Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	RNF150 RNF148 UBR4 TRIM54 UBR3 PJA1 RNF114 RNF115 RBCK1	1.14e-04	473	80	9	GO:0004842
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	RNF150 RNF148 UBR4 TRIM54 UBR3 PJA1 RNF114 RNF115	1.21e-04	372	80	8	GO:0061630
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	RNF150 RNF148 UBR4 TRIM54 UBR3 PJA1 RNF114 RNF115	1.92e-04	398	80	8	GO:0061659
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	RNF150 RNF148 UBR4 TRIM54 UBR3 PJA1 RNF114 RNF115 RBCK1	2.06e-04	512	80	9	GO:0019787
GeneOntologyMolecularFunction	aminoacyltransferase activity	RNF150 RNF148 UBR4 TRIM54 UBR3 PJA1 RNF114 RNF115 RBCK1	2.73e-04	532	80	9	GO:0016755
GeneOntologyMolecularFunction	scaffold protein binding	PSAP BRAF CHRFAM7A CHRNA7	5.32e-04	93	80	4	GO:0097110
GeneOntologyBiologicalProcess	positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure	CHRFAM7A CHRNA7	1.45e-05	2	79	2	GO:0001988
GeneOntologyBiologicalProcess	baroreceptor response to decreased systemic arterial blood pressure	CHRFAM7A CHRNA7	4.33e-05	3	79	2	GO:0001982
GeneOntologyBiologicalProcess	generation of ovulation cycle rhythm	CHRFAM7A CHRNA7	8.65e-05	4	79	2	GO:0060112
GeneOntologyBiologicalProcess	ubiquitin-dependent protein catabolic process via the N-end rule pathway	UBR4 UBR3	8.65e-05	4	79	2	GO:0071596
GeneOntologyCellularComponent	spine apparatus membrane	CHRFAM7A CHRNA7	4.33e-05	3	80	2	GO:0098897
GeneOntologyCellularComponent	apical part of cell	CACNB3 RAPGEF3 USH2A CHRFAM7A SLC4A5 CHRNA7 NOTCH1 CRB1 SLC5A1	4.27e-04	592	80	9	GO:0045177
GeneOntologyCellularComponent	spine apparatus	CHRFAM7A CHRNA7	5.12e-04	9	80	2	GO:0097444
GeneOntologyCellularComponent	apical plasma membrane	CACNB3 USH2A CHRFAM7A SLC4A5 CHRNA7 NOTCH1 CRB1 SLC5A1	5.47e-04	487	80	8	GO:0016324
MousePheno	airway basal cell hyperplasia	CHRFAM7A CHRNA7	1.94e-05	2	62	2	MP:0011115
MousePheno	abnormal airway basal cell differentiation	CHRFAM7A CHRNA7	1.94e-05	2	62	2	MP:0011114
MousePheno	abnormal airway basal cell morphology	CHRFAM7A CHRNA7	1.94e-05	2	62	2	MP:0011113
MousePheno	abnormal nicotine-mediated receptor currents	CHRFAM7A CHRNA7	1.15e-04	4	62	2	MP:0009475
Domain	ZF_RING_1	RNF150 KMT2D RNF148 TRIM54 UBR3 PJA1 RNF114 RNF115 RBCK1	4.67e-06	291	81	9	PS00518
Domain	zf-C3HC4	RNF150 RNF148 TRIM54 UBR3 PJA1 RNF114 RNF115 RBCK1	5.54e-06	223	81	8	PF00097
Domain	ZF_RING_2	RNF150 KMT2D RNF148 TRIM54 UBR3 PJA1 RNF114 RNF115 RBCK1	5.67e-06	298	81	9	PS50089
Domain	Znf_C3HC4_RING-type	RNF150 RNF148 TRIM54 PJA1 RNF114 RNF115 RBCK1	9.75e-06	172	81	7	IPR018957
Domain	Znf_RING	RNF150 KMT2D RNF148 TRIM54 UBR3 PJA1 RNF114 RNF115 RBCK1	1.17e-05	326	81	9	IPR001841
Domain	EGF_1	ZAN PAMR1 BTC SLIT1 TENM1 USH2A NOTCH1 CRB1	1.47e-05	255	81	8	PS00022
Domain	EGF	ZAN PAMR1 BTC SLIT1 NOTCH1 CRB1	1.80e-05	126	81	6	PF00008
Domain	-	AP1B1 AP2B1	1.86e-05	2	81	2	2.60.40.1150
Domain	Clathrin_b-adaptin_app_Ig-like	AP1B1 AP2B1	1.86e-05	2	81	2	IPR013037
Domain	EGF_2	ZAN PAMR1 BTC SLIT1 TENM1 NOTCH1 CRB1 EPHA3	1.94e-05	265	81	8	PS01186
Domain	-	RNF150 KMT2D RNF148 TRIM54 UBR3 PJA1 RNF114 ZFYVE1 RNF115 RBCK1	2.38e-05	449	81	10	3.30.40.10
Domain	Znf_RING/FYVE/PHD	RNF150 KMT2D RNF148 TRIM54 UBR3 PJA1 RNF114 ZFYVE1 RNF115 RBCK1	2.88e-05	459	81	10	IPR013083
Domain	RING	RNF150 KMT2D RNF148 TRIM54 PJA1 RNF114 RNF115 RBCK1	5.28e-05	305	81	8	SM00184
Domain	AP_complex_bsu_1_2_4	AP1B1 AP2B1	5.56e-05	3	81	2	IPR016342
Domain	B2-adapt-app_C	AP1B1 AP2B1	5.56e-05	3	81	2	PF09066
Domain	-	COL16A1 SLIT1 CLSTN2 USH2A CRB1	5.78e-05	95	81	5	2.60.120.200
Domain	EGF_3	ZAN PAMR1 BTC SLIT1 TENM1 NOTCH1 CRB1	7.20e-05	235	81	7	PS50026
Domain	EGF	ZAN PAMR1 BTC SLIT1 TENM1 NOTCH1 CRB1	7.20e-05	235	81	7	SM00181
Domain	zf-RING_2	RNF150 RNF148 PJA1 RNF115	7.59e-05	52	81	4	PF13639
Domain	EGF-like_dom	ZAN PAMR1 BTC SLIT1 TENM1 NOTCH1 CRB1	1.03e-04	249	81	7	IPR000742
Domain	B-adaptin_app_sub_C	AP1B1 AP2B1	1.11e-04	4	81	2	IPR015151
Domain	B2-adapt-app_C	AP1B1 AP2B1	1.11e-04	4	81	2	SM01020
Domain	Laminin_G	COL16A1 SLIT1 USH2A CRB1	1.17e-04	58	81	4	IPR001791
Domain	EGF-like_CS	ZAN PAMR1 BTC SLIT1 TENM1 NOTCH1 CRB1	1.38e-04	261	81	7	IPR013032
Domain	AP_beta	AP1B1 AP2B1	1.84e-04	5	81	2	IPR026739
Domain	hEGF	SLIT1 NOTCH1 CRB1	2.38e-04	28	81	3	PF12661
Domain	Beta2_adaptin/TBP_C_dom	AP1B1 AP2B1	2.76e-04	6	81	2	IPR012295
Domain	-	AP1B1 AP2B1	2.76e-04	6	81	2	3.30.310.10
Domain	ConA-like_dom	COL16A1 ZAN SLIT1 CLSTN2 USH2A CRB1	3.79e-04	219	81	6	IPR013320
Domain	ZF_UBR	UBR4 UBR3	3.85e-04	7	81	2	PS51157
Domain	zf-UBR	UBR4 UBR3	3.85e-04	7	81	2	PF02207
Domain	Znf_UBR	UBR4 UBR3	3.85e-04	7	81	2	IPR003126
Domain	ZnF_UBR1	UBR4 UBR3	3.85e-04	7	81	2	SM00396
Domain	Znf-RING_LisH	TRIM54 RNF114 RBCK1	4.27e-04	34	81	3	IPR027370
Domain	zf-RING_UBOX	TRIM54 RNF114 RBCK1	4.27e-04	34	81	3	PF13445
Domain	Man6P_isomerase_rcpt-bd_dom	ELAPOR2 IGF2R	5.11e-04	8	81	2	IPR009011
Domain	Coatomer/calthrin_app_sub_C	AP1B1 AP2B1	5.11e-04	8	81	2	IPR009028
Domain	Growth_fac_rcpt_	ELAPOR2 SLIT1 NOTCH1 CRB1 EPHA3	5.86e-04	156	81	5	IPR009030
Domain	LAM_G_DOMAIN	SLIT1 USH2A CRB1	5.94e-04	38	81	3	PS50025
Domain	Clathrin_a/b/g-adaptin_app_Ig	AP1B1 AP2B1	6.56e-04	9	81	2	IPR008152
Domain	Alpha_adaptinC2	AP1B1 AP2B1	6.56e-04	9	81	2	PF02883
Domain	Alpha_adaptinC2	AP1B1 AP2B1	6.56e-04	9	81	2	SM00809
Domain	Laminin_G_2	SLIT1 USH2A CRB1	6.92e-04	40	81	3	PF02210
Domain	fn3	MYLK CSF2RB USH2A EPHA3 MYBPC1	6.95e-04	162	81	5	PF00041
Domain	LamG	SLIT1 USH2A CRB1	9.16e-04	44	81	3	SM00282
Domain	TIL	VWF ZAN	1.19e-03	12	81	2	PF01826
Domain	Coatomer/clathrin_app_Ig-like	AP1B1 AP2B1	1.19e-03	12	81	2	IPR013041
Domain	C8	VWF ZAN	1.19e-03	12	81	2	PF08742
Domain	FN3	MYLK CSF2RB USH2A EPHA3 MYBPC1	1.26e-03	185	81	5	SM00060
