Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionSUMO ligase activity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.41e-1220396GO:0061665
GeneOntologyMolecularFunctionsmall GTPase binding

RGPD1 RGPD4 RGPD2 RANBP2 NCF2 NOX1 ASB14 RGPD8 CHM DOCK9 RGPD3

1.75e-113213911GO:0031267
GeneOntologyMolecularFunctionGTPase binding

RGPD1 RGPD4 RGPD2 RANBP2 NCF2 NOX1 ASB14 RGPD8 CHM DOCK9 RGPD3

6.00e-113603911GO:0051020
GeneOntologyMolecularFunctionSUMO transferase activity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

6.92e-1136396GO:0019789
GeneOntologyMolecularFunctionpeptidyl-prolyl cis-trans isomerase activity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

5.54e-1050396GO:0003755
GeneOntologyMolecularFunctioncis-trans isomerase activity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

7.97e-1053396GO:0016859
GeneOntologyMolecularFunctionGTPase activator activity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 CHM RGPD3 RGPD5

5.55e-08279398GO:0005096
GeneOntologyMolecularFunctionGTPase regulator activity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 CHM DOCK9 RGPD3 RGPD5

4.39e-07507399GO:0030695
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 CHM DOCK9 RGPD3 RGPD5

4.39e-07507399GO:0060589
GeneOntologyMolecularFunctionisomerase activity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.83e-06192396GO:0016853
GeneOntologyMolecularFunctionenzyme activator activity

RGPD1 RGPD4 RGPD2 RANBP2 NCF2 RGPD8 CHM RGPD3 RGPD5

3.70e-06656399GO:0008047
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

RGPD1 RGPD4 RGPD2 RNF213 RANBP2 RGPD8 RGPD3

1.05e-05398397GO:0061659
GeneOntologyMolecularFunctionhistone H3K9 trimethyltransferase activity

SUV39H2 SUV39H1

3.70e-055392GO:0140949
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

RGPD1 RGPD4 RGPD2 RNF213 RANBP2 RGPD8 RGPD3

5.28e-05512397GO:0019787
GeneOntologyMolecularFunctionenzyme regulator activity

RGPD1 RGPD4 RGPD2 NCOR1 RANBP2 NCF2 RGPD8 CHM DOCK9 RGPD3 RGPD5

5.84e-0514183911GO:0030234
GeneOntologyMolecularFunctionaminoacyltransferase activity

RGPD1 RGPD4 RGPD2 RNF213 RANBP2 RGPD8 RGPD3

6.72e-05532397GO:0016755
GeneOntologyMolecularFunctionmolecular function activator activity

RGPD1 RGPD4 RGPD2 RANBP2 NCF2 RGPD8 CHM DNAJC7 RGPD3 RGPD5

9.50e-0512333910GO:0140677
GeneOntologyMolecularFunctionacyltransferase activity

RGPD1 RGPD4 RGPD2 RNF213 RANBP2 RGPD8 KAT8 RGPD3

1.05e-04775398GO:0016746
GeneOntologyMolecularFunctionhistone H3K9me2 methyltransferase activity

SUV39H2 SUV39H1

1.66e-0410392GO:0140947
GeneOntologyMolecularFunctionsuperoxide-generating NAD(P)H oxidase activity

NCF2 NOX1

2.42e-0412392GO:0016175
GeneOntologyMolecularFunctionhistone H3K9 methyltransferase activity

SUV39H2 SUV39H1

2.86e-0413392GO:0046974
GeneOntologyMolecularFunctionoxidoreductase activity, acting on NAD(P)H, oxygen as acceptor

NCF2 NOX1

6.91e-0420392GO:0050664
GeneOntologyMolecularFunctionnuclear retinoid X receptor binding

NCOR1 NCOR2

9.16e-0423392GO:0046965
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

SUV39H2 SUV39H1

3.34e-0344392GO:0140938
GeneOntologyMolecularFunctionnuclear retinoic acid receptor binding

NCOR1 NCOR2

5.17e-0355392GO:0042974
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

SUV39H2 SUV39H1

7.81e-0368392GO:0016279
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

SUV39H2 SUV39H1

8.03e-0369392GO:0016278
GeneOntologyMolecularFunctionhistone methyltransferase activity

SUV39H2 SUV39H1

8.48e-0371392GO:0042054
GeneOntologyMolecularFunctionhistone modifying activity

SUV39H2 KAT8 SUV39H1

1.00e-02229393GO:0140993
GeneOntologyMolecularFunctiontranscription corepressor activity

NCOR1 NCOR2 KCTD1

1.00e-02229393GO:0003714
GeneOntologyBiologicalProcesspositive regulation of glucokinase activity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

2.55e-159396GO:0033133
GeneOntologyBiologicalProcessNLS-bearing protein import into nucleus

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD5

3.72e-1520397GO:0006607
GeneOntologyBiologicalProcesspositive regulation of hexokinase activity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

6.38e-1510396GO:1903301
GeneOntologyBiologicalProcessregulation of glucokinase activity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

5.19e-1413396GO:0033131
GeneOntologyBiologicalProcessregulation of hexokinase activity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

9.07e-1414396GO:1903299
GeneOntologyBiologicalProcessprotein peptidyl-prolyl isomerization

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

8.07e-1138396GO:0000413
GeneOntologyBiologicalProcesspeptidyl-proline modification

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

7.38e-1054396GO:0018208
GeneOntologyBiologicalProcessprotein import into nucleus

RGPD1 RGPD4 RGPD2 RANBP2 SPG11 RGPD8 RGPD3 RGPD5

2.65e-09195398GO:0006606
GeneOntologyBiologicalProcessimport into nucleus

RGPD1 RGPD4 RGPD2 RANBP2 SPG11 RGPD8 RGPD3 RGPD5

3.36e-09201398GO:0051170
GeneOntologyBiologicalProcessregulation of gluconeogenesis

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

4.00e-0971396GO:0006111
GeneOntologyBiologicalProcessRNA transport

RGPD1 CKAP5 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

3.43e-08175397GO:0050658
GeneOntologyBiologicalProcessnucleic acid transport

RGPD1 CKAP5 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

3.43e-08175397GO:0050657
GeneOntologyBiologicalProcessestablishment of RNA localization

RGPD1 CKAP5 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

3.86e-08178397GO:0051236
GeneOntologyBiologicalProcessgluconeogenesis

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

5.98e-08111396GO:0006094
GeneOntologyBiologicalProcesshexose biosynthetic process

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

7.40e-08115396GO:0019319
GeneOntologyBiologicalProcessmonosaccharide biosynthetic process

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.00e-07121396GO:0046364
GeneOntologyBiologicalProcessRNA localization

RGPD1 CKAP5 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.50e-07217397GO:0006403
GeneOntologyBiologicalProcessregulation of carbohydrate biosynthetic process

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.68e-07132396GO:0043255
GeneOntologyBiologicalProcessregulation of glucose metabolic process

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.84e-07134396GO:0010906
GeneOntologyBiologicalProcessregulation of carbohydrate metabolic process

RGPD1 RGPD4 RGPD2 NCOR1 RANBP2 RGPD8 RGPD3

2.29e-07231397GO:0006109
GeneOntologyBiologicalProcessintracellular transport

RGPD1 RGPD4 RGPD2 TRAPPC11 RANBP2 SPG11 ASB14 REEP1 RGPD8 CHM LYST PICK1 RGPD3 RGPD5

2.82e-0714963914GO:0046907
GeneOntologyBiologicalProcessmRNA transport

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

2.93e-07145396GO:0051028
GeneOntologyBiologicalProcessprotein localization to nucleus

RGPD1 RGPD4 RGPD2 RANBP2 SPG11 RGPD8 RGPD3 RGPD5

3.19e-07362398GO:0034504
GeneOntologyBiologicalProcessprotein folding

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 DNAJC7 RGPD3

3.50e-07246397GO:0006457
GeneOntologyBiologicalProcessnucleobase-containing compound transport

RGPD1 CKAP5 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

3.80e-07249397GO:0015931
GeneOntologyBiologicalProcessnuclear transport

RGPD1 RGPD4 RGPD2 RANBP2 SPG11 RGPD8 RGPD3 RGPD5

4.42e-07378398GO:0051169
GeneOntologyBiologicalProcessnucleocytoplasmic transport

RGPD1 RGPD4 RGPD2 RANBP2 SPG11 RGPD8 RGPD3 RGPD5

4.42e-07378398GO:0006913
GeneOntologyBiologicalProcessintracellular protein transport

RGPD1 RGPD4 RGPD2 RANBP2 SPG11 RGPD8 CHM PICK1 RGPD3 RGPD5

8.23e-077403910GO:0006886
GeneOntologyBiologicalProcessnuclear export

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.22e-06185396GO:0051168
GeneOntologyBiologicalProcessregulation of small molecule metabolic process

RGPD1 RGPD4 RGPD2 NCOR1 NCOR2 RANBP2 RGPD8 RGPD3

1.25e-06434398GO:0062012
GeneOntologyBiologicalProcessestablishment of protein localization to organelle

RGPD1 RGPD4 RGPD2 RANBP2 SPG11 RGPD8 RGPD3 RGPD5

4.45e-06515398GO:0072594
GeneOntologyBiologicalProcessglucose metabolic process

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

6.06e-06244396GO:0006006
GeneOntologyBiologicalProcesscarbohydrate biosynthetic process

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

6.50e-06247396GO:0016051
GeneOntologyBiologicalProcesshexose metabolic process

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.44e-05284396GO:0019318
GeneOntologyBiologicalProcessmonosaccharide metabolic process

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

2.36e-05310396GO:0005996
GeneOntologyBiologicalProcesspositive regulation of kinase activity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.04e-04405396GO:0033674
GeneOntologyBiologicalProcessprotein maturation

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 DNAJC7 RGPD3

1.41e-04619397GO:0051604
GeneOntologyBiologicalProcesscarbohydrate metabolic process

RGPD1 RGPD4 RGPD2 NCOR1 RANBP2 RGPD8 RGPD3

1.84e-04646397GO:0005975
GeneOntologyBiologicalProcesspositive regulation of transferase activity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

2.92e-04490396GO:0051347
GeneOntologyBiologicalProcessepigenetic programming in the zygotic pronuclei

