Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	QRFPR OR5B3 OR5M9 GPR50 OR7C2 OR5B2 OR11H4 OR9I1 OR6C70 OR5B17 OR1E2 OR2T1 OR2S2 OR5M3 NMUR2 GRM4 GRM7 OR7G3 GRM8 FZD2 OR51B2 GPR148 HCRTR1	3.32e-18	884	51	23	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	QRFPR OR5B3 OR5M9 GPR50 OR7C2 OR5B2 OR11H4 OR9I1 OR6C70 OR5B17 OR1E2 OR2T1 OR2S2 OR5M3 NMUR2 CHRNA10 GRM4 GRM7 OR7G3 GRM8 FZD2 OR51B2 GPR148 HCRTR1	2.80e-15	1353	51	24	GO:0004888
GeneOntologyMolecularFunction	olfactory receptor activity	OR5B3 OR5M9 OR7C2 OR5B2 OR11H4 OR9I1 OR6C70 OR5B17 OR1E2 OR2T1 OR2S2 OR5M3 OR7G3 OR51B2 GPR148	1.27e-13	431	51	15	GO:0004984
GeneOntologyMolecularFunction	odorant binding	OR5B3 OR5M9 OR5B2 OR9I1 OR5B17 OR5M3 GPR148	3.27e-08	127	51	7	GO:0005549
GeneOntologyMolecularFunction	group III metabotropic glutamate receptor activity	GRM4 GRM7 GRM8	6.27e-08	4	51	3	GO:0001642
GeneOntologyMolecularFunction	G protein-coupled glutamate receptor activity	GRM4 GRM7 GRM8	1.30e-06	9	51	3	GO:0098988
GeneOntologyMolecularFunction	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	GRM4 GRM7 GRM8	1.30e-06	9	51	3	GO:0001640
GeneOntologyMolecularFunction	glutamate receptor activity	GRM4 GRM7 GRM8	4.40e-05	27	51	3	GO:0008066
GeneOntologyMolecularFunction	glutamate binding	GAD2 GRM7	5.71e-04	14	51	2	GO:0016595
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	QRFPR OR5B3 OR5M9 GPR50 OR7C2 OR5B2 OR11H4 OR9I1 OR6C70 OR5B17 OR1E2 OR2T1 OR2S2 OR5M3 NMUR2 GRM4 GRM7 OR7G3 GRM8 FZD2 OR51B2 GPR148 HCRTR1 FOXC1	2.70e-15	1395	51	24	GO:0007186
GeneOntologyBiologicalProcess	sensory perception of smell	OR5B3 OR5M9 OR7C2 OR5B2 OR11H4 OR9I1 OR6C70 OR5B17 OR1E2 OR2T1 OR2S2 OR5M3 OR7G3 FZD2 OR51B2 GPR148	1.20e-14	465	51	16	GO:0007608
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR5B3 OR5M9 OR7C2 OR5B2 OR11H4 OR9I1 OR6C70 OR5B17 OR1E2 OR2T1 OR2S2 OR5M3 CHRNA10 OR7G3 GRM8 OR51B2 GPR148	2.19e-14	582	51	17	GO:0050906
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR5B3 OR5M9 OR7C2 OR5B2 OR11H4 OR9I1 OR6C70 OR5B17 OR1E2 OR2T1 OR2S2 OR5M3 OR7G3 OR51B2 GPR148	8.24e-14	432	51	15	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR5B3 OR5M9 OR7C2 OR5B2 OR11H4 OR9I1 OR6C70 OR5B17 OR1E2 OR2T1 OR2S2 OR5M3 OR7G3 FZD2 OR51B2 GPR148	1.47e-13	547	51	16	GO:0007606
GeneOntologyBiologicalProcess	sensory perception	OR5B3 OR5M9 OR7C2 OR5B2 OR11H4 OR9I1 OR6C70 OR5B17 OR1E2 OR2T1 OR2S2 OR5M3 NMUR2 CHRNA10 GRM7 OR7G3 GRM8 FZD2 OR51B2 GPR148	2.89e-13	1072	51	20	GO:0007600
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR5B3 OR5M9 OR7C2 OR5B2 OR11H4 OR9I1 OR6C70 OR5B17 OR1E2 OR2T1 OR2S2 OR5M3 OR7G3 OR51B2 GPR148	4.40e-13	485	51	15	GO:0050907
GeneOntologyBiologicalProcess	detection of stimulus	OR5B3 OR5M9 OR7C2 OR5B2 OR11H4 OR9I1 OR6C70 OR5B17 OR1E2 OR2T1 OR2S2 OR5M3 CHRNA10 OR7G3 GRM8 OR51B2 GPR148	7.17e-13	722	51	17	GO:0051606
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR5B3 OR5M9 OR7C2 OR5B2 OR11H4 OR9I1 OR6C70 OR5B17 OR1E2 OR2T1 OR2S2 OR5M3 OR7G3 OR51B2 GPR148	1.34e-12	524	51	15	GO:0009593
GeneOntologyBiologicalProcess	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	GRM4 GRM7 GRM8	1.18e-06	9	51	3	GO:0007196
GeneOntologyBiologicalProcess	G protein-coupled glutamate receptor signaling pathway	GRM4 GRM7 GRM8	7.80e-06	16	51	3	GO:0007216
GeneOntologyBiologicalProcess	anterograde trans-synaptic signaling	SLC6A1 GAD2 AFDN DMD CHRNA10 GRM4 GRM7 GRM8 HCRTR1	4.12e-04	931	51	9	GO:0098916