Domain	Unchr_dom_Cys-rich	VWF ZAN	1.40e-03	13	81	2	IPR014853
Domain	C8	VWF ZAN	1.40e-03	13	81	2	SM00832
Domain	TIL_dom	VWF ZAN	1.63e-03	14	81	2	IPR002919
Domain	FN3	MYLK CSF2RB USH2A EPHA3 MYBPC1	1.74e-03	199	81	5	PS50853
Domain	Clathrin/coatomer_adapt-like_N	AP1B1 AP2B1	1.88e-03	15	81	2	IPR002553
Domain	Adaptin_N	AP1B1 AP2B1	1.88e-03	15	81	2	PF01602
Domain	EGF_CA	PAMR1 SLIT1 NOTCH1 CRB1	1.96e-03	122	81	4	SM00179
Domain	EGF-like_Ca-bd_dom	PAMR1 SLIT1 NOTCH1 CRB1	2.08e-03	124	81	4	IPR001881
Domain	Post-SET_dom	SETDB1 KMT2D	2.14e-03	16	81	2	IPR003616
Domain	VWD	VWF ZAN	2.14e-03	16	81	2	SM00216
Domain	PostSET	SETDB1 KMT2D	2.14e-03	16	81	2	SM00508
Domain	VWF_type-D	VWF ZAN	2.14e-03	16	81	2	IPR001846
Domain	VWFD	VWF ZAN	2.14e-03	16	81	2	PS51233
Domain	POST_SET	SETDB1 KMT2D	2.14e-03	16	81	2	PS50868
Domain	VWD	VWF ZAN	2.14e-03	16	81	2	PF00094
Domain	FN3_dom	MYLK CSF2RB USH2A EPHA3 MYBPC1	2.15e-03	209	81	5	IPR003961
Domain	CTCK_1	VWF SLIT1	2.72e-03	18	81	2	PS01185
Domain	VWC_out	VWF ZAN	3.03e-03	19	81	2	SM00215
Domain	PA	RNF150 RNF148	3.03e-03	19	81	2	PF02225
Domain	PA_domain	RNF150 RNF148	3.03e-03	19	81	2	IPR003137
Domain	CT	VWF SLIT1	4.06e-03	22	81	2	SM00041
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	RNF150 UBR4 UBR3 RNF114 RBCK1	2.97e-06	95	81	5	29643511
Pubmed	Enhancing cognitive function in chronic TBI: The Role of α7 nicotinic acetylcholine receptor modulation.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	38070724
Pubmed	Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	34453977
Pubmed	Inhibition of pancreatic acinar mitochondrial thiamin pyrophosphate uptake by the cigarette smoke component 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	26999808
Pubmed	Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	27129924
Pubmed	Sensorimotor gating and spatial learning in α7-nicotinic receptor knockout mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	23521765
Pubmed	Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	28258105
Pubmed	The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	19344760
Pubmed	Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine Receptors.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	29114104
Pubmed	Autophagy is Involved in Neuroprotective Effect of Alpha7 Nicotinic Acetylcholine Receptor on Ischemic Stroke.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	33995108
Pubmed	E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	32552811
Pubmed	Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	24836856
Pubmed	Studies of sperm from mutant mice suggesting that two neurotransmitter receptors are important to the zona pellucida-initiated acrosome reaction.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	15948184
Pubmed	Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	35678315
Pubmed	Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	12628457
Pubmed	Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	25157794
Pubmed	Mesenchymal Stem Cells or Interleukin-6 Improve Episodic Memory of Mice Lacking α7 Nicotinic Acetylcholine Receptors.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	31202708
Pubmed	Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	22246862
Pubmed	Activation of Nicotinic Acetylcholine Receptors Decreases Apoptosis in Human and Female Murine Pancreatic Islets.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	27471776
Pubmed	Targeting α-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	22688057
Pubmed	Different Effects of Nicotine and N-Stearoyl-ethanolamine on Episodic Memory and Brain Mitochondria of α7 Nicotinic Acetylcholine Receptor Knockout Mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	32028688
Pubmed	Activation of α7 Nicotinic Acetylcholine Receptor Ameliorates Zymosan-Induced Acute Kidney Injury in BALB/c Mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	30429582
Pubmed	A transgenic mouse model reveals fast nicotinic transmission in hippocampal pyramidal neurons.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	21501254
Pubmed	Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	21368056
Pubmed	Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	1400473
Pubmed	Activation of Alpha 7 Cholinergic Nicotinic Receptors Reduce Blood-Brain Barrier Permeability following Experimental Traumatic Brain Injury.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	26937017
Pubmed	Diminished α7 nicotinic acetylcholine receptor (α7nAChR) rescues amyloid-β induced atrial remodeling by oxi-CaMKII/MAPK/AP-1 axis-mediated mitochondrial oxidative stress.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	36603528
Pubmed	Activation of α7nAChR Promotes Diabetic Wound Healing by Suppressing AGE-Induced TNF-α Production.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	26650489
Pubmed	Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	22848433
Pubmed	Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	16650968
Pubmed	Microglial cell response in α7 nicotinic acetylcholine receptor-deficient mice after systemic infection with Escherichia coli.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	35413868
Pubmed	Long-term improvements in sensory inhibition with gestational choline supplementation linked to α7 nicotinic receptors through studies in Chrna7 null mutation mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	24462939
Pubmed	Probing the putative α7 nAChR/NMDAR complex in human and murine cortex and hippocampus: Different degrees of complex formation in healthy and Alzheimer brain tissue.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	29261717
