Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	regulation of mitotic spindle assembly	CHMP1B CHMP2B DRG1 CHMP3	3.88e-05	24	167	4	GO:1901673
GeneOntologyBiologicalProcess	viral budding	CHMP1B LRSAM1 CHMP2B CHMP3	5.39e-05	26	167	4	GO:0046755
GeneOntologyBiologicalProcess	calcium-ion regulated exocytosis	RIMS3 ARHGAP17 UNC13D SYT15 STXBP3 RIMS2	5.42e-05	82	167	6	GO:0017156
GeneOntologyBiologicalProcess	mitotic nuclear division	KNTC1 OFD1 CHMP1B SMC2 KIF20B EDN1 CHMP2B DRG1 CHEK2 CHMP3 ESPL1	5.55e-05	316	167	11	GO:0140014
GeneOntologyBiologicalProcess	mitotic sister chromatid segregation	KNTC1 OFD1 CHMP1B SMC2 CHMP2B DRG1 CHEK2 CHMP3 ESPL1	5.95e-05	212	167	9	GO:0000070
GeneOntologyBiologicalProcess	cytoskeleton-dependent cytokinesis	NOX5 CHMP1B KIF20B CHMP2B CHMP3 EXOC1 ESPL1	7.96e-05	127	167	7	GO:0061640
GeneOntologyBiologicalProcess	mitotic spindle assembly	OFD1 CHMP1B CHMP2B DRG1 CHEK2 CHMP3	1.03e-04	92	167	6	GO:0090307
GeneOntologyBiologicalProcess	mitotic cytokinesis	CHMP1B KIF20B CHMP2B CHMP3 EXOC1 ESPL1	1.23e-04	95	167	6	GO:0000281
GeneOntologyBiologicalProcess	regulated exocytosis	NPPC ABR RIMS3 ARHGAP17 NR4A3 UNC13D SYT15 STXBP3 PLEK RIMS2	1.35e-04	291	167	10	GO:0045055
GeneOntologyBiologicalProcess	vesicle fusion with vacuole	CHMP1B CHMP2B CHMP3	1.40e-04	13	167	3	GO:0051469
GeneOntologyBiologicalProcess	multivesicular body-lysosome fusion	CHMP1B CHMP2B CHMP3	1.40e-04	13	167	3	GO:0061763
GeneOntologyBiologicalProcess	mitotic cytokinetic process	CHMP1B KIF20B CHMP2B CHMP3	1.41e-04	33	167	4	GO:1902410
GeneOntologyBiologicalProcess	microtubule cytoskeleton organization involved in mitosis	OFD1 CHMP1B CHMP2B DRG1 CHEK2 CHMP3 TACC1 ESPL1	1.46e-04	187	167	8	GO:1902850
GeneOntologyBiologicalProcess	regulation of spindle assembly	CHMP1B CHMP2B DRG1 CHMP3	1.59e-04	34	167	4	GO:0090169
GeneOntologyBiologicalProcess	vacuole fusion	CHMP1B CHMP2B CHMP3	1.78e-04	14	167	3	GO:0097576
GeneOntologyBiologicalProcess	viral budding from plasma membrane	CHMP1B CHMP2B CHMP3	1.78e-04	14	167	3	GO:0046761
GeneOntologyBiologicalProcess	virion assembly	CHMP1B LRSAM1 CHMP2B CHMP3	1.78e-04	35	167	4	GO:0019068
GeneOntologyBiologicalProcess	organelle localization	KNTC1 NPPC MYO1A CHMP1B NR4A3 UNC13D KAT2A TRAPPC8 CHMP2B STXBP3 CHMP3 TACC1 EXOC1 PLEK RIMS2 ESPL1	1.96e-04	703	167	16	GO:0051640
GeneOntologyBiologicalProcess	non-lytic viral release	CHMP1B CHMP2B CHMP3	2.21e-04	15	167	3	GO:0046753
GeneOntologyBiologicalProcess	exocytosis	NPPC ABR RIMS3 ARHGAP17 NR4A3 UNC13D SYT15 STXBP3 CHMP3 EXOC1 PLEK RIMS2	2.25e-04	434	167	12	GO:0006887
GeneOntologyBiologicalProcess	sister chromatid segregation	KNTC1 OFD1 CHMP1B SMC2 CHMP2B DRG1 CHEK2 CHMP3 ESPL1	2.34e-04	254	167	9	GO:0000819
GeneOntologyBiologicalProcess	mitotic spindle organization	OFD1 CHMP1B CHMP2B DRG1 CHEK2 CHMP3 TACC1	2.34e-04	151	167	7	GO:0007052
GeneOntologyCellularComponent	kinetochore microtubule	KNTC1 CHMP1B CHMP2B CHMP3	2.75e-05	22	170	4	GO:0005828
GeneOntologyCellularComponent	amphisome membrane	CHMP1B CHMP2B CHMP3	1.42e-04	13	170	3	GO:1904930
GeneOntologyCellularComponent	ESCRT III complex	CHMP1B CHMP2B CHMP3	1.80e-04	14	170	3	GO:0000815
GeneOntologyCellularComponent	amphisome	CHMP1B CHMP2B CHMP3	2.24e-04	15	170	3	GO:0044753
GeneOntologyCellularComponent	midbody	CHMP1B CNTRL KIF20B CHMP2B SSH1 CHMP3 TACC1 EXOC1	4.79e-04	222	170	8	GO:0030496
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	CUL2 APPBP2 PRAMEF17 GLMN	5.73e-04	47	170	4	GO:0031462
Pubmed	Parathyroid hormone induces the NR4A family of nuclear orphan receptors in vivo.	NR4A3 NR4A1 PTH	4.82e-07	4	173	3	15910753
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	CUL2 APPBP2 WASHC4 OFD1 POLA1 CNTRL TXNRD1 IBTK IGF2R STXBP3 STC2 RCBTB1 AGK ATP2B1 HDLBP	6.16e-06	754	173	15	33060197
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	NOC2L RPP38 SMC2 GTPBP10 KIF20B CHMP2B DHX30 DRG1 IBTK ZC3H11A AGK TMPO MACF1 ESPL1 DDX24	6.67e-06	759	173	15	35915203
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	CUL2 HSPA4L SMC2 GFPT1 RUFY3 DRG1 ZC3H11A STXBP3 NANS TMPO MACF1 HDLBP	8.25e-06	498	173	12	36634849
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	KNTC1 INPPL1 LRSAM1 SH3GLB2 ARHGAP17 CNTLN KIF20B RUFY3 N4BP2 MACF1 PPP2R3C TOP3A HDLBP	8.65e-06	588	173	13	38580884
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	KNTC1 ZNF280D HSPA4L NOC2L POLA1 SMC2 NDUFA10 GFPT1 DHX30 DRG1 GLMN ZC3H11A IGF2R STXBP3 AGK TMPO EEA1 MYO18B DDX24 ATP2B1 HDLBP	9.14e-06	1425	173	21	30948266
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	WASHC4 SPR NOC2L POLA1 LRSAM1 RPP38 SMC2 ARMCX1 KIF20B GFPT1 DHX30 ZC3H11A SBF1 NANS HLTF MACF1 EXOC1 DDX24 ATP2B1 HDLBP	1.45e-05	1353	173	20	29467282
Pubmed	Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission.	CHMP1B CHMP2B CHMP3	1.94e-05	11	173	3	36107470
Pubmed	Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease.	CHMP1B CHMP2B CHMP3	1.94e-05	11	173	3	17984323
Pubmed	The orphan nuclear receptor Nor1/Nr4a3 is a negative regulator of β-cell mass.	NR4A3 NR4A1	2.46e-05	2	173	2	30696767
Pubmed	NR4A3 induces endothelial dysfunction through up-regulation of endothelial 1 expression in adipose tissue-derived stromal cells.	NR4A3 EDN1	2.46e-05	2	173	2	33221345
Pubmed	NR4A3 Suppresses Lymphomagenesis through Induction of Proapoptotic Genes.	NR4A3 NR4A1	2.46e-05	2	173	2	28249906
Pubmed	Molecular signatures of thyroid follicular neoplasia.	NR4A3 NR4A1	2.46e-05	2	173	2	20668010
Pubmed	The nuclear orphan receptor NR4A1 and NR4A3 as tumor suppressors in hematologic neoplasms.	NR4A3 NR4A1	2.46e-05	2	173	2	25410408
Pubmed	Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia.	NR4A3 NR4A1	2.46e-05	2	173	2	17515897
Pubmed	Reduced NR4A gene dosage leads to mixed myelodysplastic/myeloproliferative neoplasms in mice.	NR4A3 NR4A1	2.46e-05	2	173	2	21205929
Pubmed	Investigation of the expression of genes affecting cytomatrix active zone function in the amygdala in schizophrenia: effects of antipsychotic drugs.	RIMS3 RIMS2	2.46e-05	2	173	2	18490030
Pubmed	Expressed sequence tags identify a human isolog of the suil translation initiation factor.	EIF1B EIF1	2.46e-05	2	173	2	7904817
Pubmed	Longitudinal transcriptomic analysis of altered pathways in a CHMP2Bintron5-based model of ALS-FTD.	CHMP2B ATP2B1	2.46e-05	2	173	2	31837425
Pubmed	Aberrant KAT2A accumulations render TRIM22-low melanoma sensitive to Notch1 inhibitors via epigenetic reprogramming.	KAT2A TRIM22	2.46e-05	2	173	2	37415153
Pubmed	Orphan nuclear receptor Nur77 is a novel negative regulator of endothelin-1 expression in vascular endothelial cells.	NR4A1 EDN1	2.46e-05	2	173	2	25284689
