Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cell-cell adhesion mediator activity	ROBO4 DSCAM NFASC SIRPA DSCAML1 PKP2	1.31e-05	61	170	6	GO:0098632
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	DENND4A DOCK10 ARFGEF1 EPS8L1 DENND4C RIC8B ARHGEF4 MCF2L RINL GDPGP1	2.99e-05	231	170	10	GO:0005085
GeneOntologyMolecularFunction	cell adhesion mediator activity	ROBO4 DSCAM NFASC SIRPA DSCAML1 PKP2	4.66e-05	76	170	6	GO:0098631
GeneOntologyMolecularFunction	enzyme regulator activity	COL6A3 DENND4A KDM5A DOCK10 ARFGEF1 CASP9 NLRP1 TBC1D22B EPS8L1 SIRPA ADGRV1 SSPOP DENND4C B3GAT3 RIC8B RPTOR PHACTR4 AHSG ARHGEF4 MCF2L RINL PZP GDPGP1 ARHGAP33 PPP6R3	4.12e-04	1418	170	25	GO:0030234
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	DENND4A DOCK10 ARFGEF1 TBC1D22B EPS8L1 SIRPA DENND4C RIC8B ARHGEF4 MCF2L RINL GDPGP1 ARHGAP33	4.15e-04	507	170	13	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	DENND4A DOCK10 ARFGEF1 TBC1D22B EPS8L1 SIRPA DENND4C RIC8B ARHGEF4 MCF2L RINL GDPGP1 ARHGAP33	4.15e-04	507	170	13	GO:0030695
GeneOntologyMolecularFunction	phosphatase binding	SIRPA PPP1R3G SH2D4A IKBKE PHACTR4 DLG3 CDC5L MAP2K7 PPP6R3	4.47e-04	264	170	9	GO:0019902
GeneOntologyMolecularFunction	protein phosphatase binding	SIRPA PPP1R3G IKBKE PHACTR4 DLG3 CDC5L MAP2K7 PPP6R3	4.48e-04	210	170	8	GO:0019903
GeneOntologyMolecularFunction	protein binding involved in heterotypic cell-cell adhesion	NFASC SIRPA PKP2	4.50e-04	18	170	3	GO:0086080
GeneOntologyBiologicalProcess	maintenance of animal organ identity	ADGRV1 PKP2 USH2A	5.06e-06	5	166	3	GO:0048496
GeneOntologyCellularComponent	stereocilium	ADGRV1 PTPRQ PCDH15 MYO15A USH2A	2.61e-04	69	172	5	GO:0032420
GeneOntologyCellularComponent	USH2 complex	ADGRV1 USH2A	4.00e-04	4	172	2	GO:1990696
GeneOntologyCellularComponent	stereocilium bundle	ADGRV1 PTPRQ PCDH15 MYO15A USH2A	4.91e-04	79	172	5	GO:0032421
GeneOntologyCellularComponent	stereocilia ankle link	ADGRV1 USH2A	9.88e-04	6	172	2	GO:0002141
GeneOntologyCellularComponent	stereocilia ankle link complex	ADGRV1 USH2A	9.88e-04	6	172	2	GO:0002142
GeneOntologyCellularComponent	TORC1 complex	MTOR RPTOR	9.88e-04	6	172	2	GO:0031931
GeneOntologyCellularComponent	stereocilium membrane	ADGRV1 USH2A	9.88e-04	6	172	2	GO:0060171
GeneOntologyCellularComponent	periciliary membrane compartment	ADGRV1 USH2A	9.88e-04	6	172	2	GO:1990075
Domain	LRRC37AB_C	LRRC37A3 LRRC37A2 LRRC37A LRRC37B	6.79e-09	4	171	4	IPR029423
Domain	LRRC37AB_C	LRRC37A3 LRRC37A2 LRRC37A LRRC37B	6.79e-09	4	171	4	PF14914
Domain	LRRC37_N	LRRC37A3 LRRC37A2 LRRC37A LRRC37B	6.79e-09	4	171	4	IPR032754
Domain	LRRC37	LRRC37A3 LRRC37A2 LRRC37A LRRC37B	6.79e-09	4	171	4	PF15779
Domain	LRRC37A/B-like	LRRC37A3 LRRC37A2 LRRC37A LRRC37B	6.79e-09	4	171	4	IPR015753
Domain	FN3_dom	ROBO4 IL12RB2 COL6A3 DSCAM NFASC DSCAML1 IFNLR1 KIAA0319 USH2A MYBPC3	2.34e-05	209	171	10	IPR003961
Domain	FN3	ROBO4 IL12RB2 COL6A3 DSCAM NFASC DSCAML1 KIAA0319 USH2A MYBPC3	5.30e-05	185	171	9	SM00060
Domain	FN3	ROBO4 IL12RB2 COL6A3 DSCAM NFASC DSCAML1 IFNLR1 USH2A MYBPC3	9.30e-05	199	171	9	PS50853
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KCTD12 FRAS1 ABL1 KMT2B CTC1 RPS6KA2 UBR4 LAMA5 CC2D1A REV3L POM121C ABCA7 IFNLR1 TFE3 DHX30 C2CD3 SCAP MTOR RPTOR PKD1 POLL ARHGEF4 MAPKBP1 MCF2L ZNF839 CHPF CRAMP1 ARHGAP33	2.68e-12	1105	177	28	35748872
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DENND4A ABL1 KDM5A RPS6KA2 BRSK2 CC2D1A TBC1D22B RFX7 ATAT1 DENND4C FSIP2 C2CD3 IKBKE MTOR PRRC2C RPTOR PHACTR4 PKP2 ARHGEF4 CRYBG3 CAMSAP2 MAP2K7	6.17e-10	861	177	22	36931259
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	KCTD12 DSCAM KDM5A FXR2 RPS6KA2 UBR4 NFASC SIRPA KIAA0319 FAM120A DNAJA4 MTOR PRRC2C RPTOR BRD7 DCHS1 CCAR1 DLG3 CDC5L CAMSAP2	1.18e-07	963	177	20	28671696
Pubmed	Evolutionary dynamism of the primate LRRC37 gene family.	LRRC37A3 LRRC37A2 LRRC37A LRRC37B	1.33e-07	10	177	4	23064749
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	UBR2 FRAS1 DOCK10 GON4L MAP3K4 DHX30 KIAA0319 PRRC2C DLG3 ARHGEF4 MAPKBP1 MCF2L CAMSAP2	1.93e-07	407	177	13	12693553
Pubmed	Usher syndromes due to MYO7A, PCDH15, USH2A or GPR98 mutations share retinal disease mechanism.	ADGRV1 PCDH15 USH2A	5.16e-07	4	177	3	18463160
Pubmed	Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.	LRRC37A3 LRRC37A2 LRRC37A	5.16e-07	4	177	3	22419166
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	LRRC37A3 ERAP1 MARCHF6 LAMA5 SSPOP LRRC37A MAPKBP1	1.17e-06	105	177	7	9628581
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	IL12RB2 KDM5A FXR2 AHCTF1 GPT PEX1 REV3L POM121C ABCA7 NAA35 FAM120A ZFHX4 RPTOR BRD7 PKP2 CRYBG3 WDR13 MAP2K7 PHIP ARHGAP33	1.19e-06	1116	177	20	31753913
Pubmed	Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2.	ADGRV1 PCDH15 USH2A	1.29e-06	5	177	3	16301216
Pubmed	A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.	KCNH7 ERAP1 REV3L IFNLR1	2.37e-06	19	177	4	20953190
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	ERAP1 DOCK10 NFASC ADGRV1 DSCAML1 SCAP GRIP2 ARHGEF4 CDC5L	2.52e-06	225	177	9	12168954
Pubmed	Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF-mediated myelopoiesis.	SCAP MTOR RPTOR	2.56e-06	6	177	3	28784627
Pubmed	TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling.	OTUD7B MTOR RPTOR	4.47e-06	7	177	3	28489822
Pubmed	Biochemical characterization of native Usher protein complexes from a vesicular subfraction of tracheal epithelial cells.	ADGRV1 PCDH15 USH2A	4.47e-06	7	177	3	20058854
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	FRAS1 DENND4A DOCK10 PEX1 GON4L RAD54L2 URGCP FAM120A MOGS PRRC2C CHTF18 CCAR1 CRYBG3 PZP	6.78e-06	650	177	14	38777146
Pubmed	Microarray-based mutation analysis of 183 Spanish families with Usher syndrome.	ADGRV1 PCDH15 USH2A	7.12e-06	8	177	3	19683999
Pubmed	Fras1 deficiency results in cryptophthalmos, renal agenesis and blebbed phenotype in mice.	COL6A3 FRAS1 LAMA5	7.12e-06	8	177	3	12766770
Pubmed	Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2.	PCDH15 MYO15A USH2A	1.06e-05	9	177	3	23144817
