Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	low voltage-gated calcium channel activity	CACNA1I CACNA1H	5.88e-05	3	89	2	GO:0008332
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN8A CACNA1I CACNA1H	2.07e-04	26	89	3	GO:0005248
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN8A CACNA1I CACNA1H	4.86e-05	17	89	3	GO:0001518
GeneOntologyCellularComponent	ER to Golgi transport vesicle membrane	MCFD2 HLA-E SREBF1 SREBF2	1.60e-04	64	89	4	GO:0012507
GeneOntologyCellularComponent	sodium channel complex	SCN8A CACNA1I CACNA1H	2.52e-04	29	89	3	GO:0034706
GeneOntologyCellularComponent	cation channel complex	SCN8A CACNA1I CACNA1H CCDC51 RYR1 KCNH4	5.06e-04	235	89	6	GO:0034703
Domain	ARM-type_fold	RELCH URB1 WAPL NOM1 UBR4 RTTN LTN1 USP24 CKAP5 DIAPH1 FRYL IPO4 SYMPK	7.50e-09	339	89	13	IPR016024
Domain	ARM-like	RELCH SETX RTTN LTN1 CKAP5 FRYL IPO4 SYMPK	4.42e-05	270	89	8	IPR011989
Domain	VDCC_T_a1	CACNA1I CACNA1H	6.72e-05	3	89	2	IPR005445
Domain	HEAT_type_2	RELCH CKAP5 IPO4	6.78e-05	17	89	3	IPR021133
Domain	Ion_trans_dom	SCN8A CACNA1I CACNA1H RYR1 KCNH4	2.14e-04	114	89	5	IPR005821
Domain	Ion_trans	SCN8A CACNA1I CACNA1H RYR1 KCNH4	2.14e-04	114	89	5	PF00520
Domain	GST_alpha	GSTA5 GSTA4	2.22e-04	5	89	2	IPR003080
Domain	DHC_N1	DNAH2 DNAH11	6.17e-04	8	89	2	PF08385
Domain	Dynein_heavy_dom-1	DNAH2 DNAH11	6.17e-04	8	89	2	IPR013594
Domain	-	RELCH RTTN CKAP5 FRYL IPO4 SYMPK	6.74e-04	222	89	6	1.25.10.10
Domain	VDCCAlpha1	CACNA1I CACNA1H	9.86e-04	10	89	2	IPR002077
Domain	GST_C_3	GSTA5 GSTA4	9.86e-04	10	89	2	PF14497
Domain	TPR_REGION	TTC7A IFT140 TTC7B DNAH2 PRMT9	1.16e-03	165	89	5	PS50293
Domain	TPR	TTC7A IFT140 TTC7B DNAH2 PRMT9	1.16e-03	165	89	5	PS50005
Domain	HEAT	CKAP5 IPO4 SYMPK	1.55e-03	48	89	3	PF02985
Domain	Dynein_heavy_chain_D4_dom	DNAH2 DNAH11	1.97e-03	14	89	2	IPR024317
Domain	Dynein_HC_stalk	DNAH2 DNAH11	1.97e-03	14	89	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH2 DNAH11	1.97e-03	14	89	2	IPR013602
Domain	DHC_N2	DNAH2 DNAH11	1.97e-03	14	89	2	PF08393
Domain	MT	DNAH2 DNAH11	1.97e-03	14	89	2	PF12777
Domain	AAA_8	DNAH2 DNAH11	1.97e-03	14	89	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH2 DNAH11	1.97e-03	14	89	2	IPR011704
Domain	AAA_5	DNAH2 DNAH11	1.97e-03	14	89	2	PF07728
Domain	DHC_fam	DNAH2 DNAH11	2.26e-03	15	89	2	IPR026983
Domain	Dynein_heavy_dom	DNAH2 DNAH11	2.26e-03	15	89	2	IPR004273
Domain	Dynein_heavy	DNAH2 DNAH11	2.26e-03	15	89	2	PF03028
Domain	Channel_four-helix_dom	SCN8A CACNA1I CACNA1H	2.54e-03	57	89	3	IPR027359
Domain	-	SCN8A CACNA1I CACNA1H	2.54e-03	57	89	3	1.20.120.350
Domain	HEAT	CKAP5 IPO4 SYMPK	2.67e-03	58	89	3	IPR000357
Domain	HEAT_REPEAT	RELCH CKAP5 IPO4	4.55e-03	70	89	3	PS50077
Domain	GST_N	GSTA5 GSTA4	4.87e-03	22	89	2	PF02798
Domain	GST_NTER	GSTA5 GSTA4	4.87e-03	22	89	2	PS50404
