Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionadrenergic receptor binding

APLP1 BDKRB2

2.09e-0424182GO:0031690
DomainIRF1/IRF2

IRF1 IRF2

9.80e-072192IPR017431
DomainIRF

IRF1 IRF2

3.51e-059192SM00348
DomainInterferon_reg_fac_CS

IRF1 IRF2

3.51e-059192IPR019817
DomainIRF_2

IRF1 IRF2

3.51e-059192PS51507
DomainInterferon_reg_fact_DNA-bd_dom

IRF1 IRF2

3.51e-059192IPR001346
DomainIRF

IRF1 IRF2

3.51e-059192PF00605
DomainIRF_1

IRF1 IRF2

3.51e-059192PS00601
Domain-

IRF1 IRF2 DEPDC5

1.32e-032181931.10.10.10
DomainWHTH_DNA-bd_dom

IRF1 IRF2 DEPDC5

1.79e-03242193IPR011991
Domain-

POMGNT1 CSGALNACT1

3.03e-03811923.90.550.10
DomainNucleotide-diphossugar_trans

POMGNT1 CSGALNACT1

3.56e-0388192IPR029044
DomainTPR-contain_dom

ZC3H7A TTC13

1.00e-02150192IPR013026
DomainTPR

ZC3H7A TTC13

1.20e-02165192PS50005
DomainTPR_REGION

ZC3H7A TTC13

1.20e-02165192PS50293
Domain-

ZC3H7A TTC13

1.85e-022071921.25.40.10
DomainTPR-like_helical_dom

ZC3H7A TTC13

2.30e-02233192IPR011990
PathwayBIOCARTA_PCAF_PATHWAY

IRF1 IRF2

7.10e-0513142M22007
PathwayREACTOME_PYROPTOSIS

IRF1 IRF2

3.17e-0427142M41804
PathwayWP_TYPE_II_INTERFERON_SIGNALING_IFNG

IRF1 IRF2

4.19e-0431142MM15958
PathwayWP_TYPE_II_INTERFERON_SIGNALING

IRF1 IRF2

5.98e-0437142M39363
PathwayREACTOME_PYRUVATE_METABOLISM

MPC1L MAEA

1.05e-0349142M17157
PathwayREACTOME_REGULATED_NECROSIS

IRF1 IRF2

1.52e-0359142M41803
PathwayREACTOME_AEROBIC_RESPIRATION_AND_RESPIRATORY_ELECTRON_TRANSPORT

MPC1L MAEA OXA1L

1.94e-03260143M516
Pubmed

Interferon regulatory factor 1 inactivation in human cancer.

IRF1 IRF2

3.14e-07220229599126
Pubmed

A genome-wide screen identifies IRF2 as a key regulator of caspase-4 in human cells.

IRF1 IRF2

3.14e-07220231353801
Pubmed

Interferon regulatory factor (IRF)-1 and IRF-2 regulate interferon gamma-dependent cyclooxygenase 2 expression.

IRF1 IRF2

3.14e-07220210859338
Pubmed

Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development.

IRF1 IRF2

3.14e-0722028402903
Pubmed

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes.

IRF1 IRF2

3.14e-0722022475256
Pubmed

Repression of IFN-gamma induction of class II transactivator: a role for PRDM1/Blimp-1 in regulation of cytokine signaling.

IRF1 IRF2

3.14e-07220216982896
Pubmed

Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system.

IRF1 IRF2

3.14e-0722027507207
Pubmed

Differential dysregulation of nitric oxide production in macrophages with targeted disruptions in IFN regulatory factor-1 and -2 genes.

IRF1 IRF2

3.14e-0722028617930
Pubmed

The roles of interferon regulatory factors 1 and 2 in the progression of human pancreatic cancer.

IRF1 IRF2

3.14e-07220224632547
Pubmed

The role of interferon regulatory factors in the interferon system and cell growth control.

IRF1 IRF2

3.14e-0722029865486
Pubmed

Deficiency in the transcription factor interferon regulatory factor (IRF)-2 leads to severely compromised development of natural killer and T helper type 1 cells.

IRF1 IRF2

3.14e-07220210934221
Pubmed

Mesenchymal stem cells (MSCs) from the mouse bone marrow show differential expression of interferon regulatory factors IRF-1 and IRF-2.

