Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphorylation-dependent protein binding	NBN ANK3	1.49e-04	10	37	2	GO:0140031
GeneOntologyCellularComponent	BRCA1-C complex	NBN BRCA1	4.55e-05	6	37	2	GO:0070533
GeneOntologyCellularComponent	intercalated disc	DES ANK3 KCNJ11	2.36e-04	68	37	3	GO:0014704
GeneOntologyCellularComponent	cell-cell contact zone	DES ANK3 KCNJ11	6.12e-04	94	37	3	GO:0044291
MousePheno	increased circulating atrial natriuretic factor	SLC4A5 KCNJ11	3.32e-05	5	26	2	MP:0005522
MousePheno	abnormal circulating atrial natriuretic factor level	SLC4A5 KCNJ11	4.97e-05	6	26	2	MP:0005521
Domain	BRCT	NBN PARP4 BRCA1	6.24e-06	19	36	3	PF00533
Domain	BRCT	NBN PARP4 BRCA1	9.88e-06	22	36	3	SM00292
Domain	-	NBN PARP4 BRCA1	1.13e-05	23	36	3	3.40.50.10190
Domain	BRCT	NBN PARP4 BRCA1	1.66e-05	26	36	3	PS50172
Domain	BRCT_dom	NBN PARP4 BRCA1	2.08e-05	28	36	3	IPR001357
Domain	VWA	PARP4 CACNA2D4	5.21e-03	56	36	2	PF00092
Pubmed	BRCA1-mediated ubiquitination inhibits topoisomerase II alpha activity in response to oxidative stress.	BRCA1 TOP2A	1.10e-06	2	37	2	18162055
Pubmed	Ovarian cancer patient with germline mutations in both BRCA1 and NBN genes.	NBN BRCA1	1.10e-06	2	37	2	18940477
Pubmed	Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding.	NBN BRCA1	1.10e-06	2	37	2	25939603
Pubmed	BRCA1 participates in DNA decatenation.	BRCA1 TOP2A	1.10e-06	2	37	2	15965487
Pubmed	Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts.	NBN BRCA1	3.30e-06	3	37	2	12124328
Pubmed	Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors.	BRCA1 TOP2A	3.30e-06	3	37	2	18451150
Pubmed	Breast cancer predisposing alleles in Poland.	NBN BRCA1	3.30e-06	3	37	2	15980987
Pubmed	High frequency of BRCA1, but not CHEK2 or NBS1 (NBN), founder mutations in Russian ovarian cancer patients.	NBN BRCA1	6.60e-06	4	37	2	19338682
Pubmed	Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene.	NBN BRCA1	6.60e-06	4	37	2	19383352
Pubmed	Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.	NBN TOP2A	6.60e-06	4	37	2	27814490
Pubmed	Function of the ATR N-terminal domain revealed by an ATM/ATR chimera.	NBN BRCA1	6.60e-06	4	37	2	17376433
Pubmed	NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain.	NBN BRCA1	6.60e-06	4	37	2	12419185
Pubmed	Triapine disrupts CtIP-mediated homologous recombination repair and sensitizes ovarian cancer cells to PARP and topoisomerase inhibitors.	NBN BRCA1	6.60e-06	4	37	2	24413181
Pubmed	Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response.	NBN BRCA1	6.60e-06	4	37	2	10426999
Pubmed	Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway.	NBN BRCA1	6.60e-06	4	37	2	15175241
Pubmed	Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.	NBN BRCA1	1.10e-05	5	37	2	12792649
Pubmed	Inactivation of the Nijmegen breakage syndrome gene leads to excess centrosome duplication via the ATR/BRCA1 pathway.	NBN BRCA1	1.10e-05	5	37	2	19244116
Pubmed	MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks.	NBN BRCA1	1.10e-05	5	37	2	18678890
Pubmed	Fanconi anemia group J helicase and MRE11 nuclease interact to facilitate the DNA damage response.	NBN BRCA1	1.10e-05	5	37	2	23530059
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TGFBR1 SIAE BIN2 ANK3 INPP5B DOCK9 UGGT1 KIF11	1.50e-05	1084	37	8	11544199
Pubmed	Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.	NBN BRCA1	1.65e-05	6	37	2	18171670
Pubmed	The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair.	NBN BRCA1	1.65e-05	6	37	2	29709199
Pubmed	Genomic instability in mice lacking histone H2AX.	NBN BRCA1	1.65e-05	6	37	2	11934988
Pubmed	GCNA Interacts with Spartan and Topoisomerase II to Regulate Genome Stability.	BRCA1 TOP2A	1.65e-05	6	37	2	31839538
Pubmed	RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.	NBN BRCA1	1.65e-05	6	37	2	18001824
Pubmed	CtIP-BRCA1 complex and MRE11 maintain replication forks in the presence of chain terminating nucleoside analogs.	NBN BRCA1	1.65e-05	6	37	2	30657944
Pubmed	NBS1 prevents chromatid-type aberrations through ATM-dependent interactions with SMC1.	NBN BRCA1	1.65e-05	6	37	2	18763866
Pubmed	Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity.	NBN BRCA1	1.65e-05	6	37	2	16728435
