Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-6 ERVK-7 ERVK-8 ERVK-18 ERVK-19 ERVK-25	5.09e-07	37	163	6	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-6 ERVK-7 ERVK-8 ERVK-18 ERVK-19 ERVK-25	6.00e-07	38	163	6	GO:0070001
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-6 ERVK-7 ERVK-8	8.40e-05	11	163	3	GO:0004523
GeneOntologyMolecularFunction	transmembrane transporter activity	GPM6A TRPM7 ABCA12 FLVCR1 HTR3E HTR3C ANO5 GRIK4 SLC7A14 SLC38A2 NALCN SV2B KCNJ13 ATP6V0A4 TRPV6 CACNA1H ABCC12 ABCC2 ATP1B2 SLC25A23 TRPV5 ATP6V0A2 SLC35B1	9.13e-05	1180	163	23	GO:0022857
GeneOntologyMolecularFunction	transporter activity	GPM6A TRPM7 ABCA12 FLVCR1 HTR3E HTR3C ANO5 ATP10B GRIK4 SLC7A14 SLC38A2 NALCN SV2B KCNJ13 ATP6V0A4 TRPV6 CACNA1H ABCC12 ABCC2 ATP1B2 SLC25A23 TRPV5 ATP6V0A2 SLC35B1	1.28e-04	1289	163	24	GO:0005215
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-6 ERVK-7 ERVK-8	1.82e-04	14	163	3	GO:0003964
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ABCA12 ATP6V0A4 ABCC12 ABCC2 ATP1B2 ATP6V0A2	2.73e-04	109	163	6	GO:0042626
GeneOntologyMolecularFunction	hydrolase activity, acting on ester bonds	ENPP6 ERVK-6 PDE1A NT5E PPM1E SAMHD1 ERVK-7 PLBD2 GDE1 PTPRO LIPM ERVK-8 CES3 PLA2G4A PDP2 ACSBG2 CNOT1	3.33e-04	807	163	17	GO:0016788
GeneOntologyMolecularFunction	ATP-dependent activity	ABCA12 SMCHD1 ATP10B INO80 SRCAP DNAH17 ATP6V0A4 HLTF ACSBG2 ABCC12 DDX60L ABCC2 ATP1B2 ATP6V0A2	5.25e-04	614	163	14	GO:0140657
GeneOntologyMolecularFunction	monoatomic cation channel activity	GPM6A TRPM7 HTR3E HTR3C GRIK4 NALCN KCNJ13 TRPV6 CACNA1H TRPV5	5.31e-04	343	163	10	GO:0005261
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-6 ERVK-7 ERVK-8	6.37e-04	21	163	3	GO:0035613
GeneOntologyMolecularFunction	serotonin-gated monoatomic cation channel activity	HTR3E HTR3C	6.52e-04	5	163	2	GO:0022850
GeneOntologyMolecularFunction	glycerophosphodiester phosphodiesterase activity	ENPP6 GDE1	9.72e-04	6	163	2	GO:0008889
GeneOntologyMolecularFunction	serotonin receptor activity	HTR3E HTR3C	9.72e-04	6	163	2	GO:0099589
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	GPM6A TRPM7 HTR3E HTR3C GRIK4 SLC38A2 NALCN KCNJ13 ATP6V0A4 TRPV6 CACNA1H ATP1B2 TRPV5 ATP6V0A2	1.12e-03	664	163	14	GO:0008324
Domain	Spectrin	SYNE1 SPTB DST DMD	3.85e-05	23	158	4	PF00435
Domain	ACTININ_2	SYNE1 SPTB DST DMD	3.85e-05	23	158	4	PS00020
Domain	ACTININ_1	SYNE1 SPTB DST DMD	3.85e-05	23	158	4	PS00019
Domain	Actinin_actin-bd_CS	SYNE1 SPTB DST DMD	3.85e-05	23	158	4	IPR001589
Domain	TRPV5/TRPV6	TRPV6 TRPV5	7.11e-05	2	158	2	IPR008344
Domain	Spectrin_repeat	SYNE1 SPTB DST DMD	9.93e-05	29	158	4	IPR002017
Domain	SPEC	SYNE1 SPTB DST DMD	1.47e-04	32	158	4	SM00150
Domain	Spectrin/alpha-actinin	SYNE1 SPTB DST DMD	1.47e-04	32	158	4	IPR018159
Domain	V_ATPase_I	ATP6V0A4 ATP6V0A2	4.22e-04	4	158	2	PF01496
Domain	V-type_ATPase_116kDa_su_euka	ATP6V0A4 ATP6V0A2	4.22e-04	4	158	2	IPR026028
Domain	V-ATPase_116kDa_su	ATP6V0A4 ATP6V0A2	4.22e-04	4	158	2	IPR002490
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	TRPM7 ANO5 ATP10B NALCN ATP6V0A4 TRPV6 ATP1B2 TRPV5 ATP6V0A2	2.33e-05	176	123	9	MM15718
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	TRPM7 ANO5 ATP10B NALCN ATP6V0A4 TRPV6 ATP1B2 TRPV5 ATP6V0A2	3.18e-05	183	123	9	M997
Pathway	WP_GPCRS_ODORANT	HCAR1 TAS2R38 GPR139 RHO ADGRG6 GPR158 GPR153 TAS2R50	6.90e-05	157	123	8	MM15872
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-7 ERVK-18 ERVK-19	2.55e-09	5	167	4	12629516
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	UNC13B HDAC5 DNAJC16 SYNE1 PPM1E DGKB ZDHHC17 CSMD3 PXDN SV2B DOCK7 DZIP3 KATNIP CACNA1H	1.23e-08	407	167	14	12693553
Pubmed	Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.	ERVK-6 ERVK-18 ERVK-19	1.09e-07	3	167	3	10516026
Pubmed	Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.	SYNE1 DST DNAH17 HEATR5B	2.34e-06	20	167	4	21689717
Pubmed	Global/temporal gene expression in diaphragm and hindlimb muscles of dystrophin-deficient (mdx) mice.	NEB TBC1D32 DMD	3.75e-06	7	167	3	12176734
Pubmed	Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects.	TRPM7 TRPV6 TRPV5	5.98e-06	8	167	3	33859252
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-6 ERVK-7 ERVK-8 ERVK-18 ERVK-19 ERVK-25	6.43e-06	94	167	6	21542922
Pubmed	Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship.	GPR139 GPR153 GPR148	8.94e-06	9	167	3	15777626
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SYNE1 DGKB ATP10B SERINC2 DST SV2B	9.74e-06	101	167	6	9872452
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	DNAJC16 SYNE1 NEB FER1L6 DST KIAA1549L DMD HERC1	1.88e-05	234	167	8	36243803
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SYNE1 SMCHD1 ATP10B SSR3 ZDHHC17 NEB SRCAP FER1L6 STT3B DST PXDN WDR75 RETREG1 CES3 DMD ABCC2 PLIN1 CDC27 PCK1 DOP1A	2.14e-05	1442	167	20	35575683
