Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioninositol 1,4,5-trisphosphate-gated calcium channel activity

ITPR2 ITPR3

5.68e-063282GO:0005220
GeneOntologyMolecularFunctioninositol 1,4,5 trisphosphate binding

ITPR2 ITPR3

1.71e-0414282GO:0070679
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

ITPR2 ITPR3

2.86e-0418282GO:0015278
GeneOntologyMolecularFunctionligand-gated calcium channel activity

ITPR2 ITPR3

8.60e-0431282GO:0099604
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

ITPR2 ITPR3

9.75e-0433282GO:0005217
GeneOntologyMolecularFunctioncyclin binding

RBM4 INSM1

1.10e-0335282GO:0030332
GeneOntologyCellularComponentplatelet dense tubular network membrane

ITPR2 ITPR3

6.65e-059292GO:0031095
GeneOntologyCellularComponentplatelet dense tubular network

ITPR2 ITPR3

1.01e-0411292GO:0031094
MousePhenoimpaired glucose tolerance

PCSK1 EPRS1 KAT2B HERC1 CSHL1 RBM4B RBM4

1.51e-05480257MP:0005293
MousePhenosmall pancreatic islets

RBM4B RBM4 INSM1

7.29e-0546253MP:0009172
MousePhenoabsent somatotrophs

CSHL1 INSM1

1.10e-049252MP:0008330
MousePhenoabnormal enteroendocrine cell morphology

PCSK1 INSM1

2.76e-0414252MP:0004141
MousePhenointermingled spleen red and white pulp

PCSK1 LAMP2

3.18e-0415252MP:0008475
MousePhenoabnormal pancreatic islet morphology

PCSK1 RBM4B RBM4 INSM1

3.34e-04190254MP:0005215
MousePhenoabnormal endocrine pancreas morphology

PCSK1 RBM4B RBM4 INSM1

3.41e-04191254MP:0009165
MousePhenoabnormal glucose tolerance

PCSK1 EPRS1 KAT2B HERC1 CSHL1 RBM4B RBM4

3.43e-04787257MP:0005291
MousePhenodecreased adrenocorticotropin level

PCSK1 INSM1

4.62e-0418252MP:0005128
MousePhenoabnormal pancreatic islet size

RBM4B RBM4 INSM1

5.18e-0489253MP:0009170
MousePhenoreduced fertility

PCSK1 ARHGAP1 LRPAP1 NEK1 LAMP2 GREB1 CSHL1

5.25e-04844257MP:0001921
MousePhenolethality during fetal growth through weaning, incomplete penetrance