Pubmed	Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.	DES NBN BRCA1 TOP2A	1.91e-05	149	37	4	25184681
Pubmed	Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection.	NBN BRCA1	2.30e-05	7	37	2	25659039
Pubmed	RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.	NBN BRCA1	2.30e-05	7	37	2	18001825
Pubmed	Redistribution of BRCA1 among four different protein complexes following replication blockage.	NBN BRCA1	2.30e-05	7	37	2	11504724
Pubmed	Hepatic stellate cell-derived delta-like homolog 1 (DLK1) protein in liver regeneration.	DES ALCAM	2.30e-05	7	37	2	22298767
Pubmed	Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2.	NBN BRCA1	2.30e-05	7	37	2	22231403
Pubmed	Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.	NBN PARP4 BRCA1	2.80e-05	55	37	3	19536092
Pubmed	Novel obscurins mediate cardiomyocyte adhesion and size via the PI3K/AKT/mTOR signaling pathway.	DES ANK3	3.07e-05	8	37	2	28826662
Pubmed	Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.	NBN BRCA1	3.07e-05	8	37	2	15456891
Pubmed	Loss of function of BRCA1 promotes EMT in mammary tumors through activation of TGFβR2 signaling pathway.	TGFBR1 BRCA1	3.07e-05	8	37	2	35236825
Pubmed	CSB interacts with BRCA1 in late S/G2 to promote MRN- and CtIP-mediated DNA end resection.	NBN BRCA1	3.07e-05	8	37	2	31501894
Pubmed	DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells.	NBN BRCA1	3.07e-05	8	37	2	30464262
Pubmed	Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver.	DES ALCAM	3.95e-05	9	37	2	21294146
Pubmed	Mechanisms of disease: genetic insights into the etiology of type 2 diabetes and obesity.	KCNJ11 KIF11	4.93e-05	10	37	2	18212765
Pubmed	The Deubiquitylating Enzyme USP4 Cooperates with CtIP in DNA Double-Strand Break End Resection.	NBN BRCA1	4.93e-05	10	37	2	26387952
Pubmed	Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.	NBN BRCA1 KRT87P TOP2A NUP210 NOL6	6.01e-05	652	37	6	31180492
Pubmed	Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers.	NBN BRCA1	6.02e-05	11	37	2	19584272
Pubmed	MDC1 is a mediator of the mammalian DNA damage checkpoint.	NBN BRCA1	6.02e-05	11	37	2	12607005
Pubmed	Smad2/Smad3 in endothelium is indispensable for vascular stability via S1PR1 and N-cadherin expressions.	TGFBR1 DES	6.02e-05	11	37	2	22498737
Pubmed	SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint.	NBN BRCA1	6.02e-05	11	37	2	11877377
Pubmed	Polymorphism in nucleotide excision repair gene XPC correlates with bleomycin-induced chromosomal aberrations.	NBN BRCA1	6.02e-05	11	37	2	17685459
Pubmed	Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes.	NBN BRCA1	7.22e-05	12	37	2	16391231
Pubmed	BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.	NBN BRCA1	7.22e-05	12	37	2	10783165
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	TOP2A KIF11 NUP210 NOL6	7.30e-05	210	37	4	16565220
Pubmed	BRCA1 tumor suppressor network: focusing on its tail.	NBN BRCA1	8.53e-05	13	37	2	22369660
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	DES ALCAM BRCA1 TOP2A H4C7 UGGT1 KIF11 NOL6	1.13e-04	1442	37	8	35575683
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	NBN KANK2 GTF3C5 PRRC1 UGGT1 NUFIP2	1.14e-04	733	37	6	34672954
Pubmed	ALK5-mediated transforming growth factor β signaling in neural crest cells controls craniofacial muscle development via tissue-tissue interactions.	TGFBR1 DES	1.15e-04	15	37	2	24912677
Pubmed	CRL4-DCAF8L2 E3 ligase promotes ubiquitination and degradation of BARD1.	BRCA1 KIF11	1.15e-04	15	37	2	35487060
Pubmed	Neuronal-specific deficiency of the splicing factor Tra2b causes apoptosis in neurogenic areas of the developing mouse brain.	TOP2A KIF11	1.31e-04	16	37	2	24586484
Pubmed	Influence of polymorphisms in xenobiotic-metabolizing genes and DNA-repair genes on diepoxybutane-induced SCE frequency.	NBN BRCA1	1.48e-04	17	37	2	17078101
Pubmed	LINC00240 in the 6p22.1 risk locus promotes gastric cancer progression through USP10-mediated DDX21 stabilization.	TOP2A NUFIP2	1.48e-04	17	37	2	37072811
Pubmed	Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers.	UGGT1 NUP210	1.48e-04	17	37	2	32938586
Pubmed	Transcriptomic landscape of early hair follicle and epidermal development.	ALCAM NUP210	1.67e-04	18	37	2	37318953