IRF1 IRF2

3.14e-07220238194130
Pubmed

IL-12 is dysregulated in macrophages from IRF-1 and IRF-2 knockout mice.

IRF1 IRF2

9.42e-07320210415056
Pubmed

Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells.

IRF1 IRF2

9.42e-07320215226432
Pubmed

The growth-dependent expression of angiotensin II type 2 receptor is regulated by transcription factors interferon regulatory factor-1 and -2.

IRF1 IRF2

9.42e-0732027650042
Pubmed

B lymphocyte-induced maturation protein (Blimp)-1, IFN regulatory factor (IRF)-1, and IRF-2 can bind to the same regulatory sites.

IRF1 IRF2

9.42e-07320215494505
Pubmed

The role of the interferon regulatory factors, IRF-1 and IRF-2, in LPS-induced cyclooxygenase-2 (COX-2) expression in vivo and in vitro.

IRF1 IRF2

9.42e-07320212537697
Pubmed

TRIM14 expression is regulated by IRF-1 and IRF-2.

IRF1 IRF2

9.42e-07320231150153
Pubmed

Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors.

IRF1 IRF2

9.42e-0732027768900
Pubmed

Interferon regulatory factors: the next generation.

IRF1 IRF2

9.42e-07320210524230
Pubmed

Transcriptional regulation of the 230-kDa bullous pemphigoid antigen gene expression by interferon regulatory factor 1 and interferon regulatory factor 2 in normal human epidermal keratinocytes.

IRF1 IRF2

9.42e-07320215560761
Pubmed

Interferon regulatory factor 1 (IRF-1) and IRF-2 regulate PD-L1 expression in hepatocellular carcinoma (HCC) cells.

IRF1 IRF2

9.42e-07320232377817
Pubmed

Amino acid deprivation links BLIMP-1 to the immunomodulatory enzyme indoleamine 2,3-dioxygenase.

IRF1 IRF2

1.88e-06420219828629
Pubmed

IFN regulatory factor-2 cooperates with STAT1 to regulate transporter associated with antigen processing-1 promoter activity.

IRF1 IRF2

1.88e-06420215778351
Pubmed

Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy.

IRF1 IRF2

1.88e-06420212960317
Pubmed

UBE3A regulates the transcription of IRF, an antiviral immunity.

IRF1 IRF2

1.88e-06420230690483
Pubmed

The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness.

IRF1 IRF2

1.88e-06420210022868
Pubmed

Apolipoprotein L1 is transcriptionally regulated by SP1, IRF1 and IRF2 in hepatoma cells.

IRF1 IRF2

1.88e-06420232671843
Pubmed

Differential expression of interferon regulatory factor 1 (IRF-1), IRF-2, and interferon consensus sequence binding protein genes in lipopolysaccharide (LPS)-responsive and LPS-hyporesponsive macrophages.

IRF1 IRF2

1.88e-0642027822029
Pubmed

Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment.

IRF1 IRF2

1.88e-06420211304541
Pubmed

IFN-gamma represses IL-4 expression via IRF-1 and IRF-2.

IRF1 IRF2

1.88e-06420212479817
Pubmed

An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes.

IRF1 IRF2

1.88e-0642022111015
Pubmed

Possible involvement of the transcription factor ISGF3 gamma in virus-induced expression of the IFN-beta gene.

IRF1 IRF2

1.88e-0642027843405
Pubmed

Interferon regulatory transcription factors are constitutively expressed and spatially regulated in the mouse lens.

IRF1 IRF2

3.14e-06520210364426
Pubmed

Identification of novel co-repressor molecules for Interferon Regulatory Factor-2.

IRF1 IRF2

3.14e-06520212799427
Pubmed

Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth.

IRF1 IRF2

3.14e-0652029865487
Pubmed

Ubc9-mediated sumoylation leads to transcriptional repression of IRF-1.

IRF1 IRF2

3.14e-06520218955028
Pubmed

Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription.

IRF1 IRF2

4.71e-06620222042864
Pubmed

HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections.

IRF1 IRF2

4.71e-06620228970238
Pubmed

Susceptibility of IFN regulatory factor-1 and IFN consensus sequence binding protein-deficient mice to brucellosis.