Pubmed	Genetic link between renal birth defects and congenital heart disease.	FRAS1 LAMA5 PKD1 CC2D2A	1.21e-05	28	177	4	27002738
Pubmed	Massively parallel DNA sequencing facilitates diagnosis of patients with Usher syndrome type 1.	ADGRV1 PCDH15 USH2A	1.51e-05	10	177	3	24618850
Pubmed	Usher protein functions in hair cells and photoreceptors.	ADGRV1 PCDH15 USH2A	1.51e-05	10	177	3	24239741
Pubmed	The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids.	MTOR RPTOR PPP6R3	1.51e-05	10	177	3	27244671
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MARCHF6 LAMA5 NFASC NUDCD3 ADGRV1 URGCP EFR3A TRANK1 RPTOR PLCH2 CRAMP1 PPP6R3	1.89e-05	529	177	12	14621295
Pubmed	The mTORC1 component RPTOR is required for maintenance of the foundational spermatogonial stem cell pool in mice†.	MTOR RPTOR	2.58e-05	2	177	2	30202948
Pubmed	Regulation of mTOR by polycystin-1: is polycystic kidney disease a case of futile repair?	MTOR PKD1	2.58e-05	2	177	2	17102641
Pubmed	Partial USH2A deletions contribute to Usher syndrome in Denmark.	PCDH15 USH2A	2.58e-05	2	177	2	25804404
Pubmed	The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris.	TFE3 MTOR	2.58e-05	2	177	2	24448649
Pubmed	The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells.	PCDH15 MYO15A	2.58e-05	2	177	2	24940003
Pubmed	Human down syndrome cell adhesion molecules (DSCAMs) are functionally conserved with Drosophila Dscam[TM1] isoforms in controlling neurodevelopment.	DSCAM DSCAML1	2.58e-05	2	177	2	21645617
Pubmed	Mutational screening of the TPO and DUOX2 genes in Argentinian children with congenital hypothyroidism due to thyroid dyshormonogenesis.	TPO DUOX2	2.58e-05	2	177	2	35507000
Pubmed	Hepatic overexpression of a dominant negative form of raptor enhances Akt phosphorylation and restores insulin sensitivity in K/KAy mice.	MTOR RPTOR	2.58e-05	2	177	2	18270303
Pubmed	TFE3 fusions escape from controlling of mTOR signaling pathway and accumulate in the nucleus promoting genes expression in Xp11.2 translocation renal cell carcinomas.	TFE3 MTOR	2.58e-05	2	177	2	30849994
Pubmed	Deletion of mTORC1 Activity in CD4+ T Cells Is Associated with Lung Fibrosis and Increased γδ T Cells.	MTOR RPTOR	2.58e-05	2	177	2	27649073
Pubmed	mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors.	MTOR RPTOR	2.58e-05	2	177	2	29786082
Pubmed	Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning.	MTOR RPTOR	2.58e-05	2	177	2	27018708
Pubmed	The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity.	MTOR RPTOR	2.58e-05	2	177	2	16847060
Pubmed	Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism.	ZC3H12A MTOR	2.58e-05	2	177	2	30297433
Pubmed	Disease expression in Usher syndrome caused by VLGR1 gene mutation (USH2C) and comparison with USH2A phenotype.	ADGRV1 USH2A	2.58e-05	2	177	2	15671307
Pubmed	c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage.	ABL1 CASP9	2.58e-05	2	177	2	15657060
Pubmed	mTOR kinase-dependent, but raptor-independent regulation of downstream signaling is important for cell cycle exit and myogenic differentiation.	MTOR RPTOR	2.58e-05	2	177	2	25486193
Pubmed	Characteristics of Retinitis Pigmentosa Associated with ADGRV1 and Comparison with USH2A in Patients from a Multicentric Usher Syndrome Study Treatrush.	ADGRV1 USH2A	2.58e-05	2	177	2	34638692
Pubmed	Usher's Syndrome Type II: A Comparative Study of Genetic Mutations and Vestibular System Evaluation.	ADGRV1 USH2A	2.58e-05	2	177	2	28653555
Pubmed	mTOR intersects antibody-inducing signals from TACI in marginal zone B cells.	MTOR TNFRSF13B	2.58e-05	2	177	2	29133782
Pubmed	DSCAM and DSCAML1 regulate the radial migration and callosal projection in developing cerebral cortex.	DSCAM DSCAML1	2.58e-05	2	177	2	25451118
Pubmed	Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking.	MTOR RPTOR	2.58e-05	2	177	2	17301289
Pubmed	Positive association of CC2D1A and CC2D2A gene haplotypes with mental retardation in a Han Chinese population.	CC2D1A CC2D2A	2.58e-05	2	177	2	22023432
Pubmed	Hair bundle defects and loss of function in the vestibular end organs of mice lacking the receptor-like inositol lipid phosphatase PTPRQ.	ADGRV1 PTPRQ	2.58e-05	2	177	2	22357859
Pubmed	Mammalian DSCAMs: roles in the development of the spinal cord, cortex, and cerebellum?	DSCAM DSCAML1	2.58e-05	2	177	2	12051741
Pubmed	Conditional Knockout of Raptor/mTORC1 Results in Dentin Malformation.	MTOR RPTOR	2.58e-05	2	177	2	30984011
Pubmed	Hepatic peroxisomal β-oxidation suppresses lipophagy via RPTOR acetylation and MTOR activation.	MTOR RPTOR	2.58e-05	2	177	2	32687428
Pubmed	Mitotic raptor promotes mTORC1 activity, G(2)/M cell cycle progression, and internal ribosome entry site-mediated mRNA translation.	MTOR RPTOR	2.58e-05	2	177	2	20439490
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	KCTD12 UBR4 DHX30 NAA35 FAM120A PRRC2C KANK4 CDC5L MCF2L PZP PHIP	3.51e-05	475	177	11	31040226
Pubmed	A central role for regulated protein stability in the control of TFE3 and MITF by nutrients.	TFE3 MTOR RPTOR	4.53e-05	14	177	3	36608670
Pubmed	Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.	ADGRV1 PCDH15 MYO15A	4.53e-05	14	177	3	26754646
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	ROBO4 COL6A3 ICAM2 KERA SIRPA ECM1 AHSG PZP	5.54e-05	257	177	8	16335952
Pubmed	Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.	ADGRV1 PTPRQ USH2A	6.91e-05	16	177	3	17567809
Pubmed	Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.	LAMA5 ADGRV1 PTPRQ MYO15A	7.51e-05	44	177	4	27534441
Pubmed	Polycystin-1 affects cancer cell behaviour and interacts with mTOR and Jak signalling pathways in cancer cell lines.	MTOR PKD1	7.70e-05	3	177	2	31251475
Pubmed	Distribution and association of mTOR with its cofactors, raptor and rictor, in cumulus cells and oocytes during meiotic maturation in mice.	MTOR RPTOR	7.70e-05	3	177	2	23440873
Pubmed	Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges.	DENND4A DENND4C	7.70e-05	3	177	2	12906859
Pubmed	mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition.	MTOR RPTOR	7.70e-05	3	177	2	25385646
