Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cholesterol-protein transferase activity	SHH DHH IHH	4.41e-07	3	153	3	GO:0140853
GeneOntologyMolecularFunction	patched binding	SHH DHH IHH	2.40e-05	8	153	3	GO:0005113
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	DOCK11 CYTH1 DOCK9 ITSN1 DENND2B PREX2 RIN1 GNA13 PLCE1	7.48e-05	231	153	9	GO:0005085
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	DOCK11 STXBP5 CYTH1 DOCK9 ITSN1 TBC1D7 GPS1 DENND2B PREX2 RIN1 GNA13 DEPDC5 PLCE1	1.48e-04	507	153	13	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	DOCK11 STXBP5 CYTH1 DOCK9 ITSN1 TBC1D7 GPS1 DENND2B PREX2 RIN1 GNA13 DEPDC5 PLCE1	1.48e-04	507	153	13	GO:0030695
GeneOntologyMolecularFunction	small GTPase binding	DOCK11 DOCK9 TBC1D7 RUSC2 RIN1 IPO9 NPC1L1 IPO13 DEPDC5 PLCE1	1.89e-04	321	153	10	GO:0031267
GeneOntologyMolecularFunction	calcium ion binding	DSC2 PCDHGB6 PCLO ITSN1 SHH DUOX2 PLA2G4E ITIH1 PCDHB16 CABYR FAT2 DST MCTP1 DHH IHH UNC13A	2.10e-04	749	153	16	GO:0005509
GeneOntologyMolecularFunction	GTPase binding	DOCK11 DOCK9 TBC1D7 RUSC2 RIN1 IPO9 NPC1L1 IPO13 DEPDC5 PLCE1	4.70e-04	360	153	10	GO:0051020
GeneOntologyMolecularFunction	neuregulin binding	ERBB4 ITGAV	8.57e-04	6	153	2	GO:0038132
GeneOntologyMolecularFunction	netrin receptor activity	UNC5B UNC5C	8.57e-04	6	153	2	GO:0005042
GeneOntologyBiologicalProcess	intein-mediated protein splicing	SHH DHH IHH	4.08e-07	3	154	3	GO:0016539
GeneOntologyBiologicalProcess	protein splicing	SHH DHH IHH	4.08e-07	3	154	3	GO:0030908
GeneOntologyBiologicalProcess	neuron development	MYOT FMR1 MYO7A STXBP5 UNC5B TPRN ITSN1 SHH NPHP4 OGDH SLC1A3 PREX2 SLITRK2 DST PTPRD IFT88 AVIL UNC5C EIF4G2 MTR RP1 MMP2 GRIN3A IHH UNC13A KDM1A	3.05e-05	1463	154	26	GO:0048666
GeneOntologyCellularComponent	cytoplasmic region	FMR1 PCLO DNAH2 RSPH6A DST IFT88 RP1 DNAI7 ODAD3 UNC13A DNAH11	6.75e-05	360	152	11	GO:0099568
Domain	Hedgehog_signalling_dom	SHH DHH IHH	5.08e-07	3	150	3	IPR000320
Domain	HintN	SHH DHH IHH	5.08e-07	3	150	3	SM00306
Domain	HintC	SHH DHH IHH	5.08e-07	3	150	3	SM00305
Domain	Hedgehog	SHH DHH IHH	5.08e-07	3	150	3	IPR001657
Domain	HH_signal	SHH DHH IHH	5.08e-07	3	150	3	PF01085
Domain	Hint	SHH DHH IHH	5.08e-07	3	150	3	PF01079
Domain	Hedgehog_sig/DD-Pept_Zn-bd_dom	SHH DHH IHH	5.08e-07	3	150	3	IPR009045
Domain	Hint_dom	SHH DHH IHH	5.08e-07	3	150	3	IPR001767
Domain	-	SHH DHH IHH	5.08e-07	3	150	3	3.30.1380.10
Domain	Hint_dom_N	SHH DHH IHH	5.08e-07	3	150	3	IPR003587
Domain	Hint_dom_C	SHH DHH IHH	5.08e-07	3	150	3	IPR003586
Domain	Hedgehog/Intein_dom	SHH DHH IHH	2.02e-06	4	150	3	IPR028992
Domain	-	SHH DHH IHH	2.02e-06	4	150	3	2.170.16.10
Domain	ARM-type_fold	HGH1 DOCK11 DOCK9 RANBP6 NBEA BTAF1 SDAD1 RIF1 IPO9 EIF4G2 IPO13 AP4B1	1.93e-05	339	150	12	IPR016024
Domain	INTEIN_N_TER	SHH IHH	6.41e-05	2	150	2	PS50817
Domain	Intein_N	SHH IHH	6.41e-05	2	150	2	IPR006141
Domain	C2	PCLO ITSN1 PLA2G4E MCTP1 CAPN5 UNC13A PLCE1	9.11e-05	131	150	7	PF00168
Domain	C2	PCLO ITSN1 PLA2G4E MCTP1 CAPN5 UNC13A PLCE1	1.21e-04	137	150	7	SM00239
Domain	C2	PCLO ITSN1 PLA2G4E MCTP1 CAPN5 UNC13A PLCE1	1.51e-04	142	150	7	PS50004
Domain	-	PCLO ITSN1 PLA2G4E MCTP1 CAPN5 UNC13A PLCE1	1.95e-04	148	150	7	2.60.40.150
Domain	C2_dom	PCLO ITSN1 PLA2G4E MCTP1 CAPN5 UNC13A PLCE1	3.64e-04	164	150	7	IPR000008
Domain	UPA	UNC5B UNC5C	6.31e-04	5	150	2	PF17217
Domain	UPA	UNC5B UNC5C	6.31e-04	5	150	2	IPR033772
Domain	-	UBE2K RNF25 AKTIP UBE2D1	7.45e-04	51	150	4	3.10.110.10
Domain	UBQ-conjugating_enzyme/RWD	UBE2K RNF25 AKTIP UBE2D1	8.62e-04	53	150	4	IPR016135
Domain	DUF3398	DOCK11 DOCK9	9.41e-04	6	150	2	PF11878
Domain	DOCK_C/D_N	DOCK11 DOCK9	9.41e-04	6	150	2	IPR021816
Domain	Cupin_4	TYW5 KDM8	1.31e-03	7	150	2	PF08007
Domain	ARM-like	HGH1 RANBP6 NBEA BTAF1 RIF1 IPO9 IPO13 AP4B1	1.55e-03	270	150	8	IPR011989
Domain	DHC_N1	DNAH2 DNAH11	1.74e-03	8	150	2	PF08385
Domain	Carboxylesterase_B_AS	CEL BCHE	1.74e-03	8	150	2	IPR019826
Domain	CARBOXYLESTERASE_B_1	CEL BCHE	1.74e-03	8	150	2	PS00122
Domain	Dynein_heavy_dom-1	DNAH2 DNAH11	1.74e-03	8	150	2	IPR013594
Domain	-	HGH1 RANBP6 BTAF1 RIF1 IPO9 IPO13 AP4B1	2.14e-03	222	150	7	1.25.10.10
Domain	ZU5	UNC5B UNC5C	2.22e-03	9	150	2	SM00218
Domain	PH_dom-like	MYO7A DOCK11 CYTH1 DOCK9 ITSN1 NBEA PREX2 PTPN4 DGKK PLCE1	2.36e-03	426	150	10	IPR011993
Domain	ZU5	UNC5B UNC5C	2.76e-03	10	150	2	PS51145
Domain	PTPc	PTPN4 PTPRD PTPRH	2.99e-03	36	150	3	SM00194
Domain	DHR-1_domain	DOCK11 DOCK9	3.36e-03	11	150	2	IPR027007
Domain	DHR_2	DOCK11 DOCK9	3.36e-03	11	150	2	PS51651
Domain	DHR_1	DOCK11 DOCK9	3.36e-03	11	150	2	PS51650
Domain	DHR-2	DOCK11 DOCK9	3.36e-03	11	150	2	PF06920
Domain	DOCK	DOCK11 DOCK9	3.36e-03	11	150	2	IPR026791
Domain	DOCK_C	DOCK11 DOCK9	3.36e-03	11	150	2	IPR010703
Domain	DOCK-C2	DOCK11 DOCK9	3.36e-03	11	150	2	PF14429
Domain	DHR-2	DOCK11 DOCK9	3.36e-03	11	150	2	IPR027357
Domain	UQ_con	UBE2K AKTIP UBE2D1	3.75e-03	39	150	3	PF00179
Domain	TYR_PHOSPHATASE_PTP	PTPN4 PTPRD PTPRH	3.75e-03	39	150	3	PS50055
Domain	ZU5	UNC5B UNC5C	4.01e-03	12	150	2	PF00791
Domain	ZU5_dom	UNC5B UNC5C	4.01e-03	12	150	2	IPR000906
Domain	UBIQUITIN_CONJUGAT_2	UBE2K AKTIP UBE2D1	4.33e-03	41	150	3	PS50127
Domain	PTPase_domain	PTPN4 PTPRD PTPRH	4.33e-03	41	150	3	IPR000242
Domain	Y_phosphatase	PTPN4 PTPRD PTPRH	4.33e-03	41	150	3	PF00102
Domain	UBQ-conjugat_E2	UBE2K AKTIP UBE2D1	4.33e-03	41	150	3	IPR000608
Domain	Ig_I-set	MXRA5 MYOT UNC5B IGDCC3 PTPRD UNC5C	4.37e-03	190	150	6	IPR013098
Domain	I-set	MXRA5 MYOT UNC5B IGDCC3 PTPRD UNC5C	4.37e-03	190	150	6	PF07679
Domain	-	MYO7A DOCK11 CYTH1 DOCK9 ITSN1 PREX2 PTPN4 DGKK PLCE1	4.39e-03	391	150	9	2.30.29.30
Domain	Carboxylesterase_B_CS	CEL BCHE	4.72e-03	13	150	2	IPR019819
Domain	TYR_PHOSPHATASE_1	DUSP12 PTPN4 PTPRD PTPRH	5.10e-03	86	150	4	PS00383
Domain	TYR_PHOSPHATASE_dom	DUSP12 PTPN4 PTPRD PTPRH	5.31e-03	87	150	4	IPR000387
Domain	TYR_PHOSPHATASE_2	DUSP12 PTPN4 PTPRD PTPRH	5.31e-03	87	150	4	PS50056
Domain	Dynein_heavy_chain_D4_dom	DNAH2 DNAH11	5.47e-03	14	150	2	IPR024317
Domain	Dynein_HC_stalk	DNAH2 DNAH11	5.47e-03	14	150	2	IPR024743
Domain	CARBOXYLESTERASE_B_2	CEL BCHE	5.47e-03	14	150	2	PS00941
Domain	Dynein_heavy_dom-2	DNAH2 DNAH11	5.47e-03	14	150	2	IPR013602
Domain	DHC_N2	DNAH2 DNAH11	5.47e-03	14	150	2	PF08393
Domain	IMPORTIN_B_NT	IPO9 IPO13	5.47e-03	14	150	2	PS50166