IRF1 IRF2

4.71e-06620211859135
Pubmed

Hepatitis B viraemia: its heritability and association with common genetic variation in the interferon gamma signalling pathway.

IRF1 IRF2

1.41e-051020220980339
Pubmed

Differential constitutive expression of interferon genes in early mouse embryos.

IRF1 IRF2

2.85e-05142027654369
Pubmed

Cytokine gene regulation: regulatory cis-elements and DNA binding factors involved in the interferon system.

IRF1 IRF2

2.85e-05142021442307
Pubmed

Short Communication: Expression of APOBEC3G and Interferon Gamma in Pleural Fluid Mononuclear Cells from HIV/TB Dual Infected Subjects.

IRF1 IRF2

3.75e-051620225924204
Pubmed

Bacterial ligand of TLR2 signals Stat activation via induction of IRF1/2 and interferon-alpha production.

IRF1 IRF2

3.75e-051620218652890
Pubmed

A diverse range of gene products are effectors of the type I interferon antiviral response.

IRF1 IRF2

4.25e-051720221478870
Pubmed

The role of Irf6 in tooth epithelial invagination.

IRF1 IRF2

7.21e-052220222366192
Pubmed

Beads-free protein immunoprecipitation for a mass spectrometry-based interactome and posttranslational modifications analysis.

PRPF8 OPA3 RPL19

1.27e-0417220326336360
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

PRPF8 PASK TTC13 MAEA RPL19

1.86e-0497420528675297
Pubmed

A systems wide mass spectrometric based linear motif screen to identify dominant in-vivo interacting proteins for the ubiquitin ligase MDM2.

IRF1 IRF2

2.07e-043720224583282
Pubmed

A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation.

IRF1 IRF2

5.63e-046120232911434
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

ZC3H7A TTC13

1.10e-0311582769
CoexpressionGSE3982_MAC_VS_CENT_MEMORY_CD4_TCELL_DN

PASK IRF2 CSGALNACT1 MAEA

1.12e-05198194M5507
CoexpressionGSE11924_TFH_VS_TH2_CD4_TCELL_UP

ZC3H7A OPA3 DEPDC5 MAEA

1.17e-05200194M3153
CoexpressionISHIKAWA_STING_SIGNALING

IRF1 IRF2

2.23e-0510192M7982
CoexpressionSOBOLEV_PBMC_PANDEMRIX_AGE_18_64YO_1DY_UP

IRF1 IRF2

1.04e-0421192M41167
CoexpressionSCHERER_PBMC_APSV_WETVAX_AGE_18_40YO_5_TO_7DY_UP

IRF1 IRF2

1.36e-0424192M41045
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4-Teffector/EM_CD4|GI_small-bowel / Manually curated celltypes from each tissue

PASK CSGALNACT1 RPL19

5.27e-05165203ecaeb90a6bc27524ef6f2eefa72aec7315dbde3b
ToppCellfacs-Heart-RA-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APLP1 MPC1L KLHL23

8.02e-05190203bfbdf16d488359d7935a419c4c1823288f39c183
ToppCellfacs-Heart-RA-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APLP1 MPC1L KLHL23

8.02e-05190203eb1f8bb4d903b08e50c2dc173b06c0c79d8e316e
ToppCellmetastatic_Brain-T/NK_cells-Naive_CD4+_T|metastatic_Brain / Location, Cell class and cell subclass

PASK IRF1 RPL19

8.14e-051912034613eae77e2fbb1c526582de46ffed6bda61ea6b
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-Tnaive/CM_CD4|GI_small-bowel / Manually curated celltypes from each tissue

PASK CSGALNACT1 RPL19

8.40e-05193203772e0370bda4bffed7798b8714e32c9e2a1d9b67
ToppCellControl-Lymphocyte-T_NK-CD4_Naive|Control / Disease, Lineage and Cell Type

PASK CSGALNACT1 RPL19

8.40e-05193203643ee12ab81d4f6c97633872f4123b90a1846d50
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T_naive|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PASK CSGALNACT1 RPL19

8.53e-05194203e0ccf18edbae09fc1068f1e923f1bc0d0ff44195
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T_naive-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PASK CSGALNACT1 RPL19

8.53e-051942032e2019a7bf57f257f0ff9b24eacff59dbb952ebb
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T_naive-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PASK CSGALNACT1 RPL19