Pubmed	Protein kinase C regulates mitochondrial targeting of Nur77 and its family member Nor-1 in thymocytes undergoing apoptosis.	NR4A3 NR4A1	2.46e-05	2	173	2	20411565
Pubmed	A transgenic mouse expressing CHMP2Bintron5 mutant in neurons develops histological and behavioural features of amyotrophic lateral sclerosis and frontotemporal dementia.	CHMP2B ATP2B1	2.46e-05	2	173	2	27329763
Pubmed	Deficiency of the NR4A neuron-derived orphan receptor-1 attenuates neointima formation after vascular injury.	NR4A3 NR4A1	2.46e-05	2	173	2	19153266
Pubmed	HDAC inhibition by SNDX-275 (Entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML.	NR4A3 NR4A1	2.46e-05	2	173	2	23247046
Pubmed	Structure of cellular ESCRT-III spirals and their relationship to HIV budding.	CHMP1B CHMP2B CHMP3	2.57e-05	12	173	3	24878737
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	CUL2 NPPC HSPA4L NOC2L EIF1B SMC2 GTPBP10 DHX30 DRG1 TXNRD1 ZC3H11A RBMX2 TMPO DDX24 ATP2B1 HDLBP	3.05e-05	971	173	16	33306668
Pubmed	A global genomic transcriptional code associated with CNS-expressed genes.	CUL2 SOX11 POLA1 CNTLN CLDN10 TMPO DCLK2 RIMS2 L3MBTL4	3.33e-05	318	173	9	16919269
Pubmed	ESCRT machinery is required for plasma membrane repair.	CHMP1B CHMP2B CHMP3	3.33e-05	13	173	3	24482116
Pubmed	The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor.	CHMP1B CHMP2B CHMP3	3.33e-05	13	173	3	16554368
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	CUL2 KNTC1 SP100 WASHC4 HSPA4L POLA1 ACO1 INPPL1 LRSAM1 RPP38 SH3GLB2 UNC13D SMC2 UBR7 GFPT1 TXNRD1 NANS TJP2 MACF1 HDLBP	4.05e-05	1455	173	20	22863883
Pubmed	ESCRT-III controls nuclear envelope reformation.	CHMP1B CHMP2B CHMP3	4.23e-05	14	173	3	26040713
Pubmed	AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding.	CHMP1B CHMP2B CHMP3	5.27e-05	15	173	3	14505569
Pubmed	Membrane scission by the ESCRT-III complex.	CHMP1B CHMP2B CHMP3	5.27e-05	15	173	3	19234443
Pubmed	Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing.	CHMP1B CHMP2B CHMP3	5.27e-05	15	173	3	26040712
Pubmed	Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1.	CHMP1B CHMP2B CHMP3	5.27e-05	15	173	3	16505166
Pubmed	Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance.	CHMP1B CHMP2B CHMP3	5.27e-05	15	173	3	20616062
Pubmed	C-type natriuretic peptide (CNP)/guanylate cyclase B (GC-B) system and endothelin-1(ET-1)/ET receptor A and B system in human vasculature.	NPPC EDN1	7.36e-05	3	173	2	32268070
Pubmed	NR4A nuclear receptors support memory enhancement by histone deacetylase inhibitors.	NR4A3 NR4A1	7.36e-05	3	173	2	22996661
Pubmed	Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1.	NR4A3 NR4A1	7.36e-05	3	173	2	18945812
Pubmed	Orphan receptor TR3 participates in cisplatin-induced apoptosis via Chk2 phosphorylation to repress intestinal tumorigenesis.	NR4A1 CHEK2	7.36e-05	3	173	2	22159226
Pubmed	Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli.	NR4A3 NR4A1	7.36e-05	3	173	2	15964844
Pubmed	Structural basis for ESCRT-III CHMP3 recruitment of AMSH.	CHMP1B CHMP3	7.36e-05	3	173	2	21827950
Pubmed	Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin.	SSH1 SSH2	7.36e-05	3	173	2	14531860
Pubmed	Post-translational control of beige fat biogenesis by PRDM16 stabilization.	CUL2 APPBP2	7.36e-05	3	173	2	35978186
Pubmed	NR4A1 and NR4A3 restrict HSC proliferation via reciprocal regulation of C/EBPα and inflammatory signaling.	NR4A3 NR4A1	7.36e-05	3	173	2	29343483
Pubmed	Unc119 gene deletion partially rescues the GRK1 transport defect of Pde6d (- /-) cones.	PDE6D GRK1	7.36e-05	3	173	2	24664735
Pubmed	Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation.	NR4A3 NR4A1	7.36e-05	3	173	2	10523643
Pubmed	Orphan nuclear receptors in T lymphocyte development.	NR4A3 NR4A1	7.36e-05	3	173	2	12223510
Pubmed	Effects of endothelin-1 on release of adrenomedullin and C-type natriuretic peptide from individual human vascular endothelial cells.	NPPC EDN1	7.36e-05	3	173	2	12379507
Pubmed	Replicated association of the NR4A3 gene with smoking behaviour in schizophrenia and in bipolar disorder.	NR4A3 NR4A1	7.36e-05	3	173	2	20659174
Pubmed	B cell lymphoma 2 (Bcl-2) residues essential for Bcl-2's apoptosis-inducing interaction with Nur77/Nor-1 orphan steroid receptors.	NR4A3 NR4A1	7.36e-05	3	173	2	29414782
Pubmed	Nuclear Receptor Subfamily 4A Signaling as a Key Disease Pathway of CD1c+ Dendritic Cell Dysregulation in Systemic Sclerosis.	NR4A3 NR4A1	7.36e-05	3	173	2	36482877
Pubmed	NR4A transcription factors limit CAR T cell function in solid tumours.	NR4A3 NR4A1	7.36e-05	3	173	2	30814732
Pubmed	CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis.	CD2 IL7R	7.36e-05	3	173	2	21300823
Pubmed	The NR4A orphan nuclear receptors: mediators in metabolism and diseases.	NR4A3 NR4A1	7.36e-05	3	173	2	25089663
Pubmed	Beta-adrenergic signaling regulates NR4A nuclear receptor and metabolic gene expression in multiple tissues.	NR4A3 NR4A1	7.36e-05	3	173	2	19465082
Pubmed	MSKs are required for the transcription of the nuclear orphan receptors Nur77, Nurr1 and Nor1 downstream of MAPK signalling.	NR4A3 NR4A1	7.36e-05	3	173	2	15910281
Pubmed	Nuclear receptors of the NR4a family are not required for the development and function of follicular T helper cells.	NR4A3 NR4A1	7.36e-05	3	173	2	25899083
Pubmed	Genome-wide profiling reveals transcriptional repression of MYC as a core component of NR4A tumor suppression in acute myeloid leukemia.	NR4A3 NR4A1	7.36e-05	3	173	2	23552735
Pubmed	Altered NR4A Subfamily Gene Expression Level in Peripheral Blood of Parkinson's and Alzheimer's Disease Patients.	NR4A3 NR4A1	7.36e-05	3	173	2	27159982
Pubmed	The nuclear receptors NUR77, NURR1 and NOR1 in obesity and during fat loss.	NR4A3 NR4A1	7.36e-05	3	173	2	22143616
Pubmed	Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses.	NR4A3 NR4A1	7.36e-05	3	173	2	16873729
Pubmed	The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in mice.	NR4A3 NR4A1	7.36e-05	3	173	2	25605333
Pubmed	Relevance of the NR4A sub-family of nuclear orphan receptors in trophoblastic BeWo cell differentiation.	NR4A3 NR4A1	7.36e-05	3	173	2	28808448
Pubmed	The NR4A receptors Nurr1 and Nur77 are increased in human placenta from women with gestational diabetes.	NR4A3 NR4A1	7.36e-05	3	173	2	25199433
Pubmed	Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels.	CYP26A1 CYP39A1	7.36e-05	3	173	2	19553612
Pubmed	NR4A nuclear receptors in immunity and atherosclerosis.	NR4A3 NR4A1	7.36e-05	3	173	2	24005216
