Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmethyl-CpG binding

MBD3L5 MBD3L3 MBD3L4 MBD3L2 MBD3L2B

1.48e-0931335GO:0008327
GeneOntologyBiologicalProcessDNA methylation-dependent constitutive heterochromatin formation

MBD3L5 MBD3L3 MBD3L4 MBD3L2 MBD3L2B

6.74e-0944325GO:0006346
GeneOntologyBiologicalProcessfacultative heterochromatin formation

MBD3L5 MBD3L3 MBD3L4 MBD3L2 MBD3L2B

2.13e-0855325GO:0140718
GeneOntologyBiologicalProcessheterochromatin formation

MBD3L5 MBD3L3 MBD3L4 MBD3L2 MBD3L2B

4.91e-06163325GO:0031507
GeneOntologyBiologicalProcessepigenetic regulation of gene expression

MBD3L5 MBD3L3 MBD3L4 MBD3L2 ZNF335 MBD3L2B

1.02e-05330326GO:0040029
GeneOntologyBiologicalProcessnegative regulation of gene expression, epigenetic

MBD3L5 MBD3L3 MBD3L4 MBD3L2 MBD3L2B

1.43e-05203325GO:0045814
GeneOntologyBiologicalProcessnegative regulation of transcription by RNA polymerase II

MBD3L5 KLF11 KLF17 MBD3L3 MBD3L4 KLF10 MBD3L2 PRDM2 MBD3L2B

2.20e-051053329GO:0000122
GeneOntologyBiologicalProcessnegative regulation of DNA-templated transcription

MBD3L5 KLF11 KLF17 MBD3L3 MBD3L4 ZNF397 KLF10 MBD3L2 PRDM2 MBD3L2B

3.24e-0513993210GO:0045892
GeneOntologyBiologicalProcessnegative regulation of RNA biosynthetic process

MBD3L5 KLF11 KLF17 MBD3L3 MBD3L4 ZNF397 KLF10 MBD3L2 PRDM2 MBD3L2B

3.53e-0514133210GO:1902679
GeneOntologyBiologicalProcesschromatin organization

MBD3L5 MBD3L3 MBD3L4 MBD3L2 ZNF335 TP53BP1 PRDM2 MBD3L2B

5.10e-05896328GO:0006325
GeneOntologyBiologicalProcessprotein-DNA complex organization

MBD3L5 MBD3L3 MBD3L4 MBD3L2 ZNF335 TP53BP1 PRDM2 MBD3L2B

1.09e-04999328GO:0071824
GeneOntologyBiologicalProcesschromatin remodeling

MBD3L5 MBD3L3 MBD3L4 MBD3L2 ZNF335 PRDM2 MBD3L2B

1.15e-04741327GO:0006338
GeneOntologyBiologicalProcessmembrane repolarization during ventricular cardiac muscle cell action potential

KCNQ1 RNF207

3.13e-0417322GO:0098915
GeneOntologyBiologicalProcessregulation of delayed rectifier potassium channel activity

KCNQ1 RNF207

4.81e-0421322GO:1902259
GeneOntologyBiologicalProcessregulation of ventricular cardiac muscle cell membrane repolarization

KCNQ1 RNF207

6.84e-0425322GO:0060307
GeneOntologyBiologicalProcessmembrane repolarization during cardiac muscle cell action potential

KCNQ1 RNF207

7.99e-0427322GO:0086013
GeneOntologyBiologicalProcessregulation of neurotransmitter secretion

CACNA1E MYOF RIMS1

8.02e-04118323GO:0046928
DomainMeCpG-bd_2/3_C_dom

MBD3L5 MBD3L3 MBD3L4 MBD3L2

2.17e-107314IPR025884
DomainMBD2/MBD3_p55-bd

MBD3L5 MBD3L3 MBD3L4 MBD3L2

2.17e-107314IPR032343
DomainMBD_C

MBD3L5 MBD3L3 MBD3L4 MBD3L2

2.17e-107314PF14048
DomainMBDa

MBD3L5 MBD3L3 MBD3L4 MBD3L2

2.17e-107314PF16564
Domain-

ZNF771 KLF11 KLF17 ZNF397 KLF10 ZNF335 PRDM2

9.98e-056793173.30.160.60
Domainzf-C2H2

ZNF771 KLF11 KLF17 ZNF397 KLF10 ZNF335 PRDM2

1.13e-04693317PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF771 KLF11 KLF17 ZNF397 KLF10 ZNF335 PRDM2