8.53e-05194203fc0504730ae576ff46ba0bc9f585c53ab78d914c
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T_naive|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

PASK CSGALNACT1 RPL19

8.53e-05194203d788d5bd1e651706e7e2d54ada546a5e84f86ff0
ToppCellControl-Lymphoid_T/NK-CD4+_T_naive|Control / Disease group, lineage and cell class

PASK CSGALNACT1 RPL19

8.53e-05194203aabcd9f71d8ef54add5c46d8a3e226e3ae3ab124
ToppCellCD8+_Memory_T_cell-CV-5|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

PASK OXA1L RPL19

8.53e-051942035d644fe6da99b023eee100882ee7b71af4f3814a
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PASK CSGALNACT1 RPL19

8.66e-05195203497d4bfbc38bcafab37e8a9c20bc9141f2e78d2a
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c05-FOS|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PASK CSGALNACT1 RPL19

8.66e-051952039c71d2a58e772b556e22e2f1d60593580b7aafd8
ToppCellILEUM-inflamed-(1)_T_cell-(1)_Naive_T_cells|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PASK CSGALNACT1 RPL19

8.66e-05195203c82d312ddc3231b0f3c58b2fb74af5dad24948e4
ToppCellILEUM-non-inflamed-(1)_T_cell-(1)_Naive_T_cells|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PASK CSGALNACT1 RPL19

8.79e-05196203eda187f50e1bcf8f9bc9af3ea05c63748d66570a
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PASK CSGALNACT1 RPL19

8.92e-05197203442fb5ee17e6d4d8c280721b21fd3f7ba6475951
ToppCellTransverse-T_cell-Tcm|T_cell / Region, Cell class and subclass

PASK CSGALNACT1 RPL19

9.06e-0519820362990b9ff7ca20895fed07461baba6c2caaa995e
ToppCellCaecum-T_cell-Tcm|Caecum / Region, Cell class and subclass

PASK CSGALNACT1 RPL19

9.19e-05199203cab97db995a7d7df3b8f0511139ef0fe65ee55b9
ToppCellCaecum-(1)_T_cell-(14)_Tcm|Caecum / shred on region, Cell_type, and subtype

PASK CSGALNACT1 RPL19

9.19e-051992030f89426e8dec0cbe78f6c55caaa196daf0eaf66a
ToppCellSigmoid-T_cell-Tcm|T_cell / Region, Cell class and subclass

PASK APLP1 CSGALNACT1

9.19e-05199203acdf95f4d58df47690f4ae254245bc618f9ac07e
ToppCellCaecum-T_cell-Activated_CD4_T|T_cell / Region, Cell class and subclass

PASK CSGALNACT1 RPL19

9.19e-0519920313173cc4dcc8e856680372b0a4ad4f36afa892c1
ToppCellVE-CD4-antiviral_CD4|VE / Condition, Cell_class and T cell subcluster

PASK IRF1 RPL19

9.19e-05199203056a0538ca5e825ae6195b4c76c208708a014533
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-CD8_EM|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PASK IRF1 RPL19

9.33e-05200203712e3b7c12308b547cfe362b46a6313236391667
ToppCellControl-Control-Lymphocyte-T/NK-CD4+_T_naive|Control / Disease, condition lineage and cell class

PASK CSGALNACT1 RPL19

9.33e-0520020359b446cd886767f19553aed779ab313685789f6f
ToppCellTransverse-T_cell-Activated_CD4_T|T_cell / Region, Cell class and subclass

PASK CSGALNACT1 RPL19

9.33e-05200203d89d3c16406d77cb08e1aa00d7df6887a692c337
ToppCell(14)_Tcm|World / shred on Cell_type and subtype

PASK CSGALNACT1 RPL19

1.03e-042072035521742c28b99d5e3119da11bd56a33bd4243bb3
ToppCellileum-Epithelial_Stem_Cells|ileum / shred on tissue and cell subclass

PASK CSGALNACT1

1.43e-03126202a8ed48cbd1e207fd1aaad454fda9f329eb22aa83
ToppCell343B-Lymphocytic-NK_cells-NK_cell_A2|343B / Donor, Lineage, Cell class and subclass (all cells)