PCSK1 ARHGAP1 LRPAP1 NEK1 LAMP2 CFAP70 INSM1 PRDM1

5.33e-041124258MP:0011112
MousePhenoabnormal endocrine gland morphology

PCSK1 ARHGAP1 LRPAP1 LAMP2 CSHL1 RBM4B RBM4 INSM1

6.00e-041144258MP:0013560
MousePhenodecreased somatotroph cell number

CSHL1 INSM1

6.32e-0421252MP:0008329
DomainInsP3_rcpt-bd

ITPR2 ITPR3

6.98e-063292IPR000493
DomainRIH_assoc

ITPR2 ITPR3

3.48e-056292PF08454
DomainRIH_assoc-dom

ITPR2 ITPR3

3.48e-056292IPR013662
DomainRYDR_ITPR

ITPR2 ITPR3

3.48e-056292PF01365
DomainRIH_dom

ITPR2 ITPR3

3.48e-056292IPR000699
DomainIns145_P3_rcpt

ITPR2 ITPR3

3.48e-056292IPR014821
DomainRyanodine_recept-rel

ITPR2 ITPR3

3.48e-056292IPR015925
DomainIns145_P3_rec

ITPR2 ITPR3

3.48e-056292PF08709
Domain-

ITPR2 ITPR3

3.48e-0562921.25.10.30
DomainTPR_8

CFAP70 GTF3C3 TONSL

7.48e-0553293PF13181
DomainMIR

ITPR2 ITPR3

1.04e-0410292PS50919
DomainMIR

ITPR2 ITPR3

1.04e-0410292PF02815
DomainMIR

ITPR2 ITPR3

1.04e-0410292SM00472
DomainMIR_motif

ITPR2 ITPR3

1.04e-0410292IPR016093
Domainzf-CCHC

RBM4B RBM4

5.77e-0423292PF00098
Domain-

RBM4B RBM4

7.39e-04262924.10.60.10
DomainTPR

CFAP70 GTF3C3 TONSL

1.03e-03129293SM00028
DomainTPR_repeat

CFAP70 GTF3C3 TONSL

1.13e-03133293IPR019734
DomainZF_CCHC

RBM4B RBM4

1.34e-0335292PS50158
DomainTPR-contain_dom

CFAP70 GTF3C3 TONSL

1.59e-03150293IPR013026
DomainTPR

CFAP70 GTF3C3 TONSL

2.09e-03165293PS50005
DomainTPR_REGION

CFAP70 GTF3C3 TONSL

2.09e-03165293PS50293
DomainZnF_C2HC

RBM4B RBM4

3.29e-0355292SM00343
DomainZnf_CCHC

RBM4B RBM4

3.29e-0355292IPR001878
Domain-

CFAP70 GTF3C3 TONSL

3.96e-032072931.25.40.10
DomainTPR-like_helical_dom

CFAP70 GTF3C3 TONSL

5.51e-03233293IPR011990
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY

ITPR2 ITPR3

3.26e-055262M49000
PathwayKEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY

ITPR2 ITPR3

4.88e-056262M47960
PathwaySIG_CHEMOTAXIS

ARHGAP1 ITPR2 ITPR3

7.51e-0545263M5193
PathwayKEGG_MEDICUS_REFERENCE_BCR_PLCG_ITPR_SIGNALING_PATHWAY

ITPR2 ITPR3

1.17e-049262M47852
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR2 ITPR3

1.46e-0410262M47661
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR2 ITPR3

1.78e-0411262M49033
PathwayREACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION

ITPR2 ITPR3

1.78e-0411262M27466
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_SIGMAR1_TO_CA2_APOPTOTIC_PATHWAY

ITPR2 ITPR3

2.52e-0413262M47751
PathwayKEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR2 ITPR3

2.52e-0413262M47656
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR2 ITPR3

2.52e-0413262M47696
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

ITPR2 ITPR3

2.52e-0413262MM14553
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

ITPR2 ITPR3

3.86e-0416262M26945
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR2 ITPR3

5.49e-0419262M47760
PathwayREACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION

ITPR2 ITPR3

5.49e-0419262M27423
PathwayKEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY

ITPR2 ITPR3

5.49e-0419262M47733
PathwayKEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY

ITPR2 ITPR3

6.09e-0420262M47688
PathwayREACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN

PCSK1 CSHL1

6.09e-0420262MM15070
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY

ITPR2 ITPR3

6.72e-0421262M47689
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR2 ITPR3

7.39e-0422262M47690
PathwayKEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR2 ITPR3

7.39e-0422262M47675
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR2 ITPR3

8.08e-0423262M47676
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

ITPR2 ITPR3

9.56e-0425262MM14511
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

ITPR2 ITPR3

1.12e-0327262M12123
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

ITPR2 ITPR3

1.12e-0327262MM15053
PathwayKEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION

MYLK3 ITPR2 ITPR3

1.20e-03115263M9387
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

ITPR2 ITPR3

1.20e-0328262M924
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

ITPR2 ITPR3

1.57e-0332262MM14983
PathwayREACTOME_CARDIAC_CONDUCTION

KAT2B ITPR2 ITPR3

1.71e-03130263M27454
PathwaySIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES

ITPR2 ITPR3

1.98e-0336262M1315
PathwayWP_VITAMIN_DSENSITIVE_CALCIUM_SIGNALING_IN_DEPRESSION

ITPR2 ITPR3

1.98e-0336262M39831
PathwayREACTOME_DAG_AND_IP3_SIGNALING

ITPR2 ITPR3

2.57e-0341262M512
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

ITPR2 ITPR3

2.69e-0342262M791
PathwayREACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT

KAT2B INSM1

2.69e-0342262M17541
PathwayWP_RENINANGIOTENSINALDOSTERONE_SYSTEM_RAAS

ITPR2 ITPR3

2.95e-0344262M39845
PathwaySIG_BCR_SIGNALING_PATHWAY

ITPR2 ITPR3

3.22e-0346262M8626
PathwayKEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY

ITPR2 ITPR3

3.79e-0350262M47951
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

MYLK3 ITPR2 ITPR3

4.16e-03178263M2890
PathwayREACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS

ITPR2 ITPR3

4.25e-0353262MM15716
PathwayREACTOME_ION_HOMEOSTASIS

ITPR2 ITPR3

4.41e-0354262MM15202
PathwayREACTOME_ION_HOMEOSTASIS

ITPR2 ITPR3

4.41e-0354262M27460
PathwayREACTOME_G_PROTEIN_MEDIATED_EVENTS

ITPR2 ITPR3

4.41e-0354262M26911
PathwayKEGG_MEDICUS_REFERENCE_RTK_PLCG_ITPR_SIGNALING_PATHWAY

ITPR2 ITPR3

4.57e-0355262M47952
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

ITPR2 ITPR3

5.60e-0361262MM15071
PathwayREACTOME_CA2_PATHWAY

ITPR2 ITPR3

5.78e-0362262M27321
PathwayREACTOME_ESTROGEN_DEPENDENT_GENE_EXPRESSION

KAT2B GREB1

5.96e-0363262MM15613
PathwayREACTOME_MUSCLE_CONTRACTION

KAT2B ITPR2 ITPR3

5.99e-03203263M5485
Pubmed

Phylogenetic and molecular characterization of the splicing factor RBM4.

RBM4B RBM4

6.71e-07229223527094
Pubmed

Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin.

ITPR2 ITPR3

6.71e-0722929065779
Pubmed

Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve.

ITPR2 ITPR3

6.71e-07229217496801
Pubmed

IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism.

ITPR2 ITPR3

6.71e-07229216195467
Pubmed

The LARK/RBM4a protein is highly expressed in cerebellum as compared to cerebrum.

RBM4B RBM4

6.71e-07229218708123
Pubmed

Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye.

ITPR2 ITPR3

6.71e-07229224901844
Pubmed

Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant.

ITPR2 ITPR3

6.71e-07229215632133
Pubmed

Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.

ITPR2 ITPR3

6.71e-07229233854148
Pubmed

Inositol (1,4,5)-trisphosphate receptor links to filamentous actin are important for generating local Ca2+ signals in pancreatic acinar cells.

ITPR2 ITPR3

6.71e-07229215713744
Pubmed

Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors.

ITPR2 ITPR3

6.71e-07229219528657
Pubmed

Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction.

ITPR2 ITPR3

6.71e-0722928063813
Pubmed

Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors.

ITPR2 ITPR3

6.71e-0722928081734
Pubmed

Rescue of calcineurin Aα(-/-) mice reveals a novel role for the α isoform in the salivary gland.

ITPR2 ITPR3

2.01e-06329221435446
Pubmed

Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.

ITPR2 ITPR3

2.01e-06329231979185
Pubmed

Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.

ITPR2 ITPR3

2.01e-06329210874040
Pubmed

Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.

ITPR2 ITPR3

2.01e-0632929808793
Pubmed

Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.

ITPR2 ITPR3

2.01e-06329224904548
Pubmed

Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.

ITPR2 ITPR3

2.01e-06329220395455
Pubmed

Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.

ITPR2 ITPR3

2.01e-06329217327232
Pubmed

Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.

ITPR2 ITPR3

2.01e-06329217437169
Pubmed

Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.

ITPR2 ITPR3

2.01e-06329216014380
Pubmed

Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.

ITPR2 ITPR3

2.01e-06329218194433
Pubmed

RBM4 Regulates Neuronal Differentiation of Mesenchymal Stem Cells by Modulating Alternative Splicing of Pyruvate Kinase M.

RBM4B RBM4

2.01e-06329227821480
Pubmed

Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.