Domain	ATPase_dyneun-rel_AAA	DNAH2 DNAH11	5.47e-03	14	150	2	IPR011704
Domain	COesterase	CEL BCHE	5.47e-03	14	150	2	PF00135
Domain	MT	DNAH2 DNAH11	5.47e-03	14	150	2	PF12777
Domain	AAA_8	DNAH2 DNAH11	5.47e-03	14	150	2	PF12780
Domain	CarbesteraseB	CEL BCHE	5.47e-03	14	150	2	IPR002018
Domain	AAA_5	DNAH2 DNAH11	5.47e-03	14	150	2	PF07728
Domain	DHC_fam	DNAH2 DNAH11	6.28e-03	15	150	2	IPR026983
Domain	Dynein_heavy	DNAH2 DNAH11	6.28e-03	15	150	2	PF03028
Domain	Pept_M10A_Zn_BS	MMP27 MMP2	6.28e-03	15	150	2	IPR021158
Domain	IBN_N	IPO9 IPO13	6.28e-03	15	150	2	PF03810
Domain	Dynein_heavy_dom	DNAH2 DNAH11	6.28e-03	15	150	2	IPR004273
Domain	cAMP_dep_PK_reg_su_I/II_a/b	TEX55 CABYR	6.28e-03	15	150	2	IPR003117
Domain	IBN_N	IPO9 IPO13	7.14e-03	16	150	2	SM00913
Pathway	KEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY_HH_LIGAND_SECRETION	SHH DHH IHH	8.84e-06	6	109	3	M47892
Pathway	REACTOME_RELEASE_OF_HH_NP_FROM_THE_SECRETING_CELL	SHH DHH IHH	1.54e-05	7	109	3	MM15187
Pathway	REACTOME_LIGAND_RECEPTOR_INTERACTIONS	SHH DHH IHH	1.54e-05	7	109	3	MM15224
Pathway	PID_HEDGEHOG_2PATHWAY	SHH STIL DHH IHH	2.22e-05	22	109	4	M211
Pathway	REACTOME_RELEASE_OF_HH_NP_FROM_THE_SECRETING_CELL	SHH DHH IHH	2.45e-05	8	109	3	M27444
Pathway	REACTOME_LIGAND_RECEPTOR_INTERACTIONS	SHH DHH IHH	2.45e-05	8	109	3	M27496
Pathway	KEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY_PTCH_CORECEPTOR	SHH DHH IHH	3.65e-05	9	109	3	M47893
Pathway	KEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY	SHH DHH IHH	1.54e-04	14	109	3	M47414
Pathway	REACTOME_ACTIVATION_OF_SMO	SHH DHH IHH	1.54e-04	14	109	3	MM15228
Pathway	WP_HEDGEHOG_SIGNALING_WP47	SHH DHH IHH	2.34e-04	16	109	3	M39675
Pathway	REACTOME_ACTIVATION_OF_SMO	SHH DHH IHH	3.37e-04	18	109	3	M27500
Pubmed	[Hedgehog signaling pathway and its impact on development of cancer therapy].	SHH DHH IHH	8.68e-08	3	155	3	18788453
Pubmed	The hedgehog signaling pathway in the mouse ovary.	SHH DHH IHH	8.68e-08	3	155	3	17392501
Pubmed	Hedgehog-induced survival of B-cell chronic lymphocytic leukemia cells in a stromal cell microenvironment: a potential new therapeutic target.	SHH DHH IHH	8.68e-08	3	155	3	19074837
Pubmed	Evolution of the hedgehog gene family.	SHH DHH IHH	8.68e-08	3	155	3	8849902
Pubmed	The adventures of Sonic Hedgehog in development and repair. I. Hedgehog signaling in gastrointestinal development and disease.	SHH DHH IHH	8.68e-08	3	155	3	18063705
Pubmed	The world according to hedgehog.	SHH DHH IHH	8.68e-08	3	155	3	9009843
Pubmed	Hedgehog signal transduction: from flies to vertebrates.	SHH DHH IHH	8.68e-08	3	155	3	10579908
Pubmed	A new role for Hedgehogs in juxtacrine signaling.	SHH DHH IHH	8.68e-08	3	155	3	24342078
Pubmed	Comparative biological responses to human Sonic, Indian, and Desert hedgehog.	SHH DHH IHH	8.68e-08	3	155	3	11472839
Pubmed	Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina.	SHH DHH IHH	3.46e-07	4	155	3	9053312
Pubmed	Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.	SHH DHH IHH	3.46e-07	4	155	3	7916661
Pubmed	Developmental pathways in breast cancer and breast tumor-initiating cells: therapeutic implications.	SHH DHH IHH	8.63e-07	5	155	3	22123293
Pubmed	Hedgehog signal activation coordinates proliferation and differentiation of fetal liver progenitor cells.	SHH DHH IHH	8.63e-07	5	155	3	19559697
Pubmed	Hedgehog and patched gene expression in adult ocular tissues.	SHH DHH IHH	8.63e-07	5	155	3	9237688
Pubmed	Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein.	SHH DHH IHH	8.63e-07	5	155	3	10050855
Pubmed	All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.	SHH DHH IHH	8.63e-07	5	155	3	20519495
Pubmed	Products, genetic linkage and limb patterning activity of a murine hedgehog gene.	SHH DHH IHH	8.63e-07	5	155	3	7720571
Pubmed	Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis.	SHH DHH IFT88 IHH	8.63e-07	17	155	4	23955340
Pubmed	Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor.	SHH DHH IHH	1.72e-06	6	155	3	20978073
Pubmed	Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo.	SHH DHH IHH	1.72e-06	6	155	3	7589793
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	HGH1 MYO7A DOCK11 DOCK9 GPS1 NBEA AK9 SDAD1 TRAFD1 RP1 DNAI7 KDM1A	2.60e-06	497	155	12	36774506
Pubmed	Chromatin remodeler CHD7 is critical for cochlear morphogenesis and neurosensory patterning.	MYO7A SHH CHD7	3.00e-06	7	155	3	34004180
Pubmed	Disruption of Scube2 Impairs Endochondral Bone Formation.	SHH DHH IHH	3.00e-06	7	155	3	25639508
Pubmed	Characterization of two patched receptors for the vertebrate hedgehog protein family.	SHH DHH IHH	3.00e-06	7	155	3	9811851
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	STXBP5 DOCK9 PCLO ITSN1 NBEA SLC1A3 RUSC2 RIN1 DST MAPK10	3.92e-06	347	155	10	17114649
Pubmed	Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1.	SHH DHH IHH	4.78e-06	8	155	3	10529434
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	UNC5B ITSN1 TBC1D7 NBEA SLC1A3 DST UNC5C PEAK1 AP4B1	5.81e-06	285	155	9	34369648
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	MXRA5 FMR1 MYO7A DNAH2 NBEA CHD7 SLC1A3 GTF3C5 ITPA IPO9 UNC5C ZNF281 DNAH11	6.24e-06	638	155	13	31182584
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	PCDHGB6 PCLO ITSN1 GPS1 DNAH2 DUOX2 MAGI3 CAGE1 OGDH DST MIA2 IFT88 GNA13 SCG3 AVIL DGKK PES1 UNC5C ATP11C UTP14C	7.00e-06	1442	155	20	35575683
Pubmed	Basal cell carcinoma preferentially arises from stem cells within hair follicle and mechanosensory niches.	SHH DHH IHH	7.15e-06	9	155	3	25842978
Pubmed	Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation.	SHH DHH IHH	7.15e-06	9	155	3	20570969
Pubmed	Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4.	SHH DHH IHH	7.15e-06	9	155	3	17881493
Pubmed	Primary cilia deficiency in neural crest cells models anterior segment dysgenesis in mouse.	SHH DHH IFT88 IHH	8.26e-06	29	155	4	31845891
Pubmed	Ectodysplasin and Wnt pathways are required for salivary gland branching morphogenesis.	SHH DHH IHH	1.02e-05	10	155	3	21652647
Pubmed	Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo.	SHH DHH IHH	1.02e-05	10	155	3	11311154
Pubmed	Analysis of Nsdhl-deficient embryos reveals a role for Hedgehog signaling in early placental development.	SHH DHH IHH	1.40e-05	11	155	3	17028112
