Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	6-phosphofructokinase activity	PFKL PFKM PFKP	8.85e-08	3	90	3	GO:0003872
GeneOntologyMolecularFunction	fructose-6-phosphate binding	PFKL PFKM PFKP	8.80e-07	5	90	3	GO:0070095
GeneOntologyMolecularFunction	phosphofructokinase activity	PFKL PFKM PFKP	3.06e-06	7	90	3	GO:0008443
GeneOntologyMolecularFunction	AMP binding	PFKL PFKM PFKP	1.11e-04	21	90	3	GO:0016208
GeneOntologyMolecularFunction	carbohydrate kinase activity	PFKL PFKM PFKP	1.11e-04	21	90	3	GO:0019200
GeneOntologyMolecularFunction	fructose binding	PFKL PFKM	2.98e-04	6	90	2	GO:0070061
GeneOntologyMolecularFunction	extracellularly glutamate-gated ion channel activity	GRIN2A SLC1A7	4.16e-04	7	90	2	GO:0005234
GeneOntologyMolecularFunction	snoRNA binding	NUDT5 DKC1 DDX21	4.79e-04	34	90	3	GO:0030515
GeneOntologyMolecularFunction	chloride channel activity	CLCN2 CLCN6 SLC1A7 GABRA3	6.18e-04	86	90	4	GO:0005254
GeneOntologyMolecularFunction	monosaccharide binding	DBH PFKL PFKM PFKP	8.99e-04	95	90	4	GO:0048029
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	CAD NUDT5 RPS6KA5 NTRK2 DKC1 PFKL PFKM PFKP MAP4K2 RPS6KL1 PDXK POLR3A	1.01e-03	938	90	12	GO:0016772
GeneOntologyMolecularFunction	voltage-gated chloride channel activity	CLCN2 CLCN6	1.08e-03	11	90	2	GO:0005247
GeneOntologyMolecularFunction	monoatomic anion channel activity	CLCN2 CLCN6 SLC1A7 GABRA3	1.21e-03	103	90	4	GO:0005253
GeneOntologyMolecularFunction	metal-dependent deubiquitinase activity	PRPF8 MYSM1	1.29e-03	12	90	2	GO:0140492
GeneOntologyBiologicalProcess	fructose 1,6-bisphosphate metabolic process	PFKL PFKM PFKP	6.85e-06	9	91	3	GO:0030388
GeneOntologyBiologicalProcess	nuclear-transcribed mRNA catabolic process	UPF2 EIF4A3 CNOT10 RC3H1 MLH1 EXOSC2	2.62e-05	132	91	6	GO:0000956
GeneOntologyBiologicalProcess	NADH metabolic process	IDH3A PFKL PFKM PFKP	3.49e-05	42	91	4	GO:0006734
GeneOntologyBiologicalProcess	fructose 6-phosphate metabolic process	PFKL PFKM PFKP	4.46e-05	16	91	3	GO:0006002
GeneOntologyBiologicalProcess	nucleobase-containing compound catabolic process	NUDT5 UPF2 EIF4A3 CNOT10 RC3H1 MLH1 DKC1 FASTKD5 PFKL PFKM PFKP EXOSC2	5.46e-05	696	91	12	GO:0034655
GeneOntologyBiologicalProcess	NADH regeneration	PFKL PFKM PFKP	1.04e-04	21	91	3	GO:0006735
GeneOntologyBiologicalProcess	canonical glycolysis	PFKL PFKM PFKP	1.04e-04	21	91	3	GO:0061621
GeneOntologyBiologicalProcess	glucose catabolic process to pyruvate	PFKL PFKM PFKP	1.04e-04	21	91	3	GO:0061718
GeneOntologyBiologicalProcess	monosaccharide catabolic process	NUDT5 PFKL PFKM PFKP	1.17e-04	57	91	4	GO:0046365
GeneOntologyBiologicalProcess	NAD catabolic process	PFKL PFKM PFKP	1.78e-04	25	91	3	GO:0019677
GeneOntologyBiologicalProcess	glycolytic process through glucose-6-phosphate	PFKL PFKM PFKP	1.78e-04	25	91	3	GO:0061620
GeneOntologyBiologicalProcess	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	CNOT10 RC3H1 MLH1 EXOSC2	1.95e-04	65	91	4	GO:0000288
GeneOntologyBiologicalProcess	NAD metabolic process	IDH3A PFKL PFKM PFKP	3.39e-04	75	91	4	GO:0019674
GeneOntologyBiologicalProcess	glycolytic process through fructose-6-phosphate	PFKL PFKM PFKP	3.41e-04	31	91	3	GO:0061615
GeneOntologyBiologicalProcess	double-strand break repair via nonhomologous end joining	SMCHD1 MLH1 TFIP11 TOP2B	3.75e-04	77	91	4	GO:0006303
GeneOntologyBiologicalProcess	regulation of double-strand break repair via nonhomologous end joining	SMCHD1 TFIP11 TOP2B	3.76e-04	32	91	3	GO:2001032
GeneOntologyBiologicalProcess	glucose catabolic process	PFKL PFKM PFKP	3.76e-04	32	91	3	GO:0006007
GeneOntologyBiologicalProcess	positive regulation of peptidyl-lysine acetylation	DIP2B DIP2A	3.99e-04	7	91	2	GO:2000758
GeneOntologyBiologicalProcess	peripheral nervous system axon ensheathment	SH3TC2 NTRK2 ITGB4	4.12e-04	33	91	3	GO:0032292
GeneOntologyBiologicalProcess	myelination in peripheral nervous system	SH3TC2 NTRK2 ITGB4	4.12e-04	33	91	3	GO:0022011
GeneOntologyBiologicalProcess	ribonucleoside diphosphate metabolic process	CAD NUDT5 PFKL PFKM PFKP	4.30e-04	143	91	5	GO:0009185
GeneOntologyCellularComponent	6-phosphofructokinase complex	PFKL PFKM PFKP	7.98e-08	3	91	3	GO:0005945
GeneOntologyCellularComponent	terminal bouton	CAD TNN NTRK2 DBH GRIN2A SLC1A7	3.90e-06	96	91	6	GO:0043195
GeneOntologyCellularComponent	axon terminus	CAD KCNC3 TNN NTRK2 DBH GRIN2A SLC1A7	3.70e-05	210	91	7	GO:0043679
GeneOntologyCellularComponent	neuron projection terminus	CAD KCNC3 TNN NTRK2 DBH GRIN2A SLC1A7	7.14e-05	233	91	7	GO:0044306
GeneOntologyCellularComponent	distal axon	CAD KCNC3 TNN NTRK2 LRP1 DBH GRIN2A PCDH9 SLC1A7	1.17e-04	435	91	9	GO:0150034
