Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

SLC39A5 SLC16A12 SLC38A8 SLC3A1

3.83e-04293244GO:0008514
GeneOntologyMolecularFunctionmodified amino acid transmembrane transporter activity

SLC16A12 SLC3A1

7.15e-0433242GO:0072349
GeneOntologyMolecularFunctioncarboxylic acid transmembrane transporter activity

SLC16A12 SLC38A8 SLC3A1

1.89e-03207243GO:0046943
GeneOntologyMolecularFunctionorganic acid transmembrane transporter activity

SLC16A12 SLC38A8 SLC3A1

1.92e-03208243GO:0005342
GeneOntologyMolecularFunctionL-amino acid transmembrane transporter activity

SLC38A8 SLC3A1

3.27e-0371242GO:0015179
GeneOntologyMolecularFunctioncollagen binding

ITGA10 C6orf15

4.23e-0381242GO:0005518
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

SLC38A8 SLC3A1

7.01e-03105242GO:0015171
GeneOntologyBiologicalProcessresponse to zinc ion starvation

SLC39A5 SP7

4.65e-059242GO:0120127
GeneOntologyBiologicalProcesscellular response to zinc ion starvation

SLC39A5 SP7

4.65e-059242GO:0034224
GeneOntologyBiologicalProcessaggrephagy

ATG4D SQSTM1

1.96e-0418242GO:0035973
MousePhenofailure of neuromuscular synapse postsynaptic differentiation

UTP14C UTP14A

2.08e-056172MP:0001055
MousePhenoabnormal skeleton development

ITGA10 GALC GALNS SQSTM1 SP7

1.47e-04447175MP:0002113
DomainSSU_processome_Utp14

UTP14C UTP14A

1.58e-062242IPR006709
DomainUtp14

UTP14C UTP14A

1.58e-062242PF04615
Domain-

GALC SLC3A1

9.18e-04352423.20.20.80
DomainGlyco_hydro_catalytic_dom

GALC SLC3A1

1.08e-0338242IPR013781
DomainGlycoside_hydrolase_SF

GALC SLC3A1

2.10e-0353242IPR017853
Pubmed

Cryptorchidism rescues spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mice.

UTP14C UTP14A

4.96e-07225214500567
Pubmed

Testosterone inhibits spermatogonial differentiation in juvenile spermatogonial depletion mice.

UTP14C UTP14A

4.96e-07225211415997
Pubmed

Stimulation of spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mutant mice by gonadotropin-releasing hormone antagonist treatment.

UTP14C UTP14A

4.96e-07225210499552
Pubmed

Testosterone suppresses spermatogenesis in juvenile spermatogonial depletion (jsd ) mice.

UTP14C UTP14A

4.96e-07225211466222
Pubmed

Restoration of spermatogenesis and fertility in azoospermic mutant mice by suppression and reelevation of testosterone followed by intracytoplasmic sperm injection.

UTP14C UTP14A

4.96e-07225211751268
Pubmed

Cessation of spermatogenesis in juvenile spermatogonial depletion (jsd/jsd) mice.

UTP14C UTP14A

4.96e-0722529354954
Pubmed

shRNA off-target effects in vivo: impaired endogenous siRNA expression and spermatogenic defects.

UTP14C UTP14A

4.96e-07225225790000
Pubmed

Defect in germ cells, not in supporting cells, is the cause of male infertility in the jsd mutant mouse: proliferation of spermatogonial stem cells without differentiation.

UTP14C UTP14A

4.96e-07225211168646
Pubmed

Loss of sperm in juvenile spermatogonial depletion (jsd) mutant mice is ascribed to a defect of intratubular environment to support germ cell differentiation.

UTP14C UTP14A

4.96e-0722521346141
Pubmed

Androgen suppression-induced stimulation of spermatogonial differentiation in juvenile spermatogonial depletion mice acts by elevating the testicular temperature.

UTP14C UTP14A

4.96e-07225221733828
Pubmed

Isolation of a novel cDNA that encodes a protein localized to the pre-acrosome region of spermatids.

UTP14C UTP14A

1.49e-0632528529672
Pubmed

Juvenile spermatogonial depletion (jsd): a genetic defect of germ cell proliferation of male mice.

UTP14C UTP14A

1.49e-0632523401545
Pubmed

Arrest of spermatogonial differentiation in jsd/jsd, Sl17H/Sl17H, and cryptorchid mice.