Domain	Acetyltransf_1	NAT9 NAA20	5.32e-03	23	89	2	PF00583
Domain	TPR-contain_dom	TTC7A IFT140 TTC7B PRMT9	5.76e-03	150	89	4	IPR013026
Domain	GNAT	NAT9 NAA20	6.27e-03	25	89	2	PS51186
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	URB1 EPPK1 NUP85 SPHK1 UBR4 RTTN SCN8A SREBF1 FBXL12 CACNA1H FRYL IDUA MMP17 RYR1 SYMPK	1.77e-07	1105	91	15	35748872
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	PHKA1 TTC7B UBP1 TMEM121B UBR4 SCN8A USP24 LRRC8B PHF10 DMXL1	4.92e-07	475	91	10	31040226
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	RAB18 DYM EPPK1 HYOU1 UBR4 HLA-E LTN1 CPNE1 PABPC1L IPO4 MVP	1.04e-06	647	91	11	26618866
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	URB1 EPPK1 HYOU1 UBR4 USP24 CKAP5 WDR18 FRYL IPO4 MVP SYMPK	1.14e-06	653	91	11	22586326
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	WAPL SETX EPPK1 ANAPC2 USP24 CKAP5 DIAPH1 WDR18 MVP SYMPK	3.04e-06	582	91	10	20467437
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	URB1 VRK2 WAPL HYOU1 NUP85 UBR4 ANAPC2 USP24 DNAH2 SREBF2 IPO4 SYMPK	6.44e-06	942	91	12	31073040
Pubmed	Human hepatic lipase overexpression in mice induces hepatic steatosis and obesity through promoting hepatic lipogenesis and white adipose tissue lipolysis and fatty acid uptake.	LIPC SREBF1	6.77e-06	2	91	2	29244870
Pubmed	Sterol regulatory element-binding proteins are regulators of the sodium/iodide symporter in mammary epithelial cells.	SREBF1 SREBF2	6.77e-06	2	91	2	27614840
Pubmed	Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane.	SREBF1 SREBF2	6.77e-06	2	91	2	8626610
Pubmed	A T-type calcium channel required for normal function of a mammalian mechanoreceptor.	CACNA1I CACNA1H	6.77e-06	2	91	2	12808460
Pubmed	Role of altered renal lipid metabolism and the sterol regulatory element binding proteins in the pathogenesis of age-related renal disease.	SREBF1 SREBF2	6.77e-06	2	91	2	16316337
Pubmed	Effects of a catechin-free fraction derived from green tea on gene expression of enzymes related to lipid metabolism in the mouse liver.	SREBF1 SREBF2	6.77e-06	2	91	2	22361881
Pubmed	Impaired regulation of sterol regulatory element binding protein 2 in cholesterol gallstone-susceptible mice.	SREBF1 SREBF2	6.77e-06	2	91	2	15062879
Pubmed	Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes.	SREBF1 SREBF2	6.77e-06	2	91	2	12177166
Pubmed	Association of sterol regulatory element-binding transcription factor gene polymorphisms with ischaemic stroke.	SREBF1 SREBF2	6.77e-06	2	91	2	22429355
Pubmed	Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study.	SREBF1 SREBF2	6.77e-06	2	91	2	28367087
Pubmed	Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice.	CACNA1I CACNA1H	6.77e-06	2	91	2	25071191