SUV39H2 SUV39H1

4.65e-0417392GO:0044725
GeneOntologyBiologicalProcessnegative regulation of androgen receptor signaling pathway

NCOR1 NCOR2

4.65e-0417392GO:0060766
GeneOntologyBiologicalProcesscellular response to oxygen levels

NOX1 SUV39H2 PICK1 SUV39H1

4.92e-04195394GO:0071453
GeneOntologyBiologicalProcessregulation of microtubule nucleation

CKAP5 HAUS3

5.84e-0419392GO:0010968
GeneOntologyBiologicalProcessregulation of multicellular organism growth

NCOR1 AZGP1 SUV39H1

7.21e-0493393GO:0040014
GeneOntologyBiologicalProcessendocytosis

CKAP5 MRC1 NCF2 SPG11 FER1L5 LYST PICK1

8.13e-04827397GO:0006897
GeneOntologyBiologicalProcessprotein localization to organelle

RGPD1 RGPD4 RGPD2 RANBP2 SPG11 RGPD8 RGPD3 RGPD5

8.47e-041091398GO:0033365
GeneOntologyBiologicalProcessdendritic spine maintenance

CKAP5 PICK1

1.47e-0330392GO:0097062
GeneOntologyBiologicalProcessregulation of androgen receptor signaling pathway

NCOR1 NCOR2

1.56e-0331392GO:0060765
GeneOntologyBiologicalProcessnegative regulation of miRNA transcription

NCOR1 NCOR2

1.56e-0331392GO:1902894
GeneOntologyBiologicalProcesssmall molecule biosynthetic process

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.57e-03676396GO:0044283
GeneOntologyBiologicalProcessregulation of kinase activity

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.69e-03686396GO:0043549
GeneOntologyBiologicalProcessphagocytosis

NCF2 SPG11 FER1L5 LYST

1.74e-03274394GO:0006909
GeneOntologyBiologicalProcessnegative regulation of miRNA metabolic process

NCOR1 NCOR2

1.88e-0334392GO:2000629
GeneOntologyCellularComponentcytoplasmic periphery of the nuclear pore complex

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

7.87e-168396GO:1990723
GeneOntologyCellularComponentnuclear pore cytoplasmic filaments

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

5.88e-1510396GO:0044614
GeneOntologyCellularComponentannulate lamellae

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

8.37e-1414396GO:0005642
GeneOntologyCellularComponentnuclear pore nuclear basket

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

5.15e-1318396GO:0044615
GeneOntologyCellularComponentnuclear inclusion body

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.07e-1220396GO:0042405
GeneOntologyCellularComponentSUMO ligase complex

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.50e-1221396GO:0106068
GeneOntologyCellularComponentnuclear pore

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD5

6.74e-10101397GO:0005643
GeneOntologyCellularComponentinclusion body

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.57e-0890396GO:0016234
GeneOntologyCellularComponentnuclear protein-containing complex

RGPD1 RGPD4 RGPD2 NCOR1 NCOR2 RANBP2 RGPD8 KAT8 SUV39H1 RGPD3 RGPD5

2.93e-0513773911GO:0140513
GeneOntologyCellularComponentnuclear membrane

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

4.25e-05349396GO:0031965
GeneOntologyCellularComponentperinuclear region of cytoplasm

RGPD1 RGPD4 RGPD2 NCOR1 RANBP2 RGPD8 P2RX4 PICK1 RGPD3

4.31e-05934399GO:0048471
GeneOntologyCellularComponentnuclear envelope

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD5

6.97e-05560397GO:0005635
GeneOntologyCellularComponenttransferase complex

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 CHM KAT8 RGPD3

3.39e-04963398GO:1990234
GeneOntologyCellularComponentNADPH oxidase complex

NCF2 NOX1

5.09e-0418392GO:0043020
GeneOntologyCellularComponentchromosome, centromeric region

CKAP5 SUV39H2 KAT8 SUV39H1

1.70e-03276394GO:0000775
GeneOntologyCellularComponentnuclear periphery

NCOR2 KAT8 SUV39H1

3.96e-03171393GO:0034399
GeneOntologyCellularComponentorganelle envelope

RGPD1 RGPD4 RGPD2 RANBP2 REEP1 RGPD8 RGPD3 RGPD5

4.39e-031435398GO:0031967
HumanPhenoThenar muscle atrophy

SPG11 NEB REEP1

3.36e-0615113HP:0003393
HumanPhenoAbnormal calf musculature morphology

TRAPPC11 SPG11 NEB REEP1

1.06e-0571114HP:0001430
HumanPhenoMotor polyneuropathy

SPG11 REEP1 LYST

6.07e-0538113HP:0007178
HumanPhenoBulbar signs

SPG11 NEB REEP1

9.46e-0544113HP:0002483
HumanPhenoAbnormality of the musculature of the hand

TRAPPC11 SPG11 NEB REEP1

9.98e-05125114HP:0001421
HumanPhenoFoot dorsiflexor weakness

SPG11 NEB REEP1 LYST

1.73e-04144114HP:0009027
HumanPhenoHand muscle atrophy

SPG11 NEB REEP1

1.75e-0454113HP:0009130
HumanPhenoAbnormality of the foot musculature

SPG11 NEB REEP1 LYST

2.08e-04151114HP:0001436
HumanPhenoAbnormality of the musculature of the lower limbs

TRAPPC11 SPG11 NEB REEP1 LYST

2.25e-04297115HP:0001437
HumanPhenoImpaired neutrophil bactericidal activity

NCF2 LYST

2.31e-0411112HP:0011993
HumanPhenoAnkle contracture

SPG11 NEB REEP1

2.40e-0460113HP:0034677
HumanPhenoDistal upper limb amyotrophy

SPG11 NEB REEP1

3.48e-0468113HP:0007149
HumanPhenoProximal muscle weakness

TRAPPC11 SPG11 NEB REEP1 LYST

4.25e-04340115HP:0003701
HumanPhenoProximal muscle weakness in lower limbs

SPG11 NEB REEP1 LYST

4.64e-04186114HP:0008994
HumanPhenoAbnormality of neutrophil physiology

NCF2 LYST

5.67e-0417112HP:0011990
HumanPhenoUpper limb amyotrophy

SPG11 NEB REEP1

6.26e-0483113HP:0009129
MousePhenoelevated level of mitotic sister chromatid exchange

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

6.90e-1316326MP:0003701
MousePhenoabnormal morula morphology

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.95e-1126326MP:0012058
MousePhenodecreased tumor latency

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

5.00e-1130326MP:0010308
MousePhenofailure of blastocyst formation

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

6.19e-1131326MP:0012129
MousePhenoabnormal tumor latency

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.13e-1034326MP:0010307
MousePhenoabnormal blastocyst formation

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

2.71e-1039326MP:0012128
MousePhenoaneuploidy

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

4.45e-0961326MP:0004024
MousePhenoabnormal rod electrophysiology

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 CHM RGPD3

7.65e-09119327MP:0004021
MousePhenoincreased hepatocellular carcinoma incidence

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.04e-0870326MP:0003331
MousePhenoabnormal chromosome morphology

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 KAT8 RGPD3

1.14e-08126327MP:0003702
MousePhenoabnormal mitosis

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 KAT8 RGPD3

1.27e-08128327MP:0004046
MousePhenoincreased lung carcinoma incidence

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

2.00e-0878326MP:0008714
MousePhenoabnormal chromosome number

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

3.62e-0886326MP:0004023
MousePhenodecreased susceptibility to diet-induced obesity

RGPD1 RGPD4 RGPD2 NCOR1 RANBP2 RGPD8 RGPD3

5.97e-08160327MP:0005659
MousePhenoenlarged epididymis

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

8.45e-0899326MP:0004931
MousePhenoincreased sarcoma incidence

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.01e-07102326MP:0002032
MousePhenoincreased incidence of induced tumors

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 LYST RGPD3

1.02e-07173327MP:0002021
MousePhenoincreased lung tumor incidence

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.35e-07107326MP:0008014
MousePhenofailure of blastocyst to hatch from the zona pellucida

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.35e-07107326MP:0003694
MousePhenoincreased respiratory system tumor incidence

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.35e-07107326MP:0010298
MousePhenoabnormal cell nucleus morphology

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 KAT8 RGPD3

1.56e-07184327MP:0003111
MousePhenodecreased susceptibility to weight gain

RGPD1 RGPD4 RGPD2 NCOR1 RANBP2 RGPD8 RGPD3

1.68e-07186327MP:0010182
MousePhenoincreased liver tumor incidence

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.68e-07111326MP:0008019
MousePhenoincreased hepatobiliary system tumor incidence

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.68e-07111326MP:0010297
MousePhenoabnormal blastocyst hatching

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.86e-07113326MP:0003693
MousePhenoabnormal intracellular organelle morphology

RGPD1 RGPD4 RGPD2 RANBP2 SPG11 REEP1 RGPD8 LYST KAT8 RGPD3

2.26e-075463210MP:0014239
MousePhenoincreased energy expenditure

RGPD1 RGPD4 RGPD2 NCOR1 RANBP2 RGPD8 RGPD3

2.39e-07196327MP:0004889
MousePhenoabnormal susceptibility to weight gain

RGPD1 RGPD4 RGPD2 NCOR1 NCOR2 RANBP2 RGPD8 RGPD3

3.45e-07309328MP:0011117
MousePhenoabnormal energy expenditure

RGPD1 RGPD4 RGPD2 NCOR1 NCOR2 RANBP2 RGPD8 RGPD3

3.81e-07313328MP:0005450
MousePhenoabnormal energy homeostasis

RGPD1 RGPD4 RGPD2 NCOR1 NCOR2 RANBP2 RGPD8 RGPD3

4.72e-07322328MP:0005448
MousePhenoabnormal eye electrophysiology

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 CHM RGPD3

6.66e-07228327MP:0005551
MousePhenoincreased incidence of tumors by chemical induction

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

6.91e-07141326MP:0004499
MousePhenoincreased classified tumor incidence

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 SUV39H2 SUV39H1 RGPD3

1.68e-06381328MP:0010273
MousePhenoabnormal classified tumor incidence

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 SUV39H2 SUV39H1 RGPD3

1.78e-06384328MP:0020188
MousePhenoabnormal epididymis size

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.80e-06166326MP:0004926
MousePhenoincreased tumor incidence