Pubmed	Altered hippocampal circuit function in C3H alpha7 null mutant heterozygous mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	18199426
Pubmed	Stroke-induced activation of the α7 nicotinic receptor increases Pseudomonas aeruginosa lung injury.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	22490926
Pubmed	Dendritic spine alterations in the hippocampus and parietal cortex of alpha7 nicotinic acetylcholine receptor knockout mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	23270857
Pubmed	Neuronal nicotinic alpha7 receptors modulate inflammatory cytokine production in the skin following ultraviolet radiation.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	18077004
Pubmed	Smoking in adult attention-deficit/hyperactivity disorder: interaction between 15q13 nicotinic genes and Temperament Character Inventory scores.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	19462340
Pubmed	Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	16923147
Pubmed	NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha 7 subunit of a neuronal nicotinic acetylcholine receptor.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	11790782
Pubmed	Genetic deletion of α7 nAChRs reduces hippocampal granule and pyramidal cell number in both sexes but impairs pattern separation in males only.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	37746145
Pubmed	A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	19631623
Pubmed	Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	15770102
Pubmed	Cortical synaptic NMDA receptor deficits in α7 nicotinic acetylcholine receptor gene deletion models: implications for neuropsychiatric diseases.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	24326163
Pubmed	Functional role of alpha7 nicotinic receptor in chronic neuropathic and inflammatory pain: studies in transgenic mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	23811428
Pubmed	Alpha 7 subunit of nAChR regulates migration of human mesenchymal stem cells.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	20720594
Pubmed	Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	17019565
Pubmed	Dilinoleoylphosphatidylcholine ameliorates scopolamine-induced impairment of spatial learning and memory by targeting alpha7 nicotinic ACh receptors.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	19100751
Pubmed	Activation of the α7 Nicotinic Acetylcholine Receptor Prevents against Microglial-Induced Inflammation and Insulin Resistance in Hypothalamic Neuronal Cells.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	35883638
Pubmed	Chrna7 genotype is linked with alpha7 nicotinic receptor expression but not alpha7 RNA levels.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	19368846
Pubmed	Alpha7-nicotinic acetylcholine receptors mediate an Abeta(1-42)-induced increase in the level of acetylcholinesterase in primary cortical neurones.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	15009674
Pubmed	Hydroxynorketamine, but not ketamine, acts via α7 nicotinic acetylcholine receptor to control presynaptic function and gene expression.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	38253622
Pubmed	The role of dorsal root ganglia alpha-7 nicotinic acetylcholine receptor in complete Freund's adjuvant-induced chronic inflammatory pain.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	34514543
Pubmed	α7 nicotinic acetylcholine receptor (α7nAChR) expression in bone marrow-derived non-T cells is required for the inflammatory reflex.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	22183893
Pubmed	Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	9364063
Pubmed	Evidence suggesting that the mouse sperm acrosome reaction initiated by the zona pellucida involves an alpha7 nicotinic acetylcholine receptor.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	12606407
Pubmed	Genetic variations in CHRNA7 or CHRFAM7 and susceptibility to dementia.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	22300029
Pubmed	GTS-21 ameliorates polymicrobial sepsis-induced hepatic injury by modulating autophagy through α7nAchRs in mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	32018068
Pubmed	CHRNA7 and CHRFAM7A mRNAs: co-localized and their expression levels altered in the postmortem dorsolateral prefrontal cortex in major psychiatric disorders.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	26206074
Pubmed	Nicotine elicits prolonged calcium signaling along ventral hippocampal axons.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	24349346
Pubmed	The role of nicotinic acetylcholine receptor (nAChR) α7 subtype in the functional interaction between nicotine and ethanol in mouse cerebellum.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	21143250
Pubmed	Cholinergic modulation of appetite-related synapses in mouse lateral hypothalamic slice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	16319313
Pubmed	Impaired synaptic plasticity in the visual cortex of mice lacking α7-nicotinic receptor subunit.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	25797465
Pubmed	Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	29197398
Pubmed	Cholinergic signaling via the α7 nicotinic acetylcholine receptor regulates the migration of monocyte-derived macrophages during acute inflammation.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	38178134
Pubmed	In hippocampal oriens interneurons anti-Hebbian long-term potentiation requires cholinergic signaling via α7 nicotinic acetylcholine receptors.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	23325242
