Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionI-SMAD binding

SMAD2 SMAD5 SMAD7 SMAD9

2.87e-06171214GO:0070411
GeneOntologyMolecularFunctionhistone modifying activity

USP36 HUWE1 KDM5D MYSM1 SETD2 BRCA2 UHRF1 ATM

7.84e-052291218GO:0140993
GeneOntologyCellularComponentheteromeric SMAD protein complex

SMAD2 SMAD5 SMAD7 SMAD9

7.34e-0881214GO:0071144
GeneOntologyCellularComponentSMAD protein complex

SMAD2 SMAD5 SMAD7 SMAD9

2.18e-07101214GO:0071141
DomainDWB

SMAD2 SMAD5 SMAD7 SMAD9

9.70e-0881164SM00524
DomainMH2

SMAD2 SMAD5 SMAD7 SMAD9

9.70e-0881164PS51076
DomainMH1

SMAD2 SMAD5 SMAD7 SMAD9

9.70e-0881164PS51075
Domain-

SMAD2 SMAD5 SMAD7 SMAD9

9.70e-08811643.90.520.10
DomainMAD_homology_MH1

SMAD2 SMAD5 SMAD7 SMAD9

9.70e-0881164IPR013019
DomainDwarfin

SMAD2 SMAD5 SMAD7 SMAD9

9.70e-0881164IPR013790
DomainMH2

SMAD2 SMAD5 SMAD7 SMAD9

9.70e-0881164PF03166
DomainSMAD_dom_Dwarfin-type

SMAD2 SMAD5 SMAD7 SMAD9

9.70e-0881164IPR001132
DomainMAD_homology1_Dwarfin-type

SMAD2 SMAD5 SMAD7 SMAD9

6.73e-07121164IPR003619
DomainDWA

SMAD2 SMAD5 SMAD7 SMAD9

6.73e-07121164SM00523
DomainMH1

SMAD2 SMAD5 SMAD7 SMAD9

6.73e-07121164PF03165
DomainSMAD_FHA_domain

STARD9 TIFA SMAD2 SMAD5 SMAD7 SMAD9

8.13e-07521166IPR008984
DomainSMAD_dom-like

SMAD2 SMAD5 SMAD7 SMAD9

2.43e-06161164IPR017855
Domain-

SMAD2 SMAD5 SMAD7 SMAD9

2.43e-061611642.60.200.10
Domainzf-C2H2_6

ZNF569 ZNF317 ZNF354B ZNF16 ZNF526 ZNF117 ZNF497 ZNF606 ZNF107

1.51e-043141169PF13912
Pubmed

Smad7 is required for the development and function of the heart.

SMAD2 SMAD5 SMAD7 SMAD9

2.08e-096121418952608
Pubmed

Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells.

SMAD2 SMAD5 SMAD7 SMAD9

9.65e-098121410647776
Pubmed

Computational modelling of Smad-mediated negative feedback and crosstalk in the TGF-β superfamily network.

SMAD2 SMAD5 SMAD7 SMAD9

9.65e-098121423804438
Pubmed

TGF-beta signaling by Smad proteins.

SMAD2 SMAD5 SMAD7 SMAD9

9.65e-098121410708949
Pubmed

Holding their own: the noncanonical roles of Smad proteins.

SMAD2 SMAD5 SMAD7 SMAD9

1.73e-089121419018011
Pubmed

TGF-beta signal transduction.

SMAD2 SMAD5 SMAD7 SMAD9

1.73e-08912149759503
Pubmed

Prdm16 is required for normal palatogenesis in mice.

SMAD2 SMAD5 SMAD7 SMAD9

1.73e-089121420007998
Pubmed

The Smad pathway.

SMAD2 SMAD5 SMAD7 SMAD9

1.73e-089121410708948
Pubmed

Spatio-temporal distribution of Smads and role of Smads/TGF-β/BMP-4 in the regulation of mouse bladder organogenesis.

SMAD2 SMAD5 SMAD7 SMAD9

2.88e-0810121423620745
Pubmed

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor.

SMAD2 SMAD5 SMAD7 SMAD9

2.88e-081012149436979
Pubmed

Smad7-induced beta-catenin degradation alters epidermal appendage development.

SMAD2 SMAD5 SMAD7 SMAD9

4.51e-0811121416950122
Pubmed

Smad expression during kidney development.

SMAD2 SMAD5 SMAD7 SMAD9

6.75e-0812121414656760
Pubmed

Pot1a prevents telomere dysfunction and ATM-dependent neuronal loss.

POT1 XRCC2 BRCA2 ATM

1.36e-0714121424899707
Pubmed

Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus.

SMAD2 SMAD5 SMAD7 SMAD9

1.36e-0714121416435884
Pubmed

Tbx1 genetically interacts with the transforming growth factor-β/bone morphogenetic protein inhibitor Smad7 during great vessel remodeling.

SMAD2 SMAD5 SMAD7 SMAD9

1.85e-0715121423011393
Pubmed

Dynamic signaling network for the specification of embryonic pancreas and liver progenitors.

AFP SMAD2 SMAD5 SMAD9

2.46e-0716121419556507
Pubmed

Smad7 regulates terminal maturation of chondrocytes in the growth plate.

SMAD2 SMAD5 SMAD7 SMAD9

3.20e-0717121423994637
Pubmed

Brightfield proximity ligation assay reveals both canonical and mixed transforming growth factor-β/bone morphogenetic protein Smad signaling complexes in tissue sections.

SMAD2 SMAD5 SMAD9

4.09e-075121325141865
Pubmed

p63 Suppresses non-epidermal lineage markers in a bone morphogenetic protein-dependent manner via repression of Smad7.

SMAD2 SMAD5 SMAD7 SMAD9

4.11e-0718121419717565
Pubmed

Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.

ADAMTS19 SMAD2 SMAD5 SMAD9

4.11e-0718121435503090
Pubmed

Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium.

SMAD2 SMAD7 SMAD9

8.15e-07612139256479
Pubmed

Regeneration of axons in injured spinal cord by activation of bone morphogenetic protein/Smad1 signaling pathway in adult neurons.

SMAD2 SMAD5 SMAD9

8.15e-076121321518886
Pubmed

SMAD expression in the testis: an insight into BMP regulation of spermatogenesis.

SMAD5 SMAD7 SMAD9

8.15e-076121318069690
Pubmed

Dynamic regulation of Smad expression during mesenchyme to epithelium transition in the metanephric kidney.

SMAD2 SMAD5 SMAD9

8.15e-076121311850197
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

THSD7A DYNC2H1 GPAM ANKRD6 ELFN2 MYSM1 SETD2 ZNF526 SAMD9L ZNF606 HECTD1

1.31e-064931211115368895
Pubmed

Man1, an inner nuclear membrane protein, regulates vascular remodeling by modulating transforming growth factor beta signaling.

SMAD2 SMAD5 SMAD7 SMAD9

1.40e-0624121416943282
Pubmed

Regulation of transforming growth factor-beta and bone morphogenetic protein signalling by transcriptional coactivator GCN5.

SMAD2 SMAD5 SMAD9

1.42e-067121315009097
Pubmed

Can't get no SMADisfaction: Smad proteins as positive and negative regulators of TGF-beta family signals.

SMAD2 SMAD5 SMAD7

1.42e-067121310376010
Pubmed

Negative regulation of BMP/Smad signaling by Tob in osteoblasts.

