Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	NADH oxidase H202-forming activity	DUOX1 DUOX2	6.91e-06	2	53	2	GO:0106293
GeneOntologyMolecularFunction	unfolded protein binding	AFG3L2 DNAJB4 DNAJB7 DNAJB5 ERN2	2.08e-05	126	53	5	GO:0051082
GeneOntologyMolecularFunction	NADPH oxidase H202-forming activity	DUOX1 DUOX2	6.88e-05	5	53	2	GO:0106294
GeneOntologyMolecularFunction	RNA polymerase II complex binding	ZNF326 HNRNPU DHX9	1.51e-04	39	53	3	GO:0000993
GeneOntologyMolecularFunction	RNA polymerase core enzyme binding	ZNF326 HNRNPU DHX9	2.32e-04	45	53	3	GO:0043175
GeneOntologyMolecularFunction	K48-linked polyubiquitin modification-dependent protein binding	UFD1 VCP	3.07e-04	10	53	2	GO:0036435
GeneOntologyMolecularFunction	NAD(P)H oxidase H2O2-forming activity	DUOX1 DUOX2	4.49e-04	12	53	2	GO:0016174
GeneOntologyMolecularFunction	superoxide-generating NAD(P)H oxidase activity	DUOX1 DUOX2	4.49e-04	12	53	2	GO:0016175
GeneOntologyMolecularFunction	snRNA binding	NCBP2 DDX21 HNRNPU	4.67e-04	57	53	3	GO:0017069
GeneOntologyMolecularFunction	RNA polymerase binding	ZNF326 HNRNPU DHX9	6.87e-04	65	53	3	GO:0070063
GeneOntologyMolecularFunction	basal RNA polymerase II transcription machinery binding	ZNF326 HNRNPU DHX9	7.18e-04	66	53	3	GO:0001099
GeneOntologyMolecularFunction	basal transcription machinery binding	ZNF326 HNRNPU DHX9	7.18e-04	66	53	3	GO:0001098
GeneOntologyMolecularFunction	chromatin DNA binding	AHDC1 HNRNPU ZIC2 DHX9	1.00e-03	167	53	4	GO:0031490
GeneOntologyMolecularFunction	SUMO binding	HABP4 RNF111	1.15e-03	19	53	2	GO:0032183
GeneOntologyMolecularFunction	RNA helicase activity	DDX21 DDX4 DHX9	1.17e-03	78	53	3	GO:0003724
GeneOntologyMolecularFunction	double-stranded RNA binding	DDX21 HNRNPU DHX9	1.17e-03	78	53	3	GO:0003725
GeneOntologyMolecularFunction	ATP-dependent activity, acting on RNA	DDX21 DDX4 DHX9	1.26e-03	80	53	3	GO:0008186
GeneOntologyMolecularFunction	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	DUOX1 DUOX2	1.27e-03	20	53	2	GO:0050664
GeneOntologyMolecularFunction	ribonucleoprotein complex binding	YTHDF1 HABP4 HNRNPU DHX9	2.17e-03	206	53	4	GO:0043021
GeneOntologyMolecularFunction	mRNA binding	YTHDF1 NCBP2 FUS DDX21 DDX4 HNRNPU DHX9	2.28e-03	694	53	7	GO:0003729
GeneOntologyMolecularFunction	single-stranded RNA binding	HNRNPH1 HNRNPU DHX9	3.20e-03	111	53	3	GO:0003727
GeneOntologyMolecularFunction	phosphatidylcholine binding	PITPNM2 ESYT2	3.67e-03	34	53	2	GO:0031210
GeneOntologyMolecularFunction	nuclear thyroid hormone receptor binding	FUS THRAP3	3.67e-03	34	53	2	GO:0046966
GeneOntologyMolecularFunction	ribosome binding	YTHDF1 HABP4 DHX9	3.98e-03	120	53	3	GO:0043022
GeneOntologyMolecularFunction	poly-pyrimidine tract binding	HNRNPH1 HNRNPU	4.81e-03	39	53	2	GO:0008187
GeneOntologyBiologicalProcess	regulation of RNA splicing	HABP4 ZNF326 HOXB-AS3 FUS THRAP3 HNRNPH1 HNRNPH2 HNRNPU	4.63e-08	207	52	8	GO:0043484
GeneOntologyBiologicalProcess	RNA splicing	NCBP2 HABP4 ZNF326 HOXB-AS3 FUS THRAP3 HNRNPH1 HNRNPH2 HNRNPU DHX9	4.22e-07	502	52	10	GO:0008380
GeneOntologyBiologicalProcess	mRNA processing	NCBP2 HABP4 ZNF326 HOXB-AS3 ERN2 THRAP3 HNRNPH1 HNRNPU DHX9	8.58e-06	551	52	9	GO:0006397
GeneOntologyBiologicalProcess	mRNA metabolic process	YTHDF1 NCBP2 HABP4 ZNF326 HOXB-AS3 FUS ERN2 THRAP3 HNRNPH1 HNRNPU DHX9	1.43e-05	917	52	11	GO:0016071
GeneOntologyBiologicalProcess	cuticle development	DUOX1 DUOX2	1.87e-05	3	52	2	GO:0042335
GeneOntologyBiologicalProcess	mRNA stabilization	FUS THRAP3 HNRNPU DHX9	4.24e-05	77	52	4	GO:0048255
GeneOntologyBiologicalProcess	alternative mRNA splicing, via spliceosome	NCBP2 THRAP3 HNRNPU DHX9	4.69e-05	79	52	4	GO:0000380
GeneOntologyBiologicalProcess	positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	HNRNPU DHX9	6.20e-05	5	52	2	GO:2000373
GeneOntologyBiologicalProcess	regulation of DNA topoisomerase (ATP-hydrolyzing) activity	HNRNPU DHX9	6.20e-05	5	52	2	GO:2000371
GeneOntologyBiologicalProcess	positive regulation of RNA export from nucleus	NCBP2 DHX9	6.20e-05	5	52	2	GO:0046833
GeneOntologyBiologicalProcess	RNA processing	NCBP2 HABP4 ZNF326 HOXB-AS3 FUS ERN2 DDX21 THRAP3 DDX4 HNRNPH1 HNRNPH2 HNRNPU DHX9	6.57e-05	1500	52	13	GO:0006396
GeneOntologyBiologicalProcess	negative regulation of mRNA catabolic process	FUS THRAP3 HNRNPU DHX9	6.85e-05	87	52	4	GO:1902373
GeneOntologyBiologicalProcess	RNA stabilization	FUS THRAP3 HNRNPU DHX9	7.16e-05	88	52	4	GO:0043489
GeneOntologyBiologicalProcess	positive regulation of nucleobase-containing compound transport	NCBP2 DHX9	9.29e-05	6	52	2	GO:0032241
GeneOntologyBiologicalProcess	RNA catabolic process	YTHDF1 NCBP2 FUS ERN2 THRAP3 HNRNPU DHX9	9.99e-05	432	52	7	GO:0006401
GeneOntologyBiologicalProcess	negative regulation of RNA catabolic process	FUS THRAP3 HNRNPU DHX9	1.22e-04	101	52	4	GO:1902369
GeneOntologyBiologicalProcess	positive regulation of isomerase activity	HNRNPU DHX9	1.30e-04	7	52	2	GO:0010912
GeneOntologyBiologicalProcess	regulation of isomerase activity	HNRNPU DHX9	1.30e-04	7	52	2	GO:0010911
GeneOntologyBiologicalProcess	nucleic acid catabolic process	YTHDF1 NCBP2 FUS ERN2 THRAP3 HNRNPU DHX9	1.55e-04	464	52	7	GO:0141188
GeneOntologyBiologicalProcess	negative regulation of mRNA metabolic process	FUS THRAP3 HNRNPU DHX9	2.02e-04	115	52	4	GO:1903312
GeneOntologyBiologicalProcess	nucleobase-containing compound catabolic process	YTHDF1 NCBP2 FUS ERN2 THRAP3 VCP HNRNPU DHX9	3.27e-04	696	52	8	GO:0034655
GeneOntologyBiologicalProcess	CRD-mediated mRNA stabilization	HNRNPU DHX9	3.38e-04	11	52	2	GO:0070934
GeneOntologyBiologicalProcess	mRNA catabolic process	YTHDF1 NCBP2 FUS THRAP3 HNRNPU DHX9	3.39e-04	373	52	6	GO:0006402
GeneOntologyBiologicalProcess	nuclear-transcribed mRNA catabolic process	NCBP2 THRAP3 HNRNPU DHX9	3.42e-04	132	52	4	GO:0000956
GeneOntologyBiologicalProcess	negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	HNRNPU DHX9	4.05e-04	12	52	2	GO:1900152
GeneOntologyBiologicalProcess	positive regulation of mRNA metabolic process	YTHDF1 NCBP2 THRAP3 HNRNPU DHX9	4.82e-04	259	52	5	GO:1903313
GeneOntologyBiologicalProcess	positive regulation of translation	YTHDF1 HABP4 HNRNPU DHX9	5.69e-04	151	52	4	GO:0045727
GeneOntologyBiologicalProcess	regulation of mRNA processing	NCBP2 THRAP3 HNRNPU DHX9	6.74e-04	158	52	4	GO:0050684
GeneOntologyBiologicalProcess	response to topologically incorrect protein	UFD1 DNAJB4 ERN2 VCP	8.11e-04	166	52	4	GO:0035966