Pubmed	Glutamatergic synapse formation is promoted by α7-containing nicotinic acetylcholine receptors.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	22649244
Pubmed	Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	17898229
Pubmed	Alpha7-nicotinic receptors modulate nicotine-induced reinforcement and extracellular dopamine outflow in the mesolimbic system in mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	21901321
Pubmed	Dopamine release in prefrontal cortex in response to beta-amyloid activation of alpha7 * nicotinic receptors.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	17935702
Pubmed	Neuronal nicotinic alpha7 receptors modulate early neutrophil infiltration to sites of skin inflammation.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	20624304
Pubmed	Cytokine-induced alterations of α7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	21784975
Pubmed	Lack of acetylcholine nicotine alpha 7 receptor suppresses development of collagen-induced arthritis and adaptive immunity.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	20659128
Pubmed	Stimulation of α7 nicotinic acetylcholine receptor by nicotine increases suppressive capacity of naturally occurring CD4+CD25+ regulatory T cells in mice in vitro.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	20843956
Pubmed	Mice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birth.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	10800961
Pubmed	Characterization of allelic variants at chromosome 15q14 in schizophrenia.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	16417613
Pubmed	Absence of alpha7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	11834293
Pubmed	Reduced Chrna7 expression in mice is associated with decreases in hippocampal markers of inhibitory function: implications for neuropsychiatric diseases.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	22314319
Pubmed	Antagonism of Cerebral High Mobility Group Box 1 Ameliorates Dendritic Cell Dysfunction in Sepsis.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	34512319
Pubmed	Visual acuity is reduced in alpha 7 nicotinic receptor knockout mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	22281823
Pubmed	Activation of α7-nAChRs Promotes the Clearance of α-Synuclein and Protects Against Apoptotic Cell Death Induced by Exogenous α-Synuclein Fibrils.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	33718373
Pubmed	Nicotinic receptor involvement in regulation of functions of mouse neutrophils from inflammatory site.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	26965141
Pubmed	A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	27676657
Pubmed	Central role of alpha7 nicotinic receptor in differentiation of the stratified squamous epithelium.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	12391028
Pubmed	Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	25365546
Pubmed	α7 Nicotinic Acetylcholine Receptor Regulates the Function and Viability of L Cells.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	29992246
Pubmed	Mouse muscle denervation increases expression of an alpha7 nicotinic receptor with unusual pharmacology.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	12562921
Pubmed	CHRFAM7A expression in mice increases resiliency after injury.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	34792616
Pubmed	An ovarian phenotype of alpha 7 nicotinic receptor knockout mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	37432973
Pubmed	Altered baroreflex responses in alpha7 deficient mice.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	10942027
Pubmed	Stimulation of toll-like receptor 4 downregulates the expression of α7 nicotinic acetylcholine receptors via histone deacetylase in rodent microglia.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	32413437
Pubmed	Astrocytic α7 Nicotinic Receptor Activation Inhibits Amyloid-β Aggregation by Upregulating Endogenous αB-crystallin through the PI3K/Akt Signaling Pathway.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	30345917
Pubmed	Alpha7 nicotinic acetylcholine receptor expression in Alzheimer's disease: receptor densities in brain regions of the APP(SWE) mouse model and in human peripheral blood lymphocytes.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	17192639
Pubmed	Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	17431097
Pubmed	Activation of α7 Nicotinic Acetylcholine Receptor Protects Against 1-Methyl-4-Phenylpyridinium-Induced Astroglial Apoptosis.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	31780901
Pubmed	Short-Term High-Fat Diet Consumption Reduces Hypothalamic Expression of the Nicotinic Acetylcholine Receptor α7 Subunit (α7nAChR) and Affects the Anti-inflammatory Response in a Mouse Model of Sepsis.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	30967878
Pubmed	The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	25497451
Pubmed	Macrophage α7nAChR alleviates the inflammation of neonatal necrotizing enterocolitis through mTOR/NLRP3/IL-1β pathway.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	38996778
Pubmed	Nicotine improves sustained attention in mice: evidence for involvement of the alpha7 nicotinic acetylcholine receptor.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	14970827
Pubmed	The effect of crebanine on memory and cognition impairment via the alpha-7 nicotinic acetylcholine receptor.	CHRFAM7A CHRNA7	5.36e-06	2	81	2	22749860
GeneFamily	Ring finger proteins	RNF150 RNF148 TRIM54 PJA1 RNF114 RNF115 RBCK1	2.70e-05	275	58	7	58
GeneFamily	Fibronectin type III domain containing	MYLK CSF2RB USH2A EPHA3 MYBPC1	1.60e-04	160	58	5	555
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR4 UBR3	2.10e-04	7	58	2	785
