Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessprotein farnesylation

COX10 FNTA

1.90e-055292GO:0018343
DomainhnRNP_C

HNRNPC RALYL

3.48e-056292IPR017347
DomainLRR_6

NLRP1 TLR4

3.29e-0355292PF13516
DomainRRM_dom

SYNJ2 HNRNPC RALYL

5.13e-03227293IPR000504
DomainRRM

SYNJ2 HNRNPC RALYL

5.32e-03230293PS50102
Domain-

SYNJ2 HNRNPC RALYL

6.26e-032442933.30.70.330
DomainNucleotide-bd_a/b_plait

SYNJ2 HNRNPC RALYL

7.30e-03258293IPR012677
Pubmed

Association of Nod-like receptor protein-1 (rs2670660) and Toll-like receptor-4 (rs4986790) with non-segmental vitiligo: A case-control study in South Indian population.

NLRP1 TLR4

6.71e-07229231293094
Pubmed

Dominant-negative alpha-subunit of farnesyl- and geranyltransferase inhibits glucose-stimulated, but not KCl-stimulated, insulin secretion in INS 832/13 cells.

COX10 FNTA

2.01e-06329217192483
Pubmed

Frequencies of genetic polymorphisms of TLR4 and CD14 and of HLA-DQ genotypes in children with celiac disease, type 1 diabetes mellitus, or both.

HLA-DQB1 TLR4

4.02e-06429218728522
Pubmed

Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B.

USP4 AURKB

4.02e-06429218728397
Pubmed

Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1β production in acute glaucoma.

NLRP1 TLR4

6.70e-06529225024200
Pubmed

Systems genetic analysis of hippocampal neuroanatomy and spatial learning in mice.

RALYL FBXW5

6.07e-051429226449520
Pubmed

Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.

KLC2 SYNJ2 SHCBP1

8.47e-0510229315778465
Pubmed

Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS.

SYNJ2 HNRNPC SHCBP1

1.00e-0410829319531213
Pubmed

Novel Cul3 binding proteins function to remodel E3 ligase complexes.

NLRP1 FBXW5

5.13e-044029225011449
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

KLC2 KCTD12 FNTA HNRNPC SHCBP1 MEN1

5.73e-04128429617353931
GeneFamilyRNA binding motif containing

HNRNPC RALYL

2.07e-02213192725
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Lgi2_(Golgi_interneuron)|Cerebellum / BrainAtlas - Mouse McCarroll V32

MCMDC2 PFKFB1 SHCBP1 NPC1L1

1.82e-0777294ec8f625cae561986ed27dfaefa8f822dd1c4fba1
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Lgi2_(Golgi_interneuron)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

MCMDC2 PFKFB1 SHCBP1 NPC1L1

1.82e-0777294af7e1e76db33b115238b6fc61fc0dd86aab8e49d
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Lgi2_(Golgi_interneuron)--|Cerebellum / BrainAtlas - Mouse McCarroll V32

MCMDC2 PFKFB1 SHCBP1 NPC1L1

1.82e-0777294afe990041849a68fd75e0c11b633a7b90fefade1
ToppCellCOVID-19-kidney-PCT-S3-2|kidney / Disease (COVID-19 only), tissue and cell type

PFKFB1 C8B SARDH NPC1L1

4.76e-061742945aa2fb631505600f37d2b87b02def7be139dc262
ToppCellCOVID-19-kidney-PCT-S3-2|COVID-19 / Disease (COVID-19 only), tissue and cell type

PFKFB1 C8B SARDH NPC1L1

4.98e-06176294b6497324e3e52f514ce556a3fa0c3011c45dcc7b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KCTD12 NLRP1 C12orf56 SYNJ2

6.46e-06188294c2c51c6526defe2600302901159b8abbb58d7595
ToppCell3'_v3-GI_small-bowel-Myeloid_Mac-Cycling_Myeloid-Mac|GI_small-bowel / Manually curated celltypes from each tissue