GeneOntologyCellularComponent	dendrite	DIP2B DIP2A CLCN2 KCNC3 EIF4A3 TNN NTRK2 LRP1 MPDZ DBH GRIN2A GABRA3	3.39e-04	858	91	12	GO:0030425
GeneOntologyCellularComponent	dendritic tree	DIP2B DIP2A CLCN2 KCNC3 EIF4A3 TNN NTRK2 LRP1 MPDZ DBH GRIN2A GABRA3	3.46e-04	860	91	12	GO:0097447
GeneOntologyCellularComponent	neuron projection membrane	KCNC3 GRIN2A ADGRV1 GABRA3	4.54e-04	82	91	4	GO:0032589
GeneOntologyCellularComponent	axon	DIP2B CAD KCNC3 MYCBP2 TNN NTRK2 LRP1 DBH GRIN2A TNFRSF21 PCDH9 SLC1A7	4.76e-04	891	91	12	GO:0030424
GeneOntologyCellularComponent	NSL complex	PHF20L1 KAT8	1.00e-03	11	91	2	GO:0044545
GeneOntologyCellularComponent	U2-type catalytic step 1 spliceosome	EIF4A3 PRPF8	1.65e-03	14	91	2	GO:0071006
GeneOntologyCellularComponent	catalytic step 1 spliceosome	EIF4A3 PRPF8	1.65e-03	14	91	2	GO:0071012
GeneOntologyCellularComponent	dendrite membrane	KCNC3 GRIN2A GABRA3	1.87e-03	56	91	3	GO:0032590
GeneOntologyCellularComponent	postsynaptic membrane	KCNC3 NTRK2 LRP1 GRIN2A ITGB4 SLC1A7 GABRA3	1.95e-03	405	91	7	GO:0045211
Domain	6-Pfructokinase_euk	PFKL PFKM PFKP	1.12e-07	3	91	3	IPR009161
Domain	PHOSPHOFRUCTOKINASE	PFKL PFKM PFKP	1.12e-07	3	91	3	PS00433
Domain	Phosphofructokinase_CS	PFKL PFKM PFKP	1.12e-07	3	91	3	IPR015912
Domain	PFK	PFKL PFKM PFKP	1.12e-07	3	91	3	PF00365
Domain	ATP_PFK	PFKL PFKM PFKP	1.12e-07	3	91	3	IPR022953
Domain	Phosphofructokinase_dom	PFKL PFKM PFKP	1.12e-07	3	91	3	IPR000023
Domain	DMAP_binding	DIP2B DIP2A DIP2C	1.11e-06	5	91	3	PF06464
Domain	DMAP1-bd	DIP2B DIP2A DIP2C	2.21e-06	6	91	3	IPR010506
Domain	DMAP_binding	DIP2B DIP2A DIP2C	2.21e-06	6	91	3	SM01137
Domain	SUI1_euk	EIF1B EIF1	2.35e-05	2	91	2	IPR005874
Domain	DUF5050	LRP1 LRP1B	2.35e-05	2	91	2	IPR032485
Domain	DUF5050	LRP1 LRP1B	2.35e-05	2	91	2	PF16472
Domain	-	SMCHD1 MLH1 TOP2B	1.20e-04	20	91	3	3.30.565.10
Domain	HATPase_C	SMCHD1 MLH1 TOP2B	1.40e-04	21	91	3	IPR003594
Domain	-	EIF1B EIF1	1.40e-04	4	91	2	3.30.780.10
Domain	SUI1	EIF1B EIF1	1.40e-04	4	91	2	PF01253
Domain	SUI1	EIF1B EIF1	1.40e-04	4	91	2	PS50296
Domain	SUI1	EIF1B EIF1	2.33e-04	5	91	2	IPR001950
Domain	AMP-binding	DIP2B DIP2A DIP2C	4.13e-04	30	91	3	PF00501
Domain	AMP-dep_Synth/Lig	DIP2B DIP2A DIP2C	4.13e-04	30	91	3	IPR000873
Domain	Calx_beta	ADGRV1 ITGB4	6.45e-04	8	91	2	SM00237
Domain	Calx_beta	ADGRV1 ITGB4	8.27e-04	9	91	2	IPR003644
Domain	Cl-channel_core	CLCN2 CLCN6	8.27e-04	9	91	2	IPR014743
Domain	-	CLCN2 CLCN6	8.27e-04	9	91	2	1.10.3080.10
Domain	Voltage_CLC	CLCN2 CLCN6	8.27e-04	9	91	2	PF00654
Domain	Cl-channel_volt-gated	CLCN2 CLCN6	8.27e-04	9	91	2	IPR001807
Domain	Calx-beta	ADGRV1 ITGB4	8.27e-04	9	91	2	PF03160
Domain	JAMM/MPN+_dom	PRPF8 MYSM1	1.50e-03	12	91	2	IPR000555
Domain	JAB_MPN	PRPF8 MYSM1	1.50e-03	12	91	2	SM00232
Domain	JAB	PRPF8 MYSM1	1.50e-03	12	91	2	PF01398
Domain	WD40	WIPI1 NBEAL1 DNAAF10 COPB2 ELP2 DCAF4L1	1.67e-03	259	91	6	PF00400
Domain	WD40	WIPI1 NBEAL1 DNAAF10 COPB2 ELP2 DCAF4L1	1.99e-03	268	91	6	SM00320
Domain	Ldl_recept_b	LRP1 LRP1B	2.06e-03	14	91	2	PF00058
Domain	LDLRB	LRP1 LRP1B	2.06e-03	14	91	2	PS51120
Domain	WD40_repeat	WIPI1 NBEAL1 DNAAF10 COPB2 ELP2 DCAF4L1	2.14e-03	272	91	6	IPR001680
Domain	LY	LRP1 LRP1B	2.37e-03	15	91	2	SM00135
Domain	LDLR_classB_rpt	LRP1 LRP1B	2.37e-03	15	91	2	IPR000033
Domain	WD_REPEATS_1	WIPI1 NBEAL1 DNAAF10 COPB2 ELP2 DCAF4L1	2.39e-03	278	91	6	PS00678
Domain	WD_REPEATS_2	WIPI1 NBEAL1 DNAAF10 COPB2 ELP2 DCAF4L1	2.43e-03	279	91	6	PS50082
Domain	WD_REPEATS_REGION	WIPI1 NBEAL1 DNAAF10 COPB2 ELP2 DCAF4L1	2.43e-03	279	91	6	PS50294
Domain	CBS	CLCN2 CLCN6	2.70e-03	16	91	2	SM00116
Domain	EGF_extracell	TNN LRP1B ITGB4	3.13e-03	60	91	3	IPR013111
Domain	EGF_2	TNN LRP1B ITGB4	3.13e-03	60	91	3	PF07974
Domain	WD40_repeat_dom	WIPI1 NBEAL1 DNAAF10 COPB2 ELP2 DCAF4L1	3.31e-03	297	91	6	IPR017986
Domain	HATPase_c	MLH1 TOP2B	3.41e-03	18	91	2	SM00387
Domain	Fibrinogen_CS	ANGPTL6 TNN	3.80e-03	19	91	2	IPR020837
Domain	HATPase_c	MLH1 TOP2B	3.80e-03	19	91	2	PF02518
Domain	CBS_dom	CLCN2 CLCN6	4.21e-03	20	91	2	IPR000644
Domain	CBS	CLCN2 CLCN6	4.21e-03	20	91	2	PF00571
Domain	CBS	CLCN2 CLCN6	4.21e-03	20	91	2	PS51371
Domain	-	MLH1 TOP2B	4.64e-03	21	91	2	3.30.230.10
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	CAD UPF2 MYCBP2 EIF4A3 SMCHD1 COPB2 MLH1 DKC1 TFIP11 PFKL PFKM PFKP PRPF8 QARS1 DDX21 TOP2B TUFM POLR3A	1.70e-08	1353	93	18	29467282
Pubmed	Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches.	PFKL PFKM PFKP	1.85e-08	3	93	3	33141153
Pubmed	Phosphofructokinase (PFK) isozymes in man. I. Studies of adult human tissues.	PFKL PFKM PFKP	1.85e-08	3	93	3	156693
