Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	XCR1 HTR4 GPR52 IL18RAP CRHR2 OR2L2 TAS2R13 ADRA2C ADRB1 IGF2R PTPRO PKD1 FCRLB CD69 LRP5 HRH4 ROS1 FGFR2 TAS2R45	5.61e-05	1353	103	19	GO:0004888
GeneOntologyMolecularFunction	G protein-coupled amine receptor activity	HTR4 ADRA2C ADRB1 HRH4	5.84e-05	41	103	4	GO:0008227
GeneOntologyMolecularFunction	alpha-2A adrenergic receptor binding	ADRA2C ADRB1	2.61e-04	5	103	2	GO:0031694
GeneOntologyMolecularFunction	piRNA binding	PIWIL4 MOV10L1	3.90e-04	6	103	2	GO:0034584
MousePheno	abnormal cranial cartilage development	TMEM107 PKD1 FGFR2	1.59e-05	9	82	3	MP:0030467
MousePheno	short presphenoid bone	TMEM107 PKD1	3.40e-05	2	82	2	MP:0004451
Domain	PKD/REJ-like	PKDREJ KIAA0319 PKD1	3.13e-06	6	102	3	IPR002859
Domain	REJ	PKDREJ KIAA0319 PKD1	3.13e-06	6	102	3	PF02010
Domain	ADR_fam	HTR4 ADRA2C ADRB1	1.85e-05	10	102	3	IPR002233
Domain	REJ	PKDREJ PKD1	1.76e-04	4	102	2	PS51111
Domain	REJ_dom	PKDREJ PKD1	1.76e-04	4	102	2	IPR014010
Domain	-	COL18A1 PLA2R1 CLEC4E PKD1 CD69	1.91e-04	97	102	5	3.10.100.10
Domain	Quinoprotein_ADH-like_supfam	AHCTF1 EML3 UTP4 EML1	2.00e-04	53	102	4	IPR011047
Domain	C-type_lectin-like/link	COL18A1 PLA2R1 CLEC4E PKD1 CD69	2.10e-04	99	102	5	IPR016186
Domain	CTDL_fold	COL18A1 PLA2R1 CLEC4E PKD1 CD69	3.01e-04	107	102	5	IPR016187
Domain	HELP	EML3 EML1	4.37e-04	6	102	2	PF03451
Domain	HELP	EML3 EML1	4.37e-04	6	102	2	IPR005108
Domain	WD40	PEX7 WDR5 CFAP43 EML3 UTP4 IFT80 EML1	6.71e-04	268	102	7	SM00320
Domain	WD40_repeat	PEX7 WDR5 CFAP43 EML3 UTP4 IFT80 EML1	7.32e-04	272	102	7	IPR001680
Domain	WD_REPEATS_1	PEX7 WDR5 CFAP43 EML3 UTP4 IFT80 EML1	8.32e-04	278	102	7	PS00678
Domain	WD_REPEATS_2	PEX7 WDR5 CFAP43 EML3 UTP4 IFT80 EML1	8.49e-04	279	102	7	PS50082
Domain	WD_REPEATS_REGION	PEX7 WDR5 CFAP43 EML3 UTP4 IFT80 EML1	8.49e-04	279	102	7	PS50294
Domain	C_TYPE_LECTIN_1	PLA2R1 CLEC4E PKD1 CD69	9.65e-04	80	102	4	PS00615
Domain	PKD/Chitinase_dom	KIAA0319 PKD1	1.04e-03	9	102	2	IPR022409
Domain	PKD	KIAA0319 PKD1	1.04e-03	9	102	2	SM00089
Domain	Lectin_C	PLA2R1 CLEC4E PKD1 CD69	1.16e-03	84	102	4	PF00059
Domain	CLECT	PLA2R1 CLEC4E PKD1 CD69	1.16e-03	84	102	4	SM00034
Domain	C_TYPE_LECTIN_2	PLA2R1 CLEC4E PKD1 CD69	1.21e-03	85	102	4	PS50041
Domain	WD40_repeat_dom	PEX7 WDR5 CFAP43 EML3 UTP4 IFT80 EML1	1.22e-03	297	102	7	IPR017986
Domain	C-type_lectin-like	PLA2R1 CLEC4E PKD1 CD69	1.26e-03	86	102	4	IPR001304
Domain	PKD	KIAA0319 PKD1	1.57e-03	11	102	2	PS50093
Domain	PKD_dom	KIAA0319 PKD1	1.57e-03	11	102	2	IPR000601
Domain	PKD_channel	PKDREJ PKD1	1.57e-03	11	102	2	PF08016
Domain	PKD1_2_channel	PKDREJ PKD1	1.57e-03	11	102	2	IPR013122
Domain	-	KIAA0319 PKD1	1.57e-03	11	102	2	2.60.40.670
Domain	APOBEC_N	APOBEC3D APOBEC3G	1.88e-03	12	102	2	PF08210
Domain	APOBEC_N	APOBEC3D APOBEC3G	1.88e-03	12	102	2	IPR013158
Domain	-	PLA2R1 IGF2R	2.22e-03	13	102	2	2.10.10.10
Domain	-	PEX7 WDR5 CFAP43 EML3 UTP4 IFT80 EML1	2.34e-03	333	102	7	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	PEX7 WDR5 CFAP43 EML3 UTP4 IFT80 EML1	2.42e-03	335	102	7	IPR015943
Domain	FN_type2_col-bd	PLA2R1 IGF2R	2.57e-03	14	102	2	IPR000562
Domain	FN2_2	PLA2R1 IGF2R	2.57e-03	14	102	2	PS51092
Domain	APOBEC/CMP_deaminase_Zn-bd	APOBEC3D APOBEC3G	2.57e-03	14	102	2	IPR016192
Domain	ATPase_dyneun-rel_AAA	DYNC2H1 MDN1	2.57e-03	14	102	2	IPR011704
Domain	fn2	PLA2R1 IGF2R	2.57e-03	14	102	2	PF00040
Domain	FN2_1	PLA2R1 IGF2R	2.57e-03	14	102	2	PS00023
Domain	FN2	PLA2R1 IGF2R	2.57e-03	14	102	2	SM00059
Domain	AAA_5	DYNC2H1 MDN1	2.57e-03	14	102	2	PF07728
Domain	LY	LRP5 ROS1	2.96e-03	15	102	2	SM00135
Domain	LDLR_classB_rpt	LRP5 ROS1	2.96e-03	15	102	2	IPR000033
Domain	N2O_reductase_N	PEX7 EML1	2.96e-03	15	102	2	IPR011045
Domain	WD40	PEX7 WDR5 EML3 UTP4 IFT80 EML1	2.98e-03	259	102	6	PF00400
Domain	Cytidine_deaminase-like	APOBEC3D APOBEC3G	3.81e-03	17	102	2	IPR016193
Domain	CYT_DCMP_DEAMINASES_1	APOBEC3D APOBEC3G	3.81e-03	17	102	2	PS00903
Domain	CMP_dCMP_Zn-bd	APOBEC3D APOBEC3G	3.81e-03	17	102	2	IPR002125
Domain	LH2	PKDREJ PKD1	4.27e-03	18	102	2	SM00308
Domain	Ig-like_fold	NRG1 FSD2 IL18RAP KIAA0319 LRIG2 PTPRO NEGR1 FCRLB ROS1 FGFR2	5.22e-03	706	102	10	IPR013783
Domain	PLAT	PKDREJ PKD1	5.80e-03	21	102	2	PS50095
Domain	-	PKDREJ PKD1	5.80e-03	21	102	2	2.60.60.20
Domain	PLAT	PKDREJ PKD1	5.80e-03	21	102	2	PF01477
Pathway	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	HTR4 ADRA2C ADRB1 HRH4	9.14e-05	42	80	4	M5868
Pathway	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	HTR4 ADRA2C ADRB1 HRH4	9.14e-05	42	80	4	MM14971
Pathway	WP_BARDETBIEDL_SYNDROME	DYNC2H1 USP9X TMEM107 PKD1 IFT80	1.41e-04	88	80	5	M45557