GeneOntologyBiologicalProcess	chemical synaptic transmission	SLC6A1 GAD2 AFDN DMD CHRNA10 GRM4 GRM7 GRM8 HCRTR1	4.12e-04	931	51	9	GO:0007268
GeneOntologyBiologicalProcess	glutamate receptor signaling pathway	GRM4 GRM7 GRM8	4.20e-04	59	51	3	GO:0007215
GeneOntologyBiologicalProcess	trans-synaptic signaling	SLC6A1 GAD2 AFDN DMD CHRNA10 GRM4 GRM7 GRM8 HCRTR1	4.39e-04	939	51	9	GO:0099537
GeneOntologyCellularComponent	presynaptic active zone membrane	AFDN GRM4 GRM7 GRM8	3.92e-05	78	51	4	GO:0048787
GeneOntologyCellularComponent	GABA-ergic synapse	SLC6A1 GAD2 DMD GRM7 GRM8	4.91e-05	164	51	5	GO:0098982
GeneOntologyCellularComponent	presynaptic membrane	SLC6A1 GAD2 AFDN GRM4 GRM7 GRM8	5.60e-05	277	51	6	GO:0042734
GeneOntologyCellularComponent	synaptic membrane	SLC6A1 GAD2 AFDN DMD CHRNA10 GRM4 GRM7 GRM8	7.72e-05	583	51	8	GO:0097060
GeneOntologyCellularComponent	presynaptic active zone	AFDN GRM4 GRM7 GRM8	3.88e-04	141	51	4	GO:0048786
MousePheno	abnormal prepulse inhibition	SLC6A1 GAD2 BRD4 AFDN SLC44A4 GRM4 GRM8 CYFIP2	2.24e-05	542	32	8	MP:0003088
MousePheno	increased skeletal muscle weight	INHBA DMD	7.57e-05	6	32	2	MP:0010238
Domain	GPCR_Rhodpsn_7TM	QRFPR OR5B3 OR5M9 GPR50 OR7C2 OR5B2 OR11H4 OR9I1 OR6C70 OR5B17 OR1E2 OR2T1 OR2S2 OR5M3 NMUR2 OR7G3 OR51B2 GPR148 HCRTR1	4.47e-15	670	51	19	IPR017452
Domain	7tm_1	QRFPR OR5B3 OR5M9 GPR50 OR7C2 OR5B2 OR11H4 OR9I1 OR6C70 OR5B17 OR1E2 OR2T1 OR2S2 OR5M3 NMUR2 OR7G3 OR51B2 GPR148 HCRTR1	5.39e-15	677	51	19	PF00001
Domain	G_PROTEIN_RECEP_F1_1	QRFPR OR5B3 OR5M9 GPR50 OR7C2 OR5B2 OR11H4 OR9I1 OR6C70 OR5B17 OR1E2 OR2T1 OR2S2 OR5M3 NMUR2 OR7G3 OR51B2 GPR148 HCRTR1	6.67e-15	685	51	19	PS00237
Domain	G_PROTEIN_RECEP_F1_2	QRFPR OR5B3 OR5M9 GPR50 OR7C2 OR5B2 OR11H4 OR9I1 OR6C70 OR5B17 OR1E2 OR2T1 OR2S2 OR5M3 NMUR2 OR7G3 OR51B2 GPR148 HCRTR1	7.81e-15	691	51	19	PS50262
Domain	GPCR_Rhodpsn	QRFPR OR5B3 OR5M9 GPR50 OR7C2 OR5B2 OR11H4 OR9I1 OR6C70 OR5B17 OR1E2 OR2T1 OR2S2 OR5M3 NMUR2 OR7G3 OR51B2 GPR148 HCRTR1	8.02e-15	692	51	19	IPR000276
Domain	Olfact_rcpt	OR5B3 OR5M9 OR7C2 OR5B2 OR11H4 OR9I1 OR6C70 OR5B17 OR1E2 OR2T1 OR2S2 OR5M3 OR7G3 OR51B2	1.69e-12	393	51	14	IPR000725
Domain	GPCR_3_mtglu_rcpt	GRM4 GRM7 GRM8	1.06e-06	8	51	3	IPR000162
Domain	NCD3G	GRM4 GRM7 GRM8	5.38e-06	13	51	3	PF07562
Domain	GPCR_3_9-Cys_dom	GRM4 GRM7 GRM8	5.38e-06	13	51	3	IPR011500
Domain	GPCR_3_CS	GRM4 GRM7 GRM8	6.84e-06	14	51	3	IPR017979
Domain	GPCR_3	GRM4 GRM7 GRM8	2.46e-05	21	51	3	IPR000337
Domain	G_PROTEIN_RECEP_F3_4	GRM4 GRM7 GRM8	2.85e-05	22	51	3	PS50259
Domain	7tm_3	GRM4 GRM7 GRM8	2.85e-05	22	51	3	PF00003
Domain	GPCR_3_C	GRM4 GRM7 GRM8	2.85e-05	22	51	3	IPR017978
Domain	G_PROTEIN_RECEP_F3_2	GRM4 GRM7 GRM8	2.85e-05	22	51	3	PS00980
Domain	G_PROTEIN_RECEP_F3_3	GRM4 GRM7 GRM8	2.85e-05	22	51	3	PS00981
Domain	G_PROTEIN_RECEP_F3_1	GRM4 GRM7 GRM8	2.85e-05	22	51	3	PS00979
Domain	ANF_receptor	GRM4 GRM7 GRM8	1.40e-04	37	51	3	PF01094
Domain	ANF_lig-bd_rcpt	GRM4 GRM7 GRM8	1.40e-04	37	51	3	IPR001828
Domain	Peripla_BP_I	GRM4 GRM7 GRM8	1.64e-04	39	51	3	IPR028082
Domain	7TM_GPCR_Srsx	GPR50 NMUR2 HCRTR1	3.55e-03	112	51	3	SM01381
Domain	TF_fork_head_CS_2	FOXI3 FOXC1	7.01e-03	46	51	2	IPR030456
Domain	WW	APBB3 DMD	7.31e-03	47	51	2	PF00397
Domain	TF_fork_head_CS_1	FOXI3 FOXC1	7.31e-03	47	51	2	IPR018122
Domain	WW	APBB3 DMD	7.61e-03	48	51	2	SM00456