ITPR2 ITPR3

2.01e-06329217890015
Pubmed

Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.

ITPR2 ITPR3

2.01e-06329218547250
Pubmed

Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.

ITPR2 ITPR3

2.01e-06329236350267
Pubmed

IP3 receptors regulate vascular smooth muscle contractility and hypertension.

ITPR2 ITPR3

2.01e-06329227777977
Pubmed

The versatility and universality of calcium signalling.

ITPR2 ITPR3

2.01e-06329211413485
Pubmed

Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.

ITPR2 ITPR3

2.01e-06329223983250
Pubmed

Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.

ITPR2 ITPR3

2.01e-0632929858485
Pubmed

Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.

ITPR2 ITPR3

2.01e-06329226009177
Pubmed

Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.

ITPR2 ITPR3

2.01e-06329217581770
Pubmed

Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.

ITPR2 ITPR3

2.01e-06329220427533
Pubmed

Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.

ITPR2 ITPR3

2.01e-06329218241669
Pubmed

A novel splicing regulator shares a nuclear import pathway with SR proteins.

RBM4B RBM4

2.01e-06329212628928
Pubmed

Receptor-activated single channels in intact human platelets.

ITPR2 ITPR3

2.01e-0632921693919
Pubmed

Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.

ITPR2 ITPR3

2.01e-06329219068129
Pubmed

Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.

ITPR2 ITPR3

2.01e-06329223955339
Pubmed

Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.

ITPR2 ITPR3

4.02e-06429225215520
Pubmed

Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor.

ITPR2 ITPR3

4.02e-06429217925404
Pubmed

Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.

ITPR2 ITPR3

4.02e-06429221424589
Pubmed

IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway.

ITPR2 ITPR3

4.02e-06429228419336
Pubmed

IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis.

ITPR2 ITPR3

4.02e-06429226193638
Pubmed

Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.

ITPR2 ITPR3

4.02e-06429211163362
Pubmed

IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming.

ITPR2 ITPR3

4.02e-06429235494252
Pubmed

Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function.

ITPR2 ITPR3

4.02e-06429228615414
Pubmed

Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.

ITPR2 ITPR3

4.02e-06429210828023
Pubmed

Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors.

PCSK1 CSHL1 INSM1

6.29e-064329324227653
Pubmed

InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences.

ITPR2 ITPR3

6.70e-06529221568942
Pubmed

Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through IP3 receptors.

ITPR2 ITPR3

6.70e-06529221436055
Pubmed

Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.

ITPR2 ITPR3

1.00e-05629223463619
Pubmed

Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.

ITPR2 ITPR3

1.00e-05629221762810
Pubmed

IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.

ITPR2 ITPR3

1.00e-05629216844763
Pubmed

A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.

ITPR2 ITPR3

1.00e-05629220519450
Pubmed

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.

ITPR2 ITPR3

1.00e-05629225966694
Pubmed

RBM4 promotes neuronal differentiation and neurite outgrowth by modulating Numb isoform expression.

RBM4B RBM4

1.00e-05629227009199
Pubmed

LARK activates posttranscriptional expression of an essential mammalian clock protein, PERIOD1.

RBM4B RBM4

1.41e-05729217264215
Pubmed

Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.

ITPR2 ITPR3

1.41e-05729211860456
Pubmed

Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.

ITPR2 ITPR3

1.41e-05729222495310
Pubmed

A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.

EPRS1 LRPAP1 LAMP2 RBM4B RBM4 GTF3C3

1.86e-0568629628380382
Pubmed

Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.

ITPR2 ITPR3

1.87e-05829219033399
Pubmed

Activation of TrkB signaling mitigates cerebellar anomalies caused by Rbm4-Bdnf deficiency.

RBM4B RBM4

2.41e-05929237670183
Pubmed

Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.

ITPR2 ITPR3

2.41e-05929225737585
Pubmed

Type 1 and 3 inositol trisphosphate receptors are required for extra-embryonic vascular development.

ITPR2 ITPR3

3.68e-051129227514653
Pubmed

RBM4 Modulates Radial Migration via Alternative Splicing of Dab1 during Cortex Development.