SMAD2 SMAD5 SMAD9

1.42e-067121311163184
Pubmed

Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction.

SMAD2 SMAD5 SMAD9

1.42e-067121315376321
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

COL28A1 ICA1 GPAM HUWE1 GMPS SLC38A10 SAMD9L NEUROD2 PDLIM1 CLTC TMPO CHD6 ATM

1.85e-067361211329676528
Pubmed

A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension.

SMAD2 SMAD5 SMAD9

2.27e-068121319211612
Pubmed

TGFβ Induces a SAMHD1-Independent Post-Entry Restriction to HIV-1 Infection of Human Epithelial Langerhans Cells.

IFNB1 SMAD2 MX2

2.27e-068121327375111
Pubmed

Single-cell analysis identifies a key role for Hhip in murine coronal suture development.

HHIP SMAD2 SMAD5 SMAD9

2.68e-0628121434880220
Pubmed

GATA4 is essential for bone mineralization via ERα and TGFβ/BMP pathways.

SMAD2 SMAD5 SMAD9

3.40e-069121324932701
Pubmed

A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage.

ATM IKBKB MAP2K6

3.40e-069121321606198
Pubmed

Smad7 Protein Interacts with Receptor-regulated Smads (R-Smads) to Inhibit Transforming Growth Factor-β (TGF-β)/Smad Signaling.

SMAD2 SMAD7 SMAD9

3.40e-069121326555259
Pubmed

Combinatorial Smad2/3 Activities Downstream of Nodal Signaling Maintain Embryonic/Extra-Embryonic Cell Identities during Lineage Priming.

SMAD2 SMAD5 SMAD9

3.40e-069121330134160
Pubmed

Altered primordial germ cell migration in the absence of transforming growth factor beta signaling via ALK5.

SMAD2 SMAD5 SMAD9

3.40e-069121315993878
Pubmed

Interactions between BMP-7 and USAG-1 (uterine sensitization-associated gene-1) regulate supernumerary organ formations.

SMAD2 SMAD5 SMAD9

3.40e-069121324816837
Pubmed

Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway.

SMAD2 SMAD5 SMAD9

3.40e-069121314729481
Pubmed

Genetic polymorphisms in double-strand break DNA repair genes associated with risk of oral premalignant lesions.

XRCC2 BRCA2 ATM

3.40e-069121318579371
Pubmed

Dullard/Ctdnep1 regulates endochondral ossification via suppression of TGF-β signaling.

SMAD2 SMAD5 SMAD9

3.40e-069121325155999
Pubmed

Sma- and Mad-related protein 7 (Smad7) is required for embryonic eye development in the mouse.

SMAD2 SMAD5 SMAD7 SMAD9

3.56e-0630121423426374
Pubmed

TGF-β signaling inhibits canonical BMP signaling pathway during palate development.

SMAD2 SMAD5 SMAD9

4.84e-0610121329247325
Pubmed

Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).

SMAD2 SMAD5 SMAD7

4.84e-0610121315221015
Pubmed

Protein Arginine Methyltransferase PRMT1 Is Essential for Palatogenesis.

SMAD2 SMAD5 SMAD9

4.84e-0610121329986157
Pubmed

Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation.

AFP SMAD5 SMAD9

4.84e-0610121311566864
Pubmed

Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice.

AFP SMAD2 SMAD5

4.84e-0610121312543979
Pubmed

ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress.

ATM IKBKB MAP2K6

4.84e-0610121320932476
Pubmed

Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate.

SMAD2 SMAD5 SMAD9

6.64e-0611121327741240
Pubmed

Downregulation of bone morphogenetic protein receptor axis during HIV-1 and cocaine-mediated pulmonary smooth muscle hyperplasia: implications for HIV-related pulmonary arterial hypertension.

SMAD2 SMAD5 SMAD9

6.64e-0611121324008158
Pubmed

Sexually dimorphic gene expression in the developing mouse gonad.

ADAMTS19 KDM5D PTGDS HHIP

6.71e-0635121412617826
Pubmed

BMPR-II is dispensable for formation of the limb skeleton.

SMAD2 SMAD5 SMAD9

8.83e-0612121321538804
Pubmed

Connexin 40, a target of transcription factor Tbx5, patterns wrist, digits, and sternum.

SMAD2 SMAD5 SMAD9

8.83e-0612121315923624
Pubmed

Crim1KST264/KST264 mice implicate Crim1 in the regulation of vascular endothelial growth factor-A activity during glomerular vascular development.

SMAD2 SMAD5 SMAD9

8.83e-0612121317460146
Pubmed

Expression and functional analysis of the Wnt/beta-catenin induced mir-135a-2 locus in embryonic forebrain development.

NEUROD2 SMAD5 SMAD9

8.83e-0612121327048518
Pubmed

Impaired Annulus Fibrosus Development and Vertebral Fusion Cause Severe Scoliosis in Mice with Deficiency of c-Jun NH2-Terminal Kinases 1 and 2.

SMAD2 SMAD5 SMAD9

8.83e-0612121330664861
Pubmed

Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic hearts.

SMAD2 SMAD5 SMAD9

1.15e-0513121316959237
Pubmed

Enhanced BMP signaling results in supernumerary tooth formation in USAG-1 deficient mouse.

SMAD2 SMAD5 SMAD9

1.15e-0513121318329379
Pubmed

Excess NF-κB induces ectopic odontogenesis in embryonic incisor epithelium.

IKBKB SMAD5 SMAD9

1.15e-0513121325376721
Pubmed

Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy.

HHIP SMAD5 SMAD9

1.15e-0513121318434416
Pubmed

Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis.

SMAD5 SMAD7 SMAD9

1.15e-0513121320065295
Pubmed

Endoglin is required for myogenic differentiation potential of neural crest stem cells.

SMAD2 SMAD5 SMAD9

1.15e-0513121317628518
Pubmed

Skp2 overexpression is associated with loss of BRCA2 protein in human prostate cancer.

SKP2 BRCA2

1.20e-052121221514447
Pubmed

Antagonistic effects of Smad2 versus Smad7 are sensitive to their expression level during tooth development.

SMAD2 SMAD7

1.20e-052121211557747
Pubmed

Tim/Timeless, a member of the replication fork protection complex, operates with the Warsaw breakage syndrome DNA helicase DDX11 in the same fork recovery pathway.

ARHGEF5 DDX11

1.20e-052121226503245
Pubmed

Metastatic Prostate Cancers with BRCA2 versus ATM Mutations Exhibit Divergent Molecular Features and Clinical Outcomes.

BRCA2 ATM

1.20e-052121237126020
Pubmed

Alpha-fetoprotein and Fanconi Anemia: Relevance to DNA Repair and Breast Cancer Susceptibility.

BRCA2 AFP

1.20e-052121227690720
Pubmed

Identification of an E3 ligase that targets the catalytic subunit of RNA Polymerase I upon transcription stress.

POLR1A SKP2

1.20e-052121236372232
Pubmed

A gene trap integration provides an early in situ marker for hepatic specification of the foregut endoderm.

AFP ANKRD17

1.20e-052121211165478
Pubmed

Extreme Response to High-dose Testosterone in BRCA2- and ATM-mutated Prostate Cancer.

BRCA2 ATM

1.20e-052121227692705
Pubmed

Interferon but not MxB inhibits foamy retroviruses.

IFNB1 MX2

1.20e-052121226609934
Pubmed

Association between pathogenic germline mutations in BRCA2 and ATM and tumor-infiltrating lymphocytes in primary prostate cancer.