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	PARP4 BRCA1 UGGT1 KIF11 NUFIP2	1.70e-04	494	37	5	26831064
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	OXCT1 BRCA1 TOP2A UGGT1	1.71e-04	262	37	4	36880596
Pubmed	Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.	SIAE ANK3	1.86e-04	19	37	2	18711365
Pubmed	Pericytes are required for blood-brain barrier integrity during embryogenesis.	DES ALCAM	1.86e-04	19	37	2	20944625
Pubmed	Isolation of a unique hepatic stellate cell population expressing integrin α8 from embryonic mouse livers.	DES ALCAM	1.86e-04	19	37	2	29665133
Pubmed	PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.	KCNJ11 KIF11	2.07e-04	20	37	2	19862325
Pubmed	Effect of germ-line genetic variation on breast cancer survival in a population-based study.	NBN BRCA1	2.07e-04	20	37	2	12036913
Pubmed	Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network.	TGFBR1 ATP2C1 UGGT1 NUP210	2.26e-04	282	37	4	35007762
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	KANK2 GTF3C5 TOP2A NUP210 NOL6 NUFIP2	2.50e-04	847	37	6	35850772
Pubmed	α-Dystrobrevin distribution and association with other proteins in human promyelocytic NB4 cells treated for granulocytic differentiation.	DES BRCA1	2.51e-04	22	37	2	20111909
Pubmed	Gain-of-Function MN1 Truncation Variants Cause a Recognizable Syndrome with Craniofacial and Brain Abnormalities.	TOP2A KIF11	2.51e-04	22	37	2	31839203
Pubmed	Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer.	NBN BRCA1	2.75e-04	23	37	2	16638864
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	NBN ANK3 GTF3C5 TOP2A NUFIP2	2.76e-04	549	37	5	38280479
Pubmed	Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women.	NBN BRCA1	2.99e-04	24	37	2	19950226
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	NBN GTF3C5 TOP2A UGGT1 KIF11	3.03e-04	560	37	5	35241646
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	GTF3C5 TOP2A UGGT1 KIF11 NUP210 NOL6 NUFIP2	3.15e-04	1257	37	7	36526897
Pubmed	The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.	PARP4 TOP2A DOCK9	3.22e-04	125	37	3	29467281
Pubmed	Substrate specificities and identification of putative substrates of ATM kinase family members.	NBN BRCA1	3.25e-04	25	37	2	10608806
Pubmed	Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non-small-cell lung cancer.	NBN BRCA1	3.52e-04	26	37	2	20731661
Pubmed	Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk.	NBN BRCA1	3.80e-04	27	37	2	20610542
Pubmed	Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition.	TOP2A NOL6	4.09e-04	28	37	2	19596686
Pubmed	Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China.	NBN BRCA1	4.09e-04	28	37	2	19661089
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	NBN NUP210 NOL6 NUFIP2	4.65e-04	341	37	4	32971831
Pubmed	Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies.	NBN BRCA1	5.02e-04	31	37	2	20813000
Pubmed	TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin.	NBN BRCA1	5.02e-04	31	37	2	26095369
Pubmed	Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk.	NBN BRCA1	5.02e-04	31	37	2	19690177
Pubmed	RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity.	TOP2A NOL6 NUFIP2	5.07e-04	146	37	3	21589869
Pubmed	A protein interaction landscape of breast cancer.	ATP2C1 BRCA1 ANK3 TOP2A UGGT1	5.33e-04	634	37	5	34591612
Pubmed	Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.	NBN BRCA1	5.69e-04	33	37	2	19714462
Pubmed	Keratin 13 deficiency causes white sponge nevus in mice.	BRCA1 TOP2A	5.69e-04	33	37	2	32758484
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	NBN BRCA1 KANK2 KIF11 NUFIP2	5.76e-04	645	37	5	25281560
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	KANK2 TOP2A NOL6 NUFIP2	5.93e-04	364	37	4	24778252
Pubmed	Foxf2 Is Required for Brain Pericyte Differentiation and Development and Maintenance of the Blood-Brain Barrier.	TGFBR1 DES	6.05e-04	34	37	2	26120030
Pubmed	PTEN identified as important risk factor of chronic obstructive pulmonary disease.	TGFBR1 NBN PARP4 BRCA1	6.57e-04	374	37	4	19625176
Pubmed	Polymorphisms in DNA repair and one-carbon metabolism genes and overall survival in diffuse large B-cell lymphoma and follicular lymphoma.	NBN BRCA1	6.78e-04	36	37	2	18830263
Pubmed	Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.	TGFBR1 NBN PARP4 BRCA1	7.04e-04	381	37	4	18676680