GeneOntologyBiologicalProcess	regulation of RNA export from nucleus	NCBP2 DHX9	8.28e-04	17	52	2	GO:0046831
GeneOntologyBiologicalProcess	positive regulation of cytoplasmic translation	HNRNPU DHX9	8.28e-04	17	52	2	GO:2000767
GeneOntologyBiologicalProcess	regulation of mRNA stability	YTHDF1 FUS THRAP3 HNRNPU DHX9	8.29e-04	292	52	5	GO:0043488
GeneOntologyBiologicalProcess	regulation of mRNA metabolic process	YTHDF1 NCBP2 FUS THRAP3 HNRNPU DHX9	8.38e-04	443	52	6	GO:1903311
GeneOntologyBiologicalProcess	regulatory ncRNA processing	NCBP2 HOXB-AS3 DDX4	8.63e-04	74	52	3	GO:0070918
GeneOntologyBiologicalProcess	cytoplasmic translation	NCBP2 RPS10 HNRNPU DHX9	9.25e-04	172	52	4	GO:0002181
GeneOntologyBiologicalProcess	cellular response to misfolded protein	UFD1 VCP	1.04e-03	19	52	2	GO:0071218
GeneOntologyBiologicalProcess	regulation of RNA stability	YTHDF1 FUS THRAP3 HNRNPU DHX9	1.05e-03	308	52	5	GO:0043487
GeneOntologyBiologicalProcess	regulation of mRNA catabolic process	YTHDF1 FUS THRAP3 HNRNPU DHX9	1.07e-03	309	52	5	GO:0061013
GeneOntologyBiologicalProcess	chaperone-mediated protein folding	DNAJB4 DNAJB7 DNAJB5	1.08e-03	80	52	3	GO:0061077
GeneOntologyBiologicalProcess	regulation of nucleobase-containing compound transport	NCBP2 DHX9	1.15e-03	20	52	2	GO:0032239
GeneOntologyBiologicalProcess	response to misfolded protein	UFD1 VCP	1.27e-03	21	52	2	GO:0051788
GeneOntologyBiologicalProcess	hydrogen peroxide biosynthetic process	DUOX1 DUOX2	1.39e-03	22	52	2	GO:0050665
GeneOntologyBiologicalProcess	regulation of translation	YTHDF1 NCBP2 HABP4 TRIM2 HNRNPU DHX9	1.47e-03	494	52	6	GO:0006417
GeneOntologyBiologicalProcess	regulation of translational initiation	YTHDF1 NCBP2 HABP4	1.57e-03	91	52	3	GO:0006446
GeneOntologyCellularComponent	cytoplasmic ribonucleoprotein granule	YTHDF1 HABP4 DDX4 VCP HNRNPU DHX9	5.94e-05	269	53	6	GO:0036464
GeneOntologyCellularComponent	ribonucleoprotein granule	YTHDF1 HABP4 DDX4 VCP HNRNPU DHX9	8.49e-05	287	53	6	GO:0035770
GeneOntologyCellularComponent	CRD-mediated mRNA stability complex	HNRNPU DHX9	9.40e-05	6	53	2	GO:0070937
GeneOntologyCellularComponent	VCP-NPL4-UFD1 AAA ATPase complex	UFD1 VCP	1.75e-04	8	53	2	GO:0034098
GeneOntologyCellularComponent	NADPH oxidase complex	DUOX1 DUOX2	9.40e-04	18	53	2	GO:0043020
Domain	DUOX1	DUOX1 DUOX2	7.90e-06	2	53	2	IPR029595
Domain	AKAP95	ZNF326 AKAP8	2.37e-05	3	53	2	IPR007071
Domain	zf-RNPHF	HNRNPH1 HNRNPH2	2.37e-05	3	53	2	PF08080
Domain	Znf_CHHC	HNRNPH1 HNRNPH2	2.37e-05	3	53	2	IPR012996
Domain	ZF_C2H2_AKAP95	ZNF326 AKAP8	2.37e-05	3	53	2	PS51799
Domain	AKAP95	ZNF326 AKAP8	2.37e-05	3	53	2	PF04988
Domain	DnaJ_domain_CS	DNAJB4 DNAJB7 DNAJB5	6.01e-05	27	53	3	IPR018253
Domain	Asp_de-COase-like_dom	UFD1 VCP	7.86e-05	5	53	2	IPR009010
Domain	NAD_binding_6	DUOX1 DUOX2	1.64e-04	7	53	2	PF08030
Domain	FAD_binding_8	DUOX1 DUOX2	1.64e-04	7	53	2	PF08022
Domain	FAD-bd_8	DUOX1 DUOX2	1.64e-04	7	53	2	IPR013112
Domain	Fe_red_NAD-bd_6	DUOX1 DUOX2	1.64e-04	7	53	2	IPR013121
Domain	DnaJ_C	DNAJB4 DNAJB5	2.81e-04	9	53	2	IPR002939
Domain	DnaJ_C	DNAJB4 DNAJB5	2.81e-04	9	53	2	PF01556
Domain	HSP40/DnaJ_pept-bd	DNAJB4 DNAJB5	2.81e-04	9	53	2	IPR008971
Domain	DnaJ	DNAJB4 DNAJB7 DNAJB5	3.41e-04	48	53	3	PF00226
Domain	Haem_peroxidase	DUOX1 DUOX2	3.50e-04	10	53	2	IPR010255
Domain	An_peroxidase	DUOX1 DUOX2	3.50e-04	10	53	2	PF03098
Domain	PEROXIDASE_3	DUOX1 DUOX2	3.50e-04	10	53	2	PS50292
Domain	Haem_peroxidase_animal	DUOX1 DUOX2	3.50e-04	10	53	2	IPR019791
Domain	-	DUOX1 DUOX2	3.50e-04	10	53	2	1.10.640.10
Domain	DNAJ_1	DNAJB4 DNAJB7 DNAJB5	3.62e-04	49	53	3	PS00636
Domain	DNAJ_2	DNAJB4 DNAJB7 DNAJB5	3.62e-04	49	53	3	PS50076
Domain	DnaJ	DNAJB4 DNAJB7 DNAJB5	3.62e-04	49	53	3	SM00271
Domain	-	DNAJB4 DNAJB7 DNAJB5	3.62e-04	49	53	3	1.10.287.110
Domain	DnaJ_domain	DNAJB4 DNAJB7 DNAJB5	4.08e-04	51	53	3	IPR001623
Domain	Ferric_reduct	DUOX1 DUOX2	5.12e-04	12	53	2	PF01794
Domain	Fe3_Rdtase_TM_dom	DUOX1 DUOX2	5.12e-04	12	53	2	IPR013130
Domain	Nucleotide-bd_a/b_plait	NCBP2 FUS DDX21 HNRNPH1 HNRNPH2	8.08e-04	258	53	5	IPR012677
Domain	DEAD/DEAH_box_helicase_dom	DDX21 DDX4 DHX9	1.17e-03	73	53	3	IPR011545
Domain	DEAD	DDX21 DDX4 DHX9	1.17e-03	73	53	3	PF00270
Domain	Fd_Rdtase_FAD-bd	DUOX1 DUOX2	1.31e-03	19	53	2	IPR017927
Domain	FAD_FR	DUOX1 DUOX2	1.31e-03	19	53	2	PS51384
Domain	Riboflavin_synthase-like_b-brl	DUOX1 DUOX2	1.31e-03	19	53	2	IPR017938
Domain	RRM_1	NCBP2 FUS HNRNPH1 HNRNPH2	2.86e-03	208	53	4	PF00076
Domain	ATPase_AAA_CS	AFG3L2 VCP	3.05e-03	29	53	2	IPR003960
Domain	RRM	NCBP2 FUS HNRNPH1 HNRNPH2	3.33e-03	217	53	4	SM00360
Domain	Helicase_C	DDX21 DDX4 DHX9	3.48e-03	107	53	3	PF00271
Domain	HELICc	DDX21 DDX4 DHX9	3.48e-03	107	53	3	SM00490
Domain	DEAD_ATP_HELICASE	DDX21 DDX4	3.49e-03	31	53	2	PS00039
Domain	Helicase_C	DDX21 DDX4 DHX9	3.57e-03	108	53	3	IPR001650
Domain	HELICASE_CTER	DDX21 DDX4 DHX9	3.66e-03	109	53	3	PS51194
Domain	HELICASE_ATP_BIND_1	DDX21 DDX4 DHX9	3.66e-03	109	53	3	PS51192
Domain	DEXDc	DDX21 DDX4 DHX9	3.66e-03	109	53	3	SM00487
Domain	Helicase_ATP-bd	DDX21 DDX4 DHX9	3.76e-03	110	53	3	IPR014001
Domain	RRM_dom	NCBP2 FUS HNRNPH1 HNRNPH2	3.91e-03	227	53	4	IPR000504
Domain	RNA-helicase_DEAD-box_CS	DDX21 DDX4	3.94e-03	33	53	2	IPR000629
Domain	RRM	NCBP2 FUS HNRNPH1 HNRNPH2	4.09e-03	230	53	4	PS50102
Domain	AAA	AFG3L2 VCP	4.18e-03	34	53	2	PS00674
Domain	Q_MOTIF	DDX21 DDX4	4.94e-03	37	53	2	PS51195
Domain	RNA_helicase_DEAD_Q_motif	DDX21 DDX4	4.94e-03	37	53	2	IPR014014
Domain	-	NCBP2 FUS HNRNPH1 HNRNPH2	5.04e-03	244	53	4	3.30.70.330
Pathway	WP_MRNA_PROCESSING	NCBP2 FUS HNRNPH1 HNRNPH2 HNRNPU DHX9	1.57e-06	126	41	6	M39406
Pathway	WP_MRNA_PROCESSING	NCBP2 AFG3L2 FUS DDX21 DDX4 HNRNPH1 HNRNPH2 HNRNPU DHX9	4.57e-06	451	41	9	MM15946
Pathway	REACTOME_MRNA_SPLICING	NCBP2 FUS HNRNPH1 HNRNPH2 HNRNPU DHX9	2.31e-05	201	41	6	MM15411
Pathway	REACTOME_MRNA_SPLICING	NCBP2 FUS HNRNPH1 HNRNPH2 HNRNPU DHX9	3.12e-05	212	41	6	M14033
Pathway	REACTOME_METABOLISM_OF_RNA	NCBP2 RPS10 PSMB5 FUS DDX21 HNRNPH1 HNRNPH2 HNRNPU DHX9	5.20e-05	612	41	9	MM15547
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA	NCBP2 FUS HNRNPH1 HNRNPH2 HNRNPU DHX9	1.38e-04	277	41	6	MM15414
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA	NCBP2 FUS HNRNPH1 HNRNPH2 HNRNPU DHX9	1.55e-04	283	41	6	M13087
Pathway	REACTOME_METABOLISM_OF_RNA	NCBP2 RPS10 PSMB5 FUS DDX21 HNRNPH1 HNRNPH2 HNRNPU DHX9	1.88e-04	724	41	9	M16843
Pathway	REACTOME_THYROXINE_BIOSYNTHESIS	DUOX1 DUOX2	2.93e-04	9	41	2	MM14833