Pubmed	5-HT3 receptor influences the washing phenotype and visual organization in obsessive-compulsive disorder supporting 5-HT3 receptor antagonists as novel treatment option.	HTR3E HTR3C	2.29e-05	2	167	2	23928294
Pubmed	Alteration of calcium homeostasis in primary preeclamptic syncytiotrophoblasts: effect on calcium exchange in placenta.	TRPV6 TRPV5	2.29e-05	2	167	2	20178461
Pubmed	The TRPV5/6 calcium channels contain multiple calmodulin binding sites with differential binding properties.	TRPV6 TRPV5	2.29e-05	2	167	2	22354706
Pubmed	Diverse calcium channel types are present in the human placental syncytiotrophoblast basal membrane.	TRPV6 TRPV5	2.29e-05	2	167	2	16564089
Pubmed	Endogenous expression of TRPV5 and TRPV6 calcium channels in human leukemia K562 cells.	TRPV6 TRPV5	2.29e-05	2	167	2	19295174
Pubmed	Human TRPV5 and TRPV6: key players in cadmium and zinc toxicity.	TRPV6 TRPV5	2.29e-05	2	167	2	23968883
Pubmed	USP13 enzyme regulates Siah2 ligase stability and activity via noncatalytic ubiquitin-binding domains.	USP13 SIAH2	2.29e-05	2	167	2	21659512
Pubmed	Expression of calcium channels along the differentiation of cultured trophoblast cells from human term placenta.	TRPV6 TRPV5	2.29e-05	2	167	2	12390878
Pubmed	TRPV5 and TRPV6 are expressed in placenta and bone tissues during pregnancy in mice.	TRPV6 TRPV5	2.29e-05	2	167	2	30916584
Pubmed	Interaction of the epithelial Ca2+ channels TRPV5 and TRPV6 with the intestine- and kidney-enriched PDZ protein NHERF4.	TRPV6 TRPV5	2.29e-05	2	167	2	16565876
Pubmed	Age-dependent alterations in Ca2+ homeostasis: role of TRPV5 and TRPV6.	TRPV6 TRPV5	2.29e-05	2	167	2	16705151
Pubmed	Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1.	SYNE1 CSMD1	2.29e-05	2	167	2	24387768
Pubmed	Expression of transient receptor potential vanilloid channels TRPV5 and TRPV6 in retinal pigment epithelium.	TRPV6 TRPV5	2.29e-05	2	167	2	20405023
Pubmed	A single amino acid mutation results in a rapid inactivation of epithelial calcium channels.	TRPV6 TRPV5	2.29e-05	2	167	2	11846401
Pubmed	Expression and prognostic roles of TRPV5 and TRPV6 in non-small cell lung cancer after curative resection.	TRPV6 TRPV5	2.29e-05	2	167	2	24761864
Pubmed	Fast and slow inactivation kinetics of the Ca2+ channels ECaC1 and ECaC2 (TRPV5 and TRPV6). Role of the intracellular loop located between transmembrane segments 2 and 3.	TRPV6 TRPV5	2.29e-05	2	167	2	12077127
Pubmed	Regulation of Dyrk1A kinase activity by 14-3-3.	DYRK1A YWHAE	2.29e-05	2	167	2	15369779
Pubmed	[The functional characteristics oF TRPV5 and TRPV6 channels in normal and transformed human blood lymphocytes].	TRPV6 TRPV5	2.29e-05	2	167	2	24592736
Pubmed	TRPM7 and CaV3.2 channels mediate Ca2+ influx required for egg activation at fertilization.	TRPM7 CACNA1H	2.29e-05	2	167	2	30322909
Pubmed	Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6.	TRPV6 TRPV5	2.29e-05	2	167	2	12574114
Pubmed	Structural conservation of the genes encoding CaT1, CaT2, and related cation channels.	TRPV6 TRPV5	2.29e-05	2	167	2	11549322
Pubmed	[TRPV5 and TRPV6 calcium channels in human T cells].	TRPV6 TRPV5	2.29e-05	2	167	2	19140341
Pubmed	Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.	ERVK-6 ERVK-19	2.29e-05	2	167	2	9060628
Pubmed	Upregulation of p300 in paclitaxel-resistant TNBC: implications for cell proliferation via the PCK1/AMPK axis.	EP300 PCK1	2.29e-05	2	167	2	38378770
Pubmed	Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.	ERVK-6 ERVK-19	2.29e-05	2	167	2	9460924
Pubmed	First evidence of TRPV5 and TRPV6 channels in human parathyroid glands: possible involvement in neoplastic transformation.	TRPV6 TRPV5	2.29e-05	2	167	2	25164318
Pubmed	Bitter Taste Receptors and Chronic Otitis Media.	TAS2R38 TAS2R50	2.29e-05	2	167	2	33433247
Pubmed	Targeting tetramer-forming GABPβ isoforms impairs self-renewal of hematopoietic and leukemic stem cells.	GABPB2 GABPB1	2.29e-05	2	167	2	22862946
Pubmed	The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance.	HTR3E HTR3C	2.29e-05	2	167	2	15157181
Pubmed	Regulation of the mouse epithelial Ca2(+) channel TRPV6 by the Ca(2+)-sensor calmodulin.	TRPV6 TRPV5	2.29e-05	2	167	2	15123711
Pubmed	Single-channel activities of the human epithelial Ca2+ transport proteins CaT1 and CaT2.	TRPV6 TRPV5	2.29e-05	2	167	2	11719848
Pubmed	Concerted action of associated proteins in the regulation of TRPV5 and TRPV6.	TRPV6 TRPV5	2.29e-05	2	167	2	17233615
Pubmed	Purification and assay of the human INO80 and SRCAP chromatin remodeling complexes.	INO80 SRCAP	2.29e-05	2	167	2	17101442
Pubmed	Interferon-alpha-induced endogenous superantigen. a model linking environment and autoimmunity.	ERVK-6 ERVK-18	2.29e-05	2	167	2	11672541
