Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	positive regulation of termination of DNA-templated transcription	SETX WNK1	9.48e-06	2	64	2	GO:0060566
GeneOntologyBiologicalProcess	positive regulation of termination of RNA polymerase II transcription	SETX WNK1	9.48e-06	2	64	2	GO:1904595
GeneOntologyBiologicalProcess	regulation of termination of RNA polymerase II transcription	SETX WNK1	5.66e-05	4	64	2	GO:1904594
Domain	GOLGA6L	GOLGA6L10 GOLGA6L19	1.83e-04	6	66	2	IPR026737
Domain	PLAC	ADAMTS16 ADAMTS17	1.09e-03	14	66	2	PF08686
Domain	GOLGA2L5	GOLGA6L10 GOLGA6L19	1.81e-03	18	66	2	PF15070
Domain	Golgin_A	GOLGA6L10 GOLGA6L19	1.81e-03	18	66	2	IPR024858
Domain	PLAC	ADAMTS16 ADAMTS17	2.02e-03	19	66	2	PS50900
Domain	PLAC	ADAMTS16 ADAMTS17	2.02e-03	19	66	2	IPR010909
Domain	TPR_REGION	RGPD2 RAPSN DNAH2 CFAP46	2.77e-03	165	66	4	PS50293
Domain	TPR	RGPD2 RAPSN DNAH2 CFAP46	2.77e-03	165	66	4	PS50005
Domain	ADAM_spacer1	ADAMTS16 ADAMTS17	2.97e-03	23	66	2	IPR010294
Domain	ADAM_spacer1	ADAMTS16 ADAMTS17	2.97e-03	23	66	2	PF05986
Domain	Peptidase_M12B_ADAM-TS	ADAMTS16 ADAMTS17	3.23e-03	24	66	2	IPR013273
Domain	EGF_CA	HMCN2 LTBP2 CUBN	3.50e-03	86	66	3	PF07645
Domain	EGF_Ca-bd_CS	HMCN2 LTBP2 CUBN	4.90e-03	97	66	3	IPR018097
Domain	EGF_CA	HMCN2 LTBP2 CUBN	5.19e-03	99	66	3	PS01187
Domain	ASX_HYDROXYL	HMCN2 LTBP2 CUBN	5.34e-03	100	66	3	PS00010
Domain	-	RGPD2 RAPSN NAPG CFAP46	6.18e-03	207	66	4	1.25.40.10
Domain	EGF-type_Asp/Asn_hydroxyl_site	HMCN2 LTBP2 CUBN	6.27e-03	106	66	3	IPR000152
Domain	Cadherin_tail	PCDHA11 PCDHA5	7.56e-03	37	66	2	PF15974
Domain	Cadherin_CBD	PCDHA11 PCDHA5	7.56e-03	37	66	2	IPR031904
Domain	Peptidase_M12B_N	ADAMTS16 ADAMTS17	8.38e-03	39	66	2	IPR002870
Domain	Pep_M12B_propep	ADAMTS16 ADAMTS17	8.38e-03	39	66	2	PF01562
Domain	DISINTEGRIN_1	ADAMTS16 ADAMTS17	8.80e-03	40	66	2	PS00427
Domain	Reprolysin	ADAMTS16 ADAMTS17	8.80e-03	40	66	2	PF01421
Domain	ADAM_MEPRO	ADAMTS16 ADAMTS17	8.80e-03	40	66	2	PS50215
Domain	DISINTEGRIN_2	ADAMTS16 ADAMTS17	8.80e-03	40	66	2	PS50214
Domain	Peptidase_M12B	ADAMTS16 ADAMTS17	8.80e-03	40	66	2	IPR001590
Domain	EGF_CA	HMCN2 LTBP2 CUBN	9.23e-03	122	66	3	SM00179
Domain	CYSTEINE_SWITCH	ADAMTS16 ADAMTS17	9.23e-03	41	66	2	PS00546
Domain	Disintegrin_dom	ADAMTS16 ADAMTS17	9.23e-03	41	66	2	IPR001762
Domain	TPR-like_helical_dom	RGPD2 RAPSN NAPG CFAP46	9.30e-03	233	66	4	IPR011990
Domain	EGF-like_Ca-bd_dom	HMCN2 LTBP2 CUBN	9.64e-03	124	66	3	IPR001881
Domain	Pept_M10_metallopeptidase	ADAMTS16 ADAMTS17	1.01e-02	43	66	2	IPR001818
Domain	Kinesin-like_fam	KIF26A KIF17	1.01e-02	43	66	2	IPR027640
Pubmed	PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.	PTPN1 RNF213	3.88e-06	2	69	2	27323329
Pubmed	New insights into TNFα/PTP1B and PPARγ pathway through RNF213- a link between inflammation, obesity, insulin resistance, and Moyamoya disease.	PTPN1 RNF213	1.16e-05	3	69	2	33333224
Pubmed	Weill-Marchesani Syndrome	ADAMTS17 LTBP2	2.32e-05	4	69	2	20301293
