Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	NIPSNAP	NIPSNAP3A NIPSNAP3B	2.81e-05	4	41	2	IPR012577
Domain	NIPSNAP	NIPSNAP3A NIPSNAP3B	2.81e-05	4	41	2	PF07978
Domain	Dimeric_a/b-barrel	NIPSNAP3A NIPSNAP3B	9.81e-05	7	41	2	IPR011008
Domain	ZINC_FINGER_C2H2_2	KLF16 ZNF627 ZBTB16 GPATCH8 PRDM14 ZNF596	6.51e-03	775	41	6	PS50157
Domain	ZINC_FINGER_C2H2_1	KLF16 ZNF627 ZBTB16 GPATCH8 PRDM14 ZNF596	6.59e-03	777	41	6	PS00028
Domain	Znf_C2H2-like	KLF16 ZNF627 ZBTB16 GPATCH8 PRDM14 ZNF596	7.39e-03	796	41	6	IPR015880
Domain	Znf_C2H2	KLF16 ZNF627 ZBTB16 GPATCH8 PRDM14 ZNF596	7.80e-03	805	41	6	IPR007087
Domain	ZnF_C2H2	KLF16 ZNF627 ZBTB16 GPATCH8 PRDM14 ZNF596	7.94e-03	808	41	6	SM00355
Domain	USP_CS	USP31 USP42	9.23e-03	66	41	2	IPR018200
Domain	USP_1	USP31 USP42	1.03e-02	70	41	2	PS00972
Domain	UCH	USP31 USP42	1.06e-02	71	41	2	PF00443
Domain	USP_2	USP31 USP42	1.06e-02	71	41	2	PS00973
Domain	USP_3	USP31 USP42	1.09e-02	72	41	2	PS50235
Domain	USP_dom	USP31 USP42	1.09e-02	72	41	2	IPR028889
Domain	Peptidase_C19_UCH	USP31 USP42	1.09e-02	72	41	2	IPR001394
Domain	-	KLF16 ZNF627 ZBTB16 PRDM14 ZNF596	1.59e-02	679	41	5	3.30.160.60
Domain	-	UPF3A SPEN RBM12B	1.63e-02	244	41	3	3.30.70.330
Domain	zf-C2H2	KLF16 ZNF627 ZBTB16 PRDM14 ZNF596	1.72e-02	693	41	5	PF00096
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	JARID2 PPP2R1A PQBP1 SPEN USP42 BIRC6 CRISPLD1 CLK2 CDK13	3.27e-09	469	41	9	27634302
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	JARID2 PRPF38B GPATCH8 PQBP1 SPEN USP42 CENPF PRDM14	1.81e-08	396	41	8	26687479
Pubmed	Interaction between human tRNA synthetases involves repeated sequence elements.	IARS1 GARS1	1.36e-06	2	41	2	8816763
Pubmed	Expression pattern and raft association of NIPSNAP3 and NIPSNAP4, highly homologous proteins encoded by genes in close proximity to the ATP-binding cassette transporter A1.	NIPSNAP3A NIPSNAP3B	1.36e-06	2	41	2	15177564
Pubmed	Proteomic analysis reveals novel ligands and substrates for LNX1 E3 ubiquitin ligase.	PPP2R1A RBM12B CDK13 IARS1	2.34e-06	79	41	4	29121065
Pubmed	Frequent amplification of CENPF, GMNN and CDK13 genes in hepatocellular carcinomas.	CENPF CDK13	4.06e-06	3	41	2	22912832
Pubmed	PRDM14 ensures naive pluripotency through dual regulation of signaling and epigenetic pathways in mouse embryonic stem cells.	JARID2 PRDM14	4.06e-06	3	41	2	23333148
Pubmed	Jarid2 is induced by TCR signalling and controls iNKT cell maturation.	JARID2 ZBTB16	8.12e-06	4	41	2	25105474
Pubmed	BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62.	PPP2R1A CRYBG3 GARS1 SEC16A	3.47e-05	156	41	4	32850835
Pubmed	DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization.	PPP2R1A IARS1 GARS1 SEC16A	5.42e-05	175	41	4	25756610
Pubmed	Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies.	GARS1 PANK4 SEC16A	6.91e-05	67	41	3	30669930
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	GPATCH8 CENPF CDK13 SEC16A	8.58e-05	197	41	4	20811636