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	MMP27 RIF1 RESF1 MCTP1 TP53BP1	1.69e-05	71	155	5	33541421
Pubmed	Widespread Differential Expression of Coding Region and 3' UTR Sequences in Neurons and Other Tissues.	UNC5B SHH UNC5C	1.85e-05	12	155	3	26687222
Pubmed	Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte.	SHH DHH IHH	1.85e-05	12	155	3	10981962
Pubmed	Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair.	RIF1 DOT1L TP53BP1	1.85e-05	12	155	3	28700933
Pubmed	Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye.	SHH DHH IHH	1.85e-05	12	155	3	18582859
Pubmed	Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog.	SHH DHH IHH	1.85e-05	12	155	3	7590746
Pubmed	Reproductive, Physiological, and Molecular Outcomes in Female Mice Deficient in Dhh and Ihh.	DHH IHH	1.97e-05	2	155	2	29788357
Pubmed	Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond.	SHH IHH	1.97e-05	2	155	2	28574612
Pubmed	Dual targeting of integrin αvβ3 and matrix metalloproteinase-2 for optical imaging of tumors and chemotherapeutic delivery.	ITGAV MMP2	1.97e-05	2	155	2	24737028
Pubmed	Cholesterol modification of hedgehog signaling proteins in animal development.	SHH IHH	1.97e-05	2	155	2	8824192
Pubmed	Hedgehog signaling in mouse ovary: Indian hedgehog and desert hedgehog from granulosa cells induce target gene expression in developing theca cells.	DHH IHH	1.97e-05	2	155	2	15878962
Pubmed	Hedgehog can drive terminal differentiation of amniote slow skeletal muscle.	SHH IHH	1.97e-05	2	155	2	15238161
Pubmed	53BP1-RIF1: sculpting the DNA repair focus in 3D.	RIF1 TP53BP1	1.97e-05	2	155	2	31792447
Pubmed	Regulation of the DNA damage response and gene expression by the Dot1L histone methyltransferase and the 53Bp1 tumour suppressor.	DOT1L TP53BP1	1.97e-05	2	155	2	21383990
Pubmed	New insight into hedgehog signaling in hematological malignancies.	SHH IHH	1.97e-05	2	155	2	24991722
Pubmed	The Hedgehog signalling pathway mediates drug response of MCF-7 mammosphere cells in breast cancer patients.	SHH IHH	1.97e-05	2	155	2	26201092
Pubmed	Differential requirements for shh in mammary tissue and hair follicle morphogenesis.	SHH IHH	1.97e-05	2	155	2	12217324
Pubmed	Hedgehog signaling regulates expansion of pancreatic epithelial cells.	SHH IHH	1.97e-05	2	155	2	15766752
Pubmed	Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction.	SHH IHH	1.97e-05	2	155	2	29088246
Pubmed	Association of polymorphisms of zinc metalloproteinases with clinical response to stem cell therapy.	ACE MMP2	1.97e-05	2	155	2	20625691
Pubmed	IHH, SHH, and primary cilia mediate epithelial-stromal cross-talk during decidualization in mice.	SHH IHH	1.97e-05	2	155	2	36853961
Pubmed	CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks.	CHD7 TP53BP1	1.97e-05	2	155	2	33188175
Pubmed	Hedgehog-dependent regulation of angiogenesis and myogenesis is impaired in aged mice.	SHH DHH	1.97e-05	2	155	2	24135022
Pubmed	Transmigration of human ovarian adenocarcinoma cells through endothelial extracellular matrix involves alphav integrins and the participation of MMP2.	ITGAV MMP2	1.97e-05	2	155	2	15609323
Pubmed	53BP1/RIF1 signaling promotes cell survival after multifractionated radiotherapy.	RIF1 TP53BP1	1.97e-05	2	155	2	31822909
Pubmed	The RIF1-long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress.	RIF1 TP53BP1	1.97e-05	2	155	2	33141022
Pubmed	Opposite expression patterns of Sonic hedgehog and Indian hedgehog are associated with aberrant methylation status of their promoters in colorectal cancers.	SHH IHH	1.97e-05	2	155	2	20854074
Pubmed	Combining hedgehog signaling inhibition with focal irradiation on reduction of pancreatic cancer metastasis.	SHH IHH	1.97e-05	2	155	2	23468532
Pubmed	Bradykinin promotes migration and invasion of hepatocellular carcinoma cells through TRPM7 and MMP2.	TRPM7 MMP2	1.97e-05	2	155	2	27693494
Pubmed	Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase activity in neurons.	FMR1 DGKK	1.97e-05	2	155	2	27233938
Pubmed	RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection.	RIF1 TP53BP1	1.97e-05	2	155	2	23333305
Pubmed	Distinct expression patterns of hedgehog ligands between cultured and primary colorectal cancers are associated with aberrant methylation of their promoters.	SHH IHH	1.97e-05	2	155	2	19856079
Pubmed	Novel neutralizing hedgehog antibody MEDI-5304 exhibits antitumor activity by inhibiting paracrine hedgehog signaling.	SHH IHH	1.97e-05	2	155	2	24344235
Pubmed	53BP1 regulates DSB repair using Rif1 to control 5' end resection.	RIF1 TP53BP1	1.97e-05	2	155	2	23306437
Pubmed	Disruption of matrix metalloproteinase 2 binding to integrin alpha vbeta 3 by an organic molecule inhibits angiogenesis and tumor growth in vivo.	ITGAV MMP2	1.97e-05	2	155	2	11134507
Pubmed	In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cells.	SLC1A3 IFT88	1.97e-05	2	155	2	21112568
Pubmed	Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours.	SHH IHH	1.97e-05	2	155	2	14520411
Pubmed	Astrocyte-Specific Inhibition of the Primary Cilium Suppresses C3 Expression in Reactive Astrocyte.	SLC1A3 IFT88	1.97e-05	2	155	2	38822888
Pubmed	Increased production of sonic hedgehog by ballooned hepatocytes.	SHH IHH	1.97e-05	2	155	2	21547909
Pubmed	Expression patterns of Hedgehog signalling pathway members during mouse palate development.	SHH DHH IHH	2.40e-05	13	155	3	16168717
Pubmed	Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration.	SHH DHH IHH	2.40e-05	13	155	3	32332736
Pubmed	Interaction between hedgehog signalling and PAX6 dosage mediates maintenance and regeneration of the corneal epithelium.	SHH DHH IHH	2.40e-05	13	155	3	22275805
Pubmed	Hedgehog signaling regulates sensory cell formation and auditory function in mice and humans.	SHH DHH IHH	2.40e-05	13	155	3	18632939
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	MXRA5 MYO7A DOCK11 PCLO ITSN1 DNAH2 IGDCC3 MAGI3 NBEA UBE2D1 DST KDM8 MMP2	2.80e-05	736	155	13	29676528
Pubmed	Genetic interaction between Gli3 and Ezh2 during limb pattern formation.	SHH DHH IHH	3.05e-05	14	155	3	29729398
Pubmed	Lineage specification of ovarian theca cells requires multicellular interactions via oocyte and granulosa cells.	SHH DHH IHH	3.80e-05	15	155	3	25917826