Pubmed	Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.	TGFBR1 NBN PARP4 BRCA1	7.11e-04	382	37	4	19170196
Pubmed	A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility.	NBN BRCA1	7.16e-04	37	37	2	19116388
GeneFamily	Ring finger proteins\|Fanconi anemia complementation groups\|Protein phosphatase 1 regulatory subunits\|BRCA1 A complex\|BRCA1 B complex\|BRCA1 C complex	NBN BRCA1	2.14e-05	5	27	2	1336
Coexpression	DESCARTES_ORGANOGENESIS_MEGAKARYOCYTES	CASS4 SIAE BIN2 RSPH14	7.37e-05	159	37	4	MM3657
Coexpression	GSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_UP	ALCAM BRCA1 TOP2A KIF11	8.11e-05	163	37	4	M8235
Coexpression	GSE13547_CTRL_VS_ANTI_IGM_STIM_ZFX_KO_BCELL_2H_UP	BRCA1 TOP2A PRRC1 KIF11	8.50e-05	165	37	4	M3000
Coexpression	GSE13547_2H_VS_12_H_ANTI_IGM_STIM_BCELL_UP	ALCAM ANK3 TOP2A KIF11	1.09e-04	176	37	4	M2981
Coexpression	JOHNSTONE_PARVB_TARGETS_2_DN	TGFBR1 ALCAM ATP2C1 DOCK9 NUFIP2	1.17e-04	344	37	5	M2239
Coexpression	GSE13547_CTRL_VS_ANTI_IGM_STIM_BCELL_2H_UP	BRCA1 ANK3 TOP2A KIF11	1.27e-04	183	37	4	M2993
Coexpression	BLANCO_MELO_BRONCHIAL_EPITHELIAL_CELLS_INFLUENZA_A_DEL_NS1_INFECTION_DN	BRCA1 KANK2 TOP2A KIF11	1.38e-04	187	37	4	M34027
Coexpression	HE_LIM_SUN_FETAL_LUNG_C2_PRE_PDC_DC5_CELL	ALCAM OXCT1 GTF3C5 INPP5B TOP2A KIF11	1.46e-04	578	37	6	M45744
Coexpression	FUJII_YBX1_TARGETS_DN	OXCT1 BRCA1 TOP2A KIF11	1.59e-04	194	37	4	M14340
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	NBN ALCAM ATP2C1 BRCA1 TOP2A DOCK9 KIF11	1.69e-04	856	37	7	M4500
Coexpression	GSE1566_WT_VS_EZH2_KO_LN_TCELL_DN	PARP4 SLC4A5 NUP210 NUFIP2	1.72e-04	198	37	4	M6224
Coexpression	GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_NFKBP50_KO_MACROPHAGE_UP	SIAE TOP2A KIF11 NUFIP2	1.75e-04	199	37	4	M8103
Coexpression	GSE41978_KLRG1_HIGH_VS_LOW_EFFECTOR_CD8_TCELL_UP	DES NBN TMEM123 PRRC1	1.78e-04	200	37	4	M9551
Coexpression	GSE17721_12H_VS_24H_PAM3CSK4_BMDC_UP	ALCAM GTF3C5 PRRC1 NOL6	1.78e-04	200	37	4	M4117
Coexpression	KAECH_DAY8_EFF_VS_MEMORY_CD8_TCELL_UP	BRCA1 TOP2A PRRC1 KIF11	1.78e-04	200	37	4	M3027
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	OXCT1 BRCA1 TOP2A KIF11 NUP210	3.91e-07	181	37	5	e4dbc09f0210de465d8347969b301c22463a2b7d
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast-matrix_-_immature_4\|E18.5-samps / Age Group, Lineage, Cell class and subclass	RSPH14 BRCA1 TOP2A KIF11	4.08e-06	130	37	4	169d88bffd7cd813a484d809defa638ceaca4bcb
ToppCell	PND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ALCAM NPY2R ANK3 SLC4A5	1.26e-05	173	37	4	45808cf69122c16b9d2b5ffa06d15392c55954b7
ToppCell	PND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ALCAM NPY2R ANK3 SLC4A5	1.26e-05	173	37	4	7fa9dbcb258c3ab974490063951620e2def03db1
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DES TOP2A KIF11 NUP210	1.29e-05	174	37	4	7b2f35add804981c7d588a996bdbca6ec11a1ca5
ToppCell	PND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ALCAM NPY2R TOP2A KIF11	1.38e-05	177	37	4	a68c3688f12aee22f3cb4049c4bccacbacb0fae6
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BRCA1 TOP2A KIF11 NUP210	1.44e-05	179	37	4	80112c686a8f85ad5e3cda6e3f3d3d51cf688092
ToppCell	facs-Aorta-Heart-3m-Myeloid-macrophage\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALCAM TOP2A KIF11 NUP210	1.54e-05	182	37	4	df26388c0c46d1c4775103c8e802937b4d4e7470
ToppCell	facs-Aorta-Heart-3m-Myeloid-leukocyte\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALCAM TOP2A KIF11 NUP210	1.57e-05	183	37	4	062ec08d66c923f90fee771b1bf8d98bdc7e6c1b
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_B-GC_B_(I)\|lymph-node_spleen / Manually curated celltypes from each tissue	BRCA1 KANK2 TOP2A KIF11	1.61e-05	184	37	4	057c6c2f570914fa4af84682589a86b61547d6c9
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	ALCAM ANK3 SLC4A5 DOCK9	1.64e-05	185	37	4	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	droplet-Lung-nan-21m-Lymphocytic-Proliferating_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OXCT1 BRCA1 TOP2A KIF11	1.75e-05	188	37	4	61ae7405ab56570409bf35382dc0a038e4137c15
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BRCA1 TOP2A DOCK9 KIF11	1.82e-05	190	37	4	31de1727822e9818652946dfb962daee77ffad68