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF462 HINFP ZNF627 ZNF138 ZNF473 ZNF607 ZNF510 ZNF404	1.97e-03	718	58	8	28
CoexpressionAtlas	JC_iEC_top-relative-expression-ranked_2500_k-means-cluster#3	PSAP RAPGEF3 KCNJ12 SCN7A TRIM54 MAEL SLC5A1 MYBPC1	1.86e-05	311	78	8	JC_iEC_2500_K3
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL16A1 MYLK PAMR1 SCN7A CLSTN2 EPHA3	1.39e-06	192	81	6	c5f8e766453f87847b740d6988c524b3d0ef3765
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL16A1 PAMR1 KCND2 SCN7A CLSTN2 EPHA3	1.76e-06	200	81	6	74e74123ea7bf38d337a3a0248a6a51437c6ab42
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Kcne4\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RAPGEF3 SCN7A CLSTN2 EPHA3 MYBPC1	9.74e-06	156	81	5	896e2d958be0a5c62fb6eebad2dfb7e1ce69f3ad
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	GREB1L KCND2 THSD7B USH2A EPHA3	1.07e-05	159	81	5	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	facs-Heart-RA-18m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GREB1L IGF2R VWF CPD NOTCH1	1.39e-05	168	81	5	06dc5b2d356d3a9454b10bba6f3b9ead2a0a7d46
ToppCell	facs-Heart-RA-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GREB1L IGF2R VWF CPD NOTCH1	1.39e-05	168	81	5	1002f058a340763e3d8de0bd1f0547a903526ec6
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	BTC TRIM54 CLSTN2 EPHA3 MYBPC1	1.60e-05	173	81	5	5aa4d45a01d2d09eff8b4deb32bd91ab2471210a
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_D\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	RAPGEF3 KCNJ12 SCN7A NOTCH1 CFAP65	1.65e-05	174	81	5	b4f3f5334803e5903bc496decf923f2e44f7fa3c
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	BTC TRIM54 CLSTN2 EPHA3 MYBPC1	1.65e-05	174	81	5	2947e5906b172d149412fa4e77476fce4ea695d2
ToppCell	facs-Trachea-24m-Epithelial-glandular_epithelial\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GREB1L ELAPOR2 DHX32 CLSTN2 SLC4A5	2.16e-05	184	81	5	61caaa31975e05c9a6512079c791fed5a9e2d39f
ToppCell	facs-Trachea-24m-Epithelial-glandular_epithelial-lung_secretory_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GREB1L ELAPOR2 DHX32 CLSTN2 SLC4A5	2.16e-05	184	81	5	03da0f0f89f1ca5a3ccca1e22972f3129464e68e
ToppCell	facs-Trachea-24m-Epithelial-glandular_epithelial-lung_secretory_cell-mucous\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GREB1L ELAPOR2 DHX32 CLSTN2 SLC4A5	2.16e-05	184	81	5	9ed2a65a4ca0ebbbb89ace61027522f93369843d
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PAMR1 SCN7A TENM1 THSD7B MYBPC1	2.16e-05	184	81	5	7d41784eac0935e77d6bc701f20c693adf998730
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL16A1 SCN7A THSD7B CHRFAM7A CHRNA7	2.21e-05	185	81	5	4c42bd3cd72f91f4d4ebb849069a03761a2cd662
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL16A1 SCN7A THSD7B CHRFAM7A CHRNA7	2.27e-05	186	81	5	fef543f188edb0d1704d9c6ace366a0f8017bf53
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GREB1L COL16A1 SCN7A CHRFAM7A CHRNA7	2.33e-05	187	81	5	d2ffb2f34f07b0dd5d3cb3ee0275f46ebecf4146
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL16A1 PAMR1 SCN7A CLSTN2 EPHA3	2.71e-05	193	81	5	9ab47b360bee1d4f1092c2269e58acebe9584021
ToppCell	Control-Fibroblasts-Intermediate_pathological_FB\|Control / group, cell type (main and fine annotations)	COL16A1 MYLK KCND2 SCN7A EPHA3	2.78e-05	194	81	5	03a269f75a481ea54aea8e6444605db8d6df493d
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	COL16A1 MYLK PAMR1 KCND2 SCN7A	2.78e-05	194	81	5	5f5f0cdeacd5e1b28717d78dabdb9eb95f661e36
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	COL16A1 MYLK PAMR1 SCN7A EPHA3	2.78e-05	194	81	5	99577a5a631e607b5abe7a1b0d8d6a5eabe50196
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	COL16A1 MYLK PAMR1 SCN7A EPHA3	2.85e-05	195	81	5	70387a62f121f8c374dba1aca9ab65cfed6a0b10
ToppCell	ASK428-Mesenchymal\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	COL16A1 MYLK PAMR1 SCN7A EPHA3	2.85e-05	195	81	5	2b156163975d9a3d3fda1402acd9831d0fdc9e25
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL16A1 MYLK PAMR1 SCN7A EPHA3	2.85e-05	195	81	5	1236dc60288c7dd91868e86e9174a2dacd3b11b3
ToppCell	ASK428-Mesenchymal-Fibroblast\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	COL16A1 MYLK PAMR1 SCN7A EPHA3	2.85e-05	195	81	5	c269c0d894a0f55da6495b59d4b9abb9f68df684
ToppCell	droplet-Heart-nan-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GREB1L IGF2R VWF CPD NOTCH1	2.92e-05	196	81	5	e386526332138e636aef2542c11316347a45689c
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RNF150 MYLK BTC MAEL EPHA3	2.92e-05	196	81	5	9830fb3da7a60f65ad463e9054bb77c06b025e4d
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RNF150 COL16A1 MYLK SCN7A TENM1	2.99e-05	197	81	5	44673c38384453207871d3fd8e8ba9093cc06bc5
ToppCell	distal-3-mesenchymal-Fibromyocyte\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL16A1 MYLK PAMR1 MAEL THSD7B	3.07e-05	198	81	5	dc93886439a378a0c71e99acb8081bfb6b6d467b
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	COL16A1 MYLK PAMR1 SCN7A EPHA3	3.07e-05	198	81	5	300d7cc56207d77168390fa1ffcbcf76767b1b80
ToppCell	distal-mesenchymal-Fibromyocyte-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL16A1 MYLK PAMR1 MAEL THSD7B	3.07e-05	198	81	5	9d1d95e7703cfc70a8ad427e400c340dbd205db8
ToppCell	background-Hepatic_Stellate_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	RNF150 COL16A1 PAMR1 SCN7A EPHA3	3.07e-05	198	81	5	bd11b0e9e80449aab979a02c1023e0638c431c7c
ToppCell	distal-mesenchymal-Fibromyocyte\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL16A1 MYLK PAMR1 MAEL THSD7B	3.07e-05	198	81	5	fbfac1d10e4224990a094cc84b74bbc206881423