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DYNC2H1 PEG10 AHCTF1 GRAMD1A SNX29 LRIG2 PASK COL18A1 IGF2R MDN1 SACS UTP4 MRPL38 IFT80 LAS1L MAP4K4 SNRNP200 XRCC6	4.15e-07	1487	104	18	33957083
Pubmed	A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.	EP400 MARS1 AHCTF1 SMC6 UTP4 LTN1 PITPNM3 SYVN1 TVP23A	4.92e-06	419	104	9	28700943
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	EP400 MARS1 USP9X EML3 MDN1 PLEC LAS1L SNRNP200	7.37e-06	332	104	8	32786267
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	EP400 EML3 PASK IGF2R UTP4 PKD1 LTN1 CCAR1 PLEC MAP4K4	7.75e-06	564	104	10	21565611
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	PIK3AP1 AHCTF1 SMC6 MDN1 UTP4 PLEC LAS1L SNRNP200	8.76e-06	340	104	8	29478914
Pubmed	Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis.	WDR5 PASK	8.86e-06	2	104	2	27661449
Pubmed	Impact of the Motor and Tail Domains of Class III Myosins on Regulating the Formation and Elongation of Actin Protrusions.	MYO3A MYO3B	8.86e-06	2	104	2	27582493
Pubmed	Multiple interactions between the alpha 2C- and beta1-adrenergic receptors influence heart failure survival.	ADRA2C ADRB1	8.86e-06	2	104	2	18947427
Pubmed	Beta-1-adrenoceptor genetic variants and ethnicity independently affect response to beta-blockade.	ADRA2C ADRB1	8.86e-06	2	104	2	18794726
Pubmed	Mouse class III myosins: kinase activity and phosphorylation sites.	MYO3A MYO3B	8.86e-06	2	104	2	21895655
Pubmed	No positive association between adrenergic receptor variants of alpha2cDel322-325, beta1Ser49, beta1Arg389 and the risk for heart failure in the Japanese population.	ADRA2C ADRB1	8.86e-06	2	104	2	16187973
Pubmed	Adrenergic receptor polymorphisms and prevention of ventricular arrhythmias with bucindolol in patients with chronic heart failure.	ADRA2C ADRB1	8.86e-06	2	104	2	23275278
Pubmed	Synergistic polymorphisms of beta1 and alpha2C-adrenergic receptors and the influence on left ventricular ejection fraction response to beta-blocker therapy in heart failure.	ADRA2C ADRB1	8.86e-06	2	104	2	17496726
Pubmed	Adrenergic receptor genotype influences heart failure severity and β-blocker response in children with dilated cardiomyopathy.	ADRA2C ADRB1	8.86e-06	2	104	2	25406899
Pubmed	Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure.	ADRA2C ADRB1	8.86e-06	2	104	2	12374873
Pubmed	Conditional inactivation of Miwi2 reveals that MIWI2 is only essential for prospermatogonial development in mice.	PIWIL4 MOV10L1	8.86e-06	2	104	2	24464225
Pubmed	Beta1- and alpha2c-adrenoreceptor variants as predictors of clinical aspects of dilated cardiomyopathy in people of African ancestry.	ADRA2C ADRB1	8.86e-06	2	104	2	18776959
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	CUL1 EP400 MARS1 AHCTF1 WDR5 DCK MDN1 UTP4 LTN1 CCAR1 PLEC LAS1L DHX34 SNRNP200 XRCC6	1.21e-05	1353	104	15	29467282
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	NRG1 DYNC2H1 USP9X PEG10 SMC6 POMT1 KIAA0319 PASK IGF2R MDN1 LTN1 FITM2 EPCAM	1.73e-05	1061	104	13	33845483
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	EP400 PASK MYO3A MDN1 XPO6 CCAR1 PLEC MAP4K4 SNRNP200 XRCC6 KDM4B	2.11e-05	774	104	11	15302935
Pubmed	The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification.	USP9X PEG10	2.65e-05	3	104	2	30951545
Pubmed	Adrenergic receptor polymorphisms in patients with stress (tako-tsubo) cardiomyopathy.	ADRA2C ADRB1	2.65e-05	3	104	2	19167638
Pubmed	LncRNA ANRIL acts as a modular scaffold of WDR5 and HDAC3 complexes and promotes alteration of the vascular smooth muscle cell phenotype.	WDR5 HDAC3	2.65e-05	3	104	2	32513988
Pubmed	Neural control of heart rate is an arrhythmia risk modifier in long QT syndrome.	ADRA2C ADRB1	2.65e-05	3	104	2	18308161
Pubmed	Polymorphisms of adrenoceptors are not associated with an increased risk of adverse event in heart failure: a MERIT-HF substudy.	ADRA2C ADRB1	2.65e-05	3	104	2	19477404
Pubmed	Myosin III-mediated cross-linking and stimulation of actin bundling activity of Espin.	MYO3A MYO3B	2.65e-05	3	104	2	26785147
Pubmed	APOBEC3DE Antagonizes Hepatitis B Virus Restriction Factors APOBEC3F and APOBEC3G.	APOBEC3D APOBEC3G	2.65e-05	3	104	2	27289067
Pubmed	Mutations in the MOV10L1 ATP Hydrolysis Motif Cause piRNA Biogenesis Failure and Male Sterility in Mice.	PIWIL4 MOV10L1	2.65e-05	3	104	2	27655786
Pubmed	Myosin IIIB uses an actin-binding motif in its espin-1 cargo to reach the tips of actin protrusions.	MYO3A MYO3B	2.65e-05	3	104	2	22264607
Pubmed	APOBEC3D and APOBEC3F potently promote HIV-1 diversification and evolution in humanized mouse model.	APOBEC3D APOBEC3G	2.65e-05	3	104	2	25330146