Pubmed	Deficiency of the NR4A orphan nuclear receptor NOR1 decreases monocyte adhesion and atherosclerosis.	NR4A3 NR4A1	7.36e-05	3	173	2	20558821
Pubmed	Minireview: What is Known about SUMOylation Among NR4A Family Members?	NR4A3 NR4A1	7.36e-05	3	173	2	34437889
Pubmed	Stress and glucocorticoid regulation of NR4A genes in mice.	NR4A3 NR4A1	7.36e-05	3	173	2	24753204
Pubmed	Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis.	NR4A3 NR4A1	7.36e-05	3	173	2	9155013
Pubmed	Differential regulation of Nr4a subfamily nuclear receptors following mast cell activation.	NR4A3 NR4A1	7.36e-05	3	173	2	21621845
Pubmed	Antithrombotic Effects of Nur77 and Nor1 Are Mediated Through Upregulating Thrombomodulin Expression in Endothelial Cells.	NR4A3 NR4A1	7.36e-05	3	173	2	26634653
Pubmed	Deletion of PrBP/delta impedes transport of GRK1 and PDE6 catalytic subunits to photoreceptor outer segments.	PDE6D GRK1	7.36e-05	3	173	2	17496142
Pubmed	PLCε, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart.	SSH1 PLCE1	7.36e-05	3	173	2	24345679
Pubmed	Nuclear receptor 4A (NR4A) family - orphans no more.	NR4A3 NR4A1	7.36e-05	3	173	2	25917081
Pubmed	FGF-8 stimulates the expression of NR4A orphan nuclear receptors in osteoblasts.	NR4A3 NR4A1	7.36e-05	3	173	2	18809462
Pubmed	Endothelium-specific endothelin-1 expression promotes pro-inflammatory macrophage activation by regulating miR-33/NR4A axis.	NR4A1 EDN1	7.36e-05	3	173	2	33340492
Pubmed	The protein network of HIV budding.	CHMP1B CHMP2B CHMP3	9.34e-05	18	173	3	14505570
Pubmed	Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins.	CHMP1B CHMP2B CHMP3	9.34e-05	18	173	3	14519844
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF355P ZNF175 ZNF208 ZNF814	1.05e-04	49	173	4	9630514
Pubmed	Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.	SORBS2 ZNF280D NOC2L FAM76B JKAMP TRAPPC8 KIF20B CHMP2B ANKRD13C RCBTB1 RASGRP3 DPY19L4 DDX24	1.05e-04	750	173	13	11230166
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ABR OFD1 INPPL1 ARHGAP17 KAT2A JADE1 MED13L DHX30 ZC3H11A IGF2R SBF1 SSH1 IFRD2 ESPL1 PPP2R3C TOP3A	1.38e-04	1105	173	16	35748872
Pubmed	IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs.	IL33 IL7R	1.47e-04	4	173	2	22198948
Pubmed	Structural basis for ESCRT-III protein autoinhibition.	CHMP1B CHMP3	1.47e-04	4	173	2	19525971
Pubmed	Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver.	ABCA9 ABCA8	1.47e-04	4	173	2	16445568
Pubmed	TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion.	NR4A3 NR4A1	1.47e-04	4	173	2	31152140
Pubmed	Trained immunity induced by high-salt diet impedes stroke recovery.	NR4A3 NR4A1	1.47e-04	4	173	2	37965920
Pubmed	ESCRT-III CHMP2A and CHMP3 form variable helical polymers in vitro and act synergistically during HIV-1 budding.	CHMP2B CHMP3	1.47e-04	4	173	2	23051622
Pubmed	Evaluation of mRNA Expressions of TOX and NR4As in CD8+ T cells in Acute Leukemia.	NR4A3 NR4A1	1.47e-04	4	173	2	37961948
Pubmed	Nr4a Receptors Regulate Development and Death of Labile Treg Precursors to Prevent Generation of Pathogenic Self-Reactive Cells.	NR4A3 NR4A1	1.47e-04	4	173	2	30089271
Pubmed	Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1.	NR4A3 NR4A1	1.47e-04	4	173	2	14525795
Pubmed	The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes.	SSH1 SSH2	1.47e-04	4	173	2	17848544
Pubmed	Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins.	RIMS3 RIMS2	1.47e-04	4	173	2	12620390
Pubmed	Nur77 attenuates endothelin-1 expression via downregulation of NF-κB and p38 MAPK in A549 cells and in an ARDS rat model.	NR4A1 EDN1	1.47e-04	4	173	2	27765761
Pubmed	Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice.	NR4A3 NR4A1	1.47e-04	4	173	2	23288947
Pubmed	CK2 involvement in ESCRT-III complex phosphorylation.	CHMP2B CHMP3	1.47e-04	4	173	2	24440309
Pubmed	Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis.	NR4A3 NR4A1	1.47e-04	4	173	2	23334790
Pubmed	Dual function of Pin1 in NR4A nuclear receptor activation: enhanced activity of NR4As and increased Nur77 protein stability.	NR4A3 NR4A1	1.47e-04	4	173	2	22789442
GeneFamily	Charged multivesicular body proteins\|ESCRT-III associated factors	CHMP1B CHMP2B CHMP3	4.30e-05	11	118	3	482
GeneFamily	Slingshot protein phosphatases	SSH1 SSH2	1.26e-04	3	118	2	898
GeneFamily	Regulating synaptic membrane exocytosis family\|PDZ domain containing	RIMS3 RIMS2	2.51e-04	4	118	2	833
GeneFamily	Charged multivesicular body proteins\|ESCRT-III	CHMP2B CHMP3	8.68e-04	7	118	2	1118
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	CUL2 SP100 APPBP2 WASHC4 FOXN3 MED13L TRAPPC8 KIF20B MAP3K4 TXNRD1 IBTK IGF2R STXBP3 HLTF TJP2 MACF1 ATP2B1 IL7R PLCE1	3.83e-06	856	172	19	M4500
Coexpression	KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_DN	CUL2 ABR INPPL1 MED13L PTH CLDN10 TXNRD1 IGF2R TJP2	4.09e-06	186	172	9	M1993
Coexpression	HEVNER_CORTEX_RADIAL_GLIA_PROGENITORS	KNTC1 POLA1 CNTRL CCDC80 PRDM5 UBR7 KIF20B STXBP3 CHEK2 TJP2 TACC1 PARPBP ESPL1	6.02e-06	432	172	13	MM419
Coexpression	PUJANA_XPRSS_INT_NETWORK	KNTC1 POLA1 CNTRL SMC2 KIF20B CHEK2 TMPO ESPL1	1.59e-05	168	172	8	M18811
Coexpression	GSE7219_WT_VS_NIK_NFKB2_KO_DC_DN	SP100 NLN RCBTB1 MACF1 EXOC1 PLEK ATP2B1 IL7R	1.66e-05	169	172	8	M379
Coexpression	GSE13547_2H_VS_12_H_ANTI_IGM_STIM_BCELL_UP	KNTC1 OFD1 CCDC146 HSPA4L GFPT1 TJP2 DCLK2 OSGIN2	2.23e-05	176	172	8	M2981
Coexpression	WU_SILENCED_BY_METHYLATION_IN_BLADDER_CANCER	FMO5 LAMA2 NR4A3 NR4A1 PLEK	2.32e-05	52	172	5	M19766
Coexpression	RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP	KNTC1 HSPA4L SMC2 GTPBP10 KIF20B GFPT1 ERCC8 NLN STC2 NETO2 HLTF TMPO PARPBP PPP2R3C IL7R	2.43e-05	644	172	15	M10501
Coexpression	LAKE_ADULT_KIDNEY_C30_IMMUNE_CELLS_MACROPHAGES	SP100 MED13L IL7R	3.22e-05	10	172	3	M39249
Coexpression	GSE13411_NAIVE_BCELL_VS_PLASMA_CELL_UP	SP100 ABR OFD1 STK17A CNTRL JADE1 SSH1 MACF1	4.80e-05	196	172	8	M3243
Coexpression	GSE11961_PLASMA_CELL_DAY7_VS_MEMORY_BCELL_DAY40_DN	FMO5 HSPA4L TRPC5 NR4A1 NETO2 NEK5 NXF3 ABCC2	5.15e-05	198	172	8	M9396
Coexpression	GSE2128_C57BL6_VS_NOD_CD4CD8_DP_THYMOCYTE_UP	ARSK NDUFA10 CHMP2B ZC3H11A NSUN3 TMPO EIF1 ATP2B1	5.15e-05	198	172	8	M6178
Coexpression	GSE24634_TREG_VS_TCONV_POST_DAY10_IL4_CONVERSION_UP	KNTC1 POLA1 SMC2 UBR7 TJP2 TMPO TACC1 ESPL1	5.34e-05	199	172	8	M4607
Coexpression	GSE39556_CD8A_DC_VS_NK_CELL_MOUSE_3H_POST_POLYIC_INJ_UP	KNTC1 POLA1 KIF20B CHEK2 HLTF TJP2 TMPO ESPL1	5.34e-05	199	172	8	M9419
Coexpression	GSE2128_CTRL_VS_MIMETOPE_NEGATIVE_SELECTION_DP_THYMOCYTE_C57BL6_DN	UNC13D MAP3K4 ADGB C7orf25 N4BP2 HLTF TJP2 PLCE1	5.53e-05	200	172	8	M6185