Domain	FORK_HEAD_3	FOXI3 FOXC1	7.92e-03	49	51	2	PS50039
Domain	FH	FOXI3 FOXC1	7.92e-03	49	51	2	SM00339
Domain	FORK_HEAD_1	FOXI3 FOXC1	7.92e-03	49	51	2	PS00657
Domain	FORK_HEAD_2	FOXI3 FOXC1	7.92e-03	49	51	2	PS00658
Domain	Forkhead	FOXI3 FOXC1	7.92e-03	49	51	2	PF00250
Domain	Fork_head_dom	FOXI3 FOXC1	7.92e-03	49	51	2	IPR001766
Domain	WW_DOMAIN_2	APBB3 DMD	8.56e-03	51	51	2	PS50020
Domain	WW_DOMAIN_1	APBB3 DMD	8.56e-03	51	51	2	PS01159
Domain	WW_dom	APBB3 DMD	8.88e-03	52	51	2	IPR001202
Domain	CH	CFAP47 DMD	1.57e-02	70	51	2	PF00307
Domain	-	CFAP47 DMD	1.61e-02	71	51	2	1.10.418.10
Domain	CH	CFAP47 DMD	1.70e-02	73	51	2	PS50021
Pathway	REACTOME_SENSORY_PERCEPTION	OR5B3 OR5M9 RDH16 OR7C2 OR5B2 OR11H4 OR9I1 OR6C70 OR5B17 OR1E2 OR2T1 OR2S2 OR5M3 CHRNA10 GRM4 OR7G3 OR51B2	9.55e-13	636	42	17	M41834
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR5B3 OR5M9 OR7C2 OR5B2 OR11H4 OR9I1 OR6C70 OR5B17 OR1E2 OR2T1 OR2S2 OR5M3 OR7G3 OR51B2	7.86e-12	417	42	14	M4072
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR5B3 OR5M9 OR7C2 OR11H4 OR9I1 OR6C70 OR5B17 OR1E2 OR2T1 OR2S2 OR5M3 OR7G3 OR51B2	5.45e-11	389	42	13	M14091
Pathway	WP_GPCRS_NONODORANT	QRFPR GPR50 NMUR2 GRM4 GRM7 GRM8 FZD2 HCRTR1	9.80e-07	266	42	8	MM15843
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	GPR50 OR7C2 OR1E2 OR2T1 OR2S2 NMUR2 HCRTR1	1.04e-05	260	42	7	M39397
Pathway	WP_GPCRS_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE	GRM4 GRM7 GRM8	1.09e-05	15	42	3	M39442
Pathway	WP_GPCRS_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE	GRM4 GRM7 GRM8	1.09e-05	15	42	3	MM15845
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	GPR50 NMUR2 CHRNA10 GRM4 GRM7 GRM8 HCRTR1	1.40e-05	272	42	7	M13380
Pathway	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	GRM4 GRM7 GRM8	1.78e-04	37	42	3	MM15067
Pathway	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	GRM4 GRM7 GRM8	2.09e-04	39	42	3	M793
Pathway	REACTOME_OREXIN_AND_NEUROPEPTIDES_FF_AND_QRFP_BIND_TO_THEIR_RESPECTIVE_RECEPTORS	QRFPR HCRTR1	2.40e-04	8	42	2	M27291
Pathway	REACTOME_OREXIN_AND_NEUROPEPTIDES_FF_AND_QRFP_BIND_TO_THEIR_RESPECTIVE_RECEPTORS	QRFPR HCRTR1	2.40e-04	8	42	2	MM14995
Pathway	REACTOME_GPCR_LIGAND_BINDING	QRFPR NMUR2 GRM4 GRM7 GRM8 FZD2 HCRTR1	3.92e-04	463	42	7	M507
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR11H4 OR1E2 OR2T1	1.17e-03	70	42	3	MM14984
Pathway	REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION	SLC6A1 GAD2	1.43e-03	19	42	2	M927
Pathway	REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION	SLC6A1 GAD2	1.43e-03	19	42	2	MM15523
Pathway	REACTOME_GPCR_LIGAND_BINDING	QRFPR NMUR2 GRM4 GRM7 GRM8 HCRTR1	1.61e-03	430	42	6	MM15160
Pathway	REACTOME_SENSORY_PERCEPTION	RDH16 OR11H4 OR1E2 OR2T1	2.40e-03	190	42	4	MM15687
Pathway	WP_GPCRS_OTHER	OR1E2 OR2T1 FZD2	2.90e-03	96	42	3	MM15939
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR5B3 OR5M9 OR7C2 OR5B2 OR11H4 OR9I1 OR6C70 OR1E2 OR2T1 OR5M3 OR7G3 OR51B2	7.08e-14	340	51	12	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR5B3 OR5M9 OR7C2 OR5B2 OR11H4 OR9I1 OR6C70 OR1E2 OR2T1 OR5M3 OR7G3 OR51B2	7.08e-14	340	51	12	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR5B3 OR5M9 OR7C2 OR5B2 OR11H4 OR9I1 OR6C70 OR1E2 OR2T1 OR5M3 OR7G3 OR51B2	7.86e-14	343	51	12	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR5B3 OR5M9 OR7C2 OR5B2 OR11H4 OR9I1 OR6C70 OR1E2 OR2T1 OR5M3 OR7G3 OR51B2	8.71e-14	346	51	12	14611657
