Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmetalloendopeptidase activity

OMA1 ADAM15 MMP23B ADAMTS13 ADAMTS5 MMP20 ADAM10 ADAMTS12 MMP25 MMP24 ADAMTS7 ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

5.44e-2512012321GO:0004222
GeneOntologyMolecularFunctionmetallopeptidase activity

OMA1 ADAM15 MMP23B ADAMTS13 ADAMTS5 MMP20 ADAM10 ADAMTS12 MMP25 MMP24 ADAMTS7 ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

3.62e-2020012321GO:0008237
GeneOntologyMolecularFunctionendopeptidase activity

OMA1 ADAM15 MMP23B ADAMTS13 ADAMTS5 MMP20 ADAM10 ADAMTS12 MMP25 MMP24 ADAMTS7 ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

2.01e-1343012321GO:0004175
GeneOntologyMolecularFunctionpeptidase activity

OMA1 USP28 ADAM15 MMP23B USP24 ADAMTS13 ADAMTS5 MMP20 ADAM10 ADAMTS12 MMP25 MMP24 USP51 ADAMTS7 ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

1.53e-1265412324GO:0008233
GeneOntologyMolecularFunctionzinc ion binding

MYCBP2 MMP23B FBXO11 ADAMTS13 ADAMTS5 MMP20 ADA2 RXRB SLC30A7 MMP25 IFIH1 MMP24 USP51 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17 SOD1

4.74e-0989112323GO:0008270
GeneOntologyMolecularFunctiontransition metal ion binding

MYCBP2 MMP23B FBXO11 ADAMTS13 ADAMTS5 MMP20 ADA2 RXRB SLC30A7 MMP25 IFIH1 MMP24 USP51 CYP7B1 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17 SOD1

2.23e-07118912324GO:0046914
GeneOntologyMolecularFunctiontriacylglycerol lipase activity

PNLIP PNLIPRP1 PNLIPRP2 LIPC

1.85e-05261234GO:0004806
GeneOntologyMolecularFunctionserine-type endopeptidase activity

ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14

2.35e-051901238GO:0004252
GeneOntologyMolecularFunctionserine-type peptidase activity

ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14

4.33e-052071238GO:0008236
GeneOntologyMolecularFunctionserine hydrolase activity

ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14

5.12e-052121238GO:0017171
GeneOntologyMolecularFunctionmetalloexopeptidase activity

ADAM10 ADAM17 MMP14 MMP15 MMP17

7.18e-05701235GO:0008235
GeneOntologyMolecularFunctionmonoacylglycerol lipase activity

PNLIPRP2 MGLL LIPC

1.20e-04161233GO:0047372
GeneOntologyMolecularFunctionmannose-ethanolamine phosphotransferase activity

PIGN PIGO

2.24e-0441232GO:0051377
GeneOntologyMolecularFunctionmetalloendopeptidase activity involved in amyloid precursor protein catabolic process

ADAM10 ADAM17

2.24e-0441232GO:1902945
GeneOntologyMolecularFunctioncarboxylic ester hydrolase activity

NDST1 PNLIP PNLIPRP1 PNLIPRP2 MGLL LIPC

4.28e-041571236GO:0052689
GeneOntologyMolecularFunctionmetalloaminopeptidase activity

MMP14 MMP15 MMP17

5.35e-04261233GO:0070006
GeneOntologyMolecularFunctionexopeptidase activity

ADAM10 ADAM17 MMP14 MMP15 MMP17

5.97e-041101235GO:0008238
GeneOntologyMolecularFunctionintegrin binding

ADAM15 ADAMTS13 ADAMTS5 ADAM10 ADAM17 MMP14

7.58e-041751236GO:0005178
GeneOntologyMolecularFunctiontumor necrosis factor binding

ADAM17 MMP8

7.75e-0471232GO:0043120
GeneOntologyMolecularFunctionmetallodipeptidase activity

ADAM10 ADAM17

1.64e-03101232GO:0070573
GeneOntologyMolecularFunctionlipase activity

PNLIP PNLIPRP1 PNLIPRP2 MGLL LIPC

1.65e-031381235GO:0016298
GeneOntologyMolecularFunctionligase activity, forming carbon-oxygen bonds

YARS2 FARSA CARS2

2.20e-03421233GO:0016875
GeneOntologyMolecularFunctionaminoacyl-tRNA ligase activity

YARS2 FARSA CARS2

2.20e-03421233GO:0004812
GeneOntologyMolecularFunctionaminopeptidase activity

MMP14 MMP15 MMP17

2.35e-03431233GO:0004177
GeneOntologyBiologicalProcesscollagen catabolic process

ADAM15 MMP23B MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

6.64e-205312314GO:0030574
GeneOntologyBiologicalProcesscollagen metabolic process

ADAM15 MMP23B MMP20 MMP25 MMP24 RAPGEF3 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

1.21e-1414812315GO:0032963
GeneOntologyBiologicalProcessextracellular matrix disassembly

ADAM15 ADAMTS5 MMP20 ADAM10 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15

2.22e-147512312GO:0022617
GeneOntologyBiologicalProcessextracellular matrix organization

ADAM15 MMP23B ADAMTS13 ADAMTS5 MMP20 ADAM10 ADAMTS12 MMP25 MMP24 ADAMTS7 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

1.03e-1237712319GO:0030198
GeneOntologyBiologicalProcessextracellular structure organization

ADAM15 MMP23B ADAMTS13 ADAMTS5 MMP20 ADAM10 ADAMTS12 MMP25 MMP24 ADAMTS7 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

1.08e-1237812319GO:0043062
GeneOntologyBiologicalProcessexternal encapsulating structure organization

ADAM15 MMP23B ADAMTS13 ADAMTS5 MMP20 ADAM10 ADAMTS12 MMP25 MMP24 ADAMTS7 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

1.14e-1237912319GO:0045229
GeneOntologyBiologicalProcessprotein catabolic process

OMA1 TRIB2 MYCBP2 USP28 LRRK2 HIPK2 FBXO11 ADAMTS13 MMP20 ADAM10 ADAMTS12 ADAMTS7 MMP3 ASCC3 MMP8 MMP9 MMP13 MMP14 ZNF418 TMUB2

9.51e-06111512320GO:0030163
GeneOntologyBiologicalProcesscellular component disassembly

ADAM15 ADAMTS5 MMP20 ADAM10 ATAD2B MMP1 MMP3 ASCC3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15

1.91e-0561712314GO:0022411
GeneOntologyBiologicalProcesscellular response to UV-A

MMP1 MMP3 MMP9

3.30e-05111233GO:0071492
GeneOntologyBiologicalProcessresponse to UV-A

MMP1 MMP3 MMP9

8.94e-05151233GO:0070141
GeneOntologyBiologicalProcessregulation of neuroinflammatory response

LRRK2 MMP3 MMP8 MMP9

1.62e-04461234GO:0150077
GeneOntologyCellularComponentextracellular matrix

LAMB4 MMP23B ADAMTS13 ADAMTS5 MMP20 ADAM10 ZP3 ADAMTS12 MMP25 MMP24 ADAMTS7 LINGO4 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

3.30e-1065612521GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

LAMB4 MMP23B ADAMTS13 ADAMTS5 MMP20 ADAM10 ZP3 ADAMTS12 MMP25 MMP24 ADAMTS7 LINGO4 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

3.49e-1065812521GO:0030312
GeneOntologyCellularComponentt-UTP complex

HEATR1 UTP4

1.06e-0431252GO:0034455
GeneOntologyCellularComponentRAVE complex

DMXL2 DMXL1

1.06e-0431252GO:0043291
GeneOntologyCellularComponent90S preribosome

HEATR1 UTP4 PWP2

6.81e-04291253GO:0030686
DomainPept_M10_metallopeptidase

ADAM15 MMP23B ADAMTS13 MMP20 ADAM10 ADAMTS12 MMP25 MMP24 ADAMTS7 ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

6.93e-314312419IPR001818
DomainCYSTEINE_SWITCH

ADAM15 MMP20 ADAM10 ADAMTS12 MMP25 MMP24 ADAMTS7 ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

4.02e-274112417PS00546
Domain-

ADAM15 MMP23B ADAMTS13 ADAMTS5 MMP20 ADAM10 ADAMTS12 MMP25 MMP24 ADAMTS7 ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

1.88e-2681124203.40.390.10
DomainMetalloPept_cat_dom

ADAM15 MMP23B ADAMTS13 ADAMTS5 MMP20 ADAM10 ADAMTS12 MMP25 MMP24 ADAMTS7 ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

1.88e-268112420IPR024079
DomainZINC_PROTEASE

OMA1 ADAM15 MMP23B ADAMTS13 ADAMTS5 MMP20 ADAM10 ADAMTS12 MMP25 MMP24 ADAMTS7 ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

2.61e-269812421PS00142
DomainPeptidase_M10

MMP23B ADAMTS13 MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

2.81e-252412414PF00413
DomainM10A_MMP

MMP23B MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

2.76e-232312413IPR033739
DomainPept_M10A

MMP23B MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

2.76e-232312413IPR021190
DomainPG_binding_1

MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

5.12e-222012412PF01471
DomainPeptidoglycan-bd-like

MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

5.12e-222012412IPR002477
DomainPeptidase_Metallo

MMP23B MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

1.58e-212912413IPR006026
DomainZnMc

MMP23B MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

1.58e-212912413SM00235
DomainHemopexin-like_dom

MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

5.40e-212312412IPR000585
DomainHemopexin-like_repeat

MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

5.40e-212312412IPR018487
DomainHEMOPEXIN

MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

5.40e-212312412PS00024
Domain-

MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

5.40e-2123124122.110.10.10
DomainHEMOPEXIN_2

MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

5.40e-212312412PS51642
DomainHX

MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

5.40e-212312412SM00120
DomainHemopexin

MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

5.40e-212312412PF00045
DomainPept_M10A_stromelysin-type

MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP10 MMP13 MMP14 MMP15 MMP17