Pubmed	Functional expression of human mutant phosphofructokinase in yeast: genetic defects in French Canadian and Swiss patients with phosphofructokinase deficiency.	PFKL PFKM PFKP	1.85e-08	3	93	3	7825568
Pubmed	Isozymes of human phosphofructokinase in blood cells and cultured cell lines: molecular and genetic evidence for a trigenic system.	PFKL PFKM PFKP	1.85e-08	3	93	3	6451249
Pubmed	Isozymes of human phosphofructokinase: identification and subunit structural characterization of a new system.	PFKL PFKM PFKP	1.85e-08	3	93	3	6444721
Pubmed	Genomic organization, 5'flanking region and tissue-specific expression of mouse phosphofructokinase C gene.	PFKL PFKM PFKP	1.85e-08	3	93	3	11137296
Pubmed	CGG-repeat expansion in the DIP2B gene is associated with the fragile site FRA12A on chromosome 12q13.1.	DIP2B DIP2A DIP2C	1.85e-08	3	93	3	17236128
Pubmed	Characterization of the enzymatic defect in late-onset muscle phosphofructokinase deficiency. New subtype of glycogen storage disease type VII.	PFKL PFKM PFKP	1.85e-08	3	93	3	2960695
Pubmed	Phosphofructokinase isozyme expression during myoblast differentiation.	PFKL PFKM PFKP	1.85e-08	3	93	3	2521854
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	CMBL CAD DNAAF10 EIF4A3 SMCHD1 COPB2 DKC1 TFIP11 AHCYL2 PFKL PFKM PFKP PRPF8 QARS1 DDX21 EXOSC2 TOP2B TUFM	3.37e-08	1415	93	18	28515276
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	CAD MYCBP2 EIF4A3 COPB2 DKC1 FASTKD5 ELP2 PFKL PFKM PFKP PRPF8 QARS1 DDX21 EXOSC2 TUFM PDXK POLR3A	3.55e-08	1257	93	17	37317656
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	CAD MYCBP2 EIF4A3 CNOT10 SMCHD1 RC3H1 PRPF8 QARS1 RNF17 TOP2B	4.46e-08	358	93	10	32460013
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	NUDT5 UPF2 MYCBP2 CNOT10 RC3H1 COPB2 DKC1 PFKL PRPF8 QARS1 DDX21 EXOSC2 TOP2B	6.98e-08	724	93	13	36232890
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	CAD EIF4A3 SMCHD1 COPB2 LRP1 FASTKD5 PFKL PFKM PFKP PRPF8 DDX21 TUFM	9.18e-08	613	93	12	22268729
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	SMCHD1 DKC1 PFKL PRPF8 DDX21 EXOSC2 TOP2B TUFM PCNT	3.43e-07	340	93	9	29478914
Pubmed	Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.	CAD KAT8 COPB2 DKC1 PRPF8 QARS1 DDX21 EXOSC2 TUFM POLR3A	4.00e-07	454	93	10	33226137
Pubmed	Defining the membrane proteome of NK cells.	DIP2B CAD MYCBP2 EIF4A3 CNOT10 MFSD6 MLH1 PFKL PFKP PRPF8 DDX21 TUFM ALG2 POLR3A PCNT	4.80e-07	1168	93	15	19946888
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	TFCP2L1 CAD EIF4A3 SMCHD1 KAT8 COPB2 DKC1 PFKP PRPF8 EXOSC2 TOP2B TUFM PDXK POLR3A	5.12e-07	1014	93	14	32416067
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	CAD MYCBP2 EIF4A3 SMCHD1 DKC1 IDH3A PFKL PFKP PRPF8 QARS1 DDX21 TOP2B TUFM PCNT	5.76e-07	1024	93	14	24711643
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	CAD UPF2 DKC1 FASTKD5 PFKP PRPF8 DDX21 EXOSC2 TUFM PCNT	7.43e-07	486	93	10	30940648
Pubmed	Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex.	CAD PFKL PFKP DDX21 TUFM	8.25e-07	64	93	5	22865885
Pubmed	Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin.	DIP2B DIP2A DIP2C GRIN2A	9.34e-07	28	93	4	31600191
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	CAD EIF4A3 SMCHD1 COPB2 DKC1 FASTKD5 IDH3A PFKL PFKM PRPF8 QARS1 DDX21 TOP2B TUFM PDXK POLR3A	1.13e-06	1425	93	16	30948266
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	CAD SMCHD1 FRYL PRPF8 ITGB4 TOP2B TUFM	1.25e-06	202	93	7	33005030
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	CAD UPF2 MYCBP2 SMCHD1 PKHD1 PRPF8 DDX21	1.25e-06	202	93	7	24639526
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	PHF20L1 EIF4A3 TNN SMCHD1 PKHD1 DKC1 AHCYL2 PFKM PFKP PRPF8 RNF17 DDX21 TOP2B TUFM ALG2 PCNT	1.31e-06	1442	93	16	35575683
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DIP2B DIP2A UPF2 MLH1 MPDZ TFIP11 ELP2 PFKL TUFM POLR3A SH3BP4	1.36e-06	650	93	11	38777146
Pubmed	Genome-wide association study of smoking initiation and current smoking.	NTRK2 CDH23 GRIN2A	1.54e-06	9	93	3	19268276
Pubmed	Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.	CAD EIF4A3 RC3H1 DKC1 MPDZ PRPF8 DDX21	2.20e-06	220	93	7	24550385
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	CAD NUDT5 MYCBP2 DNAAF10 COPB2 MPDZ IDH3A PFKL PFKP EIF1 PRPF8 QARS1 EXOSC2 TUFM	2.23e-06	1149	93	14	35446349
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	EIF4A3 SMCHD1 COPB2 MLH1 PFKM PFKP PRPF8 RNF17 DDX21 PCNT	3.71e-06	582	93	10	20467437
Pubmed	Characterization of staufen1 ribonucleoproteins by mass spectrometry and biochemical analyses reveal the presence of diverse host proteins associated with human immunodeficiency virus type 1.	CAD EIF4A3 IDH3A PFKL PRPF8 QARS1 DDX21	4.01e-06	241	93	7	23125841