Pubmed	miRNAs control tracheal chondrocyte differentiation.	SOX6 SPEN	8.88e-05	12	41	2	21945074
Pubmed	Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells.	JARID2 PRDM14	1.05e-04	13	41	2	26523946
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	USP31 ALS2 GPATCH8 SPEN SEC16A	1.13e-04	407	41	5	12693553
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	KLF16 PPP2R1A GPATCH8 PQBP1 SPEN USP42 CENPF CDK13	1.15e-04	1294	41	8	30804502
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	USP31 GPATCH8 SPEN CDK13 SEC16A	1.31e-04	420	41	5	28065597
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	ALS2 CACNA1G BIRC6 SEC16A	1.43e-04	225	41	4	12168954
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	PPP2R1A PQBP1 SPEN CENPF RBM12B IARS1 SEC16A	1.76e-04	1024	41	7	24711643
Pubmed	Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.	PPP2R1A GPATCH8 PQBP1 RBM12B IARS1 GARS1	1.79e-04	714	41	6	28302793
Pubmed	Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.	PRPF38B PQBP1 USP42 RBM12B CLK2 CDK13	1.91e-04	723	41	6	34133714
Pubmed	The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.	JARID2 NIPSNAP3A NIPSNAP3B IARS1	1.98e-04	245	41	4	19521500
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	PRPF38B TBC1D30 CENPF BIRC6 IARS1 GARS1	2.11e-04	736	41	6	29676528
Pubmed	Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.	ALS2 ZBTB16 PQBP1 RBM12B PRDM14 CLK2	2.20e-04	742	41	6	26871637
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	PRPF38B CRYBG3 PQBP1 CENPF SEC16A	2.26e-04	472	41	5	38943005
Pubmed	The Antagonistic Gene Paralogs Upf3a and Upf3b Govern Nonsense-Mediated RNA Decay.	UPF3A ZBTB16	2.29e-04	19	41	2	27040500
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	PRPF38B GPATCH8 SPEN USP42 CDK13 SEC16A	2.76e-04	774	41	6	15302935
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	CASP1 PRPF38B PQBP1 SPEN CDK13 IARS1 GARS1	2.77e-04	1103	41	7	34189442
Pubmed	Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.	USP31 USP42	3.38e-04	23	41	2	14715245
Pubmed	Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.	SOX6 TNFRSF11A	4.67e-04	27	41	2	19801982
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	SOX6 JARID2 ZBTB16 PQBP1 SPEN PRDM14	5.35e-04	877	41	6	20211142
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	PPP2R1A CRYBG3 PQBP1 SPEN SEC16A	6.16e-04	588	41	5	38580884
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	CENPF IARS1 GARS1 SEC16A	6.25e-04	332	41	4	37433992
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	CIR1 PPP2R1A NIPSNAP3A PRPF38B BIRC6 IARS1 GARS1	7.30e-04	1297	41	7	33545068
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	KLF16 PRPF38B GPATCH8 PQBP1 BIRC6 CDK13 SEC16A	8.35e-04	1327	41	7	32694731
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	ALS2 CACNA1G PQBP1 BIRC6	8.71e-04	363	41	4	14691545
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	PPP2R1A SPEN CENPF BIRC6 SEC16A	9.85e-04	653	41	5	22586326