2.15e-201812411IPR016293
DomainPept_M10A_Zn_BS

MMP20 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15

9.03e-17151249IPR021158
DomainHemopexin_CS

MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15

4.34e-16171249IPR018486
DomainDISINTEGRIN_1

ADAM15 ADAMTS13 ADAMTS5 ADAM10 ADAMTS12 ADAMTS7 ADAM17

7.45e-09401247PS00427
DomainReprolysin

ADAM15 ADAMTS13 ADAMTS5 ADAM10 ADAMTS12 ADAMTS7 ADAM17

7.45e-09401247PF01421
DomainADAM_MEPRO

ADAM15 ADAMTS13 ADAMTS5 ADAM10 ADAMTS12 ADAMTS7 ADAM17

7.45e-09401247PS50215
DomainDISINTEGRIN_2

ADAM15 ADAMTS13 ADAMTS5 ADAM10 ADAMTS12 ADAMTS7 ADAM17

7.45e-09401247PS50214
DomainPeptidase_M12B

ADAM15 ADAMTS13 ADAMTS5 ADAM10 ADAMTS12 ADAMTS7 ADAM17

7.45e-09401247IPR001590
DomainDisintegrin_dom

ADAM15 ADAMTS13 ADAMTS5 ADAM10 ADAMTS12 ADAMTS7 ADAM17

8.94e-09411247IPR001762
DomainPep_M12B_propep

ADAM15 ADAMTS5 ADAM10 ADAMTS12 ADAMTS7 ADAM17

2.07e-07391246PF01562
DomainPeptidase_M12B_N

ADAM15 ADAMTS5 ADAM10 ADAMTS12 ADAMTS7 ADAM17

2.07e-07391246IPR002870
DomainLipase/vitellogenin

PNLIP PNLIPRP1 PNLIPRP2 LIPC

3.77e-07101244IPR013818
DomainTAG_lipase

PNLIP PNLIPRP1 PNLIPRP2 LIPC

3.77e-07101244IPR000734
DomainLipase

PNLIP PNLIPRP1 PNLIPRP2 LIPC

3.77e-07101244PF00151
DomainLipase_N

PNLIP PNLIPRP1 PNLIPRP2 LIPC

3.77e-07101244IPR033906
DomainLipase_LIPH

PNLIP PNLIPRP1 PNLIPRP2 LIPC

3.77e-07101244IPR016272
DomainLIPASE_SER

PNLIP PNLIPRP1 PNLIPRP2 MGLL LIPC

7.00e-07261245PS00120
DomainLipase_panc

PNLIP PNLIPRP1 PNLIPRP2

1.14e-0641243IPR002331
DomainDUF3377

MMP24 MMP14 MMP15

1.14e-0641243PF11857
DomainPept_M10A_metallopeptidase_C

MMP24 MMP14 MMP15

1.14e-0641243IPR021805
DomainLH2

PNLIP PNLIPRP1 PNLIPRP2 LIPC

5.27e-06181244SM00308
Domain-

PNLIP PNLIPRP1 PNLIPRP2 LIPC

1.01e-052112442.60.60.20
DomainPLAT

PNLIP PNLIPRP1 PNLIPRP2 LIPC

1.01e-05211244PF01477
DomainPLAT/LH2_dom

PNLIP PNLIPRP1 PNLIPRP2 LIPC

1.01e-05211244IPR001024
DomainPLAT

PNLIP PNLIPRP1 PNLIPRP2 LIPC

1.01e-05211244PS50095
DomainPeptidase_M12B_ADAM-TS

ADAMTS13 ADAMTS5 ADAMTS12 ADAMTS7

1.77e-05241244IPR013273
DomainRav1p_C

DMXL2 DMXL1

4.37e-0521242IPR022033
DomainRav1p_C

DMXL2 DMXL1

4.37e-0521242PF12234
Domain-

ADAM15 ADAM10 ADAM17

3.00e-042012434.10.70.10
DomainDisintegrin

ADAM15 ADAM10 ADAM17

3.48e-04211243PF00200
DomainDISIN

ADAM15 ADAM10 ADAM17

3.48e-04211243SM00050
DomainWD40/YVTN_repeat-like_dom

DMXL2 MED16 LRRK2 BIRC6 WDFY4 DMXL1 UTP4 PWP2 PHIP

4.02e-043351249IPR015943
DomainQuinoprotein_ADH-like_supfam

DMXL2 UTP4 PWP2 PHIP

4.21e-04531244IPR011047
DomainWD40

DMXL2 MED16 LRRK2 WDFY4 DMXL1 UTP4 PWP2 PHIP

4.25e-042681248SM00320
DomainADAM_spacer1

ADAMTS5 ADAMTS12 ADAMTS7

4.59e-04231243IPR010294
DomainADAM_spacer1

ADAMTS5 ADAMTS12 ADAMTS7

4.59e-04231243PF05986
DomainWD40_repeat

DMXL2 MED16 LRRK2 WDFY4 DMXL1 UTP4 PWP2 PHIP

4.69e-042721248IPR001680
DomainADAM_Cys-rich

ADAM15 ADAMTS13 ADAMTS5

7.44e-04271243IPR006586
DomainACR

ADAM15 ADAMTS13 ADAMTS5

7.44e-04271243SM00608
DomainTSP_1

ADAMTS13 ADAMTS5 ADAMTS12 ADAMTS7

8.15e-04631244PF00090
DomainWD40_repeat_dom

DMXL2 MED16 LRRK2 WDFY4 DMXL1 UTP4 PWP2 PHIP

8.33e-042971248IPR017986
DomainTSP1

ADAMTS13 ADAMTS5 ADAMTS12 ADAMTS7

9.17e-04651244SM00209
DomainTSP1_rpt

ADAMTS13 ADAMTS5 ADAMTS12 ADAMTS7

9.17e-04651244IPR000884
DomainTSP1

ADAMTS13 ADAMTS5 ADAMTS12 ADAMTS7

9.17e-04651244PS50092
Domain-

PNLIP PNLIPRP1 PNLIPRP2 MGLL LIPC

1.19e-0311912453.40.50.1820
DomainAB_hydrolase

PNLIP PNLIPRP1 PNLIPRP2 MGLL LIPC

1.19e-031191245IPR029058
Domain-

DMXL2 MED16 LRRK2 BIRC6 WDFY4 DMXL1 UTP4 PHIP

1.73e-0333312482.130.10.10
DomainWD40

DMXL2 MED16 WDFY4 DMXL1 UTP4 PWP2 PHIP

1.73e-032591247PF00400
DomainCation_efflux

SLC30A1 SLC30A7

1.90e-03101242IPR002524
DomainLeu-rich_rpt_4

LRRK2 NLRC5

1.90e-03101242IPR025875
DomainCation_efflux

SLC30A1 SLC30A7

1.90e-03101242PF01545
DomainPhosphodiest/P_Trfase

PIGN PIGO

1.90e-03101242IPR002591
DomainPhosphodiest

PIGN PIGO

1.90e-03101242PF01663
DomainLRR_4

LRRK2 NLRC5

1.90e-03101242PF12799
DomainCation_efflux_TMD

SLC30A1 SLC30A7

2.31e-03111242IPR027469
Domain-

SLC30A1 SLC30A7

2.31e-031112421.20.1510.10
DomainWD_REPEATS_1

DMXL2 MED16 WDFY4 DMXL1 UTP4 PWP2 PHIP

2.57e-032781247PS00678
DomainWD_REPEATS_2

DMXL2 MED16 WDFY4 DMXL1 UTP4 PWP2 PHIP

2.63e-032791247PS50082
DomainWD_REPEATS_REGION

DMXL2 MED16 WDFY4 DMXL1 UTP4 PWP2 PHIP

2.63e-032791247PS50294
DomainRossmann-like_a/b/a_fold

YARS2 GMPS CARS2

2.90e-03431243IPR014729
Domain-

YARS2 GMPS CARS2

2.90e-034312433.40.50.620
PathwayWP_MATRIX_METALLOPROTEINASES

MMP23B MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

5.44e-212910413MM15981
PathwayWP_MATRIX_METALLOPROTEINASES

MMP23B MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

9.54e-213010413M39652
PathwayWP_CHRONIC_HYPERGLYCEMIA_IMPAIRMENT_OF_NEURON_FUNCTION

MMP23B MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

7.36e-184610413M46450
PathwayREACTOME_ACTIVATION_OF_MATRIX_METALLOPROTEINASES

MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

3.46e-163310411M26976
PathwayREACTOME_ACTIVATION_OF_MATRIX_METALLOPROTEINASES

MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

2.09e-153810411MM14611
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

ADAM15 ADAMTS5 MMP20 ADAM10 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

4.21e-1511410415MM14571
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

ADAM15 ADAMTS5 MMP20 ADAM10 MMP25 MMP24 ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

4.72e-1514010416M587
PathwayREACTOME_COLLAGEN_DEGRADATION

MMP20 ADAM10 ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15

1.10e-126410411M26953
PathwayREACTOME_COLLAGEN_DEGRADATION

MMP20 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15

1.54e-10531049MM14566
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

ADAM15 ADAMTS5 MMP20 ADAM10 MMP25 MMP24 ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

5.84e-1030010416M610
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

ADAM15 ADAMTS5 MMP20 ADAM10 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

6.44e-1025810415MM14572
PathwayREACTOME_DIGESTION_OF_DIETARY_LIPID

PNLIP PNLIPRP1 PNLIPRP2

7.68e-0661043MM14738
PathwayREACTOME_DIGESTION_OF_DIETARY_LIPID

PNLIP PNLIPRP1 PNLIPRP2

1.34e-0571043M27069
PathwayKEGG_GLYCEROLIPID_METABOLISM

PNLIP PNLIPRP1 PNLIPRP2 MGLL LIPC

2.92e-05491045M15902
PathwayWP_IL18_SIGNALING

ADAMTS5 RXRB MMP1 MMP3 FUT1 MMP8 MMP9 MMP13 MMP14

1.85e-042731049M39818
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS13 ADAMTS5 ADAMTS12 ADAMTS7

1.89e-04391044M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS13 ADAMTS5 ADAMTS12 ADAMTS7

1.89e-04391044MM15165
PathwayREACTOME_DIGESTION

PNLIP PNLIPRP1 PNLIPRP2

4.71e-04211043MM15526
PathwayREACTOME_ASSEMBLY_OF_COLLAGEN_FIBRILS_AND_OTHER_MULTIMERIC_STRUCTURES

MMP20 MMP3 MMP9 MMP13

4.96e-04501044MM14796
PathwayREACTOME_DIGESTION

PNLIP PNLIPRP1 PNLIPRP2

6.20e-04231043M27790
PathwayREACTOME_DIGESTION_AND_ABSORPTION

PNLIP PNLIPRP1 PNLIPRP2

7.97e-04251043MM15557
PathwayREACTOME_ASSEMBLY_OF_COLLAGEN_FIBRILS_AND_OTHER_MULTIMERIC_STRUCTURES

MMP20 MMP3 MMP9 MMP13

1.06e-03611044M27103
PathwayREACTOME_SIGNALING_BY_NOTCH1_T_7_9_NOTCH1_M1580_K2555_TRANSLOCATION_MUTANT

ADAM10 ADAM17

1.11e-0371042M27199
PathwayKEGG_MEDICUS_VARIANT_TMPRSS2_ERG_FUSION_TO_TRANSCRIPTIONAL_ACTIVATION

MMP3 MMP9

1.11e-0371042M47443
PathwayREACTOME_DIGESTION_AND_ABSORPTION

PNLIP PNLIPRP1 PNLIPRP2

1.12e-03281043M27837
Pubmed

Functional interactions between matrix metalloproteinases and glycosaminoglycans.

MMP23B MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

4.74e-27221261323421805
Pubmed

Matrix metalloproteinases.

MMP23B MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

4.74e-27221261310419448
Pubmed

Matrix metalloproteinases in tumor invasion.

MMP23B MMP20 MMP24 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

3.88e-24161261110949577
Pubmed

Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo.

MMP23B MMP20 MMP24 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

2.16e-21241261115734845
Pubmed

Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection.

MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

5.02e-19361261120587546
Pubmed

Association of matrix metalloproteinase gene polymorphisms with refractive error in Amish and Ashkenazi families.

MMP20 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14

2.97e-1616126820484597
Pubmed

Expression dynamics of metalloproteinases during mandibular bone formation: association with Myb transcription factor.

MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15

2.97e-1616126837701782
Pubmed

Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes.

MMP23B MMP20 MMP8 MMP13 MMP14 MMP15 MMP17

2.26e-1511126710949161
Pubmed

Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation.

MMP1 MMP3 MMP8 MMP9 MMP10 MMP13

1.40e-147126611113146
Pubmed

Expression analysis of the entire MMP and TIMP gene families during mouse tissue development.

ADAM15 MMP20 ADAM10 MMP3 MMP8 MMP10 MMP13

3.36e-1319126715063736
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

DMXL2 ADAM15 USP24 HIPK2 MMP20 DMXL1 ADAMTS12 MMP25 MMP24 CLK1 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 CARS2 MMP14 MMP15 MMP17

2.26e-127301262034857952
Pubmed

Metalloproteinases promote plaque rupture and myocardial infarction: A persuasive concept waiting for clinical translation.

MMP25 MMP8 MMP9 MMP10 MMP13 MMP14

5.88e-1214126625636537
Pubmed

Fine physical mapping of the human matrix metalloproteinase genes clustered on chromosome 11q22.3.

MMP20 MMP1 MMP3 MMP8 MMP10

1.20e-11712658921407
Pubmed

Expression of extracellular matrix metalloproteinase inducer and matrix metalloproteinases during mouse embryonic development.

MMP1 MMP3 MMP8 MMP9 MMP13

1.20e-117126517307908
Pubmed

Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP).

MMP20 MMP1 MMP3 MMP8 MMP14

1.20e-117126510922468
Pubmed

Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain.

MMP1 MMP3 MMP8 MMP9 MMP14

1.20e-11712658216228
Pubmed

Membrane-type matrix metalloproteinases: Their functions and regulations.

MMP25 MMP24 MMP14 MMP15 MMP17

1.20e-117126525794647
Pubmed

Matrix remodeling by MMPs during wound repair.

MMP1 MMP8 MMP9 MMP13 MMP14

1.20e-117126525770908
Pubmed

Characterization of opticin digestion by proteases involved in osteoarthritis development.

ADAMTS5 MMP1 MMP3 MMP8 MMP9

3.20e-118126523845380
Pubmed

Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites.

MMP1 MMP3 MMP8 MMP10 MMP13

7.18e-119126510986281
Pubmed

Genetic variations in matrix metalloproteinases may be associated with increased risk of ulcerative colitis.

MMP3 MMP8 MMP10 MMP14

1.64e-104126421925226
Pubmed

[The system of matrix metalloproteinases and their role in patients with pulmonary tuberculosis].

MMP1 MMP3 MMP8 MMP9

1.64e-104126427797337
Pubmed

Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo.

MMP1 MMP3 MMP8 MMP13 MMP14

4.47e-1012126512149192
Pubmed

Differential expression of tissue inhibitor of metalloproteinases type 1 (TIMP-1) during mouse gonad development.

MMP1 MMP3 MMP9 MMP13 MMP14

7.24e-1013126512815621
Pubmed

Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms.

MMP1 MMP3 MMP9 MMP10 MMP13

7.24e-1013126515944607
Pubmed

Immunohistochemical and transcriptional expression of matrix metalloproteinases in full-term human umbilical cord and human umbilical vein endothelial cells.

MMP3 MMP9 MMP10 MMP13

8.19e-105126420936527
Pubmed

MT1-MMP-dependent remodeling of cardiac extracellular matrix structure and function following myocardial infarction.

MMP8 MMP9 MMP13 MMP14

8.19e-105126422464947
Pubmed

Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF-α activation.

ADAM17 MMP3 MMP8 MMP9

8.19e-105126425049354
Pubmed

Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domain.

ADAMTS5 MMP1 MMP8 MMP14

8.19e-10512649688535
Pubmed

Matrix metalloproteinase circulating levels, genetic polymorphisms, and susceptibility to acute myocardial infarction among patients with coronary artery disease.

MMP1 MMP3 MMP9 MMP10

8.19e-105126418035073
Pubmed

mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue.

MMP24 MMP14 MMP15 MMP17

8.19e-105126412661033
Pubmed

Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice.

MMP1 MMP8 MMP9 MMP13 MMP14

1.12e-0914126516236725
Pubmed

A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).

LIPC MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

1.69e-091861261020673868
Pubmed

Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.

LIPC MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

1.69e-091861261020452482
Pubmed

Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3.

MMP1 MMP3 MMP13 MMP14

2.45e-096126410947989
Pubmed

Matrix metalloproteinase single-nucleotide polymorphisms and haplotypes predict breast cancer progression.

MMP1 MMP3 MMP9 MMP13

2.45e-096126418006768
Pubmed

Matrix metalloproteinase polymorphisms and bladder cancer risk.

MMP1 MMP3 MMP8 MMP9

2.45e-096126417178858
Pubmed

Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases.

MMP1 MMP3 MMP9 MMP14

2.45e-096126415863497
Pubmed

ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors.