Coexpression	HALLMARK_TNFA_SIGNALING_VIA_NFKB	NR4A3 NR4A1 EDN1 LIF PLEK EIF1 ATP2B1 IL7R	5.53e-05	200	172	8	M5890
Coexpression	GSE13762_CTRL_VS_125_VITAMIND_DAY12_DC_UP	CUL2 TRIML2 HSPA4L NR4A1 KIF20B ULK3 DPY19L4	5.70e-05	148	172	7	M1892
Coexpression	YANG_BCL3_TARGETS_UP	KNTC1 NR4A3 JADE1 NR4A1 PARP14 KIF20B EDN1 ANKRD13C PARPBP ESPL1	7.45e-05	333	172	10	M2424
Coexpression	RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP	SP100 WASHC4 STK17A SMC2 GTPBP10 KIF20B GFPT1 TXNRD1 LIF ERCC8 NLN STC2 TMPO PPP2R3C ATP2B1	8.71e-05	721	172	15	M10237
Coexpression	PUJANA_BRCA2_PCC_NETWORK	MED20 KNTC1 POLA1 CNTRL SMC2 KIF20B GLMN CHEK2 HLTF TMPO ESPL1	1.25e-04	426	172	11	M9516
Coexpression	PUJANA_BRCA_CENTERED_NETWORK	MED20 POLA1 SMC2 CHEK2 TMPO ESPL1	1.31e-04	118	172	6	M15305
Coexpression	NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP	APPBP2 WASHC4 RIMS3 CNTRL RPP38 ARHGAP17 NR4A3 TRAPPC8 UBR7 RUFY3 GLMN IBTK C7orf25 TMPO ZNF814 MACF1 TACC1 EEA1 PPP2R3C TOP3A	1.48e-04	1215	172	20	M41122
Coexpression	AMIT_EGF_RESPONSE_120_MCF10A	TXNRD1 LIF NSUN3 EIF1	1.50e-04	41	172	4	M3471
Coexpression	FAN_EMBRYONIC_CTX_NSC_2	CNTRL JADE1 SMC2 KIF20B CHEK2 TMPO PARPBP ESPL1	1.60e-04	233	172	8	M39036
Coexpression	HE_LIM_SUN_FETAL_LUNG_C2_CYCLING_DC_CELL	MED20 CUL2 KNTC1 NOC2L POLA1 FAM76B JADE1 CNTLN SMC2 UBR7 KIF20B TXNRD1 GLMN CD2 N4BP2 IFRD2 CHEK2 HLTF AGK PARPBP ESPL1 TOP3A	1.66e-04	1423	172	22	M45722
CoexpressionAtlas	dev gonad_e11.5_F_PrimGermCell_Oct_k-means-cluster#3_top-relative-expression-ranked_1000	CUL2 KNTC1 TRIML2 POLA1 RPP38 JADE1 GTPBP10 UBR7 KIF20B CFAP20DC NANS CHEK2 HLTF DCLK2 OSGIN2 RIMS2 ESPL1	1.71e-07	463	168	17	gudmap_dev gonad_e11.5_F_PrimGermCell_Oct_k3_1000
CoexpressionAtlas	DevelopingKidney_e15.5_Cap mesenchyme_emap-27738_top-relative-expression-ranked_1000	SOX11 SORBS2 ABR HSPA4L SMC2 PRDM5 KIF20B RUFY3 DHX30 IBTK NETO2 SLC9B2 HLTF UMOD TNKS2 OSGIN2 EIF1 PARPBP RIMS2 PPP2R3C IL33	9.74e-07	779	168	21	gudmap_developingKidney_e15.5_Cap mesenchyme_1000
CoexpressionAtlas	DevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_k-means-cluster#5_top-relative-expression-ranked_500	SORBS2 CNTRL SMC2 IBTK DCAF17 TNKS2 EIF1 PARPBP HDLBP	4.32e-06	156	168	9	gudmap_developingKidney_e15.5_ureter tip_flank cortic collct_500_k5
CoexpressionAtlas	dev gonad_e11.5_F_PrimGermCell_Oct_top-relative-expression-ranked_1000	CUL2 KNTC1 OFD1 TRIML2 POLA1 RPP38 JADE1 GTPBP10 UBR7 KIF20B CFAP20DC CD2 NANS CHEK2 HLTF AGK DCLK2 OSGIN2 RIMS2 ESPL1	5.49e-06	799	168	20	gudmap_dev gonad_e11.5_F_PrimGermCell_Oct_1000
CoexpressionAtlas	dev gonad_e12.5_F_GermCellOvary_Oct_top-relative-expression-ranked_1000	CUL2 KNTC1 OFD1 TRIML2 HSPA4L POLA1 RPP38 JADE1 TRAPPC8 UBR7 KIF20B CFAP20DC RBMX2 CHEK2 HLTF AGK DCLK2 RIMS2 ESPL1	2.89e-05	822	168	19	gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_1000
CoexpressionAtlas	dev gonad_e12.5_M_GermCellTestis_Oct_top-relative-expression-ranked_1000	CUL2 KNTC1 OFD1 TRIML2 HSPA4L POLA1 RPP38 JADE1 TRAPPC8 UBR7 KIF20B CFAP20DC NANS CHEK2 HLTF DCLK2 RIMS2 ESPL1	6.18e-05	795	168	18	gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_1000
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_1000	MED20 CUL2 KNTC1 OFD1 TRIML2 HSPA4L POLA1 TRAPPC8 CFAP20DC NETO2 RBMX2 CHEK2 DCLK2 SSH2 OSGIN2 PARPBP RIMS2 ESPL1	9.15e-05	820	168	18	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_1000
CoexpressionAtlas	gamma delta T cells, Tgd.vg2-24ahi.Th, TCRd+ Vg2- CD24+, Thymus, avg-2	KNTC1 POLA1 NR4A3 NR4A1 SMC2 KIF20B CD2 N4BP2 DCLK2 PARPBP ESPL1 IL7R	1.41e-04	422	168	12	GSM476658_500
CoexpressionAtlas	FacebaseRNAseq_e9.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#2	PDE6D ZNF280D ARSK FAM76B TRAPPC8 APOH GTPBP10 ZC3H11A CHEK2 TMPO MACF1 TNKS2 PARPBP PPP2R3C	1.64e-04	564	168	14	Facebase_RNAseq_e9.5_Mandibular Arch_2500_K2
CoexpressionAtlas	DevelopingKidney_e15.5_Cap mesenchyme_emap-27738_k-means-cluster#5_top-relative-expression-ranked_1000	SMC2 KIF20B IBTK UMOD TNKS2 EIF1 PARPBP	1.65e-04	146	168	7	gudmap_developingKidney_e15.5_Cap mesenchyme_1000_k5
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-COL13A1+_matrix_FBs\|Fibroblasts / Location, Cell class and cell subclass	ABR JKAMP NR4A1 CYP39A1 ABCA8 MAP3K4 ITPKC TMPO IL33	2.20e-08	169	173	9	84b898a9fd8ced67c6a501d5cef6416f519902c4
ToppCell	facs-Brain_Myeloid-Striatum-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WASHC4 CCDC80 ABCA9 RASGRP3 MACF1 TACC1 SSH2 PLEK TNKS2	5.76e-08	189	173	9	6dd4ec5ce4beb856f0d2d1654e3c4676d1d63736
ToppCell	facs-Brain_Myeloid-Striatum-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WASHC4 CCDC80 ABCA9 RASGRP3 MACF1 TACC1 SSH2 PLEK TNKS2	5.76e-08	189	173	9	875df61ee48baa5142ba4d2427bdec1c53e5a828
ToppCell	facs-Brain_Myeloid-Striatum-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WASHC4 CCDC80 ABCA9 RASGRP3 MACF1 TACC1 SSH2 PLEK TNKS2	5.76e-08	189	173	9	3ae479ec7e00c57127cbe51a398329b10ca9848c
ToppCell	facs-Brain_Myeloid-Striatum-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WASHC4 CCDC80 ABCA9 RASGRP3 MACF1 TACC1 SSH2 PLEK TNKS2	5.76e-08	189	173	9	97ef5215d841ff366a3e3682cd9bd04100cbfde0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 NR4A3 CCDC80 NR4A1 ABCA9 ABCA8 GREB1L KIAA1210 TACC1	6.89e-08	193	173	9	09a9ab029f01234459a88e3e994fe90ef4cbb8c6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 NR4A3 CCDC80 NR4A1 ABCA9 ABCA8 GREB1L KIAA1210	8.46e-07	191	173	8	2c51850f5c559d665b8a27a12b75af9ed58dffe1
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC80 ABCA9 RASGRP3 MACF1 TACC1 SSH2 TNKS2 IL7R	9.15e-07	193	173	8	9c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCell	facs-Brain_Myeloid-Hippocampus-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC80 ABCA9 RASGRP3 MACF1 TACC1 SSH2 TNKS2 IL7R	9.15e-07	193	173	8	a4f91bca5eaa985982d33a528f7566ffde154d47
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC80 ABCA9 RASGRP3 MACF1 TACC1 SSH2 TNKS2 IL7R	9.15e-07	193	173	8	b39d7feaac4ff8f7409cd3d15e8f3c6391367275
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC80 ABCA9 RASGRP3 MACF1 TACC1 SSH2 TNKS2 IL7R	9.15e-07	193	173	8	06b65110db974f4ef90d3511ff34428976a52c9c
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NPPC HSPA4L STK17A CYP26A1 NR4A1 SMC2 SNX31 IL33	9.15e-07	193	173	8	739fb2a57772a800a2e94bdd6c71285bb2c162a7
ToppCell	RV-02._Fibroblast_II\|RV / Chamber and Cluster_Paper	LAMA2 CCDC80 JADE1 ABCA9 ABCA8 TXNRD1 TACC1 SSH2	9.52e-07	194	173	8	11c79a8c56ece42713b04b321982e41e239f07a5