Pubmed	GPR43 activation enhances psoriasis-like inflammation through epidermal upregulation of IL-6 and dual oxidase 2 signaling in a murine model.	FFAR2 DUOX2	7.70e-05	3	177	2	28212864
Pubmed	mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity.	MTOR RPTOR	7.70e-05	3	177	2	28813526
Pubmed	Functional consequences of dual oxidase-thyroperoxidase interaction at the plasma membrane.	TPO DUOX2	7.70e-05	3	177	2	20826581
Pubmed	mTOR Signaling in Growth, Metabolism, and Disease.	MTOR RPTOR	7.70e-05	3	177	2	28283069
Pubmed	PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome.	ADGRV1 USH2A	7.70e-05	3	177	2	20440071
Pubmed	Interferon-gamma induces human vascular smooth muscle cell proliferation and intimal expansion by phosphatidylinositol 3-kinase dependent mammalian target of rapamycin raptor complex 1 activation.	MTOR RPTOR	7.70e-05	3	177	2	17656678
Pubmed	Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy.	MTOR RPTOR	7.70e-05	3	177	2	20008564
Pubmed	Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908.	MTOR RPTOR	7.70e-05	3	177	2	22356909
Pubmed	Myocardium of patients with dilated cardiomyopathy presents altered expression of genes involved in thyroid hormone biosynthesis.	TPO DUOX2	7.70e-05	3	177	2	29320567
Pubmed	The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis.	TFE3 MTOR	7.70e-05	3	177	2	22692423
Pubmed	mTORC1 directly phosphorylates and activates ERα upon estrogen stimulation.	MTOR RPTOR	7.70e-05	3	177	2	26522726
Pubmed	Genotypes and phenotypes of congenital goitre and hypothyroidism caused by mutations in dual oxidase 2 genes.	TPO DUOX2	7.70e-05	3	177	2	24735383
Pubmed	Leucine regulates autophagy via acetylation of the mTORC1 component raptor.	MTOR RPTOR	7.70e-05	3	177	2	32561715
Pubmed	Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation.	MTOR RPTOR	7.70e-05	3	177	2	19864431
Pubmed	Identification of Pathogenic Genes of Nonsyndromic Hearing Loss in Uyghur Families Using Massively Parallel DNA Sequencing Technique.	PCDH15 MYO15A	7.70e-05	3	177	2	29692870
Pubmed	Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells.	MTOR RPTOR	7.70e-05	3	177	2	24567410
Pubmed	mTOR has distinct functions in generating versus sustaining humoral immunity.	MTOR RPTOR	7.70e-05	3	177	2	27760048
Pubmed	Essential role of D1R in the regulation of mTOR complex1 signaling induced by cocaine.	MTOR RPTOR	7.70e-05	3	177	2	26314207
Pubmed	Genetic variations of mTORC1 genes and risk of gastric cancer in an Eastern Chinese population.	MTOR RPTOR	7.70e-05	3	177	2	23423739
Pubmed	Reduced juvenile long-term depression in tuberous sclerosis complex is mitigated in adults by compensatory recruitment of mGluR5 and Erk signaling.	MTOR RPTOR	7.70e-05	3	177	2	23966835
Pubmed	mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex.	MTOR PKD1	7.70e-05	3	177	2	26931735
Pubmed	Architecture of human mTOR complex 1.	MTOR RPTOR	7.70e-05	3	177	2	26678875
Pubmed	Replacing the PDZ-interacting C-termini of DSCAM and DSCAML1 with epitope tags causes different phenotypic severity in different cell populations.	DSCAM DSCAML1	7.70e-05	3	177	2	27637097
Pubmed	Regulated vesicular trafficking of specific PCDH15 and VLGR1 variants in auditory hair cells.	ADGRV1 PCDH15	7.70e-05	3	177	2	23035094
Pubmed	mTOR phosphorylated at S2448 binds to raptor and rictor.	MTOR RPTOR	7.70e-05	3	177	2	19145465
Pubmed	Non-USH2A mutations in USH2 patients.	ADGRV1 USH2A	7.70e-05	3	177	2	22147658
Pubmed	Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells.	MTOR RPTOR	7.70e-05	3	177	2	20233713
Pubmed	Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1.	MTOR RPTOR	7.70e-05	3	177	2	21471201
Pubmed	The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT1) in Regulation of mTOR.	MTOR RPTOR	7.70e-05	3	177	2	25657994
Pubmed	Expression of the mTOR pathway regulators in human pituitary adenomas indicates the clinical course.	MTOR RPTOR	7.70e-05	3	177	2	23898069
Pubmed	Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1.	MTOR RPTOR	7.70e-05	3	177	2	12912989
Pubmed	Localization of Rheb to the endomembrane is critical for its signaling function.	MTOR RPTOR	7.70e-05	3	177	2	16631613
Pubmed	Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function.	MTOR RPTOR	7.70e-05	3	177	2	22143799
Pubmed	Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility.	MTOR RPTOR	7.70e-05	3	177	2	19724909
Pubmed	Conditional Disruption of Raptor Reveals an Essential Role for mTORC1 in B Cell Development, Survival, and Metabolism.	MTOR RPTOR	7.70e-05	3	177	2	27521345
Pubmed	Stimulation of endothelin B receptors in astrocytes induces cAMP response element-binding protein phosphorylation and c-fos expression via multiple mitogen-activated protein kinase signaling pathways.	RPS6KA2 MAP2K7	7.70e-05	3	177	2	11698596
Pubmed	Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression.	PKD1 AHSG	7.70e-05	3	177	2	25888842
Pubmed	mTORC1 Signaling is a Critical Regulator of Postnatal Tendon Development.	MTOR RPTOR	7.70e-05	3	177	2	29215029
Interaction	TOP3B interactions	KCTD12 FRAS1 ABL1 KMT2B CTC1 FXR2 RPS6KA2 UBR4 LAMA5 CC2D1A REV3L POM121C ABCA7 IFNLR1 TFE3 DHX30 C2CD3 SCAP FAM120A MOGS MTOR RPTOR PKD1 AHSG PKP2 POLL ARHGEF4 MAPKBP1 MCF2L ZNF839 CHPF CRAMP1 DDX28 ARHGAP33	1.08e-07	1470	174	34	int:TOP3B
GeneFamily	Fibronectin type III domain containing	ROBO4 IL12RB2 DSCAM NFASC DSCAML1 PTPRQ USH2A MYBPC3	1.01e-05	160	118	8	555
GeneFamily	Fibronectin type III domain containing\|USH2 complex	ADGRV1 USH2A	2.51e-04	4	118	2	1244
GeneFamily	MTOR complex 1\|MTOR complex 2	MTOR RPTOR	2.51e-04	4	118	2	1332
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR2 UBR4	8.68e-04	7	118	2	785
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 ADGRV1 SSPOP DSCAML1 TRANK1 ZFHX4 NRK PTPRQ PCDH15 MYO15A USH2A	2.02e-10	184	176	11	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 ADGRV1 SSPOP DSCAML1 TRANK1 ZFHX4 NRK PTPRQ PCDH15 MYO15A USH2A	2.02e-10	184	176	11	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 ADGRV1 SSPOP DSCAML1 TRANK1 ZFHX4 NRK PTPRQ PCDH15 MYO15A USH2A	2.02e-10	184	176	11	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 ADGRV1 PTPRQ PCDH15 DMBT1 MYO15A USH2A	1.82e-06	145	176	7	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FRAS1 DUOX2 ADGRV1 PTPRQ PCDH15 DMBT1 USH2A	3.81e-06	162	176	7	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPO FRAS1 DSCAM ADGRV1 TRANK1 PCDH15 USH2A	5.03e-06	169	176	7	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ2 ABCA6 IKBKE KANK4 FKBPL PYCR3	5.86e-06	173	176	7	ab6d3507301038f944ad59ccd848b5e6eeb76d04