KCTD12 HLA-DQB1 SHCBP1 AURKB

6.88e-06191294c3944332c5226b0113f8aa9ac07837b755606c6c
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KCTD12 GPR155 HLA-DQB1 TLR4

7.32e-06194294ad72be9f6871b334e1f477d868c15e7792fadea5
ToppCellmyeloid-pro-cDC|World / Lineage and Cell class

KCTD12 HLA-DQB1 SHCBP1 AURKB

8.09e-0619929405652da8747d608b515324f90b3a70155a9c9898
ToppCellTransverse-(5)_Dendritic_cell-(52)_cycling_DCs|Transverse / shred on region, Cell_type, and subtype

KCTD12 SHCBP1 TLR4 AURKB

8.25e-0620029451e643d48b5e97a0e117b578a6ea7d429c6cdd1e
ToppCellTransverse-Dendritic_cell-cycling_DCs|Transverse / Region, Cell class and subclass

KCTD12 SHCBP1 TLR4 AURKB

8.25e-06200294f588d8889f351c797963616a3575fa43efd46b9a
ToppCell(52)_cycling_DCs|World / shred on Cell_type and subtype

KCTD12 SHCBP1 TLR4 AURKB

8.41e-06201294ad2d25d84345fdd593065516a05c5c2b5429eac0
ToppCellBronchial-10x5prime-Stromal-Schwann-Schwann_nonmyelinating|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

GPR155 SARDH RALYL

5.81e-05116293b0a3c109c5f20ab699e53bf8ab3903d102f5f315
ToppCellCOVID-19_Severe-Neu_3|COVID-19_Severe / 5 Neutrophil clusters in COVID-19 patients

NUPR2 NPC1L1 RALYL

6.92e-051232934c20c025b6f19f075a13282288fc537e6e186217
ToppCellCOVID-19_Severe-Neu_3|World / 5 Neutrophil clusters in COVID-19 patients

NUPR2 NPC1L1 RALYL

7.09e-0512429354b42ffb161eece4ae308782e43a0e0dc360281e
ToppCellnormal_Lung-Myeloid_cells-Undetermined|normal_Lung / Location, Cell class and cell subclass

GPR155 NALCN HLA-DQB1

1.27e-0415129323b6cf9a36ad0e937f69c75921bddd305a9a526c
ToppCellnormal_Lymph_Node-Myeloid_cells-mo-Mac|Myeloid_cells / Location, Cell class and cell subclass

KCTD12 GPR155 TLR4

1.32e-041532935424494ea1f09542799045a875cc3eac13de5079
ToppCellBronchial-10x5prime-Stromal-Schwann|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

GPR155 SARDH RALYL

1.56e-04162293afffecc6c504930554aafc12c5bffa53e3c5b016
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PFKFB1 SHCBP1 RALYL

1.62e-041642936fb2136168f430babfeb81ca7e151ca7a8092ec4
ToppCellfacs-Lung-Endomucin-3m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NLRP1 SHCBP1 MEN1

1.68e-04166293a2ce44702a0cd5fa5872cac3302d3c451205feef
ToppCellfacs-Lung-Endomucin-3m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NLRP1 SHCBP1 MEN1

1.68e-041662930f641302a6b71c4badaaf20f51162bfc2386b167
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KCTD12 TLR4 AURKB

1.68e-04166293bb8135119dc37fdbba476599a56d368f422688dc
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KCTD12 NUPR2 SHCBP1

1.71e-04167293166b7b4ca0663cde6d88219ee0bcc1988d03dab8
ToppCell343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|343B / Donor, Lineage, Cell class and subclass (all cells)

KLC2 SHCBP1 AURKB

1.77e-04169293a949f547b53126a208819bade74a1ac9b2a36ea7
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PFKFB1 SHCBP1 AURKB