ToppCell	severe-CD4+_T_naive\|World / disease stage, cell group and cell class	HSPA4L RIMS3 ZNF208 PRDM5 GREB1L C7orf25 IL7R	2.76e-06	157	173	7	ccf9abe0b59e9ea728cec4bba1872ffe14c7385c
ToppCell	Influenza_Severe-cDC\|Influenza_Severe / Disease group and Cell class	NR4A3 LYSMD4 NR4A1 ARMCX1 C7orf25 ULBP1 DCLK2	3.99e-06	166	173	7	b40bdf0f7f381e25be61188e9f6c294d25a8b824
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KNTC1 SP100 SMC2 KIF20B IBTK PARPBP IL7R	3.99e-06	166	173	7	a41a20cef053c67da2d435e3e132ce28f1661c03
ToppCell	severe-CD4+_T_naive\|severe / disease stage, cell group and cell class	HSPA4L RIMS3 ZNF208 PRDM5 GREB1L C7orf25 IL7R	4.15e-06	167	173	7	02a8215fca59c357c1cdaa5738849eacf98c0bcc
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KNTC1 KIF20B CD2 TMPO PLEK PARPBP ESPL1	5.44e-06	174	173	7	7b318796728001c17b4043d2b033330c7be40c78
ToppCell	facs-Skin-Anagen-24m-Epithelial-keratinocyte_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KNTC1 KIF20B LIF CHEK2 ULBP1 PARPBP ESPL1	6.09e-06	177	173	7	e9d7682517fb30fd2ad535d59779d718a7024c13
ToppCell	facs-Skin-Anagen-24m-Epithelial-actively_dividing_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KNTC1 KIF20B LIF CHEK2 ULBP1 PARPBP ESPL1	6.09e-06	177	173	7	8a0f0fbb06cdacb99a3fdba0da3e0494b891db4f
ToppCell	COPD-Epithelial-Basal\|Epithelial / Disease state, Lineage and Cell class	NPPC STK17A CYP26A1 EDN1 SSH1 RCBTB1 IL33	6.32e-06	178	173	7	441d1dba720141891b11f404744c59834d80e6c5
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POLA1 CNTLN SMC2 KIF20B TMPO PARPBP ESPL1	6.55e-06	179	173	7	54191c00b29f53b520cd3243b5791daa4a2c72d7
ToppCell	COVID-19_Mild-Neu_4\|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients	KNTC1 CNTRL CD2 NANS TJP2 TMPO ESPL1	8.72e-06	187	173	7	714851e757c71c559ee6413a3f61d6c117c79ad2
ToppCell	Severe-B_activate-7\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	OFD1 CHMP1B STK17A EIF1B NR4A1 PARP14 TRIM22	9.67e-06	190	173	7	67e6c8a5a8724bdf2861fd76a711319dfc71d47a
ToppCell	COVID-19-kidney-Proliferating_T_cell\|COVID-19 / Disease (COVID-19 only), tissue and cell type	KNTC1 SMC2 KIF20B CD2 TMPO PARPBP ESPL1	1.00e-05	191	173	7	bae388e0e9447d576e68465d73d8313ef6925ffa
ToppCell	COPD-Endothelial-VE_Arterial\|Endothelial / Disease state, Lineage and Cell class	SORBS2 NR4A1 CLDN10 EDN1 ITPKC TACC1 IL33	1.00e-05	191	173	7	ef16ad1c1cd2c0c0377957398c98775b62a81754
ToppCell	Control-Endothelial-Endothelial-Gen_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FOXN3 TRIM22 EDN1 RASGRP3 IL33 IL7R L3MBTL4	1.07e-05	193	173	7	e1d546165dcc2392f540162206852c4717d7306f
ToppCell	LA-14._Fibroblast_III\|LA / Chamber and Cluster_Paper	LAMA2 NR4A3 NR4A1 ABCA9 LIF SLC9B2 TACC1	1.07e-05	193	173	7	7426c291bac59e539c427bcaae18abc7d397d44e
ToppCell	RV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	LAMA2 CCDC80 JADE1 ABCA9 ABCA8 TACC1 SSH2	1.14e-05	195	173	7	ce90b30dcdb56d4cd925cdb79fd9d7cefd998f48
ToppCell	ASK452-Epithelial-Type_1\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	STK17A UNC13D ABCA8 EDN1 SYT15 ITPKC OSGIN2	1.22e-05	197	173	7	dc0a6dca4af6b216357b06f67203274f8b2a8bb0
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Proliferating\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	CNTRL SMC2 KIF20B CHEK2 TMPO PARPBP ESPL1	1.26e-05	198	173	7	629d674a9c9108c1acb3f7af57bbdbf34bb0528e
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Proliferating-cycling_dorsal_progenitors\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	CNTRL SMC2 KIF20B CHEK2 TMPO PARPBP ESPL1	1.26e-05	198	173	7	5f0964c3aa7e1dc52cbb46e754078920b65bcb88
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_A\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CHMP1B STK17A NR4A3 NR4A1 LIF PLEK EIF1	1.26e-05	198	173	7	294a48ef6c0b89c7be948452cea79d23d3901e75
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	CCDC146 CNTRL RPP38 CLDN10 KIF20B ZC3H11A HDLBP	1.26e-05	198	173	7	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Dividing_Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KNTC1 SMC2 KIF20B CHEK2 TMPO PARPBP ESPL1	1.26e-05	198	173	7	f088badb90c6c2d916195f5649eda102119c9ac6
ToppCell	Non-neuronal-Dividing-IPC-IPC-div1\|World / Primary Cells by Cluster	CNTRL SMC2 KIF20B CHEK2 TMPO PARPBP ESPL1	1.31e-05	199	173	7	72823f26ecabcae1b514b7629cfce010c97b929a
ToppCell	COVID-19_Moderate\|World / disease group, cell group and cell class	SP100 STK17A PARP14 TRIM22 CD2 DDX24 IL7R	1.31e-05	199	173	7	952fac67588ad5676f5939e3c7f8bac803c27064
ToppCell	Non-neuronal-Dividing-IPC-IPC-div1-28\|World / Primary Cells by Cluster	CNTRL SMC2 KIF20B CHEK2 TMPO PARPBP ESPL1	1.31e-05	199	173	7	787688b68ae5d8768c0a24673ae07ab07616764a
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-FOXM1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	KNTC1 CNTRL SMC2 KIF20B TMPO PARPBP ESPL1	1.35e-05	200	173	7	4cfe08878a6981bf7b3567f9e82192d8f060ddde
ToppCell	Control_saline-Endothelial-Endothelial-FOXM1\|Control_saline / Treatment groups by lineage, cell group, cell type	KNTC1 CNTRL SMC2 KIF20B TMPO PARPBP ESPL1	1.35e-05	200	173	7	9bbc7b5561151f6ff65f40b3226271def732e5d9
ToppCell	Sigmoid-T_cell-cycling_gd_T\|T_cell / Region, Cell class and subclass	FMO5 POLA1 TRAPPC8 AFAP1L2 RASGRP3 PARPBP ESPL1	1.35e-05	200	173	7	4e489ecf472857357d45e9f6c7a812aa48b72ebf
ToppCell	VE\|World / Condition, Cell_class and T cell subcluster	SP100 STK17A PARP14 TRIM22 TMPO MACF1 IL7R	1.35e-05	200	173	7	8ae7cb81de3ffac5acdf3466d4b516d80cac95d3
ToppCell	normal_Lung-Endothelial_cells-Stalk-like_ECs\|Endothelial_cells / Location, Cell class and cell subclass	SORBS2 NR4A1 CLDN10 EDN1 AFAP1L2 TACC1 IL33	1.35e-05	200	173	7	413ac64bbe95b8c921c5396d8b5f298fec8c4f82
ToppCell	Sigmoid-(1)_T_cell-(18)_cycling_gd_T\|Sigmoid / shred on region, Cell_type, and subtype	FMO5 POLA1 TRAPPC8 KIF20B AFAP1L2 PARPBP ESPL1	1.35e-05	200	173	7	6e367abd1a4b87e20eb9095b8337723163e8bbae
ToppCell	Sigmoid-T_cell-cycling_gd_T\|Sigmoid / Region, Cell class and subclass	FMO5 POLA1 TRAPPC8 KIF20B AFAP1L2 PARPBP ESPL1	1.35e-05	200	173	7	9769185abae084ffac36420c749625e679b70ca8
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-Stem_cells-Neuroepithelial_cell\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	KNTC1 SMC2 KIF20B CHEK2 TMPO PARPBP ESPL1	1.35e-05	200	173	7	203b9a5de4430713da01b3331e69381db449a3a0
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-Stem_cells\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	KNTC1 SMC2 KIF20B CHEK2 TMPO PARPBP ESPL1	1.35e-05	200	173	7	a854e19703dc920e48304541e2b06ed013292f3e