Pathway	REACTOME_THYROXINE_BIOSYNTHESIS	DUOX1 DUOX2	3.66e-04	10	41	2	M27120
Pathway	KEGG_MEDICUS_REFERENCE_TRAIP_DEPENDENT_REPLISOME_DISASSEMBLY	UFD1 VCP	9.65e-04	16	41	2	M47862
Pathway	REACTOME_METABOLISM_OF_AMINE_DERIVED_HORMONES	DUOX1 DUOX2	1.09e-03	17	41	2	MM14829
Pathway	REACTOME_METABOLISM_OF_AMINE_DERIVED_HORMONES	DUOX1 DUOX2	1.23e-03	18	41	2	M27118
Pathway	WP_MECP2_AND_ASSOCIATED_RETT_SYNDROME	FUS HNRNPH1 DHX9	1.23e-03	73	41	3	M39401
Pathway	REACTOME_TRANSLESION_SYNTHESIS_BY_POLH	UFD1 VCP	1.37e-03	19	41	2	M26899
Pathway	REACTOME_TRANSLESION_SYNTHESIS_BY_POLH	UFD1 VCP	1.37e-03	19	41	2	MM14477
Pathway	REACTOME_KEAP1_NFE2L2_PATHWAY	UFD1 PSMB5 VCP	1.44e-03	77	41	3	MM15698
Pubmed	SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.	YTHDF1 HABP4 ZNF326 AKAP8 RPS10 FUS API5 DDX21 THRAP3 HNRNPH1 HNRNPH2 PRRC2B	7.10e-15	258	55	12	37794589
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	YTHDF1 ZNF326 AKAP8 DNAJB4 MIB2 FUS DNAJB5 DDX21 WDR26 THRAP3 HNRNPH1 HNRNPH2 PRRC2B HNRNPU	1.16e-14	462	55	14	31138677
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	YTHDF1 NCBP2 ZNF326 AKAP8 RPS10 DIDO1 FUS API5 DDX21 THRAP3 HNRNPH1 HNRNPH2 PRRC2B VCP HNRNPU DHX9	7.81e-14	807	55	16	22681889
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	YTHDF1 ESYT2 ZNF326 RPS10 DNAJB4 APPL1 FUS API5 DNAJB5 DDX21 WDR26 HNRNPH1 VCP DHX9	9.25e-13	638	55	14	33239621
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	ZNF326 AKAP8 FUS API5 DDX21 WDR26 THRAP3 HNRNPH1 HNRNPH2 PRRC2B VCP HNRNPU DHX9	2.72e-12	551	55	13	34728620
Pubmed	PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.	YTHDF1 NCBP2 ZNF326 AKAP8 RPS10 FUS DDX21 THRAP3 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	3.59e-11	678	55	13	30209976
Pubmed	Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.	YTHDF1 ZNF326 AKAP8 RPS10 FUS DDX21 THRAP3 HNRNPH1 HNRNPH2 HNRNPU DHX9	5.33e-11	421	55	11	34650049
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	NCBP2 ZNF326 AKAP8 UFD1 AFG3L2 RPS10 PSMB5 FUS API5 DDX21 WDR26 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	1.47e-10	1335	55	16	29229926
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	ZNF326 AKAP8 FUS DDX21 THRAP3 HNRNPH1 VCP HNRNPU DHX9	1.71e-10	244	55	9	29884807
Pubmed	Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop.	YTHDF1 AKAP8 FUS DDX21 THRAP3 HNRNPH1 PRRC2B HNRNPU DHX9	2.99e-10	260	55	9	36199071
Pubmed	Beads-free protein immunoprecipitation for a mass spectrometry-based interactome and posttranslational modifications analysis.	ZNF326 AKAP8 FUS DDX21 HNRNPH1 HNRNPH2 HNRNPU DHX9	3.03e-10	172	55	8	26336360
Pubmed	Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation.	RPS10 DDX21 THRAP3 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	3.03e-10	172	55	8	23184937
Pubmed	Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy.	ZNF326 DDX21 THRAP3 HNRNPH1 HNRNPH2 HNRNPU DHX9	4.38e-10	109	55	7	29511296
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	NCBP2 ESYT2 ZNF326 AKAP8 AFG3L2 RPS10 DIDO1 FUS DDX21 AHDC1 THRAP3 HNRNPH1 HNRNPH2 HNRNPU DHX9	9.83e-10	1294	55	15	30804502
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	YTHDF1 NCBP2 ZNF326 AKAP8 RPS10 FUS DDX21 THRAP3 HNRNPH1 HNRNPH2 HNRNPU DHX9	9.86e-10	713	55	12	29802200
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	YTHDF1 NCBP2 KRT75 RPS10 PSMB5 FUS DDX21 THRAP3 DDX4 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	2.19e-09	1153	55	14	29845934
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	KRT75 UFD1 AFG3L2 RPS10 PSMB5 DNAJB4 DIDO1 FUS DDX21 THRAP3 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	3.31e-09	1415	55	15	28515276
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	ZNF326 AKAP8 UFD1 RPS10 DIDO1 FUS DDX21 THRAP3 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	3.53e-09	989	55	13	36424410
Pubmed	The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer.	ZNF326 RPS10 FUS HNRNPH1 HNRNPH2 VCP DHX9	3.57e-09	147	55	7	28977470
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	ZNF326 PSMB5 FUS DDX21 THRAP3 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	3.61e-09	477	55	10	31300519
Pubmed	Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis.	DNAJB4 FUS THRAP3 HNRNPH1 PRRC2B VCP HNRNPU DHX9	3.69e-09	236	55	8	36339263
Pubmed	Nucleolar localization of DGCR8 and identification of eleven DGCR8-associated proteins.	FUS HNRNPH1 HNRNPU DHX9	3.96e-09	13	55	4	17765891
Pubmed	A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins.	RPS10 HNRNPH1 HNRNPH2 HNRNPU DHX9	3.96e-09	38	55	5	18247557
Pubmed	SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.	ESYT2 AFG3L2 RPS10 MIB2 FUS THRAP3 HNRNPH1 VCP HNRNPU	4.35e-09	353	55	9	27545878
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	ZNF326 AKAP8 PSMB5 FUS DDX21 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	5.04e-09	494	55	10	26831064
Pubmed	Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.	ZNF326 RPS10 DIDO1 FUS API5 DDX21 THRAP3 HNRNPH1 VCP HNRNPU DHX9	5.24e-09	652	55	11	31180492
Pubmed	Regulation of MAGE-A3/6 by the CRL4-DCAF12 ubiquitin ligase and nutrient availability.	PSMB5 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	6.20e-09	89	55	6	31267705
Pubmed	DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation.	ZNF326 AKAP8 DDX21 HNRNPH1 HNRNPH2 DHX9	6.20e-09	89	55	6	22446626
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	ESYT2 AKAP8 UFD1 AFG3L2 RPS10 PSMB5 FUS DDX21 WDR26 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	6.58e-09	1257	55	14	37317656
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	ZNF326 AKAP8 EXPH5 AFG3L2 RPS10 PSMB5 DIDO1 FUS DDX21 THRAP3 HNRNPH1 HNRNPH2 HNRNPU DHX9	6.58e-09	1257	55	14	36526897
Pubmed	A protein-RNA interaction atlas of the ribosome biogenesis factor AATF.	NCBP2 ZNF326 RPS10 DDX21 THRAP3 HNRNPH1 DHX9	7.02e-09	162	55	7	31363146
Pubmed	The protein interaction landscape of the human CMGC kinase group.	CDKN2B ESYT2 AKAP8 AFG3L2 PSMB5 PELI2 DIDO1 DDX21 THRAP3 HNRNPH2 DHX9	1.01e-08	695	55	11	23602568
Pubmed	Ubiquilin 2 modulates ALS/FTD-linked FUS-RNA complex dynamics and stress granule formation.	ESYT2 AFG3L2 FUS HNRNPH1 PRRC2B VCP HNRNPU DHX9	1.03e-08	269	55	8	30442662
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	ESYT2 UFD1 AFG3L2 RPS10 PSMB5 DDX21 WDR26 HNRNPH1 HNRNPH2 VCP	1.05e-08	534	55	10	35032548