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CTC1 FFAR2 CASP9 EVPL SIRPA CHTF18 CRAMP1	6.81e-06	177	176	7	1d5a071157c755f3a27a5c3143015da04ee0b0dc
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A3 TSHZ2 KERA NFASC ZFHX4 ABCA6 NRK	8.17e-06	182	176	7	3dfa9187e9d2bab1d199079d29209c4648220ada
ToppCell	343B-Epithelial_cells-Epithelial-I_(AT1)\|343B / Donor, Lineage, Cell class and subclass (all cells)	DSCAM LAMA5 EVPL ABCA7 NRK KANK4 MSLN	8.77e-06	184	176	7	cb15d6bae52c5ec251c2235859dc7e65f630ae23
ToppCell	343B-Epithelial_cells-Epithelial-I_(AT1)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	DSCAM LAMA5 EVPL ABCA7 NRK KANK4 MSLN	8.77e-06	184	176	7	bde4eaabd3e9bdaed23867d23a919b9d84b52d4b
ToppCell	5'-Adult-LymphNode-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCTD12 ROBO4 RPS6KA2 ICAM2 LAMA5 TNS2 MCF2L	1.08e-05	190	176	7	141266bf411ea675fbf889b20c1b08673c45ff95
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TPO FRAS1 DUOX2 NRK PTPRQ USH2A PIWIL3	1.20e-05	193	176	7	315840bc48899f3a36d57b19197509de19716e3d
ToppCell	5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TPO ROBO4 TSHZ2 RPS6KA2 LAMA5 DCHS1 MCF2L	1.20e-05	193	176	7	c0973a2c97deb7176c2f617c8760a55f7edc9839
ToppCell	Entopeduncular-Macroglia-OLIGODENDROCYTE-O1-Trf\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	COL6A3 ADGRV1 SSPOP DNAH14 ABCA6	1.28e-05	76	176	5	efbbbf91bca35720d8ecddb076f2c9f4de25e44d
ToppCell	Entopeduncular-Macroglia-OLIGODENDROCYTE-O1\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	COL6A3 ADGRV1 SSPOP DNAH14 ABCA6	1.28e-05	76	176	5	254d18bece2676faa4bbeb8d48b1d327ab3c2215
ToppCell	COVID-19-kidney-Fibroblast-2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	COL6A3 TSHZ2 NFASC REV3L ZFPM2 ZFHX4 ABCA6	1.28e-05	195	176	7	3d62ce1c696f47d4d7eb0c5bb0eec2c24b122bb2
ToppCell	5'-Adult-Appendix-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TPO KCTD12 ROBO4 RPS6KA2 ICAM2 LAMA5 TNS2	1.37e-05	197	176	7	e8e879b7634a29569061d3515d180784094a31e7
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCTD12 TSHZ2 KERA ZFPM2 ZFHX4 ABCA6 NRK	1.37e-05	197	176	7	6b6440f1baad5680cf9e13ca3ab72a2c65523d59
ToppCell	5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TPO KCTD12 ROBO4 ICAM2 LAMA5 TNS2 MCF2L	1.46e-05	199	176	7	258d59cf811bf1668ffbb5f18f961021f660de62
ToppCell	E18.5-samps-Endothelial-Mature_fetal_endothelial-capillary_endothelial_Hpgd-CA4_high\|E18.5-samps / Age Group, Lineage, Cell class and subclass	ROBO4 IL12RB2 ICAM2 CC2D1A ECM1 HS3ST1	3.42e-05	154	176	6	212c340a096a3a9669d1aebd61c045cf1402a868
ToppCell	facs-Marrow-KLS-18m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSCAM TSHZ2 FAM78B ADGRV1 SSPOP EFR3A	3.42e-05	154	176	6	37765512dfae557b9f6eb30a29463b93682a4404
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ2 NFASC ECM1 ZFPM2 FKBPL	3.68e-05	156	176	6	d5207dbfbcfb885557ea1378dfe6a56d7102e94a
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ2 NFASC ECM1 ZFPM2 FKBPL	3.68e-05	156	176	6	363f1b661048d25895e2b8681c82894c957b29c0
ToppCell	Cerebellum-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Klk6_(Klk6)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	ADGRV1 ITGAD KCNU1 ABCA6 TNFRSF13B	3.97e-05	96	176	5	a48235df1f5526ce3ffc4c0c2ba038eb20229c55
ToppCell	Cerebellum-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Klk6_(Klk6)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	ADGRV1 ITGAD KCNU1 ABCA6 TNFRSF13B	3.97e-05	96	176	5	0fc179af7370a29b7bd5d81e1302a479ae72f196
ToppCell	Cerebellum-Macroglia-OLIGODENDROCYTE-O2-Trf\|Cerebellum / BrainAtlas - Mouse McCarroll V32	ADGRV1 ITGAD KCNU1 ABCA6 TNFRSF13B	3.97e-05	96	176	5	c301ecfd67ece8bb12be1b94b614957a58046457
ToppCell	Cerebellum-Macroglia-OLIGODENDROCYTE-O2\|Cerebellum / BrainAtlas - Mouse McCarroll V32	ADGRV1 ITGAD KCNU1 ABCA6 TNFRSF13B	3.97e-05	96	176	5	7d402d543ff159c9bb84c00b083e6e18fc0ff786
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 ADGRV1 DSCAML1 ZFHX4 PTPRQ USH2A	4.24e-05	160	176	6	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 ADGRV1 DSCAML1 ZFHX4 PTPRQ USH2A	4.24e-05	160	176	6	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	VE-CD8-CD4_Treg\|VE / Condition, Cell_class and T cell subcluster	RPS6KA2 EPS8L1 ADGRV1 POM121C ABCA7 PZP	4.39e-05	161	176	6	a114f4f75859d9ef900e5146686438d051241429
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ2 NFASC ZFPM2 ABCA6 PZP	4.70e-05	163	176	6	bbc078761c5043af13d9a6fcf3145a3e300bae5e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ2 NFASC ZFPM2 ABCA6 PZP	4.70e-05	163	176	6	8e32b6431e1862572663aa6ddc4ea299c6acc8a6
ToppCell	368C-Myeloid-Monocyte-CD16+_Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	NFASC TNS2 IFNLR1 TRANK1 DBNDD1 PCBP4	5.38e-05	167	176	6	dbd2b9f2f4ba7be5fdf8318094e6b078cb1d1c43
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A3 RPS6KA2 TNS2 REV3L ABCA6 CRYBG3	5.75e-05	169	176	6	c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-mesothelial_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GPT FCHO1 SH2D4A PTPRQ HS3ST1 MSLN	5.75e-05	169	176	6	0cece9b2bb1f58e465c20ec8735a4fc3c1021f03
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GPT FCHO1 SH2D4A PTPRQ HS3ST1 MSLN	5.75e-05	169	176	6	6937c46b119d4ce382fc8c2fa5925ede5ae89c81
ToppCell	368C-Myeloid-Monocyte-CD16+_Monocyte\|Monocyte / Donor, Lineage, Cell class and subclass (all cells)	NFASC TNS2 IFNLR1 TRANK1 DBNDD1 PCBP4	5.94e-05	170	176	6	4a19c7e3bb0f9c2601a10debe7000066789b4150