Pubmed	High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.	CMBL EIF4A3 RC3H1 COPB2 DKC1 QARS1 DDX21 EXOSC2 TUFM	4.83e-06	469	93	9	37314180
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	CAD EIF4A3 COPB2 MLH1 TFIP11 PFKL PFKM PFKP PRPF8 QARS1 DDX21 EXOSC2 TUFM SH3BP4	5.70e-06	1247	93	14	27684187
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	UPF2 MYCBP2 EIF4A3 SMCHD1 COPB2 DKC1 PRPF8 QARS1 DDX21 EXOSC2 TOP2B	5.98e-06	759	93	11	35915203
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DIP2B CAD UPF2 MYCBP2 EIF4A3 COPB2 DKC1 TFIP11 PRPF8 DDX21 EXOSC2 TOP2B TUFM	6.18e-06	1082	93	13	38697112
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	CAD COPB2 DKC1 FASTKD5 PFKL PFKM PFKP EIF1 PRPF8 QARS1 EXOSC2 TOP2B TUFM PDXK POLR3A	6.28e-06	1440	93	15	30833792
Pubmed	Striking differences of LDL receptor-related protein 1B expression in mouse and human.	LRP1 LRP1B	7.07e-06	2	93	2	15963947
Pubmed	Insulin specifically regulates expression of liver and muscle phosphofructokinase isoforms.	PFKL PFKM	7.07e-06	2	93	2	29655163
Pubmed	Vlgr1 knockout mice show audiogenic seizure susceptibility.	DBH ADGRV1	7.07e-06	2	93	2	15606908
Pubmed	Cloning, genomic organization and expression pattern of a novel Drosophila gene, the disco-interacting protein 2 (dip2), and its murine homolog.	DIP2A DIP2C	7.07e-06	2	93	2	12137943
Pubmed	Cloning of human muscle phosphofructokinase cDNA.	PFKM PFKP	7.07e-06	2	93	2	2822475
Pubmed	Isozyme analysis of human polymorphonuclear leukocyte phosphofructokinase from insulin resistant individuals.	PFKL PFKM	7.07e-06	2	93	2	8780720
Pubmed	The molecular mechanism of the inherited phosphofructokinase deficiency associated with hemolysis and myopathy.	PFKL PFKM	7.07e-06	2	93	2	6444532
Pubmed	The glycolytic enzyme phosphofructokinase-1 assembles into filaments.	PFKL PFKM	7.07e-06	2	93	2	28646105
Pubmed	Chimeric phosphofructokinases involving exchange of the N- and C-terminal halves of mammalian isozymes: implications for ligand binding sites.	PFKM PFKP	7.07e-06	2	93	2	17544406
Pubmed	Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations.	PFKM PFKP	7.07e-06	2	93	2	25985179
Pubmed	Expressed sequence tags identify a human isolog of the suil translation initiation factor.	EIF1B EIF1	7.07e-06	2	93	2	7904817
Pubmed	The Mass1frings mutation underlies early onset hearing impairment in BUB/BnJ mice, a model for the auditory pathology of Usher syndrome IIC.	CDH23 ADGRV1	7.07e-06	2	93	2	15820310
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	NUDT5 SMCHD1 MLH1 DKC1 TFIP11 PFKL PFKM PFKP PRPF8 DDX21 TOP2B PCNT	7.43e-06	934	93	12	33916271
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	NTRK2 LRP1 ADGRV1 LRP1B ITGB4	7.93e-06	101	93	5	23382219
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	CAD EIF4A3 COPB2 DKC1 IDH3A PRPF8 QARS1 DDX21 TOP2B TUFM	8.29e-06	638	93	10	33239621
Pubmed	Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.	CAD EIF4A3 COPB2 DKC1 PFKM PRPF8 QARS1 DDX21 TOP2B TUFM	8.63e-06	641	93	10	36057605
Pubmed	Repression of rRNA transcription by PARIS contributes to Parkinson's disease.	CAD COPB2 PFKL PFKM PRPF8 DDX21 TUFM	8.85e-06	272	93	7	25315684
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DIP2A CAD MYCBP2 MPDZ FASTKD5 TFIP11 ELP2 PFKM PFKP PRPF8 DDX21 TOP2B C2CD5 PCNT SH3BP4	9.21e-06	1487	93	15	33957083
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	PFKL PFKM PFKP PRPF8 ITGB4 TUFM	9.88e-06	182	93	6	32239614
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	DIP2B DIP2A CAD UPF2 MYCBP2 DNAAF10 DKC1 FASTKD5 AHCYL2 IDH3A PFKM DDX21 TUFM POLR3A PCNT	9.90e-06	1496	93	15	32877691
Pubmed	Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.	CAD SMCHD1 PFKM DDX21 TOP2B	1.00e-05	106	93	5	19394292
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	CAD MYCBP2 SMCHD1 COPB2 FRYL PFKP PRPF8 DDX21 TUFM PCNT	1.01e-05	653	93	10	22586326
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	CAD UPF2 EIF4A3 SMCHD1 DKC1 FASTKD5 TFIP11 IDH3A PFKL PRPF8 QARS1 DDX21 TOP2B TUFM	1.07e-05	1318	93	14	30463901
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	CAD UPF2 EIF4A3 EIF1B SMCHD1 COPB2 LRP1 PRPF8 QARS1 DDX21 EXOSC2 TUFM	1.10e-05	971	93	12	33306668
Pubmed	Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer.	DKC1 PRPF8 DDX21 TOP2B	1.18e-05	52	93	4	24591637
Pubmed	MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial and ciliary functions by controlling gene promoters.	KAT8 ITGB4 PCNT	1.22e-05	17	93	3	37479688
Pubmed	Rewiring of embryonic glucose metabolism via suppression of PFK-1 and aldolase during mouse chorioallantoic branching.	PFKL PFKM PFKP	1.47e-05	18	93	3	28049690