Pubmed	PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2.	PTPN1 STAM2	3.86e-05	5	69	2	20504764
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	ASB16 PCDHA11 PCDHA5 LTBP2 GRIP2 SELENON	4.97e-05	329	69	6	17474147
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KANSL3 TLNRD1 KIF26A PCNX4 ZZEF1 WNK1 FBXO46 TOP3B EML3 RGS16	6.25e-05	1105	69	10	35748872
Pubmed	Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.	ADAMTS16 ADAMTS17	8.09e-05	7	69	2	11867212
Pubmed	Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.	ARPP21 FARP1 CUBN	8.71e-05	43	69	3	21116278
Pubmed	Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia.	ADAMTS16 ZZEF1	1.08e-04	8	69	2	24039173
Pubmed	Molecular mechanisms governing Pcdh-gamma gene expression: evidence for a multiple promoter and cis-alternative splicing model.	PCDHA11 PCDHA5	1.38e-04	9	69	2	12154121
Pubmed	Implication of geranylgeranyltransferase I in synapse formation.	RAPSN FARP1	1.73e-04	10	69	2	14622576
Pubmed	An intrinsic distinction in neuromuscular junction assembly and maintenance in different skeletal muscles.	RAPSN ISL1	2.11e-04	11	69	2	11988168
Pubmed	Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.	PCDHA11 PCDHA5	2.11e-04	11	69	2	9655502
Pubmed	Proteins of the CNR family are multiple receptors for Reelin.	PCDHA11 PCDHA5	2.53e-04	12	69	2	10612399
Pubmed	Global landscape of HIV-human protein complexes.	ERP44 MARS1 RNF213 MSH2 EML3 SPAG5	2.97e-04	457	69	6	22190034
Pubmed	HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity.	SMURF1 ISL1	3.48e-04	14	69	2	26147758
Pubmed	Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons.	PCDHA11 PCDHA5	4.01e-04	15	69	2	15640798
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTS16 ADAMTS17 CUBN	4.56e-04	75	69	3	20637190
Pubmed	Myocardial-specific R-spondin3 drives proliferation of the coronary stems primarily through the Leucine Rich Repeat G Protein coupled receptor LGR4.	RNF213 ISL1	4.57e-04	16	69	2	29859889
Pubmed	Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.	PCDHA11 PCDHA5	5.18e-04	17	69	2	29911975
Pubmed	CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity.	PCDHA11 PCDHA5	5.81e-04	18	69	2	15570159
Pubmed	Genomic organization of the family of CNR cadherin genes in mice and humans.	PCDHA11 PCDHA5	5.81e-04	18	69	2	10662547
Pubmed	Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal.	PKD2L1 ISL1	6.49e-04	19	69	2	31461644
Pubmed	Tbx1 coordinates addition of posterior second heart field progenitor cells to the arterial and venous poles of the heart.	LTBP2 ISL1	7.20e-04	20	69	2	25190705
Pubmed	Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.	PCDHA11 PCDHA5	1.04e-03	24	69	2	24698270
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PTPN1 STAM2 FARP1 RNF213 MSH2 CRYBG3 TOP3B CPSF3	1.10e-03	1049	69	8	27880917
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	KANSL3 STAM2 SETX ANKRD26 CRYBG3 WNK1	1.11e-03	588	69	6	38580884