ToppCell	Bronchial-10x5prime-Stromal-Fibroblastic-Fibro_immune_recruiting\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	RNF150 MYLK SCN7A CLSTN2 EPHA3	3.14e-05	199	81	5	0cdbedf09ec72734b86ddab3fec562e066afed92
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-TSPAN12-L1-2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	COL16A1 SCN7A THSD7B CHRFAM7A CHRNA7	3.22e-05	200	81	5	523d799eb315b33b77e02d5b7db63dad8450c4e1
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-LGR5--L5-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PAMR1 SCN7A TENM1 THSD7B MYBPC1	3.22e-05	200	81	5	8c1d4fffa5abe89ee2ff84fed2dfa97c779bde04
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-LGR5-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PAMR1 SCN7A TENM1 THSD7B MYBPC1	3.22e-05	200	81	5	1026b4ede4ea61d01ea942164b37a08c8c8234ff
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-TSPAN12\|Neuronal / cells hierarchy compared to all cells using T-Statistic	COL16A1 SCN7A THSD7B CHRFAM7A CHRNA7	3.22e-05	200	81	5	e5cef95e563a6e793ade190ce88c999bfa0af460
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	COL16A1 SCN7A THSD7B CHRFAM7A CHRNA7	3.22e-05	200	81	5	8a8f9d9e5ffab3f736c4bd0a5bb616d442d137d1
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-LGR5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PAMR1 SCN7A TENM1 THSD7B MYBPC1	3.22e-05	200	81	5	72c9cd872074b60f62685a95eab83c41e609eb6e
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Stem_cells-neuroepithelial-like_cells\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	TENM1 CLSTN2 CRB1 TMEM81	8.51e-05	127	81	4	9071cd0953c8bb6746dc9cd13d153e3d6ef40b08
ToppCell	MS-CD4-CD4_Treg\|MS / Condition, Cell_class and T cell subcluster	ZNF462 RTKN2 TENM1 SLC4A5	1.28e-04	141	81	4	df257dd4dcc45c1ace57340798e150a6e932531d
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Htr2c\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RAPGEF3 CLSTN2 EPHA3 MYBPC1	1.46e-04	146	81	4	47368f981180ca6a8c81a50f7f9430f12456f609
ToppCell	Children_(3_yrs)-Mesenchymal-myofibroblast_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL16A1 MYLK SCN7A STAG3	1.70e-04	152	81	4	621e9b33cd3bb1c7b7d0633069f286b203e3d9c0
ToppCell	NS-critical-LOC-Myeloid-Basophil\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MROH8 COL16A1 RAPGEF3 ZNF404	2.07e-04	160	81	4	8a4746463ca1976f7d6de803496c851249ced797
ToppCell	Adult-Mesenchymal-airway_smooth_muscle_cell-D231\|Adult / Lineage, Cell type, age group and donor	COL16A1 MYLK THSD7B EPHA3	2.07e-04	160	81	4	d783d29150033e9181c0e30870070268fed3fd85
ToppCell	PND07-Immune-Immune_Myeloid-DC-maDC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNB3 CSF2RB ZNF473 TXNDC17	2.07e-04	160	81	4	7db30647b596f0c419087e6fabb9b99dcd5bddd4
ToppCell	PND07-Immune-Immune_Myeloid-DC-maDC-maDC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNB3 CSF2RB ZNF473 TXNDC17	2.07e-04	160	81	4	01f22cdb2a2f73776b7f91746e95c1850df94235
ToppCell	Adult-Mesenchymal-myofibroblast_cell-D175\|Adult / Lineage, Cell type, age group and donor	GREB1L TENM1 STAG3 EPHA3	2.12e-04	161	81	4	048b7dc00746987a24bf870d4d278c4183eb04a2
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BTC SLC4A5 CRB1 SLC5A1	2.12e-04	161	81	4	c4970501c038ed36de447da70eabff020ad78713
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Kcne4\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RAPGEF3 SCN7A CLSTN2 MYBPC1	2.12e-04	161	81	4	be77e99faf653480c166305df3a4e93db76f0dcb
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-Secretory\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BTC SLC4A5 CRB1 SLC5A1	2.12e-04	161	81	4	41a89a3d99a9bd6039a3d881d1d9dcd18bc07f25
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Kctd12\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ZAN ZNF473 MAEL	2.16e-04	64	81	3	2edc3ae3e334bb04a411778e3b102b3a84a97824
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Kctd12-Inhibitory_Gad1Gad2Slc17a8_Htr3a.Ktcd12_(Interneuron,__GABA/Glutamate_co-releasing?_(candidate_CGE-derived_9))-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ZAN ZNF473 MAEL	2.16e-04	64	81	3	b8aac6e83c2e5b09b55ea22ddb29940099f186e1
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Kctd12-Inhibitory_Gad1Gad2Slc17a8_Htr3a.Ktcd12_(Interneuron,__GABA/Glutamate_co-releasing?_(candidate_CGE-derived_9))\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ZAN ZNF473 MAEL	2.16e-04	64	81	3	3e3eed30abcecd3fc8d30489dca05222ac353180
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ELAPOR2 ZAN TENM1 USH2A	2.17e-04	162	81	4	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SCN7A THSD7B CHRFAM7A CHRNA7	2.28e-04	164	81	4	ed7e0c8ccad7d19b9cc72d70391936ff5e698f28
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Htr2c\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	RAPGEF3 SCN7A CLSTN2 MYBPC1	2.33e-04	165	81	4	c6b23013d77fa9aa967b76e451c8e42b0a657c30
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MROH8 SLIT1 DSG4 CLSTN2	2.44e-04	167	81	4	3dfec2fcc36caa6e394efae5e540a6fa28759977
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MROH8 SLIT1 DSG4 CLSTN2	2.44e-04	167	81	4	95b3b5ba3414729f0460a26a0deca48de0cbe33e
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MROH8 SLIT1 DSG4 CLSTN2	2.44e-04	167	81	4	9480739587d51e67a281778b9bddd7b5ffc3ad92
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL16A1 PAMR1 KCND2 SCN7A	2.49e-04	168	81	4	4b2d29a7843bf45922038c093ca7ec0600756adc
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-5_RORB_CMAHP\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MYLK SLIT1 TRIM54 CLSTN2	2.49e-04	168	81	4	1d58731a481ecac84c15affa84f8041dd67d944c