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-Proliferating_T_cell-proliferating_T\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	OXCT1 BRCA1 TOP2A KIF11	1.86e-05	191	37	4	15dbc5a03bfab8931c0fd385b0f25874736ae874
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD4/8-lo-Cycling_T\|GI_small-bowel / Manually curated celltypes from each tissue	BRCA1 KANK2 TOP2A KIF11	1.86e-05	191	37	4	e642fa7395c05fb53324c9d46bbc52f89fc9673f
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DES ALCAM ANK3 KANK2	1.86e-05	191	37	4	b133ee1c0e58d00ddd2e4e05b01fd04947524c18
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-Proliferating_T_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	OXCT1 BRCA1 TOP2A KIF11	1.86e-05	191	37	4	45c15f5ce4a207ac944bed65d45f06c1657d1a6d
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BIN2 BRCA1 TOP2A KIF11	1.98e-05	194	37	4	6cc689595a182fbf685fa2f3b9c300f7170fb81f
ToppCell	wk_15-18-Hematologic_Lymphocytic-NK-Cycling_NK\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	BIN2 TOP2A KIF11 NUP210	1.98e-05	194	37	4	af08047e5728ee8198d2686af6a774f2acfa58ba
ToppCell	COVID-19-T_cells-Cycling_NK/T_cells\|COVID-19 / group, cell type (main and fine annotations)	BRCA1 TOP2A KIF11 NUP210	2.02e-05	195	37	4	764ed100c28d9bc93ee5ecabc5291c8f184d78da
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_B-GC_B_(I)\|lymph-node_spleen / Manually curated celltypes from each tissue	BRCA1 KANK2 TOP2A KIF11	2.06e-05	196	37	4	32d54c0b487f00c4f8bd765462e484da8a6625c9
ToppCell	BAL-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	OXCT1 BRCA1 TOP2A KIF11	2.10e-05	197	37	4	434a5686a103bb766e0d80038413f0e12ea3981a
ToppCell	Mild_COVID-19-T/NK-proliferating_T/NK\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	OXCT1 BRCA1 TOP2A KIF11	2.10e-05	197	37	4	5fd52fba2cb6fa67377f873da2ff6ce9c83b0591
ToppCell	Mild-Lymphoid-T-Proliferating_T\|Mild / Condition, Lineage, Cell class and cell subclass	OXCT1 BRCA1 TOP2A KIF11	2.10e-05	197	37	4	794517c70089da109f4c6489fe406c0ba6882b76
ToppCell	BAL-Mild-Lymphocyte-T/NK-Other_T\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	OXCT1 BRCA1 TOP2A KIF11	2.10e-05	197	37	4	6bddfa199ca812d9e518eaa02c3d4fb67e9f5b16
ToppCell	BAL-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	OXCT1 BRCA1 TOP2A KIF11	2.10e-05	197	37	4	c0a71a9452febda433bc544e4ac0a79c43dcf13e
ToppCell	BAL-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	OXCT1 BRCA1 TOP2A KIF11	2.10e-05	197	37	4	f34b1e34f1f0694564031077172c890b233ce8b7
ToppCell	BAL-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	OXCT1 BRCA1 TOP2A KIF11	2.10e-05	197	37	4	d7a9296092153cf66426911fecd810f0c1ef978e
ToppCell	BAL-Mild-Lymphocyte-T/NK-Other_T\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	OXCT1 BRCA1 TOP2A KIF11	2.10e-05	197	37	4	dcff23240bb7cb652d7426b29355aa74442ef6fc
ToppCell	Non-neuronal-Dividing-Radial_Glia-vRG-11\|World / Primary Cells by Cluster	TMEM123 BRCA1 TOP2A KIF11	2.14e-05	198	37	4	672c6faeed54e1397e12c0aac1a5cbd19c684f06
ToppCell	Leuk-UTI-Lymphocyte-T_NK-T_NK_proliferative\|Leuk-UTI / Disease, Lineage and Cell Type	OXCT1 BRCA1 TOP2A KIF11	2.19e-05	199	37	4	87113d398585076ece86b9098781e817f8ca241b
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Proliferating-Cycling_IN_Progenitors\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	TMEM123 BRCA1 TOP2A KIF11	2.19e-05	199	37	4	f315ec3fb6c0799668c9195f836a77fc0db2b615
ToppCell	Biopsy_Control_(H.)-Epithelial-Proliferating_Epithelial_cells\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	BRCA1 KANK2 TOP2A KIF11	2.19e-05	199	37	4	4fcf5bec207e4384fd73c5e8801a7e414e3ee7b0
ToppCell	COVID-19-Lymphoid-Proliferating_CD4_T_cells\|COVID-19 / Condition, Lineage and Cell class	OXCT1 BRCA1 TOP2A KIF11	2.19e-05	199	37	4	e1dfc856a85a91e8f7ab8d600a8a891d16b2aefb
ToppCell	Transverse-B_cell-B_cell_cycling\|B_cell / Region, Cell class and subclass	BRCA1 KANK2 TOP2A KIF11	2.19e-05	199	37	4	170ae68963d31f3b821b6f0e8f0c039bea0bc981
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Stem_cells-Neuroepithelial_cell\|10w / Sample Type, Dataset, Time_group, and Cell type.	TMEM123 BRCA1 TOP2A KIF11	2.23e-05	200	37	4	8f8b8c225cdc79baf16fe04be89bdb65e404a055