UTP14C UTP14A

1.49e-06325210456866
Pubmed

Gene expression alterations by conditional knockout of androgen receptor in adult sertoli cells of Utp14b(jsd/jsd) (jsd) mice.

UTP14C UTP14A

1.49e-06325220650881
Pubmed

Genetic factors contributing to defective spermatogonial differentiation in juvenile spermatogonial depletion (Utp14bjsd) mice.

UTP14C UTP14A

1.49e-06325217475932
Pubmed

The mouse juvenile spermatogonial depletion (jsd) phenotype is due to a mutation in the X-derived retrogene, mUtp14b.

UTP14C UTP14A

1.49e-06325215289605
Pubmed

Utp14b: a unique retrogene within a gene that has acquired multiple promoters and a specific function in spermatogenesis.

UTP14C UTP14A

1.49e-06325217291484
Pubmed

Spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mice with androgen receptor or follicle-stimulating hormone mutations.

UTP14C UTP14A

1.49e-06325216627582
Pubmed

An X-to-autosome retrogene is required for spermatogenesis in mice.

UTP14C UTP14A

1.49e-06325215258580
Pubmed

Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14A in ribosome biogenesis.

UTP14C UTP14A

1.49e-06325230910870
Pubmed

Androgen receptor in Sertoli cells is not required for testosterone-induced suppression of spermatogenesis, but contributes to Sertoli cell organization in Utp14b jsd mice.

UTP14C UTP14A

1.49e-06325219136388
Pubmed

Developmental stage- and spermatogenic cycle-specific expression of transcription factor GATA-1 in mouse Sertoli cells.

UTP14C UTP14A

2.97e-0642527924983
Pubmed

Homeostatic regulation of germinal stem cell proliferation by the GDNF/FSH pathway.

UTP14C UTP14A

2.97e-06425211900972
Pubmed

UTP14c is a recently acquired retrogene associated with spermatogenesis and fertility in man.

UTP14C UTP14A

2.97e-06425216354793
Pubmed

Mapping of genes for inhibin subunits alpha, beta A, and beta B on human and mouse chromosomes and studies of jsd mice.

UTP14C UTP14A

4.95e-0652522767687
Pubmed

p53-dependent apoptosis in the inhibition of spermatogonial differentiation in juvenile spermatogonial depletion (Utp14bjsd) mice.

UTP14C UTP14A

7.43e-06625218356279
Pubmed

Identification of a novel Sry-related gene and its germ cell-specific expression.

UTP14C UTP14A

7.43e-06625210359848
Pubmed

Tisp40, a spermatid specific bZip transcription factor, functions by binding to the unfolded protein response element via the Rip pathway.

UTP14C UTP14A

7.43e-06625215938716
Pubmed

Expression of human and mouse genes encoding polkappa: testis-specific developmental regulation and AhR-dependent inducible transcription.

UTP14C UTP14A

7.43e-06625211733032
Pubmed

Identification and sequencing the juvenile spermatogonial depletion critical interval on mouse chromosome 1 reveals the presence of eight candidate genes.

UTP14C UTP14A

3.85e-051325211700028
Pubmed

An 'equalized cDNA library' by the reassociation of short double-stranded cDNAs.

UTP14C UTP14A

3.85e-05132522216762
Pubmed

The KMT2D Kabuki syndrome histone methylase controls neural crest cell differentiation and facial morphology.

COL16A1 SP7

4.49e-051425232541010
Pubmed

Mouse models of male infertility.

UTP14C UTP14A

6.70e-051725212360237
Pubmed

MRNIP interacts with sex body chromatin to support meiotic progression, spermatogenesis, and male fertility in mice.

UTP14C UTP14A

1.60e-042625235920200
Pubmed

Spermatogonia-dependent expression of testicular genes in mice.

UTP14C UTP14A

1.99e-042925212051830
Pubmed

A BMP-controlled metabolic/epigenetic signaling cascade directs midfacial morphogenesis.