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-6 ERVK-8 ERVK-19	2.32e-05	12	167	3	14557543
Pubmed	The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion.	CERS2 TRPM7 DNAJC16 STT3B SLC38A2 NBAS ATP6V0A2	2.42e-05	176	167	7	28692057
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	ENPP6 GPM6A DNAJC13 MXRA5 NT5E SERINC2 NEB YWHAE TSPAN3 TIAM2 FAH PTPRO UBAC1 ATP6V0A4 PCK1 PCYOX1	3.40e-05	1016	167	16	19056867
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	DNAJC13 TRPM7 DNAJC16 STT3B SLC38A2 NBAS DST RETREG1 FLCN SEC61B HEATR5B	3.52e-05	504	167	11	34432599
Pubmed	Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4.	TRPM7 DNAJC16 STT3B DST SLITRK5 SEC61B PLA2G4A	4.07e-05	191	167	7	31177093
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	DNAJC13 SMCHD1 STT3B NBAS PXDN DOCK7 CNOT1	5.81e-05	202	167	7	33005030
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	CERS2 DNAJC13 TRPM7 APEH SIAH2 SLC38A2 TM9SF2 HLTF CDC27 CNOT1 EP300	5.82e-05	533	167	11	25544563
Pubmed	LncMyoD Promotes Skeletal Myogenesis and Regulates Skeletal Muscle Fiber-Type Composition by Sponging miR-370-3p.	ACADSB DMD	6.85e-05	3	167	2	33920575
Pubmed	Identification of two new members of the CSMD gene family.	CSMD3 CSMD1	6.85e-05	3	167	2	12906867
Pubmed	Lack of pendrin HCO3- transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channels.	TRPV6 TRPV5	6.85e-05	3	167	2	17200157
Pubmed	Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E.	HTR3E HTR3C	6.85e-05	3	167	2	21192076
Pubmed	Age-dependent changes in the expression of klotho protein, TRPV5 and TRPV6 in mouse inner ear.	TRPV6 TRPV5	6.85e-05	3	167	2	19922080
Pubmed	Identification of BSPRY as a novel auxiliary protein inhibiting TRPV5 activity.	TRPV6 TRPV5	6.85e-05	3	167	2	16380433
Pubmed	Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E.	HTR3E HTR3C	6.85e-05	3	167	2	12801637
Pubmed	A molecular determinant of phosphoinositide affinity in mammalian TRPV channels.	TRPV6 TRPV5	6.85e-05	3	167	2	27291418
Pubmed	Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport.	TRPV6 TRPV5	6.85e-05	3	167	2	16763551
Pubmed	Direct interaction with Rab11a targets the epithelial Ca2+ channels TRPV5 and TRPV6 to the plasma membrane.	TRPV6 TRPV5	6.85e-05	3	167	2	16354700
Pubmed	Aciculin and its relation to dystrophin: immunocytochemical studies in human normal and Duchenne dystrophy quadriceps muscles.	SPTB DMD	6.85e-05	3	167	2	10867799
Pubmed	Cigarette smoke extract regulates cytosolic phospholipase A2 expression via NADPH oxidase/MAPKs/AP-1 and p300 in human tracheal smooth muscle cells.	PLA2G4A EP300	6.85e-05	3	167	2	21268080
Pubmed	Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein.	SRCAP EP300	6.85e-05	3	167	2	10347196
Pubmed	TRPV6, TRPM6 and TRPM7 Do Not Contribute to Hair-Cell Mechanotransduction.	TRPM7 TRPV6	6.85e-05	3	167	2	29515374
Pubmed	A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function.	EP300 GABPB1	6.85e-05	3	167	2	25200183
Pubmed	Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.	UBR1 SAMHD1 STT3B NF1 TM9SF2 DZIP3 COG5 EP300	7.22e-05	283	167	8	21903422
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	SYNE1 PPM1E YWHAE TIAM2 DST DMD	9.39e-05	151	167	6	17043677
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	CERS2 PDE1A GAK TRPM7 SSR3 STT3B SLC38A2 NBAS DST RETREG1 PLA2G4A	1.02e-04	568	167	11	37774976
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DNAJC13 DCAF8 FLVCR1 SPTB YWHAE PLBD2 GDE1 ADGRG6 PXDN ZNF827 GPR158 KATNIP CACNA1H RAPGEF2 CSMD1 CNOT1 ALG12 EP300 DOP1A	1.05e-04	1489	167	19	28611215
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	DCAF8 HDAC5 SMCHD1 SNX33 INO80 YWHAE NF1 GPR158 DZIP3 RAPGEF2	1.08e-04	475	167	10	31040226
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	HDAC5 DNAJC16 SYNE1 HEPH TTC7A DST GPR158	1.14e-04	225	167	7	12168954
Pubmed	Skp2-Mediated Stabilization of MTH1 Promotes Survival of Melanoma Cells upon Oxidative Stress.	UBR1 NT5E HERC1 CDC27	1.16e-04	52	167	4	28947420
Pubmed	A human MAP kinase interactome.	SYNE1 ZDHHC17 NEB YWHAE DST KIAA1549L DMD RAPGEF2 COG5 EP300	1.30e-04	486	167	10	20936779
Pubmed	Adenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcription.	SRCAP EP300	1.37e-04	4	167	2	11581372
Pubmed	Utility of molecular testing for related retinal dystrophies.	RHO USH2A	1.37e-04	4	167	2	16767206
Pubmed	A cluster of novel serotonin receptor 3-like genes on human chromosome 3.	HTR3E HTR3C	1.37e-04	4	167	2	14597179
Pubmed	The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells.	CYP11A1 EP300	1.37e-04	4	167	2	12101186
Pubmed	Roles of STAT3/SOCS3 pathway in regulating the visual function and ubiquitin-proteasome-dependent degradation of rhodopsin during retinal inflammation.	UBR1 RHO	1.37e-04	4	167	2	18614536