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR5M9 OR7C2 OR5B2 OR9I1 OR1E2 OR2T1 OR2S2 OR5M3 OR7G3 OR51B2	8.13e-13	219	51	10	12213199
Pubmed	Odorant and vomeronasal receptor genes in two mouse genome assemblies.	OR5M9 OR7C2 OR11H4 OR9I1 OR6C70 OR1E2 OR7G3	1.58e-11	74	51	7	15081110
Pubmed	The human olfactory receptor gene family.	OR5B3 OR5M9 OR7C2 OR5B2 OR11H4 OR9I1 OR5B17 OR1E2 OR2T1 OR2S2 OR5M3 OR7G3	1.63e-11	541	51	12	14983052
Pubmed	Association between the group III metabotropic glutamate receptor gene polymorphisms and attention-deficit/hyperactivity disorder and functional exploration of risk loci.	GRM4 GRM7 GRM8	2.97e-09	3	51	3	33068816
Pubmed	Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells.	GRM4 GRM7 GRM8	2.97e-09	3	51	3	9473604
Pubmed	Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.	SLC6A1 GAD2 GRM4 GRM7 GRM8	6.48e-09	45	51	5	25979088
Pubmed	Distribution of group-III metabotropic glutamate receptors in the retina.	GRM4 GRM7 GRM8	1.19e-08	4	51	3	17311335
Pubmed	Pias1 interaction and sumoylation of metabotropic glutamate receptor 8.	GRM4 GRM7 GRM8	5.92e-08	6	51	3	16144832
Pubmed	The G protein-coupled receptor repertoires of human and mouse.	QRFPR GRM4 GRM7 GPR148 HCRTR1	1.15e-07	79	51	5	12679517
Pubmed	Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.	GRM4 GRM7 GRM8	3.54e-07	10	51	3	9069281
Pubmed	The repertoire of olfactory C family G protein-coupled receptors in zebrafish: candidate chemosensory receptors for amino acids.	GRM4 GRM7 GRM8	3.54e-07	10	51	3	17156446
Pubmed	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	GAD2 CHRNA10 GRM4 GRM7 GRM8	8.56e-07	118	51	5	19156168
Pubmed	Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia.	GRM4 GRM7	2.11e-06	2	51	2	19351574
Pubmed	Characterisation of an mGlu8 receptor-selective agonist and antagonist in the lateral and medial perforant path inputs to the dentate gyrus.	GRM7 GRM8	2.11e-06	2	51	2	23220400
Pubmed	No association between metabotropic glutamate receptors 7 and 8 (mGlur7 and mGlur8) gene polymorphisms and withdrawal seizures and delirium tremens in alcohol-dependent individuals.	GRM7 GRM8	2.11e-06	2	51	2	11912074
Pubmed	Significant association of GRM7 and GRM8 genes with schizophrenia and major depressive disorder in the Han Chinese population.	GRM7 GRM8	2.11e-06	2	51	2	26655190
Pubmed	Differential roles of mGlu(7) and mGlu(8) in amygdala-dependent behavior and physiology.	GRM7 GRM8	2.11e-06	2	51	2	23664812
Pubmed	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	SLC6A1 GAD2 INHBA GRM4 GRM7 HCRTR1	5.09e-06	300	51	6	19086053
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRM4 GRM7 GRM8	5.88e-06	24	51	3	35746896
Pubmed	The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors.	QRFPR HCRTR1	6.32e-06	3	51	2	36251705
Pubmed	Distribution of olfactory receptor genes in the human genome.	OR7C2 OR1E2 OR2T1	9.48e-06	28	51	3	9500546
Pubmed	Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder.	GRM7 GRM8	1.26e-05	4	51	2	17167337
Pubmed	The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7.	GRM4 GRM8	3.15e-05	6	51	2	11943148
Pubmed	Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q.	GRM4 GRM8	3.15e-05	6	51	2	8824806
Pubmed	A common variant in DRD3 receptor is associated with autism spectrum disorder.	SLC6A1 GAD2 GRM8 HCRTR1	3.83e-05	128	51	4	19058789