RBM4B RBM4

4.41e-051229229581187
Pubmed

Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II + Type I/II Oligodendrocytes and the Sizes of Myelin Fibers.

ITPR2 ITPR3

6.07e-051429234630045
Pubmed

Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle.

ITPR2 ITPR3

7.00e-051529228578927
Pubmed

Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis.

APCDD1 PRDM1

8.00e-051629222115758
Pubmed

RBM4 promotes pancreas cell differentiation and insulin expression.

RBM4B RBM4

9.06e-051729223129807
Pubmed

The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity.

ITPR2 ITPR3

1.53e-042229211696558
Pubmed

Genome-wide microarray comparison reveals downstream genes of Pax6 in the developing mouse cerebellum.

APCDD1 INSM1

1.68e-042329222817342
Pubmed

Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.

ITPR2 ITPR3

1.83e-042429210843712
Pubmed

LINC01554-Mediated Glucose Metabolism Reprogramming Suppresses Tumorigenicity in Hepatocellular Carcinoma via Downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway.

ARHGAP1 EPRS1 ITPR2

2.25e-0414229330809309
Pubmed

SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.

GTF3C3 TONSL ITPR2

2.65e-0415029330154076
Pubmed

Atm deficiency in the DNA polymerase β null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation.

ITPR2 ITPR3

2.69e-042929232123907
Pubmed

Casein kinase 1α is required to maintain murine hypothalamic pro-opiomelanocortin expression.

PCSK1 CSHL1

3.08e-043129237168577
Pubmed

The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells.

PCSK1 INSM1

3.49e-043329216951258
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

LRPAP1 NCEH1 LAMP2 RBM4 GTF3C3 ITPR2

4.02e-04120129635696571
Pubmed

Comparative gene expression analysis of genital tubercle development reveals a putative appendicular Wnt7 network for the epidermal differentiation.

APCDD1 PRDM1

4.39e-043729220510229
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

ITPR2 ITPR3

4.63e-043829230786075
Pubmed

FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.

ARHGAP1 LRPAP1 ITPR2 ITPR3

5.89e-0446829431056421
Pubmed

PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation.

EPRS1 RBM4 GTF3C3

7.77e-0421729331685992
Cytoband11q13

RBM4B RBM4

2.54e-0311829211q13
GeneFamilyInositol 1,4,5-triphosphate receptors|Protein phosphatase 1 regulatory subunits

ITPR2 ITPR3

3.85e-063212297
GeneFamilyZinc fingers CCHC-type|RNA binding motif containing

RBM4B RBM4

3.79e-042521274
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

CFAP70 GTF3C3

7.78e-03115212769
GeneFamilyRNA binding motif containing

RBM4B RBM4

2.50e-02213212725
CoexpressionRIZKI_TUMOR_INVASIVENESS_3D_DN

KAT2B HERC1 RBM4 TONSL ITPR2

9.37e-06262295M11472
ToppCellCOPD-Epithelial-PNEC|COPD / Disease state, Lineage and Cell class

PCSK1 GREB1 INSM1

1.48e-041592936018124980c55190928409f3bf41d846a118954a
ToppCellCOPD-Epithelial-PNEC|World / Disease state, Lineage and Cell class

PCSK1 GREB1 INSM1

1.51e-04160293cdea93317b0ebb801ddbe73bca6149ce2c727f16
ToppCellBronchial_Brush-Epithelial-Ionocytes|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

PCSK1 INSM1 ITPR2

1.90e-04173293e1de849dcd96063136bdac87e050ddbd55cabdcc
ToppCell3'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARHGAP1 SIM2 ITPR2

2.10e-04179293906555ce2ca264a0215b120c7ff7c9b411de6a34
ToppCellwk_20-22-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

PCSK1 GREB1 SIM2

2.10e-0417929306f92c884189197c86793191c05f65e34925c097
ToppCellCOPD-Epithelial-PNEC|Epithelial / Disease state, Lineage and Cell class

PCSK1 GREB1 INSM1

2.10e-04179293988d0853c391da1e5004f73f3678047418d3f6d3
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CFAP70 SIM2 ITPR2