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 LYST SUV39H2 SUV39H1 RGPD3

1.94e-06530329MP:0002020
MousePhenoabnormal incidence of induced tumors

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 LYST RGPD3

2.02e-06269327MP:0013151
MousePhenoabnormal preimplantation embryo development

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

2.14e-06171326MP:0009781
MousePhenoincreased organ/body region tumor incidence

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 SUV39H2 SUV39H1 RGPD3

2.20e-06395328MP:0010274
MousePhenoabnormal organ/body region tumor incidence

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 SUV39H2 SUV39H1 RGPD3

2.46e-06401328MP:0013152
MousePhenoabnormal preimplantation embryo morphology

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 CHM RGPD3

2.82e-06283327MP:0014137
MousePhenoincreased carcinoma incidence

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

4.85e-06197326MP:0002038
MousePhenoembryonic lethality before implantation, complete penetrance

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

5.76e-06203326MP:0011094
MousePhenoabnormal tumor incidence

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 LYST SUV39H2 SUV39H1 RGPD3

8.52e-06635329MP:0002019
MousePhenoabnormal tumor susceptibility

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 LYST SUV39H2 SUV39H1 RGPD3

1.03e-05650329MP:0002166
MousePhenoincreased malignant tumor incidence

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.40e-05237326MP:0002018
MousePhenoembryonic lethality before implantation

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.57e-05242326MP:0006204
MousePhenoabnormal epididymis morphology

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

2.86e-05269326MP:0002631
MousePhenoneoplasm

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 LYST SUV39H2 SUV39H1 RGPD3

3.12e-05747329MP:0002006
MousePhenoincreased physiological sensitivity to xenobiotic

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

4.03e-05286326MP:0008873
MousePhenoabnormal eye physiology

RGPD1 RGPD4 RGPD2 RANBP2 KCTD1 RGPD8 CHM RGPD3

4.97e-05606328MP:0005253
MousePhenoabnormal cell cycle

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 KAT8 RGPD3

1.42e-04520327MP:0003077
MousePhenoembryonic lethality prior to organogenesis

RGPD1 CKAP5 RGPD4 MRC1 RGPD2 TRAPPC11 RANBP2 RGPD8 KAT8 RGPD3

2.39e-0412043210MP:0013292
MousePhenoembryonic lethality prior to organogenesis, complete penetrance

RGPD1 RGPD4 MRC1 RGPD2 RANBP2 RGPD8 KAT8 RGPD3

2.68e-04772328MP:0014259
MousePhenoembryonic lethality prior to tooth bud stage, complete penetrance

RGPD1 RGPD4 MRC1 RGPD2 RANBP2 RGPD8 KAT8 RGPD3

2.85e-04779328MP:0014257
MousePhenoabnormal physiological response to xenobiotic

RGPD1 RGPD4 RGPD2 NCOR2 RANBP2 RGPD8 RGPD3

6.17e-04662327MP:0008872
MousePhenoimpaired glucose tolerance

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

6.73e-04480326MP:0005293
MousePhenoabnormal embryo development

RGPD1 CKAP5 RGPD4 RGPD2 NCOR2 RANBP2 RGPD8 CHM KAT8 RGPD3

6.79e-0413703210MP:0001672
MousePhenoembryonic lethality prior to tooth bud stage

RGPD1 CKAP5 RGPD4 MRC1 RGPD2 TRAPPC11 RANBP2 RGPD8 KAT8 RGPD3

7.32e-0413833210MP:0013293
MousePhenoabnormal liver morphology

RGPD1 RGPD4 RGPD2 NCOR1 NCOR2 RANBP2 RGPD8 DNAJC7 KAT8 RGPD3

9.67e-0414333210MP:0000598
MousePhenoabnormal hepatobiliary system morphology

RGPD1 RGPD4 RGPD2 NCOR1 NCOR2 RANBP2 RGPD8 DNAJC7 KAT8 RGPD3

1.22e-0314763210MP:0002138
MousePhenoabnormal lung morphology

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 LYST RGPD3

1.47e-03767327MP:0001175
MousePhenosmall testis

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 PICK1 RGPD3

2.20e-03823327MP:0001147
MousePhenoabnormal susceptibility to fungal infection

NCF2 LYST

2.26e-0331322MP:0020183
MousePhenoabnormal white fat cell morphology

NCOR1 NCOR2 REEP1

3.00e-03127323MP:0009117
DomainRan_BP1

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD5

7.70e-1712397PF00638
DomainRANBD1

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD5

7.70e-1712397PS50196
DomainRanBD

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD5

1.66e-1613397SM00160
DomainRan_bind_dom

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD5

1.66e-1613397IPR000156
DomainTPR-contain_dom

RGPD1 RGPD4 TTC27 RGPD2 RANBP2 NCF2 RGPD8 DNAJC7 EDRF1 RGPD3 RGPD5

8.55e-151503911IPR013026
DomainTPR

RGPD1 RGPD4 TTC27 RGPD2 RANBP2 NCF2 RGPD8 DNAJC7 EDRF1 RGPD3 RGPD5

2.47e-141653911PS50005
DomainTPR_REGION

RGPD1 RGPD4 TTC27 RGPD2 RANBP2 NCF2 RGPD8 DNAJC7 EDRF1 RGPD3 RGPD5

2.47e-141653911PS50293
DomainGRIP

RGPD1 RGPD4 RGPD2 RGPD8 RGPD3 RGPD5

2.54e-1411396PF01465
DomainGrip

RGPD1 RGPD4 RGPD2 RGPD8 RGPD3 RGPD5

2.54e-1411396SM00755
DomainGRIP_dom

RGPD1 RGPD4 RGPD2 RGPD8 RGPD3 RGPD5

5.07e-1412396IPR000237
DomainGRIP

RGPD1 RGPD4 RGPD2 RGPD8 RGPD3 RGPD5

5.07e-1412396PS50913
DomainGCC2_Rab_bind

RGPD1 RGPD4 RGPD2 RGPD8 RGPD3

6.37e-137395IPR032023
DomainRab_bind

RGPD1 RGPD4 RGPD2 RGPD8 RGPD3

6.37e-137395PF16704
DomainTPR-like_helical_dom

RGPD1 RGPD4 TTC27 RGPD2 RANBP2 NCF2 RGPD8 DNAJC7 EDRF1 RGPD3 RGPD5

1.11e-122333911IPR011990
DomainTPR

RGPD1 RGPD4 TTC27 RGPD2 RANBP2 NCF2 RGPD8 DNAJC7 RGPD3

4.80e-12129399SM00028
DomainTPR_repeat

RGPD1 RGPD4 TTC27 RGPD2 RANBP2 NCF2 RGPD8 DNAJC7 RGPD3

6.33e-12133399IPR019734
Domain-

RGPD1 RGPD4 RGPD2 RGPD8 RGPD3

7.61e-12103951.10.220.60
Domain-

RGPD1 RGPD4 TTC27 RGPD2 RANBP2 NCF2 RGPD8 DNAJC7 EDRF1 RGPD3

1.08e-1120739101.25.40.10
DomainTPR_1

RGPD1 RANBP2 NCF2 RGPD8 DNAJC7 RGPD5

3.04e-0890396PF00515
DomainTPR_1

RGPD1 RANBP2 NCF2 RGPD8 DNAJC7 RGPD5

3.04e-0890396IPR001440
DomainPH_dom-like

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 LYST DOCK9 RGPD3 RGPD5

1.77e-07426399IPR011993
DomainSAM_MT43_SUVAR39_3

SUV39H2 SUV39H1

4.25e-062392PS51579
DomainHistone_H3-K9_MeTrfase

SUV39H2 SUV39H1

4.25e-062392IPR011381
DomainGPS2_interact

NCOR1 NCOR2

4.25e-062392PF15784
DomainN-CoR_GPS2_interact

NCOR1 NCOR2

4.25e-062392IPR031557
Domain-

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 DOCK9 RGPD3

1.44e-053913972.30.29.30
DomainCHROMO_2

SUV39H2 KAT8 SUV39H1

2.66e-0528393PS50013
DomainCHROMO_1

SUV39H2 KAT8 SUV39H1

2.66e-0528393PS00598
DomainChromodomain-like

SUV39H2 KAT8 SUV39H1

4.00e-0532393IPR016197
DomainCHROMO

SUV39H2 KAT8 SUV39H1

4.40e-0533393SM00298
DomainChromo/shadow_dom

SUV39H2 KAT8 SUV39H1

4.40e-0533393IPR000953
DomainPreSET

SUV39H2 SUV39H1

8.86e-057392SM00468
DomainPre-SET

SUV39H2 SUV39H1

8.86e-057392PF05033
DomainPre-SET_dom

SUV39H2 SUV39H1

8.86e-057392IPR007728
DomainPRE_SET

SUV39H2 SUV39H1

8.86e-057392PS50867
DomainPost-SET_dom

SUV39H2 SUV39H1

5.01e-0416392IPR003616
DomainPostSET

SUV39H2 SUV39H1

5.01e-0416392SM00508
DomainPOST_SET

SUV39H2 SUV39H1

5.01e-0416392PS50868
DomainChromodomain_CS

SUV39H2 SUV39H1

6.36e-0418392IPR023779
DomainChromo_domain

SUV39H2 SUV39H1

1.14e-0324392IPR023780
DomainChromo

SUV39H2 SUV39H1

1.34e-0326392PF00385
DomainSANT_dom

NCOR1 NCOR2

1.34e-0326392IPR017884
DomainSANT

NCOR1 NCOR2

1.55e-0328392PS51293
DomainMyb_DNA-binding

NCOR1 NCOR2

2.42e-0335392PF00249
DomainMYB_LIKE

NCOR1 NCOR2

2.85e-0338392PS50090
DomainSET

SUV39H2 SUV39H1

3.31e-0341392PF00856
DomainSET

SUV39H2 SUV39H1

4.15e-0346392SM00317
DomainSET_dom

SUV39H2 SUV39H1

4.89e-0350392IPR001214
DomainSANT

NCOR1 NCOR2

4.89e-0350392SM00717
DomainSET

SUV39H2 SUV39H1

4.89e-0350392PS50280
DomainSANT/Myb

NCOR1 NCOR2

5.27e-0352392IPR001005
DomainTPR_8

NCF2 DNAJC7

5.47e-0353392PF13181
PathwayBIOCARTA_RANBP2_PATHWAY

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.52e-1218326MM1549
PathwayREACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