MMP1 MMP3 MMP8 MMP14

2.45e-096126412054629
Pubmed

Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan.

MMP1 MMP3 MMP8 MMP14

2.45e-09612647998967
Pubmed

Matrix metalloproteinase polymorphisms are associated with bladder cancer invasiveness.

MMP1 MMP3 MMP8 MMP9

2.45e-096126417473191
Pubmed

Promoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progression.

MMP1 MMP3 MMP9 MMP13

5.70e-097126417033924
Pubmed

Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice.

MMP3 MMP8 MMP9 MMP13

5.70e-097126426163370
Pubmed

Secreted versus membrane-anchored collagenases: relative roles in fibroblast-dependent collagenolysis and invasion.

MMP8 MMP9 MMP13 MMP14

5.70e-097126419542530
Pubmed

Functional polymorphisms and haplotypes in the promoter of the MMP2 gene are associated with risk of nasopharyngeal carcinoma.

MMP1 MMP3 MMP9 MMP13

5.70e-097126417607721
Pubmed

Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors.

KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS4

5.70e-097126411169255
Pubmed

ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization.

MMP3 MMP8 MMP9 MMP13 MMP14

6.43e-0919126522014525
Pubmed

KIR haplotype content at the allele level in 77 Northern Irish families.

KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS4

1.14e-088126417200871
Pubmed

Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study.

MMP1 MMP3 MMP9 MMP13

1.14e-088126416356191
Pubmed

Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2.

MMP3 MMP9 MMP10 MMP14

1.14e-088126411865039
Pubmed

NullHap--a versatile application to estimate haplotype frequencies from unphased genotypes in the presence of null alleles.

KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS4

1.14e-088126418681957
Pubmed

Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains.

KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS4

2.04e-08912647749980
Pubmed

Alternatively spliced forms of human killer inhibitory receptors.

KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS4

2.04e-08912648662091
Pubmed

Differential expression of matrix metalloproteinases and their inhibitors in human and mouse lung development.

MMP20 MMP9 MMP14 MMP15

2.04e-089126416113801
Pubmed

Matrix metalloproteinases regulate morphogenesis, migration and remodeling of epithelium, tongue skeletal muscle and cartilage in the mandibular arch.

MMP3 MMP9 MMP10 MMP13

2.04e-08912649108368
Pubmed

ADAMTS: a novel family of extracellular matrix proteases.

ADAMTS13 ADAMTS5 ADAMTS12 ADAMTS7

3.39e-0810126411167130
Pubmed

Matrix metalloproteinase localisation by in situ-RT-PCR in archival human breast biopsy material.

MMP1 MMP3 MMP14

4.64e-083126317669621
Pubmed

Pancreatic lipase and its related proteins: where are we now?

PNLIP PNLIPRP1 PNLIPRP2

4.64e-083126338081381
Pubmed

Analysis of functional polymorphisms of metalloproteinase genes in persons with vascular dementia and Alzheimer's disease.

MMP1 MMP3 MMP9

4.64e-083126317077200
Pubmed

Gender specific associations between matrix metalloproteinases and inflammatory markers in post myocardial infarction patients.

MMP1 MMP3 MMP9

4.64e-083126318619594
Pubmed

Variations in matrix metalloproteinase-1, -3, and -9 genes and the risk of acute coronary syndrome and coronary artery disease in the Chinese Han population.

MMP1 MMP3 MMP9

4.64e-083126323377317
Pubmed

Natural haemozoin modulates matrix metalloproteinases and induces morphological changes in human microvascular endothelium.

MMP1 MMP3 MMP9

4.64e-083126321707906
Pubmed

Association of MMP3, MMP14, and MMP25 gene polymorphisms with cerebral stroke risk: a case-control study.

MMP25 MMP3 MMP14

4.64e-083126337986083
Pubmed

Pulmonary fibroblasts mobilize the membrane-tethered matrix metalloprotease, MT1-MMP, to destructively remodel and invade interstitial type I collagen barriers.

MMP8 MMP13 MMP14

4.64e-083126321840960
Pubmed

Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients.

KIR2DS2 KIR2DL2 KIR2DL3

4.64e-083126330696053
Pubmed

The association of MMP-1, -3 and -9 genotypes with the prognosis of HCV-related hepatocellular carcinoma patients.

MMP1 MMP3 MMP9

4.64e-083126318426080
Pubmed

Association of blood active matrix metalloproteinase-3 with carotid plaque score from a community population in Taiwan.

MMP1 MMP3 MMP9

4.64e-083126320609440
Pubmed

Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity.

PNLIP PNLIPRP1 PNLIPRP2

4.64e-08312631379598
Pubmed

Polymorphisms in the matrix metalloproteinase-1, 3, and 9 promoters and susceptibility to adult astrocytoma in northern China.

MMP1 MMP3 MMP9

4.64e-083126317502998
Pubmed

Reflux induces DNA strand breaks and expression changes of MMP1+9+14 in a human miniorgan culture model.

MMP1 MMP9 MMP14

4.64e-083126324075964
Pubmed

Synergistic effect of collagenase-1 (MMP1), stromelysin-1 (MMP3) and gelatinase-B (MMP9) gene polymorphisms in breast cancer.

MMP1 MMP3 MMP9

4.64e-083126328961241
Pubmed

Missense polymorphisms in matrix metalloproteinase genes and skin cancer risk.

MMP3 MMP8 MMP9

4.64e-083126319064570
Pubmed

MMP-9 genetic polymorphism may confer susceptibility to COPD.

MMP1 MMP3 MMP9

4.64e-083126327173221
Pubmed

West Nile virus-induced disruption of the blood-brain barrier in mice is characterized by the degradation of the junctional complex proteins and increase in multiple matrix metalloproteinases.

MMP3 MMP9 MMP13

4.64e-083126322398316
Pubmed

Increased alpha-synuclein aggregation following limited cleavage by certain matrix metalloproteinases.

MMP1 MMP3 MMP9

4.64e-083126319022250
Pubmed

Expression of matrix metalloproteinases 1, 3, and 9 in degenerated long head biceps tendon in the presence of rotator cuff tears: an immunohistological study.

MMP1 MMP3 MMP9

4.64e-083126321108787
Pubmed

Michelia alba extract attenuates UVB-induced expression of matrix metalloproteinases via MAP kinase pathway in human dermal fibroblasts.

MMP1 MMP3 MMP9

4.64e-083126322922035
Pubmed

Relationship between plasma matrix metalloproteinase levels, pulmonary function, bronchodilator response, and emphysema severity.

MMP1 MMP8 MMP9

4.64e-083126327313452
Pubmed

Cloning of an interleukin-4 inducible gene from cytotoxic T lymphocytes and its identification as a lipase.

PNLIP PNLIPRP1 PNLIPRP2

4.64e-08312632302735
Pubmed

Collagenase expression and activity in the stromal cells from giant cell tumour of bone.

MMP1 MMP8 MMP13

4.64e-083126319442604
Pubmed

Associations of killer cell immunoglobulin- like receptor genes with rheumatoid arthritis.

KIR2DS2 KIR2DL2 KIR2DL3

4.64e-083126322960345
Pubmed

MT1-MMP and ADAM10/17 exhibit a remarkable overlap of shedding properties.

ADAM10 ADAM17 MMP14

4.64e-083126335944080
Pubmed

Matrix metalloproteinase 1, 3, and 9 polymorphisms and esophageal squamous cell carcinoma risk.

MMP1 MMP3 MMP9

4.64e-083126325391977
Pubmed

MMP1, MMP9, MMP11 and MMP13 in melanoma and its metastasis - key points in understanding the mechanisms and celerity of tumor dissemination.

MMP1 MMP9 MMP13

4.64e-083126338527983
Pubmed

Killer immunoglobulin receptor genes and their HLA-C ligand are associated with Type 1 diabetes in an Eastern Indian population.

KIR2DL2 KIR2DL3 KIR2DS4

4.64e-083126326031759
Pubmed

Plasma metalloproteinase levels are dysregulated in signal transducer and activator of transcription 3 mutated hyper-IgE syndrome.

MMP3 MMP8 MMP9

4.64e-083126321872914
Pubmed

Features of vulnerable plaques and clinical outcome of UA/NSTEMI: Relationship with matrix metalloproteinase functional polymorphisms.

MMP1 MMP3 MMP9

4.64e-083126321232745
Pubmed

Evaluation of the genetic diversity of KIR genes in patients with endometrial cancer.

KIR2DS2 KIR2DL2 KIR2DS4

4.64e-083126338387251
Pubmed

Association of matrix metalloproteinase gene polymorphism with temporomandibular joint degeneration.

MMP1 MMP3 MMP9

4.64e-083126321244504
Pubmed

Extracellular matrix remodeling in Takayasu's arteritis: role of matrix metalloproteinases and adventitial inflammation.

MMP1 MMP3 MMP9

4.64e-083126322868188
Pubmed

Concentration of Selected Metalloproteinases and Osteocalcin in the Serum and Synovial Fluid of Obese Women with Advanced Knee Osteoarthritis.

MMP3 MMP9 MMP13

4.64e-083126335329213
Pubmed

Matrix metalloproteinase gene polymorphisms in patients with rheumatoid arthritis.

MMP1 MMP3 MMP9

4.64e-083126319504098
Pubmed

Polymorphism +17 C/G in matrix metalloprotease MMP8 decreases lung cancer risk.

MMP1 MMP8 MMP13

4.64e-083126319094243
Pubmed

Natural killer cell receptor variants and chronic hepatitis B virus infection in the Vietnamese population.

KIR2DL2 KIR2DL3 KIR2DS4

4.64e-083126332422377
Pubmed

Up-regulation of matrix metalloproteinases in a mouse model of chemically induced colitis-associated cancer: the role of microRNAs.

MMP3 MMP10 MMP13

4.64e-083126325742789
Pubmed

UVA-activated synthesis of metalloproteinases 1, 3 and 9 is prevented by a broad-spectrum sunscreen.

MMP1 MMP3 MMP9

4.64e-083126322092736
Pubmed

Plasma MMP1 and MMP8 expression in breast cancer: protective role of MMP8 against lymph node metastasis.

MMP1 MMP8 MMP13

4.64e-083126318366705
Pubmed

[Matrix metalloproteinase-1, -8, -9 and the risk of cardiovascular complications in patients with CHD before and after myocardial revascularization].

MMP1 MMP8 MMP9

4.64e-083126329215835
Pubmed

The Role of Matrix Metalloproteinases (MMP-8, MMP-9, MMP-13) in Periodontal and Peri-Implant Pathological Processes.

MMP8 MMP9 MMP13

4.64e-083126335163727
Pubmed

Matrix metalloproteinase-1, -3, and -9 gene polymorphisms and the risk of idiopathic dilated cardiomyopathy in a Chinese Han population.

MMP1 MMP3 MMP9

4.64e-083126318028894
InteractionMMP24 interactions

MMP20 MMP24 MMP1 MMP3 MMP8 MMP10 MMP13 MMP14 MMP15 MMP17

5.59e-181912610int:MMP24
InteractionMMP16 interactions

MMP20 MMP24 MMP1 MMP8 MMP10 MMP13 MMP14 MMP17

7.74e-14181268int:MMP16
InteractionMMP8 interactions

MMP20 MMP25 MMP24 MMP1 MMP8 MMP9 MMP13 MMP15

1.84e-12251268int:MMP8
InteractionMMP13 interactions

MYCBP2 ADAMTS5 MMP20 MMP24 MMP8 MMP10 MMP13 MMP14

1.30e-11311268int:MMP13
InteractionMMP11 interactions

MMP25 MMP24 MMP8 MMP9 MMP10 MMP13

4.75e-11121266int:MMP11
InteractionBCAN interactions

FBXO11 ADAMTS7 MMP1 MMP3 MMP8 MMP10 MMP13

2.27e-09361267int:BCAN
InteractionACAN interactions

ADAMTS5 MMP20 MMP1 MMP3 MMP8 MMP14

3.64e-09221266int:ACAN
InteractionMMP27 interactions

MMP24 MMP1 MMP8 MMP9 MMP10

3.95e-09111265int:MMP27
InteractionMMP7 interactions

MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13

1.38e-08461267int:MMP7
InteractionMMP1 interactions

MMP24 MMP1 MMP3 MMP8 MMP9 MMP17

1.05e-07371266int:MMP1
InteractionMMP3 interactions

MMP24 MMP1 MMP3 MMP9 MMP10 MMP14

1.46e-07391266int:MMP3
InteractionMMP20 interactions

MMP20 MMP24 MMP8 MMP13

2.97e-07101264int:MMP20
InteractionMMP10 interactions

MMP24 MMP3 MMP9 MMP10 MMP13

1.11e-06301265int:MMP10
InteractionMMP2 interactions

MMP25 MMP1 MMP8 MMP9 MMP10 MMP14 MMP17

1.22e-06871267int:MMP2
InteractionTIMP1 interactions

MMP1 MMP3 MMP9 MMP10 MMP14

4.87e-06401265int:TIMP1
InteractionCCL7 interactions

MMP1 MMP3 MMP13 MMP14

9.77e-06221264int:CCL7
InteractionTGFA interactions

NLRX1 SLC30A1 ADAM10 ADCY9 PWP2 ADAM17

1.77e-05871266int:TGFA
InteractionTIMP3 interactions

ADAMTS7 ADAM17 MMP3 MMP9 MMP13 MMP14

2.15e-05901266int:TIMP3
InteractionMMP17 interactions

MMP24 MMP1 MMP17

2.77e-05101263int:MMP17
InteractionMMP9 interactions

MMP1 MMP3 MMP8 MMP9 MMP10

6.25e-05671265int:MMP9
InteractionHAPLN1 interactions

MMP3 MMP9 MMP10

8.26e-05141263int:HAPLN1
InteractionEFHD2 interactions

MYCBP2 LRRK2 RDH12 ADAM10 WDFY4 GMPS

1.48e-041271266int:EFHD2
InteractionKISS1 interactions

MMP24 MMP9 MMP14

1.52e-04171263int:KISS1
InteractionGUCY1B1 interactions

MYCBP2 NOX5 USP28 ADCY9

2.11e-04471264int:GUCY1B1
InteractionRGMA interactions

CLK4 HIPK2 PPP1R16A

2.15e-04191263int:RGMA
Cytoband11q22.3

CWF19L2 MMP20 MMP1 MMP3 MMP8 MMP10 MMP13

3.49e-1144126711q22.3
CytobandEnsembl 112 genes in cytogenetic band chr11q22

CWF19L2 MMP20 MMP1 MMP3 MMP8 MMP10 MMP13

2.06e-081071267chr11q22
Cytoband19q13.4

KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS4

6.93e-0579126419q13.4
CytobandEnsembl 112 genes in cytogenetic band chr19q13

ZNF233 ZNF784 ANKRD27 ZNF587B ZNF814 FUT1 KIR2DL3 ZNF468 KIR2DS4 ZNF418 KLC3

4.64e-04119212611chr19q13
Cytoband16p13.3

ADCY9 C16orf89 MMP25 METRN UBN1

5.89e-04244126516p13.3
GeneFamilyEndogenous ligands|Matrix metallopeptidases

MMP23B MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

4.79e-242410013891
GeneFamilyCD molecules|Killer cell immunoglobulin like receptors

KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS4

2.54e-06181004620
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS13 ADAMTS5 ADAMTS12 ADAMTS7

3.20e-0619100450
GeneFamilyLipases|Arylacetamide deacetylase family

PNLIP PNLIPRP2 MGLL LIPC

5.97e-06221004464
GeneFamilyCDC like kinases

CLK4 CLK1

1.80e-0441002480
GeneFamilyADAM metallopeptidase domain containing|CD molecules

ADAM15 ADAM10 ADAM17

4.36e-0427100347
GeneFamilyWD repeat domain containing

DMXL2 MED16 WDFY4 DMXL1 UTP4 PWP2 PHIP

6.30e-042621007362
GeneFamilyX-linked mental retardation|RNA helicases

IFIH1 ASCC3

1.61e-031110021168
GeneFamilyUbiquitin specific peptidases

USP28 USP24 USP51

3.68e-03561003366
GeneFamilyAminoacyl tRNA synthetases, Class I

YARS2 CARS2

4.87e-03191002131
GeneFamilyGlycosyl transferases group 1 domain containing|Phosphatidylinositol glycan anchor biosynthesis

PIGN PIGO

5.94e-03211002680
GeneFamilyNLR family

NLRX1 NLRC5

8.36e-03251002666
CoexpressionNABA_ECM_REGULATORS

ADAM15 MMP23B ADAMTS13 ADAMTS5 MMP20 ADAM10 ADAMTS12 MMP25 MMP24 SERPINA4 ADAMTS7 ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

9.98e-2123812621M3468
CoexpressionNABA_ECM_REGULATORS

ADAM15 MMP23B ADAMTS13 ADAMTS5 MMP20 ADAM10 ADAMTS12 MMP25 MMP24 ADAMTS7 ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

3.28e-1924212620MM17062
CoexpressionNABA_MATRISOME_ASSOCIATED

ADAM15 MMP23B ADAMTS13 ADAMTS5 MMP20 ADAM10 ADAMTS12 MMP25 MMP24 SERPINA4 ADAMTS7 ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

7.69e-1175112621M5885
CoexpressionNABA_MATRISOME_ASSOCIATED

ADAM15 MMP23B ADAMTS13 ADAMTS5 MMP20 ADAM10 ADAMTS12 MMP25 MMP24 ADAMTS7 ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

3.94e-1073812620MM17058
CoexpressionNABA_MATRISOME

LAMB4 ADAM15 MMP23B ADAMTS13 ADAMTS5 MMP20 ADAM10 ZP3 ADAMTS12 MMP25 MMP24 SERPINA4 ADAMTS7 ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

6.68e-10102612623M5889
CoexpressionNABA_MATRISOME

ADAM15 MMP23B ADAMTS13 ADAMTS5 MMP20 ADAM10 ZP3 ADAMTS12 MMP25 MMP24 ADAMTS7 ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

1.46e-08100812621MM17056
CoexpressionHALLMARK_COAGULATION

RAPGEF3 MMP1 MMP3 MMP8 MMP9 MMP10 MMP14 MMP15

3.59e-071381268M5946
CoexpressionWILSON_PROTEASES_AT_TUMOR_BONE_INTERFACE_UP

USP24 ADAM10 MMP9 MMP13

2.32e-06201264M1792
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

DMXL2 MYCBP2 USP24 NBN MGLL ADAM10 ADCY9 GMPS TAOK3 PTPN13 ZNF451 ATAD2B ADAM17 ASCC3 PHIP

1.61e-0585612615M4500
CoexpressionSAUL_SEN_MAYO

MMP1 MMP3 MMP9 MMP10 MMP13 MMP14

3.08e-051241266M45803
CoexpressionGSE3982_EOSINOPHIL_VS_MAC_UP

NDST1 NLRX1 HIPK2 POU3F1 FBXO11 MMP25 CLK1

4.84e-051971267M5401
ToppCellE16.5-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRRK2 PAQR8 RDH12 MMP25 OSBPL2 MMP8 MMP9

2.61e-0715312576a2a2379238133ce0ad714af130ffe02dd317247
ToppCellE16.5-Immune-Immune_Myeloid-Granulocytic-Neutrophil|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRRK2 PAQR8 RDH12 MMP25 OSBPL2 MMP8 MMP9

2.61e-071531257faa442dd925b2b09919e93c492ccc3f19803ad24
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MGLL ADAMTS13 AKR7A2 MMP1 MMP3 MMP10 MMP14

9.74e-071861257360c3e9e5c3a943e68e6939b4a47821bfc75b553
ToppCellLPS-IL1RA-Myeloid-Myeloid_granulocytic-Neutrophils|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NOX5 NBN MMP1 MMP8 MMP9 MMP10

1.04e-0611812566053e19d040fb394f9c270361af07b0c5a4d47db
ToppCellLPS-IL1RA-Myeloid-Myeloid_granulocytic|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NOX5 NBN MMP1 MMP8 MMP9 MMP10

1.04e-061181256811e8521129914eef46785a4227c1860e77d9096
ToppCellLPS_IL1RA_TNF-Hematopoietic_Myeloid-Granulocytic_cells-Neutrophils|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

DMXL2 LRRK2 NBN MMP25 MMP1 MMP8 MMP9

1.53e-0619912578c2ab13b5fffbab3da37041a7000d6537fc4db09
ToppCellLPS_anti-TNF-Hematopoietic_Myeloid-Granulocytic_cells-Neutrophils|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

DMXL2 NBN MMP25 MMP1 MMP8 MMP9 MMP10

1.53e-06199125776aab03a51681f0ce3369887cf71a884b0998ec5
ToppCellLPS_anti-TNF-Hematopoietic_Myeloid-Granulocytic_cells|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

DMXL2 NBN MMP25 MMP1 MMP8 MMP9 MMP10

1.53e-0619912577227e6be56e9f333ee143e1418d22de32a4ca66a
ToppCellLPS_IL1RA_TNF-Hematopoietic_Myeloid-Granulocytic_cells|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

DMXL2 LRRK2 NBN MMP25 MMP1 MMP8 MMP9

1.58e-0620012571592ca96c59eb053d0f0915afb337db9f3a40c91
ToppCellfacs-Trachea-18m-Hematologic-myeloid-granulocyte-granulocyte_l8|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DMXL2 SH2D3C MMP25 MMP8 MMP9 TMUB2

5.46e-0615712565098675f64342c41c5ca3551b24962d10c83e64d
ToppCellfacs-Brain_Myeloid-Striatum_-18m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRK2 RDH12 MMP20 MMP25 MMP8 MMP9

5.46e-0615712569d4308312301cb922f156a7b6aededc9e1c62807
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

NDST1 NOX5 ADAM15 YARS2 CARS2 HYDIN

7.26e-061651256436ce4bc75e1ba4351c439ccad19f84ad5bcb92f
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

NDST1 NOX5 ADAM15 YARS2 CARS2 HYDIN

7.26e-061651256242bdb7654f415391fb8e9bdc06412c7eee9c97e
ToppCellLPS_only-Myeloid-Neutrophils|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DMXL2 NBN ADAM17 MMP1 MMP8 MMP9

1.16e-051791256d0a03e498afcfeb657037889685ecd77bed07e6c
ToppCellLPS_only-Myeloid-Neutrophils-Neutrophils|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DMXL2 NBN ADAM17 MMP1 MMP8 MMP9

1.16e-051791256d034651a5a355a58f5e15db627869f4feebdfe35
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRRK2 HIPK2 ADAM10 TBC1D16 LIPC HYDIN

1.23e-0518112566a6bd8e020cb0929b6ecdcb55d467ad24fecfaf0
ToppCellLPS-IL1RA+antiTNF-Myeloid-Neutrophils|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DMXL2 NBN MMP25 MMP1 MMP8 MMP9

1.27e-051821256243c783675df495ea4112dbf710712c44ea6b4f1
ToppCellLPS_only-Myeloid|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DMXL2 NBN ADAM17 MMP1 MMP8 MMP9

1.27e-051821256666ac86ee5f6fa9241ae8d80340743707e54b278
ToppCellLPS-IL1RA+antiTNF-Myeloid-Neutrophils-Neutrophils|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DMXL2 NBN MMP25 MMP1 MMP8 MMP9

1.27e-05182125618790a394dc32b3cef99cdbf826392c520e38b4a
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

DMXL2 MYCBP2 HEATR1 SLC30A1 ADAM10 BIRC6

1.39e-051851256a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

DMXL2 MYCBP2 HEATR1 SLC30A1 ADAM10 BIRC6

1.44e-0518612568571956890fc9894d766ba294a28e376b4aba428
ToppCell-Unknown-Endothelial-Myofibroblast| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

OMA1 LRRK2 USP24 ADAMTS5 ATAD2B CARS2

1.53e-0518812566468fa95ad0395395301115286f2d8c0df5d3882
ToppCell-Unknown-Endothelial| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

OMA1 LRRK2 USP24 ADAMTS5 ATAD2B CARS2

1.53e-0518812567a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell-Unknown| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

OMA1 LRRK2 USP24 ADAMTS5 ATAD2B CARS2

1.53e-0518812569cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCelldroplet-Limb_Muscle-nan-3m-Endothelial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM15 SH2D3C TNFAIP8L1 MGLL C16orf89 RAPGEF3

1.57e-051891256d52fc275976a625b014fa36f62ef07dddf1ffa43
ToppCelldroplet-Limb_Muscle-nan-3m-Endothelial-endothelial_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM15 SH2D3C TNFAIP8L1 MGLL C16orf89 RAPGEF3

1.57e-051891256199cec36fbbc1288771b9edf22143c34ab990af1
ToppCelldroplet-Limb_Muscle-nan-3m-Endothelial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM15 SH2D3C TNFAIP8L1 MGLL C16orf89 RAPGEF3

1.62e-0519012560a211e7dc515926b488f04c6248f6c7e61c2da87
ToppCellILEUM-non-inflamed-(8)_Activated_fibroblasts|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PIGN C16orf89 ADAMTS12 MMP1 MMP3 MMP14

1.62e-05190125639fa110d19c97c7cac99f5fb91b26bc08e2f3b42
ToppCelldroplet-Mammary_Gland-nan-18m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM15 SH2D3C TNFAIP8L1 MGLL C16orf89 RAPGEF3

1.72e-051921256945153c41dde6e90d103206955e1707b54eb0665
ToppCelldroplet-Mammary_Gland-nan-18m-Endothelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM15 SH2D3C TNFAIP8L1 MGLL C16orf89 RAPGEF3

1.72e-0519212566ab50579c63f31ca2cd41063a99b129f11c07510
ToppCellControl-Myeloid-TRAM2|Myeloid / Condition, Lineage and Cell class

TRIB2 NBN IFIH1 PDE4DIP NLRC5 MMP14

1.72e-051921256571fd71dad361a8b6c1bf9ad7184a89b3fbec667
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)-D122|Adult / Lineage, Cell type, age group and donor

DMXL2 HIPK2 WDFY4 TBC1D16 ADAM17 MFSD13A

1.77e-051931256cc1b6d3bf56e4a88f6fe23dd036a83cf5538c958
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CWF19L2 USP24 CLK1 ZNF451 ATAD2B NLRC5

2.10e-051991256f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellBiopsy_Control_(H.)-Epithelial-KRT5-/KRT17+|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

MMP24 SERPINA4 CYP7B1 MMP1 MMP15 KLC3

2.10e-0519912563b1f56c8b40bb36922a31d2d440a8c468a8aa3f1
ToppCellLPS_only-Hematopoietic_Myeloid-Granulocytic_cells-Neutrophils|LPS_only / Treatment groups by lineage, cell group, cell type

DMXL2 NBN MMP1 MMP8 MMP9 MMP10

2.16e-0520012563504aeba7b30cac9c428ba3871c072e2202752b4
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