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	SETX ERP44 MARS1 FARP1 SMURF1 CUBN WNK1 SPAG5	1.35e-03	1084	69	8	11544199
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHA11 PCDHA5	1.42e-03	28	69	2	15347688
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	RGPD2 ERP44 CRYBG3 PCCB SPAG5	1.46e-03	418	69	5	34709266
Pubmed	Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo.	ERP44 NDUFAF7 FARP1 TRIM71 CUBN	1.69e-03	432	69	5	7671812
Pubmed	The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling.	TRIM71 ISL1	1.74e-03	31	69	2	22508726
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	SETX MARS1 RNF213 PCCB	1.85e-03	262	69	4	36880596
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS16 ADAMTS17	1.10e-03	19	47	2	50
Coexpression	GSE1460_CD4_THYMOCYTE_VS_THYMIC_STROMAL_CELL_UP	GVINP1 CD38 MSH2 KIF17 FBXO46 CFAP46	1.21e-05	199	67	6	M3478
CoexpressionAtlas	FacebaseRNAseq_e9.5_Mandibular Arch_top-relative-expression-ranked_500_k-means-cluster#5	PTPN1 GPR50 ISL1 SPAG5	2.15e-06	29	68	4	Facebase_RNAseq_e9.5_Mandibular Arch_500_K5
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS16 ADAMTS17 TRIM71 LTBP2 TSC22D2 WNK1	1.83e-07	160	69	6	2d391ba6f7adb55dfa89feecc10cc9ce97e5fe74
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS16 ADAMTS17 TRIM71 LTBP2 TSC22D2 WNK1	1.83e-07	160	69	6	8bcdbcfdf1e0ace6053e8de82762f6e2f86bba7a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS16 ADAMTS17 TRIM71 TSC22D2 WNK1	7.31e-06	173	69	5	4bc6d93716f093b460c8b047199db8cab5fea720
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS16 ADAMTS17 TRIM71 TSC22D2 WNK1	9.10e-06	181	69	5	e0abf2707d9e0aa942c657eef7d2cbcd02f060dd
Disease	Weill-Marchesani syndrome	ADAMTS17 LTBP2	2.77e-05	4	64	2	cv:C0265313
Disease	Weill-Marchesani syndrome (is_implicated_in)	ADAMTS17 LTBP2	2.77e-05	4	64	2	DOID:0050475 (is_implicated_in)
Disease	1-(1-enyl-stearoyl)-2-arachidonoyl-GPC (P-18:0/20:4) measurement	RAPSN PKD2L1	6.91e-05	6	64	2	EFO_0800394
Disease	functional impairment measurement	ADAMTS16 ZZEF1	9.66e-05	7	64	2	EFO_0005412
Disease	fatty acid desaturase enzyme activity measurement	RAPSN PKD2L1	1.29e-04	8	64	2	EFO_0009791
Disease	1-(1-enyl-palmitoyl)-2-palmitoleoyl-GPC (P-16:0/16:1) measurement	RAPSN PKD2L1	2.06e-04	10	64	2	EFO_0800464
Disease	low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	FCSK RAPSN PKD2L1 PCCB	3.47e-04	153	64	4	EFO_0004611, EFO_0020946
Disease	level of Phosphatidylcholine (16:1_18:1) in blood serum	RAPSN PKD2L1	3.56e-04	13	64	2	OBA_2045082
Disease	heart failure, diabetes mellitus, stroke, atrial fibrillation, mortality, coronary artery disease, cancer	DNAH2 ANKRD26	8.58e-04	20	64	2	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004352, MONDO_0004992
Disease	saturated fatty acids to total fatty acids percentage	RAPSN PKD2L1	9.47e-04	21	64	2	EFO_0022305
