Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionFc-gamma receptor I complex binding

FLNA IGHG3 IGHG4

4.60e-0671033GO:0034988
GeneOntologyMolecularFunctionprotein-containing complex destabilizing activity

NSF KATNA1 CLPB

5.80e-05151033GO:0140776
GeneOntologyMolecularFunctionadenosine-phosphate deaminase activity

AMPD1 AMPD3

7.88e-0531032GO:0047623
GeneOntologyMolecularFunctionAMP deaminase activity

AMPD1 AMPD3

7.88e-0531032GO:0003876
GeneOntologyMolecularFunctionimmunoglobulin receptor binding

FLNA IGHG3 IGHG4

1.66e-04211033GO:0034987
GeneOntologyMolecularFunctionATP-dependent protein disaggregase activity

NSF CLPB

3.90e-0461032GO:0140545
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

ZGRF1 SMARCAD1 CHD6 DSCC1 TOP2B

5.12e-041271035GO:0008094
GeneOntologyBiologicalProcessneuron migration

FLNA VAX1 NEXMIF DAB1 KATNA1 NRP1 KIRREL3 TOP2B

1.70e-052181068GO:0001764
GeneOntologyBiologicalProcessnegative regulation of neuron projection development

FLNA DAB1 KATNA1 ACTR3 NRP1 INPP5J DYNC1I2

2.70e-051691067GO:0010977
GeneOntologyBiologicalProcesssister chromatid segregation

FLNA SMC2 PBRM1 NDC80 ANAPC5 GEN1 TOP2B ANAPC4

5.05e-052541068GO:0000819
GeneOntologyBiologicalProcessB cell receptor signaling pathway

TEC BLK CD22 IGHG3 IGHG4

5.43e-05791065GO:0050853
GeneOntologyBiologicalProcessregulation of chromosome segregation

SMC2 PBRM1 NDC80 ANAPC5 GEN1 ANAPC4

8.25e-051391066GO:0051983
GeneOntologyBiologicalProcesschromosome separation

SMARCAD1 SMC2 NDC80 ANAPC5 GEN1

9.10e-05881065GO:0051304
GeneOntologyBiologicalProcessnuclear chromosome segregation

FLNA SMC2 ACTR3 PBRM1 NDC80 ANAPC5 GEN1 TOP2B ANAPC4

9.27e-053561069GO:0098813
GeneOntologyBiologicalProcesssexual reproduction

UNC13B CFAP47 FOXO3 TDRD5 SLC26A3 SMC2 YTHDC1 PKDREJ ACTR3 ADGB USP26 NDC80 KAT8 MEIOSIN C2CD6 ANAPC5 TOP2B ANAPC4

1.19e-04131210618GO:0019953
GeneOntologyBiologicalProcessregulation of mitotic metaphase/anaphase transition

PBRM1 NDC80 ANAPC5 GEN1 ANAPC4

1.31e-04951065GO:0030071
GeneOntologyBiologicalProcessnegative regulation of cellular component organization

FLNA FMR1 ANK3 SPTAN1 DAB1 KATNA1 ACTR3 NRP1 PPARGC1A TBC1D4 NDC80 GEN1 INPP5J DYNC1I2

1.36e-0486410614GO:0051129
GeneOntologyBiologicalProcesschromosome segregation

FLNA SMARCAD1 SMC2 ACTR3 PBRM1 NDC80 ANAPC5 GEN1 TOP2B ANAPC4

1.42e-0446510610GO:0007059
GeneOntologyBiologicalProcessregulation of metaphase/anaphase transition of cell cycle

PBRM1 NDC80 ANAPC5 GEN1 ANAPC4

1.52e-04981065GO:1902099
GeneOntologyBiologicalProcessmetaphase/anaphase transition of mitotic cell cycle

PBRM1 NDC80 ANAPC5 GEN1 ANAPC4

1.67e-041001065GO:0007091
GeneOntologyBiologicalProcesspurine-containing compound salvage

AMPD1 AMPD3 PGM2

1.89e-04221063GO:0043101
GeneOntologyBiologicalProcessmetaphase/anaphase transition of cell cycle

PBRM1 NDC80 ANAPC5 GEN1 ANAPC4

1.91e-041031065GO:0044784
GeneOntologyBiologicalProcessnegative regulation of cell projection organization

FLNA DAB1 KATNA1 ACTR3 NRP1 INPP5J DYNC1I2

2.03e-042331067GO:0031345
GeneOntologyBiologicalProcesspositive regulation of blood-brain barrier permeability

TJP2 OCLN

2.59e-0451062GO:1905605
GeneOntologyBiologicalProcessregulation of sister chromatid segregation

PBRM1 NDC80 ANAPC5 GEN1 ANAPC4

2.71e-041111065GO:0033045
GeneOntologyBiologicalProcessmicrotubule-based process

CFAP47 FLNA FMR1 ANK3 KATNA1 ACTR3 NDC80 NISCH VPS13A C2CD6 OCLN GEN1 ARHGAP21 INPP5J DYNC1I2

3.29e-04105810615GO:0007017
GeneOntologyCellularComponentbasal ectoplasmic specialization

ACTR3 KIAA1210

7.76e-0531072GO:0061832
GeneOntologyCellularComponentanchoring junction

FLNA ANK3 CDHR2 SPTAN1 TEC ACTR3 NRP1 KIAA1210 KIRREL3 FAT1 SH3PXD2A TJP2 ADGRE5 OCLN ARHGAP21

1.33e-0497610715GO:0070161
GeneOntologyCellularComponent9+2 motile cilium

SLC26A3 ADGB USP26 RSPH10B2 VPS13A C2CD6 RSPH10B

2.25e-042381077GO:0097729
GeneOntologyCellularComponentmotile cilium

CFAP47 SLC26A3 ADGB USP26 RSPH10B2 VPS13A C2CD6 RSPH10B

4.84e-043551078GO:0031514
GeneOntologyCellularComponentdendritic shaft

FLNA NSF KIRREL3 INPP5J

5.67e-04741074GO:0043198
MousePhenodecreased memory B cell number

CD22 IGHG3 IGHG4

2.33e-059933MP:0008729
MousePhenoabnormal memory B cell number

CD22 IGHG3 IGHG4

4.53e-0511933MP:0008093
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

PAG1 ACACB ANK3 PLEKHA6 FCHO2 RAB11FIP1 NISCH ITSN2 OCLN ARHGAP21

8.92e-074211091036976175
Pubmed

The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis.

IGHG3 IGHG4 SDC1

1.66e-068109318542049
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

FLNA PAG1 ANK3 SPTAN1 PLEKHA6 SCEL TJP2 N4BP1 OCLN ARHGAP21 TPD52

1.72e-065651091125468996
Pubmed

Global proteomics of Ubqln2-based murine models of ALS.

FLNA RIPK1 SPTAN1 FCHO2 ITSN2 N4BP1 OCLN DYNC1I2

1.79e-06261109833277362
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

FLNA ZC3H13 PLEKHA6 FCHO2 RAB11FIP1 YTHDC1 PBRM1 TBC1D4 OSBPL11 TJP2

4.35e-065031091016964243
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

UNC13B SMARCAD1 USP19 KIRREL3 NISCH ITSN2 DZIP3 CHD6 ARHGAP21

5.73e-06407109912693553
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

FLNA ZC3H13 SPTAN1 SMARCAD1 YTHDC1 USP19 TBC1D4 OSBPL11 TJP2 ANAPC5 TOP2B DYNC1I2

5.92e-067741091215302935
Pubmed

RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1α-mediated mitochondrial oxidative phosphorylation and glycolysis.