1.77e-04169293563c267edaade0e5df192ad953801ef9768d4270
ToppCell5'-Adult-SmallIntestine-Hematopoietic-B_cells-Cycling_B_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HLA-DQB1 SHCBP1 AURKB

1.77e-04169293a34aff9257ae9746226ee7af595c4678a4b0c896
ToppCell343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|343B / Donor, Lineage, Cell class and subclass (all cells)

KLC2 SHCBP1 AURKB

1.77e-04169293195d5cd60d646ac6d40a3321b2f739917e7aef14
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.4.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

C8B NALCN HLA-DQB1

1.80e-0417029379420950d5e4b5da9f52d2a8a8ce096ae44a5edf
ToppCelldroplet-Lung-nan-18m-Lymphocytic-Proliferating_NK|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHCBP1 AURKB CPNE7

1.86e-04172293e495efd25aec60b97ac2b5aa861651bd73174a17
ToppCell10x5'-lymph-node_spleen-Hematopoietic_progenitors-Cycling_pre-Myeloid-2|lymph-node_spleen / Manually curated celltypes from each tissue

KCTD12 SHCBP1 AURKB

1.90e-04173293783b8fa08b9d8f597f251793eae164151662f1f9
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Proliferating_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PFKFB1 SHCBP1 AURKB

1.90e-041732936c9ecf77d2fb0f89100fdd7e4e88f85598278bc7
ToppCell5'-Adult-LargeIntestine-Hematopoietic-B_cells-Cycling_B_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HLA-DQB1 SHCBP1 AURKB

1.90e-04173293b7e0193fd4983cb38d1bee441f608f73ee8743b9
ToppCelldroplet-Lung-18m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-proliferating_NK|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SHCBP1 AURKB CPNE7

2.00e-04176293b17317ac41d3215db55a38cbd3366c0947f7a2a3
ToppCell368C-Lymphocytic-CD4_T-cell-Proliferating_T_cell|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

NUPR2 SHCBP1 AURKB

2.03e-04177293844017225e9039d1bc621a9630a30c2e9a51b36d
ToppCell368C-Lymphocytic-CD4_T-cell-Proliferating_T_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

NUPR2 SHCBP1 AURKB

2.03e-0417729326c25d10aa511b64cc7db43a8deea7b5d31bca96
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NLRP1 C12orf56 SYNJ2

2.06e-041782935f779a66aa42d1d8e8af17b4a08d5dcc733efd4c
ToppCelldroplet-Lung-30m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2-17-52|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PFKFB1 FNTA SHCBP1

2.10e-04179293af03705a783e77f75c44fdfa793cfdccbf9dd91c
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SARDH PIGU NUPR2

2.10e-04179293e880c507f11ce75d104593a4ca29f0295f8125e8
ToppCellPBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

KCTD12 SHCBP1 TLR4

2.10e-04179293e1bfd553c043ebc070ccf8545d489ba16d9b2ef4
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-Myeloid-Macrophages|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KCTD12 HLA-DQB1 TLR4

2.13e-041802937af90f0e7ca001bf1fe5c860ee54c4cc8eb483bf
ToppCellAdult-Immune-T_lymphocyte-D122|Adult / Lineage, Cell type, age group and donor

GPR155 NLRP1 CPNE7

2.13e-0418029306c371d0f0c5a7b234dd143e98800e19af95a8b5
ToppCell3'-Pediatric_IBD-SmallIntestine-Hematopoietic-B_cells-Cycling_plasma_cell|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HLA-DQB1 SHCBP1 AURKB

2.13e-04180293ce2fc270f9d9110c2544083f61936b0b7d3b7eb3
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c11-MKI67-FOS|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PIGU AURKB CPNE7

2.17e-041812936873c1138b28c130637d06b64981ad11c262e85f
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Nonclassical_Monocyte|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

KCTD12 HLA-DQB1 TLR4

2.24e-0418329336b194e366a14ebc4df187bf31c902be3797bfcc
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