BRCA2 ATM

1.20e-052121234533610
Pubmed

Expression of Smad protein by normal skin fibroblasts and hypertrophic scar fibroblasts in response to transforming growth factor beta1.

SMAD2 SMAD7

1.20e-052121218616749
Pubmed

Dual oxidase 2 is essential for the toll-like receptor 5-mediated inflammatory response in airway mucosa.

DUOX2 TLR5

1.20e-052121221714724
Pubmed

Matrix GLA protein, an inhibitory morphogen in pulmonary vascular development.

SMAD2 SMAD5 SMAD9

1.45e-0514121317670744
Pubmed

The chromatin regulator Ankrd11 controls cardiac neural crest cell-mediated outflow tract remodeling and heart function.

SMAD2 SMAD5 SMAD9

1.45e-0514121338951500
Pubmed

Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells.

SMAD5 SMAD7 SMAD9

1.45e-0514121326952187
Pubmed

Loss of Smad4 in the scleraxis cell lineage results in postnatal joint contracture.

SMAD2 SMAD5 SMAD9

1.45e-0514121333248111
Pubmed

The function of growth/differentiation factor 11 (Gdf11) in rostrocaudal patterning of the developing spinal cord.

SMAD2 SMAD5 SMAD9

1.45e-0514121316790475
Pubmed

Spatiotemporal disorder in the axial skeleton development of the Mesp2-null mouse: a model of spondylocostal dysostosis and spondylothoracic dysostosis.

SMAD2 SMAD5 SMAD9

1.45e-0514121323238123
Pubmed

An atypical canonical bone morphogenetic protein (BMP) signaling pathway regulates Msh homeobox 1 (Msx1) expression during odontogenesis.

SMAD2 SMAD5 SMAD9

1.45e-0514121325274628
Pubmed

Constitutively active mutation of ACVR1 in oral epithelium causes submucous cleft palate in mice.

SMAD2 SMAD5 SMAD9

1.81e-0515121326116174
Pubmed

Epicardial calcineurin-NFAT signals through Smad2 to direct coronary smooth muscle cell and arterial wall development.

SMAD2 SMAD5 SMAD9

1.81e-0515121323946498
Pubmed

The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.

SMAD5 SMAD7 SMAD9

2.23e-0516121321907140
Pubmed

Spatial and temporal expression of molecular markers and cell signals during normal development of the mouse patellar tendon.

SMAD2 SMAD5 SMAD9

2.23e-0516121321939397
Pubmed

Quantitative Proteomics of the SMAD (Suppressor of Mothers against Decapentaplegic) Transcription Factor Family Identifies Importin 5 as a Bone Morphogenic Protein Receptor SMAD-specific Importin.

SMAD2 SMAD5 SMAD7 SMAD9

2.41e-0548121427703004
Pubmed

SMAD4 is essential for generating subtypes of neurons during cerebellar development.

SMAD2 SMAD5 SMAD9

2.70e-0517121322370000
Pubmed

Sexual Fate Change of XX Germ Cells Caused by the Deletion of SMAD4 and STRA8 Independent of Somatic Sex Reprogramming.

TLR5 SMAD5 SMAD9

2.70e-0517121327606421
Pubmed

TGF-β-activated kinase 1 (Tak1) mediates agonist-induced Smad activation and linker region phosphorylation in embryonic craniofacial neural crest-derived cells.

SMAD2 SMAD5 SMAD9

3.23e-0518121323546880
Pubmed

Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors.

SMAD2 SMAD5 SMAD9

3.23e-0518121319914233
Pubmed

Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling during Branching Morphogenesis of the Murine Lung.

SMAD2 SMAD5 SMAD9

3.23e-0518121327720610
Pubmed

BRCA2 is required for neurogenesis and suppression of medulloblastoma.

BRCA2 ATM

3.59e-053121217476307
Pubmed

Non-canonical cyclic AMP SMAD1/5/8 signalling in human granulosa cells.

SMAD5 SMAD9

3.59e-053121230953749
Pubmed

Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE study.

BRCA2 ATM

3.59e-053121215084244
Pubmed

TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6.

TIFA IKBKB

3.59e-053121215492226
Pubmed

Direct visualization of Smad1/5/8-mediated transcriptional activity identifies podocytes and collecting ducts as major targets of BMP signalling in healthy and diseased kidneys.

SMAD5 SMAD9

3.59e-053121221381028
Pubmed

Mutations in ATM, NBN and BRCA2 predispose to aggressive prostate cancer in Poland.

BRCA2 ATM

3.59e-053121232875559
Pubmed

Integrin alpha 11 is a novel type I interferon stimulated gene.

ITGA11 IFNB1

3.59e-053121216697656
InteractionCXXC5 interactions

ATM SMAD5 SMAD7 SMAD9

7.79e-06221194int:CXXC5
InteractionSMAD7 interactions

SKP2 ATM ZNF107 MAP2K6 SMAD2 SMAD7 SMAD9

1.04e-051271197int:SMAD7
GeneFamilySMAD family

SMAD2 SMAD5 SMAD7 SMAD9

4.52e-088934750
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZFP3 ZNF569 ZNF180 ZNF317 ZNF354B ZNF16 ZNF526 ZNF117 ZNF497 ZNF606 ZNF107

1.13e-03718931128
GeneFamilyAnkyrin repeat domain containing

ANKRD6 OSBPL1A ANKRD17 HECTD1 ANKFN1 AGAP3

1.56e-03242936403
GeneFamilyCD molecules|C-type lectin domain family|Killer cell lectin like receptors

KLRF1 KLRC1

1.67e-0312932621
CoexpressionGSE21546_WT_VS_SAP1A_KO_ANTI_CD3_STIM_DP_THYMOCYTES_DN

THSD7A ZNF569 PARP8 POT1 RANBP6 SAMD9L HNRNPUL2 STARD9 SLCO2A1

3.96e-072001219M7532
ToppCell10x5'-Lung-Lymphocytic_Invariant-Inducer-like-ILC3|Lung / Manually curated celltypes from each tissue

LETM2 PSKH1 THAP10 KDM5D XRCC2 STARD9 FARP1 MAP2K6

4.62e-0818712180e7aa481effdd8c2fbdf8b65852821dec2d92cde
ToppCellpdx-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

XRCC2 RGS3 DDX11 BRCA2 CCDC138 UHRF1 TMPO

9.02e-071901217d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCellLPS_only-Epithelial_airway-airway_epithelial|LPS_only / Treatment groups by lineage, cell group, cell type

TDRD9 DUOX2 CFAP65 SLC9A4 SPINK7 ANKFN1 HYDIN

1.19e-061981217e035380578c01b0243bfef29ca9b50cc17cce771
ToppCellLPS_only-Epithelial_airway|LPS_only / Treatment groups by lineage, cell group, cell type

TDRD9 DUOX2 CFAP65 SLC9A4 SPINK7 ANKFN1 HYDIN

1.19e-061981217ba090210392e001a3f7bdf09371b3f0e0c8c7ef3
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

TDRD9 DUOX2 CFAP65 LRRC9 SLC9A4 ANKFN1 HYDIN

1.27e-06200121796701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated|COVID-19_Mild / Disease, condition lineage and cell class

PARP8 HUWE1 RGS3 KLRF1 SAMD9L NBPF10 KLRC1

1.27e-0620012172281debd86e5d92e8fe0397aec9ef670800f7471
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DUOX2 CFAP65 LRRC9 SLC9A4 ANKFN1 HYDIN