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 DENND4A RPS6KA2 ITGAD DENND4C MTOR	6.75e-05	174	176	6	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(RGS5+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FRAS1 LAMA5 EPS8L1 PKP2 MYO15A MSLN	6.97e-05	175	176	6	f5451c29c487b998778e50349b3d774d5e20fd28
ToppCell	AT1_cells-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	FRAS1 KDM5A LAMA5 EVPL DBNDD1 KANK4	7.19e-05	176	176	6	458720776b0151cd55acc352d509599cb62f0ca8
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDI2 PSPH ATAT1 MTOR CHTF18 PKP2	7.42e-05	177	176	6	c6812679aa6522d03bd29144e71c5fae6a92325e
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-Plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDI2 PSPH ATAT1 MTOR CHTF18 PKP2	7.42e-05	177	176	6	ff97398d2adb83063b7c53a264bfae86ea7ea304
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ2 NFASC ZFPM2 ZFHX4 ABCA6	7.66e-05	178	176	6	d4ecb84e9b1f4ec49c519321156aa10f9bd34cce
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KCTD12 KMT2B TBC1D22B NSDHL POLL DCBLD2	7.66e-05	178	176	6	c87945146b2734141f07b39d268e0d8086ee0364
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ2 NFASC ZFPM2 ZFHX4 ABCA6	7.66e-05	178	176	6	78a0c6340001a77f5b2d890b6263f574af2e72da
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DSCAM DOCK10 DSCAML1 SH2D4A GRIP2 CRYBG3	7.90e-05	179	176	6	e6ae070b4c52ba08167c7d64ea4cfbac0454c1bf
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_3\|356C / Donor, Lineage, Cell class and subclass (all cells)	DDI2 NAA35 MTOR TNFRSF13B POLL LRRC37B	7.90e-05	179	176	6	f378307eb20f002450c748b7be2289d6db2fcbcb
ToppCell	droplet-Heart-nan-3m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EVPL EPS8L1 SH2D4A ZFHX4 MTOR KANK4	8.14e-05	180	176	6	da723df348d7b8449bb1124f23fe6fa706412adb
ToppCell	droplet-Heart-nan-3m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EVPL EPS8L1 SH2D4A ZFHX4 MTOR KANK4	8.14e-05	180	176	6	5b146a94708b3c3610542a4d0925f3f7a2b19185
ToppCell	droplet-Heart-nan-3m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EVPL EPS8L1 SH2D4A ZFHX4 MTOR KANK4	8.14e-05	180	176	6	50758b1e7be2e43f83c10ab106900c067e61f5f7
ToppCell	E16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PDE7A ASAH2 FKBPL DLG3 DCBLD2 MSLN	8.39e-05	181	176	6	f6629fa71bb94405f523f63a9264cacf6d15c5f4
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-stromal_related-ICC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCTD12 ZFAT KERA NFASC ZFHX4 MYO15A	8.92e-05	183	176	6	262387ee8d43b96e5f1a77c75124459a506a6172
ToppCell	5'-Adult-LymphNode-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ROBO4 TSHZ2 LAMA5 TNS2 DCHS1 MCF2L	8.92e-05	183	176	6	a644258ba90acc62d571623e429d72ffc4b69203
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-stromal_related\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCTD12 ZFAT KERA NFASC ZFHX4 MYO15A	8.92e-05	183	176	6	c85a707acbcb582912e8ac080a36d05f91cfd7a2
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4\|TCGA-Pancreas / Sample_Type by Project: Shred V9	TSHZ2 REV3L ZFHX4 ABCA6 NRK CRYBG3	9.19e-05	184	176	6	67164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell	Cerebellum-Macroglia-OLIGODENDROCYTE\|Cerebellum / BrainAtlas - Mouse McCarroll V32	CCDC187 ADGRV1 ITGAD KCNU1 ABCA6	9.38e-05	115	176	5	15b2c11225802cc15c01165d84a755432f02d82f
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Papillary_Renal_Cell_Carcinoma\|TCGA-Kidney / Sample_Type by Project: Shred V9	MRM1 TEDC2 EVPL DBNDD1 HS3ST1 PCSK4	9.47e-05	185	176	6	46f4f6f20b1e152922f6f2ba1244c56e48a49b79
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	KCTD12 SIRPA ADGRV1 PRRC2C USH2A PIWIL3	9.75e-05	186	176	6	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	E17.5-Epithelial-alveolar_epithelial_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PDE7A EPS8L1 SH2D4A BRD7 PKP2 MSLN	9.75e-05	186	176	6	a7a2ef8392a045a62fa4d0983577711d5d397dc4
ToppCell	PCW_05-06-Neuronal\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	FAM78B BRSK2 DOCK10 NFASC ADGRV1 PCBP4	1.00e-04	187	176	6	03a2ed85b171c887d4f3b0f4fe2e1cb4a853e658
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	DDI2 NAA35 MTOR TNFRSF13B POLL LRRC37B	1.00e-04	187	176	6	c8278525b3e1d3f3f4defcaf109cce22dd2e157a
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	LAMA5 EPS8L1 FCHO1 PTPRQ PKP2 MSLN	1.00e-04	187	176	6	8e8f1f2a78ac5f13a414fd448af7d7ff1ea86f0f
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	COL6A3 FRAS1 NFASC ZFPM2 ABCA6 PCDH15	1.00e-04	187	176	6	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ROBO4 RPS6KA2 ICAM2 TDRD10 CRYBG3 PZP	1.00e-04	187	176	6	d9d10ed7c905778a29a0dc3ced3eef02a6b1de5c
ToppCell	Globus_pallidus-Macroglia-OLIGODENDROCYTE-O1\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	GPT ADGRV1 ITGAD SSPOP ABCA6	1.06e-04	118	176	5	d0dd5c882cd9e0a5eb0cb08e47877292126bd4ae
ToppCell	Globus_pallidus-Macroglia-OLIGODENDROCYTE-O1-Trf\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	GPT ADGRV1 ITGAD SSPOP ABCA6	1.06e-04	118	176	5	4283699cb3ca7a112faa07727dfdc0b0a67fb779
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_3\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	DDI2 NAA35 MTOR TNFRSF13B POLL LRRC37B	1.06e-04	189	176	6	99b01893da9f9f7c9528afaffad178285211738b
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TSHZ2 NFASC TNS2 ABCA6 GRIP2 CRYBG3	1.06e-04	189	176	6	c734e5693808a0333139e87bd5be2597a9252afe
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ2 ZFPM2 TRANK1 ZFHX4 ABCA6	1.10e-04	190	176	6	efb757f11c2809e66ddb48a5c84f5433f111cb7c
ToppCell	E17.5-Epithelial-alveolar_epithelial_cell-type_I_pneumocyte\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FRAS1 PDE7A EPS8L1 SH2D4A PKP2 MSLN	1.10e-04	190	176	6	15f314517ed47b12d287a12a7d18cb383310e25a
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	LAMA5 EPS8L1 FCHO1 PTPRQ PKP2 MSLN	1.13e-04	191	176	6	4c4eb61e6179d2f8fc524d2f813db9cba84f67a2
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TSHZ2 NFASC TNS2 ABCA6 GRIP2 CRYBG3	1.13e-04	191	176	6	806b94f567ea09a9f443cd4091e70cdb1253ac08