ToppCell	BAL-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	OXCT1 BRCA1 TOP2A KIF11	2.23e-05	200	37	4	60d11275f06490f86f400a2802492f9c1b570400
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Stem_cells\|10w / Sample Type, Dataset, Time_group, and Cell type.	TMEM123 BRCA1 TOP2A KIF11	2.23e-05	200	37	4	a1f48eca9efb4f3ec3c9ace20f8c9257dd72c4ed
ToppCell	COVID_non-vent-Lymphocytic-Proliferative_Lymphocyte-\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	OXCT1 BRCA1 TOP2A KIF11	2.23e-05	200	37	4	04bf9e6a0fbd792b49eed63dabba5d6fafed8c07
ToppCell	BAL-Severe-Lymphocyte-T/NK-Other_T\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	OXCT1 BRCA1 TOP2A KIF11	2.23e-05	200	37	4	535f6fba8d03873ba35c9949579161dc41cd7a60
ToppCell	Severe_COVID-19-T/NK-proliferating_T/NK\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	OXCT1 BRCA1 TOP2A KIF11	2.23e-05	200	37	4	52265e761a961f3724b388285e0919bd58847138
ToppCell	MS-IIF-Lymphocyte-T/NK-T/NK_proliferative\|IIF / Disease, condition lineage and cell class	OXCT1 BRCA1 TOP2A KIF11	2.23e-05	200	37	4	c7c1806a1054b2b034a26a18aac93fc3bec4dbc8
ToppCell	BAL-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	OXCT1 BRCA1 TOP2A KIF11	2.23e-05	200	37	4	dd7ad295ab3ba4c19babffb1625900db414bb5a9
ToppCell	Control-Control-Myeloid-immature_Neutrophil\|Control / Disease, condition lineage and cell class	ALCAM ATP2C1 TOP2A KIF11	2.23e-05	200	37	4	118321ac443feb42aee171baccfc4610f00a8822
ToppCell	Non-neuronal-Dividing-Radial_Glia-vRG\|World / Primary Cells by Cluster	TMEM123 BRCA1 TOP2A KIF11	2.23e-05	200	37	4	7596143925cd403ec7baceef87d19d570e48586a
ToppCell	BAL-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	OXCT1 BRCA1 TOP2A KIF11	2.23e-05	200	37	4	0e44a55d65b72eb40543d3bde301f8598ac251c3
ToppCell	COVID_non-vent-Lymphocytic-Proliferative_Lymphocyte\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	OXCT1 BRCA1 TOP2A KIF11	2.23e-05	200	37	4	f6b5320cdfe640a71e6e2df26f30d42e64b1c921
ToppCell	COVID-19-Lymphoid-Proliferating_CD8_T_cells\|COVID-19 / Condition, Lineage and Cell class	OXCT1 BRCA1 TOP2A KIF11	2.23e-05	200	37	4	b239c711cce967826432fdbd5f88eba98a88bb0c
ToppCell	BAL-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	OXCT1 BRCA1 TOP2A KIF11	2.23e-05	200	37	4	3c3ac587ad98e3f6be809eac18c7742a23140de1
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-T/NK-T/NK_proliferative\|ICU-NoSEP / Disease, condition lineage and cell class	OXCT1 BRCA1 TOP2A KIF11	2.23e-05	200	37	4	f70cc9198339eab7fbc68f5d9b75dfb28c9afc89
ToppCell	(3)_MNP-(3)_DC_Monocyte_Dividing\|(3)_MNP / Lung cell shreds - cell class (v4) and cell subclass (v4)	OXCT1 BRCA1 TOP2A KIF11	2.23e-05	200	37	4	d94fe9bd6ee7c1fed14666f24de41bda014e299b
ToppCell	Sepsis-Int-URO-Lymphocyte-T/NK-T/NK_proliferative\|Int-URO / Disease, condition lineage and cell class	OXCT1 BRCA1 TOP2A KIF11	2.23e-05	200	37	4	99acc1ea01288efdd5b166aa20d66735f2bbe543
ToppCell	Sepsis-Leuk-UTI-Lymphocyte-T/NK-T/NK_proliferative\|Leuk-UTI / Disease, condition lineage and cell class	OXCT1 BRCA1 TOP2A KIF11	2.23e-05	200	37	4	093e97395be23092229521cc55aaaee8befbc149
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DES ALCAM ANK3 KANK2	2.23e-05	200	37	4	c596a53c0b63c9deaac7d99fcbdd94ecfa96b86c
ToppCell	BAL-Severe-Lymphocyte-T/NK-Other_T\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	OXCT1 BRCA1 TOP2A KIF11	2.23e-05	200	37	4	5c84aaedac9f27da0da0493dab7c8f7a4d66888c
ToppCell	COVID-19_Mild-immature_Neutrophil-\|COVID-19_Mild / Disease condition and Cell class	NPY2R TOP2A KIF11	1.45e-04	123	37	3	5f19b0e32509bedeb9ac6c74ac7a20750798da5e
ToppCell	COVID-19_Mild-immature_Neutrophil\|COVID-19_Mild / Disease condition and Cell class	NPY2R TOP2A KIF11	1.45e-04	123	37	3	a6670825fd8d9f9a0111a7b68598c764c99abb0d
ToppCell	LPS-antiTNF-Unknown\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RSPH14 TOP2A KIF11	1.67e-04	129	37	3	739b263296c28554967362060b154f7a95e1341d
ToppCell	LPS-antiTNF-Unknown-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RSPH14 TOP2A KIF11	1.70e-04	130	37	3	615c233c7c2600c1c2bc5cf5b1c501fc474564ef
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	DES RSPH14 OXCT1	1.86e-04	134	37	3	72d7eec3aeb43319f3ef81bb5518fae8d8880136