4.21e-0615512165f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DUOX2 CFAP65 LRRC9 SLC9A4 ANKFN1 HYDIN

4.21e-0615512160944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCell367C-Lymphocytic-NK_cells-NK_cell_C|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TDRD9 PTGDS KLRF1 PXDNL ANKFN1 SMAD9

4.36e-061561216e6798d2b9c2c1fc6525c24f596f25aa85a375651
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZNF569 FOXN3 KLRF1 STARD9 TRAF3IP3 KLRC1

6.46e-061671216ded4d6cccd3660662f12cf5a512de31d26325f1b
ToppCelldroplet-Fat-Bat-18m-Myeloid-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PARP8 KDM5D TLR5 CCDC138 ATP6V0D2 ZNF606

6.68e-0616812166fddc957a0503455d8c165862b5eb8e5fdb8a510
ToppCelldroplet-Fat-Bat-18m-Myeloid-myeloid_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PARP8 KDM5D TLR5 CCDC138 ATP6V0D2 ZNF606

6.68e-061681216794035cb63353a7d02fd9939deb5b4d075c9d95a
ToppCelldroplet-Fat-Bat-18m-Myeloid|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PARP8 KDM5D TLR5 CCDC138 ATP6V0D2 ZNF606

6.68e-0616812161e23b634f96e88b976a523ca1f3fc08f6fe9b239
ToppCellIPF-Lymphoid-NK|IPF / Disease state, Lineage and Cell class

PARP8 PTGDS KLRF1 TRAF3IP3 ATM KLRC1

1.31e-051891216d92e880162450f8d01e4b8784eb625275cb8e03e
ToppCellASK428-Immune-NK_cell|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq

PARP8 PTGDS KLRF1 SBF1 TRAF3IP3 KLRC1

1.35e-051901216d649f7e17c4227787465dfc02037f791ff85378b
ToppCellCOVID-19-Endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

VIPR1 THSD7A LRRC32 PDLIM1 SLCO2A1 SMAD9

1.35e-0519012169fbd92cd6d4683b2490504d29c43cf42020433d4
ToppCellChildren_(3_yrs)-Immune-natural_killer_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

PARP8 RGS3 KLRF1 TRAF3IP3 ATM KLRC1

1.39e-0519112169b8b64a36e27a2523b8730c7922fd7ad865a021e
ToppCellIPF-Lymphoid-NK|World / Disease state, Lineage and Cell class

PARP8 PTGDS KLRF1 TRAF3IP3 ATM KLRC1

1.39e-051911216f206159b9d5e84cf14a65bfdc008895cec5a8081
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

XRCC2 DDX11 HHIP BRCA2 SLCO2A1 UHRF1

1.47e-051931216bbdfda6665941cfa1965418bb91ef9ff43b1326f
ToppCellChildren_(3_yrs)-Immune-natural_killer_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

PARP8 RGS3 KLRF1 TRAF3IP3 ATM KLRC1

1.47e-0519312161cb666375bc4e1b11a146d20896c9b5ae6fd0887
ToppCellLAM-Endothelial-VasEndo-2|LAM / Condition, Lineage and Cell class

VIPR1 THSD7A LRRC32 PTGDS SLCO2A1 SMAD9

1.56e-051951216bd11d771938251c091a50d559a2c38d1c4a04033
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-lymphocytic-innate_lymphocytic|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PTGDS KLRF1 TRAF3IP3 ATM KLRC1 SMAD7

1.61e-0519612162849c8f06518c9523093b86167daea4c0b9eda73
ToppCellMild|World / Disease group and Cell class

PARP8 SAMD9L KCNA3 ZNF107 KLRC1 MX2

1.61e-0519612165e4ed4a5a437cfa002b92775992a791e27aa4c27
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-lymphocytic-innate_lymphocytic-mature_NK_T_cell|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PTGDS KLRF1 TRAF3IP3 ATM KLRC1 SMAD7

1.61e-051961216bd251231288c900b23d3a676ceec6ac07d228917
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_NK-natural_killer_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PARP8 PTGDS RGS3 KLRF1 ATM KLRC1

1.65e-051971216550cce374332c49893bcf4ce4b7dceb7f5fe26aa
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PTGDS RGS3 KLRF1 SAMD9L ATM KLRC1

1.70e-0519812160e918e9db9b884f5328d438e90efe065e27266ee
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PTGDS RGS3 KLRF1 SAMD9L ATM KLRC1

1.70e-051981216ce92d5fbc2eac27fb246b044fb1914ab92506275
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

PTGDS RGS3 KLRF1 SAMD9L ATM KLRC1

1.70e-051981216fed823d6e684d113bcc9ff3cd1803bb001aa02fa
ToppCellLPS_only-Epithelial_airway-airway_epithelial-Ciliated|LPS_only / Treatment groups by lineage, cell group, cell type

CFAP65 LRRC9 SLC9A4 UHRF1 ANKFN1 HYDIN

1.70e-0519812166d90b541fde357fbb40f8f7d4e8628a48b679718
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PTGDS RGS3 KLRF1 SAMD9L ATM KLRC1

1.70e-0519812161ef3a6bd681c223eed58300348adfef89df5563c
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_NK-natural_killer_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PARP8 PTGDS RGS3 KLRF1 ATM KLRC1

1.70e-0519812165607e36f393cb399fcc2504502498453fd32d96b
ToppCellCOVID-19_Severe-Lymphoid_T/NK-NK_activated|COVID-19_Severe / Disease group, lineage and cell class

PTGDS RGS3 KLRF1 SAMD9L ATM KLRC1

1.75e-051991216edf5f80b4c299e6bf462675f2cd3329d86c923d8
ToppCellmedial-Hematologic-Natural_Killer|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PARP8 PTGDS KLRF1 TRAF3IP3 ATM KLRC1

1.75e-0519912164a75ef6a3b7b5d779a08d039a79322cd60b4ef65
ToppCellmedial-2-Hematologic-Natural_Killer|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PARP8 PTGDS KLRF1 TRAF3IP3 ATM KLRC1

1.75e-05199121652338b8970fba0b32578748ba0bec0b344171ca6
ToppCellmedial-Hematologic-Natural_Killer-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PARP8 PTGDS KLRF1 TRAF3IP3 ATM KLRC1

1.75e-051991216dfcc4976688c7e6df5e41ae77436710075f1f779
ToppCellTracheal-10x3prime_v2-Immune_Lymphocytic-T-T_CD3-NKT|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

PARP8 KLRF1 CD5 TRAF3IP3 ATM KLRC1

1.80e-052001216846d3f0e647040d0e372df0dfcd69a21d5da5aea
ToppCellLung_Parenchyma-Control-Myeloid-Macrophage-Macrophages-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

VIPR1 THSD7A LRRC32 PTGDS SLCO2A1 SMAD9

1.80e-05200121698f6a86fbbe5305c71dae91e7278de9813827935
ToppCellTracheal-10x3prime_v2-Immune_Lymphocytic-T-T_CD3|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

PARP8 KLRF1 CD5 TRAF3IP3 ATM KLRC1

1.80e-052001216c70f06b243ae9804f97308ee02b4b5e1a4a6f9f3
ToppCellLPS_IL1RA-Endothelial-Endothelial-Artery|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