Pubmed	Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex.	TRPV6 TRPV5	1.37e-04	4	167	2	12660155
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-6 ERVK-7	1.37e-04	4	167	2	10469592
Pubmed	Cloning and characterization of mouse ACF7, a novel member of the dystonin subfamily of actin binding proteins.	DST DMD	1.37e-04	4	167	2	8954775
Pubmed	Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 protein-mediated modulation of p300 protein.	DMD EP300	1.37e-04	4	167	2	23297412
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-19	1.37e-04	4	167	2	7983737
Pubmed	Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions.	EP300 PCK1	1.37e-04	4	167	2	30193097
Pubmed	Testin and filamin-C downregulation by acetylated Siah2 increases invasiveness of Helicobacter pylori-infected gastric cancer cells.	SIAH2 EP300	1.37e-04	4	167	2	30063986
Pubmed	Differential localization of vacuolar H+-ATPases containing a1, a2, a3, or a4 (ATP6V0A1-4) subunit isoforms along the nephron.	ATP6V0A4 ATP6V0A2	1.37e-04	4	167	2	17595521
Pubmed	Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation.	EP300 PCK1	1.37e-04	4	167	2	28240261
Pubmed	Multiple Isoforms of Nesprin1 Are Integral Components of Ciliary Rootlets.	SYNE1 RHO	1.37e-04	4	167	2	28625779
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	CERS2 NELFA SYNE1 YWHAE TSPAN3 GDE1 DST TM9SF2 RETREG1 CACNA1H ATP6V0A2 SLC35B1	1.49e-04	697	167	12	28298427
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	CERS2 DNAJC13 DNAJC16 SSR3 STT3B SLC38A2 TM9SF2 SEC61B EP300 PCYOX1	1.61e-04	499	167	10	22810586
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	CPA5 ABCA12 SMCHD1 NEB CSMD3 YWHAE GREB1L DST WDR75 CACNA1H	2.01e-04	513	167	10	25798074
Pubmed	Mapping the expression of transient receptor potential channels across murine placental development.	TRPM7 TRPV6 TRPV5	2.04e-04	24	167	3	33884443
Pubmed	Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E.	HTR3E HTR3C	2.27e-04	5	167	2	17392525
Pubmed	Pharmacokinetics of mycophenolate mofetil and its glucuronide metabolites in healthy volunteers.	UGT1A7 ABCC2	2.27e-04	5	167	2	18597651
Pubmed	Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors.	SIAH2 EP300	2.27e-04	5	167	2	20609350
Pubmed	Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.	ERVK-6 ERVK-7	2.27e-04	5	167	2	11401426
Pubmed	Identification of a novel protein interaction between Elmo1 and Cdc27.	ELMO2 CDC27	2.27e-04	5	167	2	26882976
Pubmed	Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1.	HDAC5 EP300	2.27e-04	5	167	2	19071119
GeneFamily	5-hydroxytryptamine receptors, ionotropic	HTR3E HTR3C	3.56e-04	5	109	2	172
GeneFamily	Transient receptor potential cation channels	TRPM7 TRPV6 TRPV5	6.26e-04	28	109	3	249
CoexpressionAtlas	dev gonad_e11.5_F_SupCellPrec_Sry_k-means-cluster#2_top-relative-expression-ranked_1000	B3GALT1 PDE1A ACADSB CYP11A1 STT3B GREB1L SLC38A2 PLA2G4A	5.34e-07	97	154	8	gudmap_dev gonad_e11.5_F_SupCellPrec_Sry_k2_1000
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	ACADSB SYNE1 GRIK4 CSMD3 DST CDH20 NALCN DZIP3 SLITRK5 HERC1	9.99e-10	177	161	10	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 ABCA12 DGKB ANO5 NEB CSMD3 DMD CSMD1 USH2A	2.46e-08	184	161	9	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 ABCA12 DGKB ANO5 NEB CSMD3 DMD CSMD1 USH2A	2.46e-08	184	161	9	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 ABCA12 DGKB ANO5 NEB CSMD3 DMD CSMD1 USH2A	2.46e-08	184	161	9	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	DGKB GRIK4 CSMD3 GREB1L GPR158 DMD CSMD1 USH2A	1.21e-07	159	161	8	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ENPP6 GPM6A DGKB GPR153 ABCC2 CSMD1 TTC38 PCK1	2.75e-07	177	161	8	2f81b26be89cc2fd8eafadaf7eae3c6ad6521462
ToppCell	droplet-Trachea-3m-Epithelial-airway_epithelial-neuroendocrine_cell-neuroendocrine\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PDE1A PPM1E DGKB CDH20 CACNA1H DMD CSMD1 ATP1B2	4.91e-07	191	161	8	72f1ddc09080dbfea8d51294cbf7f9d4925f9cc0
ToppCell	droplet-Trachea-3m-Epithelial-airway_epithelial-neuroendocrine_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PDE1A PPM1E DGKB CDH20 CACNA1H DMD CSMD1 ATP1B2	4.91e-07	191	161	8	6e7f589efc997f32175e0789c5ea7ca46e1389b8
ToppCell	droplet-Trachea-nan-3m-Epithelial-neuroendocrine_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE1A PPM1E DGKB CDH20 CACNA1H DMD CSMD1 ATP1B2	4.91e-07	191	161	8	3ce403e0beedb544edeb3ae6eb30267040d00c21
ToppCell	Transverse-Macrophage-LYVE1_Macrophage\|Macrophage / Region, Cell class and subclass	CERS2 AOC1 NT5E DNAJC16 TSPAN3 SLC38A2 PLA2G4A SIGLEC1	6.70e-07	199	161	8	fd75dccb37d96448edf72b7d042b06833d4ead24