KCTD12 HLA-DQB1 TLR4

2.24e-04183293745271bfe15e94a58157cd97d771e610f964341b
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P5|Striatum / BrainAtlas - Mouse McCarroll V32

HNRNPC SHCBP1 AURKB

2.24e-04183293f20b0d71f857ac35868fd80531050ad8b6091716
ToppCellPND07-Epithelial-Epithelial_Airway-Neurosecretory-PNEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NALCN RALYL CPNE7

2.27e-041842933e5c68a99c10eb1ddc1048bea4aa9f6b8e2746ff
ToppCell343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SYNJ2 SHCBP1 AURKB

2.27e-041842936b2449ac65a2322aa0479fba0d89828f243aabbe
ToppCell343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SYNJ2 SHCBP1 AURKB

2.27e-04184293e90622b82fa7f16a1faaf7a4724c958f2d83341d
ToppCellPND07-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NALCN RALYL CPNE7

2.27e-041842931e2f0cec50475a1cf2973a5082826bbc60fc9a68
ToppCell10x5'-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-2|bone_marrow / Manually curated celltypes from each tissue

KCTD12 SHCBP1 AURKB

2.35e-04186293e82d5e7a976b9cfa2b4640c7a7cd1cfea19c4806
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-neuron_precursor-cycling_neuroblast|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHCBP1 RALYL AURKB

2.35e-041862934fe8e0bf74c7dbf73634cafdacad89020d2634d0
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.4.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

C8B NALCN HLA-DQB1

2.35e-04186293cb7df8da6478b96955f3ef1394a0655ec8061bba
ToppCell10x5'-GI_small-bowel-Lymphocytic_B-GC_B_(I)|GI_small-bowel / Manually curated celltypes from each tissue

C8B SHCBP1 AURKB

2.38e-04187293a92cade2a835f5fce8de1e14650af8cdd818c296
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KCTD12 NLRP1 C12orf56

2.46e-0418929312b6f1c3bf526b90e112374bf937701f645c5780
ToppCellASK454-Endothelial-Lymphatic|Endothelial / Donor, Lineage and Cell class of Lung cells from Dropseq

NLRP1 MCMDC2 CPNE7

2.46e-04189293316c857dec9383823e09f966bca62d52d933b141
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_CCL3+-Alveolar_macrophage_CCL3+_L.1.0.2.4|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

C8B HLA-DQB1 TLR4

2.46e-04189293a59025e82fabd9d60e2438dee85b2644478cc7c8
ToppCellBAL-Severe-Myeloid-TRAM-TRAM1-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

C8B NALCN HLA-DQB1

2.50e-041902930eef5a8bd88ef8a25a67d9dd522d9472fa4b3d2f
ToppCellCaecum-Dendritic_cell-cycling_DCs|Dendritic_cell / Region, Cell class and subclass

KCTD12 SHCBP1 AURKB

2.50e-0419029354463f6f1718f22704175bd034f134de3b55d2eb
ToppCellBAL-Severe-Myeloid-TRAM-TRAM1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

C8B NALCN HLA-DQB1

2.50e-041902932724e8f375d8d9f5f2a77444e0491af264babac5
ToppCell390C-Myeloid-Macrophage|390C / Donor, Lineage, Cell class and subclass (all cells)

KCTD12 C8B HLA-DQB1

2.50e-04190293f933d971f092c4e56e9f670a9205b688c8b1ca28
ToppCellBAL-Severe-Myeloid-TRAM-TRAM1-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

C8B NALCN HLA-DQB1

2.50e-0419029311fbd4e9f02750354b3aadf30edc991f8d4f8f41
ToppCellBAL-Severe-Myeloid-TRAM-TRAM1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

C8B NALCN HLA-DQB1

2.50e-04190293148d43dd72e2e22b2cd68e17fedae6bd98b32aee
ToppCell3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Myeloid-Macrophages|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KCTD12 HLA-DQB1 TLR4