MYCBP2 BIRC6 IFIH1 CLK1 ATAD2B PHIP

2.16e-05200125612f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellLPS_IL1RA-Hematopoietic_Myeloid-Granulocytic_cells-Neutrophils|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

DMXL2 NBN MMP25 MMP1 MMP8 MMP9

2.16e-052001256fd1b6db3c62f5a205b769ba0e61433dae6285b67
ToppCellLPS_IL1RA-Hematopoietic_Myeloid-Granulocytic_cells|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

DMXL2 NBN MMP25 MMP1 MMP8 MMP9

2.16e-0520012560b7573ec4e9c67c7d11dd8f5011a70bade30e930
ToppCellLPS_only-Hematopoietic_Myeloid-Granulocytic_cells|LPS_only / Treatment groups by lineage, cell group, cell type

DMXL2 NBN MMP1 MMP8 MMP9 MMP10

2.16e-052001256c5afebbc16024c60e84a67be81c78b0bfb73ec68
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_VISp_C1ql2_Cdh13|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

OMA1 POU3F1 ADAMTS13 LIPC MMP9

4.11e-0513612551f3000d5f105c87c80f8ae1dd2264bcd7f757a9c
ToppCelldroplet-Pancreas-Exocrine-24m-Epithelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PNLIP PNLIPRP1 PNLIPRP2 FUT1

4.52e-057012545720505ef03d65c73028616c808420e282823bde
ToppCellNS-critical-d_16-33-Myeloid-Monocyte-derived_Macrophage|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

IFIH1 NLRC5 MMP13 ZNF418 MFSD13A

7.19e-051531255859de35b24c5d7d73be1c213b90b43362ee2e0eb
ToppCell10x5'-blood-Lymphocytic_T_CD4-Trm_Th1/Th17|blood / Manually curated celltypes from each tissue

C9orf85 PIGN PTPN13 METRN PIGO

8.13e-051571255c99cb26d831c25038f2aa1b1c0f7ba52facb2e7a
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_monocytic-non-classical_monocyte|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NDST1 DMXL2 GDPD4 ADAMTS7 ASTN1

8.37e-051581255be9d7410f152071e3af971bc09181818070228a0
ToppCell5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.0.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RDH12 MMP25 MMP8 MMP9 MMP14

8.63e-0515912554b840da854390f8285c219314cff4434d7ffcacc
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Myeloid-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMXL2 RDH12 MMP25 MMP8 MMP9

8.63e-051591255a6093b230afdd4d91870d289c6ac91d1856666a3
ToppCell5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RDH12 MMP25 MMP8 MMP9 MMP14

8.63e-051591255d9e535cf9a0a2302268f2897b010dcecc6426e41
ToppCell5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RDH12 MMP25 MMP8 MMP9 MMP14

8.63e-05159125529999c87f5823f734e5cbf8ea8b729ec017db9b3
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_2|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

LRRK2 MMP8 MMP9 MMP14 KLC3

8.88e-051601255bb1bb3673059768c0ea0160d29fff127f3a4ecb4
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_2|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LRRK2 MMP8 MMP9 MMP14 KLC3

8.88e-05160125576f49b8b4450fa8acd36326bfa36a5d1f4bd95fb
ToppCellfacs-Lung-Endomucin_-18m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMXL2 RDH12 MMP25 MMP8 MMP9

9.15e-051611255e227f7b711475624cf80e77f235b1783d88d57b4
ToppCellfacs-Lung-Endomucin_-18m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMXL2 RDH12 MMP25 MMP8 MMP9

9.15e-0516112558280a029026c272cae9649b27575831b0dd4e242
ToppCellfacs-Marrow-Granulocytes-18m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIB2 RDH12 ADAMTS13 NXPE2 MMP9

9.70e-0516312557a04192710f55acf5a4681d5f09942358fdb02ff
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Basal_2|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

ADAMTS13 ADAMTS12 LIPC MMP3 MMP10

9.70e-051631255f21951e63188eb0c04675a8f81a0da495c26c007
ToppCelldroplet-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PNLIP PNLIPRP1 PNLIPRP2 ADAMTS12 FUT1

1.03e-041651255622aca1d49bd8c917b131e4f4959d9dba411d22b
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMXL2 RDH12 MMP25 MMP8 MMP9

1.15e-041691255a5964aef04093b460bbe29d5e2e7389f8fd2d46f
ToppCellfacs-BAT-Fat-18m-Myeloid-granulocyte|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMXL2 SH2D3C RDH12 MMP8 MMP9

1.15e-041691255d3e6c75e5eda133fb6535cfe6c6a1026641f26ac
ToppCelldroplet-Kidney-nan-18m-Epithelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMP23B ADAMTS5 ADAMTS12 ASTN1 MMP17

1.15e-04169125587116c33c5ca8cb1862e103e5607b1df4d264569
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMXL2 RDH12 MMP25 MMP8 MMP9

1.15e-041691255e0076aa61b4ef3f836f5750005d0469d3982eb6d
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PNLIPRP1 ADAMTS5 CYP7B1 MMP3 MMP14

1.15e-041691255031465190cd3623a25ef2b868daab8d932c8ff08
ToppCellfacs-BAT-Fat-3m-Myeloid-granulocyte|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMXL2 SH2D3C RDH12 MMP8 MMP9

1.18e-0417012558fd0a55266066a51266ab616c38c883e2680bcf4
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TRIB2 USP24 WDFY4 FARSA MMP13

1.18e-04170125532917888c3f1d54302675c1d4de1fd3b7c79af5f
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMXL2 LRRK2 MMP25 MMP8 MMP9

1.21e-041711255ab21f20ec041cbaacccbd7da4dccdb77ec8bc5c6
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMXL2 LRRK2 MMP25 MMP8 MMP9

1.21e-04171125597ad2cfff568a9d006ab1d2e6e00946ee4e3beb3
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CWF19L2 USP24 ZNF784 ANKRD27 METRN

1.25e-041721255a9e13aa36087170dadca421ba9de588e5a1cf715
ToppCellASK440-Epithelial-Transformed_epithelium|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

PIGN NDST1 ANKS6 SLC30A1 ZP3

1.25e-041721255df3800bcd9777d02900eba0cfc26ab73de8a1d95
ToppCellP15-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TNFAIP8L1 ADAM10 ASTN1 MMP9 MMP14

1.35e-04175125584d252f3e432231687613299bbea14978bb4b06b
ToppCellP15-Endothelial-lymphatic_endothelial_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TNFAIP8L1 ADAM10 ASTN1 MMP9 MMP14

1.35e-041751255a00c6fa9b33640710dd05a3799031147196f0986
ToppCellfacs-Skin-nan-18m-Epithelial-inner_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PNLIP PNLIPRP1 PNLIPRP2 ADAMTS5 SOD1

1.39e-041761255086197acbfec4ac0c15b7e9721871aaa9e32e219
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCBP2 ADAM10 PTPN13 ADAM17 MMP14

1.39e-0417612555e46a09a36b9645b1b1fcb0b64bd0898561af3a9
ToppCellE16.5-Immune-Immune_Myeloid-DC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MYCBP2 LRRK2 SLC30A1 PWP2 MMP8

1.43e-041771255235254c08b44c20ee3cb62dd2ca0c7e46a2587e3
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCBP2 ADAM10 PTPN13 ADAM17 MMP14

1.43e-04177125514fb8d182775dfd0e49aa7e4e12543a85b3b8bd6
ToppCellE16.5-Immune-Immune_Myeloid-DC-cDC2|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MYCBP2 LRRK2 SLC30A1 PWP2 MMP8

1.43e-041771255b59d9fcf0a4964ef2d6274b6021a69cf7d335e0a
ToppCellE16.5-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MYCBP2 LRRK2 SLC30A1 PWP2 MMP8

1.43e-041771255f55332fe7fc32c23892ccf08b6b4d5b1ffcc0d3f
ToppCell3'-Adult-SmallIntestine-Hematopoietic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYCBP2 LRRK2 MMP20 ADA2 WDFY4

1.46e-041781255da1695a936dbe3ca9ee3fb28ceb60511c47b35f8
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LRRK2 HIPK2 ADAM10 LIPC HYDIN

1.46e-041781255c20f050344a2e120e685e2a7fe36c6dfc1dc37b6
ToppCell3'-Adult-SmallIntestine-Hematopoietic-B_cells|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYCBP2 LRRK2 MMP20 ADA2 WDFY4

1.46e-041781255580fc1d45b82010c665a313b2e7a21e0116819ef
ToppCellfacs-Pancreas-Exocrine-18m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PNLIP PNLIPRP1 PNLIPRP2 MGLL FUT1

1.50e-041791255bbfbfb32773346080127055b5aafa36bbf7d0942
ToppCell10x5'-lymph-node_spleen-Myeloid_Mac-Intestinal_macrophages|lymph-node_spleen / Manually curated celltypes from each tissue

DMXL2 OBSL1 MMP9 MMP10 MMP14

1.54e-0418012557be7d7a6906fff6dbdecd9cb013d855aba4eda2a
ToppCellLPS-IL1RA-Myeloid-Neutrophils-Neutrophils|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DMXL2 NBN MMP1 MMP8 MMP9

1.54e-041801255c0c07937839652e01df10cc1e70aa005800ea6f6
ToppCellLPS-IL1RA-Myeloid-Neutrophils|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DMXL2 NBN MMP1 MMP8 MMP9

1.54e-041801255079c199425dd3c220f03c6dca1823946f07580a1
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRRK2 HIPK2 ADAM10 LIPC HYDIN

1.58e-041811255071f9bb5d39070cdc473d9b0e094d196bc702b56
ToppCellClub-club-8|World / Class top

PNLIPRP1 RHBG C16orf89 MMP3 SOD1

1.62e-0418212558111d917e588008d947021460ddf8f1e7ae1337a
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM15 MGLL NXPE2 C16orf89 RAPGEF3

1.62e-041821255506b63a233baf5e3baf924c13c88ab283b6e894f
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIB2 ZP3 LIPC USP51 KLC3

1.67e-041831255bc24145855bf4d027a8058bf92bc796c10f241bb
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

HIPK2 ADAM10 TBC1D16 LIPC HYDIN

1.67e-041831255cfae90c309622b5d499e62a3a8a8b9746478d28d
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIB2 ZP3 LIPC USP51 KLC3

1.67e-0418312554c325ee6da070513097a11445ec95b0415ffd8a2
ToppCellfacs-Thymus|facs / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PNLIP PNLIPRP1 RAPGEF3 LINGO4 KLC3

1.71e-04184125558beef66bbbde2479ec69dfef392d5941cedf230
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMP23B ADAMTS5 ADAMTS7 ASTN1 HYDIN

1.71e-0418412551c857126c0ea0671f0d60b048efca288d348d653
ToppCellfacs-Heart-RV|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM15 SH2D3C MGLL RAPGEF3 MMP15

1.75e-0418512557cf2b0db059605032bfae60cf1b93c4c62608f0c
ToppCelldroplet-Limb_Muscle-nan-18m-Endothelial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM15 SH2D3C TNFAIP8L1 MGLL C16orf89

1.94e-041891255a3f6ebd1622d36d114e42f6e0618d7b2fe8b9a2f
ToppCelldroplet-Limb_Muscle-nan-18m-Endothelial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM15 SH2D3C TNFAIP8L1 MGLL C16orf89

1.94e-041891255d86455cf20769d70d62e2c1dd92cbc93c67aada5
ToppCellfacs-Heart-LV-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SH2D3C MGLL C16orf89 RAPGEF3 MMP15

1.94e-041891255d424d2554595b2304219f7324406b401711af7c2
ToppCell(1)_Osterolineage_cells-(10)_OLC-1|World / Cell class and subclass of bone marrow stroma cells in homeostatis

MMP23B LIPC MMP9 MMP13 MMP14

1.94e-04189125546c5b975fb9d33017f2d9b7770d45a8bdf95baa2
ToppCellfacs-Heart-LV-3m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SH2D3C MGLL C16orf89 RAPGEF3 MMP15

1.94e-041891255393ec5954a12d6cf67bb435dcc34ff0b14c81e9f
ToppCellfacs-Heart-LV-3m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SH2D3C MGLL C16orf89 RAPGEF3 MMP15

1.94e-041891255bec57459ad4bab15b2532b57722549fec2e771fb
ToppCelldroplet-Limb_Muscle-nan-18m-Endothelial-endothelial_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM15 SH2D3C TNFAIP8L1 MGLL C16orf89

1.94e-04189125584036d1257f6b18f47cfc7ac5e6ed6ea3553c235
ToppCell3'_v3-lymph-node_spleen-Myeloid_Mac-Erythrophagocytic_macrophages|lymph-node_spleen / Manually curated celltypes from each tissue

OBSL1 MGLL MMP1 MMP3 MMP9

1.98e-04190125596c6078619e85f630c9754aca5d6066433e22836
ToppCelldroplet-Limb_Muscle-nan-21m-Endothelial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM15 SH2D3C MGLL C16orf89 RAPGEF3

1.98e-0419012551ff2295c9fc94ea21fff286706b739d0deb032d0
ToppCellfacs-Heart-RV-3m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM15 SH2D3C MGLL RAPGEF3 MMP15

1.98e-04190125589d1d686cc683206534e2157554d7d0df5d53497
ComputationalMMPs.

ADAM10 MMP1 MMP3 MMP9 MMP10 MMP13 MMP14 MMP15

9.02e-1321778MODULE_562
ComputationalGenes in the cancer module 210.