SQSTM1 SP7

6.68e-045325238466355
GeneFamilySolute carriers

SLC39A5 SLC16A12 SLC38A8 SLC3A1

5.39e-04395184752
ToppCelldroplet-Kidney-nan-18m-Epithelial-Epcam____brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL16A1 SLC39A5 SLC3A1

1.09e-04167253ed7e785dcd25777f64e0c2596ada4f5a5ea17121
ToppCelldroplet-Kidney-nan-18m-Epithelial-brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL16A1 SLC39A5 SLC3A1

1.13e-04169253f00741203efa0b948db7223ee8c19bdd0918258a
ToppCellCOVID-19_Severe-MAIT|COVID-19_Severe / Disease condition and Cell class

GALC LTK SQSTM1

1.29e-041772538eb69041f482b58325e3539f607923f7b1fa5977
ToppCellwk_15-18-Mesenchymal-Chondrocyte-Resting_chondrocyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ITGA10 SLC16A12 SP7

1.29e-04177253b01d7a6a78169962123ddfb0bb588f51d138ad02
ToppCell10x3'2.3-week_12-13-Mesenchymal_osteo-stroma-early_osteoblast|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ITGA10 COL16A1 SP7

1.31e-04178253e32f5ed7a492edfa7073416008b1fcfae6b854ad
ToppCellwk_08-11-Mesenchymal-Chondrocyte-Resting_chondrocyte|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

ITGA10 COL16A1 SP7

1.40e-0418225300a148b1e499bf16325491536d187d4dd6b70c06
ToppCelldroplet-Kidney-nan-21m-Epithelial|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THAP4 SLC39A5 SLC3A1

1.40e-04182253942c18a27b22fb33a5200d5717cad972f3ef0576
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ITGA10 COL16A1 UTP14C

1.40e-04182253a1c0e4090a9e7aa4941a40c817d178de144888b6
ToppCell10x3'2.3-week_17-19-Mesenchymal_osteo-stroma-early_osteoblast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ITGA10 COL16A1 SP7

1.43e-0418325327a57cd8ea924420e182f3d72f5b29b00dea8fa0
ToppCelldroplet-Kidney-nan-21m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC39A5 SLC16A12 SLC3A1

1.45e-0418425345577ff91c3b2b303acd97239dde2463ea7a429c
ToppCelldroplet-Kidney-nan-21m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC39A5 SLC16A12 SLC3A1

1.45e-041842533d7dd193a0826cc7a4e454a29236a16c315e5965
ToppCelldroplet-Kidney-nan-3m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC39A5 SLC16A12 SLC3A1

1.47e-041852530ff4148b4701003d9d594e0da8261176fb13aa59
ToppCelldroplet-Kidney-nan-3m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC39A5 SLC16A12 SLC3A1

1.47e-041852533e3217c99719fd1d2fa94e16be7712a7e5077152
ToppCell10x5'-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like-MAIT|lymph-node_spleen / Manually curated celltypes from each tissue

GALC LTK SQSTM1

1.57e-04189253afe3a4fe7c10eeeb7064129778d940269c9acbef
ToppCellParenchymal-NucSeq-Stromal-Chondrocytic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NUTM1 COL16A1 SP7

1.67e-04193253df4afb4848eb9d7d8d39e5c612919663cbbb2514
ToppCell10x5'v1-week_17-19-Mesenchymal_osteo-stroma-early_osteoblast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ITGA10 COL16A1 SP7

1.67e-041932535e46a9f65e85aca78f825fdef88a95b97eec8743
ToppCellParenchymal-NucSeq-Stromal-Chondrocytic-Chondrocyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NUTM1 COL16A1 SP7

1.67e-04193253ab36d684bde8fe77d11a5188425135328052c58b
ToppCell10x3'2.3-week_12-13-Mesenchymal_osteo-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ITGA10 COL16A1 SP7

1.77e-0419725363b63c6b2f842adb87bc83222ff86796bd9b58f6
ToppCell10x3'2.3-week_12-13-Mesenchymal_osteo|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ITGA10 COL16A1 SP7

1.77e-04197253fb50903b87498b400c8e16e6a561b6d9458e5d97
ToppCell10x5'v1-week_12-13-Mesenchymal_osteo-stroma-early_osteoblast|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ITGA10 COL16A1 SP7

1.77e-041972532ca5ebb708935a90b12b8e98a22ae2d664ed002e
ToppCell10x3'2.3-week_14-16-Mesenchymal_osteo-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ITGA10 COL16A1 SP7

1.82e-041992537b1b3b108d817fb3b50a710c3146b30bcf9c2f6b
ToppCell10x5'v1-week_12-13-Mesenchymal_osteo-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ITGA10 COL16A1 SP7

1.82e-04199253d65ee89d5c7e8ed693d58e6a6de09565840e11c5
ToppCell10x3'2.3-week_14-16-Mesenchymal_osteo|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ITGA10 COL16A1 SP7