3.03e-1040326MM14945
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

3.54e-1041326MM15200
PathwayREACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

4.12e-1042326MM15039
PathwayREACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

4.79e-1043326MM14609
PathwayREACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

8.37e-1047326MM14939
PathwayREACTOME_GENE_SILENCING_BY_RNA

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.09e-0949326MM14837
PathwayREACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.23e-0950326MM14610
PathwayREACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.40e-0951326MM15151
PathwayREACTOME_AMPLIFICATION_OF_SIGNAL_FROM_THE_KINETOCHORES

RGPD1 CKAP5 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

2.13e-09100327MM14561
PathwayREACTOME_NUCLEAR_ENVELOPE_BREAKDOWN

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

2.23e-0955326MM14917
PathwayREACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

3.10e-0958326MM15149
PathwayREACTOME_SNRNP_ASSEMBLY

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

3.10e-0958326MM14736
PathwayREACTOME_RHO_GTPASE_EFFECTORS

RGPD1 CKAP5 RGPD4 RGPD2 RANBP2 NCF2 NOX1 RGPD8 RGPD3

3.76e-09257329MM14755
PathwayREACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

6.26e-0965326MM15147
PathwayREACTOME_MITOTIC_SPINDLE_CHECKPOINT

RGPD1 CKAP5 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

6.42e-09117327MM15387
PathwayREACTOME_MITOTIC_PROMETAPHASE

RGPD1 CKAP5 RGPD4 RGPD2 RANBP2 HAUS3 RGPD8 RGPD3

1.21e-08202328MM15362
PathwayREACTOME_RESOLUTION_OF_SISTER_CHROMATID_COHESION

RGPD1 CKAP5 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.27e-08129327MM14894
PathwayREACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.27e-0873326MM14948
PathwayREACTOME_RHO_GTPASES_ACTIVATE_FORMINS

RGPD1 CKAP5 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

2.36e-08141327MM15266
PathwayREACTOME_GLUCOSE_METABOLISM

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

2.58e-0882326MM15394
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

2.99e-0884326MM14929
PathwayREACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

3.45e-0886326MM15413
PathwayREACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

5.18e-0892326MM14951
PathwayREACTOME_MITOTIC_PROPHASE

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.87e-07114326MM15361
PathwayREACTOME_SEPARATION_OF_SISTER_CHROMATIDS

RGPD1 CKAP5 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

2.04e-07193327MM14890
PathwayREACTOME_MITOTIC_METAPHASE_AND_ANAPHASE

RGPD1 CKAP5 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

7.50e-07234327MM14898
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

RGPD1 CKAP5 RGPD4 RGPD2 RANBP2 NCF2 NOX1 RGPD8 DOCK9 RGPD3

1.03e-066493210MM15690
PathwayREACTOME_M_PHASE

RGPD1 CKAP5 RGPD4 RGPD2 RANBP2 HAUS3 RGPD8 RGPD3

1.77e-06387328MM15364
PathwayREACTOME_SUMOYLATION

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.90e-06169326MM14919
PathwayREACTOME_CELL_CYCLE_CHECKPOINTS

RGPD1 CKAP5 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

2.00e-06271327MM15388
PathwayREACTOME_GENE_EXPRESSION_TRANSCRIPTION

RGPD1 RGPD4 RGPD2 NCOR2 RANBP2 KCTD1 RGPD8 CHM KAT8 RGPD3 ZFP1

8.60e-0610223211MM15436
PathwayREACTOME_CELLULAR_RESPONSES_TO_STIMULI

RGPD1 RGPD4 RGPD2 NCOR2 RANBP2 NCF2 RGPD8 RGPD3

1.26e-05505328MM15548
PathwayREACTOME_METABOLISM_OF_CARBOHYDRATES

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

2.84e-05271326MM15406
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

3.21e-05277326MM15414
PathwayREACTOME_CELL_CYCLE

RGPD1 CKAP5 RGPD4 RGPD2 RANBP2 HAUS3 RGPD8 RGPD3

4.52e-05603328MM14635
PathwayREACTOME_LOSS_OF_MECP2_BINDING_ABILITY_TO_THE_NCOR_SMRT_COMPLEX

NCOR1 NCOR2

1.04e-047322M27899
PathwayREACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_TO_CONTROL_BILE_ACID_HOMEOSTASIS

NCOR1 NCOR2

1.78e-049322M29809
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

NCOR1 NCOR2 SUV39H2 KAT8 SUV39H1

3.39e-04272325M29619
PathwayREACTOME_LOSS_OF_FUNCTION_OF_MECP2_IN_RETT_SYNDROME

NCOR1 NCOR2

3.83e-0413322M29766
PathwayPID_HDAC_CLASSI_PATHWAY

NCOR1 NCOR2 RANBP2

4.41e-0466323M101
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

NCOR2 SUV39H2 KAT8 SUV39H1

6.29e-04175324MM14941
PathwayREACTOME_RHO_GTPASES_ACTIVATE_NADPH_OXIDASES

NCF2 NOX1

1.34e-0324322M27553
PathwayREACTOME_RHO_GTPASES_ACTIVATE_NADPH_OXIDASES

NCF2 NOX1

1.45e-0325322MM15269
PathwayREACTOME_INFECTION_WITH_MYCOBACTERIUM_TUBERCULOSIS

MRC1 RNF213

1.69e-0327322M29816
PathwayREACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY

NCOR1 NCOR2

1.82e-0328322M6177
PathwayREACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY

NCOR1 NCOR2

2.23e-0331322M669
PathwayREACTOME_METABOLISM_OF_RNA

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

2.25e-03612326MM15547
PathwayREACTOME_REGULATION_OF_MECP2_EXPRESSION_AND_ACTIVITY

NCOR1 NCOR2

2.37e-0332322M27900
PathwayPID_HDAC_CLASSII_PATHWAY

NCOR2 RANBP2

2.68e-0334322M30
PathwayREACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX

NCOR1 NCOR2

3.16e-0337322M29790
PathwayREACTOME_HCMV_EARLY_EVENTS

NCOR1 NCOR2 RANBP2

3.70e-03138323M29805
PathwayKEGG_LYSINE_DEGRADATION

SUV39H2 SUV39H1

4.45e-0344322M13720
PathwayREACTOME_PKMTS_METHYLATE_HISTONE_LYSINES

SUV39H2 SUV39H1

4.85e-0346322MM14933
PathwayREACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING

NCOR1 NCOR2

5.06e-0347322M29777
PathwayPID_HES_HEY_PATHWAY

NCOR1 NCOR2

5.28e-0348322M288
PathwayWP_RETT_SYNDROME

NCOR1 NCOR2

5.28e-0348322M39759
PathwayREACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

NCOR1 NCOR2

5.28e-0348322M611
PathwayREACTOME_HCMV_INFECTION

NCOR1 NCOR2 RANBP2

5.79e-03162323M29804
PathwayREACTOME_RHO_GTPASE_EFFECTORS

CKAP5 RANBP2 NCF2 NOX1

5.86e-03323324M27080
PathwayREACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER

NCOR1 NCOR2

5.94e-0351322M665
PathwayBIOCARTA_PPARA_PATHWAY

NCOR1 NCOR2

6.17e-0352322M2404
PathwayREACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY

NCOR1 NCOR2

6.40e-0353322M8276
PathwayPID_RAC1_PATHWAY

NCF2 NOX1

6.64e-0354322M278
PathwayREACTOME_RAC1_GTPASE_CYCLE

NCF2 NOX1 DOCK9

7.16e-03175323MM15599
PathwayREACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION

MRC1 RNF213 NCF2 ASB14

7.23e-03343324MM15712
PathwayREACTOME_SIGNALING_BY_NOTCH1_PEST_DOMAIN_MUTANTS_IN_CANCER

NCOR1 NCOR2

7.62e-0358322M29616
PathwayPID_NOTCH_PATHWAY

NCOR1 NCOR2

7.88e-0359322M17
PathwayREACTOME_CYTOPROTECTION_BY_HMOX1

NCOR1 NCOR2

8.14e-0360322M41830
PathwayREACTOME_RAC1_GTPASE_CYCLE

NCF2 NOX1 DOCK9

8.22e-03184323M41809
PathwayWP_NOTCH_SIGNALING_WP61

NCOR1 NCOR2

8.40e-0361322M39540
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_MECP2

NCOR1 NCOR2

8.94e-0363322M27862
PathwayPID_ERA_GENOMIC_PATHWAY

NCOR1 NCOR2

9.22e-0364322M200
PathwayREACTOME_INFECTIOUS_DISEASE

MRC1 RNF213 NCOR1 NCOR2 RANBP2 NOX1 P2RX4

9.41e-031081327M27548
PathwayWP_HISTONE_MODIFICATIONS

SUV39H2 SUV39H1

9.50e-0365322M39374
Pubmed

Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

9.29e-18739630944974
Pubmed

Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

9.29e-18739638838144
Pubmed

Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

9.29e-18739621205196
Pubmed

Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

9.29e-18739618949001
Pubmed

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

9.29e-18739625187515
Pubmed

Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

9.29e-1873969037092
Pubmed

Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

9.29e-18739623536549
Pubmed

Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

9.29e-1873968603673
Pubmed

Retina-specifically expressed novel subtypes of bovine cyclophilin.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

9.29e-1873967559465
Pubmed

Complex genomic rearrangements lead to novel primate gene function.