Pubmed	Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n.	APOBEC3D APOBEC3G	2.65e-05	3	104	2	22807680
Pubmed	Genetic variation in alpha2-adrenoreceptors and heart rate recovery after exercise.	ADRA2C ADRB1	2.65e-05	3	104	2	26058836
Pubmed	Interaction between cardiac sympathetic drive and heart rate in heart failure: modulation by adrenergic receptor genotype.	ADRA2C ADRB1	2.65e-05	3	104	2	15542284
Pubmed	Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol.	ADRA2C ADRB1	2.65e-05	3	104	2	18702968
Pubmed	Genetic biomarkers of life-threatening pheochromocytoma-induced cardiomyopathy.	ADRA2C ADRB1	2.65e-05	3	104	2	35258481
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	USP9X AHCTF1 IGF2R MDN1 UTP4 CCAR1 PLEC LAS1L SNRNP200 XRCC6	2.72e-05	653	104	10	22586326
Pubmed	Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection.	CUL1 APOBEC3G HDAC3	3.32e-05	21	104	3	22190037
Pubmed	APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis.	APOBEC3D APOBEC3G	5.29e-05	4	104	2	21985787
Pubmed	Distinct determinants in HIV-1 Vif and human APOBEC3 proteins are required for the suppression of diverse host anti-viral proteins.	APOBEC3D APOBEC3G	5.29e-05	4	104	2	19088851
Pubmed	Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like.	MYO3A MYO3B	5.29e-05	4	104	2	26926603
Pubmed	Reversed functional organization of mouse and human APOBEC3 cytidine deaminase domains.	APOBEC3D APOBEC3G	5.29e-05	4	104	2	17020885
Pubmed	A novel HIV-1 restriction factor that is biologically distinct from APOBEC3 cytidine deaminases in a human T cell line CEM.NKR.	APOBEC3D APOBEC3G	5.29e-05	4	104	2	19344514
Pubmed	The incorporation of APOBEC3 proteins into murine leukemia viruses.	APOBEC3D APOBEC3G	5.29e-05	4	104	2	18572219
Pubmed	A patch of positively charged amino acids surrounding the human immunodeficiency virus type 1 Vif SLVx4Yx9Y motif influences its interaction with APOBEC3G.	APOBEC3D APOBEC3G	5.29e-05	4	104	2	19535450
Pubmed	Small molecular compounds inhibit HIV-1 replication through specifically stabilizing APOBEC3G.	APOBEC3D APOBEC3G	5.29e-05	4	104	2	20363737
Pubmed	HIV-1 Vif versus the APOBEC3 cytidine deaminases: an intracellular duel between pathogen and host restriction factors.	APOBEC3D APOBEC3G	5.29e-05	4	104	2	20538015
Pubmed	APOBEC3G restricts HIV-1 to a greater extent than APOBEC3F and APOBEC3DE in human primary CD4+ T cells and macrophages.	APOBEC3D APOBEC3G	5.29e-05	4	104	2	23097438
Pubmed	HIV restriction by APOBEC3 in humanized mice.	APOBEC3D APOBEC3G	5.29e-05	4	104	2	23555255
Pubmed	The Cytidine Deaminase APOBEC3G Contributes to Cancer Mutagenesis and Clonal Evolution in Bladder Cancer.	APOBEC3D APOBEC3G	5.29e-05	4	104	2	36480186
Pubmed	APOBEC3 proteins can copackage and comutate HIV-1 genomes.	APOBEC3D APOBEC3G	5.29e-05	4	104	2	27439715
Pubmed	CEM-T4 cells do not lack an APOBEC3G cofactor.	APOBEC3D APOBEC3G	5.29e-05	4	104	2	19649317
Pubmed	APOBEC3 proteins expressed in mammary epithelial cells are packaged into retroviruses and can restrict transmission of milk-borne virions.	APOBEC3D APOBEC3G	5.29e-05	4	104	2	21147467
Pubmed	Structural Features of Antiviral APOBEC3 Proteins are Linked to Their Functional Activities.	APOBEC3D APOBEC3G	5.29e-05	4	104	2	22203821
Pubmed	Restriction of foamy viruses by APOBEC cytidine deaminases.	APOBEC3D APOBEC3G	5.29e-05	4	104	2	16378963
Pubmed	Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G.	APOBEC3D APOBEC3G	5.29e-05	4	104	2	15269786
Pubmed	APOBEC3G cytidine deaminase inhibits retrotransposition of endogenous retroviruses.	APOBEC3D APOBEC3G	5.29e-05	4	104	2	15674295
Pubmed	Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway.	PIWIL4 MOV10L1	5.29e-05	4	104	2	20534472
Pubmed	APOBEC3 enzymes restrict marginal zone B cells.	APOBEC3D APOBEC3G	5.29e-05	4	104	2	25501566
Pubmed	Vaccinia virus replication is not affected by APOBEC3 family members.	APOBEC3D APOBEC3G	5.29e-05	4	104	2	17052331
Pubmed	APOBEC3 inhibits mouse mammary tumour virus replication in vivo.	APOBEC3D APOBEC3G	5.29e-05	4	104	2	17259974
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	EP400 MARS1 USP9X IGF2R MDN1 SACS UTP4 PLEC LAS1L MAP4K4 SNRNP200 XRCC6	5.73e-05	1024	104	12	24711643
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	CUL1 NRG1 WDR5 MDN1 XPO6 PLEC LAS1L SNRNP200 XRCC6	6.49e-05	582	104	9	20467437
Pubmed	USP45 and Spindly are part of the same complex implicated in cell migration.	CUL1 USP9X CCAR1 PLEC SNRNP200 XRCC6	7.80e-05	235	104	6	30258100
Pubmed	Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer.	PKD1 FGFR2 MAP4K4	8.06e-05	28	104	3	24462114