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SPTBN5 KIAA1210 SLC13A4 APOBEC2 LRRC18	3.14e-05	93	173	5	af489f0dd76c3c1a84d164283149f550a7ece91c
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2-Endothelial_Tip.Dcn.Coch_(Coch)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SPTBN5 KIAA1210 SLC13A4 APOBEC2 LRRC18	3.14e-05	93	173	5	c1d0afcfa37c2dcbb12189b4ce56ae7c4bb7ba30
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2-Endothelial_Tip.Dcn.Coch_(Coch)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SPTBN5 KIAA1210 SLC13A4 APOBEC2 LRRC18	3.14e-05	93	173	5	0ea74c2820372d60d3804bf2c8bb0d03733dff98
ToppCell	Influenza_Severe-cDC\|World / Disease group and Cell class	NR4A3 NR4A1 ARMCX1 C7orf25 ULBP1 DCLK2	4.42e-05	164	173	6	c984228f73b9aa1aaf948541f64f41ed874770cd
ToppCell	normal_Pleural_Fluid-Myeloid_cells-mo-Mac\|Myeloid_cells / Location, Cell class and cell subclass	SOX11 ZNF607 LIF STC2 ULBP1 ATP6V0D2	4.73e-05	166	173	6	d16af6570806ed2880bd0efb5298932fd2a89cf5
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SORBS2 ZNF607 ABCA8 ANKRD13C RCBTB1 IFRD2	5.22e-05	169	173	6	c6e5b179461996ced6c7621dc01cec00d401f4e8
ToppCell	Lymphoid-Lymphoid-T_cells_(Cd8+_T_cell)\|Lymphoid / shred on cell class and cell subclass (v4)	CUL2 SPR LIF IBTK IL7R PLCE1	5.40e-05	170	173	6	20fd1a312c81c1bf3c5d2d6caf9b578e6b7a4171
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KNTC1 SOX11 ZFP57 SMC2 KIF20B ESPL1	5.76e-05	172	173	6	35c20de4db47dbf31c857d23c7a25cd7f95c085c
ToppCell	E18.5-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GALNTL6 KNTC1 INPPL1 CLDN10 STC2 SNX31	5.76e-05	172	173	6	1bbf5ed7d13635f9a7e528060341e0652699bd7c
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APOH ABCA9 MACF1 TACC1 SSH2 PLEK	5.95e-05	173	173	6	869da6a65d1b9b7529c666ec44e3c8ddec2ea408
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	EIF1B CNTRL PARP14 RASGRP3 PLEK ATP2B1	5.95e-05	173	173	6	d56e337eae727a29cd53cfd628e1b3c0a98e1f51
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APOH ABCA9 MACF1 TACC1 SSH2 PLEK	5.95e-05	173	173	6	0672bd8a4a9d18af343d01f09253fb3388896c10
ToppCell	facs-Brain_Myeloid-Cerebellum-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APOH ABCA9 MACF1 TACC1 SSH2 PLEK	5.95e-05	173	173	6	870e091ec30be01a900e1cb8b9ef1880e3b7b50d
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POLA1 SMC2 UBR7 RASGRP3 CHEK2 ULBP1	6.14e-05	174	173	6	66555c610251ea04f968c258e312d720c18e7cde
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRSAM1 NR4A1 EDN1 LIF SSH2 PLEK	6.34e-05	175	173	6	cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APOH ABCA9 MACF1 TACC1 SSH2 PLEK	6.34e-05	175	173	6	1ea6cf9da26601646f57fa14d558a5e9e1f0b345
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SMC2 KIF20B IGF2R APOBEC2 CHEK2 TMPO	6.34e-05	175	173	6	3e56695a9db97cb1d3503425c48eb79bbf99213e
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.5.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CHMP1B NR4A3 CD2 PLEK ESPL1 IL7R	6.54e-05	176	173	6	b99e20e4dd8b3322c9d7a08d518ed4f8f356b3de
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KNTC1 POLA1 CHEK2 TMPO PARPBP ESPL1	7.18e-05	179	173	6	88d44b04eb5c079531db663ed98ddb20b60feb9a
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CNTLN SMC2 KIF20B TMPO PARPBP ESPL1	7.41e-05	180	173	6	5e1680088065be14447d5d5465f91f7edd071a1e
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-Plasma_cell-B_c06-MKI67\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	PDE6D CNTLN SMC2 TXNRD1 AGK PARPBP	7.64e-05	181	173	6	c18e5a3f5d99043fa3cb33e2ac33fa98cd15d3db
ToppCell	P28-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KNTC1 SMC2 KIF20B TMPO PARPBP ESPL1	7.64e-05	181	173	6	e482fd116c00ff4d8db7be3c06b1bd1ffa2d479d
ToppCell	P28-Endothelial-proliferative_endothelial_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KNTC1 SMC2 KIF20B TMPO PARPBP ESPL1	7.64e-05	181	173	6	2be3d44619adb25d339e7a27b500a56e07e8de01
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARMCX1 EDN1 SYT15 AFAP1L2 NETO2 ATP2B1	8.11e-05	183	173	6	3427f3cbe6ea81709750e7dd3ff378f03ae65eab
ToppCell	E17.5-Epithelial-airway_epithelial_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	HSPA4L CLDN10 NEK5 TTC29 SNX31 LRRC18	8.11e-05	183	173	6	07cebb0e186e1bff14ac2a6bb6f8412d4aaa2350
ToppCell	E17.5-Epithelial-airway_epithelial_cell-club_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	HSPA4L CLDN10 NEK5 TTC29 SNX31 LRRC18	8.11e-05	183	173	6	e8e85e5be909f9cd85a6a041190bfcb855dfa1a4
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-4\|TCGA-Thryoid / Sample_Type by Project: Shred V9	ACO1 AXIN1 IGF2R TJP2 OSGIN2 RIMS2	8.36e-05	184	173	6	d9659d1e4465fec68f48a22edef443f354f6c7cf
ToppCell	CV-Healthy-7\|CV / Virus stimulation, Condition and Cluster	CHMP1B POLA1 NR4A3 RUFY3 NLRP6 TOP3A	8.36e-05	184	173	6	0e5cc77aaa73ceb791f8be7456177577fd2e5586
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4\|TCGA-Pancreas / Sample_Type by Project: Shred V9	LAMA2 CCDC80 MED13L ABCA9 ABCA8 EEA1	8.36e-05	184	173	6	67164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell	Control-T_cells-Cycling_NK/T_cells\|Control / group, cell type (main and fine annotations)	KNTC1 SMC2 KIF20B TMPO PARPBP ESPL1	8.61e-05	185	173	6	9766216b41ee62bbac4caa25cb98ec5627a24075
ToppCell	CV-Healthy-7\|Healthy / Virus stimulation, Condition and Cluster	CHMP1B POLA1 NR4A3 RUFY3 NLRP6 TOP3A	8.61e-05	185	173	6	1979d189c204f4c2893e3170a514ee7d5523406c
ToppCell	droplet-Lung-nan-3m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORBS2 CCDC80 ARMCX1 EDN1 SYT15 AFAP1L2	8.61e-05	185	173	6	eeb6f55a6f79adf80247baa2c4b0df44553557ad
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PARP14 TRIM22 SSH1 RASGRP3 IL7R L3MBTL4	9.14e-05	187	173	6	dffa8447c2f3fdacf39a7258c6b4e81a25245041
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	SORBS2 UNC13D GREB1L MYO18B L3MBTL4 PLCE1	9.41e-05	188	173	6	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 CCDC80 ABCA9 ABCA8 GREB1L KIAA1210	9.41e-05	188	173	6	ce85a56ac27a6432421dde93a1bafa8b943244b9
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LAMA2 CCDC80 AFAP1L2 IGF2R APOBEC2 PLCE1	9.41e-05	188	173	6	a906c29e3fda22eecfec3e5cac706c417bf2b7a4
ToppCell	RA-14._Fibroblast_III\|World / Chamber and Cluster_Paper	NR4A3 NR4A1 LIF ITPKC SLC9B2 TACC1	9.68e-05	189	173	6	b6e12d24d2b0735730bdc625f8318c1c9c2a9b3b
ToppCell	Control-Endothelial-Endothelial-FOXM1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KNTC1 SMC2 KIF20B TMPO PARPBP ESPL1	9.68e-05	189	173	6	1e1499b062d9c647c8f38b0c4e0d871d159be5dd