Pubmed	Ubc13-Mms2 cooperates with a family of RING E3 proteins in budding yeast membrane protein sorting.	UBE2K AKTIP UBE2D1	3.80e-05	15	155	3	32265276
Pubmed	Pth1r in Neural Crest Cells Regulates Nasal Cartilage Differentiation.	SHH DHH IHH	3.80e-05	15	155	3	38234039
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	FMR1 FAM221A ITSN1 GPS1 MAGI3 RUSC2 KANSL2 IFT88 IPO13 MAPKBP1 MAPK10	4.59e-05	560	155	11	21653829
Pubmed	Loss of the Tg737 protein results in skeletal patterning defects.	SHH IFT88 IHH	4.66e-05	16	155	3	12701101
Pubmed	GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling.	SHH DHH IHH	4.66e-05	16	155	3	26932670
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	SAMD9 FMR1 ITSN1 SDAD1 PRDX6 RIN1 RIF1 DST PREP TP53BP1	5.49e-05	472	155	10	38943005
Pubmed	Overactivation of hedgehog signaling alters development of the ovarian vasculature in mice.	SHH DHH IHH	5.64e-05	17	155	3	22402963
Pubmed	Hedgehog signaling maintains resident hepatic progenitors throughout life.	SHH IHH	5.90e-05	3	155	2	16322088
Pubmed	Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels.	SHH IHH	5.90e-05	3	155	2	21537345
Pubmed	Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation.	SHH IHH	5.90e-05	3	155	2	19109233
Pubmed	Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP.	SHH DHH	5.90e-05	3	155	2	19561611
Pubmed	alpha v beta3-dependent cross-presentation of matrix metalloproteinase-2 by melanoma cells gives rise to a new tumor antigen.	ITGAV MMP2	5.90e-05	3	155	2	15998788
Pubmed	Expression and subcellular distribution of imp13 are regulated in brain development.	IPO9 IPO13	5.90e-05	3	155	2	23605716
Pubmed	The Primary Ciliary Deficits in Cerebellar Bergmann Glia of the Mouse Model of Fragile X Syndrome.	FMR1 SHH	5.90e-05	3	155	2	35438410
Pubmed	Role of the netrin system of repellent factors on synovial fibroblasts in rheumatoid arthritis and osteoarthritis.	UNC5B UNC5C	5.90e-05	3	155	2	19822088
Pubmed	The communal relation of MTHFR, MTR, ACE gene polymorphisms and hyperhomocysteinemia as conceivable risk of coronary artery disease.	ACE MTR	5.90e-05	3	155	2	28514598
Pubmed	Structure of Slitrk2-PTPδ complex reveals mechanisms for splicing-dependent trans-synaptic adhesion.	SLITRK2 PTPRD	5.90e-05	3	155	2	25989451
Pubmed	The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides.	SHH IHH	5.90e-05	3	155	2	11476578
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	MXRA5 MYOT UNC5B IGDCC3 PTPRD UNC5C	2.05e-04	161	95	6	593
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PCLO ITSN1 CAPN5	8.85e-04	36	95	3	823
GeneFamily	Ubiquitin conjugating enzymes E2	UBE2K AKTIP UBE2D1	1.30e-03	41	95	3	102
CoexpressionAtlas	FacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3	DOCK11 PCLO IGDCC3 MAGI3 CHD7 BTAF1 SSB STIL PREX2 PTPN4 RIF1 MIA2 TYW5 SCG3 NMT2 EIF4G2 ATP11C UTP14C	5.81e-08	532	153	18	Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
CoexpressionAtlas	DevelopingGonad_e11.5_ovary + mesonephros_emap-3226_top-relative-expression-ranked_1000	TRPM7 DOCK11 UNC5B ITSN1 WASF3 HEMGN CHD7 THSD7B SLC1A3 PREX2 PRDX6 RIF1 SLITRK2 RESF1 GNA13 NMT2 DEPDC5 MAPK10	2.44e-05	815	153	18	gudmap_developingGonad_e11.5_ovary + mesonephros_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Medial Nasal Eminence_top-relative-expression-ranked_1000_k-means-cluster#5	PCLO RNF25 CHD7 SLC1A3 SCG3 EIF4G2 MAPK10	3.27e-05	124	153	7	Facebase_RNAseq_e10.5_Medial Nasal Eminence_1000_K5
CoexpressionAtlas	dev lower uro neuro_e15.5_BladdPelvicGanglion_Sox10_k-means-cluster#4_top-relative-expression-ranked_1000	STXBP5 PCLO BCHE CHD7 SLITRK2 SCG3 DGKK DDX25 MAPK10 UNC13A	3.49e-05	278	153	10	gudmap_dev lower uro neuro_e15.5_BladdPelvicGanglion_Sox10_k4_1000
CoexpressionAtlas	dev lower uro neuro_e14.5_BladdPelvicGanglion_Sox10_top-relative-expression-ranked_500	PCLO TBC1D7 GPS1 BCHE CHD7 MOXD1 SLITRK2 SCG3 DGKK DDX25 MAPK10 UNC13A	8.56e-05	440	153	12	gudmap_dev lower uro neuro_e14.5_BladdPelvicGanglion_Sox10_500
CoexpressionAtlas	dev lower uro neuro_e14.5_BladdPelvicGanglion_Sox10_k-means-cluster#3_top-relative-expression-ranked_1000	PCLO BCHE CHD7 SLITRK2 SCG3 DGKK UNC5C UNC13A	1.11e-04	202	153	8	gudmap_dev lower uro neuro_e14.5_BladdPelvicGanglion_Sox10_k3_1000
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l30\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPHX2 NAPEPLD IGDCC3 MOXD1 SLITRK2 SCG3 CCDC15 IHH PLCE1	2.03e-08	187	155	9	6f7f293c9cf35261e0e3614e46ec1fb00a701b63
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	BCHE SLC1A3 ABCA8 PREX2 MOXD1 DST PTPRD MMP2 PEAK1	3.48e-08	199	155	9	30d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCell	Control-Epithelial_alveolar-Mes-Like-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FAM221A SHH THSD7B AVIL MTR ZNF470 CAPN5	3.18e-07	127	155	7	556aaf88719c83f307fa50dfac151136ed05c8ad
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SLC1A3 ABCA8 PREX2 DST PTPRD UNC5C MMP2 MAPK10	3.39e-07	189	155	8	203c80030df08ae112f9ae4043709f455d87ce89
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SLC1A3 ABCA8 PREX2 MOXD1 DST PTPRD UNC5C MAPK10	3.98e-07	193	155	8	9f69edc97b868d23998abc98928a2e89a885ef8a
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	BCHE SLC1A3 ABCA8 PREX2 DST PTPRD UNC5C MAPK10	4.14e-07	194	155	8	71d3c7448b1734de54187f902f65649f9283bd4c
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH2 NBEA AK9 IFT88 RP1 DNAI7 MAPK10 DNAH11	4.14e-07	194	155	8	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERBB4 TMEM51 BCHE CHD7 ABCA8 MOXD1 DST SCG3	4.65e-07	197	155	8	1018aac22659c081d227d566afa29b1748c18ade
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERBB4 BCHE CHD7 ABCA8 MOXD1 SLITRK2 DST DHH	4.83e-07	198	155	8	36c97eb71b89bac01cabd6a8b728e5a20e52d2a3
ToppCell	ILEUM-non-inflamed-(8)_Fibroblasts\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	MXRA5 DENND2B ABCA8 DST UNC5C CAPN5 MMP2 MAPK10	5.02e-07	199	155	8	d9d7f36b4b5592b7855448730044c90997b55499
ToppCell	ILEUM-inflamed-(8)_Fibroblasts\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	MXRA5 BCHE DENND2B ABCA8 DST UNC5C MMP2 MAPK10	5.02e-07	199	155	8	3a3e2bb21cd0293622b1a975263e918d9ba24265