2.24e-0418329331ab55d5f3639f5964541d5eae23044dbda3356e
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NCEH1 LAMP2 GREB1

2.27e-04184293840fac463665ed18752f402f7d1ef2e5052bdf74
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

NEK1 GREB1 ITPR2

2.27e-0418429367164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell5'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK1 GREB1 INSM1

2.35e-04186293ea2c8e0df038a00062d2098b4a9ac85141b9a728
ToppCell5'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine-Neuroendocrine_L.0.7.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK1 GREB1 INSM1

2.35e-04186293714765585a644bf9817ab6eb3001b43b3c2d2410
ToppCell5'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK1 GREB1 INSM1

2.35e-041862932fab7abed16a894afdd0207e86fc43a25a77fb9e
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CFAP70 SIM2 ITPR2

2.38e-04187293b93cf4dfe8ffb89348ee7bccc9f284189f7240a2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NCEH1 SIM2 ITPR3

2.38e-0418729387b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NCEH1 SIM2 ITPR3

2.38e-0418729342a1267bfc27b4460b8409ada580a87c4385841c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NCEH1 SIM2 ITPR3

2.38e-0418729364afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK1 INSM1 ITPR2

2.42e-041882931f912ea015f50570e848259d948a0ba682d64bb4
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NCEH1 SIM2 ITPR3

2.46e-04189293aadb7a2de4cbe7f0958651f2739bba430b93f5c1
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NCEH1 SIM2 ITPR3

2.46e-041892938977f3295b7df7c7474b3f371de90a82ae4bb50c
ToppCellcellseq-Epithelial-Epithelial_Neuro-Secretory-PNEC-PNEC|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PCSK1 GREB1 INSM1

2.54e-04191293146cfd4daa2878536b4f381564c787919ad855a8
ToppCellcellseq-Epithelial-Epithelial_Neuro-Secretory-PNEC|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PCSK1 GREB1 INSM1

2.54e-0419129312ea07565dc0e62cade9fbab4a2d763e47a341e3
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KAT2B APCDD1 ITPR2

2.54e-04191293f3158cedf67e3b90aa94ea1f61c72c33aaa2d5ba
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-6|TCGA-Stomach / Sample_Type by Project: Shred V9

EPRS1 NCEH1 PARP9

2.58e-041922934e689bca7a242f8482e25f273656e2caba8821c0
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFAP70 SIM2 ITPR2

2.58e-04192293ee27d27e3d269764dbe8711d0b37ff9331a298a9
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NCEH1 SIM2 ITPR3

2.62e-04193293f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NCEH1 SIM2 ITPR3

2.62e-0419329342df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCellcellseq-Epithelial-Epithelial_Neuro-Secretory|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PCSK1 GREB1 INSM1

2.62e-0419329325b1e5a04724023918c8939109a92b35582d5e5c
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NCEH1 SIM2 ITPR3

2.66e-04194293e577d9e88390b36b5a09b97fe1026089892275a3
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NCEH1 SIM2 ITPR3

2.70e-04195293938b31dbf1674ee6fd0123bc88391ddcaf151217
ToppCell390C-Myeloid-Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

LRPAP1 NCEH1 LAMP2

2.70e-04195293ba494be431916d43c1d480f65bed674c0722c710
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NCEH1 SIM2 ITPR3

2.70e-04195293d39e9e6544f49e677ebe528c6fe60b99a3630e30
ToppCell10x3'2.3-week_17-19-Hematopoietic-erythroid-mid_erythroid|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

NCEH1 KAT2B HERC1

2.74e-0419629351c48944149a89b98011a50fe81ca6664d5f0d44
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRPAP1 NCEH1 LAMP2

2.74e-041962935fe6534af65d43eeacd4b031310242b4f706008b
ToppCelltumor_Lung-B_lymphocytes-MALT_B_cells|B_lymphocytes / Location, Cell class and cell subclass

LRPAP1 LAMP2 PRDM1

2.74e-041962931f63dba9d226e4a42d9bee7258580a1e547c0e92
ToppCell(3)_MNP-(3)_Macrophage_MARCOpos|(3)_MNP / Lung cell shreds - cell class (v4) and cell subclass (v4)

LRPAP1 NCEH1 LAMP2

2.74e-04196293a4c9f46ff75dbdd43ad369ceda604fb1650d8a9a
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-6_mon-Macroglial-Astroglia|6_mon / Sample Type, Dataset, Time_group, and Cell type.