ToppCell	droplet-Lung-nan-18m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE1A GRIK4 NXNL2 ZNF827 SLITRK5 CSMD1 ATP1B2	5.26e-06	186	161	7	b58db5abdd3e9f0214b198c3cbd09b0b3c321eab
ToppCell	droplet-Lung-nan-18m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE1A GRIK4 NXNL2 ZNF827 SLITRK5 CSMD1 ATP1B2	5.26e-06	186	161	7	cd6502bbf9dce318fdbb4965d49df8951e5f795c
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HTR3C CSMD3 MROH2B ACSBG2 ABCC12 ABCC2 USH2A	6.69e-06	193	161	7	315840bc48899f3a36d57b19197509de19716e3d
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	UNC13B GPM6A CSMD3 KIAA1549L SV2B CSMD1 DPY19L2P1	7.16e-06	195	161	7	2e1df01bf6e4e98e6cd9fb50926e34c5077b8666
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SYNE1 DGKB CSMD3 KIAA1549L GPR158 CSMD1 DPY19L2P1	7.91e-06	198	161	7	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	DYRK1A NBAS NF1 DMD HERC1 RAPGEF2 COG5	8.17e-06	199	161	7	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	BL-critical-LOC-Epithelial-FOXN4+\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	USP13 NT5E PPM1E HTR3E FER1L6 SERPINB10	2.57e-05	160	161	6	3f737451d5713deed20061aa72a9ef77a9a2bc06
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NEB CSMD3 KIAA1549L SIGLEC1 ABCC2 USH2A	2.76e-05	162	161	6	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	COVID-19-kidney-Technical/muscle_(Imm)\|kidney / Disease (COVID-19 only), tissue and cell type	ENTHD1 GRIK4 CSMD3 GREB1L DMD USH2A	2.86e-05	163	161	6	19c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCell	P15-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GPM6A USP13 GAK NT5E DNAJC16 HEATR5B	3.27e-05	167	161	6	5c3d0763f73628c71c71f9883556bb4f1639f3cc
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HTR3E HTR3C RHO ADGRG6 PLA2G4A CSMD1	3.38e-05	168	161	6	8072d0496b7b730c4601009eaa69ec5366d26d73
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ENPP6 NXNL2 FAM135B CES3 ABCC2 PCK1	3.38e-05	168	161	6	fa0d251693935116adf633d02b7ec4a295100865
ToppCell	droplet-Lung-18m-Hematologic-myeloid-intermediate_monocyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SAMHD1 TIAM2 TTC7A SERPINB10 PTPRO ELMO2	3.38e-05	168	161	6	00cff4698db14e03ca1d1b409e5ed1ad23b12615
ToppCell	facs-Heart-RA-18m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B ENPP6 GPM6A ADGRG6 GREB1L KIAA1549L	3.38e-05	168	161	6	06dc5b2d356d3a9454b10bba6f3b9ead2a0a7d46
ToppCell	facs-Heart-RA-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B ENPP6 GPM6A ADGRG6 GREB1L KIAA1549L	3.38e-05	168	161	6	1002f058a340763e3d8de0bd1f0547a903526ec6
ToppCell	droplet-Lung-18m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l4\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SAMHD1 TIAM2 TTC7A SERPINB10 PTPRO ELMO2	3.50e-05	169	161	6	90c00ab30e582b0e2a2be751e1fae9024cfb9ea6
ToppCell	PND10-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLVCR1 HCAR1 TIAM2 SERPINB10 CEP70 ALG12	3.62e-05	170	161	6	7534ac69ca3a378df78d61c284e89bc96a71a4a8
ToppCell	AT1-AT2_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	HCAR1 ADGRG6 PXDN TRPV6 CACNA1H PSAPL1	3.86e-05	172	161	6	0be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCell	droplet-Marrow-nan-24m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B GPM6A SERINC2 RASIP1 C2 CACNA1H	4.12e-05	174	161	6	cdfc50e5383c8670ce5109736aff36406f46c03d
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP13 CYP11A1 CSMD3 RHO ATP6V0A4 ATP1B2	4.25e-05	175	161	6	59249c9e83952d7277010e7be3c779e26399eb5d
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP13 CYP11A1 CSMD3 RHO ATP6V0A4 ATP1B2	4.25e-05	175	161	6	b35cc1357495f2a03a6500f807c6e6f8c877734d
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PDE1A RHO CDH20 ABCC12 DMD ATP1B2	4.97e-05	180	161	6	b7513b9816a9cb9f3caaddb2a9fed0be1c7f9805
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PDE1A RHO CDH20 ABCC12 DMD ATP1B2	4.97e-05	180	161	6	f96c5be4705e3d338c0393d2885ac8d5beccd6fd
ToppCell	wk_20-22-Hematologic-Meg-ery-Definitive_erythroblast\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	SPTB UBAC1 FLCN HERC1 RAPGEF2 EP300	5.29e-05	182	161	6	0c77ef4556c1d1512ebe9077df858b28f9e38dd5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ENPP6 GPM6A DGKB CSMD1 TTC38 PCK1	5.45e-05	183	161	6	85446581999cd66b171c4f69b7eb8b0bbbaa8617
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B GPM6A SERINC2 RASIP1 CACNA1H CSMD1	5.62e-05	184	161	6	1e54fd372c6e6a298f427b807c14cc49aaaffe80
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE1A SYNE1 SERINC2 DMD CSMD1 ATP1B2	5.96e-05	186	161	6	4780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ENPP6 DGKB ABCC2 CSMD1 TTC38 PCK1	5.96e-05	186	161	6	a417e1e21313a7e05951038cdef5ac672a9f727c