RIPK1 PPARGC1A

9.73e-062109224583643
Pubmed

The RNA Binding Proteins YTHDC1 and FMRP Regulate the Nuclear Export of N6-Methyladenosine-Modified Hepatitis B Virus Transcripts and Affect the Viral Life Cycle.

FMR1 YTHDC1

9.73e-062109233883220
Pubmed

The Fragile X Mental Retardation Protein Regulates RIPK1 and Colorectal Cancer Resistance to Necroptosis.

FMR1 RIPK1

9.73e-062109233091622
Pubmed

In vitro protein complex formation with cytoskeleton-anchoring domain of occludin identified by limited proteolysis.

TJP2 OCLN

9.73e-062109214512431
Pubmed

Mutual dependence of Foxo3a and PGC-1alpha in the induction of oxidative stress genes.

FOXO3 PPARGC1A

9.73e-062109219324885
Pubmed

PGC-1α promotes nitric oxide antioxidant defenses and inhibits FOXO signaling against cardiac cachexia in mice.

FOXO3 PPARGC1A

9.73e-062109221435455
Pubmed

[AMPD genes and urate metabolism].

AMPD1 AMPD3

9.73e-062109218409530
Pubmed

N-terminal sequence and distal histidine residues are responsible for pH-regulated cytoplasmic membrane binding of human AMP deaminase isoform E.

AMPD1 AMPD3

9.73e-062109212213808
Pubmed

Inactivation of Foxo3a and subsequent downregulation of PGC-1 alpha mediate nitric oxide-induced endothelial cell migration.

FOXO3 PPARGC1A

9.73e-062109220547753
Pubmed

The cytoplasmic domain of neuropilin-1 regulates focal adhesion turnover.

FLNA NRP1

9.73e-062109224021649
Pubmed

Peroxisome proliferator-activated receptor γ coactivator 1α and FoxO3A mediate chondroprotection by AMP-activated protein kinase.

FOXO3 PPARGC1A

9.73e-062109225047750
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

UNC13B ZNF140 ANK3 ZC3H13 KATNA1 YTHDC1 FAT1 TJP2

1.90e-05361109826167880
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

FMR1 SPTAN1 FCHO2 PBRM1 CLPB DZIP3 CHD6 TOP2B INPP5J

1.96e-05475109931040226
Pubmed

Characterization of the interaction between protein 4.1R and ZO-2. A possible link between the tight junction and the actin cytoskeleton.

SPTAN1 TJP2

2.91e-053109210874042
Pubmed

Leptin administration favors muscle mass accretion by decreasing FoxO3a and increasing PGC-1alpha in ob/ob mice.

FOXO3 PPARGC1A

2.91e-053109219730740
Pubmed

Cloning of human AMP deaminase isoform E cDNAs. Evidence for a third AMPD gene exhibiting alternatively spliced 5'-exons.

AMPD1 AMPD3

2.91e-05310921400401
Pubmed

Platelet AMP deaminase. Purification and kinetic studies.

AMPD1 AMPD3

2.91e-05310927287721
Pubmed

Faster lipid β-oxidation rate by acetyl-CoA carboxylase 2 inhibition alleviates high-glucose-induced insulin resistance via SIRT1/PGC-1α in human podocytes.

ACACB PPARGC1A

2.91e-053109233957017
Pubmed

Novel aspects of tetramer assembly and N-terminal domain structure and function are revealed by recombinant expression of human AMP deaminase isoforms.

AMPD1 AMPD3

2.91e-05310929857047
Pubmed

Evidence for a common mechanism of SIRT1 regulation by allosteric activators.

FOXO3 PPARGC1A

2.91e-053109223471411
Pubmed

The specific fates of tight junction proteins in apoptotic epithelial cells.

TJP2 OCLN

2.91e-053109215054114
Pubmed

FOXO3a-driven miRNA signatures suppresses VEGF-A/NRP1 signaling and breast cancer metastasis.

FOXO3 NRP1

2.91e-053109233262463
Pubmed

HIV-1 gp120 proteins alter tight junction protein expression and brain endothelial cell permeability: implications for the pathogenesis of HIV-associated dementia.

TJP2 OCLN

2.91e-053109215977641
Pubmed

The BAH domain of BAF180 is required for PCNA ubiquitination.

PBRM1 USP1

2.91e-053109226117423
Pubmed

Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection.

BARD1 SMARCAD1

2.91e-053109227239795
Pubmed

A novel dipeptide from potato protein hydrolysate augments the effects of exercise training against high-fat diet-induced damages in senescence-accelerated mouse-prone 8 by boosting pAMPK / SIRT1/ PGC-1α/ pFOXO3 pathway.

FOXO3 PPARGC1A

2.91e-053109232335547
Pubmed

Molecular cloning of AMP deaminase isoform L. Sequence and bacterial expression of human AMPD2 cDNA.

AMPD1 AMPD3

2.91e-05310921429593
Pubmed

Genome-wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population.

UNC13B NSF

2.91e-053109221812969
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

PAG1 RIPK1 AFF3 COL5A3 TEC BLK CLPB SH3PXD2A STK33 ANAPC5 ARHGAP21 ANAPC4

2.94e-059101091236736316
Pubmed

CASK deletion in intestinal epithelia causes mislocalization of LIN7C and the DLG1/Scrib polarity complex without affecting cell polarity.

SPTAN1 OCLN SDC1

3.28e-0520109319726564
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

FMR1 SMARCAD1 SMC2 NRP1 CEMIP PARP4 NISCH OSBPL11 ANAPC5 ARHGAP21

3.94e-056501091038777146
Pubmed

Sequence analysis of cloned cDNA encoding part of an immunoglobulin heavy chain.

IGHG3 IGHG4

5.82e-0541092113776
Pubmed

Highly specific anti-estradiol antibodies: structural characterisation and binding diversity.

IGHG3 IGHG4

5.82e-054109211812141
Pubmed

Multiple amino acid substitutions between murine gamma 2a heavy chain Fc regions of Ig1a and Ig1b allotypic forms.

IGHG3 IGHG4

5.82e-05410926794027
Pubmed

The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton.

TJP2 OCLN

5.82e-05410929792688
Pubmed

Further evidence that BALB/c and C57BL/6 gamma 2a genes originate from two distinct isotypes.

IGHG3 IGHG4

5.82e-05410922510996
Pubmed

Spontaneous deletions in Ig heavy chain genes: flanking sequences influence splice site selection.

IGHG3 IGHG4

5.82e-05410921754385
Pubmed

Sialic acid residues are essential for the anaphylactic activity of murine IgG1 antibodies.

IGHG3 IGHG4

5.82e-054109219050247
Pubmed

An autoimmune disease variant of IgG1 modulates B cell activation and differentiation.

IGHG3 IGHG4

5.82e-054109230287618
Pubmed

Switch transcripts in immunoglobulin class switching.

IGHG3 IGHG4

5.82e-05410927892607
Pubmed

Determination of the primary structure of a mouse G2a immunoglobulin. Identification of the disulfide bridges.

IGHG3 IGHG4

5.82e-05410924565406
Pubmed

Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy.

FOXO3 PPARGC1A

5.82e-054109220404331
Pubmed

IgG1 protects against renal disease in a mouse model of cryoglobulinaemia.

IGHG3 IGHG4

5.82e-054109225363774
Pubmed

Mutational deglycosylation of the Fc portion of immunoglobulin G causes O-sulfation of tyrosine adjacently preceding the originally glycosylated site.

IGHG3 IGHG4

5.82e-054109220621099
Pubmed

Antibody epitopes on the neuraminidase of a recent H3N2 influenza virus (A/Memphis/31/98).

IGHG3 IGHG4

5.82e-054109212414967
Pubmed

Dynamic assembly of tight junction-associated proteins ZO-1, ZO-2, ZO-3 and occludin during mouse tooth development.