Pubmed	SREBP-1c gene polymorphism is associated with increased inhibition of cholesterol-absorption in response to ezetimibe treatment.	SREBF1 SREBF2	6.77e-06	2	91	2	18072016
Pubmed	Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model.	SREBF1 SREBF2	6.77e-06	2	91	2	16879892
Pubmed	Spatial distribution and function of sterol regulatory element-binding protein 1a and 2 homo- and heterodimers by in vivo two-photon imaging and spectroscopy fluorescence resonance energy transfer.	SREBF1 SREBF2	6.77e-06	2	91	2	15798184
Pubmed	SREBP transcription factors: master regulators of lipid homeostasis.	SREBF1 SREBF2	6.77e-06	2	91	2	15589694
Pubmed	Transcriptional regulation of phagocytosis-induced membrane biogenesis by sterol regulatory element binding proteins.	SREBF1 SREBF2	6.77e-06	2	91	2	16141315
Pubmed	Senolytics prevent caveolar CaV 3.2-RyR axis malfunction in old vascular smooth muscle.	CACNA1H RYR1	6.77e-06	2	91	2	37837625
Pubmed	Whole Exome Sequencing of Hemiplegic Migraine Patients Shows an Increased Burden of Missense Variants in CACNA1H and CACNA1I Genes.	CACNA1I CACNA1H	6.77e-06	2	91	2	36786913
Pubmed	Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes.	SREBF1 SREBF2	6.77e-06	2	91	2	10585467
Pubmed	Determinants of variable response to simvastatin treatment: the role of common variants of SCAP, SREBF-1a and SREBF-2 genes.	SREBF1 SREBF2	6.77e-06	2	91	2	16158080
Pubmed	Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13.	SREBF1 SREBF2	6.77e-06	2	91	2	7759101
Pubmed	Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver.	SREBF1 SREBF2	6.77e-06	2	91	2	18413311
Pubmed	Sterol-regulatory-element binding protein inhibits upstream stimulatory factor-stimulated hepatic lipase gene expression.	LIPC SREBF2	6.77e-06	2	91	2	15721010
Pubmed	Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence.	SREBF1 SREBF2	6.77e-06	2	91	2	15026365
Pubmed	Role for sterol regulatory element-binding protein in activation of endothelial cells by phospholipid oxidation products.	SREBF1 SREBF2	6.77e-06	2	91	2	15388640
Pubmed	The potential role of sterol regulatory element binding protein transcription factors in renal injury.	SREBF1 SREBF2	6.77e-06	2	91	2	17198935
Pubmed	Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples.	SREBF1 SREBF2	6.77e-06	2	91	2	18936756
Pubmed	Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer.	SREBF1 SREBF2	6.77e-06	2	91	2	29449559
Pubmed	SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene.	SREBF1 SREBF2	6.77e-06	2	91	2	8402897
Pubmed	SREBF1c and SREBF2 gene polymorphisms are associated with acute coronary syndrome and blood lipid levels in Mexican population.	SREBF1 SREBF2	6.77e-06	2	91	2	31490983
Pubmed	Expanding roles for SREBP in metabolism.	SREBF1 SREBF2	6.77e-06	2	91	2	23000402