ToppCell	PND10-Epithelial-Epithelial_Airway\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CCDC146 HSPA4L CLDN10 ADGB NEK5 TTC29	9.68e-05	189	173	6	407d8a59969d83f014600aae1a55092283a13970
ToppCell	droplet-Spleen-nan-18m-Lymphocytic-immature_NKT_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	POLA1 SMC2 PRDM5 KIF20B PARPBP ESPL1	9.97e-05	190	173	6	b99271d139c8d01e20feb95d99f79c9b2756b4cb
ToppCell	E18.5-Epithelial-Epithelial_Airway\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CCDC146 HSPA4L CLDN10 NEK5 TTC29 SNX31	9.97e-05	190	173	6	5c012935ea5e35a2d0d08ea7dc04ffbe3c2a10ac
ToppCell	pdx-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	KNTC1 POLA1 KIF20B TMPO PARPBP ESPL1	9.97e-05	190	173	6	d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCell	Control-Endothelial-VE_Venous\|Endothelial / Disease state, Lineage and Cell class	SORBS2 EDN1 SYT15 ITPKC SSH1 IL33	9.97e-05	190	173	6	4e30155203b4a8c5e496fcbe9348b67b98ebc625
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LAMA2 CCDC80 AFAP1L2 IGF2R APOBEC2 PLCE1	9.97e-05	190	173	6	951e067d14412db67dc3babcdf61e41717d7b429
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CNTRL SMC2 KIF20B TMPO PARPBP ESPL1	9.97e-05	190	173	6	cd37ccd30c27cf65eda0a9165f35b7672f5acaf6
ToppCell	LV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	NPPC LAMA2 CCDC80 ABCA9 ABCA8 SSH2	1.03e-04	191	173	6	d36565257ccba8c1bbed2c1c01be66a9cbb5f834
ToppCell	PND07-Epithelial-Epithelial_Airway\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CCDC146 HSPA4L CLDN10 ADGB NEK5 TTC29	1.03e-04	191	173	6	b55500eb416f4f339031acad16b2737e5b891d8e
ToppCell	Dividing_Macrophages-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	SMC2 KIF20B NETO2 CHEK2 PARPBP ESPL1	1.03e-04	191	173	6	3e567ed6b5fefafa7f460e49d25d60bb52a0a6c8
ToppCell	IPF-Endothelial-VE_Arterial\|Endothelial / Disease state, Lineage and Cell class	ABR JADE1 NR4A1 CLDN10 EDN1 IL33	1.06e-04	192	173	6	e911e286da26202853f9650ba3cdefe5a5c9b585
ToppCell	367C-Myeloid-Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	CHMP1B NR4A3 NR4A1 PLEK EIF1 ATP2B1	1.06e-04	192	173	6	26326d7c3d907d754e85e128b7d8a52e90863f3f
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	SORBS2 MED13L RUFY3 MACF1 SSH2 L3MBTL4	1.06e-04	192	173	6	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	RV-01._Fibroblast_I\|RV / Chamber and Cluster_Paper	LAMA2 CCDC80 JADE1 ABCA9 ABCA8 TXNRD1	1.06e-04	192	173	6	356160b113c3305a61ceeaff33ce3c9da0be2878
ToppCell	human_hepatoblastoma-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	KNTC1 POLA1 KIF20B CHEK2 PARPBP ESPL1	1.09e-04	193	173	6	4b9fa2a4424f8abe63fa7bee78db93dda04ab15f
Drug	Succimer	SORBS2 ZNF280D POLA1 MFSD11 TRPC5 FAM76B JADE1 APOH SMC2 NDUFA10 TRIM22 KIF20B RUFY3 LIF NLN ZC3H11A STC2 N4BP2 RASGRP3 SLC9B2 TMPO ATP6V0D2 ABCC2 TNKS2 OSGIN2 RIMS2 ATP2B1	8.68e-07	1264	171	27	ctd:D004113
Disease	triglyceride measurement, very low density lipoprotein cholesterol measurement	TDRD15 ZNF280D CYP26A1 APOH IGF2R MACF1 TNKS2	2.89e-04	224	166	7	EFO_0004530, EFO_0008317
Disease	Kohlschutter-Tonz syndrome (implicated_via_orthology)	SLC13A4 SLC13A5	3.11e-04	5	166	2	DOID:0111668 (implicated_via_orthology)
Disease	very low density lipoprotein cholesterol measurement, phospholipid measurement	TDRD15 CYP26A1 APOH ABCA8 MAP3K4 IGF2R TNKS2	3.30e-04	229	166	7	EFO_0004639, EFO_0008317
Disease	Cartilage Diseases	NPPC EDN1	4.65e-04	6	166	2	C0007302
Disease	Chondromalacia	NPPC EDN1	4.65e-04	6	166	2	C0085700
Disease	Hypertensive disease	INPPL1 TRPC5 PTH EDN1 UMOD ATP2B1	7.45e-04	190	166	6	C0020538
Disease	mean arterial pressure, unipolar depression	SORBS2 TTC29 ATP2B1	7.69e-04	32	166	3	EFO_0003761, EFO_0006340
Disease	alcohol-related neurodevelopmental disorder (implicated_via_orthology)	SLC13A4 SLC13A5	8.61e-04	8	166	2	DOID:0050667 (implicated_via_orthology)
Disease	uterine fibroid	ZFP57 ZNF208 NLN CHEK2 MYO18B TOP3A	9.48e-04	199	166	6	EFO_0000731
Disease	HEPATOCELLULAR CARCINOMA	AXIN1 IGF2R	1.10e-03	9	166	2	114550
Disease	Hepatocellular carcinoma	AXIN1 IGF2R	1.10e-03	9	166	2	cv:C2239176
Disease	ascending aortic diameter	UNC13D MED13L EDN1 ATP2B1 PLCE1	1.20e-03	140	166	5	EFO_0021787
Disease	uremia (biomarker_via_orthology)	PTH EDN1	1.37e-03	10	166	2	DOID:4676 (biomarker_via_orthology)
Disease	Kidney Diseases	NR4A1 EDN1 UMOD IL33	1.56e-03	88	166	4	C0022658
Disease	very low density lipoprotein cholesterol measurement, lipid measurement	TDRD15 APOH ABCA8 MAP3K4 IGF2R TNKS2	1.58e-03	220	166	6	EFO_0004529, EFO_0008317
Disease	psychological resilience measurement	CNTLN DCLK2	2.00e-03	12	166	2	EFO_0009945
Disease	chronic kidney disease (implicated_via_orthology)	NR4A1 PTH	2.00e-03	12	166	2	DOID:784 (implicated_via_orthology)
Disease	Gastrointestinal Diseases	EDN1 ABCC2	2.00e-03	12	166	2	C0017178
Disease	Functional Gastrointestinal Disorders	EDN1 ABCC2	2.00e-03	12	166	2	C0559031
Disease	Cholera Infantum	EDN1 ABCC2	2.00e-03	12	166	2	C1565321
Disease	Malignant neoplasm of salivary gland	SOX11 NETO2 ESPL1	2.09e-03	45	166	3	C0220636
Disease	ovarian carcinoma	GALNTL6 SORBS2 SPINK9 CCDC80 FOXN3 ADGB N4BP2	2.35e-03	321	166	7	EFO_0001075
Disease	Salivary Gland Neoplasms	SOX11 NETO2 ESPL1	2.36e-03	47	166	3	C0036095
Disease	Rheumatoid Arthritis	NR4A3 CD2 TMPO ABCC2 PLEK	3.10e-03	174	166	5	C0003873
Disease	coronary artery disease	TDRD15 SORBS2 UNC13D KAT2A APOH ABCA8 EDN1 GLMN ZC3H11A AFAP1L2 IGF2R TTC29 DCLK2 ATP2B1 PLCE1	3.14e-03	1194	166	15	EFO_0001645
Disease	hypertension (is_marker_for)	NPPC PTH EDN1	3.33e-03	53	166	3	DOID:10763 (is_marker_for)
Disease	cholesteryl ester measurement	TDRD15 CYP26A1 APOH CYP39A1 ABCA8 IGF2R	3.43e-03	257	166	6	EFO_0010351
Disease	osteosarcoma (is_implicated_in)	PTH CHEK2	3.58e-03	16	166	2	DOID:3347 (is_implicated_in)
Disease	phenylalanine measurement	WASHC4 TXNRD1 PARPBP	3.70e-03	55	166	3	EFO_0005001
Disease	lipoprotein A measurement	TDRD15 APOH MAP3K4 IGF2R	3.75e-03	112	166	4	EFO_0006925
Disease	heart disease (biomarker_via_orthology)	NPPC EDN1	4.05e-03	17	166	2	DOID:114 (biomarker_via_orthology)
Disease	cholesterol to total lipids in chylomicrons and extremely large VLDL percentage	TDRD15 APOH	4.05e-03	17	166	2	EFO_0022232
Disease	triglycerides in IDL measurement	TDRD15 IGF2R TNKS2	4.30e-03	58	166	3	EFO_0022149
Disease	hypertension (is_implicated_in)	NPPC INPPL1 EDN1 RASGRP3	4.93e-03	121	166	4	DOID:10763 (is_implicated_in)
Disease	event free survival time, urinary bladder cancer	ARHGAP17 LRRC31	5.05e-03	19	166	2	EFO_0000482, MONDO_0001187