TJP2 OCLN

5.82e-054109212507281
Pubmed

Shutdown of class switch recombination by deletion of a switch region control element.

IGHG3 IGHG4

5.82e-05410928438159
Pubmed

Passive anaphylaxis in mice with gamma-G antibodies. V. Competitive effects of different immunoglobulins and inhibition of reactions with antiglobulin sera.

IGHG3 IGHG4

5.82e-05410924098598
Pubmed

Mouse immunoglobulin genes: a bacterial plasmid containing the entire coding sequence for a pre-gamma 2a heavy chain.

IGHG3 IGHG4

5.82e-05410926253932
Pubmed

Immunoglobulin gamma 1 heavy chain gene: structural gene sequences cloned in a bacterial plasmid.

IGHG3 IGHG4

5.82e-05410926769752
Pubmed

Mouse immunoglobulin allotypes: post-duplication divergence of gamma 2a and gamma 2b chain genes.

IGHG3 IGHG4

5.82e-05410926803173
Pubmed

Linkage of the four gamma subclass heavy chain genes.

IGHG3 IGHG4

5.82e-05410926264445
Pubmed

Sequences near the 3' secretion-specific polyadenylation site influence levels of secretion-specific and membrane-specific IgG2b mRNA in myeloma cells.

IGHG3 IGHG4

5.82e-05410922878362
Pubmed

IgG1 deficiency exacerbates experimental autoimmune myasthenia gravis in BALB/c mice.

IGHG3 IGHG4

5.82e-054109225867470
Pubmed

Sequence of the gamma 2b membrane 3' untranslated region: polya site determination and comparison to the gamma 2a membrane 3' untranslated region.

IGHG3 IGHG4

5.82e-05410921542303
Pubmed

Switch of CD4+ T cell differentiation from Th2 to Th1 by treatment with cathepsin B inhibitor in experimental leishmaniasis.

IGHG3 IGHG4

5.82e-05410929725203
Pubmed

Nucleotide sequences of all the gamma gene loci of murine immunoglobulin heavy chains.

IGHG3 IGHG4

5.82e-05410929126488
Pubmed

The IL-4 induced increase in the frequency of resting murine splenic B cells expressing germline Ig heavy chain gamma 1 transcripts correlates with subsequent switching to IgG1.

IGHG3 IGHG4

5.82e-05410928452816
Pubmed

Determination of the primary structure of a mouse IgG2a immunoglobulin:amino-acid sequence of the Fc fragment. Implications for the evolution of immunoglobulin structure and function.

IGHG3 IGHG4

5.82e-05410924831970
Pubmed

Nucleotide sequences of class-switch recombination region of the mouse immunoglobulin gamma 2b-chain gene.

IGHG3 IGHG4

5.82e-05410927439686
Pubmed

On immunoglobulin heavy chain gene switching: two gamma 2b genes are rearranged via switch sequences in MPC-11 cells but only one is expressed.

IGHG3 IGHG4

5.82e-05410926278424
Pubmed

An Asia-specific variant of human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment.

IGHG3 IGHG4

5.82e-054109235133976
Pubmed

Restriction fragment length polymorphism and evolution of the mouse immunoglobulin constant region gamma loci.

IGHG3 IGHG4

5.82e-05410928099342
Pubmed

Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin.

TJP2 OCLN

5.82e-054109210026224
Pubmed

Ubiquitination of IgG1 cytoplasmic tail modulates B-cell signalling and activation.

IGHG3 IGHG4

5.82e-054109232006024
Pubmed

Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries.

ANK3 PBRM1

5.82e-054109221037240
Pubmed

Strong antigenic selection shaping the immunoglobulin heavy chain repertoire of B-1a lymphocytes in lambda 2(315) transgenic mice.

IGHG3 IGHG4

5.82e-054109212209645
Pubmed

Sequence of the cloned gene for the constant region of murine gamma 2b immunoglobulin heavy chain.

IGHG3 IGHG4

5.82e-0541092117549
Pubmed

Cloning immunoglobulin gamma 2b chain gene of mouse: characterization and partial sequence determination.

IGHG3 IGHG4

5.82e-0541092116231
Pubmed

Tight junction protein ZO-2 expression and relative function of ZO-1 and ZO-2 during mouse blastocyst formation.

TJP2 OCLN

5.82e-054109218817772
Pubmed

Highly reduced binding to high and low affinity mouse Fc gamma receptors by L234A/L235A and N297A Fc mutations engineered into mouse IgG2a.

IGHG3 IGHG4

5.82e-054109225451975
Pubmed

Nucleotide sequences of gene segments encoding membrane domains of immunoglobulin gamma chains.

IGHG3 IGHG4

5.82e-05410926283537
Pubmed

Somatic mutation in genes for the variable portion of the immunoglobulin heavy chain.

IGHG3 IGHG4

5.82e-05410926801765
Pubmed

Immunoglobulin diversity: analysis of the germ-line VH gene repertoire of the murine anti-GAT response.

IGHG3 IGHG4

5.82e-05410926306571
Pubmed

The molecular and biochemical characterization of mutant monoclonal antibodies with increased antigen binding.

IGHG3 IGHG4

5.82e-05410921672339
Pubmed

Recognition of a cell-surface oligosaccharide of pathogenic Salmonella by an antibody Fab fragment.

IGHG3 IGHG4

5.82e-05410921713710
Pubmed

Structure of the constant and 3' untranslated regions of the murine Balb/c gamma 2a heavy chain messenger RNA.

IGHG3 IGHG4

5.82e-05410926777755
Pubmed

The roles of gamma 1 heavy chain membrane expression and cytoplasmic tail in IgG1 responses.

IGHG3 IGHG4

5.82e-05410929103199
Pubmed

Gene conversion and polymorphism: generation of mouse immunoglobulin gamma 2a chain alleles by differential gene conversion by gamma 2b chain gene.

IGHG3 IGHG4

5.82e-05410926297797
Pubmed

Evolution of immunoglobulin subclasses. Primary structure of a murine myeloma gamma1 chain.

IGHG3 IGHG4

5.82e-054109298524
Pubmed

Immunoglobulin heavy constant gamma 1 silencing decreases tonicity-responsive enhancer-binding protein expression to alleviate diabetic nephropathy.

IGHG3 IGHG4

5.82e-054109238268239
Pubmed

Gene segments encoding transmembrane carboxyl termini of immunoglobulin gamma chains.

IGHG3 IGHG4

5.82e-05410926799207
Pubmed

Comparison of mouse immunoglobulin gamma 2a and gamma 2b chain genes suggests that exons can be exchanged between genes in a multigenic family.

IGHG3 IGHG4

5.82e-05410926787604
Pubmed

Reelin-Nrp1 Interaction Regulates Neocortical Dendrite Development in a Context-Specific Manner.

DAB1 NRP1

5.82e-054109233009002
Pubmed

CK2-dependent phosphorylation of occludin regulates the interaction with ZO-proteins and tight junction integrity.

TJP2 OCLN

5.82e-054109223758859
Pubmed

Multiple differences between the nucleic acid sequences of the IgG2aa and IgG2ab alleles of the mouse.

IGHG3 IGHG4

5.82e-05410926170065
Pubmed

BRCA1-BARD1 regulates transcription through modulating topoisomerase IIβ.

BARD1 TOP2B

5.82e-054109234610268
Pubmed

Distinction of the memory B cell response to cognate antigen versus bystander inflammatory signals.

IGHG3 IGHG4

5.82e-054109219703988
Pubmed

Resveratrol rescues cadmium-induced mitochondrial injury by enhancing transcriptional regulation of PGC-1α and SOD2 via the Sirt3/FoxO3a pathway in TCMK-1 cells.