LAMP2 APCDD1 ITPR2

2.78e-041972933f088eb29197bc575400d6dafd8083e69e4a149f
ToppCell343B-Myeloid-Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

LRPAP1 NCEH1 LAMP2

2.78e-041972931b6f7a62b7fcfd55c25c5840353eed7183050860
ToppCellSepsis-ICU-NoSEP-Lymphocyte-B-Plasmablast|ICU-NoSEP / Disease, condition lineage and cell class

NEK1 GTPBP3 PRDM1

2.78e-041972938f35f9741086a38f0e594dce0547b575946f52bb
ToppCellMNPs-Macrophages|MNPs / lung cells shred on cell class, cell subclass, sample id

LRPAP1 NCEH1 LAMP2

2.78e-0419729303d74643646dce5d3a278a1ee48c390d13a7889c
ToppCellLAM-Myeloid-Macrophage|Myeloid / Condition, Lineage and Cell class

LRPAP1 NCEH1 LAMP2

2.78e-04197293355fe286609df2ded973952f1856bbc5f437cfd0
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-6_mon-Macroglial|6_mon / Sample Type, Dataset, Time_group, and Cell type.

LAMP2 APCDD1 ITPR2

2.78e-04197293965d5a3f8c9b12cb8a8d3429702ae29ebd8c6122
ToppCellnormal_Lung-Myeloid_cells-Alveolar_Mac|Myeloid_cells / Location, Cell class and cell subclass

LRPAP1 NCEH1 LAMP2

2.82e-04198293189b787d51985b13d645bdb64def2de0a214d55b
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRPAP1 NCEH1 LAMP2

2.82e-041982933dafa555bd01e6d4b5ffbcdd542d738905140801
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRPAP1 NCEH1 LAMP2

2.82e-04198293768df928a3265dbe7cce2acea07b2f6d6b709642
ToppCellBronchial_Brush-Immune-Luminal_Macrophages|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

LRPAP1 NCEH1 LAMP2

2.82e-0419829377f41f0e0895b7c732bab1fd2e047f2ed31cbd9d
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRPAP1 NCEH1 LAMP2

2.82e-041982931774dd36315a04c4cdcef2cc674204e4ab9c175b
ToppCellcellseq-Immune-Immune_Myeloid-AM|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LRPAP1 NCEH1 LAMP2

2.86e-04199293298302123a2b3815ed98130fa1a229e56e8ab77b
ToppCell3'_v3-Lung-Myeloid_Mac-Alveolar_macrophages|Lung / Manually curated celltypes from each tissue

LRPAP1 NCEH1 LAMP2

2.86e-04199293eec1b086e5e8b9b0e1770dd269ca903f713d99a8
ToppCellcellseq-Immune-Immune_Myeloid-AM-AM|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LRPAP1 NCEH1 LAMP2

2.86e-04199293255cf629351f35e516a5271d8758c29168ebd0cf
ToppCell3'_v3-Lung-Myeloid_Mac|Lung / Manually curated celltypes from each tissue

LRPAP1 NCEH1 LAMP2

2.86e-041992931677aaee5b7f5f262e27df5d9f1bdf6e21e3d804
ToppCellBAL-Control-cDC_0|Control / Compartment, Disease Groups and Clusters

LRPAP1 NCEH1 LAMP2

2.86e-041992934518ffa51ead9da1ddf07bf048b18602e50f0f84
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRPAP1 NCEH1 LAMP2

2.86e-04199293eeb936e52b0ae2e326b425a2c02be38aa62aece4
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRPAP1 NCEH1 LAMP2

2.86e-0419929303a3303d53005cf056bdd4971c393f20f980a201
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRPAP1 NCEH1 LAMP2