ToppCell	PND10-Immune-Immune_Myeloid-DC-maDC-maDC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNB3 CSF2RB TXNDC17 RNF115	2.55e-04	169	81	4	a83e4078db91ecedee637b28b12ec38640fe45f9
ToppCell	PND10-Immune-Immune_Myeloid-DC-maDC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNB3 CSF2RB TXNDC17 RNF115	2.55e-04	169	81	4	f914aa8899fa170a09da31e5fad86de897ea789b
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL16A1 PAMR1 KCND2 SCN7A	2.67e-04	171	81	4	5d31fc9b60329d4ae3c77e4ca679359d9314397d
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	BTC CLSTN2 EPHA3 MYBPC1	2.73e-04	172	81	4	92e76cbf4807704790f42cf2507e92f85cd3bc92
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4-5_RORB_ASCL1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF462 SCN7A TENM1 EPHA3	2.79e-04	173	81	4	2e35bf2b5534a289d93a09faae660f665c131062
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRIM54 CLSTN2 EPHA3 MYBPC1	2.79e-04	173	81	4	ee972d9cc68755926512fd3bbe1267098c67cd94
ToppCell	facs-Heart-RA-24m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGF2R VWF NOTCH1 CRB1	2.85e-04	174	81	4	42dfb6f42b72e40e203b3ef341117bccf3553d54
ToppCell	facs-Heart-RA-24m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGF2R VWF NOTCH1 CRB1	2.85e-04	174	81	4	f04edf2ca6788875c9918611e416fb739924382e
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL16A1 PAMR1 KCND2 EPHA3	2.91e-04	175	81	4	795a6564d5a75ffd35d39f5274b9e8d28708bbc8
ToppCell	356C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	COL16A1 MYLK SCN7A EPHA3	3.04e-04	177	81	4	cdfd2f0ee2f692271b1525e414b0f645cdadb1f6
ToppCell	356C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|356C / Donor, Lineage, Cell class and subclass (all cells)	COL16A1 MYLK SCN7A EPHA3	3.04e-04	177	81	4	db222faaecbe5600da39277243c4e7e764eb63c9
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GREB1L SCN7A CHRFAM7A CHRNA7	3.11e-04	178	81	4	e86ed30652c2de70f16430f04b78789b87df4af2
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR6 CLSTN2 THSD7B EPHA3	3.17e-04	179	81	4	479116ac65488c60104a053530830763ec1f95b2
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR6 CLSTN2 THSD7B EPHA3	3.17e-04	179	81	4	1dfc0cb8b369aef35c59f3d4c52603dc9f3728c1
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR6 CLSTN2 THSD7B EPHA3	3.17e-04	179	81	4	69a1b3b05c921de6343ffe6ad998aa2b804312a7
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SCN7A THSD7B CHRFAM7A CHRNA7	3.17e-04	179	81	4	c7afbd10072d36a35cd20ae73670d76b9cefd22d
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SCN7A TENM1 THSD7B MYBPC1	3.31e-04	181	81	4	af92b8b7f455210dab502ef6964f3a0162180759
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RNF150 MYLK BTC THSD7B	3.31e-04	181	81	4	25915e2500430a902db37d79a749ce2990b69810
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DIP2A SLIT1 TENM1 CLSTN2	3.31e-04	181	81	4	08f44323bf71b6004a921bbc969c954c75feeb66
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BTC SLC4A5 CRB1 SLC5A1	3.31e-04	181	81	4	092a971661b0aa06c1cdf428dbfa7339a26fb678
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GREB1L SCN7A CHRFAM7A CHRNA7	3.31e-04	181	81	4	03a303cd2f366f09c18b118bbba6f5e3f95ad56c
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL16A1 MYLK PAMR1 SCN7A	3.31e-04	181	81	4	9c157de9d3403e092c907599f2a2c16db5b21131
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL16A1 MYLK PAMR1 CLSTN2	3.31e-04	181	81	4	b116c68393d8836bac080f81a8fcbeb52e0403e7
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GREB1L RNF150 TRIM54 SLC5A1	3.31e-04	181	81	4	719eb532453ab7cd7893726885bc75d74a10b21e
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL16A1 THSD7B CHRFAM7A CHRNA7	3.31e-04	181	81	4	2f3d04d22d4ac016e61709ea5af3d48885c946c4
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL16A1 MYLK PAMR1 SCN7A	3.31e-04	181	81	4	eea943fdcbef0bbaa8578f3296923e874893b405
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL16A1 THSD7B CHRFAM7A CHRNA7	3.38e-04	182	81	4	7dc61e901428cea04f00ebb0939a44d21a6145c6
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF ZAN CSF2RB RAPGEF3	3.38e-04	182	81	4	d0e3663f7d39f22a3ebd7fde56ab3504773598f4
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SCN7A TENM1 THSD7B MYBPC1	3.38e-04	182	81	4	d4cb23b5a974c096a0ce84b47fe351eef44894d7
ToppCell	Pericytes-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	MYLK SLIT1 SCN7A EPHA3	3.45e-04	183	81	4	d04deef7cd4e1738227a6593b84874ce0168c773
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL16A1 MYLK PAMR1 SCN7A	3.45e-04	183	81	4	bc7dd6a40ec9c773d005c1a46f305d40cdd0a326
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-6_RORB_HPCA\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLIT1 CLSTN2 THSD7B EPHA3	3.45e-04	183	81	4	c7e94fe3e7669db9304b249979fef7a69c30a143
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL16A1 THSD7B CHRFAM7A CHRNA7	3.45e-04	183	81	4	5e361be3ae3fe05098968e58427630127bd12675
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CACNG5\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF462 SCN7A TENM1 SLC4A5	3.52e-04	184	81	4	658f2e522055e88c92bc482a845c40f8f5f1a8e3
ToppCell	COVID-19-Heart-CM_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GREB1L RNF150 TRIM54 SLC5A1	3.52e-04	184	81	4	e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SCN7A THSD7B CHRFAM7A CHRNA7	3.60e-04	185	81	4	16e9ccea0e3b95d90dc48ef74206c805681dac0b
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SCN7A THSD7B CHRFAM7A CHRNA7	3.60e-04	185	81	4	487fa382232564f075960899d50afa0edae5d258
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GREB1L SCN7A CHRFAM7A CHRNA7	3.60e-04	185	81	4	79cff4f3c6ae8e5ea60e8eae082b9275f2679ee9