FOXO3 PPARGC1A

5.82e-054109228286268
Pubmed

Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch.

IGHG3 IGHG4

5.82e-05410926767246
Pubmed

Determination of the interface of a large protein complex by transferred cross-saturation measurements.

IGHG3 IGHG4

5.82e-054109212051834
Pubmed

The gamma 1 heavy chain gene includes all of the cis-acting elements necessary for expression of properly regulated germ-line transcripts.

IGHG3 IGHG4

5.82e-05410928683112
Pubmed

Genes for immunoglobulin heavy chain and serum prealbumin protein are linked in mouse.

IGHG3 IGHG4

5.82e-0541092807855
InteractionRHOA interactions

FLNA ANK3 NSF SPTAN1 RAB11FIP1 YTHDC1 NRP1 FAT1 CLPB PDP1 NISCH NUS1 VPS13A OSBPL11 TJP2 ADGRE5 OCLN ARHGAP21 TOP2B TPD52

3.27e-06119910520int:RHOA
InteractionRHOB interactions

PAG1 ANK3 NSF SPTAN1 FCHO2 RAB11FIP1 FAT1 NISCH NUS1 VPS13A OSBPL11 TJP2 ADGRE5 OCLN ARHGAP21 TOP2B

6.99e-0684010516int:RHOB
InteractionOCLN interactions

UNC13B ANK3 SPTAN1 FCHO2 RAB11FIP1 NRP1 NISCH TJP2 ADGRE5 OCLN SDC1 ARHGAP21

1.15e-0550010512int:OCLN
InteractionLYN interactions

PAG1 ANK3 SPTAN1 FCHO2 TEC RAB11FIP1 BLK CD22 NISCH VPS13A OSBPL11 OCLN ARHGAP21 TOP2B

2.21e-0572010514int:LYN
InteractionDLG5 interactions

ANK3 ACTR3 NRP1 NDC80 TJP2 GAN OCLN

3.81e-051761057int:DLG5
GeneFamilyAdenosine deaminase family

AMPD1 AMPD3

2.26e-0467121302
GeneFamilyAAA ATPases

NSF KATNA1 CLPB

1.18e-0353713413
GeneFamilyAnaphase promoting complex |Tetratricopeptide repeat domain containing

ANAPC5 ANAPC4

1.34e-0314712402
GeneFamilyUbiquitin specific peptidases

USP19 USP26 USP1

1.39e-0356713366
GeneFamilyCadherin related

CDHR2 FAT1

1.99e-031771224
CoexpressionLAKE_ADULT_KIDNEY_C5_PROXIMAL_TUBULE_EPITHELIAL_CELLS_STRESS_INFLAM

UNC13B SLC26A3 ACACB ZC3H13 DAB1 PLEKHA6 YTHDC1 ZC3H6 NRP1 CHD6 TPD52 TMEM63A

1.29e-0741710612M39224
CoexpressionMURARO_PANCREAS_DUCTAL_CELL

FOXO3 FLNA ANK3 SPTAN1 CPA3 RAB11FIP1 ACTR3 NRP1 KRT23 PPARGC1A PARP4 FAT1 PDP1 TJP2 OCLN PGM2 SDC1 ARHGAP21 TOP2B DYNC1I2

1.72e-07127610620M39173
CoexpressionGSE4142_PLASMA_CELL_VS_MEMORY_BCELL_UP

SLC26A3 CDHR2 BARD1 ZC3H6 SYTL3 PDP1 ADGRE5 USP1

1.53e-061991068M6395
CoexpressionPYEON_CANCER_HEAD_AND_NECK_VS_CERVICAL_UP

FMR1 ZGRF1 BARD1 OSBPL11 OCLN ANAPC5 GEN1

1.48e-051951067M13736
CoexpressionGSE22886_IGG_IGA_MEMORY_BCELL_VS_BLOOD_PLASMA_CELL_UP

SPTAN1 RAB11FIP1 KATNA1 MMP20 TBC1D4 CD22 OCLN

1.69e-051991067M4444
CoexpressionHADDAD_B_LYMPHOCYTE_PROGENITOR

FMR1 BARD1 BLK CD22 VPS13A ANAPC5 TOP2B TPD52

2.41e-052901068M939
CoexpressionLAZARO_GENETIC_MOUSE_MODEL_HIGH_GRADE_LARGE_CELL_NEUROENDOCRINE_LUNG_CARCINOMA_UP

ZGRF1 BARD1 SMC2 FAT1 NDC80 DSCC1 USP1 GEN1 SDC1

3.80e-054021069MM454
CoexpressionYAUCH_HEDGEHOG_SIGNALING_PARACRINE_UP

SLC26A3 ZC3H13 L1TD1 IGHG3 IGHG4 STK33

4.69e-051591066MM777
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AFF3 SCEL CCDC141 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

1.82e-101561099d81e78bec5c8a3f3ec9e1447ebab2c5805b815eb
ToppCellmild_COVID-19_(asymptomatic)-B_intermediate|World / disease group, cell group and cell class (v2)

AFF3 BLK CD22 SH3PXD2A IGHG3 IGHG4 GEN1 TPD52

6.01e-0916010986722934e153b72039c3c4308557d0ef879a30638
ToppCellmild_COVID-19_(asymptomatic)-B_intermediate|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

AFF3 BLK CD22 SH3PXD2A IGHG3 IGHG4 GEN1 TPD52

8.02e-0916610988de8f388f24436b84e19ef460476fdbda4d16abf
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-14|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

1.72e-081831098ffa831f67ed005f05d1b80ebc707e046fc08e22f
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

1.72e-08183109801664fce6b70a02c9d39d747b6a6aabc86d57bc2
ToppCellHealthy_donor-B_memory|World / disease group, cell group and cell class (v2)

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

2.03e-0818710984f68e3243071a4549c80aff8bff32c6ad892ee7f
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-B_lymphocytic|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

AMPD1 AFF3 BLK CD22 IGHG3 IGHG4 SDC1 TPD52

2.12e-081881098c3cae529fdbeb233d2b32bcc3537a8aba26a7dc2
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-lymphocytic-B_lymphocytic|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

AMPD1 AFF3 BLK CD22 IGHG3 IGHG4 SDC1 TPD52

2.30e-081901098a21d0c574abf21e7cb865a21a48f29c92d055fbe
ToppCellControl-Lymphoid_B-B_intermediate|Control / Disease group, lineage and cell class

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

2.40e-0819110980082181dbc39c7c4fd3aa34c3ed61439548e844b
ToppCellB_cells|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

AFF3 RAB11FIP1 BLK CD22 IGHG3 IGHG4 SDC1 TPD52

2.40e-08191109872e3191990973440e4f91427208df360f73e4f41
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_intermediate-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

2.50e-081921098f9f64ad7bab1433e9a45adb7db7f43ce3f591b47
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_intermediate|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

2.50e-0819210984884fd8ffa6fd6c30d7ac6bf447456b3397eabc5
ToppCellHealthy/Control-B_intermediate|World / Disease group and Cell class

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

2.50e-0819210982266aa695955f5d885708e6bc0d5a8827c306223
ToppCellHealthy_donor-B_intermediate|World / disease group, cell group and cell class (v2)

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

2.50e-081921098f77007b284e11f8654ad599eef929df7c6c4ebf0
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_intermediate|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

2.60e-0819310988f1d6024ef092923321e6efd441b8d476db70aed
ToppCellHealthy_donor-B_intermediate|Healthy_donor / disease group, cell group and cell class (v2)

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

2.60e-081931098e2be57bf3cbbbbff64853f06b9c11b136f73eea7
ToppCellsevere_COVID-19-B_intermediate|World / disease group, cell group and cell class (v2)