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL6A3 FRAS1 NFASC ZFPM2 ABCA6 PCDH15	1.13e-04	191	176	6	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ2 NFASC ZFPM2 ZFHX4 ABCA6	1.16e-04	192	176	6	5105e4b577408b4e1a62d0a44c23c2b830ccad88
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ2 NFASC ZFPM2 ZFHX4 ABCA6	1.16e-04	192	176	6	d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	COL6A3 DENND4A TSHZ2 DOCK10 ARFGEF1 NLRP1	1.16e-04	192	176	6	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL6A3 FRAS1 NFASC ZFPM2 ABCA6 PCDH15	1.16e-04	192	176	6	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	DDI2 ADGRV1 DENND4C EFR3A FAM120A CRYBG3	1.19e-04	193	176	6	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ2 NFASC ZFPM2 ZFHX4 ABCA6	1.19e-04	193	176	6	c8c21eee8c6c086dc2faf416669cd4a002870fbe
ToppCell	human_hepatoblastoma-Tumor_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	FRAS1 TSHZ2 ZRANB3 DNAH14 SH2D4A RPTOR	1.19e-04	193	176	6	503a979328c68b096680b71359a26f02fafdff35
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ2 NFASC ZFPM2 ZFHX4 ABCA6	1.19e-04	193	176	6	5b602b1702283184bd3943c2a6f2290b7c37e407
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ2 NFASC ZFPM2 TRANK1 ABCA6	1.23e-04	194	176	6	81713e0409e8be695ba5dfdc67a997b33435dd9e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ2 ZFPM2 TRANK1 ZFHX4 ABCA6	1.23e-04	194	176	6	c49f72441b3557e2c3a9c4239e68c0cf0652814b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ2 NFASC ZFPM2 ABCA6 KANK4	1.23e-04	194	176	6	cf0244a29934e515446ac917d3c30672b460fb04
ToppCell	10x5'v1-week_14-16-Endothelial-stroma-proliferating_EC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ROBO4 TSHZ2 FFAR2 ECM1 DCHS1 TDRD10	1.23e-04	194	176	6	8a4be91414a2e69dd410aa75791f16008204c9a1
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ2 NFASC ZFPM2 ZFHX4 ABCA6	1.23e-04	194	176	6	e03ba6caed59fa64d4d9b042593469d4a6a3dc10
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ2 NFASC ZFPM2 ABCA6 KANK4	1.23e-04	194	176	6	ba7f971fb9a19423602da60770f23d9fead4a451
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TSHZ2 NFASC SIRPA PTPRQ DCBLD2 MSLN	1.23e-04	194	176	6	43eb677a76634bb9a48a40e0d607c4936ae64bcc
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ2 NFASC ZFPM2 TRANK1 ABCA6	1.23e-04	194	176	6	627cffe2d448e74fc5df92e74e5b922a73304137
ToppCell	Parenchymal-NucSeq-Stromal-Mesofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FRAS1 DSCAML1 ZFPM2 ZFHX4 PTPRQ MSLN	1.26e-04	195	176	6	a52685f76eca269a7d2de8dfc317439483e233fa
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ2 NFASC ZFPM2 ZFHX4 ABCA6	1.26e-04	195	176	6	cad6563cc51d212554152c727fc2c249c6a07e4d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ2 NFASC ZFPM2 ZFHX4 ABCA6	1.26e-04	195	176	6	3c3703f092b6fc1b7333426fb5e2823bfb74bb57
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ2 NFASC ZFPM2 ZFHX4 ABCA6	1.26e-04	195	176	6	783bfa8110161cbd6def50ce849cae676c39c458
ToppCell	Parenchymal-NucSeq-Stromal-Mesofibroblastic-Mesothelia\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FRAS1 DSCAML1 ZFPM2 ZFHX4 PTPRQ MSLN	1.26e-04	195	176	6	224deeba2f60def6543a55bb4f5ee6c7fdab3f02
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ2 NFASC REV3L ZFPM2 ABCA6	1.30e-04	196	176	6	2b36b9a40fe415917afccff99ad9c3474e087d0d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ2 NFASC ZFPM2 ZFHX4 ABCA6	1.30e-04	196	176	6	3a6c942e2907aa07b5e12dbf9019d18f7bfca507
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ2 NFASC ZFPM2 ZFHX4 ABCA6	1.30e-04	196	176	6	bba88e91cd3e3a6f5a9b443e3a4da33c5b455e70
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ2 NFASC ZFPM2 ZFHX4 ABCA6	1.33e-04	197	176	6	09946ee8dfb15a2a32da06e5b331f3277ee934f4
ToppCell	Parenchymal-10x5prime-Stromal-Mesofibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FRAS1 ISM2 ZFHX4 NRK PTPRQ MSLN	1.33e-04	197	176	6	88a86286b9c3ea3b076d7464faec42d0392ee7f8
Computational	Neighborhood of CASP2	DENND4A TBC1D22B CCAR1 CRAMP1	1.27e-04	27	105	4	GCM_CASP2
Drug	Isradipine [75695-93-1]; Down 200; 10.8uM; PC3; HT_HG-U133A	ZC3H12A CTC1 MRM1 EVPL EPS8L1 SIRPA RAD54L2 ZNF79 PRR14L ARHGEF4 ZNF839	3.69e-07	194	177	11	6347_DN
Drug	GSK-3 Inhibitor IX; Up 200; 0.5uM; MCF7; HT_HG-U133A	UBR2 FXR2 MRM1 TNS2 RAD54L2 DHX30 IKBKE POLL ZNF79 MCF2L	3.00e-06	194	177	10	7044_UP
Drug	Ketorolac tromethamine [74103-07-4]; Down 200; 10.6uM; HL60; HT_HG-U133A	ICAM2 UBR4 NLRP1 EPS8L1 RAD54L2 ABCA7 ZNF79 ZNF839 CAMSAP2 MAP2K7	3.14e-06	195	177	10	3110_DN
Drug	Cefotaxime sodium salt [64485-93-4]; Down 200; 8.4uM; MCF7; HT_HG-U133A	KMT2B DSCAM KDM5A MRM1 RPS6KA2 MARCHF6 GON4L PSPH RAD54L2 POLL	3.44e-06	197	177	10	2235_DN
Drug	Bemegride [64-65-3]; Down 200; 25.8uM; PC3; HT_HG-U133A	ERAP1 TEDC2 RPS6KA2 REV3L DBNDD1 ZNF79 ARHGEF4 ZNF839 HS3ST1 ARHGAP33	3.60e-06	198	177	10	6668_DN
Drug	Ranitidine hydrochloride [66357-59-3]; Up 200; 11.4uM; HL60; HG-U133A	ZC3H12A TEDC2 PSPH SPX TRANK1 TNFRSF13B PRR14L DMBT1 ARHGAP33	2.20e-05	194	177	9	1404_UP
Drug	Thioguanosine [85-31-4]; Down 200; 12.6uM; HL60; HT_HG-U133A	UBR2 KDM5A ERAP1 MARCHF6 PEX1 ARFGEF1 C2CD3 PRRC2C PPP6R3	2.20e-05	194	177	9	1264_DN
Drug	Protriptyline hydrochloride [1225-55-4]; Down 200; 13.4uM; PC3; HT_HG-U133A	FXR2 MRM1 EPS8L1 ECM1 ZNF79 ARHGEF4 ZNF839 PCBP4 PYCR3	2.29e-05	195	177	9	6338_DN
Drug	Prazosin hydrochloride [19237-84-4]; Down 200; 9.6uM; PC3; HT_HG-U133A	ERAP1 RPS6KA2 LAMA5 NLRP1 EVPL EPS8L1 DLG3 ARHGEF4 PCBP4	2.38e-05	196	177	9	6315_DN
Drug	Nitrofural [59-87-0]; Up 200; 20.2uM; MCF7; HT_HG-U133A	DSCAM PSPH FCHO1 DENND4C SH2D4A PHACTR4 DLG3 ZNF79 PCBP4	2.48e-05	197	177	9	5321_UP
Drug	Brompheniramine maleate [980-71-2]; Up 200; 9.2uM; HL60; HT_HG-U133A	MRM1 TEDC2 ICAM2 FANCF MOGS POLL CDC5L CHPF MAP2K7	2.58e-05	198	177	9	1335_UP
Drug	retinoic acid; Down 200; 1uM; PC3; HT_HG-U133A	KDM5A ERAP1 TEDC2 RPS6KA2 GON4L DBNDD1 DNAJA4 POLL ARHGAP33	2.58e-05	198	177	9	4435_DN
Drug	Androsterone [53-41-8]; Up 200; 13.8uM; MCF7; HT_HG-U133A	FXR2 EVPL NUDCD3 ABCA7 IKBKE MAPKBP1 DDX28 ARHGAP33 ACSL5	2.58e-05	198	177	9	2650_UP
Drug	trifluoperazine dihydrochloride; Down 200; 10uM; MCF7; HG-U133A	ERAP1 TEDC2 TNS2 MAP3K4 FANCF DLG3 MCF2L DDX28 ACSL5	2.58e-05	198	177	9	421_DN