CSGALNACT1 TTC13

1.59e-031332028ff1cf0ea1fc33fe8384c0e65c1ee1853b25a2ae
ToppCellPND01-03-samps-Mesenchymal-Pericyte-pericyte_E|PND01-03-samps / Age Group, Lineage, Cell class and subclass

MPC1L KLHL23

1.64e-0313520235928195cf34f055b353562c96f451aef2344d64
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CSGALNACT1 DEPDC5

1.71e-03138202a88c3ae56b0af60f6e87cabade4f21e2bbb336f2
ToppCellBac-SEP-Lymphocyte-T_NK-CD8_Naive|Bac-SEP / Disease, Lineage and Cell Type

PASK RPL19

1.86e-03144202fdcf84e8b5fdc0730f243919f9cc30492e24dd75
ToppCell343B-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

PASK RPL19

1.94e-03147202d655e6ede8bca65a62efada2b15c7916e5f19324
ToppCellTCGA-Uterus-Primary_Tumor-Uterine_Carcinoma-Uterine_Carcinosarcoma|TCGA-Uterus / Sample_Type by Project: Shred V9

CSGALNACT1 TTC13

2.04e-031512022810bfa01bd3016aeba29735eb4a9284792e8aac
ToppCellPND01-03-samps-Mesenchymal-Pericyte|PND01-03-samps / Age Group, Lineage, Cell class and subclass

MPC1L KLHL23

2.07e-03152202fc9472bc19f997103da535b035105f01429cb08e
ToppCellMS-CD4-antiviral_CD4|MS / Condition, Cell_class and T cell subcluster

PASK IRF1

2.07e-03152202b1eba2d5a6da3eeb83d40a92976e3e8751ed18ee
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-lymphocytic-T_lymphocytic-naive_thymus-derived_CD4-positive,_alpha-beta_T_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PASK RPL19

2.12e-03154202561d4d0481e47cf0dc86b09fba2b8f2b128377c9
ToppCellICU-SEP-Lymphocyte-T_NK-CD8_TCM|ICU-SEP / Disease, Lineage and Cell Type

PASK RPL19

2.21e-031572028ff52e532b149887c18f76b151325281821692b5
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PASK TRPM1

2.26e-031592028d958d79f5eb3ab683d1245ae7f4f22a2cefbc55
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-T_lymphocytic-naive_thymus-derived_CD4-positive,_alpha-beta_T_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PASK RPL19

2.29e-031602026b5b5aa12f0d00757728f5597f569d68406d6f56
ToppCellfacs-Thymus-Thymus_Flowthrough-18m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IRF1 IRF2

2.35e-031622027e6d20704d77b28512690f882f9ddbbd9c5c3228
ToppCellfacs-Thymus-Thymus_Flowthrough|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IRF1 IRF2

2.35e-031622022c193f766f2cefe67682f34325d1de6aed778f49
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD8-Tem/emra_CD8|GI_small-bowel / Manually curated celltypes from each tissue

CSGALNACT1 RPL19

2.37e-031632021a8c79903ed416f286ebe8a9922233affbc55d82
ToppCellIonocyte|World / shred by cell class for turbinate

CSGALNACT1 KLHL23

2.43e-031652020cb2199b87f17ece743fb2652b2f448dfa78ae0b
ToppCellBAL-Severe-cDC_2|Severe / Compartment, Disease Groups and Clusters

PASK CSGALNACT1

2.46e-03166202602a72a607534d5f21eddd2c7a52a57084f4920f
ToppCellICU-NoSEP-Lymphocyte-T_NK-MAIT|ICU-NoSEP / Disease, Lineage and Cell Type

POMGNT1 OPA3

2.46e-03166202d3fa2e42497201f1ca57f4f977fbaa0def950033
ToppCell10x5'-Liver-Lymphocytic_T_CD4-Tnaive/CM_CD4|Liver / Manually curated celltypes from each tissue

PASK RPL19

2.49e-03167202ab6273ae5d76a3f9a05c58320e3dee80f9b99e47
ToppCelldroplet-Marrow-BM-1m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PASK TRPM1

2.52e-031682022e88d9cb7c80a4656fab290db8b45a5a0599d769
ToppCellLV-05._Cytoplasmic_Cardiomyocyte_I|LV / Chamber and Cluster_Paper