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

2.71e-081941098cb346cb186fe80a8f490ae90b2539b3543ba0ca9
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-B_lymphocytic|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

AMPD1 AFF3 BLK CD22 IGHG3 IGHG4 SDC1 TPD52

2.71e-0819410989b134a6e51b8556a04c362967fa474f8a7f59920
ToppCellHealthy/Control-B_intermediate|Healthy/Control / Disease group and Cell class

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

2.71e-0819410988a4260eeccb4924c392798b1ffa23cdd3a4062e9
ToppCellInfluenza-Influenza_Severe-Lymphocyte-B-B_intermediate|Influenza_Severe / Disease, condition lineage and cell class

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

3.17e-081981098ab622fee61714471af3a7be0af356e8a484dcaff
ToppCellControl-Control-Lymphocyte-B-B_intermediate|Control / Disease, condition lineage and cell class

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

3.30e-081991098ee6f07eec7edfe41d2f7fcb0b509ce00e99a6a95
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_memory-B_memory-6|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SCEL BLK CD22 IGHG3 IGHG4 GEN1 C13orf42

8.52e-0814910972cd860b96ed4be4d26844085d464961c1418054a
ToppCellICU-SEP-Lymphocyte-B-B_intermediate|ICU-SEP / Disease, Lineage and Cell Type

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 TPD52

2.18e-0717110972e44bf6f3d90193e7cadcac48bb852bd632a81bc
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

AFF3 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

2.18e-071711097a2938e56cb5749004317798dc7ac0f0c2d4d8ae0
ToppCellInfluenza_Severe-B_intermediate|Influenza_Severe / Disease group and Cell class

AFF3 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

2.45e-0717410974276bdaac53aebd3084323a90ecde572d3177446
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RAB11FIP1 BLK CD22 IGHG3 ITSN2 GEN1 TPD52

2.45e-071741097ebe6ce173ad12d4a2afa39f8d6185c0e4f97fb1e
ToppCellPND03-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLC26A3 CPA3 TEC NDC80 SYTL3 DSCC1 GEN1

2.65e-0717610971f8d5a48fedbb4c86272c9b5a0f1ef573350357b
ToppCellmild_COVID-19_(asymptomatic)-B_memory|World / disease group, cell group and cell class (v2)

ANK3 NEXMIF AFF3 BLK CD22 IGHG3 IGHG4

2.75e-071771097057871e211c6508b2a679d391f3cf0ac7ccfc628
ToppCellCTRL-Lymphoid-B_cell|CTRL / Disease state, Lineage and Cell class

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 TPD52

2.97e-071791097dd4055c0a8360ea10323ef6249519a6ae08fc05a
ToppCellCOVID-19_Moderate-B_intermediate|World / disease group, cell group and cell class

AFF3 CCDC141 BLK CD22 IGHG3 GEN1 TPD52

3.08e-071801097bd81b87a6dc81e5ab4a6c948eb0c80f14401a6a7
ToppCellsevere_influenza-B_memory|severe_influenza / disease group, cell group and cell class (v2)

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 TPD52

3.20e-07181109792e572c92109a6dae0f73138c57c3bbd2e0a2f36
ToppCellBAL-Mild-Lymphocyte-B|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 TPD52

3.20e-071811097700adfb41e4e377530f0dd31be89e12f109f3469
ToppCellControl-Lymphoid-B|World / Disease state, Lineage and Cell class

AFF3 PLEKHA6 BLK CD22 IGHG3 IGHG4 TPD52

3.20e-0718110979124f1a610cfc3355ad87921cd3eb5346956475d
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

AFF3 BLK CD22 IGHG3 IGHG4 ITSN2 TPD52

3.20e-0718110970bc58c8942491e7ee5b858c5742770df7677532f
ToppCell(2)_B_cells|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

AMPD1 AFF3 BLK CD22 IGHG3 IGHG4 TPD52

3.32e-0718210978fe9b3a82159a388ffb642ac4f6aff05b8b5f944
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

AFF3 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

3.32e-0718210979c120ddd109103ef6fac9c32b84d16a7624d0580
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-6|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AFF3 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

3.45e-07183109782fe14fc7039415de41bdfd615a1380bed99f560
ToppCellMild_COVID-19-B_cell|Mild_COVID-19 / Disease group,lineage and cell class (2021.01.30)

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 TPD52

3.45e-071831097dea119e2988e954475f557f0bbe12556a83e81a4
ToppCellHealthy/Control-B_memory|World / Disease group and Cell class

AFF3 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

3.58e-0718410979e1879d86b535ede9b47deb0752e291f987a5d5e
ToppCellBAL-Mild-Lymphocyte-B-B_cell-B_cell|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 TPD52

3.58e-0718410973f8a359e40bebe58545f708682e5e5d1b70cf5cb
ToppCellBAL-Mild-Lymphocyte-B-B_cell-B_cell-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 TPD52

3.58e-07184109764bede8db709fd32f40c03265b96f0b12155bb8a
ToppCellBAL-Mild-Lymphocyte-B-B_cell|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 TPD52

3.71e-071851097609080adb2cfb105bb7b8efb617553833299f371
ToppCelltumor_Lung-B_lymphocytes|tumor_Lung / Location, Cell class and cell subclass

AMPD1 AFF3 BLK CD22 IGHG3 IGHG4 TPD52

3.85e-071861097a54b368d7921185c583e35b532a6898c5486c2fc
ToppCellMild_COVID-19-B_cell-B_cell|Mild_COVID-19 / Disease group,lineage and cell class (2021.01.30)

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 TPD52

3.85e-071861097855a5a00ba2aa1b5c63b8db56d026ddecc546050
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AFF3 CCDC141 BLK CD22 IGHG3 GEN1 TPD52

3.85e-071861097d7d884ff4184636081c350d29f797bd923c6a3b4
ToppCellsevere_influenza-B_intermediate|severe_influenza / disease group, cell group and cell class (v2)

AFF3 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

3.99e-071871097d6db8595aa72fdabc4a056ba6ce09876868a66d5
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-6|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AFF3 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

4.14e-07188109718d16e3f095a109b6a690f46fe7fcd5674c3636b
ToppCellHealthy/Control-B_memory|Healthy/Control / Disease group and Cell class

AFF3 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

4.14e-0718810973aff07f77b2b15e7a30e47b30115178abe64474e
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

AFF3 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

4.29e-0718910972b53dae0e6e85b7139f8a9872fbebb3705b2f1bf
ToppCellCF-Lymphoid-B_cell|CF / Disease state, Lineage and Cell class

AFF3 CCDC141 BLK IGHG3 IGHG4 GEN1 TPD52

4.44e-071901097374d8fd63c733178acab07682ed1519693efab45
ToppCellHealthy_donor-B_memory|Healthy_donor / disease group, cell group and cell class (v2)

AFF3 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

4.44e-07190109746104a521f00d399315deca86699cb261b2795d6
ToppCellCOVID-19_Severe-B_intermediate|World / disease group, cell group and cell class

AFF3 CCDC141 BLK CD22 IGHG3 GEN1 TPD52

4.60e-071911097f226fd69a26124ba98e4544f550b89a08e6a3708
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_intermediate|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AFF3 CCDC141 BLK CD22 IGHG3 GEN1 TPD52

4.94e-0719310977cc10e8b51091869d46e462f3214999e7b5348b1
ToppCelldroplet-Bladder-nan-3m-Epithelial-bladder_urothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK3 RAB11FIP1 KRT23 PPARGC1A OCLN SDC1 TPD52

4.94e-071931097ee91a796d0f6d4cee7a93a525689e716fdceeda5
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_intermediate|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