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PDE1A GRIK4 ZNF827 SLITRK5 CSMD1 ATP1B2	6.14e-05	187	161	6	8bd635abdee5d5a12a3f7bf74eab4282e8e40741
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PDE1A GRIK4 ZNF827 SLITRK5 CSMD1 ATP1B2	6.14e-05	187	161	6	3cb8cd7f7a4306ff74d1f7f9964014008ec1c6a0
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	TRPM7 SMCHD1 DYRK1A NF1 HERC1 RAPGEF2	6.33e-05	188	161	6	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|LV / Chamber and Cluster_Paper	TRPM7 ANO5 GREB1L DST RETREG1 DMD	6.91e-05	191	161	6	25f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCell	Mesenchymal-vascular_smooth_muscle_cell\|World / Lineage, Cell type, age group and donor	SPTB DGKB PXDN CACNA1H DMD CSMD1	6.91e-05	191	161	6	fd89fbc62aa1c73e0f659991e3bd726a0c97bd68
ToppCell	droplet-Trachea-nan-3m-Mesenchymal-smooth_muscle_cell_of_trachea\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE1A PPM1E DGKB C2 DMD ATP1B2	7.11e-05	192	161	6	a804cb101c3a5585f72217e1143584b1ca436724
ToppCell	droplet-Spleen-nan-18m-Lymphocytic-plasma_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPM6A SSR3 RASIP1 CACNA1H TMEM39A SLC35B1	7.11e-05	192	161	6	6417468829517a0f6e04e7e44eec1622001d4c5c
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l39\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PDE1A PPM1E DGKB C2 DMD ATP1B2	7.31e-05	193	161	6	d0dcc0c11ccf99ff6b07e456d25b9742649aadd8
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A MXRA5 SERINC2 ADGRG6 GREB1L TRPV6	7.53e-05	194	161	6	4579b4a44f7c731553a284843c296866027d7c0e
ToppCell	COVID-19-Heart-CM_1\|Heart / Disease (COVID-19 only), tissue and cell type	USP13 ANO5 GREB1L NALCN RETREG1 DMD	7.74e-05	195	161	6	f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SYNE1 CSMD3 KIAA1549L GPR158 CSMD1 DPY19L2P1	7.96e-05	196	161	6	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	proximal-Endothelial-Lymphatic\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GPM6A PDE1A PTCHD3 NT5E RASIP1 SV2B	8.19e-05	197	161	6	8835961bd734a86063fd854cd2fb7028aefb7a72
ToppCell	proximal-Endothelial-Lymphatic-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GPM6A PDE1A PTCHD3 NT5E RASIP1 SV2B	8.19e-05	197	161	6	8d79e747e344656e2bfc7fe872b4430dca941196
ToppCell	proximal-3-Endothelial-Lymphatic\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	GPM6A PDE1A PTCHD3 NT5E RASIP1 SV2B	8.19e-05	197	161	6	1c64e4eb9bfbaf5d6b4349642858f83a00d4d4c6
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GPM6A SYNE1 CSMD3 KIAA1549L CSMD1 DPY19L2P1	8.42e-05	198	161	6	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SYNE1 CSMD3 KIAA1549L GPR158 CSMD1 DPY19L2P1	8.42e-05	198	161	6	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GPM6A SYNE1 CSMD3 KIAA1549L CSMD1 DPY19L2P1	8.42e-05	198	161	6	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	UNC13B DYRK1A NF1 DMD RAPGEF2 COG5	8.42e-05	198	161	6	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CSMD3 KIAA1549L GPR158 HERC1 CSMD1 DPY19L2P1	8.42e-05	198	161	6	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	SYNE1 CSMD3 KIAA1549L HERC1 CSMD1 DPY19L2P1	8.90e-05	200	161	6	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal-Intermediate\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	MXRA5 CSMD3 CES3 DDX60L USH2A RFPL2	8.90e-05	200	161	6	fe772d98c461c973dfc082e1fc50117c27ced804
ToppCell	LPS-antiTNF-Myeloid-Dendritic_cells-Monocytes-Macrophages\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PPM1E PLBD2 FAM135B LIPM SIGLEC1	1.02e-04	128	161	5	cfc73cb803ba50a4a8709e19e70e1e399118c849
Disease	response to carboplatin	PDE1A NBAS ZNF827 GPR158 MRGBP ABCC2	7.15e-07	58	159	6	GO_0097328
Disease	Colorectal Carcinoma	UNC13B TRPM7 ABCA12 SYNE1 PPM1E HTR3C CSMD3 NF1 FLCN DMD ABCC2 EP300 GABPB1	1.18e-04	702	159	13	C0009402
Disease	diet measurement	B3GALT1 HTR3E SAMHD1 TAS2R38 RASIP1 NBAS DST NF1 CDH20 NALCN CACNA1H CSMD1 CNOT1 PCK1 DPY19L2P1 RAB33B	1.83e-04	1049	159	16	EFO_0008111
Disease	autosomal recessive osteopetrosis 1 (implicated_via_orthology)	ATP6V0A4 ATP6V0A2	2.85e-04	5	159	2	DOID:0110942 (implicated_via_orthology)
Disease	neuropsychological test	PPM1E GRIK4 FAM135B FER1L6 TBC1D32 CSMD1	7.19e-04	197	159	6	EFO_0003926
Disease	HOMA-IR	UBXN11 PTPRO CSMD1	7.44e-04	33	159	3	EFO_0004501
Disease	Colorectal Neoplasms	TRPM7 ABCA12 SYNE1 PPM1E FLCN ABCC2 EP300	7.90e-04	277	159	7	C0009404
Disease	renal tubular acidosis (implicated_via_orthology)	ATP6V0A4 ATP6V0A2	7.91e-04	8	159	2	DOID:14219 (implicated_via_orthology)
Disease	metabolite measurement	AOC1 DNAJC16 UGT1A7 BCO1 SLC38A2 NBAS DMD ABCC2 CSMD1 TTC38	9.59e-04	560	159	10	EFO_0004725
Disease	temporal pole volume measurement	GPR158 PTPRO	1.84e-03	12	159	2	EFO_0010334