Pubmed	CREating a SCAP-less liver keeps SREBPs pinned in the ER membrane and prevents increased lipid synthesis in response to low cholesterol and high insulin.	SREBF1 SREBF2	6.77e-06	2	91	2	11485982
Pubmed	SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.	SREBF1 SREBF2	6.77e-06	2	91	2	7903453
Pubmed	Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2.	SREBF1 SREBF2	6.77e-06	2	91	2	17921436
Pubmed	Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.	SREBF1 SREBF2	6.77e-06	2	91	2	9329978
Pubmed	Regulation of the ADMA-DDAH system in endothelial cells: a novel mechanism for the sterol response element binding proteins, SREBP1c and -2.	SREBF1 SREBF2	6.77e-06	2	91	2	19915177
Pubmed	De novo SCN8A and inherited rare CACNA1H variants associated with severe developmental and epileptic encephalopathy.	SCN8A CACNA1H	6.77e-06	2	91	2	34399820
Pubmed	Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2).	SREBF1 SREBF2	6.77e-06	2	91	2	9070916
Pubmed	Diet-induced obesity in C57BL/6J mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent pathway.	SREBF1 SREBF2	6.77e-06	2	91	2	16046411
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	HYOU1 NUP85 UBR4 USP24 CKAP5 DIAPH1 WDR18 IPO4 PLS3 SYMPK	6.81e-06	638	91	10	33239621
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	RAB18 VRK2 FAM111A NUP85 CCDC87 WDR18 PARP14 PHF10	1.26e-05	410	91	8	26949251
Pubmed	An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.	THRA SREBF1 SREBF2	1.63e-05	19	91	3	16799563
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	WAPL NUP85 KBTBD6 ANAPC2 LTN1 CKAP5 DIAPH1 IPO4 SYMPK	1.66e-05	560	91	9	35241646
Pubmed	Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status.	SREBF1 SREBF2	2.03e-05	3	91	2	11739104
Pubmed	Ethanol inhibition of a T-type Ca²+ channel through activity of protein kinase C.	CACNA1I CACNA1H	2.03e-05	3	91	2	23488970
Pubmed	Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.	SREBF1 SREBF2	2.03e-05	3	91	2	12032166
Pubmed	A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies.	SREBF1 SREBF2	2.03e-05	3	91	2	11929849
Pubmed	T-type channels: release a brake, engage a gear.	CACNA1I CACNA1H	2.03e-05	3	91	2	26488564
Pubmed	Anti-cancer efficacy of SREBP inhibitor, alone or in combination with docetaxel, in prostate cancer harboring p53 mutations.	SREBF1 SREBF2	2.03e-05	3	91	2	26512780
Pubmed	Growth factor-induced phosphorylation of sterol regulatory element-binding proteins inhibits sumoylation, thereby stimulating the expression of their target genes, low density lipoprotein uptake, and lipid synthesis.	SREBF1 SREBF2	2.03e-05	3	91	2	18403372
Pubmed	Differential interactions of Na+ channel toxins with T-type Ca2+ channels.	CACNA1I CACNA1H	2.03e-05	3	91	2	18591418
Pubmed	Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP.	SREBF1 SREBF2	2.03e-05	3	91	2	26028026