1.14e-04694317IPR013087
DomainZINC_FINGER_C2H2_2

ZNF771 KLF11 KLF17 ZNF397 KLF10 ZNF335 PRDM2

2.26e-04775317PS50157
DomainZINC_FINGER_C2H2_1

ZNF771 KLF11 KLF17 ZNF397 KLF10 ZNF335 PRDM2

2.30e-04777317PS00028
DomainZnf_C2H2-like

ZNF771 KLF11 KLF17 ZNF397 KLF10 ZNF335 PRDM2

2.67e-04796317IPR015880
DomainZnf_C2H2

ZNF771 KLF11 KLF17 ZNF397 KLF10 ZNF335 PRDM2

2.86e-04805317IPR007087
DomainZnF_C2H2

ZNF771 KLF11 KLF17 ZNF397 KLF10 ZNF335 PRDM2

2.92e-04808317SM00355
DomainIon_trans_dom

KCNQ1 CACNA1E

1.53e-02114312IPR005821
DomainIon_trans

KCNQ1 CACNA1E

1.53e-02114312PF00520
Pubmed

Haploid male germ cell- and oocyte-specific Mbd3l1 and Mbd3l2 genes are dispensable for early development, fertility, and zygotic DNA demethylation in the mouse.

MBD3L5 MBD3L3 MBD3L4 MBD3L2 MBD3L2B

3.36e-15633518942147
Pubmed

MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor.

MBD3L5 MBD3L3 MBD3L4 MBD3L2 MBD3L2B

3.36e-15633512504854
Pubmed

MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.

MBD3L5 MBD3L3 MBD3L4 MBD3L2 MBD3L2B

1.67e-121533515701600
Pubmed

The DNA sequence and biology of human chromosome 19.

PHLDB3 MBD3L5 CACTIN MBD3L3 MBD3L4 RPL18A

2.59e-0728433615057824
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

MYOF CACTIN RIMS1 FHOD1 ZNF335 TP53BP1 PRDM2 EIF3CL

4.92e-0777433815302935
Pubmed

Dynamic transcriptional changes of TIEG1 and TIEG2 during mouse tissue development.

KLF11 KLF10

8.73e-07233220201061
Pubmed

Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth.

KLF11 KLF10

8.73e-0723329748269
Pubmed

Sclerostin antibody treatment rescues the osteopenic bone phenotype of TGFβ inducible early gene-1 knockout female mice.

KLF11 KLF10

2.62e-06333231975377
Pubmed

Host immunity and KLF 11 deficiency together promote fibrosis in a mouse model of endometriosis.

KLF11 KLF10

2.62e-06333237321514
Pubmed

KLF10 Mediated Epigenetic Dysregulation of Epithelial CD40/CD154 Promotes Endometriosis.

KLF11 KLF10

5.23e-06433227488034
Pubmed

Rebuilding essential active zone functions within a synapse.

CACNA1E RIMS1

1.83e-05733235176221
Pubmed

A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A.

KLF11 KLF10

2.44e-05833211438660
Pubmed

Common variants at ten loci modulate the QT interval duration in the QTSCD Study.

KCNQ1 RNF207

4.78e-051133219305409
Pubmed

Klf5 regulates muscle differentiation by directly targeting muscle-specific genes in cooperation with MyoD in mice.

KLF11 KLF10

9.10e-051533227743478
Pubmed

Purification and Transcriptomic Analysis of Mouse Fetal Leydig Cells Reveals Candidate Genes for Specification of Gonadal Steroidogenic Cells.

ADAMTS16 TRANK1

1.48e-041933225855264
Pubmed

Common variants at ten loci influence QT interval duration in the QTGEN Study.

KCNQ1 RNF207

2.58e-042533219305408
Pubmed

Mammalian SP/KLF transcription factors: bring in the family.

KLF11 KLF10

2.58e-042533215820306
Pubmed

Lem2 is essential for cardiac development by maintaining nuclear integrity.

KCNQ1 RNF207

4.25e-043233237067297
Cytoband19p13.2

MBD3L5 MBD3L3 MBD3L4 MBD3L2 MBD3L2B

6.26e-0722933519p13.2
CytobandEnsembl 112 genes in cytogenetic band chr19p13

MBD3L5 CACTIN MBD3L3 MBD3L4 MBD3L2 MBD3L2B RPL18A

1.33e-06797337chr19p13
GeneFamilyZinc fingers C2H2-type|Kruppel like factors

KLF11 KLF17 KLF10

1.09e-0618213624
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF771 KLF11 KLF17 ZNF397 KLF10 ZNF335

1.25e-0471821628
ToppCellfacs-Marrow-B-cells-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS16 KCNQ1 RIMS1 TRANK1

3.14e-061373344dcb15de821439011df1bb0bbd7682d674bd725d
ToppCellfacs-Marrow-B-cells-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS16 KCNQ1 RIMS1 TRANK1

3.14e-06137334c05ceeb7b483324604cb3f647d2da2b3786071b1
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PITPNM2 CACNA1E TRANK1 RNF207