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	NCBP2 AKAP8 DDX21 WDR26 THRAP3 HNRNPH1 HNRNPH2 HNRNPU	1.12e-08	272	55	8	31010829
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	AKAP8 FUS DDX21 THRAP3 HNRNPH1 VCP HNRNPU DHX9	1.18e-08	274	55	8	34244482
Pubmed	Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.	YTHDF1 ZNF326 AKAP8 RPS10 DDX21 THRAP3 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	1.33e-08	714	55	11	28302793
Pubmed	SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.	AFG3L2 RPS10 PSMB5 FUS THRAP3 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	1.60e-08	558	55	10	27591049
Pubmed	USP11 mediates repair of DNA-protein cross-links by deubiquitinating SPRTN metalloprotease.	ESYT2 ZNF326 AFG3L2 RPS10 THRAP3 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	1.80e-08	565	55	10	33567341
Pubmed	Comprehensive proteomic analysis of the human spliceosome.	NCBP2 FUS HNRNPH1 HNRNPH2 HNRNPU DHX9	2.11e-08	109	55	6	12226669
Pubmed	TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence.	ZNF326 RPS10 FUS DDX21 THRAP3 HNRNPH1 HNRNPH2 HNRNPU DHX9	2.39e-08	430	55	9	38172120
Pubmed	Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.	ZNF326 DDX21 HNRNPH2 HNRNPU DHX9	3.23e-08	57	55	5	17932509
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	ZNF326 AKAP8 RPS10 FUS API5 DDX21 THRAP3 HNRNPH1 HNRNPU DHX9	3.41e-08	605	55	10	28977666
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	ZNF326 AFG3L2 RPS10 PSMB5 FUS API5 DDX21 AHDC1 THRAP3 HNRNPH1 VCP HNRNPU DHX9	5.44e-08	1247	55	13	27684187
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	ZNF326 AKAP8 AFG3L2 RPS10 FUS DDX21 THRAP3 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	5.44e-08	1024	55	12	24711643
Pubmed	Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.	KRT75 DIDO1 FUS DDX21 THRAP3 HNRNPU DHX9	5.78e-08	220	55	7	24550385
Pubmed	Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.	NCBP2 ZNF326 EXPH5 RPS10 DDX21 THRAP3 HNRNPH1 VCP HNRNPU DHX9	5.85e-08	641	55	10	36057605
Pubmed	SPOP attenuates migration and invasion of choriocarcinoma cells by promoting DHX9 degradation.	RPS10 PSMB5 FUS HNRNPH1 HNRNPU DHX9	6.06e-08	130	55	6	32905556
Pubmed	LINKIN, a new transmembrane protein necessary for cell adhesion.	AKAP8 RPS10 FUS DDX21 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	6.11e-08	480	55	9	25437307
Pubmed	BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.	ZNF326 AFG3L2 RPS10 HNRNPH1 HNRNPH2 HNRNPU ZIC2	6.94e-08	226	55	7	25900982
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	ESYT2 AKAP8 RPS10 FUS DDX21 THRAP3 HNRNPH1 PRRC2B HNRNPU DHX9	7.15e-08	655	55	10	35819319
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	YTHDF1 RPS10 PSMB5 FUS DDX21 THRAP3 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	7.28e-08	844	55	11	25963833
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	YTHDF1 ZNF326 AKAP8 RPS10 FUS DDX21 AHDC1 THRAP3 VCP HNRNPU DHX9	7.55e-08	847	55	11	35850772
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	ZNF326 DNAJB7 FUS API5 DDX21 THRAP3 HNRNPH1 HNRNPH2 VCP DHX9	7.68e-08	660	55	10	32780723
Pubmed	Immunoprecipitation and mass spectrometry defines an extensive RBM45 protein-protein interaction network.	RPS10 FUS THRAP3 HNRNPH1 HNRNPU DHX9	7.92e-08	136	55	6	26979993
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	ZNF326 AKAP8 RPS10 DIDO1 DDX21 AHDC1 THRAP3 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	9.88e-08	1082	55	12	38697112
Pubmed	Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity.	DDX21 HNRNPH1 HNRNPU DHX9	1.11e-07	28	55	4	38492217
Pubmed	SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.	ZNF326 FUS API5 DDX21 THRAP3 HNRNPU DHX9	1.20e-07	245	55	7	35652658
Pubmed	Dido3-dependent SFPQ recruitment maintains efficiency in mammalian alternative splicing.	DIDO1 HNRNPU DHX9	1.30e-07	7	55	3	30931476
Pubmed	Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.	UFD1 RPS10 PSMB5 DDX21 HNRNPH1 VCP HNRNPU DHX9	1.38e-07	377	55	8	25147182
Pubmed	Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.	ESYT2 RPS10 PSMB5 FUS DDX21 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	1.45e-07	707	55	10	19738201
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	RPS10 FUS API5 DDX21 THRAP3 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	1.53e-07	711	55	10	33022573
Pubmed	Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.	YTHDF1 AKAP8 DDX21 THRAP3 HNRNPH1 HNRNPH2 PRRC2B VCP HNRNPU DHX9	1.78e-07	723	55	10	34133714
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	NCBP2 ESYT2 AFG3L2 RPS10 FUS DDX21 HNRNPH1 HNRNPH2 HNRNPU DHX9	1.83e-07	725	55	10	27025967
Pubmed	Shotgun proteomics and network analysis of ubiquitin-related proteins from human breast carcinoma epithelial cells.	PSMB5 HNRNPH1 HNRNPU DHX9	1.95e-07	32	55	4	21853274
Pubmed	Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation.	RPS10 FUS DDX21 HNRNPH1 VCP HNRNPU DHX9	2.38e-07	271	55	7	26816005
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	YTHDF1 ZNF326 RPS10 DIDO1 FUS API5 DDX21 THRAP3 HNRNPH1 HNRNPU DHX9	2.48e-07	954	55	11	36373674
Pubmed	Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.	ESYT2 AKAP8 UFD1 DDX21 THRAP3 VCP HNRNPU DHX9	2.52e-07	408	55	8	33766124
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	ZNF326 AKAP8 FUS API5 DDX21 THRAP3 HNRNPH1 HNRNPU DHX9	3.10e-07	582	55	9	20467437
Pubmed	PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays.	FUS HNRNPU DHX9	3.12e-07	9	55	3	11850402
Pubmed	Endogenous human MDM2-C is highly expressed in human cancers and functions as a p53-independent growth activator.	ALDH16A1 VCP HNRNPU DHX9	3.17e-07	36	55	4	24147044
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	ALDH16A1 UFD1 RPS10 PSMB5 DNAJB4 APPL1 FUS API5 WDR26 HNRNPH1 VCP HNRNPU DHX9	3.21e-07	1455	55	13	22863883
Pubmed	A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.	RPS10 FUS THRAP3 HNRNPH1 PRRC2B HNRNPU DHX9	3.42e-07	286	55	7	32041737
Pubmed	HIV-1 Vif promotes the G₁- to S-phase cell-cycle transition.	DDX21 HNRNPU DHX9	4.46e-07	10	55	3	21149631
Pubmed	Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity.	UFD1 PSMB5 FUS DNAJB5 VCP	4.50e-07	96	55	5	34599178
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	ZNF326 AKAP8 PPP1R14C HOXB-AS3 CSPG4 MIB2 FUS API5 AHDC1 HNRNPH1 HNRNPU	4.85e-07	1021	55	11	26760575
Pubmed	Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing.	DDX21 THRAP3 HNRNPU DHX9	4.90e-07	40	55	4	23825951