RGPD1 RGPD4 RGPD2 RGPD8 RGPD3 RGPD5

9.29e-18739615710750
Pubmed

Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

9.29e-18739626632511
Pubmed

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

9.29e-18739617372272
Pubmed

Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

9.29e-18739624403063
Pubmed

Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

9.29e-18739623818861
Pubmed

Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

9.29e-18739638657106
Pubmed

Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

9.29e-18739611353387
Pubmed

Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

9.29e-18739612191015
Pubmed

Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

9.29e-18739622821000
Pubmed

Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

9.29e-18739620682751
Pubmed

The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

3.71e-17839622262462
Pubmed

The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

3.71e-17839621670213
Pubmed

Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

3.71e-17839628745977
Pubmed

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

3.71e-17839627412403
Pubmed

Mice lacking Ran binding protein 1 are viable and show male infertility.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

3.71e-17839621310149
Pubmed

The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.11e-1693969733766
Pubmed

Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.11e-16939628100513
Pubmed

Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.11e-16939618394993
Pubmed

Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.11e-16939628877029
Pubmed

The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.11e-16939611553612
Pubmed

Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.11e-16939617887960
Pubmed

The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.11e-16939610601307
Pubmed

The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

2.78e-161039627160050
Pubmed

Parkin ubiquitinates and promotes the degradation of RanBP2.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

2.78e-161039616332688
Pubmed

Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

2.78e-16103968857542
Pubmed

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

2.78e-161039621859863
Pubmed

An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

6.11e-161139635771867
Pubmed

RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

6.11e-161139617069463
Pubmed

T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

6.11e-161139634110283
Pubmed

Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

2.27e-151339631427429
Pubmed

Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

6.60e-151539614697343
Pubmed

Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

9.78e-142239627717094
Pubmed

Peering through the pore: nuclear pore complex structure, assembly, and function.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

3.57e-123839612791264
Pubmed

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.

RGPD1 RGPD4 RGPD2 NCOR1 RANBP2 RGPD8 KAT8 RGPD3

4.38e-1214639823892456
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

RGPD1 CKAP5 TMEM63B RGPD4 TTC27 RGPD2 RANBP2 HAUS3 RGPD8 AZGP1 KAT8 RGPD3 RGPD5 ZFP1

1.28e-111155391420360068
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

RGPD1 CKAP5 RGPD4 TTC27 RGPD2 NCOR1 NCOR2 RANBP2 RGPD8 RGPD3

2.63e-11418391034709266
Pubmed

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

RGPD1 CKAP5 RGPD4 RGPD2 RGPD8 SUGP2 RGPD3 RGPD5

9.77e-1121539835973513
Pubmed

The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

5.85e-108639637253089
Pubmed

Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.38e-099939627746211
Pubmed

Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.

RGPD1 RGPD4 RGPD2 RNF213 RANBP2 NEB RGPD8 DNAJC7 AZGP1 RGPD3 RGPD5

1.45e-09844391125963833
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

RGPD1 RGPD4 RGPD2 NCOR1 RANBP2 SPG11 NEB RGPD8 DNAJC7 LYST PICK1 RGPD3 RGPD5

3.01e-091442391335575683
Pubmed

Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12.

RANBP2 RGPD8 RGPD5

5.21e-0943939480752
Pubmed

Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

8.98e-0913539631077711
Pubmed

Systematic identification of factors for provirus silencing in embryonic stem cells.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.90e-0815339626365490
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

RGPD1 CKAP5 RGPD4 RGPD2 RANBP2 REEP1 RGPD8 SUGP2 DOCK9 FAM177A1 RGPD3

3.20e-081139391136417873
Pubmed

Transcription factor Foxp3 and its protein partners form a complex regulatory network.

RGPD1 CKAP5 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.67e-0737039722922362
Pubmed

Proteomic and yeast 2-hybrid screens to identify PTEN binding partners.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

1.92e-0722639637839992
Pubmed

Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

2.19e-0723139616452087
Pubmed

Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

RGPD1 RGPD4 RGPD2 RANBP2 REEP1 RGPD3 RGPD5

5.53e-0744239715815621
Pubmed

Enzymatic nucleosome acetylation selectively affects activity of histone methyltransferases in vitro.

SUV39H2 KAT8 SUV39H1

5.88e-071539335907431
Pubmed

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.

RGPD1 CKAP5 RGPD4 RGPD2 NCOR2 RANBP2 RGPD8 RGPD3

6.25e-0766539830457570
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

RGPD1 RGPD4 TTC27 RGPD2 NCOR1 RANBP2 RGPD8 DNAJC7 RGPD3 RGPD5

8.96e-071257391037317656
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

RGPD1 CKAP5 RGPD4 RGPD2 NCOR1 NCOR2 RANBP2 RGPD8 RGPD3

9.26e-0796339928671696
Pubmed

Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains.

SUV39H2 SUV39H1

1.23e-06239214690610
Pubmed

Partitioning and plasticity of repressive histone methylation states in mammalian chromatin.

SUV39H2 SUV39H1

1.23e-06239214690609
Pubmed

Aberrant corepressor interactions implicated in PML-RAR(alpha) and PLZF-RAR(alpha) leukemogenesis reflect an altered recruitment and release of specific NCoR and SMRT splice variants.

NCOR1 NCOR2

1.23e-06239221131350
Pubmed

Regulation of corepressor alternative mRNA splicing by hormonal and metabolic signaling.

NCOR1 NCOR2

1.23e-06239226166430
Pubmed

Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways.

NCOR1 NCOR2

1.23e-06239219299558
Pubmed

Unique forms of human and mouse nuclear receptor corepressor SMRT.

NCOR1 NCOR2

1.23e-06239210077563
Pubmed

NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming.

NCOR1 NCOR2

1.23e-06239229531310
Pubmed

Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases.

SUV39H2 SUV39H1

1.23e-06239214702045
Pubmed

Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability.

SUV39H2 SUV39H1

1.23e-06239211701123
Pubmed

Suv39h-catalyzed H3K9me3 is critical for euchromatic genome organization and the maintenance of gene transcription.

SUV39H2 SUV39H1

1.23e-06239238719473
Pubmed

CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.

NCOR1 NCOR2

1.23e-06239227733359
Pubmed

Extreme disruption of heterochromatin is required for accelerated hematopoietic aging.

SUV39H2 SUV39H1

1.23e-06239232305044
Pubmed

Nuclear Receptor Corepressors NCOR1 and SMRT Regulate Metabolism via Intestinal Regulation of Carbohydrate Transport.

NCOR1 NCOR2

1.23e-06239239106294
Pubmed

H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization.

SUV39H2 SUV39H1

1.23e-06239223451023
Pubmed

Suv39h-dependent H3K9me3 marks intact retrotransposons and silences LINE elements in mouse embryonic stem cells.

SUV39H2 SUV39H1

1.23e-06239224981170
Pubmed

Corepressors (NCoR and SMRT) as well as coactivators are recruited to positively regulated 1α,25-dihydroxyvitamin D3-responsive genes.

NCOR1 NCOR2

1.23e-06239222944139
Pubmed

Aberrant levels of SUV39H1 and SUV39H2 methyltransferase are associated with genomic instability in chronic lymphocytic leukemia.

SUV39H2 SUV39H1

1.23e-06239228833505
Pubmed

Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation.

SUV39H2 SUV39H1

1.23e-06239228760199
Pubmed

A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells.

SUV39H2 SUV39H1

1.23e-06239214765126
Pubmed

Evolution of NCoR-1 and NCoR-2 corepressor alternative mRNA splicing in placental mammals.

NCOR1 NCOR2

1.23e-06239231208445
Pubmed

The methyltransferase Suv39h1 links the SUMO pathway to HP1α marking at pericentric heterochromatin.

SUV39H2 SUV39H1

1.23e-06239227426629
Pubmed

Functional interactions with Pit-1 reorganize co-repressor complexes in the living cell nucleus.

NCOR1 NCOR2

3.67e-06339216030140
Pubmed

Nuclear Receptor CoRepressors, NCOR1 and SMRT, are required for maintaining systemic metabolic homeostasis.

NCOR1 NCOR2

3.67e-06339234390859
Pubmed

Genetic examination of SETD7 and SUV39H1/H2 methyltransferases and the risk of diabetes complications in patients with type 1 diabetes.

SUV39H2 SUV39H1

3.67e-06339221896933
Pubmed

Oligomerization of ETO is obligatory for corepressor interaction.

NCOR1 NCOR2

3.67e-06339211113190
Pubmed

Involvement of SMRT corepressor in transcriptional repression by the vitamin D receptor.

NCOR1 NCOR2

3.67e-06339219098224
Pubmed

The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor.

NCOR1 NCOR2

3.67e-06339216373395
Pubmed

Nuclear corepressor SMRT is a strong regulator of body weight independently of its ability to regulate thyroid hormone action.

NCOR1 NCOR2

3.67e-06339231404087
Pubmed

RU486-induced glucocorticoid receptor agonism is controlled by the receptor N terminus and by corepressor binding.

NCOR1 NCOR2

3.67e-06339212011091
Pubmed

EBV nuclear antigen EBNALP dismisses transcription repressors NCoR and RBPJ from enhancers and EBNA2 increases NCoR-deficient RBPJ DNA binding.

NCOR1 NCOR2

3.67e-06339221518914
Pubmed

The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.

SUV39H2 SUV39H1

3.67e-06339228361889
Pubmed

Regulated clearance of histone deacetylase 3 protects independent formation of nuclear receptor corepressor complexes.

NCOR1 NCOR2

3.67e-06339222337871
Pubmed

Cell cycle progression stimulated by tamoxifen-bound estrogen receptor-alpha and promoter-specific effects in breast cancer cells deficient in N-CoR and SMRT.

NCOR1 NCOR2

3.67e-06339215802375
Pubmed

Differential subnuclear localization and replication timing of histone H3 lysine 9 methylation states.

SUV39H2 SUV39H1

3.67e-06339215788566
Pubmed

SMRT and NCoR1 fine-tune inflammatory versus tolerogenic balance in dendritic cells by differentially regulating STAT3 signaling.

NCOR1 NCOR2

3.67e-06339236238311
Pubmed

The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD.

NCOR1 NCOR2

3.67e-06339210406466
Pubmed

Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation.

NCOR1 NCOR2

3.67e-06339236316474
Pubmed

Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo.