ToppCell	Severe-B_intermediate-14\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	CASS4 ANK3 SLC4A5	2.21e-04	142	37	3	f9cbc266fcea19bec504be4f3a28d1173c6b2e3c
ToppCell	Severe-B_intermediate-14\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	CASS4 ANK3 SLC4A5	2.21e-04	142	37	3	9c7d5783302974b883bd887f997d094eb5925ec2
ToppCell	PND01-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BRCA1 TOP2A KIF11	2.21e-04	142	37	3	be63c48794a227ea55978524c0f5935342fc455e
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-Tfh\|Liver / Manually curated celltypes from each tissue	SIAE ANK3 DOCK9	2.91e-04	156	37	3	85bc34ff507f9a66c6e3ba7a3ffd5416d0073ccf
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BRCA1 TOP2A KIF11	2.91e-04	156	37	3	955547dfeb1b1ad4957b4338701055726b22619f
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZIC4 ANK3 OR56B1	2.91e-04	156	37	3	a4b0e89255ea5d60198cb2b3e739981f9c9cf5c5
ToppCell	droplet-Heart-nan-18m-Hematologic-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CASS4 TOP2A NUP210	3.25e-04	162	37	3	7f425a3983325a5a3ea33f812b15aa010cc55de0
ToppCell	LPS-antiTNF-Endothelial-Endothelial-FOXM1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BRCA1 TOP2A KIF11	3.31e-04	163	37	3	5285318c52aa31c9b22dc2ffff078e32e408604d
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BIN2 TOP2A KIF11	3.37e-04	164	37	3	ae09e5aabd1347b865474255e7411c04f63efb3b
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Lymphocytic-T_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZIC4 CACNA2D4 NUP210	3.37e-04	164	37	3	1a9b444d2c6abcc83d4355ec5228b27541df2bd0
ToppCell	367C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	BRCA1 TOP2A KIF11	3.37e-04	164	37	3	fb18b863152fb3109e2224c791c84c6371680a4e
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BRCA1 TOP2A KIF11	3.49e-04	166	37	3	2642544070564debe2deb2938d2c33997bf5ef02
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BRCA1 TOP2A KIF11	3.56e-04	167	37	3	50c29ea660bf07b890e4ac1a1985d0761d863dee
ToppCell	343B-Myeloid-Dendritic-cDC_proliferating_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	OXCT1 TOP2A KIF11	3.56e-04	167	37	3	3461d14e36f09ddc6ee5549ca4797e16d3f37fcc
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BRCA1 TOP2A KIF11	3.62e-04	168	37	3	d35944fd9fea9934ce1e76b2b35d48e2300cca61
ToppCell	PND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TOP2A MROH2A KIF11	3.62e-04	168	37	3	a7eb28e15b591997f1aee09501cb20ae18beca08
ToppCell	PND10-Immune-Immune_Myeloid-DC-cDC2-cDC2_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RSPH14 TOP2A KIF11	3.62e-04	168	37	3	4c402a1613fcf0a6e4d9b9d5551812940e91ff32
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BRCA1 TOP2A KIF11	3.68e-04	169	37	3	b253a4a50c06d36228fcd5d856c57202cbac158f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BRCA1 TOP2A KIF11	3.68e-04	169	37	3	0bc8ef341ce307b19018d4ac8de0a4d04254209d
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BRCA1 TOP2A KIF11	3.68e-04	169	37	3	563c267edaade0e5df192ad953801ef9768d4270
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BRCA1 TOP2A KIF11	3.68e-04	169	37	3	e7514956b2e4298222ec443f98b2f5289451786e
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TGFBR1 BRCA1 TOP2A	3.68e-04	169	37	3	a1efc20e34a81ae32f8d278a5486811ade03ef24
ToppCell	P07-Epithelial-epithelial_progenitor_cell-epi_progenitor\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ALCAM NPY2R ANK3	3.68e-04	169	37	3	1a47a4892a5e6a69555f5332308503526e5422a7
ToppCell	PND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BIN2 TOP2A KIF11	3.75e-04	170	37	3	da4dde7d0491ccc298cec7474a6a76ff3db36a4c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BIN2 TOP2A KIF11	3.81e-04	171	37	3	55c7bf7211587fa08df13c0a4ff5b78a85d5439e
ToppCell	PND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BIN2 TOP2A KIF11	3.81e-04	171	37	3	846a9acfff0bf0a9baf65dc07b7d7a9217ed6598
ToppCell	356C-Myeloid-Dendritic-cDC_proliferating_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ANK3 TOP2A KIF11	3.81e-04	171	37	3	b113fbebb89056af0b9c775d2fb6552206a80467