Pubmed	Identification of the t-type calcium channel (Ca(v)3.1d) in developing mouse heart.	CACNA1I CACNA1H	2.03e-05	3	91	2	11230107
Pubmed	Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation.	CACNA1I CACNA1H	2.03e-05	3	91	2	28846697
Pubmed	Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes.	SREBF1 SREBF2	2.03e-05	3	91	2	14512514
Pubmed	Homeostatic plasticity and burst activity are mediated by hyperpolarization-activated cation currents and T-type calcium channels in neuronal cultures.	CACNA1I CACNA1H	2.03e-05	3	91	2	33547341
Pubmed	Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi.	SREBF1 SREBF2	2.03e-05	3	91	2	10619424
Pubmed	Calmodulin regulates Cav3 T-type channels at their gating brake.	CACNA1I CACNA1H	2.03e-05	3	91	2	28972185
Pubmed	A functional interaction between Hippo-YAP signalling and SREBPs mediates hepatic steatosis in diabetic mice.	SREBF1 SREBF2	2.03e-05	3	91	2	30821074
Pubmed	Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability.	CACNA1I CACNA1H	2.03e-05	3	91	2	11927664
Pubmed	The Niemann-Pick C1 gene is downregulated by feedback inhibition of the SREBP pathway in human fibroblasts.	SREBF1 SREBF2	2.03e-05	3	91	2	18272927
Pubmed	A novel functional interaction between the Sp1-like protein KLF13 and SREBP-Sp1 activation complex underlies regulation of low density lipoprotein receptor promoter function.	SREBF1 SREBF2	2.03e-05	3	91	2	16303770
Pubmed	Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein.	SREBF1 SREBF2	2.03e-05	3	91	2	9242699
Pubmed	Human caspase 7 is positively controlled by SREBP-1 and SREBP-2.	SREBF1 SREBF2	2.03e-05	3	91	2	19323650
Pubmed	Activation of sterol regulatory element binding protein and NLRP3 inflammasome in atherosclerotic lesion development in diabetic pigs.	SREBF1 SREBF2	2.03e-05	3	91	2	23825667
Pubmed	Lipid deprivation increases surfactant phosphatidylcholine synthesis via a sterol-sensitive regulatory element within the CTP:phosphocholine cytidylyltransferase promoter.	SREBF1 SREBF2	2.03e-05	3	91	2	11829742
Pubmed	Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice.	CACNA1I CACNA1H	2.03e-05	3	91	2	11897840
Pubmed	Resveratrol increases the expression and activity of the low density lipoprotein receptor in hepatocytes by the proteolytic activation of the sterol regulatory element-binding proteins.	SREBF1 SREBF2	2.03e-05	3	91	2	22153697
Pubmed	Mutant huntingtin interacts with the sterol regulatory element-binding proteins and impairs their nuclear import.	SREBF1 SREBF2	2.03e-05	3	91	2	31875875
Pubmed	Sterol regulatory element-binding proteins are regulators of the NIS gene in thyroid cells.	SREBF1 SREBF2	2.03e-05	3	91	2	23542164
Pubmed	[Genetic predisposition to ischemic heart disease in patients with obstructive sleep apnea syndrome (OSAS)].	SREBF1 SREBF2	2.03e-05	3	91	2	24868893