THSD7A LRRC32 RGS3 PDLIM1 NECAB1 CCL1

1.80e-052001216ac9ead34afa14067171833f5c277eaf06db7b02e
ToppCellmild-NK|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

PTGDS RGS3 KLRF1 SAMD9L ATM KLRC1

1.80e-052001216a11fb1d7e124c352eb73fea0e0ec0fed577c97f7
ToppCellParenchyma_Control_(B.)-Endothelial-TX-Macrophages|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

VIPR1 THSD7A LRRC32 PTGDS SLCO2A1 SMAD9

1.80e-052001216d7b89a721988660d8010c804916f5d0ef2520ee2
ToppCellLung_Parenchyma-Control-Myeloid-Macrophage-Macrophages|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

VIPR1 THSD7A LRRC32 PTGDS SLCO2A1 SMAD9

1.80e-0520012161ed1c673184f0c6aae04f90edbb1383b1c1f64d9
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-T/NK-NK_activated|COVID-19_Severe / Disease, condition lineage and cell class

PTGDS RGS3 KLRF1 SAMD9L ATM KLRC1

1.80e-0520012166a77f9643646bafc1157bf1fc1e4c614860ee642
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-T-T_CD8-CD8_CTL|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PARP8 KLRF1 CD5 KCNA3 TRAF3IP3 ATM

1.80e-052001216b76f000582b38f4c61b44081eba9ae213382cb6f
ToppCellLung_Parenchyma-Control-Myeloid-Macrophage|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

VIPR1 THSD7A LRRC32 PTGDS SLCO2A1 SMAD9

1.80e-0520012162a1ba87ca4adf351ef8fa2b3154b86a5407b8f2f
ToppCellCOVID-19_Severe-NK_activated|COVID-19_Severe / Disease condition and Cell class

PTGDS RGS3 KLRF1 SAMD9L KLRC1 MX2

1.80e-052001216f1f6c7f7f75f891c9ccf6bf58f4d65b9cf10bbd8
ToppCell343B-Lymphocytic-NK_cells-NK_cell_A2|343B / Donor, Lineage, Cell class and subclass (all cells)

ZNF317 VPS9D1 CD5 ELMO2 TRAF3IP3

3.16e-0513312158ff1cf0ea1fc33fe8384c0e65c1ee1853b25a2ae
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_1|368C / Donor, Lineage, Cell class and subclass (all cells)

ARHGEF5 ZNF180 ICA1 IKBKB MX2

5.26e-05148121580470353e12599440f711b6e107730763376d04d
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PARP8 KLRF1 KCNA3 TRAF3IP3 KLRC1

6.16e-051531215d8773ee16c7d3e0834b9f64054d42336d6f9833b
ToppCellLPS_only-Epithelial_airway-Ciliated_cells-Ciliated|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP65 LRRC9 SLC9A4 ANKFN1 HYDIN

6.36e-0515412159ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCellLPS_only-Epithelial_airway-Ciliated_cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP65 LRRC9 SLC9A4 ANKFN1 HYDIN

6.36e-05154121558072ce422d09f2de602580325eaac6c4ec6c136
ToppCell343B-Lymphocytic-NK_cells-NK_cell_E|343B / Donor, Lineage, Cell class and subclass (all cells)

ZNF569 ZNF180 DDX11 ZNF526 CCDC138

6.96e-0515712150362c04b7b0b5017964b3a73ee678ae53e7238d7
ToppCellPND07-28-samps-Lymphocyte-T_cells|PND07-28-samps / Age Group, Lineage, Cell class and subclass

CPA3 KDM5D CD5 TRAF3IP3 KLRC1

6.96e-051571215f3b4cde52423246ae6fc4924cd1ee502cf6c009c
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Epithelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TDRD9 DYNC2H1 DDX11 ATP6V0D2 DMBT1

7.18e-05158121512661763d1c309106801cb710c04cd2b62d16cba
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Epithelial-epithelial_cell_of_thymus|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TDRD9 DYNC2H1 DDX11 ATP6V0D2 DMBT1

7.18e-051581215e7db50d6dfaf7280a73a0d5b5aa4f43ea2762d72
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Epithelial-TECs|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TDRD9 DYNC2H1 DDX11 ATP6V0D2 DMBT1

7.18e-0515812150792c39e6fc0745095af7812de2d50949540d60f
ToppCellTracheal-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD56bright|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ZNF569 PARP8 KLRF1 TRAF3IP3 KLRC1

7.18e-051581215607a13a3991953c1a98cc2fe90099b60487ca4f1
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_low-phase|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

XRCC2 DDX11 BRCA2 EFR3B NLRP4

7.18e-051581215d72d6527dc50207ddbada262460d3c4bac249a19
ToppCell10x5'-bone_marrow-Mast|bone_marrow / Manually curated celltypes from each tissue

THSD7A DUOX2 CPA3 RNASE2 ATP1A4

7.39e-051591215c3d3570e83c5d25cc92fa3a7a8f0dc2f89a72913
ToppCellHealthy_Control-Myeloid-Macrophages-|Healthy_Control / Condition, Lineage, Cell class and cell subclass

KCNH7 KDM5D CD5 TRAF3IP3 KLRC1

7.84e-051611215d0482666479530cd2fd0d229cbb59a1d79839477
ToppCellCOVID-CD8-memory_CD4|COVID / Condition, Cell_class and T cell subcluster

DYNC2H1 PTGDS ZNF354B GLE1 CCDC138

8.08e-05162121522b2a32217d357146c117e618813d451510a1801
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DUOX2 CFAP65 LRRC9 SLC9A4 ANKFN1

8.56e-051641215e4d4c59aebe5cacd4ecdb907facd044dc82a831d
ToppCellnormal-na-Lymphocytic_NK-NK_bright-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

PARP8 KDM5D KLRF1 ATM KLRC1

8.56e-051641215b5a91f2cbfad9a2bc38aea576085a37865df955d
ToppCellPCW_07-8.5-Epithelial-Epithelial_ciliated-epi_ciliated_(14)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

KCNH7 CFAP65 LRRC9 ZNF804B HYDIN

8.81e-0516512150c714e852f912b5749de4cb0895406673979b2e6
ToppCellPCW_07-8.5-Epithelial-Epithelial_ciliated|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

KCNH7 CFAP65 LRRC9 ZNF804B HYDIN

8.81e-05165121582530f96aaefe28a13bad0474bbad043f127a86c
ToppCellIonocyte-iono-3|World / Class top

THSD7A ZFP3 GPAM XRCC2 ANKRD6

9.06e-0516612159c4a780f8af46d7552077c7a0ae0ab1b2413e5d4
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PARP8 PTGDS KLRF1 TRAF3IP3 KLRC1

9.59e-051681215318fa1bd5a9d6ae95042517ef30515b6416b61e4
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PARP8 PTGDS KLRF1 TRAF3IP3 KLRC1

9.59e-05168121575b3998aff704a77895ee3723813d8a3819b7cec
ToppCellASK454-Immune-NK_cell|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq

PTGDS KLRF1 TRAF3IP3 ATM KLRC1

1.01e-04170121584705434234bf2fbb5256bd5a1f6ab54c01c5a51
ToppCell367C-Lymphocytic-NK_cells-NK_cell_D|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

RANBP6 PTGDS KLRF1 ZNF117 CMTR2

1.04e-041711215943fbca8a6ac04052a2a85aca7b21a3461cd96f7
ToppCell343B-Lymphocytic-NK_cells-NK_cell_B2|343B / Donor, Lineage, Cell class and subclass (all cells)