RPL19 SPRYD3

2.52e-031682021732c9e8cdae99525148f7ee09f6302b16f0a724
ToppCellHealthy_donor-CD8+_T_naive|Healthy_donor / disease group, cell group and cell class (v2)

PASK RPL19

2.55e-0316920266216758e581365f10c2a66714d83a606ad23af0
ToppCellnormal_Pleural_Fluid-Myeloid_cells-CD163+CD14+_DCs|Myeloid_cells / Location, Cell class and cell subclass

PASK CSGALNACT1

2.55e-03169202bea8aba1f3cc3d0e8d448c1c45f5354d26ebf850
ToppCellInt-URO-Lymphocyte-T_NK-CD4_Naive|Int-URO / Disease, Lineage and Cell Type

PASK RPL19

2.58e-03170202577915dd1f5c418b9b98a7a7153e2b5d1b93ca84
ToppCellILEUM-non-inflamed-(1)_T_cell-(1)_Central_Memory_T_cells|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PASK RPL19

2.58e-03170202d4c95c317a731c0db2c213c64cb87da636d30f00
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-SELL+_CD8_T|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PASK RPL19

2.61e-031712028652b328e7f828c74fd28ac7e40ac7741cde3730
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l4|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

APLP1 RPL19

2.67e-0317320242272af45547422ef85e35f4a4c7d269e9ed7a8a
ToppCellcontrol-Lymphocytic-CD4_T_cells_3|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

APLP1 CSGALNACT1

2.67e-031732020c9fb18536ddd61b51b7bb4d40841f67b017f360
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l9|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

APLP1 RPL19

2.67e-0317320215a77f6aac968b7a1afea4f60aedbb95b9d0f765
ToppCell10x5'-blood-Lymphocytic_T_CD8-Tnaive/CM_CD8|blood / Manually curated celltypes from each tissue

PASK RPL19

2.70e-031742028273de40552d1cca1a8fe3647fd5e4cb4bb70f99
ToppCell10x5'-Liver-Lymphocytic_T_CD8-Tnaive/CM_CD8|Liver / Manually curated celltypes from each tissue

PASK RPL19

2.70e-0317420203918ca51ae3b4c9c1a74769b08ea23f518286ba
ToppCell367C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PASK RPL19

2.70e-03174202263e6d9c3d59ffc1e88baa1fd20b8c0e5be46ffa
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-mature_NK_T_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

APLP1 RPL19

2.70e-031742025c69447261c5aa309a24882656da90655728d637
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4-Tnaive/CM_CD4|GI_small-bowel / Manually curated celltypes from each tissue

CSGALNACT1 RPL19

2.73e-031752024b77e9cf712c9e3b4fb68462a96aea47be124e8d
ToppCelldroplet-Liver-LIVER-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSGALNACT1 KLHL23

2.76e-031762024880fa20b50eb10358e08567e08559ef2954f237
ToppCelldroplet-Kidney-nan-18m-Endothelial-kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APLP1 CSGALNACT1

2.76e-031762025386386619cf173939d3c117b20e6f27ab397993
ToppCelldroplet-Liver-LIVER-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSGALNACT1 KLHL23

2.76e-03176202fcdddd949ca05b3ecde240db9e38296a6eab2d6a
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PASK CSGALNACT1

2.76e-0317620203d194c9814e12802cd932afade69e868814cb78
ToppCellControl-Lymphocyte-T_NK-CD8_TCM|Control / Disease, Lineage and Cell Type

PASK RPL19

2.76e-031762021a7948eb86ee1da607db4d0576312b2859d94523
ToppCell10x5'v1-week_14-16-Myeloid_DC-DC-tDC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

BDKRB2 TRPM1

2.76e-03176202fb07a047a3a7a8d03bfcc28eea3da2eaa0f6b733
ToppCelldroplet-Liver-LIVER-30m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSGALNACT1 KLHL23

2.76e-031762024d2fb51e71bed0d72f3d7f89d395744860885a5f
ToppCelldroplet-Kidney-nan-18m-Endothelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APLP1 CSGALNACT1

2.76e-03176202820edade963768e4bfd86b554da4cd7100567ac8
ToppCell3'-Adult-SmallIntestine-Hematopoietic-Plasma_cells-IgA_plasma_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IRF2 APLP1