Pubmed	Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion.	GRM4 GRM7	4.41e-05	7	51	2	9920659
Pubmed	Expression of Foxi3 is regulated by ectodysplasin in skin appendage placodes.	INHBA FOXI3	5.87e-05	8	51	2	23441037
Pubmed	Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment.	SLC6A1 GAD2	7.54e-05	9	51	2	15479642
Pubmed	Genetic and molecular evidence of an X-chromosome deletion spanning the tabby (Ta) and testicular feminization (Tfm) loci in the mouse.	PHKA1 DMD	9.42e-05	10	51	2	2055107
Pubmed	Mapping of the phosphorylase kinase alpha subunit gene on the mouse X chromosome.	PHKA1 DMD	9.42e-05	10	51	2	1973380
Pubmed	Characterization of a murine gene expressed from the inactive X chromosome.	PHKA1 DMD	1.15e-04	11	51	2	2034278
Pubmed	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	GAD2 GRM4 GRM7 GRM8	1.18e-04	171	51	4	20201926
Pubmed	Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.	GRM7 GRM8 HCRTR1	1.33e-04	67	51	3	20398908
Pubmed	Mapping of loci and translocation breakpoints in Xq13: isolation of a conserved locus that maps close to CCG1 in human and mouse.	PHKA1 DMD	1.63e-04	13	51	2	8012115
Pubmed	Rps4 maps near the inactivation center on the mouse X chromosome.	PHKA1 DMD	1.63e-04	13	51	2	1740345
Pubmed	XIST and the mapping of the X chromosome inactivation centre.	PHKA1 DMD	1.63e-04	13	51	2	1772416
Pubmed	The murine interleukin-2 receptor gamma chain gene: organization, chromosomal localization and expression in the adult thymus.	PHKA1 DMD	1.63e-04	13	51	2	7805729
Pubmed	Mapping of a liver phosphorylase kinase alpha-subunit gene on the mouse X chromosome.	PHKA1 DMD	1.90e-04	14	51	2	8432533
Pubmed	Oct4 links multiple epigenetic pathways to the pluripotency network.	DNAJC13 BRD4 AFDN SYMPK	2.27e-04	203	51	4	22083510
Pubmed	Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.	GRM4 GRM7 GRM8	2.34e-04	81	51	3	22723691
Pubmed	Regulatory pathway analysis by high-throughput in situ hybridization.	SLC6A1 GAD2 FZD2	3.29e-04	91	51	3	17953485
Pubmed	Megane/Heslike is required for normal GABAergic differentiation in the mouse superior colliculus.	SLC6A1 GAD2	3.55e-04	19	51	2	16968817
Pubmed	mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex.	GRM4 CYFIP2	3.94e-04	20	51	2	23416452
Pubmed	The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex.	SLC6A1 GAD2 GRM8	4.10e-04	98	51	3	19554387
Pubmed	The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates.	OR7C2 OR1E2	5.23e-04	23	51	2	10706615
Pubmed	Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species.	OR1E2 OR2T1	5.70e-04	24	51	2	9119360
Pubmed	Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors.	SLC6A1 GAD2	6.19e-04	25	51	2	31665922
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PHKA1 DNAJC13 NOL10 DMD CYFIP2 FOXC1 SYMPK	8.10e-04	1049	51	7	27880917
Pubmed	A probabilistic classifier for olfactory receptor pseudogenes.	OR2S2 OR51B2	1.22e-03	35	51	2	16939646
Pubmed	HIV-1 subtypes B and C Tat differentially impact synaptic plasticity expression and implicates HIV-associated neurocognitive disorders.	GRM4 GRM7	1.43e-03	38	51	2	25613138
Pubmed	Personal receptor repertoires: olfaction as a model.	OR2S2 OR51B2	1.43e-03	38	51	2	22908908
Cytoband	11q12.1	OR5B3 OR5M9 OR5B2 OR9I1 OR5B17 OR5M3	2.68e-08	161	51	6	11q12.1
Cytoband	Ensembl 112 genes in cytogenetic band chr11q12	OR5B3 OR5M9 OR5B2 OR9I1 OR5B17 OR5M3	2.34e-06	345	51	6	chr11q12