KLRF1 NEUROD2 TRAF3IP3 ATM KLRC1

1.04e-041711215d1c5540e59c64eb233acab53bfd0d68e922a74bb
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD4_INF-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PARP8 CPA3 CD5 TRAF3IP3 MAP2K6

1.04e-041711215e6dfbd2652b67577c8834c05348f62150637f348
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD4_INF|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PARP8 CPA3 CD5 TRAF3IP3 MAP2K6

1.04e-041711215ddaeb96ce9c9c3bf232b4a42266fa2ee7e8f3f41
ToppCellfacs-Lung-3m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

XRCC2 CD5 TRAF3IP3 IKBKB MRPL9

1.04e-041711215f1fdc0ec3399ed6955976d02be7e5fc329a64276
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_NK-natural_killer_cell-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

WIPI1 KDM5D KLRF1 FARP1 KLRC1

1.07e-04172121568fd03f2c8ee01fe46194400f74ede3830e00f34
ToppCellnormal-na-Hematopoietic-Progen-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

COL28A1 KDM5D ELFN2 NECAB1 ATM

1.10e-041731215e666364eb110c1c976e5b09a632dd1454513f131
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPA3 ELFN2 NECAB1 OSBPL1A TIFA

1.13e-041741215a9f34d1237f335d27c5560ff514368f4709f9144
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ARHGEF5 ICA1 HNRNPUL2 IKBKB MX2

1.13e-04174121558300d64d3b6fd9ba1b6c87ea83b2777eb6be2f4
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD7A DUOX2 ANKRD6 NECAB1 TLR5

1.16e-0417512159d082ba0e350162aa6e71b668be074b12a27c7ab
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD7A DUOX2 ANKRD6 NECAB1 TLR5

1.16e-041751215f641f34b52aec5d047430a6f9d026e915da6c11d
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-DN3_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPA3 ELFN2 NECAB1 OSBPL1A TIFA

1.19e-041761215d43d9e86c4d4fa1e88fbf2b899ac7143717aac90
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

XRCC2 HHIP BRCA2 EFR3B UHRF1

1.22e-041771215f925a15d2162d166a5b60edac3517c6b2d6cfbea
ToppCellPSB-critical-LOC-Myeloid-Basophil|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CPA3 PTGDS TRAF3IP3 ATP1A4 SMAD7

1.26e-04178121545bdbb96094c97756e1b6eebd80eadd8472143f2
ToppCellsevere-CD8+_T_naive|severe / disease stage, cell group and cell class

USP53 ZNF180 POT1 MLH3 ZNF606

1.32e-04180121594fe530367b170777f4051a4034cff06d80dbb83
ToppCellCOVID-19-kidney-NK|COVID-19 / Disease (COVID-19 only), tissue and cell type

PARP8 KLRF1 TRAF3IP3 ATM KLRC1

1.36e-0418112158906ee8a7a1616dfe8c3b5c73988416641213629
ToppCelldroplet-Lung-LUNG-30m-Myeloid-alveolar_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC9A4 RNASE2 NECAB1 AFP ATP6V0D2

1.36e-0418112158fcdab61fad2efd324d2b27c58f5a594f1dc15de
ToppCell356C-Lymphocytic-NK_cells-NK_cell_B2|356C / Donor, Lineage, Cell class and subclass (all cells)

RGS3 KLRF1 TRAF3IP3 ATM KLRC1

1.39e-04182121552baef8173df0a55307c375674a37c2488066738
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC9A4 RNASE2 NECAB1 AFP ATP6V0D2

1.39e-041821215be48ce85991bceeff938ba080e6bf9cc62176b05
ToppCellB_cells-ISG-high_B_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

SAMD9L BRCA2 PDLIM1 ZNF107 MX2

1.43e-041831215dc2b00e920efa1dcc2a6265cd1024e3249c9974f
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGA11 THSD7A PTGDS DMBT1 MX2

1.43e-041831215dc9602bed3136db91faeffef177006246dc92743
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA11 CFAP65 LRRC9 TSBP1 HYDIN

1.47e-041841215264e14aa1859cfc0ed5fb40e97ea189aed9ef4a5
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

COL28A1 ICA1 ANKRD6 FARP1 EFR3B

1.47e-041841215102105ae1a5ef6d42a43f6d9b00f12ed0690ddb7
ToppCellCOVID-19-Endothelial_cells-Arterial_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

THSD7A LRRC32 PDLIM1 SLCO2A1 SMAD9

1.47e-0418412150f19494789f38ab1a420545e15e748ca7eb345c3
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA11 CFAP65 LRRC9 TSBP1 HYDIN

1.47e-041841215d7eccbd21c480d907fdc8eff2bf5ae22ae452221
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA11 CFAP65 LRRC9 TSBP1 HYDIN

1.47e-04184121522010cfe0428ebfa40952cc1a1a12ad3d25b35c9
ToppCelldroplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LETM2 SLC9A4 UHRF1 ATP6V0D2 AGAP3

1.51e-041851215b4af9ae4c358b48357cb135b740266e1652d886a
ToppCellControl-T_cells-NK_cells|Control / group, cell type (main and fine annotations)

PARP8 KLRF1 TRAF3IP3 ATM KLRC1

1.51e-041851215755c0998c729f462399f1d5e88adf4bfae31be30
ToppCellCOVID-19_Moderate-NK_activated|World / disease group, cell group and cell class

RGS3 KLRF1 SAMD9L KLRC1 MX2

1.54e-041861215ff8f32f69516bf785224fa12f8139a95359b0279
ToppCell367C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-1|367C / Donor, Lineage, Cell class and subclass (all cells)

PARP8 CD5 KCNA3 TRAF3IP3 KLRC1

1.54e-041861215d4be02813d590aa7ffe0d1553a27d257b9ab77fe
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRC9 C11orf96 CCDC138 TMPO SMAD7

1.54e-0418612154ae3c0fe8640a8d029875cf3f0f5ffbba38e85f8
Drughaloperidol; Down 200; 10uM; MCF7; HT_HG-U133A_EA

DYNC2H1 XRCC2 ANKRD6 SKP2 GLE1 OSBPL1A ATM IKBKB SMAD5

1.16e-0619812191082_DN
Diseasebipolar disorder

LETM2 VIPR1 POLR1A THSD7A TDRD9 HUWE1 ANKRD6 TSBP1 STARD9 CMTR2

9.65e-0557711610MONDO_0004985
Diseasecolorectal cancer (is_implicated_in)

POT1 SETD2 MLH3 ATM SMAD7

1.19e-041211165DOID:9256 (is_implicated_in)
DiseaseBreast Cancer, Familial

XRCC2 BRCA2 ATM

2.22e-04301163C0346153
Diseasecoronary artery disease

WIPI1 KCNH7 THSD7A DYNC2H1 PARP8 DUOX2 ANKRD6 SKP2 FARP1 UHRF1 NLRP4 SMAD2 SMAD7 SMAD9

2.53e-04119411614EFO_0001645
Diseaseinfertility (implicated_via_orthology)

BRCA2 ATM

3.18e-0471162DOID:5223 (implicated_via_orthology)
Diseaseendometrial cancer (is_marker_for)

AFP SMAD2 SMAD7

3.53e-04351163DOID:1380 (is_marker_for)
Diseaseendometrial cancer (is_implicated_in)