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	NCBP2 RPS10 DDX21 AHDC1 THRAP3 HNRNPH1 PRRC2B HNRNPU DHX9	4.91e-07	615	55	9	31048545
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	ESYT2 RPS10 FUS DDX21 WDR26 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	4.98e-07	809	55	10	32129710
Pubmed	Expanded CUG repeats Dysregulate RNA splicing by altering the stoichiometry of the muscleblind 1 complex.	HNRNPH1 HNRNPH2 DHX9	6.12e-07	11	55	3	21900255
Pubmed	KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer.	DDX21 HNRNPH1 VCP HNRNPU DHX9	6.70e-07	104	55	5	36055981
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	YTHDF1 UFD1 RPS10 PSMB5 DDX21 HNRNPH1 VCP HNRNPU DHX9	6.75e-07	639	55	9	23443559
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	NCBP2 ESYT2 ZNF326 AFG3L2 DIDO1 FUS DDX21 THRAP3 HNRNPH1 HNRNPH2 HNRNPU DHX9	8.09e-07	1318	55	12	30463901
Pubmed	Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production.	FUS DDX21 HNRNPH1 HNRNPH2 HNRNPU DHX9	9.14e-07	206	55	6	22174317
Pubmed	A cohesin-RAD21 interactome.	RPS10 DNAJB4 API5 HNRNPH2 HNRNPU DHX9	9.67e-07	208	55	6	22145905
Pubmed	Quantitative analysis of PPT1 interactome in human neuroblastoma cells.	FUS HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	1.02e-06	210	55	6	26217791
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ZNF326 UFD1 AFG3L2 RPS10 PSMB5 DDX21 THRAP3 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	1.07e-06	1353	55	12	29467282
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	YTHDF1 AKAP8 DIDO1 FUS HNRNPH1 HNRNPU DHX9	1.09e-06	340	55	7	24332808
Pubmed	Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome.	FUS HNRNPH1 HNRNPH2 DHX9	1.12e-06	49	55	4	27352031
Pubmed	The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase.	ZNF326 RPS10 FUS HNRNPH1 HNRNPU DHX9	1.34e-06	220	55	6	34091597
Pubmed	GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.	ESYT2 AFG3L2 DDX21 THRAP3 VCP DHX9	1.38e-06	221	55	6	29991511
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	YTHDF1 PITPNM2 ESYT2 AFG3L2 APPL1 MIB2 WDR26 THRAP3 HNRNPH2 VCP HNRNPU	1.41e-06	1139	55	11	36417873
Pubmed	Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.	PSMB5 WDR26 HNRNPH1 HNRNPU DHX9	1.60e-06	124	55	5	23000965
Pubmed	Interactome and Ubiquitinome Analyses Identify Functional Targets of Herpes Simplex Virus 1 Infected Cell Protein 0.	ESYT2 PSMB5 HNRNPH2 VCP DHX9	1.60e-06	124	55	5	35516420
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	ZNF326 AKAP8 DNAJB4 FUS DDX21 THRAP3 HNRNPH1 PRRC2B VCP HNRNPU DHX9	1.62e-06	1155	55	11	20360068
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	YTHDF1 NCBP2 AKAP8 RPS10 WDR26 THRAP3 HNRNPH1 HNRNPH2 VCP DHX9	1.62e-06	922	55	10	27609421
Pubmed	An LRP16-containing preassembly complex contributes to NF-κB activation induced by DNA double-strand breaks.	DDX21 HNRNPU DHX9	1.68e-06	15	55	3	25735744
Pubmed	The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation.	AKAP8 RPS10 VCP HNRNPU	1.80e-06	55	55	4	31640799
Pubmed	Defining the membrane proteome of NK cells.	SLC22A18 ESYT2 AKAP8 ALDH16A1 RPS10 API5 DDX21 HNRNPH1 HNRNPH2 HNRNPU DHX9	1.80e-06	1168	55	11	19946888
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	AKAP8 DNAJB4 FUS THRAP3 HNRNPU ZIC2	1.82e-06	232	55	6	25515538
Interaction	DCUN1D1 interactions	ZNF326 KRT75 UFD1 RPS10 FUS API5 DDX4 HNRNPH1 HNRNPH2 HNRNPU DHX9	1.42e-10	275	54	11	int:DCUN1D1
Interaction	FBXW11 interactions	ZNF326 AKAP8 RPS10 DNAJB4 FUS DNAJB5 THRAP3 HNRNPH1 HNRNPH2 VCP HNRNPU ZIC2 DHX9	2.57e-10	473	54	13	int:FBXW11
Interaction	SNRPC interactions	NCBP2 HABP4 ZNF326 AKAP8 DIDO1 FUS DDX21 THRAP3 HNRNPH1 HNRNPH2 HNRNPU DHX9	1.51e-09	440	54	12	int:SNRPC
Interaction	RC3H2 interactions	YTHDF1 NCBP2 ZNF326 AKAP8 AFG3L2 RPS10 FUS DDX21 THRAP3 HNRNPH1 HNRNPH2 PRRC2B HNRNPU DHX9	1.58e-09	667	54	14	int:RC3H2
Interaction	FAM120A interactions	YTHDF1 ZNF326 RPS10 FUS DDX21 HNRNPH1 HNRNPH2 PRRC2B VCP HNRNPU DHX9	1.77e-09	349	54	11	int:FAM120A
Interaction	RC3H1 interactions	YTHDF1 NCBP2 ZNF326 AFG3L2 RPS10 FUS DDX21 THRAP3 HNRNPH1 HNRNPH2 PRRC2B VCP HNRNPU DHX9	1.91e-09	677	54	14	int:RC3H1
Interaction	PRMT1 interactions	YTHDF1 HABP4 ZNF326 AKAP8 FUS API5 DDX21 WDR26 THRAP3 HNRNPH1 HNRNPH2 PRRC2B VCP HNRNPU DHX9	1.29e-08	929	54	15	int:PRMT1
Interaction	TRIM31 interactions	YTHDF1 ZNF326 AKAP8 RPS10 FUS DDX21 THRAP3 HNRNPH1 HNRNPH2 HNRNPU DHX9	2.69e-08	454	54	11	int:TRIM31
Interaction	STIP1 interactions	YTHDF1 ESYT2 ZNF326 UFD1 RPS10 DNAJB4 APPL1 FUS API5 DNAJB5 DDX21 WDR26 HNRNPH1 VCP DHX9	3.72e-08	1006	54	15	int:STIP1
Interaction	SNRPA interactions	YTHDF1 NCBP2 ZNF326 AKAP8 DIDO1 FUS API5 DDX21 THRAP3 HNRNPU DHX9	4.95e-08	482	54	11	int:SNRPA
Interaction	BTRC interactions	YTHDF1 AKAP8 UFD1 AFG3L2 RPS10 FUS DDX21 THRAP3 HNRNPH1 PRRC2B VCP HNRNPU DHX9	9.38e-08	775	54	13	int:BTRC
Interaction	AR interactions	ZNF326 EXPH5 ALDH16A1 PSMB5 DIDO1 APPL1 AHDC1 THRAP3 HNRNPH1 HNRNPH2 PRRC2B VCP HNRNPU DHX9	2.29e-07	992	54	14	int:AR
Interaction	MEPCE interactions	YTHDF1 KRT75 RPS10 PSMB5 FUS DDX21 THRAP3 DDX4 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	3.06e-07	859	54	13	int:MEPCE
Interaction	MYCN interactions	YTHDF1 NCBP2 HABP4 ZNF326 AKAP8 RPS10 DIDO1 FUS DDX21 THRAP3 DDX4 HNRNPH1 HNRNPH2 PRRC2B HNRNPU DHX9	3.51e-07	1373	54	16	int:MYCN
Interaction	CLUH interactions	NCBP2 ZNF326 PSMB5 DIDO1 APPL1 FUS THRAP3 HNRNPH2	4.68e-07	263	54	8	int:CLUH
Interaction	RECQL4 interactions	NCBP2 ZNF326 AKAP8 UFD1 AFG3L2 RPS10 PSMB5 FUS API5 DDX21 WDR26 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	5.11e-07	1412	54	16	int:RECQL4
Interaction	SNRPF interactions	NCBP2 ZNF326 DIDO1 FUS DDX21 WDR26 THRAP3 HNRNPU DHX9	7.68e-07	385	54	9	int:SNRPF
Interaction	ACE2 interactions	YTHDF1 NCBP2 ZNF326 EXPH5 RPS10 APPL1 FUS DDX21 THRAP3 HNRNPH1 PRRC2B VCP HNRNPU DHX9	8.53e-07	1106	54	14	int:ACE2
Interaction	PSPC1 interactions	YTHDF1 ZNF326 RPS10 DNAJB4 FUS DDX21 PRRC2B VCP HNRNPU DHX9	9.49e-07	515	54	10	int:PSPC1
Interaction	SNRPB interactions	NCBP2 ZNF326 AKAP8 DIDO1 FUS API5 THRAP3 HNRNPH1 HNRNPU DHX9	9.83e-07	517	54	10	int:SNRPB
Interaction	MATR3 interactions	ZNF326 TRIM2 AKAP8 FUS DDX21 THRAP3 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	1.05e-06	655	54	11	int:MATR3
Interaction	BMI1 interactions	YTHDF1 NCBP2 HABP4 ZNF326 AKAP8 RPS10 PSMB5 DIDO1 FUS THRAP3 PRRC2B	1.12e-06	659	54	11	int:BMI1