Cytoband	Ensembl 112 genes in cytogenetic band chr5q33	SLC36A3 NMUR2 CYFIP2	3.15e-04	118	51	3	chr5q33
Cytoband	5q33.1	SLC36A3 NMUR2	3.87e-04	26	51	2	5q33.1
Cytoband	19p13.1	OR7C2 BRD4	1.32e-03	48	51	2	19p13.1
Cytoband	Ensembl 112 genes in cytogenetic band chrXp21	CFAP47 DMD	3.98e-03	84	51	2	chrXp21
GeneFamily	Glutamate metabotropic receptors\|Protein phosphatase 1 regulatory subunits	GRM4 GRM7 GRM8	4.76e-07	8	38	3	281
GeneFamily	Olfactory receptors, family 5	OR5B3 OR5M9 OR5B2 OR5B17 OR5M3	3.56e-06	112	38	5	152
ToppCell	facs-Skin-Telogen-3m-Epithelial-outer_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DUOXA1 AFDN DMD FZD2 FOXC1	2.43e-06	196	49	5	c936014125b2ed5f796221b74acb77b8f8359875
Drug	ethylglutamate	GAD2 GRM4 GRM7 GRM8	3.98e-08	16	51	4	CID000014241
Drug	cis-MCG-I	GRM4 GRM7 GRM8	5.88e-07	8	51	3	CID003035584
Drug	AC1N21PP	GRM4 GRM7 GRM8	8.81e-07	9	51	3	CID004014619
Drug	1,3-cyclopentanedicarboxylic acid	GRM4 GRM7 GRM8	8.81e-07	9	51	3	CID000107216
Drug	mM PEP	GRM4 GRM7 GRM8	8.81e-07	9	51	3	CID005311462
Drug	oriens	SLC6A1 GAD2 CHRNA10 GRM4 GRM7 GRM8	1.22e-06	154	51	6	CID000161645
Drug	D-N-Q	SLC6A1 GAD2 GRM4 GRM7 GRM8	1.25e-06	84	51	5	CID000003140
Drug	NS-105	GRM4 GRM7 GRM8	1.26e-06	10	51	3	CID000198695
Drug	benzyloxyaspartate	SLC6A1 GRM4 GRM7 GRM8	1.40e-06	37	51	4	CID004133412
Drug	cyclobutylene AP5	GRM4 GRM7 GRM8	1.73e-06	11	51	3	CID000126582
Drug	AC1NSKBB	GRM4 GRM7 GRM8	2.98e-06	13	51	3	CID005311256
Drug	Mspg	GRM4 GRM7 GRM8	2.98e-06	13	51	3	CID003964410
Drug	MSOPPE	GRM4 GRM7 GRM8	2.98e-06	13	51	3	CID005311463
Drug	cysteine sulfinic acid	GAD2 GRM4 GRM7 GRM8	3.40e-06	46	51	4	CID000000109
Drug	2-methyl-6-styrylpyridine	GRM4 GRM7 GRM8	3.79e-06	14	51	3	CID000235382
Drug	MTPG	GRM4 GRM7 GRM8	3.79e-06	14	51	3	CID005311456
Drug	methylenecyclopropylglycine	GRM4 GRM7 GRM8 SYMPK	4.39e-06	49	51	4	CID000441452
Drug	2-PMPA	GRM4 GRM7 GRM8	5.81e-06	16	51	3	CID010130754
Drug	N-Ac-D-E	GAD2 GRM4 GRM7 GRM8	6.03e-06	53	51	4	CID000005255
Drug	3HPG	GRM4 GRM7 GRM8	7.04e-06	17	51	3	CID000001217
Drug	acromelic acid A	GRM4 GRM7 GRM8	8.44e-06	18	51	3	CID000108086
Drug	aminocyclopentane	GRM4 GRM7 GRM8	1.00e-05	19	51	3	CID000002906
Drug	pyrrolidine-2,4-dicarboxylate	SLC6A1 GRM4 GRM7 GRM8	1.06e-05	61	51	4	CID000003868
Drug	4-carboxy-3-hydroxyphenylglycine	GRM4 GRM7 GRM8	1.18e-05	20	51	3	CID000001297
Drug	3,4-dihydroxyphenylglycine	GRM4 GRM7 GRM8	1.37e-05	21	51	3	CID000027915
Drug	1-amino-2-phosphonomethylcyclopropanecarboxylic acid	GRM4 GRM8	1.47e-05	3	51	2	ctd:C523415
Drug	DCG-IV	GAD2 GRM4 GRM7 GRM8	1.64e-05	68	51	4	CID000115114
Drug	L-Glutamic Acid	GAD2 GRM4 GRM7 GRM8	1.64e-05	68	51	4	DB00142
Drug	MSOP	GRM4 GRM7 GRM8	1.82e-05	23	51	3	CID003964633
Drug	felbamate	GAD2 GRM4 GRM7 GRM8	1.84e-05	70	51	4	CID000003331
Drug	norbiotin	GAD2 GRM4 GRM7 GRM8	2.05e-05	72	51	4	CID000446903
Drug	RS)-2-chloro-5-hydroxyphenylglycine	GRM4 GRM7 GRM8	2.07e-05	24	51	3	CID003645780
Drug	AC1Q3ZOL	SLC6A1 GAD2 CHRNA10 GRM4 GRM7 GRM8	2.35e-05	258	51	6	CID000002376
Drug	2-amino-3-phosphonopropionic acid	GAD2 GRM4 GRM7 GRM8	2.54e-05	76	51	4	CID000003857
Drug	AC1NQH9B	GRM4 GRM7 GRM8	2.65e-05	26	51	3	CID005221504
Drug	MPTP-HCl	GAD2 CHRNA10 GRM4 GRM7 GRM8	3.09e-05	162	51	5	CID000001388
Drug	AC1L1BXF	SLC6A1 GRM4 GRM7 GRM8	3.95e-05	85	51	4	CID000001650
Drug	PBDA	GRM4 GRM7 GRM8	4.12e-05	30	51	3	CID000004408
