q53FZ2
DNSFLSSKVLELCGD

CNMD

181

O75829
RNCLNLKDADSTEFR

CTPS2

411

Q9NRF8
RDCGKSFSRSANLIT

ZSCAN2

281

Q7Z7L9
LECGKNFSDRSNLNT

ZSCAN20

741

P17040
AADQKRFSALLSDCV

NIBAN1

181

Q9BZQ8
EQKARLGDRLSSGSC

SPATA46

226

Q5T0L3
LAFSTAEKLADCAQL

SMTNL1

441

A8MU46
DQLKAFLCGRALTSD

SLC25A39

146

Q9BZJ4
CSTSLRALDFSGNAL

TLR9

596

Q9NR96
RQSSFALLGDLTKAC

TNPO2

681

O14787
LNAFTRKADAVLGCS

SOGA1

486

O94964
EVFSKLGLSRSCNQA

TMEM131

1736

Q92545
DDCGKAFSQSSDLIR

ZNF768

516

Q9H5H4
SKNFSACLELGESLL

SPTB

1956

P11277
SCKQLASGLLELAFA

PRKDC

1506

P78527
KEACSQSSRLTGLQD

ZNF445

956

P59923
SECGKAFSLSSNLIR

ZNF397

456

Q8NF99
TLGKDRECQSQSLAL

ZNF8

136

P17098
GNTASQTKSLCLFRE

ZNF432

111

O94892
EECGKAFNRSSILSI

ZNF493

476

Q6ZR52
CTDRGNSDDFILISK

TBC1D5

706

Q92609
SSCGTDLRNRKLESQ

USP34

636

Q70CQ2
KDFQSLSILLAGSCA

WDR27

346

A2RRH5
RLTADKDFQASCLLG

TRANK1

1936

O15050
EFLDLSRNGLSFKGC

TLR4

376

O00206
CAGAEKESLTFLANL

TOPBP1

656

Q92547
GKRDFLNLCLRNSST

ZBBX

451

A8MT70
SLFVKQLDGSERLTC

UBE3C

126

Q15386
DLSIRGFNKETAAAC

TSN

211

Q15631
CDGEIKTFSDLQSLR

L1TD1

286

Q5T7N2
KSCSFGRRQDDLISS

PPP1R12A

551

O14974
DSQEALFSKSSRGCL

MYSM1

266

Q5VVJ2