Disease	level of Phosphatidylcholine (16:1_18:2) in blood serum	RAPSN PKD2L1	9.47e-04	21	64	2	OBA_2045083
Disease	Vitiligo	PTPN1 RAPSN MSH2	1.39e-03	101	64	3	EFO_0004208
Disease	ceramide measurement	SPTLC3 RAPSN PKD2L1 KIF17	1.71e-03	235	64	4	EFO_0010222
Disease	suicidal ideation	LTBP2 CFAP46	1.81e-03	29	64	2	EFO_0004320
Disease	1,5 anhydroglucitol measurement	PCDHA11 PCDHA5	1.81e-03	29	64	2	EFO_0008009

Protein segments in the cluster

Peptide	Gene	Start	Entry
CSEASAEHIEARRRA	CRYBG3	1171	Q68DQ2
EEREARFCNTVHDIV	CPSF3	216	Q9UKF6
VATFHDCEDAARELQ	DPM3	61	Q9P2X0
VTCFSDVIRFDVNTH	GVINP1	1651	Q7Z2Y8
NVDIRAFIESCSHRS	BNC1	201	Q01954
ALHEACARAQFDCVR	ASB16	146	Q96NS5
DAAEVEHCLTRRFRD	ANKRD18B	46	A2A2Z9
EAAARHEEAVGQVCV	CFAP46	1516	Q8IYW2
QEAQDRHTEAVRCAE	ANKRD26	1271	Q9UPS8
VRERIFAHDSVCSQE	ARPP21	291	Q9UBL0
PRDSVDFRAAQCAEH	ADAMTS16	641	Q8TE57
DFRAAQCAEHNSRRF	ADAMTS16	646	Q8TE57
VDAAVFVTRTDFCVH	ADAMTS17	336	Q8TE56
DAAEVEHCLTRRFRD	ANKRD19P	46	Q9H560
TVSRRFAEAACDVVH	CD38	191	P28907
LFDHHVQRAVCDTRA	RBM48	11	Q5RL73
RAHVVRFHECVEETE	RAPSN	346	Q13702
ACEQAEADAVHLARE	RAB36	246	O95755
CHIFTVSARDADAQE	PCDHA11	471	Q9Y5I1
QDIRHEASDFPCRVA	PTPN1	21	P18031
CDASRRIVVADKDNH	TRIM71	661	Q2Q1W2
EESHSRNDCRAVIIF	MAS1	176	P04201
TGEQRIHAREDACIF	FAM27B	46	Q5VT28
CVAVSEAGEARRHFQ	HMCN2	3481	Q8NDA2
GSREERREAFAAACH	DOP1B	741	Q9Y3R5
FSCLVNGEEREQTHR	MAPK8IP2	596	Q13387
HARDQAREQDRAHAC	GPR50	341	Q13585
AREQDRAHACPAVEE	GPR50	346	Q13585
CHTAEARRVDEVFED	PCNX4	691	Q63HM2
RVAEAVAHFEAQRDS	FBXO46	226	Q6PJ61
RDADHFRCSTFAELQ	KIF26A	831	Q9ULI4
AEEAACHSFRAAENR	GOLGA6L10	501	A6NI86
EAACHSFRAAENREL	GOLGA6L19	531	H0YKK7
CHIFTVSARDADAQE	PCDHA5	471	Q9Y5H7
VAHRAFENDVDALCN	PCCB	256	P05166
HFELERSTTCARDFV	CUBN	1666	O60494
HSLVRQTEECAEGFR	FCSK	961	Q8N0W3
SHADFRDCRAALAEI	FARP1	706	Q9Y4F1
FVEACRAREAAFDAE	EID2	181	Q8N6I1
CNVARIEAEREAGVH	LTBP2	1636	Q14767
VFARVDCDQHSDIAQ	ERP44	86	Q9BS26
RVFERVANILHDDCA	ERP44	176	Q9BS26
NECERHVIFARTDAD	KANSL3	101	Q9P2N6
CRSHNERVVAVADDF	EML3	801	Q32P44
VNHVRTRDFDCCLAV	GRIP2	991	Q9C0E4
HECFRVFSDRLVDAA	DNAH2	2646	Q9P225
ASRHACVEVQDEIAF	MSH2	636	P43246
RAFEHVFESVQCAEN	KIF17	116	Q9P2E2
AEIVLEAFCAHASQR	SPAG5	581	Q96R06
RCLVENAGDVAFVRH	MELTF	561	P08582
CIRHSSTFDQTAERD	TSC22D2	201	O75157
AFIQHDETRDHVEVC	NDUFAF7	261	Q7L592
KDAVARCHEAERNIA	RGPD2	181	P0DJD1
EEELCHRREARAFSE	SETX	2626	Q7Z333
AEARARFCVSAAHTR	SPTLC3	496	Q9NUV7
GLFCRADHDVVERAS	ISL1	126	P61371
AGHCRIEVSREEIFE	SMURF1	396	Q9HCE7
ELRTHRAFCASNTED	ABHD1	166	Q96SE0
DIDVDRVACFHDAVQ	RNF213	1456	Q63HN8
HCFENAHRVRVSADT	TOP3B	756	O95985
DACLREAVAHENNRA	NAPG	56	Q99747
HRNDYVAAERCVRES	NAPG	206	Q99747
RQRLEHFAANCEEAI	PLEKHG4B	346	Q96PX9
VRVCARHAEAQAAAR	SELENON	46	Q9NZV5
DHRERLRNSACAVSE	TLNRD1	321	Q9H1K6
HLEVCSRDFATEVRA	STAM2	81	O75886
ASRAHQIFEEFICSE	RGS16	111	O15492
RNDSCVVHEDFREDI	PKD2L1	206	Q9P0L9
CARAHQAHAVVAEEV	ZNHIT2	361	Q9UHR6
ARAEAEQSVTCAHCR	ZZEF1	706	O43149
EHRFFRRSVICDSNA	WNK1	76	Q9H4A3
QDTVEQLRCEHCARF	MARS1	381	P56192
EVSHQRCQEREFGLE	ZNF175	91	Q9Y473