2.54e-0419129394c7da03e5264f4d73bb507ce339a935d90279a0
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2|356C / Donor, Lineage, Cell class and subclass (all cells)

C8B SHCBP1 AURKB

2.54e-04191293a2c235a55094e4fd5273d764c9e2967116b48c23
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-Alveolar_macrophage_proliferating_L.1.0.7.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

C8B SHCBP1 AURKB

2.54e-04191293d6e158f16a183c9203c057192342e9b83e79bc89
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

C8B SHCBP1 AURKB

2.54e-041912937cb5c6f2cf27f3503d1b313e402a7410dfe6473e
ToppCellSevere_COVID-19-Myeloid-TRAM1|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

C8B NALCN HLA-DQB1

2.54e-04191293bd641aab36276dd952a7265ee79ba455b38d8e6b
ToppCell3'_v3-bone_marrow-Myeloid_Dendritic-Cycling_Dendritic|bone_marrow / Manually curated celltypes from each tissue

HLA-DQB1 SHCBP1 AURKB

2.54e-04191293aa9c0b1b90cdb7a95d4e6332819f82cae0a79ff9
ToppCellwk_20-22-Hematologic-Myeloid-Cycling_DC|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

HLA-DQB1 SHCBP1 AURKB

2.54e-041912931da569ebcfab4e1a95315430ae77a17a1f119263
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KCTD12 SHCBP1 RALYL

2.54e-041912937235a4d1601c88a2c8af571a2c04ab56d32f1b9a
ToppCell(3)_Macrophage_Dividing|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

C8B SHCBP1 AURKB

2.54e-04191293b42f0b89bb94fd43786ff50f1caeb3ebfbbb43fd
ToppCell5'-Adult-SmallIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KCTD12 HLA-DQB1 TLR4

2.58e-0419229322f335e6e75a694cdccafe189b5ee7815ef28c03
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PFKFB1 C12orf56 TLR4

2.58e-04192293935a4a36881a9fa4daa02cba96af07f6686ed8d6
ToppCellH1299-infected|H1299 / Cell line, Condition and Strain

NLRP1 AURKB CPNE7

2.58e-041922939cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KCTD12 NLRP1 SYNJ2

2.58e-0419229356b021c297a21dff357531f21e2464f85186106d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KCTD12 SHCBP1 RALYL

2.62e-04193293e7012f7b53971972299db34fa51ff51a4e4987fe
ToppCelldistal-Hematologic-IGSF21+_Dendritic-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KCTD12 GPR155 HLA-DQB1

2.62e-0419329348ce11778252ae2ef902b30816061b59a3c81695
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KCTD12 NLRP1 SYNJ2

2.62e-041932936a623acd1adad9a78eddc32ffedb16352ad3fdfa
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KCTD12 NLRP1 C12orf56

2.62e-041932930b328f725f6feba263783eaca60c142e80df90f3
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KCTD12 NLRP1 SYNJ2

2.62e-041932932e72309607902dabe3218888b22a77fe941f3570
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell-T_cells_proliferating-T_cells_proliferating_L.1.1.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SHCBP1 AURKB CPNE7

2.62e-04193293b835d28de9daeec5213172c96f62b332cda53bb5
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NLRP1 SEMA6A HLA-DQB1

2.66e-04194293cf9cf115dbbb9997f7c303ae07f42f3d80ff9a21
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KCTD12 SHCBP1 RALYL

2.66e-04194293be869e186386d03ebb670971dd24fa656b4b0edf
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KCTD12 HLA-DQB1 TLR4

2.66e-041942938e2819a9d0529f7b2de1a7c1190575175d6173ee
ToppCellMonocytes-C1QA+_Monocytes|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

KCTD12 HLA-DQB1 TLR4

2.66e-041942933e104e85574894c04791252d466d438fc809dde3
ToppCelltumor_Lymph_Node_/_Brain-T/NK_cells-Exhausted_CD8+_T|T/NK_cells / Location, Cell class and cell subclass