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERBB4 MYOT BCHE CHD7 ABCA8 MOXD1 SLITRK2 DST	5.02e-07	199	155	8	1761669ec514fdb4175042f11b9a31fa5687fc2b
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERBB4 NBEA CHD7 ABCA8 MOXD1 DST SCG3 MAPK10	5.21e-07	200	155	8	553e9612874480f4d2a45671462e266cd0a09321
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	BCHE SLC1A3 ABCA8 MOXD1 DST PTPRD UNC5C MMP2	5.21e-07	200	155	8	bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCell	Ionocyte-iono-1\|World / Class top	EPHX2 NAPEPLD CEL ACE MOXD1 SUPT6H PEAK1	2.17e-06	169	155	7	4b68bcb4b5fc3cd2db23cd4edace7444aa2d605c
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Differentiating_glia\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERBB4 BCHE CHD7 ABCA8 MOXD1 DST SCG3	2.44e-06	172	155	7	bc3ed05fdd94d5e1f19285aea867b1453292baec
ToppCell	-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	HEMGN BCHE ABCA8 MOXD1 DGKK UNC5C MMP2	2.54e-06	173	155	7	88be9182fbb1bc83531cd41e59ea57c112a21d54
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYOT BCHE ABCA8 MOXD1 SLITRK2 DST DHH	3.68e-06	183	155	7	547b1fb9f9940cfc8d6e351d96acc0da44def57e
ToppCell	AT1-AT2_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	PCLO WASF3 SHH MAGI3 ABCA8 MAPK10 PLCE1	3.68e-06	183	155	7	6821dca076318115d360ff426eb1218cfe104063
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D122\|Adult / Lineage, Cell type, age group and donor	WASF3 MAGI3 ABCA8 DST RP1 FYB2 PLCE1	3.81e-06	184	155	7	561592edc3083fad41b91811151b442207c65dd9
ToppCell	COPD-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	DNAH2 AK9 RP1 DNAI7 MAPK10 FYB2 DNAH11	4.55e-06	189	155	7	3e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Gad2-Fos_(IEG_state,_GABAergic)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	PIWIL4 STIL PTPRH AVIL NPC1L1	4.60e-06	70	155	5	e1ac00f4a519b6ada89f591e549874bd3eed0ca1
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Gad2-Fos_(IEG_state,_GABAergic)--\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	PIWIL4 STIL PTPRH AVIL NPC1L1	4.60e-06	70	155	5	27e12c0f43a996bcbed285c5ee668bef5a786d80
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Gad2-Fos_(IEG_state,_GABAergic)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	PIWIL4 STIL PTPRH AVIL NPC1L1	4.60e-06	70	155	5	b6815131e87e81c10e65bc398a84dab5a74b32ac
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	BCHE PREX2 MOXD1 UNC5C PEAK1 MAPK10 PLCE1	4.71e-06	190	155	7	7986586b7c82e91c71102cc8c4d7a689ae63ab4d
ToppCell	IPF-Epithelial-Ciliated\|IPF / Disease state, Lineage and Cell class	DNAH2 AK9 RP1 DNAI7 MAPK10 FYB2 DNAH11	5.04e-06	192	155	7	354adc1354bf596fbc60dd45c0169688e6f45165
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	DNAH2 AK9 IFT88 RP1 DNAI7 MAPK10 DNAH11	5.22e-06	193	155	7	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERBB4 BCHE CHD7 ABCA8 MOXD1 SLITRK2 DST	5.22e-06	193	155	7	cdc44bf6f5436eb8a2d4720fe011dcb85ccecf87
ToppCell	21-Trachea-Mesenchymal-Mesenchyme_RSPO2+\|Trachea / Age, Tissue, Lineage and Cell class	FBLL1 ABCA8 MOXD1 DST PTPRD UNC5C MMP2	5.40e-06	194	155	7	8fc98d2c9d94f3bc6292265e20ab71c4f1f37bb3
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SLC1A3 ABCA8 PREX2 MOXD1 PTPRD UNC5C MMP2	5.40e-06	194	155	7	8c37bedb23285735ff3828db3889897fada8c95d
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	ERBB4 NBEA RP1 DNAI7 MAPK10 FYB2 DNAH11	5.58e-06	195	155	7	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	ERBB4 NBEA RP1 DNAI7 MAPK10 FYB2 DNAH11	5.58e-06	195	155	7	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SLC1A3 ABCA8 MOXD1 DST PTPRD UNC5C MMP2	5.77e-06	196	155	7	1450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	MXRA5 SLC1A3 ABCA8 DST PTPRD MMP2 DNAI7	5.97e-06	197	155	7	fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH2 AK9 RP1 DNAI7 MAPK10 FYB2 DNAH11	5.97e-06	197	155	7	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYOT BCHE CHD7 ABCA8 MOXD1 SLITRK2 DST	6.17e-06	198	155	7	5b9a7b9f53a3d9cf8d6e6a7c1c94514b22cf9fa8
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SLC1A3 ABCA8 MOXD1 DST PTPRD UNC5C MMP2	6.17e-06	198	155	7	17dc055e2a289496d9c5cdbf3297bdf906dc6d22
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERBB4 NBEA CHD7 MOXD1 DST SCG3 MAPK10	6.37e-06	199	155	7	86739a6f5e0fa7448389b97b3c4de41f2a7d7ebd
ToppCell	Fibroblasts\|World / lung cells shred on cell class, cell subclass, sample id	MXRA5 CEL BCHE ABCA8 MOXD1 CAPN5 MMP2	6.37e-06	199	155	7	e2b6752fcabd5249a166486ae6796f2c97c1fcaf
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERBB4 BCHE CHD7 ABCA8 MOXD1 SLITRK2 DST	6.37e-06	199	155	7	f1d5808ccb1d5d4e2d34f864e705e2484000e88f
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SLC1A3 ABCA8 MOXD1 DST PTPRD UNC5C MMP2	6.37e-06	199	155	7	a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCLO CHD7 ABCA8 MOXD1 SLITRK2 DST SCG3	6.37e-06	199	155	7	47466253069d4b1b8f13ce3210f434e60753b38a
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	MXRA5 ITSN1 SLC1A3 MOXD1 DST PTPRD MMP2	6.37e-06	199	155	7	e1849505b92820a219c5a2c35492bdd55579fb48
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SLC1A3 ABCA8 PREX2 MOXD1 DST PTPRD MMP2	6.59e-06	200	155	7	9b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DOCK9 CHD7 ACE PREX2 DST RESF1 MCTP1	6.59e-06	200	155	7	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	Control_saline-Mesenchymal_fibroblastic\|Control_saline / Treatment groups by lineage, cell group, cell type	MYO7A BCHE SLC1A3 ABCA8 MOXD1 PTPRD MMP2	6.59e-06	200	155	7	64ae5cf6cb4fc94cf1052abd82648f6b8e6445fe
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ITSN1 SLC1A3 ABCA8 MOXD1 DST PTPRD MMP2	6.59e-06	200	155	7	b79628fd1386aa9a3b0e9fa81def0bc100c3c073
ToppCell	Neuronal-Inhibitory\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ERBB4 DOCK11 THSD7B PREX2 ATP11C GRIN3A PLCE1	6.59e-06	200	155	7	9ff8647e2de0b538e15929dca88ebb20ff7ab043
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ITSN1 SLC1A3 ABCA8 MOXD1 DST PTPRD MMP2	6.59e-06	200	155	7	50ca6550998e461ef26dd670351060bd940765a8
ToppCell	(5)_Fibroblasts\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	MXRA5 BCHE ABCA8 MOXD1 DST CAPN5 MMP2	6.59e-06	200	155	7	22c839f27d3abdf86bfabdfa305f205dd899a9dc