NCOR1 NCOR2

3.67e-06339223292142
InteractionRGPD4 interactions

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD5

9.60e-1522397int:RGPD4
InteractionRGPD2 interactions

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD5

4.96e-1427397int:RGPD2
InteractionRGPD3 interactions

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD5

3.42e-1247397int:RGPD3
InteractionRGPD1 interactions

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD5

4.66e-1249397int:RGPD1
InteractionRGPD8 interactions

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD5

9.42e-1174397int:RGPD8
InteractionRGPD5 interactions

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD5

6.05e-1096397int:RGPD5
InteractionNPIPB6 interactions

RGPD1 RANBP2 RGPD8 RGPD5

3.59e-0818394int:NPIPB6
InteractionNPAS1 interactions

NCOR2 HAUS3 SPG11 RGPD8 DNAJC7 EDRF1 RGPD5

3.98e-07245397int:NPAS1
InteractionMCM2 interactions

RGPD1 RGPD4 RGPD2 RNF213 RANBP2 NEB RGPD8 P2RX4 DNAJC7 AZGP1 RGPD3 RGPD5

5.42e-0710813912int:MCM2
InteractionRICTOR interactions

RGPD1 CKAP5 RGPD4 RGPD2 NCOR1 RGPD8 SUGP2 AZGP1 RGPD3 RGPD5

1.28e-067593910int:RICTOR
InteractionRAN interactions

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 DNAJC7 RGPD3 RGPD5

2.91e-06475398int:RAN
InteractionRANBP2 interactions

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3 RGPD5

5.24e-06361397int:RANBP2
InteractionESRP1 interactions

RANBP2 RGPD8 RGPD3 RGPD5

1.46e-0577394int:ESRP1
InteractionINSYN1 interactions

NCOR1 NCOR2 HAUS3 RGPD8 RGPD5

1.79e-05169395int:INSYN1
InteractionNEMP1 interactions

RGPD2 RANBP2 RGPD8 RGPD5

2.60e-0589394int:NEMP1
InteractionFOXL1 interactions

CKAP5 NCOR1 NCOR2 RANBP2 SUGP2

3.64e-05196395int:FOXL1
InteractionRCC1 interactions

RGPD1 RANBP2 RGPD8 RGPD3 RGPD5

4.10e-05201395int:RCC1
InteractionODAD3 interactions

SUV39H2 SUV39H1 RGPD5

7.30e-0542393int:ODAD3
InteractionNR1I2 interactions

NCOR1 NCOR2 DNAJC7

1.09e-0448393int:NR1I2
InteractionZNF276 interactions

CKAP5 NCOR1 PICK1

1.16e-0449393int:ZNF276
InteractionC9orf72 interactions

RGPD1 RGPD4 TTC27 RGPD2 NCOR1 RANBP2 RGPD8 DNAJC7 RGPD3 RGPD5

1.54e-0413193910int:C9orf72
InteractionYWHAZ interactions

CKAP5 NCOR1 TRAPPC11 NEB REEP1 DNAJC7 LYST AZGP1 DOCK9 KAT8

1.54e-0413193910int:YWHAZ
InteractionD2HGDH interactions

HAUS3 SPG11 EDRF1 RGPD5

1.79e-04146394int:D2HGDH
InteractionATXN1L interactions

NCOR1 NCOR2 SUGP2 PICK1

1.98e-04150394int:ATXN1L
InteractionNXF2 interactions

RGPD8 SUGP2 RGPD5

2.69e-0465393int:NXF2
InteractionC8orf74 interactions

SUV39H2 SUV39H1

2.81e-0413392int:C8orf74
InteractionPHF19 interactions

SUV39H2 PICK1 SUV39H1

2.82e-0466393int:PHF19
InteractionNR1H2 interactions

NCOR1 NCOR2 SUV39H1

3.08e-0468393int:NR1H2
InteractionCFAP100 interactions

SUV39H2 SUV39H1

3.27e-0414392int:CFAP100
InteractionRANGAP1 interactions

RGPD1 CKAP5 RGPD2 RANBP2 RGPD5

3.32e-04314395int:RANGAP1
InteractionCAVIN3 interactions

CKAP5 TMEM63B REEP1

3.50e-0471393int:CAVIN3
InteractionCEP63 interactions

RGPD1 NCOR2 HAUS3 RGPD3

3.88e-04179394int:CEP63
InteractionAKIRIN2 interactions

RGPD8 RGPD3 RGPD5

3.95e-0474393int:AKIRIN2
InteractionGUSBP5 interactions

NCOR1 NCOR2 RGPD5

4.11e-0475393int:GUSBP5
InteractionZNF557 interactions

SUV39H2 SUV39H1

5.47e-0418392int:ZNF557
InteractionFBXO22 interactions

NCOR1 NCOR2 SPG11 NEB DNAJC7 DOCK9

5.54e-04540396int:FBXO22
InteractionPGR interactions

NCOR1 NCOR2 DNAJC7

5.73e-0484393int:PGR
InteractionTRAF3IP3 interactions

RANBP2 RGPD8 RGPD5

5.73e-0484393int:TRAF3IP3
Cytoband2p11.2

RGPD1 RGPD2 REEP1

2.28e-05643932p11.2
Cytoband2q13

RGPD8 RGPD3 RGPD5

2.73e-05683932q13
Cytoband2q12.3

RGPD4 RANBP2

9.49e-05173922q12.3
CytobandEnsembl 112 genes in cytogenetic band chr2p11

RGPD1 RGPD2 REEP1

7.96e-04213393chr2p11
CytobandEnsembl 112 genes in cytogenetic band chr2q13

RANBP2 RGPD5

1.17e-0359392chr2q13
CytobandEnsembl 112 genes in cytogenetic band chr2q12

RGPD4 RGPD3

2.24e-0382392chr2q12
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

RGPD1 RGPD4 TTC27 RGPD2 RANBP2 NCF2 RGPD8 DNAJC7 RGPD3 RGPD5

1.96e-151153010769
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

SUV39H2 SUV39H1

1.44e-0334302487
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

NCOR1 NCOR2

3.48e-0353302532
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_B_UP

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

7.80e-1233396MM477
CoexpressionTABULA_MURIS_SENIS_TRACHEA_GRANULOCYTE_AGEING

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 RGPD3

4.25e-1143396MM3857
CoexpressionNAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_CORRELATED_WITH_HAI_28DY_RESPONSE_AT_7DY_NEGATIVE

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 P2RX4 SUGP2 DOCK9 RGPD3 RGPD5

1.35e-094743910M40991
CoexpressionFOSTER_TOLERANT_MACROPHAGE_DN

RGPD1 RGPD4 RGPD2 RANBP2 RGPD8 ADGRL2 RGPD3

3.21e-06435397MM1221
CoexpressionHOUNKPE_HOUSEKEEPING_GENES

RGPD1 RGPD4 RGPD2 RANBP2 SPG11 RGPD8 DNAJC7 KAT8 RGPD3

3.97e-051158399MM1338
CoexpressionMARSON_BOUND_BY_FOXP3_UNSTIMULATED

RGPD1 RGPD4 RGPD2 NCOR1 RANBP2 HAUS3 RGPD8 RGPD3 ZFP1

8.46e-051277399MM1032
CoexpressionGSE13946_CTRL_VS_DSS_COLITIS_GD_TCELL_FROM_COLON_DN

RNF213 P2RX4 ADGRL2 SUV39H1

1.18e-04170394M2942
CoexpressionTORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN

NCF2 KCTD1 CHM ADGRL2 DOCK9

1.19e-04327395M2351
CoexpressionTORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN

NCF2 KCTD1 CHM ADGRL2 DOCK9

1.37e-04337395MM1069
ToppCell5'-Adult-Distal_Rectal-Hematopoietic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 NCF2 HAUS3 NEB

1.56e-05173394b335ca2a247156eba821943b2b9fc9922230b409
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MRC1 RNF213 NCF2 NEB

1.91e-051823944234d0cc57b5266a5e03133c75c7918abe48465e
ToppCellAdult|World / Lineage, Cell type, age group and donor

TMEM63B MRC1 RNF213 NCOR2

2.21e-051893945cd285bfad973125d46d704fec18b21266a63379
ToppCell10x3'2.3-week_14-16-Endothelial|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

MRC1 REEP1 ADGRL2 DOCK9

2.71e-0519939441f046646fff65b7e51b63d3204f76ef32054781
ToppCell10x3'2.3-week_14-16-Endothelial-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

MRC1 REEP1 ADGRL2 DOCK9

2.71e-05199394ef7f7f7c861827574b120f48cf4052c563929081
ToppCell10x5'v1-week_14-16-Endothelial-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

MRC1 REEP1 ADGRL2 DOCK9

2.76e-052003942488aa12970a43a5af352e2c36c73884d73a1cc5
ToppCell10x5'v1-week_14-16-Endothelial|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

MRC1 REEP1 ADGRL2 DOCK9

2.76e-05200394e786544cf6f891550c4be55ebb4928c92297b504
ToppCelldroplet-Heart-HEART-1m-Hematologic-red_blood_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC27 HAUS3 KCTD1

9.46e-051013936c4524be89cf3eb06769c2963dcded3da1e71ca0
ToppCellPND01-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CKAP5 MRC1 SUV39H2

2.59e-04142393be63c48794a227ea55978524c0f5935342fc455e
ToppCellICU-SEP-Lymphocyte-T_NK-Treg|ICU-SEP / Disease, Lineage and Cell Type

RGPD1 KCTD1 RGPD5

2.75e-04145393ee99b58462f955b96d036aa67e343db047d66f64
ToppCellsevere_influenza-Treg|World / disease group, cell group and cell class (v2)

MRC1 RGPD2 SUV39H1

2.98e-041493932a3a00cdf604c8f3f3863df0ddb06938549bf86d
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RGPD1 RGPD2 RGPD3

3.22e-041533937480522a47e367f8facc4f5d599fbaf0b5ad4007
ToppCellsevere_influenza-Treg|severe_influenza / disease group, cell group and cell class (v2)

RGPD2 HAUS3 SUV39H1

3.28e-0415439325f74dfb0f0e014a232bc5318928c478480b178d
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Alveolar_Mac|metastatic_Lymph_Node / Location, Cell class and cell subclass

MRC1 NCF2 P2RX4

3.35e-0415539303fd443740272dcb547e39deaf7ae89b8307f241
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

RGPD1 RGPD2 RGPD3

3.41e-0415639353ded973358e3e48054130131e959f0d1f4ef60f
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8|bone_marrow / Manually curated celltypes from each tissue

RNF213 RANBP2 DOCK9

3.41e-041563931545169694f686d28648a68b552c2ae606599d66
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MRC1 RNF213 NCF2

3.67e-0416039318954241e11309ecb0f3ca87897eadcb20dc8eca
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MRC1 RNF213 NCF2

3.74e-041613935a8698790f9aba796dd2b64af419055c60bd7de8
ToppCelltumor_Lung-Myeloid_cells-Pleural_Mac|tumor_Lung / Location, Cell class and cell subclass