1.05e-051863347278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Th_Sst|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADAMTS16 KCNQ1 MYOF

1.52e-0565333c336aa3501b9576bf12ef1bbefae55fff7705662
DiseaseT wave morphology measurement

KCNQ1 RNF207

9.02e-0514302EFO_0008398
Diseasevery low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio

PITPNM2 ZNF335 TP53BP1

1.47e-03222303EFO_0008317, EFO_0020943
DiseaseHypertrophic Cardiomyopathy

KCNQ1 KLF10

1.54e-0357302C0007194
Diseasecholesterol to total lipids in medium VLDL percentage

ZNF335 TP53BP1

1.88e-0363302EFO_0022239
Diseasetriglycerides to total lipids in medium VLDL percentage

ZNF335 TP53BP1

1.88e-0363302EFO_0022335
DiseaseManic Disorder

RIMS1 TRANK1

2.38e-0371302C0024713
Diseasevery low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

PITPNM2 ZNF335 TP53BP1

2.40e-03264303EFO_0008317, EFO_0020944
DiseaseManic

RIMS1 TRANK1

2.86e-0378302C0338831
DiseaseDepression, Bipolar

RIMS1 TRANK1

2.93e-0379302C0005587
Diseaselongitudinal BMI measurement

CACNA1E MBD3L2B

3.16e-0382302EFO_0005937
Diseaseblood cobalt measurement

KCNQ1 DCAF8L1

4.74e-03101302EFO_0007577
Diseasesexual dimorphism measurement

PITPNM2 KCNQ1 TRANK1 ZNF335 TP53BP1

4.79e-031106305EFO_0021796
Diseasehypertension (implicated_via_orthology)

ADAMTS16 KCNQ1

7.50e-03128302DOID:10763 (implicated_via_orthology)
DiseaseGlobal developmental delay

CACNA1E ZNF335

8.08e-03133302C0557874
DiseaseVertigo

RIMS1 PRDM2

8.79e-03139302HP_0002321

Protein segments in the cluster

PeptideGeneStartEntry
AKLQRRHHERMERRY

USH1G

151

Q495M9
RHHERMERRYRRELA

USH1G

156

Q495M9
HHISRRLLERVNMCR

CCL28

36

Q9NRJ3
PRSSHLRERRRRHHM

CACNA1E

761

Q15878
LRERRRRHHMSVWEQ

CACNA1E

766

Q15878
SHEIMHHQRRRRAVP

ADAMTS16

76

Q8TE57
MAQHRRGALQHRIRV

PHLDB3

271

Q6NSJ2
LREHHRATIKVIRRM

KCNQ1

506

P51787
REIHMAKAHRRRAAR

MBD3L5

31

A6NJ08
REIHMAKAHRRRAAR

MBD3L2B

31

A0A1B0GVZ6
RMGSHAHPLRRSRRE

PIMREG

166

Q9BSJ6
IHDTGLRRVMVRAHR

PITPNM2

211

Q9BZ72
REIHMAKAHRRRAAR

MBD3L3

31

A6NE82
RMHARVSRARHERRH

RIMS1

376

Q86UR5
SHVHRRDFRERMLEI

RIMS1

816

Q86UR5
ARRRMISKQFHHQLR

EIF3CL

706

B5ME19
RRFMRSDHLTKHARR

KLF10

436

Q13118
RRFMRSDHLTKHARR

KLF11

461

O14901
RSDELRRHMRVHTRY

KLF17

326

Q5JT82
AHMARARLRERHQDV

CACTIN

446

Q8WUQ7
RLSAHHHRMRRKAAV

C2orf81

326

A6NN90
RMLRFFVRHLLQRAH

DCAF8L1

546

A6NGE4
AMLRIVHRRVCNRFH

FHOD1

941

Q9Y613
RNRRSHRAMRVAHLE

FMR1NB

11

Q8N0W7
REIHMAKAHRRRAAR

MBD3L4

31

A6NDZ8
TNMRRHQRRVHERHL

PRDM2

496

Q13029
REIHMAKAHRRRAAR

MBD3L2

31

Q8NHZ7
RCRDETHRARMFARH

RNF207

126

Q6ZRF8
RDMGARHRARAHSIQ

RPL18A

111

Q02543
RRYMRQHLDHVRRRL

L3HYPDH

51

Q96EM0
SSHFIRHRRAHMRRR

ZNF771

271

Q7L3S4
LHRHMRTIREVRTLV

TP53BP1

1236

Q12888
KAFRHRSVLMRHQRV

ZNF397

516

Q8NF99
MENRRRSRQDSAAHL

TRANK1

606

O15050
LRHMRERHFRPVAAA

ZNF335

261

Q9H4Z2
AEKMYHTHRRRRLVR

MYOF

1011

Q9NZM1