Disease	blood arsenic measurement	SORBS2 ZNF280D	5.05e-03	19	166	2	EFO_0021527
Disease	free androgen index	CYP26A1 FOXN3 APOH ABCA8 CHEK2 TNKS2 RIMS2	5.41e-03	374	166	7	EFO_0007005
Disease	cerebellum white matter volume change measurement, age at assessment	ABCA8 TJP2	5.59e-03	20	166	2	EFO_0008007, EFO_0021498
Disease	Adenocarcinoma of prostate	AXIN1 CHEK2	5.59e-03	20	166	2	C0007112

Protein segments in the cluster

Peptide	Gene	Start	Entry
VLEGFKKNEEALKKC	TACC1	701	O75410
SCDSNIGADKVEKKK	ZNF280D	826	Q6N043
DVLLCAKLKKTSAGK	ABR	326	Q12979
KKDFESCLGAKQGFK	ACO1	386	P21399
KNCTGRFTKKEIKNI	ARSK	261	Q6UWY0
KKQKGVFHICALKDN	DCAF17	311	Q5H9S7
KKATVFLNPAACKGK	AGK	61	Q53H12
RSVKDAAKKGQKDVC	CHMP3	46	Q9Y3E7
AAKKGQKDVCIVLAK	CHMP3	51	Q9Y3E7
VAAKDSDFQCLSKKK	CNTRL	1526	Q7Z7A1
LHGDKVSFFCKNKEK	APOH	291	P02749
TKVKFKAAKKNCSVG	CNTLN	826	Q9NXG0
NFKDKGKLSAALKDL	ADGB	806	Q8N7X0
NGKLKCAGSSLFLKK	ABCA9	691	Q8IUA7
SAKFKCTAGNKVSKE	CD2	181	P06729
KDVKKKCSAGLKLSN	AFAP1L2	321	Q8N4X5
LGRELVCKESKKTFK	ANKRD13C	436	Q8N6S4
QASKACVVKREFKKA	APPBP2	251	Q92624
KAFKKKFACNGTVIE	EIF1B	61	O60739
ANKKGLSKGCFGLKL	NPPC	101	P23582
DKVVGNKRLKEATCK	CHEK2	311	O96017
ENKAAALACKKLKSL	DHX30	301	Q7L2E3
KAKAKIACLAGIVFI	CLDN10	111	P78369
KIGNKEACKVLAKQL	CHMP2B	51	Q9UQN3
IAKAVACHNFVKAKK	FAM204A	186	Q9H8W3
KGASEIILKKCFKIL	ATP2B1	601	P20020
EIQAALKKLKEAGCK	APOBEC2	161	Q9Y235
KIRQKGFVQKCKASG	CCDC80	271	Q76M96
LKEFIAKASKCGAFK	RCBTB1	516	Q8NDN9
NLVRDKKTGKSKGFC	RBMX2	66	Q9Y388
GIKKADGTCNTNFKK	ITPKC	556	Q96DU7
KKLEKLGVFSACKAN	KAT2A	101	Q92830
CQKLKFFKDTEIAKI	OFD1	216	O75665
RLYGKLAKVAKSNKC	PARPBP	546	Q9NWS1
LAKVAKSNKCTAKDK	PARPBP	551	Q9NWS1
KSNKCTAKDKLISGQ	PARPBP	556	Q9NWS1
ADSCGKRLKSKDALK	PRDM5	266	Q9NQX1
KVAAEKKGKVQVFFC	NOX5	726	Q96PH1
GCKGFFKRTVQKNAK	NR4A1	286	P22736
ENFLKVGEKAGAKCK	PPP2R3C	121	Q969Q6
LKFAAKELSRSAKKC	CHMP1B	11	Q7LBR1
CKFFKDSRNIKILKD	NXF3	391	Q9H4D5
KAKSEGKLAKQICKV	NSUN3	6	Q9H649
EIKRKCSLNKTGKFA	PRAMEF17	211	Q5VTA0
IFTANKKCKQGTEKD	MED13L	726	Q71F56
SKDAVKKKACTLAQF	MAGEB6	191	Q8N7X4
KLALQYGCKVADIKK	LYSMD4	86	Q5XG99
FKKKDKGGINLTATC	DRG1	181	Q9Y295
KDCKINLASKNKLAS	TMPO	656	P42166
QCKVSFGNKRKLLKV	NLRP8	576	Q86W28
FGAFATCKVLQKKVL	LRSAM1	46	Q6UWE0
EKLCASELFKGKKAS	MYO1A	846	Q9UBC5
KLKLSQKKCSFLCDV	IBTK	756	Q9P2D0
FFCSKVKKTDGTLKF	SPINK9	66	Q5DT21
DTSGKDVFQKKKLGC	LIF	171	P15018
DVFQKKKLGCQLLGK	LIF	176	P15018
TGKEFALKIIDKAKC	DCLK2	416	Q8N568
KAFKKKFACNGTVIE	EIF1	61	P41567
LNLLKKQKVISFAGC	OR4K17	86	Q8NGC6
KKILKCKAVSRELNF	PDE6D	51	O43924
KKGVKFEINLDKCIS	NEK5	576	Q6P3R8
CRHGKKLVKDVKAFA	PNPLA4	26	P41247
TNGKNLKKEVGKILC	NRG2	216	O14511
EHFLQKLGKKAVNKC	LRRC31	76	Q6UY01
GKCINVLKNSEKSKF	KIF20B	411	Q96Q89
KVARNCIKITFDGKK	LRRC18	16	Q8N456
LLKQVAALSKGKKFD	FAM76B	316	Q5HYJ3
KDGNIKTALKKCSDL	KNTC1	1076	P50748
HAKCFKKEQIDGKAF	L3MBTL4	561	Q8NA19
GLLKEDAKGCLQKSF	LAMA2	1961	P24043
TKKFLLIGKSNICVK	IL7R	96	P16871
SALLAKKGEFAKNLK	ABCC2	846	Q92887
TKAVDAFKKSFKLCV	MFSD11	221	O43934
DLKKFKFLKGATLCV	GREB1L	1861	Q9C091
IGCLQKLLFGKVAKD	NOC2L	216	Q9Y3T9
CAGKKTADKAVDLSK	POLA1	141	P09884
KVCNNSKKGLKFTVS	ERCC8	286	Q13216
AKKSREISLKEFGCK	MACF1	2841	Q9UPN3
ICTGKGKLAKEIAEK	NDUFA10	66	O95299
KASFKKLLKACVPGC	SBF1	1361	O95248
LDNGVCIAKKKTKVA	RIMS2	1301	Q9UQ26
IKENFQFKKDGHCLK	PARP14	941	Q460N5
KCVLQSVSGLKKIFK	OSGIN2	391	Q9Y236
QKGKAAILDLEKTCK	EEA1	881	Q15075
DFSKVLKQCRLAKGL	CHCHD2P9	136	Q5T1J5
VESLKKLGKQAQGCK	ESPL1	511	Q14674
ASKALCFKLGKSQQK	IL33	21	O95760
CFKLGKSQQKAKEVC	IL33	26	O95760
KISALKGSKGKDCEI	GTPBP10	76	A4D1E9
CTVNKLLGKKCINKS	GFRAL	91	Q6UXV0
LLGKKCINKSDNVKE	GFRAL	96	Q6UXV0
AKLCSKLKAELKFLQ	C7orf25	36	Q9BPX7
KICGQSLANKYLEKK	FMO5	246	P49326
LSLNKCFKKVDKERS	FOXN3	166	O00409
CFKKVDKERSQSIGK	FOXN3	171	O00409
GKVGVACKRNAKKAE	AXIN1	596	O15169
ACKRNAKKAESGKSA	AXIN1	601	O15169
LAKYCDNLLKKSAKG	CUL2	391	Q13617
KCLQLNVKKGSFVAK	DPY19L4	331	Q7Z388
LTLADALEKCLKKGK	IFRD2	181	Q12894
KQSSCGKFQTKGIKV	DDX24	11	Q9GZR7
EAGDEGKKKCKFKAL	KIAA1210	156	Q9ULL0
SCVGKEFAKILLKIF	CYP26A1	441	O43174
FEKNIPDIKACKSAK	CYP39A1	226	Q9NYL5
LSIVNVCKAGKKKKN	EXOC1	21	Q9NV70
LKKGACAVEGSKKTD	HLTF	456	Q14527
ATGKLYACKKLNKKR	GRK1	211	Q15835
KDCSKLGKKCIYQQL	EDN1	146	P05305
LGCNFKETCSLSKKK	SLC13A4	336	Q9UKG4
GCGLESKKNEKAALK	SLC13A5	286	Q86YT5
SCRLVAAQEKKKKSL	NLRP6	676	P59044
CLRNKEFKDALKKAL	OR6B2	291	Q6IFH4
VKLKGFFQSAKASKI	MED20	96	Q9H944
LIKLGDFGCSVKLKN	MAP3K4	1476	Q9Y6R4
GCKGFFKRTVQKNAK	NR4A3	311	Q92570
SAQKELRKQLKCKDF	GALNTL6	416	Q49A17
NEKLKDELLKFCFKS	GLMN	201	Q92990
RTTAACKKDIFKANK	IGF2R	156	P11717
CLKHGLKAKKTFLGQ	RUFY3	111	Q7L099
KCGKLKAPAAAGAKA	SOX11	166	P35716
NKFVKCKKTSAVLGS	SYT15	326	Q9BQS2
VIGLKCVLALAFKKN	RPP38	171	P78345
EKGLECLAKSKNTLK	TDRD15	1576	B5MCY1
EANACKIQLIKKKGK	GFPT1	51	Q06210
RIKKADNSACNKGKV	PLCE1	1626	Q9P212
AGASKLKKLKAALDC	ARHGAP17	291	Q68EM7
KVYLLENGACLAKKK	RIMS3	196	Q9UJD0
IKKAIKCIEGGQKFA	PLEK	96	P08567
KKVSKKGKACLLFDH	RASGRP3	136	Q8IV61
GLDSKALKKLKGVCV	SLC9B2	191	Q86UD5
LKDFLSGIQKKALKA	INPPL1	271	O15357
ACKARLKKAKAAEAK	SH3GLB2	171	Q9NR46
ACNEKLGKSVVAKVK	NANS	286	Q9NR45
CKEKKKAGVFEQITK	NETO2	331	Q8NC67
CDLIKGDLKDKSFKQ	JADE1	666	Q6IE81
QKIKATVFDDCKKEG	STXBP3	16	O00186
KQTEKAKCKASVFEA	SORBS2	716	O94875
FLSRKSKIKIAKDDC	SNX31	416	Q8N9S9
SQKKVAKLQKACEAL	SPTBN5	2776	Q9NRC6
KFAVVRKCIKKDSGK	STK17A	71	Q9UEE5
RKCIKKDSGKEFAAK	STK17A	76	Q9UEE5
SGLCEKDVKKKLEFG	SSH1	561	Q8WYL5
LADRKVFLSQGKLKC	ABCA8	681	O94911
KTQGCKQDTLLLAKK	CCDC146	791	Q8IYE0
SANCKLRKIFTLKSK	CFAP20DC	36	Q6ZVT6
FKESGVCVKKIKALA	ARMCX1	421	Q9P291
FILNLKKKECKDRGF	NLN	336	Q9BYT8
GFAAALKCGLTKKQL	TXNRD1	601	Q16881
KKCGEGTLALLKNAK	TRIML2	196	Q8N7C3
SRKLFDQANKLKKTC	TJP2	836	Q9UDY2
ACKGDKTKEAVSILK	ZFP57	436	Q9NU63
KVSLGKCQLKSLGFD	UMOD	341	P07911
KFISKAKKHGSKCLV	SSH2	376	Q76I76
LVCAFNKGKLKVLAT	HSPA4L	211	O95757
DAQGKSFIKDALKCK	STC2	96	O76061
KAKGKLVDCKVSAQK	SPR	226	P35270
CAAQTLEKRGKAKPK	ZC3H11A	636	O75152
FKQGTSKKCIQSEDK	SP100	621	P23497
NKCGKSFRLKAGLKV	ZNF607	256	Q96SK3
LKDAQKKLDCAKTKA	SMC2	791	O95347
DAAKKGCLARVKKLS	TNKS2	651	Q9H2K2
DLKLICDGKKDKFVV	TOP3A	591	Q13472
ACKGFLSRQEFKKLK	MYO18B	1346	Q8IUG5
KECGKAFSKFSILTK	ZNF208	836	O43345
CFKIAQLIKIDCGKK	TTC29	166	Q8NA56
CKEKLNKKNKIGAAF	WASHC4	1031	Q2M389
CKLLPDKAKVNSGNK	UBR7	111	Q8N806
ESKSGCKLQELKAKQ	UBR7	281	Q8N806
TKLASREKGKFCFKA	TRAPPC8	1146	Q9Y2L5
CVNHKAKAFASLGKK	ULBP1	66	Q9BZM6
AKAFASLGKKVNVTK	ULBP1	71	Q9BZM6
RAKSKSVSFNLGCKK	TRPC5	791	Q9UL62
CGKAFKKSLDLNVHK	ZNF355P	296	Q9NSJ1
KVTLKGAKDCVEAAK	HDLBP	846	Q00341
AICFLTKSDGKSVKK	PTH	16	P01270
GKKLQIFCKEDGKVI	TRIM22	101	Q8IYM9
FCLKATVKQAKGILG	UNC13D	111	Q70J99
NKHKIRDTGKKSFKC	ZNF506	161	Q5JVG8
EKCGKLFNKKSHLLV	ZNF814	831	B7Z6K7
LDCGKSFSKKPQLKV	ZNF175	646	Q9Y473
VAIKCVAKKSLNKAS	ULK3	41	Q6PHR2
ALQKKSVKEILGKCH	ATP6V0D2	116	Q8N8Y2
VKKIACGLGKSDRFK	JKAMP	176	Q9P055
FEKDCATKLKEKQLF	N4BP2	1516	Q86UW6