SARDH HLA-DQB1 CPNE7

2.66e-041942937b8fe5b702b99aac5bff7de8ac0b5cabb3235b56
ToppCell21-Trachea-Immune-Hematopoietic,_Macrophage|Trachea / Age, Tissue, Lineage and Cell class

KCTD12 HLA-DQB1 TLR4

2.66e-041942933c4ac5f91b10802990b84db3406f5e71f8ee8b74
ToppCell356C-Myeloid-Dendritic|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

HLA-DQB1 SHCBP1 AURKB

2.70e-04195293ba8b8831bd5f544f4e25f13949d04e164ecdcd12
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell-T_cells_proliferating|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SHCBP1 AURKB CPNE7

2.70e-0419529367670d16ddd5d5ab7bc2254df329f5a7b2581556
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

KCTD12 HLA-DQB1 TLR4

2.70e-041952933a30479857fc2805df92655c9599389559b1995d
ToppCell367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

KCTD12 GPR155 HLA-DQB1

2.70e-041952934008fa86b5166087a4b20f89ae07e1dfc87c855d
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HLA-DQB1 SHCBP1 AURKB

2.70e-04195293db1660ce74819cd816bdcfcae5efb3aad82cce66
ToppCell390C-Myeloid-Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

KCTD12 C8B HLA-DQB1

2.70e-04195293ba494be431916d43c1d480f65bed674c0722c710
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SHCBP1 AURKB CPNE7

2.70e-0419529323dc2f8a3a038195a31feee7e3a51094a7a7c23e
ToppCellTracheal-10x5prime-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NALCN HLA-DQB1 SHCBP1

2.70e-04195293c96755d2eb98112b703b5dbee9c88730ace7dcbf
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KCTD12 HLA-DQB1 TLR4

2.70e-04195293ec218ae03ebf8588996e86d6d9a8ea3cf71affaa
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW08-Myeloid|GW08 / Sample Type, Dataset, Time_group, and Cell type.

KCTD12 SHCBP1 TLR4

2.74e-0419629391a8c4798572d6c1f03cef5e8e5464ed0046c7cf
ToppCellVE-granulo1-|VE / Condition, Cell_class and T cell subcluster

KCTD12 HLA-DQB1 TLR4

2.74e-04196293ab3f2ce294c7e503d86254a195be0cf500a2c5e4
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW08-Myeloid-Microglia|GW08 / Sample Type, Dataset, Time_group, and Cell type.

KCTD12 SHCBP1 TLR4

2.74e-0419629389a0ccd0684777927d99d5fc5b7c498f3f124250
Diseasevitiligo (is_implicated_in)

NLRP1 HLA-DQB1 TLR4

1.12e-0621293DOID:12306 (is_implicated_in)
Diseaseuncharacterized protein C14orf93 measurement

C8B FBXW5

5.59e-064292EFO_0802190
DiseaseC-C motif chemokine 1 measurement

C8B HNRNPC

1.95e-057292EFO_0008041
Diseaseneurexophilin-1 measurement

C8B HNRNPC

2.60e-058292EFO_0008244
Diseasesulfatase-modifying factor 1 measurement

C8B FBXW5

2.60e-058292EFO_0802098
Diseasearthritis (is_implicated_in)

HLA-DQB1 TLR4

3.34e-059292DOID:848 (is_implicated_in)
Diseaseirritability measurement

USP4 PIGU TLR4

7.17e-0582293EFO_0009594
Diseaseubiquitin carboxyl-terminal hydrolase 25 measurement

HNRNPC HLA-DQB1

2.13e-0422292EFO_0021881
Diseasecholesterol:total lipids ratio, low density lipoprotein cholesterol measurement

HNRNPC HLA-DQB1 NPC1L1

3.79e-04144293EFO_0004611, EFO_0020943
Diseaselow density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