ADAM15 ADAM10 MMP1 MMP3 MMP9 MMP10 MMP13 MMP14

1.32e-1128778MODULE_210
ComputationalGenes in the cancer module 211.

MMP1 MMP3 MMP9 MMP10 MMP13

7.39e-0911775MODULE_211
ComputationalMetal ion (zinc) binding.

MMP1 MMP3 MMP9 MMP10 MMP13 MMP14

7.23e-0745776MODULE_280
ComputationalGenes in the cancer module 371.

MMP1 MMP3 MMP9 MMP10 MMP14

9.67e-0726775MODULE_371
ComputationalGenes in the cancer module 107.

MMP1 MMP3 MMP9 MMP10 MMP13 MMP14 MMP15

1.41e-0679777MODULE_107
ComputationalGenes in the cancer module 172.

LIPC MMP1 MMP3 MMP9 MMP13 MMP14 MMP15

5.25e-0696777MODULE_172
ComputationalCatabolic peptidases.

LIPC MMP1 MMP3 MMP9 MMP13 MMP14

4.02e-0589776MODULE_209
ComputationalMetal / Ca ion binding.

MMP1 MMP3 MMP9 MMP10 MMP13 MMP14

3.70e-04133776MODULE_324
ComputationalGenes in the cancer module 417.

PNLIP PNLIPRP2 LIPC

4.93e-0422773MODULE_417
ComputationalNeighborhood of SERPINI2

PNLIP PNLIPRP1 PNLIPRP2

7.26e-0425773GNF2_SERPINI2
ComputationalNeighborhood of SPINK1

PNLIP PNLIPRP1 PNLIPRP2

9.13e-0427773GNF2_SPINK1
ComputationalNeighborhood of PTPN9

NDST1 ADAM15 RXRB MVK

9.32e-0461774MORF_PTPN9
ComputationalNeighborhood of CNTN1

NDST1 ADAM15 RXRB MMP25 MVK

1.04e-03108775MORF_CNTN1
Drugmalolactomycin D

MMP23B MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

6.90e-223212513CID006449115
Drugdiacerein

MMP23B ADAMTS5 MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

3.19e-196312514CID000026248
DrugDA-125

MMP23B MMP20 MMP24 MMP1 MMP3 MMP8 MMP10 MMP13 MMP15 MMP17 TOP2B

6.28e-192612511CID000114758
DrugAC1L1GXT

MMP23B MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

1.71e-167412513CID000003890
DrugAC1NSU5S

NOX5 MMP23B TNFAIP8L1 MMP20 MMP24 SERPINA4 MMP1 MMP3 MMP8 MMP10 MMP13 MMP15 MMP17

2.06e-167512513CID005316299
Drugisoflavone

MMP23B TNFAIP8L1 MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17 PHIP TOP2B

3.19e-1615512516CID000072304
Drugmercuric acetate

MMP23B MMP20 MMP24 MMP1 MMP3 MMP8 MMP10 MMP13 MMP15 MMP17

4.72e-163012510CID000015337
Drug4-aminophenyl

MMP23B MMP20 ZP3 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP15 MMP17

7.49e-166212512CID000181201
DrugAC1L1DD6

MMP23B ADAMTS5 MMP20 ADAM10 MMP25 MMP24 ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

3.20e-1517912516CID000002299
DrugA0395

MMP23B MMP20 ADAM10 MMP24 ADAM17 MMP1 MMP3 MMP8 MMP10 MMP13 MMP15 MMP17

8.53e-157512512CID009906466
Drugcarvedilol

MMP23B TNFAIP8L1 MMP20 ADCY9 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

1.32e-1416112515CID000002585
Drugquercetin

LAMB4 NOX5 MMP23B TNFAIP8L1 MMP20 AKR7A2 MMP25 MMP24 FARSA SERPINA4 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17 PHIP TOP2B SOD1

2.06e-1448212522CID005280343
Drugquinacrine

NOX5 MMP23B TNFAIP8L1 MMP20 ADCY9 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17 TOP2B

2.48e-1424312517CID000000237
DrugMMI270

MMP24 ADAM17 MMP1 MMP3 MMP8 MMP13 MMP15 MMP17

2.75e-14181258CID000446504
Drugpirfenidone

MMP23B TNFAIP8L1 MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

3.19e-1413812514CID000040632
Drugmarimastat

TNFAIP8L1 MMP20 ADAM10 ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14

1.03e-136812511CID000119031
Drug1,10-phenanthroline

MMP23B MMP20 ADAM10 MMP25 MMP24 ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17 ENDOV SOD1

1.16e-1326712517CID000001318
Drugoxidized glutathione

NOX5 MMP23B MMP20 AKR7A2 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17 SOD1

1.34e-1322712516CID000000975
Drugtitanium

MMP23B TNFAIP8L1 MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

5.82e-1317012514CID000023963
DrugAC1L9M3B

MMP23B MMP20 MMP24 MMP1 MMP3 MMP8 MMP10 MMP13 MMP15 MMP17

1.23e-126112510CID000448562
DrugCGS 27023A

MMP1 MMP3 MMP8 MMP9 MMP13 MMP14

2.01e-1291256ctd:C097658
Drugdioxane

MMP23B MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17 TOP2B SOD1

3.74e-1127812515CID000031275
Druggluconate

MMP23B MMP20 ADCY9 AKR7A2 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

5.86e-1128712515CID000000604
DrugAC1L1HMM

NOX5 MMP23B TNFAIP8L1 NBN MMP20 ADCY9 MMP25 MMP24 OSBPL2 CYP7B1 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

5.95e-1151612519CID000004196
DrugAC1L1B55

NOX5 MMP23B TNFAIP8L1 MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17 PHIP TOP2B SOD1

6.01e-1145412518CID000001287
DrugPro-leu-gly

MMP24 ADAM17 MMP1 MMP8 MMP13 MMP15 MMP17

7.65e-11261257CID000169533
Drugenantio-PAF-C16

NOX5 MMP23B MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

7.74e-1124412514CID000002499
Drugraloxifene

MMP23B PPP1R13B TNFAIP8L1 MMP20 MMP24 PTPN13 OSBPL2 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP15 MMP17 TOP2B

9.86e-1135112516CID000005035
Drugglutathione reduced

NOX5 MMP23B MMP20 AKR7A2 MMP25 MMP24 CYP7B1 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17 PHIP TOP2B SOD1

1.06e-1053412519CID000000745
Drugdibutyryl cyclic 3',5'-AMP

LAMB4 NOX5 MMP23B TNFAIP8L1 MMP20 ADCY9 MMP25 MMP24 RAPGEF3 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17 TOP2B

2.44e-1056112519CID000002460
DrugMarimastat

MMP1 MMP3 MMP8 MMP9 MMP13

2.54e-1081255DB00786
DrugRo 32-3555

ADAM17 MMP1 MMP8 MMP9 MMP13

2.54e-1081255CID000193987
Drugperoxynitrite

NOX5 MMP23B MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17 SOD1

2.20e-0937312515CID000104806
Drug17-isoprogesterone

MMP23B PAQR8 HIPK2 TNFAIP8L1 NBN FBXO11 MMP20 ZP3 ADCY9 MMP25 MMP24 LIPC PTPN13 OSBPL2 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17 MVK SOD1

4.26e-09117012525CID000004920
Drugbeta-sulfone 7f

MMP1 MMP3 MMP8 MMP13

4.31e-0951254CID011526076
Drugalpha-sulfone 27e

MMP1 MMP3 MMP8 MMP13

4.31e-0951254CID011719408
DrugCTS-1027

MMP1 MMP3 MMP8 MMP13

4.31e-0951254CID003342298
DrugSC-276

MMP1 MMP3 MMP8 MMP13

4.31e-0951254CID009802768
Drugalpha-sulfone 35g

MMP1 MMP3 MMP8 MMP13

4.31e-0951254CID011705502
Drugbeta-sulfone 7d

MMP1 MMP3 MMP8 MMP13

4.31e-0951254CID011548264
Drugalpha-sulfone 27g

MMP1 MMP3 MMP8 MMP13

4.31e-0951254CID011561491
Drugbeta-sulfone 7e

MMP1 MMP3 MMP8 MMP13

4.31e-0951254CID011641261
Drugbeta-sulfone 7b

MMP1 MMP3 MMP8 MMP13

4.31e-0951254CID009867183
Drugalpha-sulfone 27d

MMP1 MMP3 MMP8 MMP13

4.31e-0951254CID011532911
Drugalpha-sulfone 27b

MMP1 MMP3 MMP8 MMP13

4.31e-0951254CID011697282
Drugbeta-sulfone 7c

MMP1 MMP3 MMP8 MMP13

4.31e-0951254CID011613649
Drugaldosterone

NOX5 MMP23B MMP20 MMP25 MMP24 UTP4 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

5.11e-0939712515CID000005839
DrugFN-439

ADAM17 MMP1 MMP3 MMP8 MMP13

5.72e-09131255CID000004648
Druggenistein

LAMB4 NOX5 ADAM15 MMP23B TNFAIP8L1 MMP20 MMP25 MMP24 SERPINA4 ADAMTS7 PWP2 ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17 PHIP TOP2B SOD1

8.23e-09111712524CID005280961
DrugAgeladine A

MMP1 MMP8 MMP9 MMP13 MMP14

8.86e-09141255ctd:C482289
DrugAC1L1G2K

ADAMTS5 ADAM17 MMP1 MMP3 MMP8 MMP9 MMP13 MMP14

2.02e-08841258CID000003498
Druglosartan

NOX5 MMP23B MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

2.20e-0837812514CID000003961
Drugprinomastat

MMP1 MMP3 MMP8 MMP9 MMP13 MMP14

2.38e-08331256CID000466151
Drugpolyethylenimine

PDE6A MGLL MMP24 ADAM17 MMP3 MMP9 MMP10 MMP14 MMP17

3.73e-081281259CID000009033
DrugNSC236997

NOX5 MMP23B MMP20 ADCY9 AKR7A2 MMP24 LIPC MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP15 MMP17 SOD1

4.51e-0853912516CID000005300
Druglatanoprost acid

MMP24 MMP1 MMP3 MMP9 MMP15 MMP17

7.99e-08401256CID006441636
Drugpseudococaine

MMP23B TNFAIP8L1 MMP20 ADCY9 MMP25 MMP24 ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

9.70e-0857012516CID000002826
DrugN-methylmesoporphyrin

MMP1 MMP3 MMP8 MMP9 MMP10 MMP13

1.08e-07421256CID000444708
Drugnoradrealine

NOX5 MMP23B TNFAIP8L1 MMP20 ADCY9 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17

1.09e-0757512516CID000000951
Drug17alpha-estradiol

NOX5 ADAM15 MMP23B TNFAIP8L1 MMP20 ADCY9 MMP25 MMP24 LIPC PTPN13 OSBPL2 PWP2 CYP7B1 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17 TOP2B SOD1

1.50e-07130312524CID000000450
Drugalpha-sulfone 21

MMP1 MMP3 MMP13

1.62e-0731253CID009822926
Drugdithizone

NBN MMP1 MMP8 MMP9 MMP13

1.80e-07241255CID000657262
Drugmagnesium

LAMB4 MMP23B MGLL MMP20 ADCY9 YARS2 GMPS MMP25 MMP24 FARSA ADAM17 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17 ENDOV TOP2B MVK SOD1

2.04e-07132512524CID000000888
DrugMatrix Metalloproteinase Inhibitors

MMP1 MMP3 MMP9 MMP14

2.77e-07111254ctd:D061965
Drugbenzoyl isothiocyanate

MMP1 MMP8 MMP9 MMP13

2.77e-07111254CID000068284
Drugformosanin C

MMP1 MMP3 MMP9 MMP14

5.96e-07131254ctd:C067584
Drugesculetin

NOX5 ADAMTS5 MMP1 MMP3 MMP13 MMP17

6.29e-07561256CID005281416
Drugcarbamoylphosphonic acid

MMP1 MMP3 MMP8

6.44e-0741253CID013879809
Drug3-hydroxypicolinic acid

MMP1 MMP3 MMP8

6.44e-0741253ctd:C049246
Drugalpha-sulfone 35h

MMP3 MMP8 MMP13

6.44e-0741253CID011684849
Drugalpha-sulfone 35a

MMP3 MMP8 MMP13

6.44e-0741253CID011633617
Drugalpha-sulfone 35c

MMP3 MMP8 MMP13

6.44e-0741253CID011533203
Drugalpha-sulfone 35d

MMP3 MMP8 MMP13

6.44e-0741253CID009954521
Drugacetate

NOX5 MMP23B MMP20 MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17 SOD1

1.06e-0659912515CID000000175
Drugethylnylestradiol

MMP23B TNFAIP8L1 NBN POU3F1 MMP20 RXRB ADCY9 MMP25 MMP24 LIPC OSBPL2 CYP7B1 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17 SOD1

1.17e-06125112522CID000003285
DrugMMP-3 inhibitor

MMP1 MMP3 MMP8

1.60e-0651253CID010549329
DrugPD-0200347

MMP1 MMP3 MMP13

1.60e-0651253ctd:C497431
Drugprinomastat

MMP3 MMP8 MMP13

1.60e-0651253ctd:C113282
Drug1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6''-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4,-dioxin