Pubmed	Phosphorylation directly regulates the intrinsic DNA cytidine deaminase activity of activation-induced deaminase and APOBEC3G protein.	APOBEC3D APOBEC3G	8.80e-05	5	104	2	21659520
Pubmed	Functional adrenergic receptor polymorphisms and idiopathic orthostatic intolerance.	ADRA2C ADRB1	8.80e-05	5	104	2	15719258
Pubmed	AID and APOBECs span the gap between innate and adaptive immunity.	APOBEC3D APOBEC3G	8.80e-05	5	104	2	25352838
Pubmed	The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements.	APOBEC3D APOBEC3G	8.80e-05	5	104	2	18304004
Pubmed	Host restriction of HIV-1 by APOBEC3 and viral evasion through Vif.	APOBEC3D APOBEC3G	8.80e-05	5	104	2	20012521
Pubmed	APOBEC3 inhibits DEAD-END function to regulate microRNA activity.	APOBEC3D APOBEC3G	8.80e-05	5	104	2	23890083
Pubmed	A computational analysis of the structural determinants of APOBEC3's catalytic activity and vulnerability to HIV-1 Vif.	APOBEC3D APOBEC3G	8.80e-05	5	104	2	25461536
Pubmed	Suppression of APOBEC3-mediated restriction of HIV-1 by Vif.	APOBEC3D APOBEC3G	8.80e-05	5	104	2	25206352
Pubmed	Interplay between HDAC3 and WDR5 is essential for hypoxia-induced epithelial-mesenchymal transition.	WDR5 HDAC3	8.80e-05	5	104	2	21884981
Pubmed	Polycystin channels and kidney disease.	PKDREJ PKD1	8.80e-05	5	104	2	11698076
Pubmed	HIV-1 Vif, APOBEC, and intrinsic immunity.	APOBEC3D APOBEC3G	8.80e-05	5	104	2	18577210
Pubmed	Different modes of retrovirus restriction by human APOBEC3A and APOBEC3G in vivo.	APOBEC3D APOBEC3G	8.80e-05	5	104	2	24851906
Pubmed	WDR5 facilitates EMT and metastasis of CCA by increasing HIF-1α accumulation in Myc-dependent and independent pathways.	WDR5 HDAC3	8.80e-05	5	104	2	33601056
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	EP400 DYNC2H1 SMC6 PIWIL4 WDR5 ADRA2C ROS1 EML1 SNRNP200 XRCC6	9.03e-05	754	104	10	35906200
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	MYADM RCCD1 MARS1 AHCTF1 SMC6 COL18A1 IGF2R VILL LTN1 PLEC UMAD1 LRRC71	9.81e-05	1084	104	12	11544199
Pubmed	Systematic identification of factors for provirus silencing in embryonic stem cells.	USP9X WDR5 MDN1 LAS1L SNRNP200	9.99e-05	153	104	5	26365490
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	EP400 CFAP43 EML3 IGF2R MDN1 XPO6 PKD1 LRP5 FGFR2 PLEC SYVN1 DHX34	1.17e-04	1105	104	12	35748872
Pubmed	Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling.	IGF2R LRP5 FGFR2	1.21e-04	32	104	3	34193412
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	CUL1 NRG1 MARS1 USP9X MDN1 CCAR1 MAP4K4 KDM4B	1.28e-04	497	104	8	36774506
Pubmed	Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.	MARS1 USP9X WDR5 HDAC3 SNRNP200 XRCC6	1.30e-04	258	104	6	21081666
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	CUL1 MARS1 USP9X MDN1 CCAR1 PLEC LAS1L SNRNP200 XRCC6	1.30e-04	638	104	9	33239621
Pubmed	Relation of beta(2)-adrenoceptor haplotype to risk of death and heart transplantation in patients with heart failure.	ADRA2C ADRB1	1.32e-04	6	104	2	17223428
Pubmed	Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein.	HDAC3 KDM4B	1.32e-04	6	104	2	15927959
Pubmed	Vif proteins of human and simian immunodeficiency viruses require cellular CBFβ to degrade APOBEC3 restriction factors.	APOBEC3D APOBEC3G	1.32e-04	6	104	2	22205746
Pubmed	A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing.	PIWIL4 MOV10L1	1.32e-04	6	104	2	22902560
Pubmed	Retroelements versus APOBEC3 family members: No great escape from the magnificent seven.	APOBEC3D APOBEC3G	1.32e-04	6	104	2	22912627
Pubmed	APOBEC3 versus Retroviruses, Immunity versus Invasion: Clash of the Titans.	APOBEC3D APOBEC3G	1.32e-04	6	104	2	22720156
Pubmed	Structure-guided analysis of the human APOBEC3-HIV restrictome.	APOBEC3D APOBEC3G	1.32e-04	6	104	2	24657093
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	CUL1 MARS1 SMC6 MDN1 LAS1L ZMYM5	1.41e-04	262	104	6	36880596
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	USP9X TBC1D7 KIAA0319 LRIG2 HDAC3 IGF2R MDN1 CCAR1 EML1 MAP4K4 XRCC6	1.48e-04	963	104	11	28671696
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	EP400 USP9X PEG10 WDR5 XRCC6	1.51e-04	167	104	5	20362541
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	EP400 MARS1 AHCTF1 WDR5 DCK COL18A1 MDN1 UTP4 CCAR1 PLEC LAS1L SNRNP200 XRCC6	1.56e-04	1318	104	13	30463901
Pubmed	High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.	NTF3 WDR5 CRHR2 HDAC3 IGF2R LRP5 FGFR2	1.58e-04	383	104	7	19453261
Pubmed	Myristoylated alanine-rich C-kinase substrate effector domain phosphorylation regulates the growth and radiation sensitization of glioblastoma.	WDR5 IGF2R XRCC6	1.59e-04	35	104	3	30942445