Disease	serum metabolite measurement	ENPP6 AOC1 NT5E DNAJC16 UGT1A7 GRIK4 BCO1 SLC38A2 DNAH17 DOCK7 PLA2G4A ABCC2 CSMD1	1.88e-03	945	159	13	EFO_0005653
Disease	sciatic neuropathy (biomarker_via_orthology)	CERS2 CYP11A1 NF1 CACNA1H	2.05e-03	99	159	4	DOID:11446 (biomarker_via_orthology)
Disease	status epilepticus (biomarker_via_orthology)	NT5E CYP11A1 DMD ABCC2	2.13e-03	100	159	4	DOID:1824 (biomarker_via_orthology)
Disease	FVC change measurement, response to placebo	DGKB KATNIP	2.16e-03	13	159	2	EFO_0008344, EFO_0010339
Disease	serum IgG glycosylation measurement	GPM6A DYRK1A ENTHD1 GPR139 PXDN GPR158 FLCN CSMD1 USH2A	2.20e-03	523	159	9	EFO_0005193
Disease	Retinitis Pigmentosa	FLVCR1 SLC7A14 RHO USH2A	2.46e-03	104	159	4	C0035334
Disease	Down syndrome (implicated_via_orthology)	DYRK1A DOP1A	2.89e-03	15	159	2	DOID:14250 (implicated_via_orthology)
Disease	creatinine measurement	CERS2 PLAC1 PDE1A DNAJC13 DNAJC16 SERINC2 INO80 NEB FAM135B RASIP1 CDH20 DOCK7 PCK1	2.94e-03	995	159	13	EFO_0004518
Disease	neuritic plaque measurement	GRIK4 FAM135B BCO1 SV2B MROH2B RETREG1 CSMD1	2.94e-03	349	159	7	EFO_0006798
Disease	Autistic Disorder	ACADSB HTR3C CSMD3 NF1 PLA2G4A CACNA1H	2.99e-03	261	159	6	C0004352
Disease	Respiratory Distress Syndrome, Adult	LIM2 CES3 PLA2G4A	3.28e-03	55	159	3	C0035222
Disease	vision disorder	ANO5 PXDN	3.29e-03	16	159	2	MONDO_0021084
Disease	ankle brachial index	NBAS DMD	3.29e-03	16	159	2	EFO_0003912
Disease	Drug habituation	SYNE1 CSMD3 TIAM2 CSMD1	3.53e-03	115	159	4	C0013170
Disease	Drug abuse	SYNE1 CSMD3 TIAM2 CSMD1	3.53e-03	115	159	4	C0013146
Disease	Prescription Drug Abuse	SYNE1 CSMD3 TIAM2 CSMD1	3.53e-03	115	159	4	C4316881
Disease	Substance-Related Disorders	SYNE1 CSMD3 TIAM2 CSMD1	3.53e-03	115	159	4	C0236969
Disease	Drug Use Disorders	SYNE1 CSMD3 TIAM2 CSMD1	3.53e-03	115	159	4	C0013222
Disease	Drug Dependence	SYNE1 CSMD3 TIAM2 CSMD1	3.53e-03	115	159	4	C1510472
Disease	Substance Dependence	SYNE1 CSMD3 TIAM2 CSMD1	3.53e-03	115	159	4	C0038580
Disease	Substance Use Disorders	SYNE1 CSMD3 TIAM2 CSMD1	3.53e-03	115	159	4	C0038586
Disease	Organic Mental Disorders, Substance-Induced	SYNE1 CSMD3 TIAM2 CSMD1	3.53e-03	115	159	4	C0029231
Disease	Substance abuse problem	SYNE1 CSMD3 TIAM2 CSMD1	3.64e-03	116	159	4	C0740858
Disease	Moyamoya Disease	SAMHD1 NF1	3.72e-03	17	159	2	C0026654
Disease	X-21441 measurement	UGT1A7 ABCC2	3.72e-03	17	159	2	EFO_0800814
Disease	phosphatidylcholine 40:6 measurement	RAPGEF2 CSMD1	3.72e-03	17	159	2	EFO_0010389
Disease	creatinine measurement, glomerular filtration rate	CERS2 DNAJC16 INO80 CDH20	3.75e-03	117	159	4	EFO_0004518, EFO_0005208
Disease	serum gamma-glutamyl transferase measurement	UBR1 TRPM7 DNAJC16 UGT1A7 DYRK1A CSMD3 RASIP1 NF1 ZNF827 SIGLEC1 ABCC2 CSMD1	4.07e-03	914	159	12	EFO_0004532
Disease	protein-glutamine gamma-glutamyltransferase e measurement	PXDN ZNF827 SIGLEC1	4.20e-03	60	159	3	EFO_0020690
Disease	lean body mass	CERS2 TRPM7 GPR139 ADGRG6 SLC38A2 C2 SLC25A23	4.60e-03	379	159	7	EFO_0004995
Disease	response to methotrexate, juvenile idiopathic arthritis	ENTHD1 CSMD1	4.65e-03	19	159	2	EFO_0002609, GO_0031427
Disease	sensorineural hearing loss (implicated_via_orthology)	SLC7A14 DNAH17	4.65e-03	19	159	2	DOID:10003 (implicated_via_orthology)
Disease	fish consumption measurement	DGKB NF1 CNOT1	5.03e-03	64	159	3	EFO_0010139
Disease	CCL5 measurement	AOC1 SYNE1 FAM135B	5.03e-03	64	159	3	EFO_0005117
Disease	alpha-tocopherol measurement	DYRK1A USH2A	5.14e-03	20	159	2	EFO_0007898

Protein segments in the cluster

Peptide	Gene	Start	Entry
QEIMMHVIWAALAFA	TSPAN3	206	O60637
LPLSHIAAQMMDIWV	ACSBG2	271	Q5FVE4
MQLLRDNLTLWTSDM	YWHAE	221	P62258
RAQWSTMCMLVELHT	EP300	1646	Q09472
TVIWMGDRLMTLEHH	ERVK-18	421	O42043
QTVIWMGDRLMSLEH	ERVK-19	531	O71037
QTVIWMGDRLMSLEH	ERVK-8	531	Q902F8
WHVLAAKMTFIIVME	ANO5	826	Q75V66
DLIVSMSNQMWLHLQ	CSMD1	491	Q96PZ7
VPDLIVSMSSQMWLH	CSMD3	626	Q7Z407
HDWFVSSLFMIMLGD	TBC1D32	1066	Q96NH3
VELWLQFSHAMDAML	HTR3E	421	A5X5Y0
EWMDKSPLFMNSFHL	ABCA12	841	Q86UK0
LLATFTWMGLEAIHM	ADGRG6	941	Q86SQ4
ISPEEMHRIWNDMSS	B3GALT1	306	Q9Y5Z6
LMELWVQFSHAMDTL	HTR3C	411	Q8WXA8
MWISSAEHAGLFLVM	ACADSB	206	P45954
HMIMSSVTLLWSILH	DOP1A	1766	Q5JWR5
SCVNHWRAIMDNLMT	DOP1A	2126	Q5JWR5
WRAIMDNLMTHDKTT	DOP1A	2131	Q5JWR5
SLQKDLSEMHEWMTQ	DMD	1161	P11532
AIDMWSLGCILVEMH	DYRK1A	341	Q13627
WAVAAILMLQTAMAE	AOC1	6	P19801
NSMMGVLQLLHIFWA	CERS2	306	Q96G23
LTTILLHQAMEMKTW	ATP10B	1236	O94823
VATMFCWVTAMQFHL	ALG12	126	Q9BV10
LMLWMANTTELLSFV	RASIP1	646	Q5U651
MTNMASFHSLPSWIE	RAB33B	116	Q9H082
LTHSWLMSLADLQDM	PADI1	166	Q9ULC6
HINMMELFSISKEFW	PCK1	571	P35558
IVWSCHLMATASAMA	H2BW1	16	Q7Z2G1
NHAIMGVAFTWVMAL	RHO	151	P08100
NTMAELWALLHFIMP	INO80	686	Q9ULG1
NTISLSEIMNMLWHR	ENTHD1	46	Q8IYW4
HLSSLEWEMTFRTKM	DPY19L2P1	131	Q6NXN4
TILLVVAMATDHWMQ	LIM2	16	P55344
MASMRESDTGLWLHN	NELFA	1	Q9H3P2