Pubmed	Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP.	SREBF1 SREBF2	2.03e-05	3	91	2	30718857
Pubmed	Identification and validation of seven new loci showing differential DNA methylation related to serum lipid profile: an epigenome-wide approach. The REGICOR study.	SREBF1 SREBF2	2.03e-05	3	91	2	28173150
Pubmed	Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.	SREBF1 SREBF2	2.03e-05	3	91	2	15085196
Pubmed	Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia.	HLA-E CACNA1I	2.03e-05	3	91	2	22883433
Pubmed	Identification of human ELOVL5 enhancer regions controlled by SREBP.	SREBF1 SREBF2	2.03e-05	3	91	2	26321664
Pubmed	The KBTBD6/7-DRD2 axis regulates pituitary adenoma sensitivity to dopamine agonist treatment.	KBTBD6 KBTBD7	2.03e-05	3	91	2	32572597
Pubmed	Selective role of sterol regulatory element binding protein isoforms in aggregated LDL-induced vascular low density lipoprotein receptor-related protein-1 expression.	SREBF1 SREBF2	2.03e-05	3	91	2	20980003
Pubmed	Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity.	SREBF1 SREBF2	2.03e-05	3	91	2	23563690
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	PHKA1 WAPL HYOU1 UBR4 LTN1 USP24	2.07e-05	212	91	6	33853758
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	URB1 SETX UBR4 SCN8A CCDC87 DNAH2 CKAP5 PARP14 RYR1 SYMPK	2.33e-05	736	91	10	29676528
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	TTC7B STARD9 NYNRIN UBR4 DNAH2 DNAH11	3.51e-05	233	91	6	37704626
Pubmed	Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.	IFT140 EVC2 DNAH11	3.82e-05	25	91	3	27340223
Pubmed	MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis.	SREBF1 SREBF2	4.05e-05	4	91	2	20466882
Pubmed	Sterol response element binding protein and thyroid transcription factor-1 (Nkx2.1) regulate Abca3 gene expression.	SREBF1 SREBF2	4.05e-05	4	91	2	17890326
Pubmed	Peroxisome deficiency causes a complex phenotype because of hepatic SREBP/Insig dysregulation associated with endoplasmic reticulum stress.	SREBF1 SREBF2	4.05e-05	4	91	2	19110480
Pubmed	Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade.	SREBF1 SREBF2	4.05e-05	4	91	2	10627507
Pubmed	Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice.	SREBF1 SREBF2	4.05e-05	4	91	2	28244871
Pubmed	Pharmacogenetics of antiepileptic drug efficacy in childhood absence epilepsy.	CACNA1I CACNA1H	4.05e-05	4	91	2	28165634
Pubmed	Srebp-controlled glucose metabolism is essential for NK cell functional responses.	SREBF1 SREBF2	4.05e-05	4	91	2	28920951
Pubmed	Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice.	SREBF1 SREBF2	4.05e-05	4	91	2	16890542
Pubmed	Interaction between sterol regulatory element-binding proteins and liver receptor homolog-1 reciprocally suppresses their transcriptional activities.	SREBF1 SREBF2	4.05e-05	4	91	2	17283069