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SLC1A3 ABCA8 PREX2 MOXD1 DST PTPRD MMP2	6.59e-06	200	155	7	44a68bacdb3d5bf563bd35952176995850933a81
ToppCell	LPS_only-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_only / Treatment groups by lineage, cell group, cell type	ITSN1 SLC1A3 ABCA8 MOXD1 DST PTPRD MMP2	6.59e-06	200	155	7	a7ef7022b8efcaedb7319b0b43d8c4e99d788fe2
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts\|Control_saline / Treatment groups by lineage, cell group, cell type	MYO7A BCHE SLC1A3 ABCA8 MOXD1 PTPRD MMP2	6.59e-06	200	155	7	a1fc74c1b27e104895910bc7cdce7ba33d30df7e
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SLC1A3 ABCA8 PREX2 MOXD1 DST PTPRD MMP2	6.59e-06	200	155	7	dc61016c61729f69649cfb21f6264e685ce83dea
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH2 DUOX2 RP1 ODAD3 FYB2 DNAH11	1.74e-05	155	155	6	5f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH2 DUOX2 RP1 ODAD3 FYB2 DNAH11	1.74e-05	155	155	6	0944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Differentiating_glia\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYOT BCHE CHD7 ABCA8 MOXD1 SLITRK2	2.39e-05	164	155	6	57301178e420983c0cb72178e288a3a0449fdda3
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGAV SLITRK2 DST PTPRD UNC5C PLCE1	2.73e-05	168	155	6	e96859dbf51cf8c4def8ee8db132f4d874fb4381
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH2 NBEA AK9 RP1 MAPK10 DNAH11	2.83e-05	169	155	6	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	ileum\|World / shred on tissue and cell subclass	EPHX2 DSC2 ACE DST RESF1 PTPRH	2.92e-05	170	155	6	9f1211bd4287620e19a59f21e6ecdca3e42e0260
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CWH43 DSC2 DST PTPRD PTPRH UTP14C	3.22e-05	173	155	6	e1378201b15ffb98e196ac39fe3ee4b4078953bd
ToppCell	facs-Large_Intestine-Proximal-3m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CWH43 DSC2 DST PTPRD PTPRH UTP14C	3.22e-05	173	155	6	99532bb768ee35fed939a377acb5215d3f8904bd
ToppCell	Control-Epithelial_cells-AT1\|Control / group, cell type (main and fine annotations)	WASF3 MAGI3 DST RP1 FYB2 PLCE1	3.33e-05	174	155	6	548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCell	356C-Fibroblasts-Fibroblast-G\|356C / Donor, Lineage, Cell class and subclass (all cells)	MXRA5 BCHE MOXD1 DST PTPRD MMP2	3.66e-05	177	155	6	8220cc2fc0ee8764a67a3be51d75248be2453040
ToppCell	356C-Fibroblasts-Fibroblast-G-\|356C / Donor, Lineage, Cell class and subclass (all cells)	MXRA5 BCHE MOXD1 DST PTPRD MMP2	3.66e-05	177	155	6	7617270f49cd6b7ba66db72d20560cee985012b2
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYOT CHD7 ABCA8 MOXD1 SLITRK2 DST	4.15e-05	181	155	6	a436e7e4c36403257ea90160a58ca0d6d7c0cdfc
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast\|E18.5-samps / Age Group, Lineage, Cell class and subclass	SLC1A3 PREX2 PTPRD UNC5C MMP2 PEAK1	4.28e-05	182	155	6	ceb37c214662a48efb56ab0d015977c6fab478b0
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BCHE CHD7 ABCA8 MOXD1 DST SCG3	4.28e-05	182	155	6	d6740bca2b974122b8451989365a94a81140afd1
ToppCell	facs-Liver-Hepatocytes-24m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3AP1 DSC2 ITIH1 PTPRD MIA2 OXSM	4.41e-05	183	155	6	d0721c6aa426953a520d40e976b6e65aa7ca65e8
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCLO SLITRK2 PTPRD DGKK PLCE1 DNAH11	4.55e-05	184	155	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 UNC5B THSD7B PREX2 ATP11C GRIN3A	4.55e-05	184	155	6	e2de27cee3ea80f9b7a9a7884ceceeaa67b3214a
ToppCell	3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYOT CHD7 ABCA8 MOXD1 SLITRK2 DST	4.55e-05	184	155	6	226ccac00ac1c3a0ad7283785fd14312320e0ca6
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCLO SLITRK2 PTPRD DGKK PLCE1 DNAH11	4.55e-05	184	155	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCLO SLITRK2 PTPRD DGKK PLCE1 DNAH11	4.55e-05	184	155	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1\|Children_(3_yrs) / Lineage, Cell type, age group and donor	WASF3 MAGI3 DST RP1 FYB2 PLCE1	4.69e-05	185	155	6	1c222f7285d6e3dae0354dc7e853ddc0ea55e63e
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	ERBB4 DOCK9 MAGI3 PTPRD RP1 MAPK10	4.69e-05	185	155	6	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	BCHE CHD7 SLC1A3 PREX2 PLCE1 DNAH11	4.69e-05	185	155	6	2e1766f1a972fecd670daaaf7eb2d3a404f121e7
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	BCHE CHD7 SLC1A3 PREX2 PLCE1 DNAH11	4.69e-05	185	155	6	7aaa8335b40927e3e8fdcede807cd521fc213a0d
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-OPC\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 BCHE CHD7 SLC1A3 PREX2 DNAH11	4.97e-05	187	155	6	daff7ccd3f1924cf2b34d3aca3eccde245aaf371
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 BCHE CHD7 SLC1A3 PREX2 DNAH11	4.97e-05	187	155	6	5b7a1edee602e55d3400dc17dbb6b8aaa26defc0
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1\|Adult / Lineage, Cell type, age group and donor	WASF3 MAGI3 ABCA8 DST PEAK1 PLCE1	4.97e-05	187	155	6	77f78aec946bc6bd85c29aee9ca978ce49f853a3
ToppCell	3'-GW_trimst-2-LargeIntestine-Neuronal\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYOT CHD7 ABCA8 MOXD1 SLITRK2 DST	5.12e-05	188	155	6	ccd2541892112a7a303f766adf9a7afeb754498c
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Artery\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	UNC5B DOCK9 LRRK1 PREX2 MCTP1 DHH	5.28e-05	189	155	6	c45734970036e6d28d5e3fe7c9458fae38a3f624
ToppCell	LPS_only-Endothelial-Endothelial-Artery\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	UNC5B DOCK9 LRRK1 PREX2 MCTP1 DHH	5.28e-05	189	155	6	b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCell	E12.5-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CHD7 MOXD1 SLITRK2 DHH SCG3 MAPK10	5.28e-05	189	155	6	620d30bb6211fff6adab0638d0d994f547167a29
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 THSD7B PREX2 MCTP1 ATP11C GRIN3A	5.43e-05	190	155	6	56cc761e50fddfb5366391518b4d8e16589b6b42
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 THSD7B PREX2 MCTP1 ATP11C GRIN3A	5.43e-05	190	155	6	25d4b591f75c26e404a34c42f1742d580af6598d
ToppCell	Monocytes-Tissue-resident_macrophages\|World / Immune cells in Kidney/Urine in Lupus Nephritis	DSC2 UNC5B TMEM51 SLC1A3 DST MMP2	5.43e-05	190	155	6	07215e8f292cb54c670037aaf28393cddbe5548c