MMP1 MMP3 MMP13

1.60e-0651253ctd:C540360
DrugCGS 25966

MMP1 MMP3 MMP8

1.60e-0651253CID009821883
DrugAC1NRBJE

ADAM10 ADAM17 MMP1 MMP3 MMP8 MMP9 MMP13 MMP14

1.99e-061521258CID005288446
Drughydroxyl radical

NOX5 YARS2 MMP24 FARSA FUT1 MMP14 MMP15 MMP17 SOD1

2.11e-062061259CID000157350
Drugtricaprylin

PNLIP PNLIPRP1 PNLIPRP2 LIPC PHIP

2.94e-06411255CID000010850
DrugPz-plgpa

MMP1 MMP8 MMP9 MMP13

3.15e-06191254CID000152296
Drug4-aminoproline

MMP1 MMP3 MMP13

3.19e-0661253CID000124558
Drugvarespladib methyl

MMP1 MMP3 MMP9

3.19e-0661253ctd:C545088
Drug2-Amino-5-mercapto-1,3,4-thiadiazole

MMP1 MMP8 MMP9

3.19e-0661253CID002723847
DrugHydroxamate 12

MMP1 MMP3 MMP8

3.19e-0661253CID010594000
Drugdieckol

MMP1 MMP3 MMP13

3.19e-0661253ctd:C503840
Drugphosphocitrate

MMP1 MMP3 MMP8 MMP13

3.92e-06201254CID000123745
DrugPz-peptide

MMP1 MMP8 MMP9 MMP13

3.92e-06201254CID000161208
Drugmetrizamide

MMP1 MMP8 MMP9 MMP13

3.92e-06201254CID000035734
DrugAgronal

MMP1 MMP3 MMP8 MMP9 MMP13 MVK

4.86e-06791256CID000007511
Drugglycylvaline

MMP1 MMP3 MMP8 MMP9 MMP13

5.27e-06461255CID000097417
Drugtetracycline CMT-8

MMP8 MMP9 MMP13

5.56e-0671253ctd:C117153
DrugCGS 27023A Analog 51

MMP1 MMP3 MMP8

5.56e-0671253CID010594938
DrugAC1ND30P

MMP1 MMP8 MMP9 MMP13

5.87e-06221254CID004568793
DrugCbz-gplgp

MMP1 MMP8 MMP9 MMP13

5.87e-06221254CID000193354
Drugnitric oxide

NOX5 MMP23B TNFAIP8L1 MMP20 ADCY9 AKR7A2 GMPS MMP25 MMP24 MMP1 MMP3 MMP8 MMP9 MMP10 MMP13 MMP14 MMP15 MMP17 SOD1

6.40e-06107512519CID000145068
DrugAC1L4OCG

TNFAIP8L1 MMP1 MMP8 MMP9 MMP13

8.83e-06511255CID000102535
Diseaseinterstitial collagenase measurement

MMP20 MMP25 MMP1 MMP10 MMP13

5.25e-10111235EFO_0008193
Diseasethoracic aortic aneurysm (is_marker_for)

MMP1 MMP8 MMP9 MMP14

2.79e-07141234DOID:14004 (is_marker_for)
Diseasethoracic aortic aneurysm (biomarker_via_orthology)

ADAM10 ADAM17 MMP9

2.82e-0741233DOID:14004 (biomarker_via_orthology)
Diseaseosteoarthritis (is_marker_for)

ADAMTS5 MMP1 MMP3 MMP8 MMP9

3.41e-07351235DOID:8398 (is_marker_for)
Diseasematrix metalloproteinase 1 measurement

MMP20 MMP25 MMP10 MMP13

3.79e-07151234EFO_0010588
Diseaserheumatoid arthritis (is_marker_for)

LRRK2 ADAMTS5 MMP1 MMP3 MMP8 MMP9

4.49e-07691236DOID:7148 (is_marker_for)
Diseasematrix metalloproteinase 7 measurement

MMP20 MMP25 MMP13

3.90e-0681233EFO_0010591
Diseaseamyotrophic lateral sclerosis (is_marker_for)

LRRK2 MMP1 MMP9 SOD1

6.30e-06291234DOID:332 (is_marker_for)
Diseasearteriosclerosis (is_implicated_in)

MMP1 MMP3 MMP9 MMP13

8.29e-06311234DOID:2349 (is_implicated_in)
Diseaseabdominal aortic aneurysm (is_marker_for)

MMP8 MMP9 MMP14

8.30e-06101233DOID:7693 (is_marker_for)
DiseaseChronic Obstructive Airway Disease

RAPGEF3 MMP1 MMP9 MMP14

1.07e-05331234C0024117
DiseaseChronic Airflow Obstruction

RAPGEF3 MMP1 MMP9 MMP14

1.07e-05331234C1527303
Diseasedegenerative disc disease (biomarker_via_orthology)

ADAMTS5 MMP3 MMP13

1.14e-05111233DOID:90 (biomarker_via_orthology)
DiseaseAutoinflammatory disorder

ADA2 IFIH1 ADAM17 MVK

1.36e-05351234C3860213
DiseaseMetaphyseal anadysplasia

MMP9 MMP13

1.72e-0521232C0432226
Diseasevaricose veins (is_implicated_in)

MMP1 MMP9

1.72e-0521232DOID:799 (is_implicated_in)
Diseasethrombosis (is_implicated_in)

MMP1 MMP3 MMP9

3.10e-05151233DOID:0060903 (is_implicated_in)
Diseaseimmunoglobulin light chain amyloidosis (is_marker_for)

MMP1 MMP3

5.16e-0531232DOID:0080933 (is_marker_for)
Diseasemeningococcal meningitis (biomarker_via_orthology)

MMP9 MMP13

5.16e-0531232DOID:0080176 (biomarker_via_orthology)
DiseaseTakayasu's arteritis (is_marker_for)

MMP3 MMP9

5.16e-0531232DOID:2508 (is_marker_for)
Diseaseconjunctivochalasis (is_marker_for)

MMP3 MMP9

5.16e-0531232DOID:4250 (is_marker_for)
Diseasemyocardial infarction (is_implicated_in)

MMP1 MMP3 MMP9 MMP14 SOD1

6.07e-05991235DOID:5844 (is_implicated_in)
Diseasecongestive heart failure (biomarker_via_orthology)

ADAM17 MMP8 MMP9 MMP13 MMP14

8.78e-051071235DOID:6000 (biomarker_via_orthology)
Diseaseesophagus adenocarcinoma (is_implicated_in)

MMP1 MMP3 MMP14

8.90e-05211233DOID:4914 (is_implicated_in)
Diseasegastric ulcer (biomarker_via_orthology)

MMP3 MMP9 MMP13

8.90e-05211233DOID:10808 (biomarker_via_orthology)
Diseasecarotid artery disease (is_implicated_in)

MMP1 MMP8 MMP9

1.03e-04221233DOID:3407 (is_implicated_in)
Diseaseresponse to anti-thyroid drug

MMP20 MMP25

1.03e-0441232EFO_0007838
Diseasepsoriatic arthritis (is_marker_for)

MMP1 MMP3

1.03e-0441232DOID:9008 (is_marker_for)
Diseaseblood tin measurement

OMA1 SH2D3C NBN

1.52e-04251233EFO_0021530
Diseasematrilysin measurement

MMP20 MMP25

1.71e-0451232EFO_0008227
Diseaseanodontia (is_implicated_in)

MMP9 MMP13

1.71e-0451232DOID:13714 (is_implicated_in)
Diseaseadrenoleukodystrophy (is_marker_for)

MMP9 MMP10

1.71e-0451232DOID:10588 (is_marker_for)
Diseaselysophosphatidylethanolamine 16:0 measurement

NXPE2 ADCY9 LIPC

1.71e-04261233EFO_0010366
Diseaseosteoarthritis (is_implicated_in)

ADAMTS5 MMP3 MMP13

2.15e-04281233DOID:8398 (is_implicated_in)
Diseaseprimary biliary cholangitis (biomarker_via_orthology)

MMP3 MMP9 MMP13

2.15e-04281233DOID:12236 (biomarker_via_orthology)
Diseaseallergic contact dermatitis (biomarker_via_orthology)

MMP3 MMP9

2.56e-0461232DOID:3042 (biomarker_via_orthology)
DiseaseLipid Metabolism, Inborn Errors

LIPC CYP7B1

2.56e-0461232C0023772
Diseasestromelysin-2 measurement

MMP8 MMP10

2.56e-0461232EFO_0802095
Diseasecarotid stenosis (is_implicated_in)

MMP1 MMP3

2.56e-0461232DOID:13001 (is_implicated_in)
DiseaseAortic Diseases

MMP9 SOD1

2.56e-0461232C0003493
DiseaseDown syndrome (is_implicated_in)

MMP9 SOD1

2.56e-0461232DOID:14250 (is_implicated_in)
Diseaseatrial fibrillation (is_marker_for)

MMP1 MMP9 SOD1

3.21e-04321233DOID:0060224 (is_marker_for)
DiseaseAsthma

MMP1 MMP9 MMP10 SOD1

3.56e-04801234C0004096
Diseasematrix metalloproteinase 10 measurement

MMP8 MMP10

3.57e-0471232EFO_0010589
Diseasedegenerative disc disease (implicated_via_orthology)

MMP1 MMP13

3.57e-0471232DOID:90 (implicated_via_orthology)
Diseasebreast cancer (is_implicated_in)

NBN PTPN13 MMP1 MMP3 MMP8

4.24e-041501235DOID:1612 (is_implicated_in)
Diseasecrescentic glomerulonephritis (biomarker_via_orthology)

MMP3 MMP9

4.75e-0481232DOID:13139 (biomarker_via_orthology)
Diseasecognitive disorder (biomarker_via_orthology)

MMP3 MMP9

4.75e-0481232DOID:1561 (biomarker_via_orthology)
Diseasecataract (is_marker_for)

MMP3 SOD1

6.09e-0491232DOID:83 (is_marker_for)
DiseaseMarfan Syndrome, Type I

MMP9 SOD1

6.09e-0491232C4721845
DiseaseAortic Aneurysm, Abdominal

MMP9 MMP14

7.59e-04101232C0162871
Diseasepleural tuberculosis (is_marker_for)

ADA2 MMP9

7.59e-04101232DOID:106 (is_marker_for)
Diseaseglomerulosclerosis (biomarker_via_orthology)

MMP1 MMP9

7.59e-04101232DOID:0050851 (biomarker_via_orthology)
Diseasephosphatidylethanolamine measurement

PNLIPRP1 PNLIPRP2 ADAM10 LIPC MMP13

8.09e-041731235EFO_0010228
Diseasecoronary artery disease (is_implicated_in)

LIPC MMP1 MMP3 MMP9

8.28e-041001234DOID:3393 (is_implicated_in)
Diseaseglomerulosclerosis (implicated_via_orthology)

MMP1 MMP9

9.25e-04111232DOID:0050851 (implicated_via_orthology)
Diseasethoracic aortic aneurysm (is_implicated_in)

MMP1 MMP9

9.25e-04111232DOID:14004 (is_implicated_in)
DiseaseMarfan Syndrome

MMP9 SOD1

9.25e-04111232C0024796
Diseasepulmonary emphysema (is_implicated_in)

MMP1 MMP9

9.25e-04111232DOID:9675 (is_implicated_in)
Diseasediabetic angiopathy (is_marker_for)

MMP14 SOD1

1.11e-03121232DOID:11713 (is_marker_for)
Diseaseabdominal aortic aneurysm (is_implicated_in)

MMP1 MMP13

1.11e-03121232DOID:7693 (is_implicated_in)
Diseaseprostate specific antigen measurement

PLAC1 MMP20 MMP25 LIPC PHIP

1.17e-031881235EFO_0004624
Diseaseliver cirrhosis (implicated_via_orthology)

UTP4 MMP1

1.30e-03131232DOID:5082 (implicated_via_orthology)
Diseasehypothyroidism (implicated_via_orthology)

LIPC SOD1

1.30e-03131232DOID:1459 (implicated_via_orthology)
Diseasehypertension (is_marker_for)

MMP1 MMP9 SOD1

1.42e-03531233DOID:10763 (is_marker_for)
Diseasesystemic scleroderma (is_marker_for)

ADAMTS13 MMP1 MMP3

1.42e-03531233DOID:418 (is_marker_for)
Diseaseskin melanoma (is_implicated_in)

MMP1 MMP9

1.52e-03141232DOID:8923 (is_implicated_in)
Diseaseabdominal aortic aneurysm (biomarker_via_orthology)

MMP3 MMP14

1.52e-03141232DOID:7693 (biomarker_via_orthology)
Diseaseatrial fibrillation (is_implicated_in)

MMP1 MMP3

1.52e-03141232DOID:0060224 (is_implicated_in)
Diseaseautosomal dominant polycystic kidney disease (is_marker_for)

MMP1 MMP9

1.52e-03141232DOID:898 (is_marker_for)
Diseaseintracranial aneurysm (is_marker_for)

MMP9 MMP14

1.52e-03141232DOID:10941 (is_marker_for)
Diseaselevel of Phosphatidylethanolamine (18:1_18:1) in blood serum

ADAM10 LIPC

1.52e-03141232OBA_2045142
Diseasefree cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement

ADAM10 BIRC6 LIPC NLRC5 MMP9 MVK

1.74e-033031236EFO_0004612, EFO_0020945
Diseasequinate measurement

NOX5 LRRK2

1.75e-03151232EFO_0021167
Diseaseresponse to platinum based chemotherapy, magnesium measurement

TBC1D16 ENDOV

1.75e-03151232EFO_0004647, EFO_0004845
DiseaseAlzheimer's disease (biomarker_via_orthology)

ADAM10 ADAM17 SOD1

1.85e-03581233DOID:10652 (biomarker_via_orthology)
Diseasecholesteatoma of middle ear (is_marker_for)