ToppCell	367C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|367C / Donor, Lineage, Cell class and subclass (all cells)	BRCA1 TOP2A KIF11	3.88e-04	172	37	3	8d20eda599abf1e9e3e3b90f314acddee6a465a4
ToppCell	390C-Myeloid-Dendritic-cDC_proliferating_1\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	BRCA1 TOP2A KIF11	3.88e-04	172	37	3	6fcc16f1067672967ecbcdfdc727649ae9891dd9
ToppCell	droplet-Lung-nan-18m-Lymphocytic-Proliferating_NK\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TOP2A KIF11 NUP210	3.88e-04	172	37	3	e495efd25aec60b97ac2b5aa861651bd73174a17
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BRCA1 TOP2A KIF11	3.94e-04	173	37	3	a25459b8140b0dbcb73e3b4cc1407b679229f25c
ToppCell	facs-Aorta-Heart-3m-Myeloid\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TOP2A KIF11 NUP210	3.94e-04	173	37	3	513b4d31bcfb269556c6b4cc389865fb12e52c4f
ToppCell	10x5'-Lung-Lymphocytic_NK-Cycling_NK\|Lung / Manually curated celltypes from each tissue	BRCA1 TOP2A KIF11	3.94e-04	173	37	3	d815832f89f70662706620e3b03ebb1dabec0034
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BRCA1 TOP2A KIF11	4.01e-04	174	37	3	84da9faff088d05233183b425385beb054c92d1b
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BRCA1 TOP2A KIF11	4.01e-04	174	37	3	c988471207ba06195bc3e41056435e8c31c20bbe
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4/8-lo-Cycling_T\|GI_small-bowel / Manually curated celltypes from each tissue	BRCA1 TOP2A KIF11	4.01e-04	174	37	3	e4c8da80eca07e4396f57dad212f76c2eca4c1bd
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BRCA1 TOP2A KIF11	4.01e-04	174	37	3	c26eac176e9b0cba385630fdc60e0314a4e4caac
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BRCA1 TOP2A KIF11	4.01e-04	174	37	3	dbb4e1a6c3319ce40f81bfd2d1745a88a2cc412e
ToppCell	droplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BRCA1 TOP2A KIF11	4.08e-04	175	37	3	a6913f992a1ea20b43e5adeca3ede3a6fda820ad
ToppCell	wk_20-22-Hematologic-Myeloid-Promonocyte-like\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	TOP2A KIF11 NUP210	4.08e-04	175	37	3	654299df246debe0a5b12f0d9568eb828bb94bb9
Disease	plasma beta-amyloid 1-42 measurement	ANK3 PRRC1	1.12e-04	13	36	2	EFO_0005660
Disease	Hereditary Breast and Ovarian Cancer Syndrome	NBN BRCA1	1.30e-04	14	36	2	C0677776
Disease	Breast Cancer, Familial	NBN BRCA1	6.16e-04	30	36	2	C0346153
Disease	Mammary Carcinoma, Animal	DES ALCAM BRCA1	6.93e-04	142	36	3	C1257925
Disease	Animal Mammary Neoplasms	DES ALCAM BRCA1	6.93e-04	142	36	3	C0024667
Disease	Mammary Neoplasms, Experimental	DES ALCAM BRCA1	8.94e-04	155	36	3	C0024668
Disease	Carcinomatosis	DES ALCAM BRCA1	1.03e-03	163	36	3	C0205699
Disease	Carcinoma, Spindle-Cell	DES ALCAM BRCA1	1.03e-03	163	36	3	C0205697
Disease	Undifferentiated carcinoma	DES ALCAM BRCA1	1.03e-03	163	36	3	C0205698
Disease	Anaplastic carcinoma	DES ALCAM BRCA1	1.03e-03	163	36	3	C0205696
Disease	Carcinoma	DES ALCAM BRCA1	1.05e-03	164	36	3	C0007097

Protein segments in the cluster

Peptide	Gene	Start	Entry
KETVMALQHKVVSSV	CASS4	441	Q9NQ75
VKVMHESSKRVSETL	BIN2	71	Q9UBW5
KTGTLTKNEMTVTHI	ATP2C1	351	P98194
VIHVVIKFKSMRTVT	NPY2R	71	P49146
SHLVATVTVKGVMTT	NUP210	491	Q8TEM1
VTNTEHAKRKTVTAM	H4C7	71	Q99525
HSVFSVTIHMKETTI	KIF11	236	P52732
ISATIHMQVVRKTTS	KCNJ11	211	Q14654
VVFLVSTRKIHTTMS	NOL6	356	Q9H6R4
VISVTHLTEMKATLI	OR56B1	266	Q8NGI3
VLQSHISDTSVVVKM	KRT87P	81	A6NCN2
VSTTELQKTTGTMIH	PARP4	1111	Q9UKK3
SSVTITTTMHSEAKK	TMEM123	146	Q8N131
LTNLITEETTHVVMK	BRCA1	1676	P38398
TVHEELTKSMTTILK	DOCK9	931	Q9BZ29
RMTIAKHTITTILDT	CACNA2D4	306	Q7Z3S7
HTKKTVMIKTIETRD	DES	441	P17661
KGMRVKEETHITTTT	ANK3	2236	Q12955
MVRSSTITVSDKAHI	INPP5B	301	P32019
TSNVHMVKKISITER	KANK2	396	Q63ZY3
TIIIETMSHKHSKCI	GALC	381	P54803
IDKKSMIASTAITVH	ALCAM	316	Q13740
HKVTMDTVKIITSSV	MROH2A	501	A6NES4
KMKVTVTQITVALSS	TMEM161B	431	Q8NDZ6
ECTHLVMVSVKVTIK	NBN	146	O60934
KIDISAVMSVHSAVK	PWWP3B	211	Q5H9M0
ETIMKKVTSVKAHSD	SIAE	66	Q9HAT2
VKSVLDKTKHSVESM	PRRC1	226	Q96M27
SSAKTKVVVTMEHSA	OXCT1	431	P55809
VSVTETTDKVIHNSM	TGFBR1	56	P36897
TVTGKSSEHKVMEVT	NUFIP2	521	Q7Z417
SMVRIKTTEVLHITA	RSPH14	81	Q9UHP6
TVISIAHIDSLKMET	SLC4A5	896	Q9BY07
KTFSTMHELVTHVTV	ZIC4	146	Q8N9L1
HTDTTVKFVVKMTEE	TOP2A	961	P11388
ITVKKTSSQLVTMHD	GTF3C5	351	Q9Y5Q8
LETITMHKILETTTF	UGGT1	651	Q9NYU2