MRC1 NCF2 FER1L5

3.81e-041623939ac3242511315224ed94582aca9e9a3786cd01a0
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MRC1 HAUS3 P2RX4

4.09e-04166393bb8135119dc37fdbba476599a56d368f422688dc
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.1.3|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RGPD2 ASB14 AZGP1

4.16e-041673938fede587572d465cb63f7828141a574185bbb819
ToppCelldroplet-Trachea-3m-Hematologic-myeloid-granulocyte-|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MRC1 NCF2 SUV39H1

4.46e-0417139341932c9e70829ee3d55ca5fdb74d290fc8229416
ToppCellE12.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NOX1 REEP1 DOCK9

4.53e-041723933b9be685fcd1634498a603b692f5ac6ddd0de176
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage|368C / Donor, Lineage, Cell class and subclass (all cells)

MRC1 NCF2 P2RX4

4.61e-04173393bba8265a58f8f5659dc7b9da2fe27b15033fce34
ToppCelltumor_Lymph_Node_/_Brain-T/NK_cells-CD8+/CD4+_Mixed_Th|T/NK_cells / Location, Cell class and cell subclass

MRC1 NEB CHM

4.61e-0417339342c911ed16fabdabef063830e8407192d8bde950
ToppCellPND01-03-samps-Endothelial-Postnatal_endothelial-capillary_endothelial_Hpgd-CA4_high|PND01-03-samps / Age Group, Lineage, Cell class and subclass

REEP1 ADGRL2 DOCK9

4.69e-04174393cb0109661e8c9ca04d67d33f2d926f0e649bf67d
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.5.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MRC1 RNF213 NCF2

4.69e-04174393d5c22b43531414951666ee7542a66ed9380e2d14
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage|343B / Donor, Lineage, Cell class and subclass (all cells)

MRC1 NCF2 RGPD8

4.77e-04175393d3890bd0c570bb81434fdd1c5229891cefe2e462
ToppCellCV-Severe-7|CV / Virus stimulation, Condition and Cluster

RNF213 NCOR2 LYST

4.85e-041763933de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CKAP5 RANBP2 LYST

4.85e-04176393749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellkidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 REEP1 DOCK9

4.93e-04177393227d4f423b00be2e0c5797e2c5275d342e69a0f4
ToppCellkidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 REEP1 DOCK9

4.93e-0417739366ffa279147961080c104242a08b176e301d80e3
ToppCellkidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 REEP1 DOCK9

4.93e-041773930cbf54608d2ba0a0500af142f2029fe5e118c3c2
ToppCellCV-Severe-7|Severe / Virus stimulation, Condition and Cluster

RNF213 NCOR2 LYST

4.93e-0417739382fdd6185b368f54f03de389427cbe3071d21a99
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 NCF2 RGPD3

5.01e-0417839324e8c62060455159235985f456af0c5023a7f3f5
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 NCF2 RGPD3

5.01e-041783934f1cc954d4d9b5b2b75a4cf995ba81e2ada27084
ToppCellPCW_10-12-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

MRC1 REEP1 DOCK9

5.09e-0417939335fe9961e228ce255e3317fc244efa35b5adbf8b
ToppCellPCW_10-12-Endothelial-Endothelial_mature-lymphatic|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

MRC1 REEP1 DOCK9

5.09e-04179393ab3d08b51cd7a37582305615ee221c7a2af83b40
ToppCell368C-Endothelial_cells-Endothelial-E|368C / Donor, Lineage, Cell class and subclass (all cells)

RGPD8 ADGRL2 DOCK9

5.18e-041803938ab16a0b9053bffc07b569a4f9e71749f56dde7e
ToppCell368C-Endothelial_cells-Endothelial-E-|368C / Donor, Lineage, Cell class and subclass (all cells)

RGPD8 ADGRL2 DOCK9

5.18e-04180393394cd465b88429b70eebb2957480dffcbc51cfe7
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MRC1 NCF2 KAT8

5.26e-04181393166ff44fcc0a2943b7f485ea8a9c314964e013bb
ToppCellmild_COVID-19_(asymptomatic)-T/NK_proliferative|World / disease group, cell group and cell class (v2)

RGPD1 NOX1 SUV39H2

5.35e-041823939adf90bb2808f234d53b89ca0ae07380478204ad
ToppCellControl-Endothelial-Endothelial-Activated_Alv_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RNF213 ADGRL2 DOCK9

5.43e-04183393e81c142770f44fd902b0631bc360c5b5339d4c75
ToppCellCV-Healthy-7|CV / Virus stimulation, Condition and Cluster

RGPD8 DOCK9 ZFP1

5.52e-041843930e5cc77aaa73ceb791f8be7456177577fd2e5586
ToppCellCV-Healthy-7|Healthy / Virus stimulation, Condition and Cluster

RGPD8 DOCK9 ZFP1

5.61e-041853931979d189c204f4c2893e3170a514ee7d5523406c
ToppCell368C-Myeloid-Macrophage-FABP4+_Macrophage_3|368C / Donor, Lineage, Cell class and subclass (all cells)

MRC1 NCF2 KAT8

5.69e-04186393ddfadd43efeac3b3e6b7062590cc2b8f2f2db2ab
ToppCell10x3'2.3-week_12-13-Lymphocytic_NK-T_NK-ILC_precursor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

RANBP2 NEB FAM177A1

5.78e-04187393f31d865ce2a21bdf64dbe29ee3e4505ab482604a
ToppCellmetastatic_Brain-Myeloid_cells-Alveolar_Mac|Myeloid_cells / Location, Cell class and cell subclass

MRC1 NCF2 LYST

5.78e-041873937375f70a970a5d5a58b7c33ada2dcf6dcef525c6
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RNF213 ADGRL2 DOCK9

5.78e-04187393f3397dbc23b6c2f24e2c1ba887d8f9aef3ee01a1
ToppCell5'-Adult-Distal_Rectal-Hematopoietic-Myeloid-LYVE1+_Macrophage|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 TRAPPC11 NCF2

5.97e-041893939e3c083174a64ea78648c6d48498fc4e721b569f
ToppCell5'-Adult-Distal_Rectal-Hematopoietic-Myeloid|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 TRAPPC11 NCF2

5.97e-041893936e19bfa52406ebe095daa99f958ec4d596ce6e39
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 REEP1 DOCK9

6.06e-04190393876bd2eb9ed2624cb23bdcf6b989e4fa34d099e3
ToppCellCOVID-19-Heart-EC_3|Heart / Disease (COVID-19 only), tissue and cell type

ADGRL2 LYST DOCK9

6.06e-0419039378e7c502b0450c0b37652b1896a2a752fd8a2111
ToppCellCOVID-19-lung-Vein_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

ADGRL2 LYST DOCK9

6.06e-041903931caeaef78326734c1e31a0c4739190d5c5a77b9e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 REEP1 DOCK9

6.06e-04190393be9f36127028f52ca5fc1b32ba15a6c26aad69ac
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MRC1 REEP1 DOCK9

6.06e-0419039309a8855901c3c9332dbaab3e40166485b696d0f1
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

HAUS3 DOCK9 RGPD5

6.15e-04191393d9a6f61fcda4f5352488f7f55cb9b57aeacc717f
ToppCell10x5'v1-week_12-13-Endothelial-stroma-tip_EC|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

REEP1 ADGRL2 DOCK9

6.15e-04191393cf1a67b7c0d5c0dc5d4d59faf9d9b1a3a1fb00e0
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)

RGPD2 RANBP2 RGPD5

6.15e-041913931ecd9849d14d5ebf3daf610e83fb50820cafd3ed
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

RNF213 LYST EDRF1

6.15e-041913939454f642c3621370fa23640b631301346b300950
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte-Mono_c2-CD14-HLA-DPB1|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

NCOR2 TRAPPC11

6.17e-0442392b0ebd9d2456e4bab44e91b35d728224da6a052ea
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-T_lymphocytic-mature_NK_T_cell|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LYST FAM177A1 RGPD5

6.24e-04192393189477c44040cf0ee16c3932fa49fbd9e3acaa3c
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

RNF213 RANBP2 DOCK9

6.24e-0419239347646d7e4990be85072987f92bf18d52f8da752e
ToppCell5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 REEP1 DOCK9

6.34e-04193393bd0027fa97de41ae22ff64a61c8e217496f122ca
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)-D122|Adult / Lineage, Cell type, age group and donor

MRC1 NCF2 P2RX4

6.34e-04193393cc1b6d3bf56e4a88f6fe23dd036a83cf5538c958
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage_4|343B / Donor, Lineage, Cell class and subclass (all cells)

MRC1 NCF2 KAT8

6.34e-04193393b9dcffd28ca309359fb110fb79de8ce066208ee1
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RGPD1 RNF213 ASB14

6.34e-041933937deb439943d35a4e825674b2b7dcddb45d366ad1
ToppCellnormal_Pleural_Fluid-T/NK_cells-Exhausted_CD8+_T|normal_Pleural_Fluid / Location, Cell class and cell subclass

RNF213 NCOR1 LYST

6.43e-0419439368a9e00c9e1a855eeebfc26c038652f3800758db
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage|367C / Donor, Lineage, Cell class and subclass (all cells)

MRC1 NCF2 KAT8

6.43e-0419439340c91ed945bd5990a0dbf2090d37a660b19aaab2
ToppCell343B-Myeloid-Macrophage|343B / Donor, Lineage, Cell class and subclass (all cells)

MRC1 NCF2 KAT8

6.53e-0419539348ba2044d2459c8b0d17bc7deca8d0195ac6a00e
ToppCelltumor_Lung-Myeloid_cells-Alveolar_Mac|Myeloid_cells / Location, Cell class and cell subclass

MRC1 NCF2 KAT8

6.53e-041953933133591a289c06396cf4705d6a861369e145ac54
ToppCellbackground-Endothelial_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

MRC1 ADGRL2 DOCK9

6.63e-04196393e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCell10x3'2.3-week_14-16-Endothelial-stroma-sinusoidal_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

MRC1 REEP1 ADGRL2

6.73e-04197393f1080d93acf1a4756d2f2c8cabd1fb50bc7bcd09
ToppCell390C-Myeloid-Monocyte-CD16+_Monocyte|390C / Donor, Lineage, Cell class and subclass (all cells)