Pubmed	Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry.	EIF1B MLH1 PFKL PFKP EIF1 QARS1 DDX21 TUFM	1.51e-05	411	93	8	36652389
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	MYCBP2 CNOT10 LRP1 DKC1 MPDZ AHCYL2 IDH3A PFKL PFKP PRPF8 FEM1A POLR3A	1.54e-05	1005	93	12	19615732
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	NUDT5 UPF2 EIF4A3 IDH3A PFKM PFKP PRPF8 QARS1 DDX21 POLR3A PCNT	1.66e-05	847	93	11	35235311
Pubmed	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	NTRK2 TFIP11 DBH GRIN2A SLC1A7 PDXK GABRA3	1.67e-05	300	93	7	19086053
Pubmed	RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.	CAD DKC1 TFIP11 PFKP PRPF8 QARS1 DDX21 TUFM	1.92e-05	425	93	8	21081503
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	CAD UPF2 EIF4A3 COPB2 ELP2 PFKP PRPF8 TOP2B TUFM POLR3A	1.93e-05	704	93	10	29955894
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	EIF4A3 SMCHD1 COPB2 DKC1 FASTKD5 IDH3A PFKL PRPF8 DDX21 TUFM	2.10e-05	711	93	10	33022573
Pubmed	p53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP.	CMBL PFKP	2.12e-05	3	93	2	37967006
Pubmed	Ontogeny of CLCN3 chloride channel gene expression in human pulmonary epithelium.	CLCN2 CLCN6	2.12e-05	3	93	2	11306429
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	DIP2A CAD CLCN6 UPF2 COPB2 RBP3 GRIN2A IDH3A PFKL PFKM PFKP TUFM ALG2 PDXK	2.65e-05	1431	93	14	37142655
Pubmed	PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation.	CAD SMCHD1 PRPF8 DDX21 EXOSC2 TUFM	2.67e-05	217	93	6	31685992
Pubmed	Genetical genomic determinants of alcohol consumption in rats and humans.	NTRK2 MPDZ DBH GRIN2A GABRA3	2.70e-05	130	93	5	19874574
Pubmed	Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders.	EOMES GRIN2A GABRA3	2.75e-05	22	93	3	35245678
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	CAD COPB2 AHCYL2 PFKM PFKP QARS1 DDX21 TUFM	2.92e-05	451	93	8	36168627
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	DIP2B SMCHD1 COPB2 PFKL PFKM PFKP PRPF8	3.18e-05	332	93	7	32786267
Pubmed	An analysis of expression patterns of genes encoding proteins with catalytic activities.	IDH3A PFKL PFKM PFKP	3.23e-05	67	93	4	17626619
Pubmed	Interaction of protocadherin-15 with the scaffold protein whirlin supports its anchoring of hair-bundle lateral links in cochlear hair cells.	CDH23 ADGRV1	4.23e-05	4	93	2	33009420
Pubmed	Centrosomal microtubule nucleation regulates radial migration of projection neurons independently of polarization in the developing brain.	EOMES PCNT	4.23e-05	4	93	2	36796357
Pubmed	Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes.	UPF2 EIF1	4.23e-05	4	93	2	11073994
Pubmed	Novel key roles for structural maintenance of chromosome flexible domain containing 1 (Smchd1) during preimplantation mouse development.	EOMES SMCHD1	4.23e-05	4	93	2	29900695
Pubmed	Treatment response to low-dose ketamine infusion for treatment-resistant depression: A gene-based genome-wide association study.	NTRK2 GRIN2A	4.23e-05	4	93	2	33370585
Pubmed	Role for a novel Usher protein complex in hair cell synaptic maturation.	CDH23 ADGRV1	4.23e-05	4	93	2	22363448
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	DIP2B RPS6KA5 MYCBP2 DKC1 TFIP11 PFKP DDX21 EXOSC2 TOP2B C2CD5	4.31e-05	774	93	10	15302935
Pubmed	Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.	CAD COPB2 PFKP PRPF8 DDX21	4.40e-05	144	93	5	35681168
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	SLC9C1 CEP120 NUDT5 MYCBP2 DNAAF10 CNOT10 CDH23 PFKP PRPF8 QARS1 EXOSC2 PCDH9 SH3BP4	4.98e-05	1321	93	13	27173435
Pubmed	CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination.	EOMES MLH1 PCNT	5.17e-05	27	93	3	26158450
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	UPF2 EIF4A3 CNOT10 DKC1 PFKM MYSM1 TOP2B	5.69e-05	364	93	7	24778252
Pubmed	EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.	CAD ACADS EIF4A3 PFKL PFKM PFKP PRPF8 QARS1 DDX21 TUFM	5.85e-05	803	93	10	36517590
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	CEP120 NUDT5 PHF20L1 EIF4A3 CNOT10 KAT8 COPB2 DKC1 TFIP11 PRPF8 DDX21 TOP2B	5.95e-05	1155	93	12	20360068
Pubmed	LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.	EIF4A3 PFKM PFKP DDX21	6.17e-05	79	93	4	26446488
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	CAD MYCBP2 EIF4A3 SMCHD1 EIF1 PRPF8 QARS1 DDX21 EXOSC2 TUFM	6.23e-05	809	93	10	32129710
Pubmed	Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.	CMBL CAD SMCHD1 PRPF8 DDX21 TUFM	6.69e-05	256	93	6	32698014
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	ANGPTL6 TNN NTRK2 LRP1 DBH ITGB4	6.84e-05	257	93	6	16335952
Pubmed	Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.	CAD EIF4A3 COPB2 PRPF8 QARS1 TUFM	6.99e-05	258	93	6	21081666