1.82e-04199253f2ad641f36c577ff7019e88ad6b73ed7e46d8c74
ToppCell10x5'v1-week_12-13-Mesenchymal_osteo|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ITGA10 COL16A1 SP7

1.82e-04199253bf138cc692df727e087d140c014149ee5da00d9d
ToppCell10x5'v1-week_17-19-Mesenchymal_osteo-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ITGA10 COL16A1 SP7

1.85e-042002533c898e81444b001835c3f1bbc68183078701b135
ToppCell10x5'v1-week_14-16-Mesenchymal_osteo-stroma-early_osteoblast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ITGA10 COL16A1 SP7

1.85e-0420025316a7c398626b6e82b394eb3ef013bda3a788659d
ToppCell10x5'v1-week_14-16-Mesenchymal_osteo|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ITGA10 COL16A1 SP7

1.85e-04200253780d47f8eff630020dfae32218de495a7e9dbad6
ToppCell10x5'v1-week_14-16-Mesenchymal_osteo-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ITGA10 COL16A1 SP7

1.85e-0420025328dd127787a57276253548d1f030814b1af64481
ToppCell10x5'v1-week_17-19-Mesenchymal_osteo|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ITGA10 COL16A1 SP7

1.85e-042002533eca8ffeb41b664fbdbbd70b375c5d953503ab29
Drugabequose

GALNS C6orf15 TGDS

1.54e-0621253CID000160540
DrugTyloxapol [25301-02-4]; Down 200; 4uM; HL60; HT_HG-U133A

ITGA10 SQSTM1 SLC3A1 ERI3 UTP14A

2.24e-061992553074_DN
DrugCID365768

GALC GALNS

1.16e-055252CID000365768
Drugsilipide

GALC GALNS

3.23e-058252CID006450536
DrugAC1L1DSW

SQSTM1 UTP14C UTP14A

6.10e-0570253CID000002493
DrugN-acetyl glucosaminuronic acid

GALNS TGDS

6.33e-0511252CID000073494
Drug3,6-dideoxy-D-ribo-hexose

GALNS C6orf15 TGDS

7.20e-0574253CID000193410
DiseaseNephritis, Tubulointerstitial

SLC16A12 SLC3A1

1.00e-0421212C0041349
DiseaseNephritis, Interstitial

SLC16A12 SLC3A1

1.32e-0424212C0027707
DiseaseSeizures

GALC TSEN15

1.04e-02218212C0036572

Protein segments in the cluster

PeptideGeneStartEntry
LPWTWMGPSWGQHPG

ERI3

31

O43414
GGGAAWWPEGDAKPG

C9orf50

56

Q5SZB4
GAPGLWMGSSWQPGP

COL16A1

891

Q07092
WGGSPLGPWLSSGLK

LTK

831

P29376
LLVGMPGLSGAPSWW

OR51S1

21

Q8NGJ8
PLAVPWEGSSGAMWG

NUTM1

676

Q86Y26
MPGWPWGLLLTAGTL

NTN3

1

O00634
GWGTRPMPHPEGIWG

C6orf15

226

Q6UXA7
GGMREPALAWWPGHV

GALNS

316

P34059
GGQRWMLVGAPWDGP

ITGA10

51

O75578
LIGLPWSFPGWLGKG

GALC

146

P54803
SPPDGGWGWMIVAGC

SLC16A12

41

Q6ZSM3
PEGKWPNWMIGGPDS

SLC3A1

436

Q07837
GGWGPSALADPSGLW

SLC38A8

331

A6NNN8
GHFGWPGWEMGPPGN

SQSTM1

191

Q13501
VWAGMPLGPSGWGDL

SLC39A5

106

Q6ZMH5
WTWAEGMGLGPPELS

ATG4D

166

Q86TL0
MSAACWEEPWGLPGG

TGDS

1

O95455
GWGGGAKRPLGDPAW

ZNF503-AS2

176

A6NEH8
TLPGWGEWGGVGLKP

UTP14C

626

Q5TAP6
TPWWDMHPGGNWLGG

SP7

156

Q8TDD2
APEPLSWGAGKAGGW

ZNF646

1451

O15015
LTLPGWGEWGGVGLK

UTP14A

626

Q9BVJ6
DGGGAPSWAPEDAWM

TSEN15

26

Q8WW01
SWMLGTWLSDPPGAG

THAP4

426

Q8WY91