AFF3 CCDC141 BLK CD22 IGHG3 GEN1 TPD52

5.11e-0719410972b61023a602d336ed0de174e9141046173db34e6
ToppCellControl-Lymphoid-Plasma,_B_cells|Control / Condition, Lineage and Cell class

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 TPD52

5.11e-07194109731fff4361ebed6308b1e6b2b705ee6e0a695bd0c
ToppCellCOVID-19_Mild-Lymphoid_B-B_intermediate|COVID-19_Mild / Disease group, lineage and cell class

AFF3 CCDC141 BLK CD22 IGHG3 GEN1 TPD52

5.11e-071941097bf6f72a489c62cbf1a679552d8c5eaaaa0b99d33
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_intermediate-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

AFF3 CCDC141 BLK CD22 IGHG3 GEN1 TPD52

5.11e-071941097f2486b19ac52a48d19f80b38a5536bee3dad745b
ToppCellPBMC-Severe-Lymphocyte-B|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

AFF3 BLK CD22 IGHG3 IGHG4 SDC1 TPD52

5.11e-0719410977dbedbdece4271e10134c9338c85cb3e04484c75
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

NSF AFF3 RAB11FIP1 CCDC141 BLK CD22 GEN1

5.11e-071941097d852aebf7a763b9a776c4570711f0c759f591910
ToppCellPBMC-Severe-Lymphocyte-B|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AFF3 BLK CD22 IGHG3 IGHG4 SDC1 TPD52

5.11e-071941097bd2c53fb064edfec76abe56a9ffaced0bda32ab0
ToppCellHealthy-B_intermediate|Healthy / disease group, cell group and cell class

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 TPD52

5.11e-071941097aabee48bf689367edae2079b4b90d253715f1097
ToppCellPBMC-Convalescent-Lymphocyte-B|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AFF3 BLK CD22 IGHG3 IGHG4 SDC1 TPD52

5.29e-07195109707852aab50a2ece9938334301f0a9d7181da06b8
ToppCellSepsis-Bac-SEP-Lymphocyte-B-B_intermediate|Bac-SEP / Disease, condition lineage and cell class

ANK3 BLK CD22 IGHG3 IGHG4 DZIP3 TPD52

5.48e-0719610971611920211beb1a3691e3853e0314792a74279a0
ToppCellPBMC-Convalescent-Lymphocyte-B|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)

AFF3 BLK CD22 IGHG3 IGHG4 SDC1 TPD52

5.48e-0719610975e5928fc218859317860fc387928127ac8009ba8
ToppCellBronchial-10x5prime-Immune_Lymphocytic-B|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

AMPD1 AFF3 BLK CD22 IGHG3 IGHG4 TPD52

5.67e-07197109788b29d205237f07a9a26cc15a1cf4ed4816a4c4b
ToppCellmild_COVID-19-B_intermediate|mild_COVID-19 / disease group, cell group and cell class (v2)

AFF3 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

5.67e-071971097f669500120646f69355a6f920b892a6f2faeab63
ToppCellsevere_COVID-19-B_intermediate|severe_COVID-19 / disease group, cell group and cell class (v2)

AFF3 CCDC141 BLK CD22 IGHG3 GEN1 TPD52

5.67e-0719710973ba64850b344cb24a4d20d64392a0b2752950d40
ToppCellmild_COVID-19-B_intermediate|World / disease group, cell group and cell class (v2)

AFF3 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

5.67e-071971097e909b898b7458071f176b6c04356ea3540589153
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-B|COVID-19_Severe / Disease, condition lineage and cell class

AFF3 BLK CD22 IGHG3 IGHG4 SDC1 TPD52

5.86e-0719810971831a777dd996c25f637d551d754ec1b9c23feb2
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

UNC13B AFF3 SCEL FCHO2 CCDC141 STK33 OCLN

6.06e-071991097725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-B-B_intermediate|COVID-19_Mild / Disease, condition lineage and cell class

AFF3 CCDC141 BLK CD22 IGHG3 GEN1 TPD52

6.06e-0719910971c6a08d01f6c1a2a4b6587d3a4522efbd03275e1
ToppCell10x5'v1-week_14-16-Lymphocytic_B-B_lineage-pre_pro_B_progenitor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

PAG1 BARD1 SMC2 NDC80 DSCC1 USP1 TOP2B

6.06e-0719910978daf945fc93169b0a4fa3ef9f4a87eedd52e314a
ToppCellInfluenza-Influenza_Severe-Lymphocyte-B-B_memory|Influenza_Severe / Disease, condition lineage and cell class

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 TPD52

6.06e-071991097bf0285f68c9cb1417fc070abc3cb224d07407e0e
ToppCellSepsis-ICU-SEP-Lymphocyte-B-B_intermediate|ICU-SEP / Disease, condition lineage and cell class

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4 TPD52

6.06e-071991097160b0f9687a996c4fea2a1a66f225af386483951
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-B-B_intermediate|COVID-19_Severe / Disease, condition lineage and cell class

AFF3 BLK CD22 IGHG3 IGHG4 GEN1 TPD52

6.06e-071991097ad3c369a67926725917b771094f82ca6dd2af783
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-FOXM1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ZGRF1 BARD1 SMC2 NDC80 DSCC1 USP1 GEN1

6.27e-0720010974cfe08878a6981bf7b3567f9e82192d8f060ddde
ToppCellCOVID-19-COVID-19_Convalescent-Lymphocyte-B|COVID-19_Convalescent / Disease, condition lineage and cell class

AFF3 BLK CD22 IGHG3 IGHG4 SDC1 TPD52

6.27e-072001097dfd3a2d84022cd9ae52a8182b36a9064940a56af
ToppCellmild-B_intermediate|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

AFF3 CCDC141 BLK CD22 ITSN2 GEN1 TPD52

6.27e-072001097fe815824e9e4be3f3db73610e3814a7fd533da65
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AFF3 CCDC141 BLK CD22 STK33 TPD52

9.82e-0713410968707210b2a5d33baa1d204e9e2ed8921181cb309
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

AFF3 BLK CD22 IGHG3 IGHG4 GEN1

1.49e-061441096fca32b38d23fa4d213e553b929604a2796e9a929
ToppCell10x5'-Lung-Lymphocytic_B-ABC_aged-B_memory|Lung / Manually curated celltypes from each tissue

AFF3 CCDC141 BLK CD22 IGHG3 GEN1

2.66e-061591096d3202ddc291b8686dbe67690df13c7daffec2199
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-1|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AFF3 BLK CD22 IGHG3 IGHG4 GEN1

2.76e-0616010967ad065337ac802de52c15ee715f6b78a3eed0cef
ToppCellAdult-Immune-B_cell-D231|Adult / Lineage, Cell type, age group and donor

AMPD1 AFF3 BLK CD22 IGHG3 IGHG4

3.07e-0616310964f5821299b265663c7d0352b28285f56e1988841
ToppCellInfluenza_Severe-B_memory|Influenza_Severe / Disease group and Cell class

AFF3 CCDC141 BLK CD22 IGHG3 IGHG4

3.29e-06165109651172acaeb667b34b8b8c7878d67cfa0c4a2dffc
ToppCellBronchial_Brush-Immune-B_cells|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

AMPD1 AFF3 CCDC141 BLK CD22 IGHG3

3.78e-061691096dc388f660f69e37e517bf3243daf071ab138ee6e
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-FOXM1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZGRF1 BARD1 SMC2 NDC80 DSCC1 GEN1

3.78e-061691096e0607af8ae8609d43e26ff2a2cab92650bfcd5b7
ToppCellURO-Lymphocyte-B-B_intermediate|URO / Disease, Lineage and Cell Type