2.79e-03177202b326376e879afef579b1b7094d756aaff0de270b
ToppCell3'-Adult-SmallIntestine-Hematopoietic-Plasma_cells|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IRF2 APLP1

2.79e-03177202393882f1bf7658a17e10a771b803339f16fb2e69
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IRF1 APLP1

2.79e-031772021dc69c661e70e7e22bd9d7cf953eb638da9fd43c
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PASK APLP1

2.79e-03177202fd4a297e519b3959811a462d63feebff76429031
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

APLP1 RPL19

2.79e-03177202fcf9138eb95de554fa70243ff282cb4c54c1d3fc
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IRF1 APLP1

2.79e-03177202426a9845df7fd13b02e744532c336c60bc4d4a22
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-regulatory_T_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PASK APLP1

2.79e-03177202e995230ef207dcd87eab4550617589016ffa9970
ToppCelldroplet-Lung-nan-21m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APLP1 RPL19

2.82e-03178202c973818aa6b79127267c95294c09c70ab3e2fd07
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IRF1 MPC1L

2.82e-031782020fb36679cddc9ed8f4b5b34e174d5133c2ea1c76
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PASK CSGALNACT1

2.82e-03178202a62137d7f5fac16619f8a02844cdb0be7a794bf2
ToppCelldroplet-Lung-nan-21m-Lymphocytic-CD4+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

APLP1 RPL19

2.82e-03178202ada794cb77e09faf80539616adeb32b38999f667
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD4-positive,_alpha-beta_T_cell-CD4_T_cells-CD4_T_cells_L.1.1.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PASK RPL19

2.85e-0317920223e2ec64ff8384c29b9c0abfb05c4694a37c6a8e
ToppCellNeuroendocrine-neuroendo-1|World / Class top

APLP1 CSGALNACT1

2.88e-0318020250fdd182a083380899b5943cb5f55ffd77e2a7d4
ToppCellfacs-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Car3+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IRF1 BDKRB2

2.88e-0318020212537d8a569faa69f474284d2c201475722b8ca1
ToppCellSmart-seq2-spleen_(Smart-seq2)-lymphocytic-T_lymphocytic-CD4-positive,_alpha-beta_memory_T_cell|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PASK RPL19

2.92e-03181202ddbfa99b8906fbf2d070f87d905bda1af2200601
ToppCell367C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell|367C / Donor, Lineage, Cell class and subclass (all cells)

PASK RPL19

2.92e-031812029b155a74e68e485039a5195144a12833f2f75058
ToppCell5'-Adult-Appendix-Hematopoietic-T_cells-SELL+_CD4_T|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PASK RPL19

2.92e-0318120204ed65362737e3e70134342127a3f4134a0e2eef
ToppCell(2)_NK/T-(230)_CD4+/CD25+_Reg_T_cell|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)

ZC3H7A CSGALNACT1

2.92e-03181202ad14c7111d4fb924afd233cb114447f195373a7c
ToppCellHealthy-CD8+_T_naive|World / disease group, cell group and cell class

PASK RPL19

2.95e-03182202b7d9f02c29c92c8803e11f967ad6eea032cb4224
ToppCell3'_v3-bone_marrow-Lymphocytic_T_CD4-Tfh|bone_marrow / Manually curated celltypes from each tissue

PASK RPL19

2.95e-03182202c059e79da49db3649052581d95255f03e2956144
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

APLP1 RPL19

2.95e-03182202c1665cd9b28fec4bfe4e3981d7992d660f37b97f
ToppCellHealthy-CD8+_T_naive|Healthy / disease group, cell group and cell class

PASK RPL19

2.98e-031832025e7a611cfb8a21106bb07361878ccc77ff251502
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-T_cells-SELL+_CD8_T|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PASK RPL19

2.98e-03183202b59373849cac62564e9054b7f191f1a1086ca187
ToppCell5'-Adult-LargeIntestine-Hematopoietic-T_cells-SELL+_CD8_T|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PASK RPL19

3.01e-03184202d5b8604142ae70abbfa4ea881ce55b2a3a2a46a6
ToppCellILEUM-non-inflamed-(1)_Central_Memory_T_cells|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PASK RPL19