Pubmed	Human immunodeficiency virus-1 Tat protein increases the number of inhibitory synapses between hippocampal neurons in culture.	LRP1 GRIN2A	7.04e-05	5	93	2	24198379
Interaction	PTGES3 interactions	DIP2B DIP2A CAD RPS6KA5 DNAAF10 CNOT10 KAT8 DKC1 PRPF8 TOP2B POLR3A	4.38e-06	437	91	11	int:PTGES3
Interaction	ATG3 interactions	KAT8 COPB2 GPR141 DKC1 TFIP11 QARS1 DDX21 EXOSC2 POLR3A	5.21e-06	282	91	9	int:ATG3
Interaction	EFTUD2 interactions	CMBL CAD DNAAF10 EIF4A3 SMCHD1 RC3H1 COPB2 DKC1 TFIP11 AHCYL2 PFKL PFKM PFKP PRPF8 QARS1 DDX21 EXOSC2 TOP2B TUFM	2.08e-05	1449	91	19	int:EFTUD2
Interaction	BCL2L14 interactions	CAD FASTKD5 PFKL PFKM PFKP TUFM	2.39e-05	127	91	6	int:BCL2L14
Interaction	LRRC31 interactions	CAD SMCHD1 FRYL PRPF8 ITGB4 TOP2B TUFM	4.00e-05	205	91	7	int:LRRC31
Cytoband	21q22.3	DIP2A PFKL PDXK PCNT	1.39e-04	128	93	4	21q22.3
GeneFamily	WD repeat domain containing	WIPI1 NBEAL1 DNAAF10 COPB2 ELP2 DCAF4L1	2.73e-04	262	62	6	362
GeneFamily	Chloride voltage-gated channels	CLCN2 CLCN6	5.12e-04	10	62	2	302
GeneFamily	Low density lipoprotein receptors	LRP1 LRP1B	8.81e-04	13	62	2	634
GeneFamily	Cadherin related	DCHS2 CDH23	1.52e-03	17	62	2	24
GeneFamily	Fibrinogen C domain containing	ANGPTL6 TNN	3.30e-03	25	62	2	554
Coexpression	GSE40655_FOXO1_KO_VS_WT_NTREG_UP	PHF20L1 MYCBP2 MFSD6 PLEKHM3 PRPF8 TOP2B PCNT	6.87e-06	200	92	7	M9439
ToppCell	COVID-19-kidney-TAL\|kidney / Disease (COVID-19 only), tissue and cell type	TFCP2L1 NTRK2 PKHD1 ADGRV1 PFKP LRP1B PCDH9	1.85e-07	196	93	7	04f5eb206ed3016a737609a3ebac0c1fcabb94ef
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4\|TCGA-Pancreas / Sample_Type by Project: Shred V9	MYCBP2 ARHGAP31 NTRK2 GPR141 MPDZ PCDH9	2.45e-06	184	93	6	67164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	UPF2 PKHD1 LRP1 ADGRV1 DDX21 LRP1B	2.60e-06	186	93	6	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	COVID-19-kidney-Mito-rich_Distal\|kidney / Disease (COVID-19 only), tissue and cell type	TFCP2L1 NTRK2 PKHD1 ADGRV1 LRP1B PCDH9	2.69e-06	187	93	6	2ce8038d9d1302e850c1bb536e755598f77ba4b9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TFCP2L1 NTRK2 ADGRV1 LRP1B PCDH9 SH3BP4	2.94e-06	190	93	6	bf4511395fa97efd1c1cd17cc9bebb0271ee7f0e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TFCP2L1 NTRK2 ADGRV1 LRP1B PCDH9 SH3BP4	2.94e-06	190	93	6	b6b8964b4910083499681b5fdf554e127b6a4c4e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NTRK2 PKHD1 ADGRV1 LRP1B PCDH9 SH3BP4	3.03e-06	191	93	6	2fa1b9e76a0ed2d2f0de74349e266cf4a5f51aad
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Intermediate\|3m / Sample Type, Dataset, Time_group, and Cell type.	MYCBP2 NBEAL1 KAT8 PFKM DDX21 FEM1A	3.96e-06	200	93	6	cbd0b9188a94778ffa539912aeb2a4378f0ab88f
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKHD1 ADGRV1 RNF17 LRP1B DNAH9	2.80e-05	169	93	5	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SH3TC2 TFCP2L1 PFKP LRP1B PCDH9	3.99e-05	182	93	5	a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NTRK2 ADGRV1 LRP1B PCDH9 SH3BP4	3.99e-05	182	93	5	041bc819e6cf2618bf86bce8dfe2df673f392ba3
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TFCP2L1 NTRK2 ADGRV1 LRP1B PCDH9	4.10e-05	183	93	5	31ab55d5f3639f5964541d5eae23044dbda3356e
ToppCell	LPS-IL1RA\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC9C1 EVC2 ARHGAP31 NTRK2 PFKP	4.21e-05	184	93	5	c066c2ec4f0f1d6eb183fca5c7bb0cd45c9950dc
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCBP2 SMCHD1 PLEKHM3 DDX21 TOP2B	4.21e-05	184	93	5	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TFCP2L1 NTRK2 ADGRV1 LRP1B PCDH9	4.32e-05	185	93	5	898a093757f86be3e18d2ef1f16a71f50ef81dc3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TFCP2L1 PKHD1 PFKP LRP1B PCDH9	4.54e-05	187	93	5	87b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TFCP2L1 PKHD1 PFKP LRP1B PCDH9	4.54e-05	187	93	5	42a1267bfc27b4460b8409ada580a87c4385841c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TFCP2L1 PKHD1 PFKP LRP1B PCDH9	4.54e-05	187	93	5	64afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TFCP2L1 NTRK2 ADGRV1 LRP1B PCDH9	4.66e-05	188	93	5	2ee64bc73a2251fd9f374be759b442cf4ed0d19e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TFCP2L1 NTRK2 ADGRV1 LRP1B PCDH9	4.66e-05	188	93	5	3cee9916399e2e7580cecbcbb27424a71e7e7ac0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TFCP2L1 NTRK2 ADGRV1 LRP1B PCDH9	4.78e-05	189	93	5	e059be2965cca70ff5576df055d0af1775b76e00
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Neuron\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	EOMES MYCBP2 LRP1 PLEKHM3 PCDH9	4.78e-05	189	93	5	3717d1148e26ac78a26aea0ca1dbfbb9d3668877