FRMLAWHVLMGNQVI	FLCN	361	Q8NFG4
VSHRMEMWLLILVAY	LIPM	11	Q5VYY2
SRLQSDWMLMLYFAH	GPR158	636	Q5T848
VMELAEKFWCDHMSL	DST	6156	Q03001
IAMVHYLMVLSANWA	GPM6A	226	P51674
LIDGTNITMEDEHMW	KATNIP	1271	O60303
NITMEDEHMWLIPFS	KATNIP	1276	O60303
TLTMWVMLQTVSDHT	ATP1B2	56	P14415
LLGMETMAWQEIRHA	C2	356	P06681
DMLKMTALHWATEHN	GABPB1	101	Q06547
DAQNITVLAMWMIEH	HERC1	2781	Q15751
VKMCAHMSIVVEFWL	BPIFA3	136	Q9BQP9
LATHFEHLKWNDMME	DDX60L	226	Q5H9U9
TAQETWMALRTIMEH	CPA5	416	Q8WXQ8
WMALRTIMEHTLNHP	CPA5	421	Q8WXQ8
GFQSLRMHMWVEDVL	PCYOX1	146	Q9UHG3
MHWLTELEILAMVFA	PDE1A	241	P54750
QTDLFDSHMLWFLMH	DCAF8	536	Q5TAQ9
QAVHTVMGIWMVSFI	GPR153	126	Q6NV75
DSIFHNNWREMMPLL	DNAJC16	526	Q9Y2G8
MMLVFSASFVVHWLV	KCNJ13	56	O60928
NFMHMLWSSVLQIVL	ABCC2	436	Q92887
QQSDMTMVGSHIDLW	KIAA1549L	491	Q6ZVL6
MMDDSCVLWNIHSVQ	GREB1L	1616	Q9C091
SESHWRTLLQDMLTM	NBAS	1091	A2RRP1
QTVIWMGDRLMSLEH	ERVK-7	1291	P63135
RSQWEMEKHNLESTM	DZIP3	831	Q86Y13
DTTDLSHSRMLHWMV	PTPRO	656	Q16827
VMSWLGASVNSLIHM	OR2AE1	146	Q8NHA4
TMARALEQGHTVAMW	PLIN1	236	O60240
MLHVAWVGDSQVMLV	PPM1E	341	Q8WY54
QELWSIAEAMNMFHA	FADS2B	151	A8MWK0
VYWQELLDLHMEMGL	PDP2	211	Q9P2J9
LRASFWTNMEKLMDH	COG5	326	Q9UP83
QHAKMIFMELNDAWS	GAK	1286	O14976
LQLQMDIFHWQIMDG	HYI	181	Q5T013
KHFIFVMMDILLDWS	GDE1	246	Q9NZC3
MLSSLAVEKLSHWLM	HEATR5B	1176	Q9P2D3
MPFAWTAIHLMNIVS	DOCK7	396	Q96N67
EAEWESINVLLMMHG	CEP70	26	Q8NHQ1
EDMVLWSGLHDAMFT	C16orf96	216	A6NNT2
RMMITSQDVLHSWAV	MT-CO2	151	P00403
ALDSTWSMMEFQHEP	DNAH17	1416	Q9UFH2
QTVIWMGDRLMSLEH	ERVK-25	531	P61570
QTVIWMGDRLMSLEH	ERVK-6	531	Q69384
ELMDHGIVSWDMVSI	ELMO2	156	Q96JJ3
EFSWHNITVLAMEMN	CDH20	456	Q9HBT6
ITEVWDNVAEMHMAL	CCDC188	261	H7C350
THTWLLAANSEVLMM	GPR148	296	Q8TDV2
NIISQMMHVAEYLEW	DGKB	176	Q9Y6T7
TSMTLQWHLYEMARN	CYP11A1	331	P05108
VTLLHIDWLSMVYML	FLVCR1	141	Q9Y5Y0
FHEMQELWTKGMLNA	DNAJC13	991	O75165
DWLCVDFGSMVIHLM	MALSU1	166	Q96EH3
ESFIMESANGWHDIM	HCAR1	166	Q9BXC0
QTVIWMGDRLMSLEH	HERVK_113	531	Q902F9
AHEHIFGMVLMNDWS	FAH	221	P16930
DMEWTSSSKINALMH	HLTF	826	Q14527
EQISKDLAWLTSHMM	FAM135B	301	Q49AJ0
TSHMMTLWTQFLDTV	FAM135B	311	Q49AJ0
VWNEMHSSSAVRMAV	HDAC5	791	Q9UQL6
WLVHIMSDIANMLAL	GPR139	261	Q6DWJ6
IIFSDHGMTDIFWMD	ENPP6	236	Q6UWR7
FMAMLEFLWTLRHSE	GRIK4	821	Q16099
QLSLTMMAQWTHFAR	CES3	491	Q6UWW8
WFEHVSMLVIMLNCV	CACNA1H	101	O95180
GQTHLALMNFSWAMD	CDC27	751	P30260
VDDMFIMISAWHKTN	PTCHD3	456	Q3KNS1
QASWIHRMIMALVSD	PLA2G4A	461	P47712
DMLKMTALHWATERH	GABPB2	101	Q8TAK5
TFRLHWSNMLEKMAD	FER1L6	591	Q2WGJ9
MTVLCSIDWFMVTVH	PLAC1	26	Q9HBJ0
SIDWFMVTVHPFMLN	PLAC1	31	Q9HBJ0
EPLNHSYQAIIMLWM	TAS2R38	86	P59533
VCHLLVANMDESMWA	TAS2R50	141	P59544
VLMDNSLWEAIMGHN	USH2A	5156	O75445
HWLMSNSSELMITHA	PSAPL1	306	Q6NUJ1
RAAMVISWHLASDMD	SMCHD1	1736	A6NHR9
DEAWMILKQVHDTNM	SV2B	311	Q7L1I2
ELQDWMTDAIHMLDS	SYNE1	3291	Q8NF91
WTHEQGSVMMFEHLI	SAMHD1	231	Q9Y3Z3
IAESWMNFSIFLQEM	RETREG1	171	Q9H6L5
VIWDHLSTMYDMQAL	MRGBP	76	Q9NV56
MESGHLLWALLFMQS	HEPH	1	Q9BQS7
VAWYMLAMGQDVDLH	HEPH	986	Q9BQS7
ILWMDHMTSHPVLSQ	SNX33	311	Q8WV41
VLATFVHMLVQWMAD	SHPK	326	Q9UHJ6
KWQGSLEAVMSHLMH	SIAH2	176	O43255
TPLQNSLMELWSLMH	SRCAP	776	Q6ZRS2
SMAVWQHGVILDIME	MROH2B	1251	Q7Z745
HTDEMLWQVLERTFM	ABCC12	1221	Q96J65
SNHMMLNINLWSTLL	SLC35B1	201	P78383
TFDLQPMEWMAAATH	STK36	816	Q9NRP7
WHMDLIQSAVLYSVM	SSR3	51	Q9UNL2
HSSFVTAWMLFPAML	APEH	511	P13798
TDEMFWNHVSMCILN	NT5E	376	P21589
PQLMAWALHFLMDAQ	ACD	436	Q96AP0
MDLHGLFITDMDWDT	BCO1	511	Q9HAY6
NPWTMAIMNVLAELH	CNOT1	1256	A5YKK6
SMFDSLANHTISRWM	SLC7A14	156	Q8TBB6
AGLWASSSHMDQIMF	RAPGEF2	1286	Q9Y4G8
LSMGELLMHSTVSWL	TIAM2	1321	Q8IVF5
SQEMLDFMRELHGAW	NXNL2	76	Q5VZ03
MSLLFIASVFMLHIW	SEC61B	76	P60468
EQDLHRKMHSWMLQT	SLITRK5	11	O94991
WHHDMVMDLAFSVTG	WDR75	246	Q8IWA0
MTGSMALIVLDWVHN	SLC38A2	486	Q96QD8
LLMMFAVHCTWVTSN	STT3B	546	Q8TCJ2
HLIMVWINAFVMLTT	TMEM39A	321	Q9NV64
DEQFTHMLMQWGQFL	PXDN	811	Q92626
WTEGMLQMAFHILAL	UBR1	906	Q8IWV7
LNLLIAMMGDTHWRV	TRPV6	611	Q9H1D0
QHLMWDDIAILARYM	NF1	2071	P21359
KVSAEVMWHLFAQDM	UNC13B	1001	O14795
GHWDFADMMVIRSLS	RFPL2	26	O75678
VGHLETLHMAMSWQD	SIGLEC1	196	Q9BZZ2
TLHMAMSWQDHGRIL	SIGLEC1	201	Q9BZZ2
QKLFQDMLHSIDWMD	SPTB	531	P11277
SNMEFMWQFISEHLD	UBQLNL	186	Q8IYU4
MWQFISEHLDTQQLM	UBQLNL	191	Q8IYU4
LNSVFHFMWVAVLLM	ZDHHC17	536	Q8IUH5
MSLHVDKEQWMFSIC	ZNF827	916	Q17R98
HAQLSEVLWTMVMNS	ATP6V0A4	751	Q9HBG4
FMQHSETFWKDSDML	TTC38	236	Q5R3I4
LESMPHTHIQWFSIM	TM9SF2	291	Q99805
SLRWLEEAEHFAMMV	TTC7A	461	Q9ULT0
ILHSMDRDGTMTIDW	SLC25A23	121	Q9BV35
SEELIYMHWMNTVVN	PLBD2	126	Q8NHP8
LNHMSVPQAMEWLIE	UBAC1	216	Q9BSL1
MASTWAIQAHMDQDE	ZSCAN12	1	O43309
VLASLHVMMTLTNWY	SERINC2	396	Q96SA4
WTSADMMELYEVQLH	SERPINB10	276	P48595
VMARFLWQHGEESMA	TRPM7	636	Q96QT4
MGAEVAFNWIIVHME	USP13	681	Q92995
MTFKERVWNHIMHLE	UGT1A7	201	Q9HAW7
LNLFIAMMGDTHWRV	TRPV5	571	Q9NQA5
HDSELMAFMTRKLWD	UBXN11	71	Q5T124
LAHAQLSDVLWAMLM	ATP6V0A2	761	Q9Y487
WVDVMDQTLNAVGHM	NALCN	556	Q8IZF0
WSISLNMTDEHGNMV	MXRA5	316	Q9NR99
MMWSIHVAKIQSDRE	NEB	3546	P20929