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	CUL1 RCCD1 MARS1 SMC6 IGF2R MDN1 CCAR1 PLEC SNRNP200 XRCC6	1.60e-04	809	104	10	32129710
Pubmed	APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons.	APOBEC3D APOBEC3G	1.84e-04	7	104	2	16527742
Cytoband	12p13	NTF3 TAS2R13 CD69	4.14e-04	64	103	3	12p13
Cytoband	Ensembl 112 genes in cytogenetic band chr22q13	APOBEC3D APOBEC3G PKDREJ MOV10L1 XRCC6	9.17e-04	330	103	5	chr22q13
Cytoband	13q12	SACS ZMYM5	1.33e-03	24	103	2	13q12
GeneFamily	Myosins, class III\|Deafness associated genes	MYO3A MYO3B	2.13e-05	2	84	2	1099
GeneFamily	WD repeat domain containing	PEX7 WDR5 CFAP43 EML3 UTP4 IFT80 EML1	2.17e-04	262	84	7	362
GeneFamily	Adrenoceptors	ADRA2C ADRB1	7.52e-04	9	84	2	169
GeneFamily	C-type lectin domain family	PLA2R1 CLEC4E CD69	1.35e-03	47	84	3	494
GeneFamily	Apolipoprotein B mRNA editing enzyme catalytic subunits	APOBEC3D APOBEC3G	1.37e-03	12	84	2	406
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NRG1 HTR4 PIWIL4 GCNT1 SLC22A24 KIAA0319	3.55e-06	177	103	6	7e799333307448c6a94d1f33dbc59c543336f45e
ToppCell	CF-Myeloid-Neutrophil\|CF / Disease state, Lineage and Cell class	TBC1D7 IL18RAP KIAA0319 XPO6 DHX34 MAP4K4	4.30e-06	183	103	6	da43827952e6fdee2ce94648c316182f272b321c
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3AP1 DCK SNX29 CD69 SYVN1 XRCC6	6.01e-06	194	103	6	11709704079f24a730476572dc2f01e9d2226e2c
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3AP1 DCK SNX29 CD69 SYVN1 XRCC6	6.01e-06	194	103	6	3a1f95639d5f239f001bd67d4213e8938e7f299d
ToppCell	severe-Myeloid-Neutrophils_4\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MYADM GRAMD1A IL18RAP IGF2R XPO6 MAP4K4	6.95e-06	199	103	6	50242666def13e5d4149c563ae000d6768f086f7
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial-Astrocyte\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	AHCTF1 LRIG2 PLA2R1 ZNF517 MAMDC2 FGFR2	7.15e-06	200	103	6	b9bd6c4381c92bfc1bfff9aa778a62a41d08f1ef
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Cbln1-Excitatory_Neuron.Slc17a7.Cbln1-Gpr88_(Medial_entorrhinal_cortex)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CRHR2 PPP1R3A CD69 GKN1	8.68e-06	56	103	4	a310f50724ada8da92257c54b18d9214d7415010
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Cbln1-Excitatory_Neuron.Slc17a7.Cbln1-Gpr88_(Medial_entorrhinal_cortex)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CRHR2 PPP1R3A CD69 GKN1	8.68e-06	56	103	4	4740900fffc892200f3e2480328eb43cb6d19f20
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c6-FGF23\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PIK3AP1 CLEC4E SLC13A1 CD69 MAP4K4	1.30e-05	130	103	5	793c42602dde22da0715a5304ea70d791fdd5354
ToppCell	P03-Epithelial-epithelial_progenitor_cell-epi_progenitor\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PPP1R3A PITPNM3 FGFR2 KLHDC7A EPCAM	2.68e-05	151	103	5	fce04bce66411c21cd5d4d41375f26f1f50f3348
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRAMD1A EML3 COL18A1 ADRA2C PITPNM3	3.23e-05	157	103	5	a426c54fd1545093d41426e9620862f71bd06f6b
ToppCell	COVID-19-APC-like-Monocytes\|COVID-19 / group, cell type (main and fine annotations)	PIWIL4 EML3 LAS1L TVP23A ZMYM5	3.33e-05	158	103	5	a0d94bd067424783863a48db20976d4c2043600c
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PIK3AP1 CLEC4E SLC13A1 CD69 MAP4K4	3.43e-05	159	103	5	6c0ef40f64d2e35eaae3d0002e3c1f22d1239736
ToppCell	droplet-Kidney-KIDNEY-1m-Lymphocytic-lymphocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XCR1 MYADM DCK PTPRO NEGR1	3.43e-05	159	103	5	3bab00f8fb7d9232538e50f83dd0fd70ddd16819
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PIK3AP1 CLEC4E SLC13A1 CD69 MAP4K4	3.43e-05	159	103	5	745a59c33b04620c5329bdd50e74a8e611f2dc55
ToppCell	facs-Kidney-nan-3m-Myeloid-macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3AP1 MYADM DCK ADRB1 PTPRO	4.33e-05	167	103	5	991a93e1075d562b7391f0689b2f62c1351d48d1
ToppCell	facs-Kidney-nan-3m-Myeloid\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3AP1 MYADM DCK ADRB1 PTPRO	4.33e-05	167	103	5	f22d1471c785b30d096ec5cdc68974e850ed7de0
ToppCell	facs-Kidney-nan-3m-Myeloid-macrophage\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3AP1 MYADM DCK ADRB1 PTPRO	4.33e-05	167	103	5	934905aeaafbc215ec8f6a7903498b0e258b9220
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NRG1 DYNC2H1 CFAP43 KIAA0319 ANKRD45	4.58e-05	169	103	5	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	control-Myeloid-Eosinophils\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CACNG8 CD69 HRH4 FGFR2 KLHDC7A	4.85e-05	171	103	5	82f736c33ed96c0865618e8f8eb82a5487126bdc