AFF3 BLK CD22 IGHG3 IGHG4 TPD52

3.91e-061701096e11d1510518cedabeece96d4adbb90999e6326fa
ToppCellPND07-Immune-Immune_Myeloid-Granulocytic-Basophil|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TDRD5 SLC26A3 CPA3 TEC TBC1D4 SYTL3

3.91e-061701096bca78719c17355772ad6c53ee75e459faf1d089f
ToppCellPND07-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TDRD5 SLC26A3 CPA3 TEC TBC1D4 SYTL3

3.91e-06170109640d863554ec98ae43f76511c1112859688846613
ToppCellChildren_(3_yrs)-Immune-B_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

AFF3 BLK CD22 IGHG3 IGHG4 TPD52

3.91e-061701096e421f9eedf74baffda1d03707a710ece4b777f29
ToppCellICU-NoSEP-Lymphocyte-B-B_intermediate|ICU-NoSEP / Disease, Lineage and Cell Type

BLK CD22 IGHG3 IGHG4 INPP5J TPD52

4.04e-061711096c6b8578577aef4fe79c1a8ca778a068052f2c9d4
ToppCellInfluenza_Severe-B_intermediate|World / Disease group and Cell class

BLK CD22 IGHG3 IGHG4 GEN1 TPD52

4.04e-0617110964d33e1dc1efc423dbdd5f4cca6d6440a68add8d0
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BARD1 SMC2 NDC80 DSCC1 ANAPC5 ZNF287

4.18e-0617210962b6cd84c946b1e800caba452ae70145ea285fec1
ToppCellControl-Lymphoid-B_Plasma|Control / Disease state, Lineage and Cell class

AMPD1 BLK IGHG3 IGHG4 SDC1 TPD52

4.18e-06172109661e33836b8cb0f347f3e699eb587a37073b6fa4c
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

UNC13B ANK3 SCEL CCDC141 STK33 OCLN

4.32e-061731096b799c06a6a5754668e789f70c0c8bc1508568575
ToppCellmild_COVID-19_(asymptomatic)-B_memory|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

ANK3 NEXMIF BLK CD22 IGHG3 IGHG4

4.32e-0617310969082ad77b44f65b72094df6e502cce81b62fe81a
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZGRF1 SMC2 MEIOSIN DSCC1 USP1 GEN1

4.47e-06174109666555c610251ea04f968c258e312d720c18e7cde
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_memory-B_memory-6|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AFF3 BLK CD22 IGHG3 IGHG4 GEN1

4.62e-0617510961b3510e9078eec7cfc5805043e435e9e5e0f0877
ToppCellAdult-Immune-B_cell|Adult / Lineage, Cell type, age group and donor

AMPD1 BLK CD22 IGHG3 IGHG4 TPD52

4.77e-0617610964aa00dcde907ad83d3aa4bb10439b7b5c4be1e5d
DiseaseMuscle AMP deaminase deficiency

AMPD1 AMPD3

1.25e-0521052C0268123
DiseaseAdenosine monophosphate deaminase deficiency

AMPD1 AMPD3

1.25e-0521052C2931781
Diseaseserum IgG measurement

AFF3 FCHO2 IGHG3

3.44e-05181053EFO_0004565
Diseasetyrosine-protein kinase TEC measurement

TEC TEC

7.49e-0541052EFO_0020830
Diseasenephrotic syndrome (implicated_via_orthology)

KIRREL3 FAT1 ITSN2

8.39e-05241053DOID:1184 (implicated_via_orthology)
Diseasepontocerebellar hypoplasia (implicated_via_orthology)

AMPD1 AMPD3

1.25e-0451052DOID:0060264 (implicated_via_orthology)
DiseaseParkinson's disease (implicated_via_orthology)

FOXO3 NSF PPARGC1A NUS1 VPS13A

2.52e-041571055DOID:14330 (implicated_via_orthology)
Diseaseinducible T-cell costimulator measurement

IGHG3 NUS1

2.60e-0471052EFO_0021967
Diseaserheumatoid arthritis, anti-citrullinated protein antibody seropositivity, rheumatoid factor seropositivity measurement

AFF3 TEC BLK TEC TPD52

3.63e-041701055EFO_0000685, EFO_0007791, EFO_0007837
Diseaseparental longevity

PAG1 NRP1 CEMIP PPARGC1A VPS13A ADGRE5 ZNF287 ANAPC4

3.94e-044941058EFO_0007796
Diseasewaist-hip ratio

FOXO3 AMPD3 ANK3 AFF3 COL5A3 ACTRT2 SCEL NRP1 CEMIP PBRM1 NISCH POC5 ARHGAP21

4.16e-04122610513EFO_0004343
DiseaseMalignant neoplasm of breast

FLNA SPTAN1 BARD1 PKDREJ PBRM1 NISCH ITSN2 OSBPL11 OCLN GKN1 ANAPC5 GEN1

4.42e-04107410512C0006142
Diseaseseasonality measurement

TJP2 SDC1

8.09e-04121052EFO_0006876
Diseasewaist circumference

FOXO3 DAB1 SMARCAD1 SLC10A2 KAT8 MEIOSIN POC5

8.76e-044291057EFO_0004342
Diseasebrain volume measurement

FOXO3 AMPD3 NSF ACTRT2 VIT KATNA1 SLC10A2 SH3PXD2A

1.31e-035951058EFO_0006930
Diseaserheumatoid arthritis

AFF3 TEC BLK SH3PXD2A TEC ANAPC4 TPD52

1.34e-034621057EFO_0000685
Diseaseobesity (biomarker_via_orthology)

FOXO3 ACACB PPARGC1A SDC1

1.91e-031471054DOID:9970 (biomarker_via_orthology)
Diseasecystathionine measurement

TEC TEC

2.06e-03191052EFO_0010474
Diseasealbumin:globulin ratio measurement

AFF3 FCHO2 BLK

2.27e-03731053EFO_0005128
Diseasemucocutaneous lymph node syndrome

DAB1 BLK TPD52

2.55e-03761053EFO_0004246
Diseaseepilepsy (implicated_via_orthology)

UNC13B RIPK1 NSF NUS1

2.78e-031631054DOID:1826 (implicated_via_orthology)
Diseasecomplex trait

VIT CCDC141 KAT8 CHD6 USP1

2.88e-032711055EFO_0010578
Diseaseelectrocardiography

DAB1 PLEKHA6 CCDC141 CEMIP PPARGC1A CLPB SH3PXD2A

2.91e-035301057EFO_0004327
Diseasesmall cell lung carcinoma

FCHO2 NRP1 STK33

2.95e-03801053EFO_0000702
Diseasespermatogenic failure (is_implicated_in)