Drug	memantine	CHRNA10 GRM4 GRM7 GRM8	4.14e-05	86	51	4	CID000004054
Drug	IPSP	SLC6A1 GRM4 GRM7 GRM8	4.33e-05	87	51	4	CID000022083
Drug	NSC298883	NMUR2 GRM4 GRM7 GRM8	4.74e-05	89	51	4	CID000326807
Drug	alpha-methyl-4-carboxyphenylglycine	GRM4 GRM7 GRM8	5.02e-05	32	51	3	CID000001222
Drug	2-amino-4-phosphonobutyric acid	SLC6A1 GRM4 GRM7 GRM8	5.17e-05	91	51	4	CID000002207
Drug	picrotoxin	SLC6A1 GAD2 GRM4 GRM7 GRM8	5.25e-05	181	51	5	CID000031304
Drug	1-aminoindan-1,5-dicarboxylic acid	GRM4 GRM7 GRM8	5.51e-05	33	51	3	CID000002071
Drug	CPPG	GRM4 GRM7 GRM8	6.03e-05	34	51	3	CID000002878
Drug	1m5d	GRM4 GRM7 GRM8	6.59e-05	35	51	3	CID000447082
Drug	baclofen	SLC6A1 GAD2 GRM4 GRM7 GRM8	6.77e-05	191	51	5	CID000002284
Drug	AC1MBZ3L	GRM4 GRM8	7.34e-05	6	51	2	CID002733524
Drug	Proparacaine hydrochloride [5875-06-9]; Up 200; 12uM; HL60; HT_HG-U133A	RDH16 AFDN OR2S2 GRM8 CYFIP2	8.22e-05	199	51	5	3113_UP
Drug	cyclothiazide	GRM4 GRM7 GRM8 SYMPK	8.38e-05	103	51	4	CID000002910
Drug	4CPG	GRM4 GRM7 GRM8	8.45e-05	38	51	3	CID000005115
Drug	L-BMAA	GRM4 GRM7 GRM8	8.45e-05	38	51	3	CID000028558
Drug	4-aminopyrrolidine-2,4-dicarboxylate	GRM4 GRM7 GRM8	9.14e-05	39	51	3	CID003331970
Drug	DETC-MeSO	GRM4 GRM7 GRM8	9.14e-05	39	51	3	CID003035711
Drug	L000369	GRM4 GRM7 GRM8	1.06e-04	41	51	3	CID003931705
Drug	AC1NNRU4	GRM4 GRM7 GRM8	1.06e-04	41	51	3	CID005126051
Drug	butenafine	GRM4 GRM7 GRM8	1.14e-04	42	51	3	CID000002484
Drug	LY341495	GRM4 GRM7 GRM8	1.23e-04	43	51	3	CID006324636
Drug	Joro spider toxin	GRM4 GRM7 GRM8	1.23e-04	43	51	3	CID000119582
Drug	cyclizine	GAD2 GRM4 GRM7 GRM8	1.33e-04	116	51	4	CID000006726
Drug	ibotenic acid	GAD2 GRM4 GRM7 GRM8	1.61e-04	122	51	4	CID000001233
Drug	kynurenic acid	CHRNA10 GRM4 GRM7 GRM8	1.61e-04	122	51	4	CID000003845
Drug	phorbol 12,13-diacetate	GRM4 GRM7 GRM8	1.71e-04	48	51	3	CID000072293
Drug	3-(1H-pyrrole-2-carboxylate	BRD4 DMD GRM4 GRM7 GRM8	1.72e-04	233	51	5	CID000005114
Drug	L-CCG-I	GRM4 GRM7 GRM8	1.93e-04	50	51	3	CID000001271
Drug	AP-5	CHRNA10 GRM4 GRM7 GRM8	1.94e-04	128	51	4	CID000001216
Drug	LY354740	GRM4 GRM7 GRM8	2.04e-04	51	51	3	CID000114827
Drug	AC1L1EKQ	GRM4 GRM7 GRM8	2.17e-04	52	51	3	CID000002834
Drug	2-phenylglycine	GRM4 GRM7 GRM8	2.56e-04	55	51	3	CID000003866
Drug	ganciclovir	GRM4 GRM7 GRM8 GPR148	2.73e-04	140	51	4	CID000003454
Drug	GYKI 52466	GRM4 GRM7 GRM8	3.00e-04	58	51	3	CID000003538
Drug	Dantrolene-13C3	DMD GRM4 GRM7 GRM8	3.13e-04	145	51	4	CID000002951
Drug	MPEP	GRM4 GRM7 GRM8	3.15e-04	59	51	3	CID003025961
Drug	AMN082	GRM7 GRM8	3.20e-04	12	51	2	CID001894360
Drug	pilocarpine-	SLC6A1 GAD2 CHRNA10 GRM8	3.29e-04	147	51	4	CID000004819
Drug	3,5-dihydroxyphenylglycine	GRM4 GRM7 GRM8	3.31e-04	60	51	3	CID000108001
Drug	tetradotoxin	SLC6A1 GAD2 CHRNA10 GRM4 GRM7 GRM8	3.75e-04	428	51	6	CID000020382
Drug	isoflurane	DMD CHRNA10 GRM4 GRM7 GRM8	3.95e-04	279	51	5	CID000003763
Drug	homocysteic acid	GRM4 GRM7 GRM8	4.39e-04	66	51	3	CID000092117
Drug	NO-711	SLC6A1 GAD2 GRM8	4.39e-04	66	51	3	CID000004515
Drug	2-amino-4-phosphonobutyric acid	GRM4 GRM8	4.40e-04	14	51	2	ctd:C012729
Drug	NSC759587	SLC6A1 GAD2 GRM4 GRM7 GRM8 SYMPK	4.56e-04	444	51	6	CID000003816
Drug	MK-801	GAD2 CHRNA10 GRM4 GRM7 GRM8	5.17e-04	296	51	5	CID000001207
Drug	beta-aminobutyric acid	SLC6A1 GAD2	5.79e-04	16	51	2	CID000010932
Drug	AC1L9FMM	GRM4 GRM7 GRM8	5.90e-04	73	51	3	CID000444055
Drug	AC1L1DME	GRM4 GRM7 GRM8	6.38e-04	75	51	3	CID000002414