Interaction	CPSF6 interactions	NCBP2 ZNF326 AKAP8 RPS10 DIDO1 FUS API5 THRAP3 HNRNPU DHX9	1.15e-06	526	54	10	int:CPSF6
Interaction	RBM45 interactions	AFG3L2 RPS10 FUS THRAP3 HNRNPH1 HNRNPU DHX9	1.28e-06	207	54	7	int:RBM45
Interaction	SNRNP70 interactions	YTHDF1 NCBP2 ZNF326 AKAP8 RPS10 FUS DDX21 THRAP3 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	1.42e-06	984	54	13	int:SNRNP70
Interaction	FXR1 interactions	YTHDF1 HABP4 AKAP8 DIDO1 API5 THRAP3 HNRNPH1 HNRNPH2 PRRC2B VCP HNRNPU	1.50e-06	679	54	11	int:FXR1
Interaction	MAGEA3 interactions	PSMB5 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	1.53e-06	134	54	6	int:MAGEA3
Interaction	SMURF1 interactions	ZNF326 AKAP8 RPS10 DDX21 THRAP3 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	1.56e-06	544	54	10	int:SMURF1
Interaction	DUX4 interactions	RPS10 FUS DDX21 HNRNPH1 VCP HNRNPU DHX9	1.60e-06	214	54	7	int:DUX4
Interaction	HNRNPK interactions	ZNF326 AKAP8 PELI2 DIDO1 FUS API5 DDX21 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	2.03e-06	853	54	12	int:HNRNPK
Interaction	GLDC interactions	AKAP8 FUS DDX21 THRAP3 HNRNPH1 VCP HNRNPU DHX9	2.09e-06	321	54	8	int:GLDC
Interaction	TSR1 interactions	HABP4 RPS10 DNAJB4 DDX21 WDR26 HNRNPH1 VCP HNRNPU	2.14e-06	322	54	8	int:TSR1
Interaction	DDX5 interactions	ZNF326 AKAP8 FUS DDX21 THRAP3 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	2.29e-06	568	54	10	int:DDX5
Interaction	CYLD interactions	ALDH16A1 AFG3L2 RPS10 PSMB5 MIB2 FUS THRAP3 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	2.44e-06	868	54	12	int:CYLD
Interaction	SYNCRIP interactions	YTHDF1 NCBP2 HABP4 FUS DDX21 HNRNPH1 HNRNPH2 PRRC2B VCP HNRNPU DHX9	2.68e-06	721	54	11	int:SYNCRIP
Interaction	RBM39 interactions	YTHDF1 NCBP2 ZNF326 AKAP8 RPS10 FUS DDX21 THRAP3 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	2.68e-06	1042	54	13	int:RBM39
Interaction	HNRNPM interactions	ZNF326 RPS10 DNAJB7 FUS API5 DDX21 THRAP3 HNRNPH1 HNRNPH2 HNRNPU DHX9	2.75e-06	723	54	11	int:HNRNPM
Interaction	CAND1 interactions	NCBP2 ZNF326 AKAP8 KRT75 RPS10 FUS THRAP3 DDX4 HNRNPH1 HNRNPH2 HNRNPU DHX9	3.31e-06	894	54	12	int:CAND1
Interaction	SPRTN interactions	ESYT2 ZNF326 UFD1 AFG3L2 RPS10 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	3.52e-06	596	54	10	int:SPRTN
Interaction	FBP1 interactions	RPS10 DIDO1 FUS THRAP3 HNRNPH1 PRRC2B HNRNPU DHX9	3.80e-06	348	54	8	int:FBP1
Interaction	HEXIM1 interactions	KRT75 RPS10 PSMB5 FUS DDX21 THRAP3 DDX4 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	4.10e-06	913	54	12	int:HEXIM1
Interaction	FUS interactions	ZNF326 AKAP8 UFD1 DIDO1 FUS DDX21 THRAP3 HNRNPH1 VCP HNRNPU DHX9	4.27e-06	757	54	11	int:FUS
Interaction	CHD3 interactions	HABP4 ZNF326 AKAP8 RPS10 FUS API5 DDX21 THRAP3 HNRNPH1 HNRNPU DHX9	4.27e-06	757	54	11	int:CHD3
Interaction	GRIN2D interactions	FUS HNRNPH1 VCP HNRNPU	4.33e-06	41	54	4	int:GRIN2D
Interaction	NAGK interactions	AKAP8 AHDC1 HNRNPH1 HNRNPH2 PRRC2B ZIC2	4.62e-06	162	54	6	int:NAGK
Interaction	USP14 interactions	UFD1 RPS10 PSMB5 API5 DDX21 HNRNPH1 VCP HNRNPU DHX9	5.46e-06	489	54	9	int:USP14
Interaction	WWOX interactions	ESYT2 KRT75 AFG3L2 DIDO1 FUS DDX21 THRAP3 HNRNPH1 HNRNPU DHX9	5.50e-06	627	54	10	int:WWOX
Interaction	LARP7 interactions	NCBP2 HABP4 KRT75 RPS10 PSMB5 FUS DDX21 THRAP3 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	5.52e-06	1113	54	13	int:LARP7
Interaction	MAPT interactions	YTHDF1 TRIM2 UFD1 AFG3L2 RPS10 PSMB5 FUS API5 WDR26 HNRNPH1 VCP HNRNPU DHX9	5.85e-06	1119	54	13	int:MAPT
Interaction	ISG15 interactions	UFD1 PSMB5 DNAJB4 FUS DNAJB5 THRAP3 VCP HNRNPU DHX9	5.93e-06	494	54	9	int:ISG15
Interaction	EIF4A3 interactions	NCBP2 KRT75 FUS API5 DDX21 THRAP3 HNRNPH1 HNRNPH2 HNRNPU	6.43e-06	499	54	9	int:EIF4A3
Interaction	PCDHA2 interactions	DIDO1 DDX21 HNRNPU	6.48e-06	14	54	3	int:PCDHA2
Interaction	RTCB interactions	ZNF326 UFD1 APPL1 FUS API5 HNRNPH1 HNRNPU DHX9	6.57e-06	375	54	8	int:RTCB
Interaction	AATF interactions	NCBP2 ZNF326 RPS10 DDX21 THRAP3 HNRNPH1 HNRNPU DHX9	6.70e-06	376	54	8	int:AATF
Interaction	C9orf72 interactions	ESYT2 AKAP8 UFD1 AFG3L2 RPS10 PSMB5 FUS DDX21 WDR26 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	6.73e-06	1319	54	14	int:C9orf72
Interaction	UBQLN2 interactions	ESYT2 UFD1 AFG3L2 PSMB5 FUS HNRNPH1 HNRNPH2 PRRC2B VCP HNRNPU DHX9	6.97e-06	797	54	11	int:UBQLN2
Interaction	HOXB-AS3 interactions	HOXB-AS3 HNRNPH1	7.05e-06	2	54	2	int:HOXB-AS3
Interaction	NCL interactions	RPS10 DIDO1 MIB2 FUS API5 DDX21 THRAP3 HNRNPH1 PRRC2B HNRNPU DHX9	7.06e-06	798	54	11	int:NCL
Interaction	NEDD8 interactions	KRT75 UFD1 RPS10 FUS HNRNPH1 HNRNPH2 HNRNPU DHX9	9.25e-06	393	54	8	int:NEDD8
Interaction	AGO1 interactions	YTHDF1 ZNF326 DDX21 HNRNPH2 HNRNPU DHX9	9.29e-06	183	54	6	int:AGO1
Interaction	PINK1 interactions	ZNF326 PSMB5 FUS DDX21 THRAP3 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	1.11e-05	679	54	10	int:PINK1
Interaction	DIMT1 interactions	HABP4 API5 THRAP3 PRRC2B HNRNPU DHX9	1.12e-05	189	54	6	int:DIMT1
Interaction	NUPR1 interactions	ZNF326 DNAJB7 FUS API5 DDX21 THRAP3 HNRNPH1 HNRNPH2 VCP DHX9	1.16e-05	683	54	10	int:NUPR1
Interaction	USP10 interactions	YTHDF1 HABP4 RPS10 DDX21 VCP HNRNPU DHX9	1.18e-05	290	54	7	int:USP10
Interaction	HNRNPUL2 interactions	ZNF326 FUS DDX21 HNRNPH1 HNRNPH2 VCP DHX9	1.21e-05	291	54	7	int:HNRNPUL2
Interaction	ITFG1 interactions	AKAP8 RPS10 FUS DDX21 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	1.21e-05	540	54	9	int:ITFG1
Interaction	PABPN1 interactions	DNAJB4 FUS DDX21 HNRNPH1 HNRNPU DHX9	1.22e-05	192	54	6	int:PABPN1
Interaction	FN1 interactions	ESYT2 RPS10 PSMB5 PELI2 FUS DDX21 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	1.25e-05	848	54	11	int:FN1
Interaction	NPM1 interactions	RPS10 DNAJB4 DIDO1 FUS API5 DDX21 WDR26 HNRNPH1 HNRNPH2 PRRC2B VCP HNRNPU DHX9	1.25e-05	1201	54	13	int:NPM1
Interaction	RNF113A interactions	ESYT2 AKAP8 RPS10 FUS DDX21 THRAP3 HNRNPH1 PRRC2B HNRNPU DHX9	1.30e-05	692	54	10	int:RNF113A
Interaction	AURKA interactions	NCBP2 ZNF326 AKAP8 RPS10 PSMB5 FUS THRAP3 HNRNPH2 HNRNPU DHX9	1.37e-05	696	54	10	int:AURKA
Interaction	TOP1 interactions	NCBP2 ZNF326 AKAP8 PSMB5 DIDO1 DDX21 THRAP3 VCP HNRNPU DHX9	1.37e-05	696	54	10	int:TOP1
Interaction	RNF4 interactions	SLC22A18 ESYT2 ZNF326 CSPG4 AFG3L2 RPS10 FUS FAM241B THRAP3 HNRNPH1 VCP HNRNPU RNF111 DHX9	1.46e-05	1412	54	14	int:RNF4
Interaction	ZFR interactions	RPS10 FUS DDX21 HNRNPH1 VCP HNRNPU DHX9	1.50e-05	301	54	7	int:ZFR