MLH3 BRCA2 ATM

3.85e-04361163DOID:1380 (is_implicated_in)
DiseaseGlioma

POT1 BRCA2 ATM DMBT1

3.93e-04871164C0017638
Diseasemelanoma

POT1 GPAM IFNB1 BRCA2 ATM MX2

4.56e-042481166C0025202
Diseaseresponse to clopidogrel, response to acetylsalicylate, major adverse cardiovascular event measurement

NECAB1 AGAP3

5.42e-0491162EFO_0020863, GO_1903492, GO_1903493
Diseasealpha fetoprotein measurement

WIPI1 AFP ANKRD17 ATP1A4

6.65e-041001164EFO_0010583
DiseaseAdenoid Cystic Carcinoma

SETD2 UHRF1 ATM CMTR2

6.65e-041001164C0010606
DiseaseSmall Lymphocytic Lymphoma

POT1 ATM

6.75e-04101162C0855095
DiseaseB-CELL MALIGNANCY, LOW-GRADE

POT1 ATM

6.75e-04101162C1868683
DiseaseColorectal Neoplasms

ZNF569 HHIP MLH3 SLCO2A1 SMAD7 SMAD9

8.12e-042771166C0009404
DiseaseNG-monomethyl-arginine measurement

MAP2K6 ANKFN1

8.23e-04111162EFO_0010510
DiseaseMedulloblastoma

SKP2 BRCA2 ATM

1.01e-03501163C0025149
Diseasepancreatic cancer (is_implicated_in)

ITGA11 XRCC2 BRCA2 ATM

1.02e-031121164DOID:1793 (is_implicated_in)
Diseaseneutrophil count

USP53 DYNC2H1 PARP8 GPAM SETD2 PDLIM1 PRPF4 OSBPL1A NBPF10 UHRF1 ATP6V0D2 TRAF3IP3 ATP1A4 HYDIN

1.07e-03138211614EFO_0004833
DiseaseMalignant neoplasm of breast

ADAMTS19 ZNF569 DYNC2H1 XRCC2 IFNB1 SETD2 BRCA2 AFP FARP1 ATM IKBKB MRPL9

1.08e-03107411612C0006142
DiseaseMammary Carcinoma, Human

DYNC2H1 XRCC2 IFNB1 SETD2 BRCA2 AFP ATM MRPL9

1.13e-035251168C4704874
DiseaseMammary Neoplasms, Human

DYNC2H1 XRCC2 IFNB1 SETD2 BRCA2 AFP ATM MRPL9

1.13e-035251168C1257931
DiseaseMammary Neoplasms

DYNC2H1 XRCC2 IFNB1 SETD2 BRCA2 AFP ATM MRPL9

1.16e-035271168C1458155
Diseaseatopic asthma

LRRC32 RANBP6 SLC9A4 NEUROD2 TSBP1

1.16e-031991165EFO_0010638
Diseasejuvenile polyposis syndrome (implicated_via_orthology)

SMAD5 SMAD9

1.16e-03131162DOID:0050787 (implicated_via_orthology)
DiseaseBreast Carcinoma

DYNC2H1 XRCC2 IFNB1 SETD2 BRCA2 AFP ATM MRPL9

1.32e-035381168C0678222
DiseaseChronic Lymphocytic Leukemia

POT1 CD5 ATM

1.34e-03551163C0023434
Diseaseovarian cancer (is_implicated_in)

POT1 BRCA2 SMAD2

1.41e-03561163DOID:2394 (is_implicated_in)
Diseasebiliary atresia

GPAM ZNF354B ANKFN1

1.41e-03561163MONDO_0008867
Diseaseceliac disease

SLC9A4 TSBP1 ANKFN1 HYDIN

1.57e-031261164EFO_0001060
Diseaseamygdala volume change measurement

PARP8 ZNF804B

1.77e-03161162EFO_0021490
DiseaseColorectal Carcinoma

ZNF569 PARP8 HHIP MLH3 SLCO2A1 TRAF3IP3 SMAD2 SMAD7 SMAD9

1.85e-037021169C0009402
DiseaseBone marrow hypocellularity

MYSM1 BRCA2

2.25e-03181162C1855710
DiseaseMalignant neoplasm of urinary bladder

IFNB1 BRCA2 CHD6 ATM

2.37e-031411164C0005684
DiseaseHereditary Non-Polyposis Colon Cancer Type 2

MLH3 ATM

2.51e-03191162C1333991
DiseaseColorectal cancer, hereditary nonpolyposis, type 1

MLH3 ATM

2.51e-03191162C2936783
DiseaseAdenocarcinoma of prostate

BRCA2 ATM

2.78e-03201162C0007112
Diseasehaptoglobin measurement

CMTR2 HYDIN

3.06e-03211162EFO_0004640
DiseaseBREAST CANCER

BRCA2 ATM

3.06e-03211162114480
Diseasecolorectal cancer, colorectal adenoma

HHIP SLCO2A1 SMAD7 SMAD9

3.10e-031521164EFO_0005406, MONDO_0005575
Diseasecolorectal cancer (is_marker_for)