Drug	gamma-aminobutyric acid	SLC6A1 GAD2 CHRNA10 GRM4 GRM7 GRM8	6.43e-04	474	51	6	CID000000119
Drug	S 254	SLC6A1 GAD2	6.55e-04	17	51	2	CID000029642
Drug	quinolinic acid	GAD2 GRM4 GRM7 GRM8	6.92e-04	179	51	4	CID000001066
Drug	L-quisqualic acid	GAD2 GRM4 GRM7 GRM8	7.07e-04	180	51	4	CID000001209
Drug	hemicholinium-3	SLC6A1 GAD2 CHRNA10	7.16e-04	78	51	3	CID000003585
Drug	phencyclidine	CHRNA10 GRM4 GRM7 GRM8	7.21e-04	181	51	4	CID000006468
Disease	Schizophrenia	SLC6A1 GAD2 GPR50 GRM4 GRM7 GRM8 HCRTR1	2.64e-04	883	43	7	C0036341
Disease	Minimal Brain Dysfunction	GRM7 GRM8	4.70e-04	22	43	2	C1321905
Disease	Attention Deficit Disorder	GRM7 GRM8	4.70e-04	22	43	2	C0041671
Disease	Attention deficit hyperactivity disorder	GRM7 GRM8	5.61e-04	24	43	2	C1263846
Disease	Alcoholic Intoxication, Chronic	SLC6A1 NMUR2 GRM7 GRM8	6.22e-04	268	43	4	C0001973
Disease	retinal degeneration (biomarker_via_orthology)	INHBA DMD	7.65e-04	28	43	2	DOID:8466 (biomarker_via_orthology)
Disease	mosquito bite reaction itch intensity measurement, mosquito bite reaction size measurement	INHBA DMD SLC44A4 GRM8	1.31e-03	328	43	4	EFO_0008377, EFO_0008378
Disease	5-HIAA measurement	SLC6A1 AFDN	1.49e-03	39	43	2	EFO_0005132
Disease	migraine disorder	RDH16 INHBA NMUR2 DMD	1.79e-03	357	43	4	MONDO_0005277
Disease	Mood Disorders	GAD2 GPR50 HCRTR1	1.89e-03	168	43	3	C0525045
Disease	Gastrointestinal Stromal Sarcoma	TMEM17 DMD	2.15e-03	47	43	2	C3179349
Disease	Osteosarcoma	BRD4 GRM4	2.15e-03	47	43	2	C0029463
Disease	Gastrointestinal Stromal Tumors	TMEM17 DMD	2.43e-03	50	43	2	C0238198

Protein segments in the cluster

Peptide	Gene	Start	Entry
PLIGKYYMATMTMVT	CHRNA10	296	Q9GZZ6
PDMRMLSSPKYSLYE	AFDN	81	P55196
DYYKIIKTPMDMGTI	BRD4	96	O60885
SVSLGMLYMPKVYII	GRM4	831	Q14833
KMHYPMVEYCTPTTS	DMD	3351	P11532
CVPTKLRPMSMLYYD	INHBA	391	P08476
PLMVMLILYSKIGYE	QRFPR	226	Q96P65
YVAICKPLRYMSIMS	OR6C70	121	A6NIJ9
IMLIQVDVKLYTPMY	OR9I1	46	Q8NGQ6
RMMEYGTTMVSYQPL	GAD2	536	Q05329
MVMYVSPTYGIPTLL	OR11H4	266	Q8NGC9
MMYISTIVPKMLVNY	OR2T1	121	O43869
MKMVRPPYSYSALIA	FOXI3	141	A8MTJ6
LLPMTVISVLYYLMA	NMUR2	226	Q9GZQ4
EIMVYLAMYMRTQPG	PHKA1	896	P46020
SVADMLVAIYPYPLM	GPR50	71	Q13585
SMVSMPLYAVMYPVF	PDCD10	16	Q9BUL8
PMYYFLTMLAGTDLM	OR51B2	56	Q9Y5P1
YAMIIPMLNPVVYSL	OR5B2	276	Q96R09
YTMVIPMLNPLVYSL	OR5B3	276	Q8NH48
PDFTVYMIKYLMTLI	FZD2	516	Q14332
MLLTANETPKMGIYY	NOL10	326	Q9BSC4
LRYSVIMSKAAYMPM	OR2S2	131	Q9NQN1
YTTVIPMLNPMIYSL	OR5M3	276	Q8NGP4
LLYGHMSYIMPDMLC	PRSS38	216	A1L453
ILETKEPSMMEYVLY	CYFIP2	676	Q96F07
ASVSLGMLYMPKVYI	GRM8	826	O00222
IVTYLAPLGLMAMAY	HCRTR1	221	O43613
MMVPDYAMITEISLY	DNAH1	1706	Q9P2D7
VYLVSAMLLEIPYMA	EIF3CL	686	B5ME19
YEALYMGTLPVTKAM	APBB3	291	O95704
SPDMMKLIIEYAYTR	KLHL10	86	Q6JEL2
MVKPPYSYIALITMA	FOXC1	76	Q12948
EVLMMLPRAMLTYLY	GPR148	306	Q8TDV2
KYAGYPMLIRTITME	DNAJC13	1391	O75165
ALGMLYMPKVYIIIF	GRM7	836	Q14831
MMSTMFYPLVTFVLL	SLC44A4	351	Q53GD3
VMLSMPVLVYGGYML	DUOXA1	196	Q1HG43
LMLMLCVYMYERLPT	CFAP47	1856	Q6ZTR5
MYTVVTPMLTPFIYS	OR1E2	286	P47887
YTMIIPMLSPIVYTL	OR5B17	276	Q8NGF7
MYTMVTPMLNPFIYS	OR7C2	276	O60412
ALSSMVLIPGYMAYM	SLC6A1	541	P30531
VLIPGYMAYMFLTLK	SLC6A1	546	P30531
HLTLPYYKMSGLSMA	HPS3	571	Q969F9
PLIGSMTYSVKEMEY	NXPE4	401	Q6UWF7
YLPMSYMPTFLVDAI	RDH16	291	O75452
VMYTVVTPMLNPLIY	OR7G3	276	Q8NG95
YTTVIPMLNPMIYSL	OR5M9	276	Q8NGP3
SMALIFEYIMEGIPY	SLC36A3	226	Q495N2
SIMMLHMKYSILPDY	TMEM17	61	Q86X19
LISMVYLPEAMPASF	SYMPK	416	Q92797