Pubmed	SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein.	SREBF1 SREBF2	4.05e-05	4	91	2	8918891
Pubmed	mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.	SREBF1 SREBF2	4.05e-05	4	91	2	21816276
Interaction	C19orf38 interactions	SETX NUP85 LTN1 USP24 CKAP5 PRMT9	2.52e-06	86	91	6	int:C19orf38
Interaction	COMTD1 interactions	PHKA1 WAPL DYM SETX NUP85 CKAP5 PRMT9 IPO4	3.44e-06	200	91	8	int:COMTD1
Interaction	NPTN interactions	SETX NUP85 ANAPC2 LTN1 USP24 FBXL12 IPO4 SYMPK	3.75e-05	278	91	8	int:NPTN
Interaction	GPR17 interactions	URB1 RAB18 WAPL DYM SETX LTN1 USP24 PRMT9	4.25e-05	283	91	8	int:GPR17
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C15orf62 GIMAP4 LIPC FAM111A ITGB7 RYR1	1.61e-06	175	91	6	738b3d476ac494e2e79b70b3b83bc1b7ae8396bd
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-CD45____B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C15orf62 GIMAP4 LIPC FAM111A ITGB7 RYR1	1.78e-06	178	91	6	5a4f97d19265577cfdb3e53f9dc3a9a02cfcffa9
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	GALK2 HYOU1 PIAS3 DIAPH1 SIRT3 SYMPK	1.90e-06	180	91	6	81d60f0fa9e3b5bfcec85139a0a49e9130145f0e
Disease	hypothyroidism (implicated_via_orthology)	PHKA1 LIPC ARSA THRA	5.67e-08	13	90	4	DOID:1459 (implicated_via_orthology)
Disease	lipid storage disease (biomarker_via_orthology)	SREBF1 SREBF2	9.20e-06	2	90	2	DOID:9455 (biomarker_via_orthology)
Disease	alcohol use disorder (implicated_via_orthology)	SREBF1 SREBF2 KDM5D PHF10 RYR1	3.34e-04	195	90	5	DOID:1574 (implicated_via_orthology)
Disease	mean reticulocyte volume	TTC7A MCFD2 SPHK1 NYNRIN RTTN DNAH2 CPNE1 IDUA SIRT3	7.48e-04	799	90	9	EFO_0010701
Disease	Insulin Sensitivity	LIPC SREBF1 SREBF2	8.28e-04	60	90	3	C0920563
Disease	Insulin Resistance	LIPC SREBF1 SREBF2	8.28e-04	60	90	3	C0021655
Disease	level of Sphingomyelin (d34:1) in blood serum	LIPC USP24	1.36e-03	18	90	2	OBA_2045175
Disease	Hypercholesterolemia, Familial	LIPC SREBF2	1.36e-03	18	90	2	C0020445
Disease	Disproportionate short stature	IFT140 EVC2 DYM	1.71e-03	77	90	3	C0878659
Disease	kidney disease (biomarker_via_orthology)	SREBF1 SREBF2	1.86e-03	21	90	2	DOID:557 (biomarker_via_orthology)
Disease	type 2 diabetes mellitus (is_implicated_in)	LIPC SPHK1 SREBF1 SREBF2	1.89e-03	171	90	4	DOID:9352 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LELTAEDLTQMGITL	EPHA1	946	P21709
VLMFGLLVESQTLLE	PRMT9	696	Q6P2P2
LGLVTMDVELADRTL	ANAPC2	641	Q9UJX6
VSLLGLIDEVMVLLG	CYP2W1	196	Q8TAV3
EGLDLISMLTDDATI	DNAH11	3451	Q96DT5
LHLTIGMLVLLSEEE	ASCC1	206	Q8N9N2
SSIILLSEEDLQMLV	DFFA	136	O00273
LNLMESSLVSLLEEI	CCDC87	776	Q9NVE4
IKTMLETEEGILLLV	DIAPH1	231	O60610
ELDLLSEILDSLSMG	DENND1C	556	Q8IV53
GLASVRMELILLLQE	DMXL1	2146	Q9Y485
SLVLLLDAMDDLDSV	NWD1	431	Q149M9