USP26 C2CD6

3.02e-03231052DOID:0111910 (is_implicated_in)
DiseaseCleft palate, cleft lip

VAX1 CEMIP SH3PXD2A PDP1 POC5

3.26e-032791055EFO_0003959, HP_0000175
Diseasethyroxine measurement

ZGRF1 PPARGC1A KIRREL3

3.27e-03831053EFO_0005130
Diseasebrain stem volume measurement

FOXO3 KATNA1

3.29e-03241052EFO_0010605

Protein segments in the cluster

PeptideGeneStartEntry
YFNEDRKISPQSKES

TDRD5

701

Q8NAT2
KNSKPNELESVYSGD

USP26

631

Q9BXU7
IDYFKNSSKAAQAPS

AFF3

1091

P51826
PKNYSNTSKIFSEEN

ANAPC4

146

Q9UJX5
KDASAQQDSYEFVSP

BARD1

171

Q99728
APSAEANQKKYFVGE

ACTRT2

46

Q8TDY3
DKSKDFYPFGSNVQS

ADGB

21

Q8N7X0
EGYSIKPETNQNDTK

FCHO2

321

Q0JRZ9
GYEPVSGAKTFKNES

ADGRE5

96

P48960
TPKKYSQFSADVAEA

C13orf42

141

A0A1B0GVH6
RFDKFNDKYNPVGAS

AMPD1

371

P23109
GTFPYDDGSKQEIKN

CEMIP

821

Q8WUJ3
FDKFNSKYNPVGASE

AMPD3

386

Q01432
SNYVKPKDQESFGSA

ITSN2

1031

Q9NZM3
SSNGKVNDKRFYPES

OCLN

326

Q16625
PDSAYKTAQAVKDFN

ACACB

2131

O00763
QVASAASYDQPKKAE

ANAPC5

671

Q9UJX4
KSYTNVPADDVSGNK

RSPH10B

646

P0C881
KSYTNVPADDVSGNK

RSPH10B2

646

B2RC85
DNASPKFTSKEYSVE

FAT1

1661

Q14517
AGIDSTNNKKEEYGP

POC5

376

Q8NA72
AKNAKTYNEPGSQVF

PBRM1

256

Q86U86
TYNEPGSQVFKDANS

PBRM1

261

Q86U86
YAEKGTNKTNFTSIP

KCND1

346

Q9NSA2
YFSKEKESPDGNNVA

KAT8

301

Q9H7Z6
TKNNKPLYSFEDNAD

DYNC1I2

511

Q13409
PEVNKQRESYSGKFT

C2CD6

576

Q53TS8
KYSPEFANSNDKDDQ

NUS1

166

Q96E22
PSASINNDYFEDLKK

PGM2

221

Q96G03
RDPGSKKDYSQYEEN

KRT23

111

Q9C075
FLQKKSIDSNPYDTD

NSF

101

P46459
NFSKVEDYQLPDAKT

PARP4

591

Q9UKK3
LNYKTEEPASDKGSE

TMEM63A

726

O94886
AYTQEAPQEKDTASK

MEIOSIN

406

C9JSJ3
ANEYSFKVPEFDGKN

PDP1

91

Q9P0J1
KNLKYPGENDQSFSG

DZIP3

296

Q86Y13
SNSDDFDPASTKSKY

PPARGC1A

766

Q9UBK2
KAKSFEGNNNYDTPE

NRP1

536

O14786
PDLVKEFNKYDTDGS

ACTR3

236

P61158
NQSSYNFTVKEEDPG

CDHR2

696

Q9BYE9
YSVNPNKVDDLSKFG

GKN1

121

Q9NS71
KKAVGAFSVTYDPEN

FMR1

151

Q06787
NYRGSAPESEKETKA

CPA3

271

P15088
PYEGPDSQKEKDSNS

DSCC1

146

Q9BVC3
NKTSDSFLNYPSDKV

CCDC141

966

Q6ZP82
KSQPVSNGYSFEDFE

DAB1

236

O75553
SQDYPGKYSEEESKS

CHD6

2041

Q8TD26
AKSPFEVYVDKSQGD

FLNA

366

P21333
ENKQTLSSGEKYDPD

GAN

336

Q9H2C0
DSEYTAQEGAKFPIK

BLK

386

P51451
AKTKSYFPESQNDVG

ANK3

4261

Q12955
YFPESQNDVGKQSTK

ANK3

4266

Q12955
SSDEQSAPVFGKAKY

GEN1

801

Q17RS7
KDPTNGYYSVNTFKE

KIRREL3

631

Q8IZU9
KSNAGADAETKEPKY

KIAA1210

1601

Q9ULL0
EPETNKFDSTGYDKD

KATNA1

176

O75449
GDDFSSVYKTAKEQG

CLPB

196

Q9H078
NAKTKPREEQYNSTF

IGHG3

216

P01860
NAKTKPREEQFNSTY

IGHG4

166

P01861
YTTSKFNDAEPAKGN

CFAP47

1471

Q6ZTR5
KKFSYVDADGSPVNV

COL5A3

1616

P25940
STIKPYNAEDNENFK

CZIB

81

Q9NWV4
NPEYNKNTSKFDGTR

CD22

61

P20273
YKNGADQPFATDQSK

OSBPL11

306

Q9BXB4
KENGTEPESSFYKAN

SLC10A2

326

Q12908
ENNSISSIPEKYFDK

OMD

241

Q99983
KDYPKNTEEEFSGVN

MMP20

426

O60882
QPSDSYAQDQGKFIS

OR2G3

261

Q8NGZ4
VPYFKDKGDSNSSAG

FOXO3

191

O43524
KFDKGDNSSQQDPAT

RTL4

151

Q6ZR62
KAEKYEDSVPQSNGE

SYTL3

436

Q4VX76
CKKQDYSPSSGEAQE

RAB11FIP1

711

Q6WKZ4
EKQSTAYEKQFPATS

STK33

446

Q9BYT3
AYEKQFPATSKDNFD

STK33

451

Q9BYT3
PSYSQKSEDDSAKFD

TOP2B

1451

Q02880
KRKASGSENEGDYNP

TOP2B

1546

Q02880
TPDNERKASISYFKN

SMARCAD1

71

Q9H4L7
DDQYTSSSGAKFPVK

TEC

516

P42680
PGYNEDSRSTFFDKK

NEXMIF

1416

Q5QGS0
KQAIDESTNGFTYKP

PKDREJ

1846

Q9NTG1
KDEGSYSLEEPKQAN

SDC1

281

P18827
YSTSKFNPSQEKDGK

SLC26A3

726

P40879
VNAKPTEKSDVYSFA

RIPK1

201

Q13546
NDLYATVKDFEKTPN

PAG1

356

Q9NWQ8
PTFKFDVGTNKYDTS

INPP5J

656

Q15735
GSNEPKANYEQSKKD

PLEKHA6

721

Q9Y2H5
NLAFVKNDSYEKGPD

USP19

281

O94966
PKAKTQNKEESYDFS

TJP2

996

Q9UDY2
KSYEYKSNPSAVAGN

TJP2

1011

Q9UDY2
FSVSDDFQEYNKPGK

ZC3H6

241

P61129
YEKDGSASPAVTKDQ

VPS13A

1341

Q96RL7
KSDKAQSGPYNVEKE

ZNF287

21

Q9HBT7
LYKPDSNEFAVGTKN

SAGE1

776

Q9NXZ1
PYTSQSKDEIGFEKG

SH3PXD2A

276

Q5TCZ1
ENSKSPKDGYQENIS

SCEL

586

O95171
ATDEAYKDPSNLQGK

SPTAN1

596

Q13813
EPVDKDFYSEFGNKT

NISCH

1286

Q9Y2I1
KSPAAQAGETTKAYQ

VIT

156

Q6UXI7
AKFQGSPDKFNTYVT

UNC13B

11

O14795
QPGDDVVSNYFTKGK

TEX261

156

Q6UWH6
YNPESEQDKNEKKGS

YTHDC1

31

Q96MU7
PNSAYDFKTNNPKEA

SMC2

951

O95347
AKPSKDNEDAFYNSQ

TBC1D4

186

O60343
TDAVYGDNKEDANKP

ZGRF1

651

Q86YA3
KDFSPKNVIYDDSSQ

ZNF140

86

P52738
DYQSPFDFDAGVNKS

TPD52

11

P55327
QPNSKTERSKSYDEG

ARHGAP21

871

Q5T5U3
YNKASNPDKVASTAF

USP1

681

O94782
PDSDAYNSGDDKNEK

ZC3H13

846

Q5T200
FEPYSRTNNKEGAEK

VAX1

316

Q5SQQ9
EYNSNDGKKLPQGES

L1TD1

151

Q5T7N2
EFSAGTVYPETNKTK

N4BP1

396

O75113
NSKGYDFEIKFNPEA

NDC80

431

O14777