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TFCP2L1 NTRK2 PKHD1 PFKP PCDH9	4.90e-05	190	93	5	3fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TFCP2L1 NTRK2 ADGRV1 LRP1B PCDH9	5.02e-05	191	93	5	963f4f2e852bbb4faf070aafb0d368297abacd3b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TFCP2L1 NTRK2 PKHD1 PFKP PCDH9	5.02e-05	191	93	5	5a67ff17fb4b9eff641176dff07830c9cd73754e
ToppCell	COVID-19-kidney-TAL\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TFCP2L1 NTRK2 PKHD1 PFKP LRP1B	5.02e-05	191	93	5	fe55475ce0666ab5122447a813dc2369e24947b8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TFCP2L1 NTRK2 PKHD1 PFKP PCDH9	5.02e-05	191	93	5	55ab2854a02cdcfc395e49870ccb7290b5e5471d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TFCP2L1 NTRK2 ADGRV1 LRP1B PCDH9	5.15e-05	192	93	5	562df5e87038c500dd3a003fe5374cb31946b145
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NTRK2 PKHD1 ADGRV1 PCDH9 PDXK	5.15e-05	192	93	5	ee27d27e3d269764dbe8711d0b37ff9331a298a9
ToppCell	mild-pDC\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	EIF4A3 CDH23 IDH3A TNFRSF21 SH3BP4	5.82e-05	197	93	5	15230a54fa5903dd728de1a0ad633bd2d2c7a04d
ToppCell	Skin-Mesangial\|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.	DCHS2 NLRP9 KCNC3 NTRK2 MPDZ	6.10e-05	199	93	5	bcb78838a91cc7828680fb413fbacdb091c5fac0
Drug	Uridine diphosphate 2-deoxyglucose	PFKL PFKM PFKP	2.46e-07	4	91	3	CID000165519
Drug	AC1MIX9B	PFKL PFKM PFKP	1.22e-06	6	91	3	CID003081623
Drug	glipentide	PFKL PFKM PFKP	2.14e-06	7	91	3	CID000065779
Drug	dactylarin	PFKL PFKM PFKP	2.14e-06	7	91	3	CID000161389
Drug	magnesium	CAD NUDT5 DNAAF10 EIF4A3 COPB2 MLH1 CTDSP1 DBH GRIN2A ADGRV1 IDH3A PFKL PFKM PFKP DNAH9 TOP2B TUFM PDXK	4.27e-06	1325	91	18	CID000000888
Drug	MOF-5	EIF1B KAT8 EIF1	5.10e-06	9	91	3	CID000139613
Drug	glyoxylate	DBH IDH3A PFKL PFKM PFKP TUFM ALG2	6.86e-06	176	91	7	CID000000760
Drug	aspartate	CAD CLCN2 CLCN6 NTRK2 GRIN2A IDH3A PFKL PFKM PFKP QARS1 SLC1A7	6.97e-06	518	91	11	CID000000424
Drug	Bromocryptine mesylate [22260-51-1]; Down 200; 5.4uM; HL60; HG-U133A	DIP2A CAD MYCBP2 DKC1 IDH3A DDX21 EXOSC2	8.24e-06	181	91	7	2007_DN
Drug	fructose 2-phosphorothioate 6-phosphate	PFKL PFKM PFKP	9.96e-06	11	91	3	CID000195184
Drug	C14:1n-5	PFKL PFKM PFKP	9.96e-06	11	91	3	CID000068344
Drug	(-)-Isoproterenol hydrochloride [5984-95-2]; Down 200; 16.2uM; HL60; HT_HG-U133A	DIP2A CAD DKC1 IDH3A DDX21 ITGB4 EXOSC2	1.17e-05	191	91	7	6149_DN
Drug	ara-Hx	UPF2 AHCYL2 PFKL PFKM PFKP QARS1 MAP4K2	1.25e-05	193	91	7	CID000000804
Drug	1i32	UPF2 EIF4A3 EIF1B MLH1 ADGRV1 EIF1	1.32e-05	129	91	6	CID000446186
Drug	2,3,5-tri-O-benzyl-D-arabinofuranose	PFKL PFKM	1.58e-05	2	91	2	CID000255457
Drug	TOP-53	MLH1 TOP2B	1.58e-05	2	91	2	CID000177859
Drug	AC1L1CRO	EIF1B DKC1 EIF1 PDXK	1.95e-05	40	91	4	CID000002029
Drug	Gabrene	CYP2C8 DBH PDXK GABRA3	1.95e-05	40	91	4	CID005361323
Drug	hydroxyl radicals	CMBL CAD CYP2C8 NUDT5 ACADS MYCBP2 EIF1B RBP3 LRP1 CTDSP1 DBH AHCYL2 IDH3A PFKL PFKM LRP1B TUFM	2.02e-05	1341	91	17	CID000000961
Drug	M 16209	PFKL PFKM PFKP	2.71e-05	15	91	3	CID000164260
Drug	dibenzyl succinate	PFKL PFKM PFKP	3.33e-05	16	91	3	CID000007653
Drug	flurothyl	DBH GRIN2A EXOSC2 PDXK	3.73e-05	47	91	4	CID000009528
Drug	Ravidomycin	MLH1 TOP2B	4.73e-05	3	91	2	CID000126647
Drug	AC1L977H	PFKL PFKM	4.73e-05	3	91	2	CID000439366
Drug	MoF4	UPF2 KAT8	4.73e-05	3	91	2	CID000141030
Drug	AC1L1AO2	PFKL PFKM PFKP	4.83e-05	18	91	3	CID000001073
Drug	BRL 26830A	PFKL PFKM PFKP	5.71e-05	19	91	3	CID006438331
Drug	archaeosine	EIF1B DKC1 EIF1	6.70e-05	20	91	3	CID000132841
Drug	netropsin	PFKL PFKM PFKP TOP2B	7.48e-05	56	91	4	CID000004461
Drug	arabinosyluracil	CAD NUDT5 UPF2 MLH1 DKC1 PFKL PRPF8 QARS1	8.73e-05	354	91	8	CID000001177
Drug	d-sedoheptulose 1,7-diphosphate	PFKL PFKM PFKP	9.00e-05	22	91	3	CID000001193
Drug	D-G-G	ANGPTL6 GRIN2A PCNT	1.03e-04	23	91	3	CID000444866
Drug	Adenosine 5'-monophosphate monohydrate [18422-05-4]; Down 200; 11uM; HL60; HG-U133A	CAD DKC1 TFIP11 DDX21 TNFRSF21 EXOSC2	1.09e-04	188	91	6	1622_DN
Drug	UDP-FGlc	UPF2 EIF4A3 EIF1B EIF1	1.12e-04	62	91	4	CID000125643
Drug	gamma-aminobutyric acid	CLCN2 CLCN6 NTRK2 DBH GRIN2A IDH3A SLC1A7 PDXK GABRA3	1.18e-04	474	91	9	CID000000119
Disease	glycogen storage disease (implicated_via_orthology)	PFKL PFKM PFKP	1.10e-07	4	90	3	DOID:2747 (implicated_via_orthology)
Disease	disease of metabolism (implicated_via_orthology)	PFKL PFKM PFKP	3.51e-05	21	90	3	DOID:0014667 (implicated_via_orthology)
Disease	cortical surface area measurement	DCHS2 CEP120 CLCN2 MYCBP2 NBEAL1 ARHGAP31 PKHD1 MLH1 FRYL PLEKHM3 ADGRV1 QARS1 RPS6KL1 TUFM	5.51e-05	1345	90	14	EFO_0010736