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal\|E16.5-samps / Age Group, Lineage, Cell class and subclass	SLC1A3 PREX2 PTPRD UNC5C MMP2 PEAK1	5.59e-05	191	155	6	3379d145d34f89150f7b06d1340022cfc6b4a6ce
ToppCell	Children_(3_yrs)-Epithelial-club_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ERBB4 MAGI3 NBEA PTPRD RP1 MAPK10	5.59e-05	191	155	6	23776c7302cead3881b39127398f3b3e0d27885e
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	BCHE SLC1A3 PREX2 MOXD1 UNC5C MAPK10	5.59e-05	191	155	6	fa380a8752de158974b2ae5e741573439719cc0d
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ACE PREX2 MOXD1 DST MCTP1 DHH	5.59e-05	191	155	6	b270c3dd5952f56b9bdceabe13e298fe6757563b
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 SLC1A3 PREX2 PRDX6 SLITRK2 SCG3	5.76e-05	192	155	6	d2161842a38146261847fc9061ba9322e0f087e0
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 SLC1A3 PREX2 SLITRK2 SCG3 UTP14C	5.76e-05	192	155	6	261211a86e6f63b09c2ddce1d2d9257d311f1770
ToppCell	PND14-Mesenchymal-Mesenchymal_structural\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC1A3 PREX2 PTPRD UNC5C MMP2 PEAK1	5.76e-05	192	155	6	25492568f9cbe097b7bb1db50d8b817c80ea87d7
ToppCell	COVID-19-kidney-CNT\|kidney / Disease (COVID-19 only), tissue and cell type	ERBB4 MXRA5 CWH43 DENND2B MAPK10 FYB2	5.76e-05	192	155	6	d32ae226d95b4b6adb99d14b602be09b661d4cd9
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC1A3 ABCA8 MOXD1 PTPRD UNC5C MMP2	5.76e-05	192	155	6	dcd924d6eb67d33ee9f5d3e8ab6e1d4283d6b708
ToppCell	(7)_Epithelial_cells-(7)_Epithelial-H_(AT1)\|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	MXRA5 CEL DSC2 CABYR FAT2 DST	5.76e-05	192	155	6	7a6dd2ae217b8f8e460d47ad128904408299458c
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC1A3 PREX2 PTPRD UNC5C MMP2 PEAK1	5.76e-05	192	155	6	de9c1536d5aee86f9c62acbc54ca8fa581c00f17
ToppCell	wk_15-18-Epithelial-PNS-FGFBP2+_Neural_progenitor\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	PCLO NBEA PREP SCG3 DDX25 CHAC1	5.76e-05	192	155	6	ab54d4bfc61ef7e3d765afe6e4a6d7011a301ecd
Disease	primary bacterial infectious disease (implicated_via_orthology)	SHH DUOX2 DHH IHH	8.14e-08	9	151	4	DOID:0050338 (implicated_via_orthology)
Disease	wellbeing measurement, alcohol consumption measurement	STXBP5 MMP27 SHH PREX2 DST HSD17B12 UNC13A	1.08e-07	74	151	7	EFO_0007869, EFO_0007878
Disease	chronic hepatitis C virus infection	CWH43 AK9 ITPA DEPDC5	2.40e-05	33	151	4	EFO_0004220
Disease	coronary artery disease	ERBB4 CEL TRPM7 DOCK9 TBC1D7 WASF3 HEMGN DUOX2 MAGI3 RSPH6A DENND2B ABCA8 UNC5C SF3A3 HSD17B12 RP1 UNC13A PLCE1	4.18e-05	1194	151	18	EFO_0001645
Disease	netrin receptor UNC5B measurement	UNC5B UNC5C	1.55e-04	4	151	2	EFO_0802792
Disease	primary progressive multiple sclerosis (is_marker_for)	SHH BCHE	3.85e-04	6	151	2	DOID:0050784 (is_marker_for)
Disease	Cerebral Hemorrhage	ACE ITGAV MMP2	3.92e-04	28	151	3	C2937358
Disease	Dengue Hemorrhagic Fever	RP1 PLCE1	5.37e-04	7	151	2	EFO_0004227
Disease	Nephronophthisis, familial juvenile	NPHP4 MAPKBP1	5.37e-04	7	151	2	C1855681
Disease	autism spectrum disorder (is_marker_for)	SHH IHH	5.37e-04	7	151	2	DOID:0060041 (is_marker_for)
Disease	serum alanine aminotransferase measurement	PIK3AP1 TRPM7 PCLO DNAH2 SHH PIWIL4 DEFA6 TRAFD1 RESF1 HSD17B12 RP1 MAPK10 PLCE1	5.49e-04	869	151	13	EFO_0004735
Disease	Schizophrenia	EPHX2 ERBB4 DYM FMR1 GPS1 ACE SLC1A3 ITIH1 PRDX6 PNPO UNC5C MTR GRIN3A	6.37e-04	883	151	13	C0036341
Disease	tumor necrosis factor receptor superfamily member 19L measurement	BCHE RELT	7.14e-04	8	151	2	EFO_0008309
Disease	Bipolar Disorder	ERBB4 DOCK9 PCLO BCHE ACE SLC1A3 ITIH1 MTR GRIN3A	8.16e-04	477	151	9	C0005586
Disease	lung carcinoma	EPHX2 MAGI3 AK9 OGDH SDAD1 RIF1 RP1 TP53BP1 DNAH11	8.78e-04	482	151	9	EFO_0001071
Disease	Todd Paralysis	TRPM7 BCHE	9.15e-04	9	151	2	C0234544
Disease	Paralysed	TRPM7 BCHE	9.15e-04	9	151	2	C0522224
Disease	bile salt-activated lipase measurement	CEL GTF3C5	9.15e-04	9	151	2	EFO_0801425
Disease	abdominal aortic aneurysm (implicated_via_orthology)	ACE MMP2	9.15e-04	9	151	2	DOID:7693 (implicated_via_orthology)
Disease	personality trait	ERBB4 PTPRD PLCE1	1.05e-03	39	151	3	EFO_0004365
Disease	axin-2 measurement	BCHE ITIH1	1.14e-03	10	151	2	EFO_0801400
Disease	Parkinson Disease, Secondary Vascular	SHH BCHE	1.66e-03	12	151	2	C0751414
Disease	Atherosclerotic Parkinsonism	SHH BCHE	1.66e-03	12	151	2	C0751415
Disease	Secondary Parkinson Disease	SHH BCHE	1.66e-03	12	151	2	C0030569
Disease	progression free survival, urinary bladder cancer	ERBB4 SHH	1.66e-03	12	151	2	EFO_0004920, MONDO_0001187
Disease	Hypermetropia	GINM1 CHD7 HSD17B12 ZNF281	1.97e-03	103	151	4	HP_0000540
Disease	myocardial infarction	CEL DOCK9 MAGI3 RSPH6A DENND2B IPO9 UNC5C	2.24e-03	350	151	7	EFO_0000612
Disease	Kartagener syndrome (implicated_via_orthology)	ODAD3 DNAH11	2.27e-03	14	151	2	DOID:0050144 (implicated_via_orthology)
Disease	unipolar depression, anxiety	CYTH1 PTPRD	2.27e-03	14	151	2	EFO_0003761, EFO_0005230
Disease	anemia (is_implicated_in)	ACE ITPA	2.27e-03	14	151	2	DOID:2355 (is_implicated_in)
Disease	aspartate aminotransferase measurement	PIK3AP1 CEL TRPM7 MYO7A DNAH2 THSD7B ITIH1 DEFA6 IPO9 TRAFD1 PTPRD PLCE1	2.44e-03	904	151	12	EFO_0004736
Disease	schizophrenia (biomarker_via_orthology)	ERBB4 KDM1A	2.61e-03	15	151	2	DOID:5419 (biomarker_via_orthology)
Disease	glycerate measurement	THSD7B MCTP1	2.61e-03	15	151	2	EFO_0021029
Disease	diabetic retinopathy (is_marker_for)	ACE MMP2 KDM1A	2.69e-03	54	151	3	DOID:8947 (is_marker_for)
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	ACE IFT88	2.98e-03	16	151	2	DOID:0110861 (implicated_via_orthology)
Disease	ocular hypertension (biomarker_via_orthology)	SHH MMP2	3.36e-03	17	151	2	DOID:9282 (biomarker_via_orthology)
Disease	hypertension (is_implicated_in)	EPHX2 ACE MTR MMP2	3.52e-03	121	151	4	DOID:10763 (is_implicated_in)
Disease	serum IgG measurement	DUSP12 UNC13A	3.77e-03	18	151	2	EFO_0004565
Disease	laryngeal squamous cell carcinoma (is_marker_for)	ERBB4 MMP2	4.20e-03	19	151	2	DOID:2876 (is_marker_for)
Disease	cytomegalovirus virus reactivation, response to allogeneic hematopoietic stem cell transplant	PCLO DEFA6	4.20e-03	19	151	2	EFO_0007044, EFO_0020106