MRC1 NCF2 P2RX4

6.73e-0419739301f5f5c34e904cc0146e978cc05ed1cd86a41533
ToppCellBL|World / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

RNF213 NCF2 LYST

6.73e-041973931acf0191fa0a25cd20bfd9ea7bf727a1555986a1
ToppCellCOVID-19-lung-Macrophage_LDB2hi_OSMRhi_YAP1hi|COVID-19 / Disease (COVID-19 only), tissue and cell type

MRC1 RNF213 NCF2

6.73e-04197393e42910a653a1b5bd90c090e9665a84871ed2873f
ToppCelltumor_Lung-Endothelial_cells-Lymphatic_ECs|Endothelial_cells / Location, Cell class and cell subclass

MRC1 REEP1 P2RX4

6.73e-04197393a05237ee6d31d9eab491dd7007859d6285cf1424
ToppCellmild-low-quality_cells|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

RNF213 SUGP2 RGPD5

6.73e-04197393e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCellmedial-Hematologic-Interstitial_Macrophage-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MRC1 NCF2 P2RX4

6.73e-04197393b90c8a41e99c87b46be699d03cd49c97a2ad51af
ToppCellnormal_Pleural_Fluid-T/NK_cells-Exhausted_CD8+_T|T/NK_cells / Location, Cell class and cell subclass

RNF213 NCOR1 LYST

6.73e-041973932bf540fa228687a71f595a807e4a2af20588a82c
ToppCellmedial-Hematologic-Interstitial_Macrophage|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MRC1 NCF2 P2RX4

6.73e-0419739313aec816e21754eac590a12c3a9c795c41108277
ToppCellmedial-2-Hematologic-Interstitial_Macrophage|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MRC1 NCF2 P2RX4

6.73e-0419739338a74eeb2a4c8d6a86b133f02f4e6c641f16a3ac
ToppCell10x5'v1-week_12-13-Endothelial|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

REEP1 ADGRL2 DOCK9

6.83e-04198393307dd09e6bc820a148f3000f18dae7aedba4be0b
ToppCelldistal-2-Hematologic-Alveolar_Macrophage|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MRC1 NCF2 P2RX4

6.83e-04198393a8093144cbe3069c25a6c1f1c94218a115da8748
ToppCell5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 REEP1 DOCK9

6.83e-041983935d42f4fda2081ea3e9f62a00e7eea702e0d0be7d
ToppCellmedial-Hematologic-Alveolar_Macrophage-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MRC1 NCF2 P2RX4

6.83e-04198393d64f3d806594619607a72025a93b43ed4efaed01
ToppCelldistal-Hematologic-Alveolar_Macrophage-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MRC1 NCF2 KAT8

6.83e-04198393cd56124ff98a194ec030588dac684535a31cb5e4
ToppCellmedial-Hematologic-Alveolar_Macrophage|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MRC1 NCF2 P2RX4

6.83e-041983938a21f885d26959b349eb4ca027328d6cf0f1b9cf
ToppCellTracheal-10x5prime-Immune_Myeloid-Macrophage_other-Macro_CHIT1|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 NCF2 P2RX4

6.83e-041983939430ce7016b1a4724de036aab3e3e4082d24e436
ToppCelldistal-Hematologic-Alveolar_Macrophage-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MRC1 NCF2 P2RX4

6.83e-04198393e1dc5a56fc23d3b1b4350d7162acec5762115b64
ToppCellBronchus_Control_(B.)-Immune-TX-MoAM-3|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

MRC1 NCF2 P2RX4

6.83e-041983931d92b09aeb03a95fa9e221813002045c4f41dd24
ToppCell10x5'v1-week_12-13-Endothelial-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

REEP1 ADGRL2 DOCK9

6.83e-04198393122215d9288533ad03562cf777e846504863df9a
ToppCell5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 REEP1 DOCK9

6.83e-0419839399d6a64f3410dae3019161feef20a8f06081a24b
ToppCellmedial-2-Hematologic-Alveolar_Macrophage|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MRC1 NCF2 P2RX4

6.83e-04198393ad8b9ac155737f794bf1974c59f8143c6ef63d71
ToppCell367C-Myeloid-Macrophage-SPP1+_Macrophage|367C / Donor, Lineage, Cell class and subclass (all cells)

MRC1 NCF2 P2RX4

6.83e-041983931771c282cd6422c35a4131c827d7daedfd6e7541
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_CCL3+|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MRC1 NCF2 P2RX4

6.83e-041983936b81e74888f9bd004fcfe51f191c6ce7050cdc36
ToppCelldistal-2-Hematologic-Interstitial_Macrophage|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MRC1 NCF2 P2RX4

6.93e-04199393d4caf296b6ce22a10b78d0efd4e018d867ccb78a
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

RNF213 SUGP2 RGPD5

6.93e-04199393f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCelldistal-Hematologic-Interstitial_Macrophage-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MRC1 NCF2 P2RX4

6.93e-04199393e25a67a196f226b60b4aa0ff0cf4471d66333445
ToppCellParenchyma_Control_(B.)-Immune-TX-MoAM-3|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

MRC1 NCF2 P2RX4

6.93e-041993931ce46d9edabb3252f940a5143dd3f2404422d185
Drughalofenate

NCOR1 NCOR2

1.71e-054392CID000033584
DrugPirenperone [ 75444-65-4]; Up 200; 10.2uM; HL60; HT_HG-U133A

NOX1 REEP1 CHM KAT8 PICK1

2.09e-051973952455_UP
Drug0179445-0000 [211246-22-9]; Up 200; 1uM; PC3; HT_HG-U133A

NCOR2 CHM ADGRL2 SUV39H2 EDRF1

2.14e-051983953736_UP
DrugMolsidomine [25717-80-0]; Up 200; 16.6uM; PC3; HT_HG-U133A

NCOR2 NEB CHM ADGRL2 KAT8

2.19e-051993956325_UP
Diseasealcohol and nicotine codependence

RGPD1 RGPD2

1.12e-0413362EFO_0004776
Diseasemultiple myeloma (is_marker_for)

RANBP2 NOX1

8.88e-0436362DOID:9538 (is_marker_for)
DiseaseMoyamoya disease

RNF213 DOCK9

1.10e-0340362MONDO_0016820
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

NCOR1 NCOR2

1.64e-0349362DOID:0060037 (implicated_via_orthology)
Diseaseforced expiratory volume

CKAP5 NCOR1 NCOR2 ADGRL2 DOCK9

2.56e-03789365EFO_0004314
Diseasegut microbiome measurement, bone density

TTC27 ADGRL2

4.10e-0378362EFO_0003923, EFO_0007874
Diseasefree cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement

TTC27 NCOR2 SPG11

5.96e-03303363EFO_0004612, EFO_0020945

Protein segments in the cluster

PeptideGeneStartEntry
EVFESEYSRKKYYYV

ADGRL2

941

O95490
LKAYVLYKEYDLYGQ

ASB14

566

A6NK59
EYKGYEEITFYEYLK

CHM

311

P24386
YFAKLYYEAKEYDLA

RANBP2

31

P49792
YYEAKEYDLAKKYIC

RANBP2

36

P49792
YYREKKYKYVEDYEQ

P2RX4

366

Q99571
YFAKLYYEAKEYDLA

RGPD5

31

Q99666
YYEAKEYDLAKKYIC

RGPD5

36

Q99666
YFAKLYYEAKEYDLA

RGPD8

31

O14715
YYEAKEYDLAKKYIC

RGPD8

36

O14715
FVDAFLKYEKADKYY

NOX1

26

Q9Y5S8
LKYEKADKYYYTRKI

NOX1

31

Q9Y5S8
CVLYYYLTKKNENYK

NCOR2

466

Q9Y618
YYQTEKYDLAIKDLK

NCF2

81

P19878
KYQYAIDEYYRMKKE

FAM177A1

131

Q8N128
EEGLYYNKAIDYYLK

EDRF1

931

Q3B7T1
EYCLKYMKYEKSYRF

KAT8

211

Q9H7Z6
DFKDYTLLYEEAKYF

KCTD1

101

Q719H9
YFAKLYYEAKEYDLA

RGPD3

31

A6NKT7
YYEAKEYDLAKKYIC

RGPD3

36

A6NKT7
AELYEYKKKYSDADI

CKAP5

1851

Q14008
KYAYKAEPYVASEYK

DOCK9

916

Q9BZ29
YNLYYAYLPAKLDKK

TMEM63B

661

Q5T3F8
EFYVYFLKDEDYLKD

HAUS3

571

Q68CZ6
QYKEKEDRYVDTYKY

LYST

3196

Q99698
KKDYNEAYNYYTKAI

DNAJC7

41

Q99615
FYFAKLYYEAKEYDL

RGPD1

21

P0DJD0
LYYEAKEYDLAKKYV

RGPD1

26

P0DJD0
IYKDYQYYFSKEKET

MRC1

806

P22897
YFAKLYYEAKEYDLA

RGPD4

31

Q7Z3J3
YYEAKEYDLAKKYIC

RGPD4

36

Q7Z3J3
LKYKYKDYHTLKVYE

FER1L5

1401

A0AVI2
FAKLYYEAKEYDLAK

RGPD2

31

P0DJD1
LYYYLTKKNENYKAL

NCOR1

476

O75376
YYSYKAVKSKDIKEY

REEP1

21

Q9H902
EYLCDYKKIREQEYY

SUV39H1

46

O43463
EDVYLYYKLAYEHKF

SPG11

2406

Q96JI7
KKHLDKYIPYKYVIY

RNF213

441

Q63HN8
QVPYKYDLYEKTLKY

ZFP1

101

Q6P2D0
EEYYYAKDYTKALKL

TRAPPC11

461

Q7Z392
YLCDYKVVKDMEYYL

SUV39H2

51

Q9H5I1
DENSLEYKYYKLKLA

SUGP2

621

Q8IX01
KYYYDGKDYIEFNKE

AZGP1

136

P25311
FLYYYEYRKAKDQLD

TTC27

241

Q6P3X3
KKYLDVKFEYLSYCL

PICK1

251

Q9NRD5
RDIASDYKYKYNYEK

NEB

2056

P20929
SYFKYKEAYEHTKAY

NEB

4981

P20929