Disease	Colorectal Carcinoma	CAD EVC2 RBP3 PKHD1 LRP1 MLH1 DIP2C GRIN2A SLC1A7	2.95e-04	702	90	9	C0009402
Disease	pulse pressure measurement, migraine without aura, susceptibility to, 4	LRP1 SLC35B1	3.27e-04	9	90	2	EFO_0005763, MONDO_0011847
Disease	Ciliopathies	EVC2 PKHD1 CDH23 ADGRV1	3.65e-04	110	90	4	C4277690
Disease	Bipolar Disorder	ACADS NTRK2 DBH GRIN2A PFKL GABRA3 PCNT	6.50e-04	477	90	7	C0005586
Disease	lysophosphatidylcholine 15:0 measurement	PKHD1 LRP1B	8.17e-04	14	90	2	EFO_0020941
Disease	susceptibility to vaginal yeast infection measurement	EIF4A3 NTRK2 PKHD1	1.05e-03	65	90	3	EFO_0008412
Disease	Astrocytosis	TNFRSF21 ITGB4	1.21e-03	17	90	2	C3887640
Disease	Gliosis	TNFRSF21 ITGB4	1.21e-03	17	90	2	C0017639
Disease	epilepsy (implicated_via_orthology)	LRP1 GRIN2A LRP1B SLC1A7	1.59e-03	163	90	4	DOID:1826 (implicated_via_orthology)
Disease	Mood Disorders	NTRK2 DBH GRIN2A PFKL	1.77e-03	168	90	4	C0525045
Disease	Headache, HbA1c measurement	NBEAL1 PFKM	1.86e-03	21	90	2	EFO_0004541, HP_0002315

Protein segments in the cluster

Peptide	Gene	Start	Entry
YQPRLHIVEVTEDGV	EOMES	396	O95936
YEGTSEIQRLVIAGH	ACADS	391	P16219
YVGGEIVTIAHLDRT	COPB2	546	P35606
HVTRGAGEVITAYEV	ADGRV1	3916	Q8WXG9
EGGVRTIILTIYPHE	ADGRV1	4586	Q8WXG9
VVHEIQRYSDLVPTG	CYP2C8	351	P10632
GTVIEHPEYGEVIQL	EIF1B	71	O60739
EYILIVRAVDGGVGH	CDH23	741	Q9H251
HHYGLDRGVENEIVV	EFCC1	36	Q9HA90
DVIPGRLEITTQHIY	NBEAL1	1901	Q6ZS30
LVAVRTVVHGLVDYI	RC3H1	381	Q5TC82
IVVPLVVSRYGIHEE	GPR141	146	Q7Z602
LVVGAEEGIYTLNLH	MAP4K2	501	Q12851
HENVVVVTIQYRLGI	CES1P1	161	Q9UKY3
TVIQGRQVRHLYGIT	LRP1B	406	Q9NZR2
VFGIEVVEVVRIGHL	MAGEA12	161	P43365
VVEVVRIGHLYILVT	MAGEA12	166	P43365
YILTEVDRQGAHIVG	KAT8	286	Q9H7Z6
RQTIIQGILIEHLYG	LRP1	401	Q07954
QGILIEHLYGLTVFE	LRP1	406	Q07954
VIIRVSHGINTGYAI	AQP7B	216	A0A075B734
IVRHVVDYIEEHGGL	FAM13B	41	Q9NYF5
VGEDIRKLDYGQHVV	EIF4A3	146	P38919
EGIVVAVGQDCYTRI	DCAF4L1	326	Q3SXM0
RGTGVIQLYEIQHGD	DNAAF10	41	Q96MX6
GTVIEHPEYGEVIQL	EIF1	71	P41567
GVAVIPVLQRTLHYE	NUDT5	61	Q9UKK9
VGLHRLVVNISDLGY	PCDH9	746	Q9HC56
QLESIVENIRIYGIH	PFKL	476	P17858
VENIRIYGIHALLVV	PFKL	481	P17858
RLGYDTRVTVLGHVQ	PFKM	286	P08237
LGYDTRVTILGHVQR	PFKP	296	Q01813
IPVEIDGVVHQVYVL	CTDSP1	116	Q9GZU7
GNVHIIADLYAEVIG	FRYL	171	O94915
LVTNVVLEEHYLIVG	DIP2B	1521	Q9P265
VLEEHYLIVGVVVVV	DIP2B	1526	Q9P265
ITHRLYGDISREVQG	EVC2	146	Q86UK5
NQYDLLGHVVGTEII	GABRA3	241	P34903
EHEVQIYVGEIVLAL	RPS6KA5	151	O75582
LLARQIGVEHVVVYV	TUFM	166	P49411
VYGIQEVPELVGHEV	PLEKHM3	36	Q6ZWE6
SVGIGIDYTHIEVLI	MFSD6	341	Q6ZSS7
YIGEVGDIVVGRITE	EXOSC2	76	Q13868
GIYQVQLRALEHVDG	ITGB4	406	P16144
YIHHLEVIQQRLGGV	PCNT	3306	O95613
VHYTEGALVVRVLDV	DCHS2	2426	Q6V1P9
VGEIVGIITRHNLTY	CLCN6	841	P51797
LVHLIYVIGENRQVS	FASTKD5	281	Q7L8L6
GEYSGIEHVIVDGVV	IDH3A	151	P50213
RILIYGVQEENGSHV	SLC1A7	181	O00341
DIVAVLNEEGGYHQI	CEP120	166	Q8N960
IEDGTVHLVYGILEE	DBH	161	P09172
DGHLEVVRYLVGEHQ	FEM1A	126	Q9BSK4
YITGHVLVVDGGLQL	CBR4	221	Q8N4T8
RVLQAIDSIHQVGVY	DIP2C	861	Q9Y2E4
LVTNVVLEEHYLIVG	DIP2C	1501	Q9Y2E4
VLEEHYLIVGVVVVV	DIP2C	1506	Q9Y2E4
SGVYELRVGRHVVSV	ANGPTL6	271	Q8NI99
EVDAYGTVQPHTIIR	DNAH9	2551	Q9NYC9
VLHPSQRYVVAVGLE	ELP2	731	Q6IA86
RVLQAIDSIHQVGVY	DIP2A	876	Q14689
LVTNVVLEEHYLVVG	DIP2A	1516	Q14689
VLEEHYLVVGVVVIV	DIP2A	1521	Q14689
VIGDVIRVYSGHQGR	DDX21	426	Q9NR30
KEYVGIVRLHNAIEG	DKC1	151	O60832
IYDTIHGIRGEINVV	C2CD5	111	Q86YS7
YRAVIIHGFVEELVV	C2CD5	156	Q86YS7
LAGLVLYQEDVGIHV	UPF2	831	Q9HAU5
LYQEDVGIHVVDGVL	UPF2	836	Q9HAU5
ADVYGVTEVLHGLQL	PHF20L1	776	A8MW92
VGLRHTGYVIELQHV	QARS1	636	P47897
GIVEESVTGVHRLYQ	AHCYL2	331	Q96HN2
HVEGDGVVEGIIRYH	SMCHD1	416	A6NHR9
TKGGRHVDYVVDQVV	TOP2B	341	Q02880
IGTYRHVDRATGQVL	TNFRSF21	51	O75509
ENLIYVILIHGAVED	SLC9C1	1046	Q4G0N8
IGDSYRDVIQELHLG	SH3BP4	906	Q9P0V3
YGDIVERHLIDGDVV	POLR3A	446	O14802
HELDVVAYVLRQGIV	SH3TC2	611	Q8TF17
GLYTLHVTIDGIEID	MYCBP2	2421	O75592
YLVSGEGQVQVILRV	PKHD1	2701	P08F94
RVYRQGPTGIHVVVS	TFCP2L1	431	Q9NZI6
ILEVVGRYSVHNAGI	MLH1	176	P40692
RVLSIQSHVIRGYVG	PDXK	6	O00764
VVGIEEHTVGYGELL	SLC35B1	161	P78383
RVHLIVAGGYDERVL	ALG2	261	Q9H553
LEYGGLGREVQVEHI	CMBL	16	Q96DG6
DHAYVTSIGRLIGIV	CLCN2	816	P51788
VQSIVGQGYHRKIVL	CNOT10	421	Q9H9A5
EEVFIYIGNIEHLVI	NLRP9	566	Q7RTR0
TGREHLSVYAVVVIA	NTRK2	426	Q16620
EVVGGAVRVQYLDHG	RNF17	1251	Q9BXT8
EQIRDVPVLYHITGA	PRPF8	111	Q6P2Q9
LRHEVLEGNVGYLRV	RBP3	121	P10745
LGAIIIHEVYEEGAA	MPDZ	1651	O75970
VLTGLRPGVEYTVHV	TNN	586	Q9UQP3
YQNGVDVLLRGIHVD	RPS6KL1	76	Q9Y6S9
ETHGIVDGIYRLSGV	ARHGAP31	46	Q2M1Z3
VVLRGEVAYIDGQVL	CAD	1786	P27708
VHGSNEIPDVYIVER	WIPI1	51	Q5MNZ9
RIVIYIDRGVVFVQG	TFIP11	806	Q9UBB9
VINVGGVRHETYRST	KCNC3	91	Q14003
IGRIHTYLELIGAIN	MYSM1	446	Q5VVJ2
TEEGYQVHPRLVVIV	GRIN2A	351	Q12879