POT1 SETD2 BRCA2 ATM

3.48e-031571164DOID:9256 (is_marker_for)
DiseaseImmunologic Deficiency Syndromes

MYSM1 ATM

3.67e-03231162C0021051
Diseaseinsular cortex volume measurement

THSD7A FOXN3

3.67e-03231162EFO_0010309
Diseasesmall cell lung carcinoma

DYNC2H1 FOXN3 BRCA2

3.90e-03801163EFO_0000702

Protein segments in the cluster

PeptideGeneStartEntry
QAQILASLQGCRSAK

AGAP3

601

Q96P47
RNTSSICSNEGLIFK

CCL1

51

P22362
QAIIDCLGSRSNKQR

ANXA11

221

P50995
GFSRRCSKLINSSQL

ARHGEF5

1081

Q12774
RLTRSNSKCQGQLEV

CD5

36

P06127
NQIKCLLVGFSTLRN

CMTR2

576

Q8IYT2
LAAFQTRGNQLCSLI

GLE1

276

Q53GS7
NRNTALTLACFQGRT

ANKRD17

1251

O75179
QNLEQKLSGDSRACR

ANKRD6

511

Q9Y2G4
LQVNRLKSAQCGSSI

KLRC1

211

P26715
NLQSVTRGCFDLAQK

RGS3

1151

P49796
RFLRSKASNCLLQTN

ADAMTS19

531

Q8TE59
QLERLNLSGNQICSF

LRRC9

166

Q6ZRR7
TGLRKLNISFNEFTC

LRRC9

716

Q6ZRR7
QSQFLQSRNLKCIAL

PARP8

776

Q8N3A8
QSSCQSGRQLALRLF

KIAA0100

1976

Q14667
ALCKLLELQTFGTNN

LETM2

296

Q2VYF4
QLQKLASERNLFISC

TMPO

266

P42166
SIQTLKEDCNRLQQG

IKBKB

436

O14920
NQTLLQNCKAFRGAS

KCNH7

736

Q9NS40
CSRLLFLNNISKNEE

CFAP65

1456

Q6ZU64
FPNSELLQRLKNCLS

KDM5D

796

Q9BY66
ISQNLLKRASSRCQS

PSKH1

371

P11801
VLNKGFQSSQALRVC

DUOX2

356

Q9NRD8
QRNNLLCNGLSLKSL

EXD2

196

Q9NVH0
SSLKENGSQLRCVQQ

ERAP1

896

Q9NZ08
LFGKAECDTRQSLQQ

MLH3

1431

Q9UHC1
LLKSLLQVSTGFQCN

EFR3B

431

Q9Y2G0
LSCLGLSIVANFQKT

DRAM2

101

Q6UX65
KSRDLLVQQASQCLS

HNRNPUL2

506

Q1KMD3
SGLRFETQLKTLCQF

KCNA3

111

P22001
SCRLQKLGINNVSFS

NLRP4

666

Q96MN2
GNCTKLNLGRVTLSN

ITGA11

81

Q9UKX5
NFLKCSEQLSSGQDI

PCDHGB5

761

Q9Y5G0
GSRQNLCVNEDVKSL

DDX11

261

Q96FC9
TDCLNLFTKQEGVRN

OSBPL1A

416

Q9BXW6
NVFSALCLNARGLQS

HUWE1

606

Q7Z6Z7
QLLQDGLQLRSCTFQ

SBF1

976

O95248
RNSLTCISDFSLQQL

LRRC32

206

Q14392
TQLKQASLSRVLCDN

PXDNL

1246

A1KZ92
QVGDNRCLLQSLKDS

DYNC2H1

1301

Q8NCM8
AIQCARQEKSSSGLN

ATM

216

Q13315
LSKRQFSSGLNKCVI

CCPG1

206

Q9ULG6
LTGTNKSIRKNRNCS

HECTD1

1931

Q9ULT8
KDSSRILNLCNQSFI

HYDIN

821

Q4G0P3
ISVDNTCSLFRGLQK

GMPS

131

P49915
NGTRRNISNKDLCAS

KLRF1

91

Q9NZS2
NRSKNQNSKCIGTDL

CPA3

236

P15088
CINLNSTLFNLGLTK

CCDC138

641

Q96M89
SNLLARKSDVQGSIC

COL28A1

31

Q2UY09
LSDNLCRQTENLKTS

BRCA2

1616

P51587
IKQQRLNRLCEGSSF

ELMO2

541

Q96JJ3
VCDSKRNLSSDQQLI

CHD6

1831

Q8TD26
KQDLAQGRLTCNDTS

FARP1

141

Q9Y4F1
IRSCLNNITNRTAKG

FOXN3

466

O00409
LLGFLQRSSNFQCQK

IFNB1

26

P01574
LCTESLKSNGRVQFL

SPINK7

66

P58062
LLGKICNDTRQIFTS

DMBT1

1836

Q9UGM3
LSTLLCEQQQKDGTF

SLC38A10

296

Q9HBR0
QESQALAKRSCGLFQ

AFP

406

P02771
AQNRIKGCTDNLTLT

PDLIM1

66

O00151
TGKALCFSSQQRLAL

ICA1

116

Q05084
RDLDSKACISIGNQN

MAP2K6

31

P52564
TKGITRCLLNETTNN

POLR1A

1556

O95602
LQCGIFQSISFNREK

TIFA

26

Q96CG3
LSQQDKRRGNQTALC

THSD7A

441

Q9UPZ6
QLQSLFRQCGQVKSI

TDRD9

791

Q8NDG6
EKCFLTQLSGFLANQ

NBPF10

311

Q6P3W6
KSLRSLNNFCSQIGD

PRPF4

216

O43172
DGNKNCRSITVNDLT

SAMD9L

1136

Q8IVG5
EAGNFICQALNRKTS

HMGCL

301

P35914
SSTFLPQCNRQKLLE

GPAM

806

Q9HCL2
DQTNVKLTCLLFSGN

POT1

51

Q9NUX5
GLNLTSTFLRKNQCE

PTGDS

76

P41222
ITFSACSRIGSLQKQ

SLC9A4

691

Q6AI14
LGNFCRTRSLSPQKQ

STARD9

4271

Q9P2P6
LKLCGDSRLSNLQRQ

RANBP6

271

O60518
INLTILCSDSNGKNR

HHIP

446

Q96QV1
RGQLLKLSCNNTLFT

OR9A4

181

Q8NGU2
QRRCKNQNTFLLTTF

RNASE2

61

P10153
FCLGLLSNVNRNSTI

SMAD9

311

O15198
KSRFCLGLLSNVNRN

SMAD5

306

Q99717
RRKQSQCDLLNESTG

ANKFN1

36

Q8N957
LRLISAQGCKVDNSS

ATP1A4

211

Q13733
INVCNENSLFKSLSR

CLTC

931

Q00610
TNVNCQRLSSKEDLG

C12orf40

111

Q86WS4
SLQREQLSSCKLRNS

C11orf96

411

Q7Z7L8
LACNFSLSQNRGTVI

MRPL9

41

Q9BYD2
SNLNKERGDCTSLQS

USP53

731

Q70EK8
STGNNSRLQAELCQK

SLCO2A1

131

Q92959
LAKNSNLVRLNLSGC

SKP2

226

Q13309
LQSTQRSLALAEQKC

TRAF3IP3

301

Q9Y228
ECGRAFNISSNLNKQ

ZNF107

276

Q9UII5
FCLGQLNSDNKSQLV

SMAD7

296

O15105
KLFSSIQGRNVSRSC

VIPR1

91

P32241
AQCGKAFSQRSNLLS

ZNF497

361

Q6ZNH5
RCLFGNQVLQTSSDL

ZNF804B

196

A4D1E1
FCLGLLSNVNRNATV

SMAD2

311

Q15796
LSSNGFQNISRCKEK

SETD2

716

Q9BYW2
NQFSLVSRCLKSNSL

XRCC2

251

O43543
NQCGKTFSLSARLIV

ZNF180

636

Q9UJW8
SCDQKLTNTNRALAL

UHRF1

496

Q96T88
NECGKAFSQRTSLIV

ZNF569

581

Q5MCW4
DCGKTFSQNSVLKNR

ZNF16

241

P17020
EECGKAFNQLSNLTR

ZNF117

336

Q03924
LDCGKRFTQSSNLQQ

ZNF526

531

Q8TF50
TARLNFSGQRNICTL

WIPI1

306

Q5MNZ9
FSGQRNICTLSTIQK

WIPI1

311

Q5MNZ9
QQCLERAQSTAAKLG

VPS9D1

76

Q9Y2B5
CQSLLQDRDTLNFFK

UGT1A6

126

P19224
NACGKLFSQRSSLTN

ZNF354B

581

Q96LW1
FGKRLCNATTQTEEL

THAP10

201

Q9P2Z0
QILILNQNRFSSCSG

TLR5

451

O60602
IQILKCGGTARSQNS

TSBP1

231

Q5SRN2
SQCGNAFRTLSALKI

ZNF317

281

Q96PQ6
NGCAKLDRQTQATTL

USP36

226

Q9P275
RLSKSQNTVFCGRIQ

THOC1

146

Q96FV9
QKQVLSQRSSEFCGL

ZNF606

201

Q8WXB4
NECGKTFRVSSQLIQ

ZFP3

256

Q96NJ6
RGCKASLLTQQDYIN

ATP6V0D2

21

Q8N8Y2
NAITVLQAKCRNGSL

ELFN2

236

Q5R3F8
KCRGQQEITNRLSLA

MX2

326

P20592
LFSKSSRGCLQNEKQ

MYSM1

271

Q5VVJ2
TNLVAGCLQLNSRNF

NEUROD2

201

Q15784
SQSGCLRISIQKLSN

NECAB1

281

Q8N987