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NRG1 HTR4 PIWIL4 GCNT1 SLC22A24	4.85e-05	171	103	5	6a489a75eeab2a2d48d604682e93599c20a945fe
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-regulatory_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RCCD1 CACNG8 MYO3B CD69 IFT80	4.98e-05	172	103	5	10a1d1838492b8ce6dea08844353b51571432c56
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NRG1 HTR4 PIWIL4 GCNT1 SLC22A24	4.98e-05	172	103	5	92e76cbf4807704790f42cf2507e92f85cd3bc92
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-Regulatory_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RCCD1 CACNG8 MYO3B CD69 IFT80	4.98e-05	172	103	5	d824e46c8040b0bb9235f9b8a2b35386b303caa0
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NRG1 HTR4 PIWIL4 GCNT1 SLC22A24	5.12e-05	173	103	5	ee972d9cc68755926512fd3bbe1267098c67cd94
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	NPTX2 DCK KIAA0319 SACS PITPNM3	5.12e-05	173	103	5	20889aa85e36ad3bafdb91b91e43964493c949f9
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	NPTX2 DCK KIAA0319 SACS PITPNM3	5.12e-05	173	103	5	46e601b7938b1dd0aa3df7aa056c4bd07b1620c1
ToppCell	facs-Skin-nan-24m-Lymphocytic-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XCR1 GCNT1 SACS PTPRO CD69	5.26e-05	174	103	5	6863222bec844f40c0c80f5c82a8ff51d1a56d0a
ToppCell	facs-Skin-nan-24m-Lymphocytic\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XCR1 GCNT1 SACS PTPRO CD69	5.26e-05	174	103	5	5739c1b8d643ad360ef32049832d749c530ca603
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NRG1 CRHR2 KIAA0319 PLA2R1 ROS1	5.26e-05	174	103	5	ae363ce736fc8af439f3ad594d7bc2e344db80d4
ToppCell	facs-Skin-nan-24m-Lymphocytic-T_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XCR1 GCNT1 SACS PTPRO CD69	5.26e-05	174	103	5	d570eab215f8287362084e37f35672e20aa0f7a2
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NRG1 HTR4 PIWIL4 GCNT1 SLC22A24	5.26e-05	174	103	5	2947e5906b172d149412fa4e77476fce4ea695d2
ToppCell	facs-Skin-Anagen-3m-Lymphocytic-T_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3AP1 IL18RAP ADAMTS10 SACS CD69	5.71e-05	177	103	5	7853430fb0d1a18d835e8956777e0616c5d7d412
ToppCell	facs-Skin-Anagen-3m-Lymphocytic\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3AP1 IL18RAP ADAMTS10 SACS CD69	5.71e-05	177	103	5	395f005f019aabb18738d3a10a04c37f216deda3
ToppCell	facs-Skin-Anagen-3m-Lymphocytic-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3AP1 IL18RAP ADAMTS10 SACS CD69	5.71e-05	177	103	5	9a5bf67a801826d094f679dd2189b62296c9694f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PIK3AP1 NRG1 SLC22A24 MYO3A SLC13A1	6.02e-05	179	103	5	58ae5a97fe2a14e1c6fdeb886397eb06fdaf0428
ToppCell	droplet-Marrow-nan-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRG1 MYADM SMC6 PTPRO PLEC	6.51e-05	182	103	5	bc8d621be57f76d718d9b0f11e023b0f4dcb668d
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like\|lymph-node_spleen / Manually curated celltypes from each tissue	TMEM107 IL18RAP NEGR1 CD69 EPCAM	6.86e-05	184	103	5	d97471a4fe17cba6880ccf1a04cc00c741558124
ToppCell	droplet-Kidney-KIDNEY-1m-Lymphocytic-CD45____T_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRAMD1A FSD2 SACS PKD1 CD69	6.86e-05	184	103	5	2c8e9ddce3e60302965dcf9dee77c4fe33e4071d
ToppCell	mild-Myeloid-Neutrophils_1\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	AHCTF1 COL18A1 IGF2R XPO6 DHX34	6.86e-05	184	103	5	1a0e8b20b3ac8416d05c2d5934ab4ac80be4cce5
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	PEG10 CACNG8 ADRB1 NEGR1 EPCAM	7.98e-05	190	103	5	6e92c78799f34b31d098854503c796edb0dc7f80
ToppCell	control-Myeloid-Neutrophils_1\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	AHCTF1 COL18A1 IGF2R XPO6 DHX34	8.18e-05	191	103	5	db1b3cd07d7d190155b2d14e82e1d124975fbd0b
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3AP1 DCK CD69 SYVN1 XRCC6	8.18e-05	191	103	5	318323a12029a7992f16382cb0c186f5b2e1ca47
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3AP1 DCK CD69 SYVN1 XRCC6	8.18e-05	191	103	5	4aa29337f4d2528577bb90dc4abfb6eab93e120f
ToppCell	control-Myeloid-Neutrophils_3\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	IL18RAP CLEC4E IGF2R XPO6 MAP4K4	8.59e-05	193	103	5	56daf3c59a124dd068af5409113913d9ee81a454
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-B_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PIK3AP1 SMC6 SYVN1 MAP4K4 KDM4B	8.80e-05	194	103	5	ff661419b697aef51a53fdeac8d37d870d65f491