MMP1 MMP9

1.99e-03161232DOID:10964 (is_marker_for)
Diseaselevel of Phosphatidylethanolamine (16:0_20:4) in blood serum

ADAM10 LIPC

1.99e-03161232OBA_2045137
Diseaseretinopathy

SLC30A1 CYP7B1

2.25e-03171232EFO_0003839
Diseaseocular hypertension (biomarker_via_orthology)

MMP9 SOD1

2.25e-03171232DOID:9282 (biomarker_via_orthology)
Diseasematrix metalloproteinase 12 measurement

MMP3 MMP13

2.52e-03181232EFO_0010590
DiseaseOral Submucous Fibrosis

MMP1 MMP9

2.52e-03181232C0029172
Diseaselevel of Sphingomyelin (d34:1) in blood serum

USP24 LIPC

2.52e-03181232OBA_2045175
Diseaselipid measurement, high density lipoprotein cholesterol measurement

OBSL1 ADAM10 LIPC NLRC5 MMP9 MVK

2.66e-033301236EFO_0004529, EFO_0004612
Diseasemyocardial infarction (implicated_via_orthology)

MMP1 MMP9 MMP13

2.67e-03661233DOID:5844 (implicated_via_orthology)
Diseaseblood metabolite measurement

GMPS PPP1R16A

2.81e-03191232EFO_0005664
Diseaseesterified cholesterol measurement, high density lipoprotein cholesterol measurement

OBSL1 LIPC

2.81e-03191232EFO_0004612, EFO_0008589
Diseaselevel of Phosphatidylethanolamine (18:0_20:4) in blood serum

ADAM10 LIPC

2.81e-03191232OBA_2045140
DiseaseProstate cancer, familial

NBN ELAC2 MMP14

3.03e-03691233C2931456
Diseasewhite matter lesion progression measurement

OMA1 PAQR8 MMP3

3.29e-03711233EFO_0007746
DiseaseContact Dermatitis

MMP8 MMP10 SOD1

3.29e-03711233C0011616
DiseaseContact hypersensitivity

MMP8 MMP10 SOD1

3.29e-03711233C0162351
DiseaseLiver diseases

CYP7B1 MMP9 SOD1

3.42e-03721233C0023895
DiseaseLiver Dysfunction

CYP7B1 MMP9 SOD1

3.42e-03721233C0086565
DiseaseRetinal Degeneration

RDH12 SOD1

3.44e-03211232C0035304
Diseaseosteoarthritis (biomarker_via_orthology)

ADAMTS5 MMP13

3.44e-03211232DOID:8398 (biomarker_via_orthology)
DiseaseHIV-1 infection, Susceptibility to viral and mycobacterial infections

CYP7B1 ADAM17

3.44e-03211232EFO_0000180, Orphanet_391311
Diseaseperiodontitis (biomarker_via_orthology)

MMP3 MMP13

3.44e-03211232DOID:824 (biomarker_via_orthology)
Diseaseupper aerodigestive tract neoplasm

HEATR1 BIRC6 ADAMTS7 CYP7B1 MVK

3.76e-032461235EFO_0004284
Diseaseidiopathic pulmonary fibrosis (is_marker_for)

MMP1 MMP3

4.12e-03231232DOID:0050156 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
LVETGFHHVGHAGLE

nan

41

Q8N976
FHHVGHAGLELLTSS

nan

46

Q8N976
HHSQLQGAHGDAVIL

AKR7A2

301

O43488
LVETGFHHVAHAGLE

C16orf89

371

Q6UX73
HLTKHENFHGGLDAI

BIRC6

3016

Q9NR09
VSHITFAHEVGHNFG

ADAM10

376

O14672
IAHELGHSLGLDHDL

ADAM15

346

Q13444
GLHAAFTVAHEIGHL

ADAMTS5

401

Q9UNA0
FTVAHEIGHLLGLSH

ADAMTS5

406

Q9UNA0
HDLELGHTHGTLATA

CALHM1

256

Q8IU99
SLIHGFTCHDHGATV

DMXL2

2891

Q8TDJ6
LTGHGLIHSFKSEHA

DMXL2

2971

Q8TDJ6
FGPEHAQVLSGHLLH

DMXL1

1481

Q9Y485
AGHHHIVKFLLDFGV

PPP1R13B

931

Q96KQ4
GTLLFHIHHQDGAPS

ASTN1

116

O14525
AHELGHSFGIQHDGK

ADAMTS12

391

P58397
TIAHEIGHSFGLEHD

ADAMTS13

221

Q76LX8
VAHELGHSFGIQHDG

ADAMTS7

386

Q9UKP4
FEHHGHICIVFELLG

CLK1

231

P49759
VAVHELGHALGLEHS

MMP14

236

P50281
AHEFGHSLGLAHSSD

MMP8

216

P22894
HLIGEHHDGVSKANF

KIR2DS2

71

P43631
AGLHVLLFGLAASAH

NOX5

246

Q96PH1
GHHELVALLLQHGAS

ANKRD27

821

Q96NW4
AHELGHSLGLFHSAN

MMP10

216

P09238
DGHIHRLFIHGVILA

OBSL1

1501

O75147
ETHLGVNHLGHFLLT

RDH12

141

Q96NR8
VHELGHALGLEHSSD

MMP24

281

Q9Y5R2
AVHEFGHALGLGHSS

MMP25

231

Q9NPA2
HEFGHALGLDHSSVP

MMP9

401

P14780
HLIGEHHDGVSKANF

KIR2DL2

71

P43627
HLIGEHHDGVSKANF

KIR2DS4

71

P43632
GTVHPHLAAAAAAAH

HIPK2

1081

Q9H2X6
MGLDLLVFAHDHVGH

MGLL

66

Q99685
LVFAHDHVGHGQSEG

MGLL

71

Q99685
SDFVIHGIIHGVTHD

METRN

186

Q9UJH8
HLIGEHHDGVSKANF

KIR2DL3

71

P43628
SNVHVIGHSLGAHAA

PNLIP

161

P16233
SVRFDSIGGLSHHIH

ATAD2B

396

Q9ULI0
VAVHELGHALGLEHS

MMP15

256

P51511
AAHEIGHSLGLFHSA

MMP3

216

P08254
HLIGHSLGAHVAGEA

PNLIPRP1

166

P54315
AHEFGHSLGLDHSKD

MMP13

221

P45452
LHGSSILERHHLEFG

PDE6A

621

P16499
GLHGGFAHVIEDQHK

CWF19L2

826

Q2TBE0
GFHARLVHQGAAHAG

POU3F1

111

Q03052
GLHHALHEDGHEAQL

POU3F1

186

Q03052
GHAHAGGLHAAAAHL

POU3F1

216

Q03052
HLGADAGLHAALHAT

NDST1

251

P52848
HVHLIGYSLGAHVSG

LIPC

161

P11150
HAVHFLNESGVLLHF

LRRK2

1571

Q5S007
AVEHGAHGLETDIHL

GDPD4

221

Q6W3E5
ALRAEHHGLAGHLAE

KLC3

36

Q6P597
HHGLAGHLAEALAGQ

KLC3

41

Q6P597
AAAGSHLLFVLHGLE

NLRX1

231

Q86UT6
HGPFHELTVHEAACA

CYHR1

176

Q6ZMK1
AQIHDFVLGGGLHSH

HSPA7

331

P48741
LAHLASGLGHCHHLE

NLRC5

1511

Q86WI3
GLALAFHDGSVHIVH

MED16

381

Q9Y2X0
DIVGHGHQIFHAFLS

PAQR8

276

Q8TEZ7
ALVDHIQFGDCHIGH

HYDIN

3651

Q4G0P3
HHHYEGAVVILDAGA

GMPS

21

P49915
IHHGRDVGVFTFDHG

FBXO11

451

Q86XK2
LHGYQLHVDLHSGGV

FBXO15

351

Q8NCQ5
EVGVKAHHLIGAGHS

IFIH1

746

Q9BYX4
GFDLVGHEDTGHSLH

ADA2

321

Q9NZK5
LLHGCIHAIGVHLFV

ADCY9

286

O60503
FGHVSVAHLLLDHGA

ANKS6

121

Q68DC2
AGAFVDHHHPSGEQL

ANKS6

166

Q68DC2
QFGHTFGHLTHDALG

FAM166B

251

A8MTA8
GESHAHSHVLVDSLG

LAMB4

696

A4D0S4
VHEDLEIGAHHLGFL

CYP7B1

276

O75881
HHHALLLLGTVAGIF

HEATR1

1301

Q9H583
LHHRGFGVACHLGVL

ENDOV

131

Q8N8Q3
HHGHVCIVFELLGLS

CLK4

231

Q9HAZ1
GTTGAHHHAQLIFVF

C9orf85

146

Q96MD7
GFLTLVDLHHHALLA

MFSD13A

136

Q14CX5
SLEDVHVIGHSLGAH

PNLIPRP2

161

P54317
HVIGHSLGAHTAAEA

PNLIPRP2

166

P54317
AAHAFHGLTAFHLLD

LINGO4

316

Q6UY18
VVAHIGLVEHHLFAL

PTPN13

601

Q12923
HEFGHALGLAHSTDP

MMP20

226

O60882
HIHQDSFPHGLGLSI

FUT1

26

P19526
NDVCVHFHELHLGLG

PLAC1

46

Q9HBJ0
LHIVQLSGGSFKHLH

UTP4

461

Q969X6
IHSGGIDLAFPHHEN

CARS2

271

Q9HA77
DGSHIKGLLINFIHH

TOP2B

566

Q02880
NFLAHGVLPDSGHLH

FARSA

211

Q9Y285
HIIGGSDLIAHHARK

NBN

701

O60934
FDHHGAGIFKTHVLL

NXPE2

386

Q96DL1
AVHEFGHAIGLSHVA

MMP17

246

Q9ULZ9
GHAIGLSHVAAAHSI

MMP17

251

Q9ULZ9
NLHRVAAHELGHSLG

MMP1

211

P03956
ALHHCFDGPTGELAH

MMP23B

156

O75900
SLHVGHLLALLGLFH

YARS2

86

Q9Y2Z4
ALSHGQLHVEHDGES

SERPINA4

16

P29622
HAPLDHGATLLHVAA

PPP1R16A

226

Q96I34
AITHGALHGLAYLHS

TAOK3

126

Q9H2K8
KIVHFSVGHDGSHAL

MYCBP2

581

O75592
DLGHVALSLVHAGAL

HERC2P3

176

Q9BVR0
GNLHLHEDAHAGIGL

TEX45

111

Q8NA69
HEDAHAGIGLSNAHA

TEX45

116

Q8NA69
IKGLTEGLHGFHVHE

SOD1

36

P00441
GHEIAHAVLGHAAEK

OMA1

326

Q96E52
HSEGLNHDFLFHGSI

OSBPL2

186

Q9H1P3
LHVHRNSAHSAGVGA

RXRB

401

P28702
LVTTHELGHNFGAEH

ADAM17

401

P78536
TLAFGIGMHHAGLHE

ASCC3

1611

Q8N3C0
GERGHFGVQILHHFI

LINC02915

156

Q8N8G6
AALLHHFHVEPAGGS

RAPGEF3

436

O95398
HAHGLQELEFIRGHS

ZNF451

111

Q9Y4E5
LFAVINHHGTLESGH

USP51

651

Q70EK9
AVFVSHLHADHHTGL

ELAC2

541

Q9BQ52
GQHFACTDSHGHLLI

PHIP

526

Q8WWQ0
LVQGFLHSFHGGHIH

RHBG

106

Q9H310
LHGEHAVVHGKVALA

MVK

16

Q03426
HLLVTGFASGIFHLH

PWP2

301

Q15269
EGDHVFRAVHLHSGE

TRIB2

71

Q92519
HFHHGGLDKLSDVFQ

TBC1D16

336

Q8TBP0
GHLVSEGVLLFGHQH

WDFY4

2401

Q6ZS81
TSVLHLGHVDHLVAG

TMUB2

76

Q71RG4
LHAVLVHEGQANAGH

USP28

586

Q96RU2
FFLHLLGIDTNGHAH

PIGN

206

O95427
HSLFNGALDQAHGHV

SLC30A7

176

Q8NEW0
LGDILHVADHQGTHH

ZNF587B

101

E7ETH6
SHFGNLKVHERIHTG

ZNF442

526

Q9H7R0
HGASFHGHLLTLNVT

USP24

951

Q9UPU5
LVGVIVHSGQAHAGH

USP24

1956

Q9UPU5
SFHHGLGHSLLAGLH

UBN1

1081

Q9NPG3
LGDILHLADHQGTHH

ZNF418

91

Q8TF45
GKGFHHSLDFDIHCV

ZNF233

376

A6NK53
VLIAHFLGVDHCGHK

PIGO

226

Q8TEQ8
EAARTVAHHGGLYHT

SH2D3C

781

Q8N5H7
VNVLGLCLFHHHSGF

SLC30A1

126

Q9Y6M5
HLGDAAHLQAEIHTG

ZP3

191

P21754
TGTLHRQASHHIGEF

ZNF468

71

Q5VIY5
LHGGDSHSVLYTLHH

ZFYVE26

436

Q68DK2
TAKSHGRINHVFGHL

TNFAIP8L1

136

Q8WVP5
LGDILHVADHQGTHH

ZNF814

101

B7Z6K7
AIGVGSFARHHHHSA

ZIC2

11

O95409
LVSELLFHEHGHLAG

ZNF784

76

Q8NCA9
SFANKHGRHVIGHID

PDE4DIP

2171

Q5VU43