MDEDVLTTLKILIIG	RAB18	1	Q9NP72
TEGIVDLTEMILLLL	GSTA5	96	Q7RTV2
AALMSLLSIQEDLLE	LTN1	1436	O94822
LLVGFLEDVMTLLSL	RELCH	926	Q9P260
MVDGTLLLLLSEALA	HLA-E	1	P13747
MSTELLLEDGLLLSQ	KIAA0100	331	Q14667
LMSEDELINIIDGVL	MCFD2	111	Q8NI22
LIFDMDGLLLDTERL	PUDP	11	Q08623
LLVEAILVLTMLADI	PHKA1	1126	P46020
TLTELRVLLEQMGSL	KDM5D	836	Q9BY66
LGLAAKLMELLEEIS	NAA20	86	P61599
LAALLRDGETLEELM	PLS3	251	P13797
LALMIDILEEFSVLS	KIAA1586	526	Q9HCI6
ESLLKIMLGDEAALL	NUP85	281	Q9BW27
LLTLESAIDTLAETM	FRYL	1871	O94915
GISLEEMLLVTEDAL	GALK2	276	Q01415
SDIAVEMLFILDIIL	KCNH4	266	Q9UQ05
IQDLLLEELSASEML	EVC2	991	Q86UK5
SFLITLDVDIGELIM	LIPC	401	P11150
LMTAIGDLGLLEETL	ARSA	261	P15289
MGSIREETLADLTLA	KBTBD7	206	Q8WVZ9
LLEIDNSELLLMLES	PABPC1L	571	Q4VXU2
LLELEALSMAVESTG	MVP	706	Q14764
VFELTEMEVLSLELI	LRRC8B	436	Q6P9F7
MVLVLLLVLSRGESE	ITGB7	6	P26010
MGVAQILLEELDLSS	RIMS1	1636	Q86UR5
TDIMLILLVENISGL	PARP14	161	Q460N5
LGLTALRSDEVIDLM	PHF10	136	Q8WUB8
LIDMYVEGTLDLLEL	GSTA4	91	O15217
LITLMLDSRIEDLEE	CKAP5	1646	Q14008
LLALSDTLAVMSVDL	HYOU1	26	Q9Y4L1
MALIILLILTEDDGF	DYM	396	Q7RTS9
IIEFGSTMESILLDI	FAM111A	571	Q96PZ2
LAIVLLSVMGITLEE	CACNA1I	1556	Q9P0X4
VLTAMGLLALLDEEQ	IDUA	386	P35475
LLPEELELLSESMVE	ITIH6	1001	Q6UXX5
LAIVLLSLMGITLEE	CACNA1H	1686	O95180
GLLDTLIEMNTILED	DNAH2	1501	Q9P225
ERIAELLGMDLATLE	RYR1	4736	P21817
ADIALIEGSLLVMAV	IFT140	281	Q96RY7
MESAGLEQLLRELLL	IPO4	1	Q8TEX9
MLLLLTDGAVTDVEA	CPNE1	416	Q99829
MGSIREETLADLTLA	KBTBD6	206	Q86V97
MDVFLLQLVGELLEL	NYNRIN	1786	Q9P2P1
LELLTEDMTLIGEAI	RTTN	406	Q86VV8
LDLLDSFTLVELMLE	TMEM121B	401	Q9BXQ6
VESKDGILELIMTAL	GIMAP4	301	Q9NUV9
LEATGILDEATLALM	MMP17	91	Q9ULZ9
LLEQGSMILALSDTE	CCDC51	361	Q96ER9
MATLVELPDSVLLEI	FBXL12	1	Q9NXK8
LLSSAIITEEMLQDL	EPPK1	2186	P58107
LSVEDILNLLGMESA	SCG2	431	P13521
METLGALLVLEFLLL	SMIM24	1	O75264
TILEEQAMDSLLLGS	SETX	246	Q7Z333
MADLLLILGTSLEVE	SIRT3	311	Q9NTG7
IGTFTEKDIELILLM	NOM1	491	Q5C9Z4
SILLMETEVEDLSLI	NOM1	786	Q5C9Z4
GELLLSVLFDVSIMA	WDR18	206	Q9BV38
LMALEDDVLSTGVVL	STARD9	481	Q9P2P6
EEIGFTLSEDMILLT	URB1	766	O60287
LDAALLTDIEDMLQL	SREBF1	21	P36956
MLDLDIQELASLTTG	AAGAB	241	Q6PD74
VDLGISLLEEVLQML	C15orf62	151	A8K5M9
ESLIIDGLFMEILSS	PIAS3	376	Q9Y6X2
ISLDSMILEEQLLES	UHRF1BP1L	1116	A0JNW5
ILLSGSLDDIIEVEM	SMC1B	941	Q8NDV3
GEDEVDHLILLALMT	PTGIR	231	P43119
ETMETLTELGDELTL	SREBF2	11	Q12772
LDLMIRLLELEQDAS	WAPL	741	Q7Z5K2
SLSLMELSLADVEGL	SCN8A	826	Q9UQD0
VSAMAGDIILLLDSD	SYMPK	161	Q92797
LLDLDIPMSVGIIDT	UBP1	146	Q9NZI7
LLVGQTMPTLLDEDL	USP24	1246	Q9UPU5
RELTGSLLALIEMVV	USP24	2406	Q9UPU5
EEALLLLLISESMAN	TTC7B	326	Q86TV6
NIEEALLLLLISESM	TTC7A	341	Q9ULT0
LLAEAEISFTLMLTE	SPHK1	41	Q9NYA1
LDDTEVALLQAVLLM	THRA	311	P10827
LVALLEDDSGMELLV	UBR4	4396	Q5T4S7
STVLQLGIRMLDVLE	VRK2	141	Q86Y07
VSLVLLSLIMVDIIE	TMEM236	131	Q5W0B7
LMDEGAVLTLVADLS	L1TD1	236	Q5T7N2
TDLEDLTLGEIEVMI	NAT9	96	Q9BTE0