ToppCell	control-Myeloid-Neutrophils_3\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	IL18RAP CLEC4E IGF2R XPO6 MAP4K4	8.80e-05	194	103	5	2218e6677dc6781a6e4ef3a315f2298cc2cd9df2
ToppCell	mild-Myeloid-Neutrophils_3\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MYADM CLEC4E IGF2R XPO6 DHX34	9.01e-05	195	103	5	a1cfed0092debcc003eff6a62508556b7664d5e1
ToppCell	mild-Myeloid-Neutrophils_3\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CLEC4E IGF2R XPO6 DHX34 MAP4K4	9.23e-05	196	103	5	9c351306b6aae68ed47d4cb1911957bf67f9e1ae
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sncg-Sncg_Gpr50\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PIWIL4 SLC13A1 MOV10L1 EPCAM	9.62e-05	103	103	4	d8965b338b90ddc0686ea0d94e9a330128566c39
ToppCell	(02)_Cycling_Basal_(regeneration)-(4)_1wkpi\|(02)_Cycling_Basal_(regeneration) / shred by cell type and Timepoint	NTF3 CRHR2 CLEC4E GKN1	9.62e-05	103	103	4	942cc6f9699f777638e59aee40a402a16fdbb2e7
ToppCell	facs-Tongue-nan-3m-Epithelial-basal_cell_of_epidermis\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYADM USP9X COL18A1 FGFR2 PLEC	9.69e-05	198	103	5	22559b161e67b49fe8028bfaf861e069063599f5
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Mesenchymal-Cilia-bearing_cell\|10w / Sample Type, Dataset, Time_group, and Cell type.	NTF3 GCNT1 EML3 COL18A1 FGFR2	9.92e-05	199	103	5	2d8ab4aee300c7c4baf662940ce855da2b6d2cae
ToppCell	LPS_anti-TNF-Hematopoietic_Myeloid-Granulocytic_cells-Neutrophils\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PIK3AP1 IL18RAP CLEC4E CD69 MAP4K4	9.92e-05	199	103	5	76aab03a51681f0ce3369887cf71a884b0998ec5
ToppCell	LPS_anti-TNF-Hematopoietic_Myeloid-Granulocytic_cells\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PIK3AP1 IL18RAP CLEC4E CD69 MAP4K4	9.92e-05	199	103	5	7227e6be56e9f333ee143e1418d22de32a4ca66a
ToppCell	Control-Control-Myeloid-Neutrophil\|Control / Disease, condition lineage and cell class	AHCTF1 PLA2R1 CLEC4E IGF2R XPO6	1.02e-04	200	103	5	95c41f147a1594d49e73cb56d86d301c3115ce20
ToppCell	LPS_only-Hematopoietic_Myeloid-Granulocytic_cells-Neutrophils\|LPS_only / Treatment groups by lineage, cell group, cell type	PIK3AP1 IL18RAP CLEC4E CD69 MAP4K4	1.02e-04	200	103	5	3504aeba7b30cac9c428ba3871c072e2202752b4
ToppCell	severe-Myeloid-Neutrophils_4\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MYADM GRAMD1A IL18RAP IGF2R XPO6	1.02e-04	200	103	5	b665f36dcf3c9d3981ee96f2973512f751612542
ToppCell	Parenchymal-10x3prime_v2-Stromal-Peri/Epineurial_\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	PEX7 PLA2R1 NEGR1 PITPNM3 FITM2	1.02e-04	200	103	5	5ad3ea1cf1fcd4100966c5517bc7ed0a1af54317
ToppCell	Neuronal-Excitatory-eB(RORB)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	NRG1 HTR4 PIWIL4 GCNT1 SLC22A24	1.02e-04	200	103	5	51265e30f1138fd79733001d0db759f3dab0aaeb
Disease	asphyxiating thoracic dystrophy 3 (implicated_via_orthology)	DYNC2H1 IFT80	1.14e-05	2	100	2	DOID:0110087 (implicated_via_orthology)
Disease	autosomal dominant polycystic kidney disease (is_implicated_in)	PKD1 LRP5	6.79e-05	4	100	2	DOID:898 (is_implicated_in)
Disease	Jeune thoracic dystrophy	DYNC2H1 IFT80	6.79e-05	4	100	2	cv:C0265275
Disease	Short rib-polydactyly syndrome, Verma-Naumoff type	DYNC2H1 IFT80	1.13e-04	5	100	2	C0432197
Disease	polycystic liver disease (implicated_via_orthology)	PKD1 LRP5	2.36e-04	7	100	2	DOID:0050770 (implicated_via_orthology)
Disease	Mood Disorders	HTR4 NTF3 CRHR2 ADRA2C ADRB1	2.74e-04	168	100	5	C0525045
Disease	Ventricular Dysfunction	ADRB1 IGF2R	3.14e-04	8	100	2	C0242973
Disease	Endomyocardial Fibrosis	ADRB1 IGF2R	4.03e-04	9	100	2	C0553980
Disease	estrogen measurement	SLC22A24 SLC22A9	5.03e-04	10	100	2	EFO_0011007
Disease	Jeune thoracic dystrophy	DYNC2H1 IFT80	6.13e-04	11	100	2	C0265275
Disease	Polydactyly	DYNC2H1 USP9X FGFR2 IFT80	6.87e-04	117	100	4	C0152427
Disease	Familial thoracic aortic aneurysm and aortic dissection	ADAMTS10 COL18A1 PKD1	7.82e-04	53	100	3	C4707243
Disease	autosomal dominant polycystic kidney disease (implicated_via_orthology)	PKD1 LRP5	1.01e-03	14	100	2	DOID:898 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	NRG1 RCCD1 DYNC2H1 SMC6 PKDREJ PPP1R3A SLC22A9 TAS2R13 FGFR2 KLHDC7A GKN1	1.04e-03	1074	100	11	C0006142
Disease	lipid metabolism disorder (implicated_via_orthology)	FADS2B FITM2	1.16e-03	15	100	2	DOID:3146 (implicated_via_orthology)
Disease	lymphocyte count	PIK3AP1 HTR4 SLC38A9 TBC1D7 FIS1 IL18RAP ADRB1 XPO6 CD69 KYAT3 PLEC GKN1 KDM4B	1.34e-03	1464	100	13	EFO_0004587
Disease	phosphoglyceric acid measurement	NTF3 TVP23A	1.50e-03	17	100	2	EFO_0010523