HNRNPC HLA-DQB1 NPC1L1

4.52e-04153293EFO_0004611, EFO_0020944
Diseasechronic hepatitis C virus infection

HLA-DQB1 MEN1

4.83e-0433292EFO_0004220
DiseaseIGA Glomerulonephritis

HLA-DQB1 AURKB

5.13e-0434292C0017661
Diseasecholesteryl ester 18:0 measurement

NLRP1 NPC1L1

5.76e-0436292EFO_0010343
DiseaseBehcet's disease (is_implicated_in)

HLA-DQB1 TLR4

5.76e-0436292DOID:13241 (is_implicated_in)
Diseasehepatocellular carcinoma

HNRNPC HLA-DQB1

7.47e-0441292EFO_0000182
Diseasepulmonary tuberculosis (is_implicated_in)

HLA-DQB1 TLR4

7.84e-0442292DOID:2957 (is_implicated_in)
Diseasediabetic retinopathy (is_implicated_in)

HLA-DQB1 TLR4

1.11e-0350292DOID:8947 (is_implicated_in)
Diseaseunipolar depression, sex interaction measurement

KCTD12 MEN1

1.15e-0351292EFO_0003761, EFO_0008343
Diseasephysical activity measurement

USP4 HLA-DQB1 TLR4

1.76e-03245293EFO_0008002
Diseaseendometriosis

SYNJ2 VEZT HNRNPC

1.91e-03252293EFO_0001065
Diseaseage at initiation of smoking

TLR4 CPNE7

1.92e-0366292EFO_0021784

Protein segments in the cluster

PeptideGeneStartEntry
YRREAVSYKNYEFFL

PFKFB1

81

P16118
YFNRDDVALENFFRY

FTHL17

41

Q9BXU8
YISYLGFRFYVDADR

COX10

391

Q12887
FDYDYYRDDFYNRLF

RALYL

126

Q86SE5
YNYCREDEEIYKEFF

MEN1

356

O00255
SFDLDYDFQRDYYDR

HNRNPC

121

P07910
FELYNEEYLEQRDLY

MCMDC2

641

Q4G0Z9
EYEFRDEYLFYRFLQ

GPR155

821

Q7Z3F1
RDEFLWREQFYRYYQ

FBXW5

41

Q969U6
EELYDCLDYYYLRDF

NUPR2

26

A6NF83
RKEYFYRYFTDERQA

NLRP1

486

Q9C000
LISDYFYAFLRREYY

PIGU

401

Q9H490
EEVEYYYRRALEIYA

KLC2

341

Q9H0B6
SYLLDYFLFLNRYFE

NPC1L1

881

Q9UHC9
RYIYNREEYARFDSD

HLA-DQB1

61

P01920
YYFEEVQRLRFEVYD

CPNE7

81

Q9UBL6
FLDRDGFLFRYILDY

KCTD12

81

Q96CX2
LEYSYGEYRDLFRDF

C8B

326

P07358
DFNYRIDLTYEEVFY

SYNJ2

726

O15056
IYSDKFRDVYDYFRA

FNTA

91

P49354
LLFYERFRAYQDYIL

SHCBP1

76

Q8NEM2
YAYRRLLADEYTFAF

SARDH

536

Q9UL12
AEYIRNNYREEFRYF

C12orf56

576

Q8IXR9
YNYFYDRRRIYLILE

AURKB

141

Q96GD4
YVLFYQRRDDEFYKT

USP4

916

Q13107
VDYGDYIYFFFREIA

SEMA6A

226

Q9H2E6
YIYFFFREIAVEYNT

SEMA6A

231

Q9H2E6
ELKRSYEFYRYFETQ

VEZT

391

Q9HBM0
EEFRLAYLDYYLDDI

TLR4

286

O00206
FRRQYDEFYLAEVAF

NALCN

411

Q8IZF0