Interaction	SOX2 interactions	YTHDF1 NCBP2 ESYT2 AKAP8 FUS DDX21 WDR26 AHDC1 THRAP3 HNRNPH1 HNRNPH2 PRRC2B HNRNPU DHX9	1.58e-05	1422	54	14	int:SOX2
Interaction	SCARNA22 interactions	FUS DDX21 HNRNPH1 HNRNPU DHX9	1.59e-05	118	54	5	int:SCARNA22
Interaction	KIF20A interactions	AKAP8 RPS10 DIDO1 FUS DDX21 THRAP3 DDX4 HNRNPH2 PRRC2B VCP HNRNPU DHX9	1.72e-05	1052	54	12	int:KIF20A
Interaction	TRIP4 interactions	RPS10 FUS DDX21 THRAP3 HNRNPU DHX9	1.82e-05	206	54	6	int:TRIP4
Interaction	SRSF1 interactions	HABP4 ZNF326 RPS10 DIDO1 FUS THRAP3 HNRNPH1 HNRNPU DHX9	1.86e-05	570	54	9	int:SRSF1
Interaction	EFTUD2 interactions	UFD1 AFG3L2 RPS10 PSMB5 DNAJB4 DIDO1 FUS DDX21 THRAP3 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	1.96e-05	1449	54	14	int:EFTUD2
Interaction	ARIH2 interactions	RPS10 FUS DDX21 HNRNPH1 VCP HNRNPU DHX9	1.97e-05	314	54	7	int:ARIH2
Interaction	ERCC8 interactions	RPS10 PSMB5 DNAJB4 VCP DHX9	2.02e-05	124	54	5	int:ERCC8
Interaction	NLRP8 interactions	DNAJB4 DNAJB5	2.11e-05	3	54	2	int:NLRP8
Interaction	THRAP3 interactions	AKAP8 FUS API5 DDX21 THRAP3 VCP HNRNPU DHX9	2.19e-05	443	54	8	int:THRAP3
Interaction	HDAC4 interactions	PITPNM2 HABP4 TMEM121B DNAJB5 DDX21 THRAP3 PRRC2B VCP HNRNPU DHX9	2.43e-05	744	54	10	int:HDAC4
Interaction	MACROD1 interactions	DDX21 HNRNPH1 HNRNPU DHX9	2.44e-05	63	54	4	int:MACROD1
Interaction	PNO1 interactions	NCBP2 DDX21 WDR26 VCP HNRNPU	2.45e-05	129	54	5	int:PNO1
Interaction	MECP2 interactions	ZNF326 AKAP8 RPS10 DIDO1 FUS DDX21 AHDC1 THRAP3 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	2.61e-05	1287	54	13	int:MECP2
Interaction	RBM42 interactions	NCBP2 ZNF326 RPS10 DDX21 THRAP3 HNRNPU DHX9	2.76e-05	331	54	7	int:RBM42
Interaction	MOV10 interactions	YTHDF1 HABP4 ZNF326 UFD1 RPS10 PSMB5 DNAJB4 FUS DDX21 HNRNPH2 PRRC2B HNRNPU DHX9	2.83e-05	1297	54	13	int:MOV10
Interaction	ERG interactions	PSMB5 DDX21 HNRNPH1 PRRC2B HNRNPU RNF111	2.85e-05	223	54	6	int:ERG
Interaction	ZNF326 interactions	ZNF326 FUS DDX21 HNRNPH1 VCP DHX9	2.92e-05	224	54	6	int:ZNF326
Interaction	STAG2 interactions	AKAP8 DDX21 THRAP3 HNRNPH1 VCP HNRNPU	2.92e-05	224	54	6	int:STAG2
Interaction	RPL4 interactions	ZNF326 PPP1R14C RPS10 DNAJB7 FUS API5 DDX21 AHDC1 HNRNPU DHX9	3.05e-05	764	54	10	int:RPL4
Interaction	HSF1 interactions	ZNF326 DNAJB4 FUS THRAP3 HNRNPH1 PRRC2B VCP HNRNPU DHX9	3.13e-05	609	54	9	int:HSF1
Interaction	NFX1 interactions	RPS10 PSMB5 FUS WDR26 HNRNPH1 VCP HNRNPU DHX9	3.15e-05	466	54	8	int:NFX1
Interaction	MAU2 interactions	AKAP8 THRAP3 HNRNPH1 HNRNPH2 HNRNPU	3.15e-05	136	54	5	int:MAU2
Interaction	CHD4 interactions	ZNF326 AKAP8 AFG3L2 RPS10 FUS API5 DDX21 THRAP3 HNRNPH1 HNRNPU DHX9	3.19e-05	938	54	11	int:CHD4
Interaction	PHB1 interactions	NCBP2 ESYT2 ALDH16A1 AFG3L2 RPS10 FUS DDX21 HNRNPH1 HNRNPH2 VCP HNRNPU DHX9	3.28e-05	1123	54	12	int:PHB1
Interaction	MIR138-1 interactions	FUS DDX21 HNRNPH1 HNRNPH2	3.30e-05	68	54	4	int:MIR138-1
Cytoband	15q15.3	DUOX1 DUOX2	4.15e-04	25	55	2	15q15.3
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	DNAJB4 DNAJB7 DNAJB5	1.48e-04	49	38	3	584
GeneFamily	RNA binding motif containing	NCBP2 FUS HNRNPH1 HNRNPH2	1.01e-03	213	38	4	725
GeneFamily	DEAD-box helicases	DDX21 DDX4	3.51e-03	42	38	2	499
GeneFamily	AAA ATPases	AFG3L2 VCP	5.54e-03	53	38	2	413
Coexpression	BIDUS_METASTASIS_UP	YTHDF1 NCBP2 PPP1R14C DDX21 HNRNPU ZIC2	6.19e-06	221	54	6	M15866
Coexpression	MILI_PSEUDOPODIA_CHEMOTAXIS_DN	CSPG4 RPS10 DIDO1 FUS WDR26 THRAP3 VCP	4.08e-05	457	54	7	M1613
Coexpression	MILI_PSEUDOPODIA_CHEMOTAXIS_DN	CSPG4 RPS10 DIDO1 FUS WDR26 THRAP3 VCP	4.88e-05	470	54	7	MM1053
Coexpression	GSE45837_WT_VS_GFI1_KO_PDC_UP	TRIM2 DNAJB4 DDX21 THRAP3 HNRNPH1	5.09e-05	195	54	5	M9892
Coexpression	GSE3691_IFN_PRODUCING_KILLER_DC_VS_PLASMACYTOID_DC_SPLEEN_DN	NCBP2 DDX21 THRAP3 GPR179 DHX9	5.61e-05	199	54	5	M6365
Coexpression	GSE37301_LYMPHOID_PRIMED_MPP_VS_RAG2_KO_NK_CELL_UP	AKAP8 PELI2 FUS DDX21 THRAP3	5.61e-05	199	54	5	M8863
ToppCell	NS-critical-d_07-13\|critical / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DUOX1 TRIM2 EXPH5 DUOX2 ERN2	4.17e-06	198	54	5	a6e11c87b31beffb6af190c64b4ef3ee1d9dab8d
ToppCell	facs-Tongue-nan-3m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	API5 HNRNPH1 HNRNPH2 VCP HNRNPU	4.27e-06	199	54	5	8d50e1ee58710d896c0204937331d9f4dcd38de0
ToppCell	10x5'-GI_large-bowel-Lymphocytic_T_CD8-Tem/emra_CD8\|GI_large-bowel / Manually curated celltypes from each tissue	DUOX1 HOXB-AS3 PELI2 ERN2	4.89e-05	166	54	4	13bef304ea3df8e8d2bc376a3287c78220a1b0c6
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-SMG_basal_2\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	PPP1R14C KREMEN2 CSPG4 DUOX2	6.14e-05	176	54	4	045b12c90f7dd49a9778dadcdf8f18125b380531
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_D_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPP6 PPP1R14C GPR179 DHX9	6.56e-05	179	54	4	7c8a2fa1326c73dc9e774df645b572864fd97133
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_D_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPP6 PPP1R14C GPR179 DHX9	6.70e-05	180	54	4	8bf6e8b6b45ce42f8c5f23e7cd1752ec8b3fa2d2
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LTBP2 WDR26 HNRNPH1 HNRNPU	8.26e-05	190	54	4	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CDKN2B TRIM2 DUOX2 ERN2	8.26e-05	190	54	4	6ea9fa08bd97bedcb21d3654467e7f8dd74c8fd0
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CSPG4 HRC DNAJB4 LTBP2	8.78e-05	193	54	4	800b0f5705fefcd3608e37801afae8a94474723e
ToppCell	Transplant_Alveoli_and_parenchyma-Mesenchymal-Smooth_muscle\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	HOXB-AS3 CSPG4 HRC LTBP2	8.78e-05	193	54	4	9104b572d9c3c99080e4b7455993fbb944bf117d
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HNRNPH1 HNRNPH2 VCP HNRNPU	9.32e-05	196	54	4	66d76249bd2770cdddff2c1fe59a016e95da2124
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HNRNPH1 HNRNPH2 VCP HNRNPU	9.32e-05	196	54	4	9bd4c146fc7555e32adfa393b3a07846eb826d25
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HNRNPH1 HNRNPH2 VCP HNRNPU	9.32e-05	196	54	4	151f1a29a91f8b234e9b6ed062666357a2f69128
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-skeletal_muscle_satellite_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDX21 HNRNPH2 VCP HNRNPU	9.50e-05	197	54	4	5bc11aff92da2a0aca8473f997fe7a99f3cae75d