Disease	renovascular hypertension (biomarker_via_orthology)	ACE EIF4G2	4.20e-03	19	151	2	DOID:1591 (biomarker_via_orthology)
Disease	Fetal Growth Retardation	SAMD9 MMP2	4.65e-03	20	151	2	C0015934
Disease	urate measurement, bone density	ERBB4 MAGI3 OGDH ABCA8 PTPRD EIF4G2 HSD17B12 PEAK1 DNAH11	4.72e-03	619	151	9	EFO_0003923, EFO_0004531
Disease	low density lipoprotein cholesterol measurement, physical activity	OGDH RP1 DNAH11	4.75e-03	66	151	3	EFO_0003940, EFO_0004611
Disease	myocardial infarction (implicated_via_orthology)	SHH ACE MMP2	4.75e-03	66	151	3	DOID:5844 (implicated_via_orthology)
Disease	energy intake	TRAFD1 PTPRD UNC5C FYB2	5.06e-03	134	151	4	EFO_0003939

Protein segments in the cluster

Peptide	Gene	Start	Entry
LQPKIQEYEFTDDPI	TADA3	126	O75528
EYSFQDEQDKPLPVP	UNC13A	156	Q9UPW8
DPYNAIEAIDPEKLN	ERBB4	376	Q15303
DKPKQEYLNPVEENP	ERBB4	1156	Q15303
DPQEILLNEAFVVPY	BCHE	296	P06276
ELPEDVNPAKKENYL	AVIL	771	O75366
AVPSKEIQNYGEIPE	CAGE1	231	Q8TC20
LDALDAQPLLKYFQP	ACE	591	P12821
ASPLNPEAAVLYEKD	AKTIP	191	Q9H8T0
PNAPYVLEDFVENVK	AP4B1	451	Q9Y6B7
PPTLEQFKEQIDIYE	DNAH11	1076	Q96DT5
VNEHYLKDPEFNPNL	DNAH11	3271	Q96DT5
PAYDQAPEVTLQADI	CABYR	271	O75952
QNPQYIFEVKKPEDE	CAPN5	386	O15484
DPEKLNNYEPFSPEV	DOT1L	121	Q8TEK3
IPADPINLYANAADI	CEL	316	P19835
NAYEDIVGDLPKENP	DENND2B	486	P78524
QLPDNEPYIFKVFAE	PIK3AP1	546	Q6ZUJ8
VKSDDYLPSIEQQPQ	CHD7	581	Q9P2D1
VNFDLPVKQGEEPDY	DDX25	411	Q9UHL0
PLPLIIKIEDENDNY	DSC2	226	Q02487
LPEKIDAVYEAPQEE	MMP2	516	P08253
NEPDFQYIPEKAPLD	PTPN4	616	P29074
QYIPEKAPLDSVHQD	PTPN4	621	P29074
PATDPDININSIKDY	PCDHGB6	156	Q9Y5F9
SEPEFDLNYVPLKAQ	OXSM	416	Q9NWU1
PKESENALPIQVDYD	DEPDC5	446	O75140
PADLQAAYENPRDKI	MMP27	326	Q9H306
EIYKIPAAENNPFLV	DGKK	311	Q5KSL6
IRKAADPPELEYQEA	IGDCC3	461	Q8IVU1
PSDVQVVQYQELKPD	MCTP1	971	Q6DN14
PQEPYDVVLQRKENE	MAGI3	846	Q5TCQ9
AEVEAPPPQIYDKQL	MAPK10	366	P53779
PLPEVTDEYKNDVKN	SSB	96	P05455
EPDKDNVRQEPYSLP	NMT2	141	O60551
AKPLLVDVDLQYPQD	ITIH1	476	P19827
IADEDARQNPYPVKA	LRRK1	1681	Q38SD2
NQYLQFKETEIPPKE	DST	311	Q03001
NLYPDGPEKRAENLE	GINM1	311	Q9NU53
QIPELKQDISIPDYC	KDM8	281	Q8N371
PNVDPQVLEATAALY	DUOX2	461	Q9NRD8
ENLKPQEQLTLEPYE	FBLL1	301	A6NHQ2
EPLALDNIHLEKPQY	PCLO	2701	Q9Y6V0
NDNRPVFEADPYKAV	FAT2	2791	Q9NYQ8
EEQAKPYRVVNLEQP	PEAK1	456	Q9H792
PDVNYVVENPSLDLE	GPS1	31	Q13098
PNCFELYIPDNKDQV	CYTH1	321	Q15438
AINKDQPANPTEEYA	MED21	41	Q13503
IEALNAYFEKNPLPT	POU6F1	246	Q14863
LEQLYQDQEVPKPKS	PNPO	191	Q9NVS9
LDKLGEPDYIPSQQD	GNA13	181	Q14344
NVDVYDKRENPLLPE	EIF4G2	181	P78344
ENPKQHIPLEEYAAN	IAH1	96	Q2TAA2
VPKGYILDTDQNPAE	HEMGN	266	Q9BXL5
FPEILDANKQPAEAV	NPHP4	606	O75161
NVPATPDGVEYLKND	GRIN3A	821	Q8TCU5
QKPGQAPELVIYEDS	IGLV3-22	56	A0A075B6J6
YVGPDVNPALALEQK	NPC1L1	1291	Q9UHC9
PLHNVKLPEADDIQY	PREP	616	P48147
EFEQPIYKVQIPENS	PCDHB16	241	Q9NRJ7
QNIPFPKYELPDENE	PLA2G4E	746	Q3MJ16
PDVLPDLKEANFDIN	OGDH	806	Q02218
PPVGYNKDINESDEV	FMR1	51	Q06787
NKEIDASYVDPLGPQ	IFT88	781	Q13099
PLESIKANPVFDYQL	EPHX2	371	P34913
PLYEANGQAVPKEKD	KDM1A	361	O60341
EKLQELEANPPSDVY	KDM1A	506	O60341
QNPEFYDEIKIELPI	DOCK11	706	Q5JSL3
QNPEFYDEIKIELPT	DOCK9	706	Q9BZ29
PLQAEDDPLQAKAYE	DEFA6	21	Q01524
EDVLQDLPPKIIQDY	BTAF1	1506	O14981
VPLPDYAQDLNVIEE	DYM	516	Q7RTS9
LSAAPAEQYLQEKLP	FBXO11	146	Q86XK2
DLVPNYNPDIIFKDE	DHH	76	O43323
KPYQLIAQDNETEKP	SLC1A3	521	P43003
FPANYAEKIPENEVP	ITSN1	796	Q15811
FNVIEFPYKNLPIED	ITGAV	956	P06756
QDAPDQPLKALAYVA	CHAC1	131	Q9BUX1
VLNPNENYIEVEKPK	FAM172A	196	Q8WUF8
ETPPCDLQDKNIIQY	DNAI7	151	Q6TDU7
PEYFLDVPDLDNVIK	HSD17B12	141	Q53GQ0
EVYPEVKDSNQACLP	MAPKBP1	396	O60336
VAQKIDLPEYQGEPD	ITPA	36	Q9BY32
DPDALKDPLYQIDLQ	IPO9	991	Q96P70
YKPEQVLSVPDDLEA	KANSL2	371	Q9H9L4
DKNVVKQAEQYVPRP	CCDC168	5606	Q8NDH2
LAQEKPVGQDIPYAA	FAM221A	176	A4D161
EVPNLYKPDEFEEIQ	DNAH2	2841	Q9P225
KVTEKYPELQNLPQE	DUSP12	186	Q9UNI6
DLPPYAANIVAVSQD	IPO13	561	O94829
PYIQQLEKLAEEIPN	IPO13	616	O94829
LTPNYNPDIIFKDEE	IHH	81	Q14623
PDKLDNFYCDVPQLI	OR4D5	171	Q8NGN0
VQLPEVPANENIKGY	PTPRD	1126	P23468
QYLPPDKQREPDADI	HGH1	271	Q9BTY7
NKVYPVSDDAIKNQP	RP1	1876	P56715
LEKDPYALDVPNTAF	MIA2	1106	Q96PC5
PDDPTNYRDNQKVVI	CWH43	646	Q9H720
YLFQKPEVQPEEQEA	RUSC2	446	Q8N2Y8
KPQEAPEYQETAAQL	RTL3	166	Q8N8U3
EPEPLELAVQNAKAY	RSPH6A	191	Q9H0K4
PQYLIELNGNKPAEE	AK9	261	Q5TCS8
AREKPAQDPLYDVPN	RIN1	26	Q13671
ITENLVYEKPEDPLN	TEX55	516	Q96M34
LTPNYNPDIIFKDEE	SHH	76	Q15465
NFQAKPDDLILATYP	SULT1C3	41	Q6IMI6
EKRNEVAIPPNAYDE	TRAFD1	141	O14545
NPNPSDYVLLEEVVK	PLCE1	2181	Q9P212
PLALFYENSKLDEVP	RIF1	861	Q5UIP0
QDDQPYVVDKLAEPQ	RESF1	1121	Q9HCM1
SDIPGDPNNEYKLAL	SAMD9	1236	Q5K651
KELDPQADNYVPNLL	ODAD3	486	A5D8V7
PIYECELASQAPEKQ	FYB2	241	Q5VWT5
DPLNNINVDKDKPYL	NBEA	266	Q8NFP9
INAYNCEEPTEKLPF	PRDX6	86	P30041
LYAEAAVPQAAEPIA	MTR	1046	Q99707
NVDYPKIIKVQENPA	PIWIL4	516	Q7Z3Z4
LLQAKPQSEPDYLEV	SLITRK2	821	Q9H156
PQSEPDYLEVLEKQT	SLITRK2	826	Q9H156
GLEYQTNEPSEEPIK	SMIM23	76	A6NLE4
PEYLSNFPQEVKDLL	SDAD1	71	Q9NVU7
PQLPKAFEQYLNLED	TBC1D7	171	Q9P0N9
PNDFQEPYAVVVLLE	STXBP5	356	Q5T5C0
LLEYENKSPEDPQVL	PDK3	91	Q15120
YPNLPADVQRDVKIE	RANBP6	86	O60518
YKLPVEDVQPLAQAF	ABCA8	1551	O94911
VLPKDQDILPKYQDQ	CCDC15	486	Q0P6D6
NKPPAAPVINEYADA	CNGB3	116	Q9NQW8
AIECEQPQPDLYKFV	ATP11C	211	Q8NB49
QFPAEPLELAKDYVC	SUPT6H	561	Q7KZ85
QPQLYDEKHSPEVEA	STIL	466	Q15468
EELVDLPKNYPLSEN	UTP14C	16	Q5TAP6
SPQEIDPTKENQLYF	TM9SF4	236	Q92544
YFDLVNQDVPIPNKD	MOXD1	186	Q6UVY6
YPPKLEGQAQAEAKA	PES1	246	O00541
NIYKEGQDVPLKPDA	MRPL54	76	Q6P161
VYDLASLKAAPEPQQ	RNF25	206	Q96BH1
VADIYNQSDKPPPLN	WASF3	121	Q9UPY6
PPQYDEVQEKAPDTR	TMEM51	236	Q9NW97
SLNQDIYEEKLPPAI	ZNF470	106	Q6ECI4
DKNYLNFVSPLPDIV	ZNF281	476	Q9Y2X9
EEEPLVANVPLTYQA	PREX2	1356	Q70Z35
EEEEFLEIPPFNKQY	TP53BP1	1761	Q12888
LQEPQDAYIVKNKPV	UNC5B	51	Q8IZJ1
LKPPAENKAEENRYV	RELT	406	Q969Z4
EPDDPQDAVVANQYK	UBE2K	121	P61086
VDSEEAPQAAKLPYL	TPRN	461	Q4KMQ1
DEENEIIYNPKNLPL	SF3A3	371	Q12874
DPRKNPDAKIYQVLD	GTF3C5	306	Q9Y5Q8
LPVAIINLKEYDPDD	TYW1	106	Q9NV66
PQQKPLTLAYDGDLD	THSD7B	1591	Q9C0I4
QQSAQAPAEKEVPYE	PTPRH	1081	Q9HD43
IEPEEAYIVKNKPVN	UNC5C	66	O95185
PQPQEIIYEEALKAT	WDR87	2781	Q6ZQQ6
ISKEANNYEEDPNKP	SCG3	201	Q8WXD2
RNDYTPDKIIFPQDE	TRPM7	1826	Q96QT4
EVLNIDNPDLAKYPL	TYW5	196	A2RUC4
DDPLVPDIAQIYKSD	UBE2D1	116	P51668
DVYKIHLNQTDPPDI	MXRA5	341	Q9NR99
VDKINAAIYKPPSQD	MYO7A	411	Q13402
KYVVALQDNPNPAGE	MYO7A	1606	Q13402
NEHYLEPPVKLNEAL	NAPEPLD	351	Q6IQ20
DVNDQDAIQEKFYPP	MYOT	236	Q9UBF9