Disease	Anorexia	HTR4 CRHR2	1.68e-03	18	100	2	C0003123
Disease	Mental Depression	NRG1 HTR4 CRHR2 ADRB1 FGFR2	1.76e-03	254	100	5	C0011570
Disease	squamous cell carcinoma (is_marker_for)	FGFR2 XRCC6	1.87e-03	19	100	2	DOID:1749 (is_marker_for)
Disease	lymphocyte percentage of leukocytes	PIK3AP1 HTR4 PEX7 IL18RAP FCRLB CD69 GKN1 KDM4B	1.93e-03	665	100	8	EFO_0007993
Disease	ST2 protein measurement	IL18RAP MAP4K4	2.29e-03	21	100	2	EFO_0010599
Disease	Disproportionate short stature	DYNC2H1 FGFR2 IFT80	2.30e-03	77	100	3	C0878659
Disease	Lung diseases	CRHR2 CLEC4E IGF2R	2.39e-03	78	100	3	C0024115
Disease	small cell lung carcinoma	DYNC2H1 PIWIL4 UMAD1	2.57e-03	80	100	3	EFO_0000702
Disease	Ovarian Serous Adenocarcinoma	MYO3A FGFR2	2.75e-03	23	100	2	C1335177
Disease	Depressive disorder	NRG1 HTR4 CRHR2 ADRB1 FGFR2	3.07e-03	289	100	5	C0011581

Protein segments in the cluster

Peptide	Gene	Start	Entry
SRFWYDFTLENSVLC	UMAD1	121	C9J7I0
YGSFFCELWTSVDVL	ADRB1	126	P08588
WDLVSDVVNSCSRIY	EP400	2401	Q96L91
TEITCSERVRTYWII	EPCAM	131	P16422
ILCIRDVYTLETFAW	CFAP43	661	Q8NDM7
NLTIFTARLCYFWDT	APOBEC3D	311	Q96AK3
LTGIDLSVCTQWYRF	CCAR1	531	Q8IX12
LDLDQDYRVTCFTSW	APOBEC3G	271	Q9HC16
DETWYILSSCIGSFF	ADRA2C	206	P18825
ARYSQTECVEFLDWA	ANKRD45	151	Q5TZF3
EEWCQYLQTLFLSSR	PIK3AP1	21	Q6ZUJ8
ICFYSNIFRWETTIS	GRAMD1A	131	Q96CP6
FVWSSCSRDYITSFL	ADAMTS10	431	Q9H324
LACTDTWVYESTVFL	OR2L2	186	Q8NH16
ICRVSASWSYTAFVT	RCCD1	41	A6NED2
TCQARSSYLVDEVLW	KCNJ9	286	Q92806
RCETSSEYSSLRFKW	NRG1	56	Q02297
EEWSCLRLVYQITTS	MAMDC2	76	Q7Z304
LWEAVLYTLTTIEDC	LTN1	316	O94822
CYFISTVKRSWTSAQ	CD69	96	Q07108
ACTASRTVDSETWYF	FGFR2	106	P21802
DYRSDLWSCGITAIE	MAP4K4	211	O95819
RTALSEDRWSSYCLS	PASK	61	Q96RG2
LWTYSTRSEEEFVLF	IL18RAP	31	O95256
LSLDRAFSEACWEVY	MDN1	2381	Q9NU22
VVVESSQSCYVWRAL	MOV10L1	226	Q9BXT6
ADVLFSCWYLVLTLS	NEGR1	326	Q7Z3B1
IDIYSRTLFWTCEAT	LRP5	1031	O75197
SKSTQFEYAWCLVRS	FIS1	31	Q9Y3D6
SVLASCSYDFTVRFW	PEX7	256	O00628
LTESYCETWRTEAPS	COL18A1	1701	P39060
EVWCRCITTIFNYFV	CRHR2	181	Q13324
ITWSTRSIVFDSEYC	PEG10	456	Q86TG7
CAESTNFATLRWIDY	KDM4B	286	O94953
VLETDFAELCTRWGY	LRRC71	61	Q8N4P6
LSRAEWDQVTVYLFC	LAS1L	46	Q9Y4W2
IACVAYATEVAWTRA	MYADM	146	Q96S97
RGEYSVCDSESLWVT	NTF3	146	P20783
SWLTSAYFTGFIVCL	GPR52	196	Q9Y2T5
RLSCAASWFTFSIYE	IGHV8-51-1	36	P0DTE2
CWTYETSLLVEEAIS	HDAC3	306	O15379
EWTTYYEIAATVSLT	PTPRO	576	Q16827
EFCIRYETSVGTFWS	PPP1R3A	206	Q16821
VCFSLQDITWVSSFY	FADS2B	331	A8MWK0
SIFSALVVAWYSSAC	POMT1	696	Q9Y6A1
LYQTLCFEDAALWRT	DYNC2H1	3636	Q8NCM8
TDYWLYTRALICNTT	CACNG8	41	Q8WXS5
YTTSVLWIVDISFCG	GKN1	166	Q9NS71
LVSCVGWTTAEELYS	IFT80	16	Q9P2H3
TAIWYICTSIFSNIE	FITM2	101	Q8N6M3
IYEIYSLALVTWRDC	CUL1	156	Q13616
FLVAWTVTEITRYSF	HACD1	171	B0YJ81
WIYGEVFCLVRTSLD	HTR4	86	Q13639
SASTRLWYECATYRT	KLHDC7A	696	Q5VTJ3
RWSFTFQTYACLSRI	DCK	91	P27707
SYFALWSLESVVSRT	AHCTF1	426	Q8WYP5
ETTRDIEWATYTCTL	EML1	711	O00423
YESRDREWATYTCVL	EML3	766	Q32P44
ELESYWCEAATATRS	FCRLB	261	Q6BAA4
VFVASRLESVVYASW	GCNT1	176	Q02742
TDLYSDCLRTFWTCP	DHX34	1056	Q14147
CVDGWVYDRSIFTST	SLC22A12	116	Q96S37
ECAYTLFVVATFWLT	SLC13A1	36	Q9BZW2
SCDWVRLEQVYFSEL	SACS	566	Q9NZJ4
FSLDTTSWEYPDVCR	SLC38A9	176	Q8NBW4
TLCISDEVYEWLVYS	KYAT3	241	Q6YP21
SLEAGSDVRYSWVLC	PKD1	1571	P98161
ICVFWLTTDYLLCTA	HRH4	86	Q9H3N8
SRAKLWCSTTADYDR	IGF2R	1921	P11717
YASFFLCVLISWISE	TAS2R13	241	Q9NYV9
CSVELRTTAYNIWAV	TAS2R45	76	P59539
SWYAVTETCLAFTVF	SYVN1	81	Q86TM6
TAITTCEALTEWEYL	USP9X	1531	Q93008
CGSWIAYSTVSRFFL	UTP4	401	Q969X6
LADRCRLSTFYEDWS	SNX29	136	Q8TEQ0
CVDGWVYDRSSFLST	SLC22A24	116	Q8N4F4
VYDRSSFLSTIVTEW	SLC22A24	121	Q8N4F4
CVDGWVYDRISFSST	SLC22A9	116	Q8IVM8
VYDRISFSSTIVTEW	SLC22A9	121	Q8IVM8
LEAEFSISLYLACWS	PKDREJ	531	Q9NTG1
CVYVAWFLVFATSSI	PKDREJ	1576	Q9NTG1
TGSSVRVCWSLYSDD	FSD2	386	A1L4K1
RVCWSLYSDDTVESY	FSD2	391	A1L4K1
TWLILCSDRTEYVAE	PIWIL4	486	Q7Z3Z4
EDSVDCYWITRRFVN	TBC1D7	146	Q9P0N9
ELYAFTICLWLRSSA	NPTX2	246	P47972
LSLYECDSTLVSLRW	PLA2R1	101	Q13018
CYFFSTDTISWALSL	CLEC4E	91	Q9ULY5
LSSGCDYSELTWYLT	XCR1	171	P46094
YSLSEVLWVCANLFS	XRCC6	141	P12956
LSFFQCRWDDSVTYI	MRPL38	316	Q96DV4
ALSFFIFERWECTTY	TMEM107	96	Q6UX40
ERSFSTVCFILSLWS	SMC6	991	Q96SB8
WTFSAERVISAVCYT	ROS1	1176	P08922
RTVTVWELISSEYFT	PLEC	3386	Q15149
ASYWESTDVVAFILR	PITPNM3	576	Q9BZ71
SDIFLLVTASVCYLW	VILL	536	O15195
FEDVAVYFTRIEWSC	ZNF517	16	Q6ZMY9
YFIRVVSDRWLSCET	SNRNP200	1266	O75643
RSWLLYSTSKDSVFC	ZMYM5	576	Q9UJ78
FRVSAIVTYVSCDWF	TVP23A	41	A6NH52
SCLDIWTLFLDYLTS	XPO6	416	Q96QU8
STSAICRYFFLLSGW	MARS1	61	P56192
IVSSSYDGLCRIWDT	WDR5	186	P61964
VYWTERFLEDTTLTI	THEG	171	Q9P2T0
NCEWSIFYVTVLAFT	KIAA0319	951	Q5VV43
AWEFCQRLSELDLSY	LRIG2	306	O94898
TYDARCDTWSLGITA	MYO3A	206	Q8NEV4
SSYDARCDVWSLGIT	MYO3B	211	Q8WXR4