ToppCell	facs-Tongue-nan-3m-Epithelial\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	API5 HNRNPH1 HNRNPH2 VCP	9.69e-05	198	54	4	2f03f8897dd7cce6d8296638e14e11ec16bcf624
ToppCell	facs-Tongue-nan-3m\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	API5 HNRNPH1 HNRNPH2 VCP	9.69e-05	198	54	4	f2a4057f038ef7225a5b98a7ab068c30dff4eadd
ToppCell	facs-Tongue-nan-3m-Epithelial-basal_cell_of_epidermis\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	API5 HNRNPH1 HNRNPH2 VCP	9.69e-05	198	54	4	22559b161e67b49fe8028bfaf861e069063599f5
ToppCell	cellseq-Mesenchymal-Myocytic\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	HOXB-AS3 CSPG4 HRC LTBP2	9.88e-05	199	54	4	20e62a7029fa0d214244cdf2a481fc5d78290438
ToppCell	Parenchymal-10x3prime_v2-Stromal-Myofibroblastic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CSPG4 HRC DNAJB4 DNAJB5	9.88e-05	199	54	4	9a08c25bb4851ad4ac9db8916422280f71378c2c
ToppCell	Parenchymal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	HOXB-AS3 CSPG4 HRC LTBP2	9.88e-05	199	54	4	7c272a1aa7f3e931ad5d20809719d85b3bce4cb0
ToppCell	Parenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CSPG4 HRC DNAJB4 DNAJB5	9.88e-05	199	54	4	2ed10c5e15c9d5ed0a8bea580842348d5698a07b
ToppCell	(00)_Basal\|World / shred by cell type by condition	DUOX1 RPS10 DUOX2 DDX21	9.88e-05	199	54	4	bc0201e77a1690e3e0a6ecd05cd105e1f5c0ba7b
ToppCell	TCGA-Bile_Duct-Primary_Tumor\|TCGA-Bile_Duct / Sample_Type by Project: Shred V9	YTHDF1 AKAP8 FUS HNRNPU	1.01e-04	200	54	4	0350e5ffd36033099b7e32a1fdd790fff99790dc
ToppCell	Bronchial-10x5prime-Epithelial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DUOX1 TRIM2 PPP1R14C EXPH5	1.01e-04	200	54	4	d3ee5f79513e2ac02ad3329b59e6290d457c44d2
ToppCell	Parenchyma_COVID-19-Epithelial-TX\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	DUOX1 TRIM2 PPP1R14C EXPH5	1.01e-04	200	54	4	d5426cd318a8f90c0bd8f9804351ab230fafc995
ToppCell	Lung_Parenchyma-Severe-Epithelial-Epithelial\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DUOX1 TRIM2 PPP1R14C EXPH5	1.01e-04	200	54	4	21d9cf3cd3696ad6b745c7c036798f04b6ce5160
ToppCell	TCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma\|TCGA-Bile_Duct / Sample_Type by Project: Shred V9	YTHDF1 AKAP8 FUS HNRNPU	1.01e-04	200	54	4	ad2a6da0b1ae7a9212a3c91e5eec4baa7481d8dc
ToppCell	Lung_Parenchyma-Severe-Epithelial\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	DUOX1 TRIM2 PPP1R14C EXPH5	1.01e-04	200	54	4	33658d5d09e2eaff60f4dd88837d4252328eab63
ToppCell	lung-Type_I_Pneumocytes\|lung / shred on tissue and cell subclass	TRIM2 AFG3L2 DNAJB5	1.35e-04	82	54	3	6023212a51f8b3e05e6c3dcf4e8fbf53ba696fb2
Computational	Neighborhood of DDX5	FUS HNRNPH1 HNRNPU DHX9	6.92e-05	65	37	4	GCM_DDX5
Disease	phenylketonuria (implicated_via_orthology)	DUOX1 DUOX2	1.97e-05	4	54	2	DOID:9281 (implicated_via_orthology)
Disease	autosomal dominant limb-girdle muscular dystrophy type 1 (implicated_via_orthology)	DNAJB4 DNAJB5	1.97e-05	4	54	2	DOID:0110305 (implicated_via_orthology)
Disease	congenital myopathy 21 (implicated_via_orthology)	DNAJB4 DNAJB5	1.97e-05	4	54	2	DOID:0081353 (implicated_via_orthology)
Disease	Frontotemporal Dementia With Motor Neuron Disease	FUS VCP	9.14e-05	8	54	2	C3888102
Disease	Glaucoma	CDKN2B LTBP2	1.17e-04	9	54	2	C0017601
Disease	primary bacterial infectious disease (implicated_via_orthology)	DUOX1 DUOX2	1.17e-04	9	54	2	DOID:0050338 (implicated_via_orthology)
Disease	neurodegenerative disease (implicated_via_orthology)	UFD1 AFG3L2 PSMB5 VCP	1.46e-04	145	54	4	DOID:1289 (implicated_via_orthology)
Disease	Amyotrophic Lateral Sclerosis	DPP6 FUS VCP	1.66e-04	58	54	3	C0002736
Disease	frontotemporal dementia (implicated_via_orthology)	FUS VCP	2.14e-04	12	54	2	DOID:9255 (implicated_via_orthology)
Disease	hypothyroidism (implicated_via_orthology)	DUOX1 DUOX2	2.53e-04	13	54	2	DOID:1459 (implicated_via_orthology)
Disease	congenital hypothyroidism (implicated_via_orthology)	DUOX1 DUOX2	2.95e-04	14	54	2	DOID:0050328 (implicated_via_orthology)
Disease	Amyotrophic lateral sclerosis	FUS VCP	4.39e-04	17	54	2	cv:C0002736
Disease	response to quetiapine	DNAJB5 VCP	1.21e-03	28	54	2	GO_0097335
Disease	Amyotrophic Lateral Sclerosis With Dementia	DPP6 FUS	1.29e-03	29	54	2	C0393554
Disease	Amyotrophic Lateral Sclerosis, Guam Form	DPP6 FUS	1.48e-03	31	54	2	C0543859
Disease	amyotrophic lateral sclerosis (is_implicated_in)	DPP6 FUS	1.57e-03	32	54	2	DOID:332 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RGSIPRQSFFNRGHG	FAM241B	26	Q96D05
QRRSAFGFDDGNFPG	ESYT2	31	A0FGR8
FGRFGFNGLSRGPRR	DNAJB5	141	O75953
QAPLAFQAGGRRGDF	CSPG4	236	Q6UVK1
GNNSEASGPYRRGGR	DDX4	136	Q9NQI0
FVGGRFQAPGARSSR	ALDH16A1	531	Q8IZ83
AVGRKRGRGNFGGQS	AFG3L2	411	Q9Y4W6
GSLDGFMRGRGQGRF	AKAP8	181	O43823
NYEQRGAFRGSRGGR	API5	496	Q9BZZ5
TQFNQPVGGGGFRRA	AHDC1	1171	Q5TGY3
NGPRGLYAFGAERGN	DUOX1	226	Q9NRD9
EGRQYGRGRSGGQVR	NCBP2	121	P52298
PHQRRRFQAAGGGAE	HOXB-AS3	11	C0HLZ6
GQFGFPEGRSGRLLQ	GPR179	341	Q6PRD1
GFNKFGGPRDQGSRH	FUS	261	P35637
LGRGAGGTFVFRGQF	ERN2	526	Q76MJ5
AFGQGGRRTNPFGES	APPL1	471	Q9UKG1
QNGPRGLYAFGAERG	DUOX2	231	Q9NRD8
GRGGPGNRVFDAFDQ	HABP4	196	Q5JVS0
GRGYNSIGRGAGFER	HNRNPH2	216	P55795
HRGRGGFNMRGGNFR	HNRNPU	706	Q00839
FGRSGEQRRFGQGPF	EXPH5	466	Q8NEV8
GADYRGHQNRTGPRG	KREMEN2	41	Q8NCW0
GRGYNSIGRGAGFER	HNRNPH1	216	P31943
GSFGLPGQGDFLRSR	PITPNM2	1276	Q9BZ72
NRPGSSYGNRNRDAG	DNAJB7	121	Q7Z6W7
NPFEIFFGRRMGGGR	DNAJB4	106	Q9UDY4
AGADPNGVNRFGRRA	CDKN2B	36	P42772
SRGGAPFQFGGQRRP	DIDO1	1881	Q9BTC0
AGGDANRLRRPGGSY	LTBP2	46	Q14767
YGGFRGQREGSRGFR	DDX21	721	Q9NR30
GQREGSRGFRGQRDG	DDX21	726	Q9NR30
GGAGGRPRFQYQARS	DPP6	61	P42658
VSRGGFRGNSGGDYR	DHX9	1221	Q08211
QRFRERQAGGGAAPG	MIB2	791	Q96AX9
GGGARVFFQSPRGGA	PPP1R14C	16	Q8TAE6
RGNRASPSRARGGYG	TMEM121B	521	Q9BXQ6
GYNGALPNGDRGRRK	PELI2	26	Q9HAT8
RGDGLGFRNRNNSTG	HRC	31	P23327
QNSRQRHGPGSGFPR	PROB1	76	E7EW31
GPVFGRFADQRGARA	SLC22A18	76	Q96BI1
GEERNRGNFPPRFSG	TRBV5-8	71	A0A5A2
SATEFQFRGGFGRGR	RPS10	146	P46783
GGGRARGTFQFRARG	THRAP3	826	Q9Y2W1
GLDGTSFRGPFRGNF	RNF111	866	Q6ZNA4
RGFGSFRFPSGNQGG	VCP	766	P55072
CSRQGGGNGFLRFRQ	SPDYC	41	Q5MJ68
FREFTFRGRPAGGNG	PRRC2B	1071	Q5JSZ5
GSNRRGPGRAEGTFF	UNQ9370/PRO34162	51	Q6UXP9
RAAQGLGFRGSGQRA	nan	81	Q6ZRN7
GELGFRAFSGSGNRL	UFD1	221	Q92890
PDGKRFVTGGQRGQF	WDR26	456	Q9H7D7
RFGSRGNGDRQFAGP	TRIM2	611	Q9C040
LPVNQRGFFGLGGRA	PSMB5	11	P28074
PRNRNAAFGQSGGAG	YTHDF1	331	Q9BYJ9
FRSRGFGDSAPGGGQ	ZIC2	121	O95409
NEPEQSRFGGSYGGR	ZNF326	96	Q5BKZ1
RSGFGGRASNRFGVN	KRT75	81	O95678