2.86e-04199293ad2681b71fdf9644c9e639fca4beb9be37e27638
ToppCellmLN-Macrophage-LYVE1_Macrophage|Macrophage / Region, Cell class and subclass

LRPAP1 LAMP2 HERC1

2.90e-04200293e3c15e0e1c2602b0cc9ab8cc50c978d265350c94
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated|COVID-19_Mild / Disease, condition lineage and cell class

KAT2B PARP9 PRDM1

2.90e-042002932281debd86e5d92e8fe0397aec9ef670800f7471
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

EPRS1 LRPAP1 LAMP2

1.02e-0450203GAVISH_3CA_MALIGNANT_METAPROGRAM_10_PROTEIN_MATURATION
Drugadenophostin A

ITPR2 ITPR3

1.57e-062292ctd:C085029
Drug5211181; Down 200; 12uM; MCF7; HT_HG-U133A_EA

ARHGAP1 NEK1 KAT2B RBM4 ITPR3

4.74e-06198295950_DN
Diseaseautosomal dominant cerebellar ataxia (implicated_via_orthology)

ITPR2 ITPR3

6.12e-0512292DOID:1441 (implicated_via_orthology)
Diseasehypertrophic cardiomyopathy (implicated_via_orthology)

LAMP2 GTPBP3

3.72e-0429292DOID:11984 (implicated_via_orthology)
Diseaseamyotrophic lateral sclerosis (is_implicated_in)

NEK1 ITPR2

4.54e-0432292DOID:332 (is_implicated_in)
Diseaseglucose measurement

PCSK1 ARHGAP1 HERC1 ITPR3

4.98e-04380294EFO_0004468
Diseasedrug dependence

KAT2B SLC25A16

5.44e-0435292EFO_0003890
Diseaseobesity (implicated_via_orthology)

PCSK1 ITPR2 ITPR3

1.21e-03215293DOID:9970 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
HHLQGCLDALGHYKQ

GTPBP3

436

Q969Y2
SHNHDALLKNYGLLH

CSHL1

181

Q14406
HNHYQKQLEIAHEKL

LRPAP1

291

P30533
KVLLQAHNHHYKHLG

SLC25A16

61

P16260
AIRNLHHYKLHGVNI

RBM4

51

Q9BWF3
QNHHIIENNHILYLG

PARP9

541

Q8IXQ6
HNIYILAHQLARHNK

ITPR2

2106

Q14571
GNQALLHKHLHLFLT

ITPR3

1241

Q14573
GSSVHNILHIKQLYH

LIPN

286

Q5VXI9
LGNEHQHLYAKILHL

NEK1

1231

Q96PY6
QLLLEKFLQHHSHLF

GREB1

1811

Q4ZG55
NHLKEYHIKHDILNF

KAT2B

591

Q92831
HKHLQLLLPHATDIY

HERC1

1016

Q15751
YLHQHYILHLDLKPE

MYLK3

626

Q32MK0
HYLGLSHHLLALNFI

NCEH1

51

Q6PIU2
LVLLAYFIGLKHHHA

LAMP2

391

P13473
AIRNLHHYKLHGVNI

RBM4B

51

Q9BQ04
YRHPGHIHKLLAQQL

MCAT

306

Q8IVS2
LFRDIGHHLIHNNKI

CFAP70

381

Q5T0N1
LIRVEKQYLHHNLDH

APCDD1

211

Q8J025
KQYLHHNLDHLVEEL

APCDD1

216

Q8J025
YLRKHLLAHHQALQA

INSM1

381

Q01101
HIGHAKAALLNQHYQ

EPRS1

211

P07814
SHQLDHSKLLGYLKH

ARHGAP1

96

Q07960
HLRYAHHLLLVKGQV

SIM2

276

Q14190
GFTQLAHLQKHYLVH

PRDM1

611

O75626
LHQLGLIHLAIHYYQ

GTF3C3

821

Q9Y5Q9
ALQHQHQYLELAHSL

TONSL

86

Q96HA7
GKIFNQHILLTDHIH

ZNF713

241

Q8N859
IGSLENHYLFKHKNH

PCSK1

61

P29120