Drug	Metampicillin sodium salt [6489-61-8]; Down 200; 10.4uM; HL60; HG-U133A	DENND4A MARCHF6 EPS8L1 FCHO1 KLHL20 EFR3A DNAJA4 PRRC2C MCF2L	2.68e-05	199	177	9	1440_DN
Drug	alpha-estradiol; Down 200; 0.01uM; MCF7; HT_HG-U133A	DSCAM MARCHF6 PEX1 GON4L CASP9 EPS8L1 POLL ZNF79 ARHGAP33	2.68e-05	199	177	9	5570_DN
Drug	Hydrastinine hydrochloride [4884-68-8]; Down 200; 16.4uM; MCF7; HT_HG-U133A	DSCAM ERAP1 MRM1 SH2D4A DBNDD1 MTOR DLG3 POLL ZNF79	2.68e-05	199	177	9	5494_DN
Drug	Vancomycin hydrochloride [1404-93-9]; Down 200; 2.6uM; PC3; HT_HG-U133A	DOCK10 EPS8L1 DBNDD1 DNAJA4 POLL CDC5L MCF2L PCBP4 ACSL5	2.79e-05	200	177	9	4598_DN
Disease	plasminogen activator inhibitor 1 measurement	RPS6KA2 UBR4 RFX7 ZFPM2 MAP3K4	1.55e-05	54	171	5	EFO_0004792
Disease	Iodide organification defect	TPO DUOX2	3.34e-05	2	171	2	C2750949
Disease	obsolete_red blood cell distribution width	ZC3H12A ABL1 KMT2B FXR2 ASAH2 FFAR2 LRRC37A2 DUOX2 SIRPA PPP1R3G ITGAD ABCA7 DENND4C ZFPM2 ABCA6 DNAJA4 PRRC2C LRRC37B PYCR3 PPP6R3	1.12e-04	1347	171	20	EFO_0005192
Disease	Myxedema, Congenital	TPO DUOX2	1.99e-04	4	171	2	C1578691
Disease	autosomal dominant polycystic kidney disease (is_implicated_in)	MTOR PKD1	1.99e-04	4	171	2	DOID:898 (is_implicated_in)
Disease	congenital hypothyroidism (is_implicated_in)	TPO DUOX2	1.99e-04	4	171	2	DOID:0050328 (is_implicated_in)
Disease	Endemic Cretinism	TPO DUOX2	1.99e-04	4	171	2	C0342200
Disease	Usher Syndrome, Type II	PCDH15 USH2A	3.30e-04	5	171	2	C1568249
Disease	Thyroid Dyshormonogenesis 1	TPO DUOX2	4.93e-04	6	171	2	C1848805
Disease	Congenital hypothyroidism	TPO DUOX2	4.93e-04	6	171	2	cv:C0010308
Disease	pleckstrin homology domain-containing family A member 1 measurement	ZFPM2 DMBT1	6.88e-04	7	171	2	EFO_0802873
Disease	Goiter	TPO DUOX2	6.88e-04	7	171	2	C0018021
Disease	azoospermia	SIRPA PLCH2	6.88e-04	7	171	2	EFO_0000279
Disease	mean corpuscular hemoglobin concentration	DENND4A ZFAT ACTRT3 FFAR2 LRRC37A2 GON4L SIRPA ABCA7 ABCA6 CHTF18 TNFRSF13B CC2D2A MYO15A MAP2K7 PYCR3 PPP6R3	7.31e-04	1105	171	16	EFO_0004528
Disease	alcohol use disorder (implicated_via_orthology)	KDM5A EPS8L1 PSPH KCNU1 BRD7 CDC5L	9.95e-04	195	171	6	DOID:1574 (implicated_via_orthology)
Disease	synaptotagmin-11 measurement	GON4L ZFPM2	1.17e-03	9	171	2	EFO_0802108
Disease	essential tremor	IQANK1 NFASC NLRP1 DSCAML1 CDC5L	1.20e-03	136	171	5	EFO_0003108
Disease	Disorder of eye	FRAS1 ADGRV1 PCDH15 CC2D2A ROM1 USH2A	1.53e-03	212	171	6	C0015397
Disease	serum iron measurement	ZFAT FFAR2 DUOX2 DCHS1	1.60e-03	86	171	4	EFO_0006332
Disease	autism spectrum disorder (implicated_via_orthology)	DSCAM KDM5A FXR2 DSCAML1 PKP2	1.97e-03	152	171	5	DOID:0060041 (implicated_via_orthology)
Disease	waist-hip ratio, body mass index	MRM1 EFR3A	2.12e-03	12	171	2	EFO_0004340, EFO_0004343
Disease	disks large homolog 3 measurement	ZFPM2 DLG3	2.12e-03	12	171	2	EFO_0802472
Disease	ureteral obstruction (biomarker_via_orthology)	ABL1 CASP9 MTOR	2.27e-03	45	171	3	DOID:5199 (biomarker_via_orthology)
Disease	interleukin 6 receptor subunit alpha measurement	OTUD7B TDRD10	2.50e-03	13	171	2	EFO_0008187
Disease	Congenital Hypothyroidism	TPO DUOX2	2.50e-03	13	171	2	C0010308
Disease	mean platelet volume	ERAP1 DOCK10 NFASC SIRPA ZFPM2 SPX TRANK1 SH2D4A TNFRSF13B DLG3 MCF2L PHIP ACSL5 MYBPC3	2.56e-03	1020	171	14	EFO_0004584
Disease	brain volume measurement	FRAS1 MRM1 LRRC37A2 BRSK2 GON4L DSCAML1 RIC8B ZFHX4 SELENOO PZP	2.57e-03	595	171	10	EFO_0006930
Disease	Alzheimer disease, APOE carrier status	COL6A3 DSCAM TSHZ2 RPS6KA2	2.58e-03	98	171	4	EFO_0007659, MONDO_0004975
Disease	hearing impairment	ADGRV1 PCDH15 MYO15A USH2A	2.58e-03	98	171	4	C1384666
Disease	blood cobalt measurement	TSHZ2 RPTOR CC2D2A USH2A	2.87e-03	101	171	4	EFO_0007577
Disease	congenital hypothyroidism (implicated_via_orthology)	TPO DUOX2	2.90e-03	14	171	2	DOID:0050328 (implicated_via_orthology)
Disease	Left ventricular noncompaction	PKP2 MYBPC3	2.90e-03	14	171	2	C1960469
Disease	Nonsyndromic Hearing Loss and Deafness, Autosomal Recessive	PTPRQ PCDH15 MYO15A	3.25e-03	51	171	3	cv:CN043650
Disease	Down syndrome (implicated_via_orthology)	DSCAM DSCAML1	3.34e-03	15	171	2	DOID:14250 (implicated_via_orthology)
Disease	response to olanzapine	ADGRV1 ZFPM2	3.34e-03	15	171	2	GO_0097333
Disease	urate measurement, bone density	FRAS1 DSCAM TSHZ2 AHCTF1 LAMA5 DNAH14 FSIP2 SH2D4A DMBT1 USH2A	3.40e-03	619	171	10	EFO_0003923, EFO_0004531
Disease	transferrin saturation measurement	FFAR2 DUOX2	3.80e-03	16	171	2	EFO_0006333
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	MTOR PKD1	3.80e-03	16	171	2	DOID:0110861 (implicated_via_orthology)
Disease	Ciliopathies	ADGRV1 PCDH15 CC2D2A USH2A	3.90e-03	110	171	4	C4277690
Disease	Dystonia, Limb	COL6A3 KMT2B	4.29e-03	17	171	2	C0751093
Disease	Dystonia, Diurnal	COL6A3 KMT2B	4.29e-03	17	171	2	C0393610
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	KMT2B RFX7	4.29e-03	17	171	2	DOID:0060307 (is_implicated_in)
Disease	bilirubin measurement	ABL1 REV3L SPX SCAP TNFRSF13B ROM1 DMBT1 PHIP	4.40e-03	442	171	8	EFO_0004570
Disease	immature platelet fraction	DOCK10 SIRPA ZFPM2 SH2D4A	4.43e-03	114	171	4	EFO_0009187
Disease	Dystonia, Paroxysmal	COL6A3 KMT2B	4.81e-03	18	171	2	C0393588
Disease	psoriasis	IL12RB2 KCNH7 ERAP1 REV3L IFNLR1 IKBKE	5.30e-03	273	171	6	EFO_0000676
Disease	psoriasis vulgaris	KCNH7 ERAP1 IFNLR1	5.38e-03	61	171	3	EFO_1001494

Protein segments in the cluster

Peptide	Gene	Start	Entry
PRVQLPPRAVERAQE	GPT	416	P24298
VVLQPPELTARPQRS	CCDC137	201	Q6PK04
PPTLPSRLVQRLQEV	CHTF18	511	Q8WVB6
ISQLQAELRRPPPAP	B3GAT3	51	O94766
PRPSEVNETILRPLN	CDC5L	546	Q99459
VNETILRPLNVEPPL	CDC5L	551	Q99459
QALVRSLLGPPPVLR	CCDC187	291	A0A096LP49
SKIVPLEPPRLQRFQ	CTC1	1166	Q2NKJ3
SIRPIQLEPLGINEP	CRYBG3	2651	Q68DQ2
LQEAQNERLSTRPPP	BRD7	556	Q9NPI1
PVLITEPALNPLANR	ACTRT3	101	Q9BYD9
PPVRIVSQPQPARRL	CCAR1	281	Q8IX12
IQPRSVDNRPQAPLV	ARFGEF1	1576	Q9Y6D6
QQEQPRILSRMEPIP	FAM78B	216	Q5VT40
PGQLPQEPRTSLLII	ABCA6	896	Q8N139
PPPLNVLQVPVVRLA	ADGRV1	3931	Q8WXG9