3.01e-0318420262b7a1a9b61e29b7f2ea144c9096db80b49fe320
ToppCellCOVID-19_Convalescent-Lymphoid_T/NK-CD8+_T_naive|COVID-19_Convalescent / Disease group, lineage and cell class

PASK RPL19

3.01e-031842020299cd30a3ea8e861a9d529043c204048ae21d29
ToppCellCOVID-CD4-naive_CD4|COVID / Condition, Cell_class and T cell subcluster

PASK RPL19

3.01e-0318420200db55970d336a301035efe43a4ab4db62627f38
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)

PASK RPL19

3.04e-03185202863a3d44c1f115942d7a2a2b63a92fe5fc768814
ToppCellSmart-seq2-spleen_(Smart-seq2)-lymphocytic-T_lymphocytic-naive_thymus-derived_CD4-positive,_alpha-beta_T_cell|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PASK RPL19

3.04e-03185202608c16c0ff251926e3e62a6cb66f835163302538
ToppCellPBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PASK RPL19

3.04e-0318520227dbfcd40ec832d5cf757331d8af3b5176ae90fb
ComputationalGenes in the cancer module 486.

PRPF8 APLP1 BDKRB2

1.62e-04100123MODULE_486
ComputationalNeighborhood of EIF4A2

PRPF8 OXA1L RPL19

4.18e-04138123MORF_EIF4A2
Diseaseretinitis pigmentosa (is_implicated_in)

PRPF8 POMGNT1

3.52e-0441202DOID:10584 (is_implicated_in)
DiseaseDisorder of eye

PRPF8 OPA3 TRPM1

3.81e-04212203C0015397
DiseaseAcute Cerebrovascular Accidents

PRPF8 IRF1

6.12e-0454202C0751956
DiseaseCerebrovascular accident

PRPF8 IRF1

8.05e-0462202C0038454
Diseasecholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement

OPA3 CSGALNACT1

2.20e-03103202EFO_0008595, EFO_0020944
DiseaseRetinitis Pigmentosa

PRPF8 POMGNT1

2.24e-03104202C0035334
Diseaseeosinophil measurement

IRF1 CSGALNACT1

2.42e-03108202EFO_0803540
Diseasecholesterol:total lipids ratio, intermediate density lipoprotein measurement

OPA3 CSGALNACT1

3.02e-03121202EFO_0008595, EFO_0020943
Diseaseasthma (is_marker_for)

IRF1 BDKRB2

3.27e-03126202DOID:2841 (is_marker_for)
Diseaseasthma (is_implicated_in)

IRF1 BDKRB2

5.02e-03157202DOID:2841 (is_implicated_in)
Diseaseepilepsy (implicated_via_orthology)

BDKRB2 DEPDC5

5.40e-03163202DOID:1826 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
KTMSMGRMRGVRWAK

BDKRB2

161

P30411
MMMVRRGLLAWISRV

CSGALNACT1

1

Q8TDX6
RMRQINEVMREWAMA

APLP1

321

P51693
MPITRMRMRPWLEMQ

IRF1

1

P10914
MPVERMRMRPWLEEQ

IRF2

1

P14316
MPMKLTSNRRRWMHT

DEPDC5

606

O75140
IPVSVWMKRMRQERR

PASK

211

Q96RG2
AASVWKRKRMDRMMV

MAEA

116

Q7L5Y9
MARMAVLWRKMRDNF

MPC1L

1

P0DKB6
AWKPRMNRKSRSRMR

LRRC37A5P

91

Q49AS3
WVEMRTKMRIMGFRG

OPA3

51

Q9H6K4
QWMRNVIRMMPLITL

OXA1L

291

Q15070
NEWREIAPMMERRME

KLHL23

486

Q8NBE8
DMWMRMPEQRRGREC

POMGNT1

476

Q8WZA1
NARMPEKVTWMRRMR

RPL19

86

P84098
SMWIMMRREKRDRRH

PRPF8

146

Q6P2Q9
MRRTRRPRFVLMNKM

SPRYD3

1

Q8NCJ5
VRMNGKTRLMQWRDM

TTC13

551

Q8NBP0
MLLTDMWMGRLRMRK

TRPM1

731

Q7Z4N2
MRVMSIERKKWMNIR

ZC3H7A

746

Q8IWR0
PLHRAWRMMNFRQRM

TMEM251

26

Q8N6I4