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	CIR1 PPP2R1A CDK13 IARS1 SEC16A	9.98e-04	655	41	5	35819319
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	KLF16 GPATCH8 USP42 CENPF RBM12B GARS1	1.00e-03	989	41	6	36424410
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	PPP2R1A GPATCH8 SPEN CDK13 IARS1	1.07e-03	665	41	5	30457570
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	CASP1 PPP2R1A PRPF38B GPATCH8 PQBP1 CDK13	1.14e-03	1014	41	6	32416067
Interaction	NANOG interactions	JARID2 PPP2R1A PRPF38B GPATCH8 USP42 CENPF PRDM14 SEC16A	4.75e-06	481	41	8	int:NANOG
Cytoband	9q31.1	NIPSNAP3A NIPSNAP3B	6.24e-04	41	41	2	9q31.1
GeneFamily	Ubiquitin specific peptidases	USP31 USP42	3.38e-03	56	28	2	366
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	KLF16 ZNF627 ZBTB16 PRDM14 ZNF596	4.48e-03	718	28	5	28
Computational	Neighborhood of DEAF1	UPF3A IARS1 GARS1	1.76e-04	57	21	3	MORF_DEAF1
Computational	Genes in the cancer module 133.	IARS1 GARS1	3.76e-04	15	21	2	MODULE_133
Computational	tRNA synthesis.	IARS1 GARS1	3.76e-04	15	21	2	MODULE_160
Computational	Genes in the cancer module 110.	IARS1 GARS1	4.29e-04	16	21	2	MODULE_110
Computational	Genes in the cancer module 35.	IARS1 GARS1	4.29e-04	16	21	2	MODULE_35
Disease	Microcephaly	PQBP1 CENPF IARS1	9.64e-05	67	39	3	C0025958
Disease	triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement	TYW1B GARS1 SEC16A	3.27e-03	225	39	3	EFO_0008317, EFO_0020947

Protein segments in the cluster

Peptide	Gene	Start	Entry
DKAVESLRAISHEHS	PPP2R1A	106	P30153
KHDHERDESSRSPAR	BAHCC1	1466	Q9P281
DSEEHSRSDSVTGHT	BIRC6	481	Q9NR09
RSESRTDLVHHFEKG	CRYBG3	2041	Q68DQ2
KLSDHSVREDSEHGE	ALS2	351	Q96Q42
SSRRAKSVEDDAEGH	CLK2	136	P49760
SRSRHSHSGEERAEV	CDK13	231	Q14004
SRERGDHSHLFDSKD	RBM12B	501	Q8IXT5
ESADSRAAGRHKSHE	NIPSNAP3A	201	Q9UFN0
SDELARHHRTHTGEK	KLF16	171	Q9BXK1
VDSSHTSGRLHEEAR	GPR179	911	Q6PRD1
HDEEHARARGLSEDT	ASPG	46	Q86U10
SRRHSKRSHDSDDSD	GPATCH8	901	Q9UKJ3
ESADSRAAGRHKSHE	NIPSNAP3B	201	Q9BS92
VRSFDHSGKDTEREH	PANK4	61	Q9NVE7
SHDKSDRGHDKSDRS	PQBP1	106	O60828
RGHDKSDRGHDKSDR	PQBP1	126	O60828
EAFAHRPEHKTSDST	CASP1	216	P29466
SDHRHRGSLEREAKS	CACNA1G	1156	O43497
EHTSETTERTPKHDV	CENPF	1676	P49454
VHDTHVRTRSDDSSR	CRISPLD1	266	Q9H336
SHESPSDTEEDDRKH	FOXN3	386	O00409
SQGKHEIAAEHSDRR	CCDC191	856	Q8NCU4
SDSRHLGTSEVDHER	SLC38A9	6	Q8NBW4
EKHSDHRADSRREQA	JARID2	251	Q92833
AHDSHVRRSHKEDDG	PRDM14	531	Q9GZV8
TSHSGSDKEHRDVER	UPF3A	336	Q9H1J1
EALTRHGVSHKVDDS	GARS1	636	P41250
SGAKISDLHRESVDH	IARS1	491	P41252
SREKEEGSDQHVASH	SOX6	26	P35712
SERKEGSSRSHGREE	CIR1	371	Q86X95
KRRHDSVENSDSHVE	USP42	1161	Q9H9J4
TESSDLRRHERTHTG	ZNF596	401	Q8TC21
SKEDALETHRQTHTG	ZBTB16	471	Q05516
DSDEDGEHKSHSPRA	SPEN	1381	Q96T58
EEVDRRSVHSEHSAR	SEC16A	1341	O15027
EHEATREDERKFTST	TEX37	91	Q96LM6
RSHKRDHSDSKDQSD	PRPF38B	506	Q5VTL8
ASSVRSHERTHTGEK	ZNF627	291	Q7L945
SGRHSKARDSDEEND	TBC1D30	546	Q9Y2I9
SDSHSRREHKAVGRA	USP31	926	Q70CQ4
HHRDTKEEEPFESSS	TYW1B	236	Q6NUM6
RVEHHGTEKSDAVCS	TNFRSF11A	181	Q9Y6Q6