PQQQVLVLAEPRRKP	ARHGEF4	661	Q9NR80
PQLEALLPPRQKVRI	DNAJA4	341	Q8WW22
PQLPPRVLAQEVICL	RAD54L2	171	Q9Y4B4
TQRRPCTIQVPEPIL	DHX30	341	Q7L2E3
LPLQKRLVPTRSIPV	C3orf22	56	Q8N5N4
DRLAQILELTIRPPP	EFR3A	776	Q14156
QLLPQPRVRSLPLLG	ABCA7	1756	Q8IZY2
RLLRLPQLPPGAQLV	POLL	96	Q9UGP5
VPFPSPQRPRILVQL	DENND4A	356	Q7Z401
LEIPLPVTNPIVRNA	PZP	1116	P20742
TRPPRPILQRQDDIV	OTUD7B	76	Q6GQQ9
LLPVGEPVTNVRLQP	FCHO1	791	O14526
NVSRPPVTLRLVIPA	PCBP4	96	P57723
LLRQEPPVPALRLDA	DCHS1	1476	Q96JQ0
LNPEQRLRQVPVPEP	LRRC37A3	846	O60309
AVALLQPPLSRRPQE	FANCF	206	Q9NPI8
IRQPQPAPVHILLLS	FFAR2	36	O15552
DEPPRMTLQPLRVQL	FRAS1	1956	Q86XX4
LIRQAPPVIRQAPPV	MAGEL2	436	Q9UJ55
QAPPVIRQAPPVIRQ	MAGEL2	446	Q9UJ55
IRQAPPVIRQAPAVI	MAGEL2	451	Q9UJ55
PVIRQAPAVIRQAPP	MAGEL2	456	Q9UJ55
QAPPVIRQAPPLIRQ	MAGEL2	481	Q9UJ55
LNPEQRLRQVPVPEP	LRRC37A2	846	A6NM11
LNPEQRLRQVPVPEP	LRRC37A	846	A6NMS7
IVTLERLRPVNPNPL	FXR2	116	P51116
RPRLAPPQNVTLLSQ	IFNLR1	21	Q8IU57
VPREPPILPRIQEQF	NUDCD3	161	Q8IVD9
QVPQVAPVRTPRLQA	MYO15A	2021	Q9UKN7
PRLQAEPRVTLPLDI	MYO15A	2031	Q9UKN7
PERVNPILPIKTVNR	KCNH7	141	Q9NS40
QLIVPLIPSIVDRAP	ASAH2	636	Q9NR71
QPLLEAPQRPRAAEV	C17orf58	51	Q2M2W7
LPEQEQRPPLVQQRF	ZFPM2	746	Q8WW38
NRIIERLNRVPAPPD	IKBKE	701	Q14164
PPPRALQAESRQLVD	IL12RB2	751	Q99665
QPIPRKVQIRSLPSL	BRSK2	281	Q8IWQ3
QALEEPQLPNPRRLS	DUOX2	71	Q9NRD8
EPHISPIAPIIRNIL	FSIP2	1771	Q5CZC0
VIRRLLSQLIPPPIT	FSIP2	4146	Q5CZC0
PRQEQIALLAPEPLL	ERAP1	126	Q9NZ08
PPRTPEVTPLRLELQ	ISM2	96	Q6H9L7
AVRVQSRPTPILPLI	PCSK4	456	Q6UW60
NLDISPQRPRPTLQL	MAP2K7	31	O14733
PLPPVREVTRHVIQV	TPO	201	P07202
QLPVLPLDRPVPQHV	PDE7A	6	Q13946
TPAPIRQILSRPERL	NLRP1	391	Q9C000
PKRPRVAPLQESIQA	EVPL	841	Q92817
LSPPGAQRLVRVPVL	HMX1	271	Q9NP08
EPLPVVRIPVALQRQ	DDX28	31	Q9NUL7
PLLVSARRPELNQPA	DDX28	66	Q9NUL7
LVIVAPLRVPLDQTP	MARCHF6	741	O60337
TPEERLPEVVPLLNR	LRRC37B	126	Q96QE4
LSPKQRLRQVPVPEP	LRRC37B	536	Q96QE4
HVLLVPEPARQLPQR	GDPGP1	166	Q6ZNW5
LLPVLGQPIIRSIPQ	MSLN	251	Q13421
APRRPLPQVATLIDR	MSLN	411	Q13421
ILNPPPQVRIRKNTL	KCNU1	571	A8MYU2
QSRPRKPTLQPVLQL	KMT2B	1121	Q9UMN6
RQRPPQTPLRLLVDA	FAM120A	36	Q9NZB2
PVQPRIVARLNLTSP	LAMA5	911	O15230
QLRRPVPLSARVQPV	PRSS33	131	Q8NF86
RLPPLPLHIRIQQAL	PHACTR4	411	Q8IZ21
RPIPVRLEALPQVES	KDM5A	1031	P29375
AVQLKPRPPQGLVRV	MOGS	661	Q13724
SLILQQTPRHVRPPL	PTPRQ	1131	Q9UMZ3
PVRFLQAQPIVPVQR	PASD1	601	Q8IV76
QLLPSRRGEQLTLPP	POM121C	486	A8CG34
VREPIPSPQNLRPVL	ITGAD	736	Q13349
LDVPPRMLSPRNQLI	NFASC	426	O94856
IPELRTPEELNPIIV	PCDH15	286	Q96QU1
RLVRVHDVIQQLPPP	ARHGAP33	421	O14559
RNVPRCIIILVLQEP	BAGE3	56	Q86Y29
SVIQIRQQPRDPPTE	FKBPL	31	Q9UIM3
RRPQLPQVLQHVRLP	KLHL20	246	Q9Y2M5
ESALLQEIPTPRPRR	CC2D2A	116	Q9P2K1
PRRNDEVQLSPPEVI	C2CD3	1586	Q4AC94
IDTNKIQLPRPQRFP	DOCK10	1006	Q96BY6
PVPAPGLLQVTERRQ	DBNDD1	46	Q9H9R9
QLEEISRAQLVPLPP	AHSG	181	P02765
VNLLVQVPPDQPRLT	DSCAML1	1376	Q8TD84
PVVPPREASIRNLAR	DSCAML1	1921	Q8TD84
PTLENLTPVVLRPEI	CASP9	101	P55211
EELSRLQPVLQPLPS	COL6A3	1211	P12111
RLPLKVPIELQPRNN	CRAMP1	316	Q96RY5
PLVVQRTLLPRPSEN	CRAMP1	886	Q96RY5
VLRIPHPIQPATVLQ	GON4L	1036	Q3T8J9
VPPPPRTLLEALEQR	CC2D1A	341	Q6P1N0
IPFPSPQRPRILVQL	DENND4C	356	Q5VZ89
PNLTPKPLRRQVTVA	ABL1	811	P00519
LITRPQPVLPLLDLN	ACSL5	31	Q9ULC5
RRQPPPETIMEVNLL	DLG3	216	Q92796
TQDPLRRVRDPTPIV	DNAH14	96	Q0VDD8
KLAARQTRPVQPVAP	MCF2L	556	O15068
QTRPVQPVAPRPEAL	MCF2L	561	O15068
FLLQVQTRPLREPSP	MAPKBP1	1101	O60336
PLRPFVPEQELLRSL	ATAT1	281	Q5SQI0
QSPAERVLLPQLSLP	KANK4	466	Q5T7N3
VPRNLPATDPLQREL	ECM1	321	Q16610
RLLDLVVQPVPRPSQ	AHCTF1	1116	Q8WYP5
LVPQPRVPPVIVLEN	EMC9	121	Q9Y3B6
LPPIIARFIRVNPTQ	DCBLD2	421	Q96PD2
VVILRQKENADPRPP	DDI2	71	Q5TDH0
ETPPLQRRPSVRAVI	EPS8L1	186	Q8TE68
LEILPVPQSQRPLRP	GRIP2	326	Q9C0E4
RNVPRCIIILVLQEP	BAGE2	56	Q86Y30
DPPLPGRAQRIRQVL	C7orf50	176	Q9BRJ6
VLGPIQLQTPPRREE	DMBT1	2396	Q9UGM3
RPLQEEVPVVRPLQP	PIWIL3	46	Q7Z3Z3
LLPVIPVTLRLNPRE	SCAP	651	Q12770
ELPELVRRLGAPQQP	KCTD12	121	Q96CX2
PPPDQVSRLEILNVL	PEX1	1006	O43933
QRTPRPNELKITPLN	CAMSAP2	986	Q08AD1
SPELGPPRLRQVRLQ	PKD1	3741	P98161
SQIRIRKTIPRPDPN	PRR14L	2011	Q5THK1
LQVIPQLIARIDTPR	MTOR	1936	P42345
LVAQPQLVPSRPAEL	HS3ST1	11	O14792
ISDPRVPEIRQPIDN	MAP3K4	466	Q9Y6R4
NPLEIIIPQNIIILP	NRK	1451	Q7Z2Y5
ILNLQVQVPPDQPRL	DSCAM	1371	O60469
LLRRKIQQPLASNPP	USH2A	2856	O75445
RRSPNPQLLTIPEAA	SPX	71	Q9BT56
KQQSLPLRPIIPLVA	TBC1D22B	151	Q9NU19
PLRPIIPLVARISDQ	TBC1D22B	156	Q9NU19
RQIHIDIPRTNPLIP	TBC1D22B	266	Q9NU19
LTFQRQELLRPPLPG	SSPOP	2521	A2VEC9
LQELRAAVAEQPPRP	TEDC2	316	Q7L2K0
DQVLPPLRDVTNRPE	RIC8B	386	Q9NVN3
RTPDMIQQPRAPLVL	TDRD10	111	Q5VZ19
CQLLLTILPRRQLPP	MRM1	271	Q6IN84
PQQLPEAVPAGLVRR	PRDM15	371	P57071
VPSPLPRSLEQLQLA	KERA	136	O60938
QILSQPNLVPPLVRA	PRRC2C	2731	Q9Y520
QPIRSPLREAIPTNA	SPATA32	186	Q96LK8
QPTPLRQPRLVALSE	SELENOO	86	Q9BVL4
RVPPTLEVTQQPVRA	SIRPA	251	P78324
PRDPQLVPILIEAAR	NSDHL	206	Q15738
PQVPLRPSVNVLTDL	PRR32	51	B1ATL7
AEEPQVPPAVLSRLR	PPP1R3G	151	B7ZBB8
QLVPAPPTVLRVLRG	WDR13	201	Q9H1Z4
PPRQVILTLQPTLVA	ICAM2	111	P13598
PAEQLQVLLPVRVQL	IQANK1	541	A8MXQ7
EELLPPNTRVLRVLP	PYCR3	111	Q53H96
PNTRVLRVLPNLPCV	PYCR3	116	Q53H96
NRNPPEQLPIVLQVL	RPTOR	426	Q8N122
VPAVRRLPPQLAQLS	ROBO4	601	Q8WZ75
QLLRPLSRVEILPVP	CHPF	486	Q8IZ52
PQVLRASSELPNRLP	LINC01561	16	Q8N1V8
VRLVPPQVNKADRTP	RINL	16	Q6ZS11
RVAQPRLRQPPETLL	URGCP	576	Q8TCY9
QPLIDPQETVLRVPV	ZFHX4	3381	Q86UP3
NVDEIIIPLRPLSTP	ZFAT	41	Q9P243
QPRPDVPITDQHILR	ZC3H12A	186	Q5D1E8
EPLVNQRLLPPTFPR	NAA35	301	Q5VZE5
RLGPLLEQEIPQSVP	PHIP	81	Q8WWQ0
RPPPAQVPREVLKVQ	TFE3	166	P19532
PQEPLVISPINTRAR	REV3L	2176	O60673
PSREQVQRLIAEQPP	PSPH	71	P78330
PLVLPLQPRIRLAQG	ROM1	6	Q03395
LIQPICIPPTGQRVR	TMPRSS7	711	Q7RTY8
QRPPIPDELQPRSLA	PLCH2	1211	O75038
PQRVSQVRIPKALPS	ZNF256	71	Q9Y2P7
ERLQSPLRVPQKPER	SH2D4A	271	Q9H788
AVPSPIPVQRTRQLV	RFX7	266	Q2KHR2
QIRPNLTNKLRPIAP	TSHZ2	566	Q9NRE2
SPQLLRVQPLVRTEP	ZNF839	31	A8K0R7
NKLRSPVNLPPELRR	TNFRSF13B	106	O14836
AVIDLNPRPLEPIIL	TRANK1	1016	O15050
LSNTVIPLLLPPRNI	UBR2	1216	Q8IWV8
NPPQVIRTLLPLLLE	UBR4	1306	Q5T4S7
LLRLLTCIEPPQPRQ	PPP6R3	166	Q5H9R7
FNLRPVLSPQQRVPV	ZNF79	151	Q15937
VLSPQQRVPVEARPR	ZNF79	156	Q15937
VRPLVPLQPVTQNRA	PKP2	271	Q99959
ALPPVELRRNTAPVR	TNS2	81	Q63HR2
VLTQLPPKVRQRIPF	ZRANB3	261	Q5FWF4
NVTVKPARRVNLPPV	KIAA0319	421	Q5VV43
ALNRTPQAPRLEPVL	RPS6KA2	701	Q15349
EPPVLITRPLEDQLV	MYBPC3	451	Q14896
PVTVQEILQRPRLQL	MYBPC3	961	Q14896