Drug	1-piperidinocyclohexanecarbonitrile	MYLK BRAF SLIT1 GBA2	1.78e-06	25	81	4	CID000062529
Drug	tiotropium	NR2C2 RAPGEF3 CHRFAM7A CHRNA7	8.98e-06	37	81	4	CID000060830
Disease	Congenital aneurysm of ascending aorta	MYLK NOTCH1	7.26e-06	2	80	2	C0345050
Disease	cognitive disorder (implicated_via_orthology)	CHRFAM7A CHRNA7	1.08e-04	6	80	2	DOID:1561 (implicated_via_orthology)
Disease	rheumatoid arthritis (biomarker_via_orthology)	CHRFAM7A CHRNA7	1.08e-04	6	80	2	DOID:7148 (biomarker_via_orthology)
Disease	thyroid gland papillary carcinoma (is_implicated_in)	KMT2D BRAF	3.22e-04	10	80	2	DOID:3969 (is_implicated_in)
Disease	Microphthalmos	KMT2D CRB1	3.93e-04	11	80	2	C0026010
Disease	hemopexin measurement	CFHR5 CRB1	3.93e-04	11	80	2	EFO_0008149
Disease	nicotine dependence (implicated_via_orthology)	CHRFAM7A CHRNA7	4.71e-04	12	80	2	DOID:0050742 (implicated_via_orthology)
Disease	colon carcinoma (is_marker_for)	KMT2D IGF2R	5.55e-04	13	80	2	DOID:1520 (is_marker_for)
Disease	Malignant neoplasm of breast	KMT2D VWF BRAF UBR4 TENM1 DHX32 CFHR5 RNF115 NOTCH1 ZNF404	6.40e-04	1074	80	10	C0006142
Disease	coagulation factor measurement	VWF CFHR5	1.34e-03	20	80	2	EFO_0004634
Disease	response to anticonvulsant	TDRD15 RIN2 CLSTN2	1.62e-03	85	80	3	GO_0036277
Disease	Lymphoma, Non-Hodgkin, Familial	BRAF FPGS	1.62e-03	22	80	2	C4721532
Disease	Carcinoma of lung	BRAF EPHA3	1.77e-03	23	80	2	C0684249
Disease	Cerebral Astrocytoma	BRAF NOTCH1	2.09e-03	25	80	2	C0750935
Disease	Intracranial Astrocytoma	BRAF NOTCH1	2.09e-03	25	80	2	C0750936
Disease	Astrocytoma	BRAF NOTCH1	2.09e-03	25	80	2	C0004114
Disease	Grade I Astrocytoma	BRAF NOTCH1	2.09e-03	25	80	2	C1704230
Disease	Subependymal Giant Cell Astrocytoma	BRAF NOTCH1	2.09e-03	25	80	2	C0205768
Disease	Mixed oligoastrocytoma	BRAF NOTCH1	2.09e-03	25	80	2	C0547065
Disease	Pilocytic Astrocytoma	BRAF NOTCH1	2.09e-03	25	80	2	C0334583
Disease	Juvenile Pilocytic Astrocytoma	BRAF NOTCH1	2.09e-03	25	80	2	C0280783
Disease	Diffuse Astrocytoma	BRAF NOTCH1	2.09e-03	25	80	2	C0280785
Disease	Childhood Cerebral Astrocytoma	BRAF NOTCH1	2.09e-03	25	80	2	C0338070
Disease	Squamous cell carcinoma of esophagus	KMT2D TXNDC17 NOTCH1	2.22e-03	95	80	3	C0279626
Disease	level of Sterol ester (27:1/18:2) in blood serum	TDRD15 BTC	2.26e-03	26	80	2	OBA_2045194
Disease	Gemistocytic astrocytoma	BRAF NOTCH1	2.26e-03	26	80	2	C0334581
Disease	Protoplasmic astrocytoma	BRAF NOTCH1	2.26e-03	26	80	2	C0334580
Disease	Fibrillary Astrocytoma	BRAF NOTCH1	2.26e-03	26	80	2	C0334582
Disease	retinitis pigmentosa (implicated_via_orthology)	USH2A CRB1	2.44e-03	27	80	2	DOID:10584 (implicated_via_orthology)
Disease	Sezary Syndrome	KMT2D BRAF	2.44e-03	27	80	2	C0036920
Disease	Anaplastic astrocytoma	BRAF NOTCH1	2.44e-03	27	80	2	C0334579

Protein segments in the cluster

Peptide	Gene	Start	Entry
IPECCAVYRIQDGEK	BRAF	191	P15056
GCIRVDKITEYLCEP	AP2B1	111	P63010
TNVSYCGVLDEECPV	CACNB3	66	P54284
EGKVYTRCFCLEEPQ	COL16A1	271	Q07092
CVEYCPEVNVMVTGS	BUB3	101	O43684
GCIRVDKITEYLCEP	AP1B1	111	Q10567
EVGYVIPFENCCTNE	DHX32	141	Q7L7V1
KVQCFGEDVCISIPE	CLSTN2	606	Q9H4D0
ECCKEPYPDVTFTVT	CHRNA7	211	P36544
PCLVCGTDAEAIYVT	NUP43	361	Q8NFH3
PQVVEYCVVCGDKAS	NR2C2	111	P49116
CIQEVFPEDTGTYTC	MYLK	681	Q15746
GLYCDVPSVSCEVAA	NOTCH1	1091	P46531
KYDISICGCVPSLVQ	LINS1	551	Q8NG48
PCEIGCVKYSLQEGI	MAEL	136	Q96JY0
PVVDCVVSVPCFYTD	HSPA4	136	P34932
YGLRCVTEECPVAVF	KCNJ12	146	Q14500
ECPVCYSVLAPGEAV	RBCK1	281	Q9BYM8
GEKQELCCVSLVAVY	CFAP65	1091	Q6ZU64
GTICIEVPDINDYCP	DSG4	481	Q86SJ6
EECVKLNCEQPYVTT	KCND2	581	Q9NZV8
SGVRIVVEYCEPCGF	MIEN1	21	Q9BRT3
RICSQEEVVIPCAYD	MROH8	6	Q9H579
QEVGLACCYVSKEVI	GREB1L	1071	Q9C091
ACCYVSKEVIRGPTV	GREB1L	1076	Q9C091
ECCKEPYPDVTFTVT	CHRFAM7A	121	Q494W8
IEGVAYTSECFPCKP	ELAPOR2	281	A8MWY0
CVIPCQSFVVTDVDY	CSF2RB	96	P32927
SEQISCAKEDPQVYC	GBA2	16	Q9HCG7
CAKEDPQVYCPEETG	GBA2	21	Q9HCG7
CFEVTIELGCVKYPL	CPD	756	O75976
LVPIGKCSCNAGYEE	EPHA3	251	P29320
TCVEQVKTCGYIPEL	CFHR5	261	Q9BXR6
AYDCTNIIRKPVVCG	FPGS	206	Q05932
TPYLCKTDEVGEICV	DIP2A	736	Q14689
TCEPGYTGVNCEVDI	CRB1	1201	P82279
CCEYEAVGKDNPVVL	HINFP	156	Q9BQA5
VAEQTPSCVCDEGYI	BTC	86	P35070
IECVCPGKREVVGYT	PAMR1	51	Q6UXH9
VVGYTIPCCRNEENE	PAMR1	61	Q6UXH9
DNCAVCIEGYKPNDV	RNF150	276	Q9ULK6
TSYACPEEPLECVVT	IGF2R	756	P11717
AGPDFQIKVEVYSCC	RTKN2	166	Q8IZC4
CCEEKYIPFVLNSTG	USH2A	3206	O75445
YCPVEFSKEIVCVPS	SMS	336	P52788
YICPRCESGFIEEVT	RNF115	36	Q9Y4L5
DGYVCVIQVEPFCCV	SLFN14	306	P0C7P3
DCGIYEIVPVCNTKL	TDRD15	1611	B5MCY1
IYIIAGAPTDCDCKI	TENM1	1461	Q9UKZ4
EGCIVTEKVYESESC	POLD3	396	Q15054
VQEGLCVSVPCSVLY	SIGLEC12	161	Q96PQ1
NYEVGSVEGKELLCC	SETDB1	1266	Q15047
SAIPTEKVDGTCCYV	C12orf29	51	Q8N999
EEKINIYCLSCEVPT	TRIM54	131	Q9BYV2
PYITTEDVCQICAEK	RIN2	811	Q8WYP3
SCAIQVGDKVPYDIC	RAPGEF3	551	O95398
QIIYTGEEPYKCEEC	ZNF138	241	P52744
YAPGETVKIGCNTCV	VWF	836	P04275
YEPCCQLLQKAVDTG	STAG3	721	Q9UJ98
VCLEVYEKPVQVPCG	RNF114	31	Q9Y508
DNCVVCFDTYKPQDV	RNF148	256	Q8N7C7
ECEECGKVFSYPANL	ZNF607	171	Q96SK3
PYDCKECGETFISLV	ZNF627	166	Q7L945
PNFITTYKCECVAPD	SLC4A5	671	Q9BY07
EVPAKSDVYCEVCEF	PSAP	306	P07602
YDPVVGCILQEVPCT	WDR6	141	Q9NNW5
TCKACYERGEEVSVV	ZFYVE1	471	Q9HBF4
VIPYECNECGKAFVV	ZNF404	156	Q494X3
SEGCVFIYCQVGEKP	TXNDC17	61	Q9BRA2
VTCGLGYKEETVCEV	TMEM81	51	Q6P7N7
EPQVSEAVYDCVICG	UBR3	1226	Q6ZT12
DPLVNTVVVYDCDVC	ZNF462	1021	Q96JM2
NLVSVGYCCFKPEVI	ZNF510	81	Q9Y2H8
TDAGQCPEGYVCVKA	SCN7A	311	Q01118
KQFTVCDVPLYDICD	TEX29	16	Q8N6K0
SGYIQEKCVIPCPFD	THSD7B	986	Q9C0I4
VVPSECEKYCGTKVG	SLC5A1	346	P13866
CPLQYEGKACEQLVD	SLIT1	1031	O75093
YAKPCCAVDPIENEE	UBR4	3716	Q5T4S7
PICCSEYVKGEVATE	PJA1	596	Q8NG27
VKTPYECQECGERFI	ZNF473	511	Q8WTR7
EGCICQPGYVLSEDK	ZAN	2246	Q9Y493
YACKAGCLDEPVELT	KIAA2013	521	Q8IYS2
FDCVSCQPYVVKPVA	KMT2D	1551	O14686
TYCCKAVNDLGTVEI	MYBPC1	1116	Q00872