Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glycerol kinase activity	GK GK2	4.62e-05	3	79	2	GO:0004370
GeneOntologyMolecularFunction	histone H3K9me/H3K9me2 demethylase activity	KDM3A KDM7A	1.53e-04	5	79	2	GO:0140683
Domain	Carb_kinase_FGGY_CS	GK GK2	5.29e-05	3	79	2	IPR018483
Domain	Glycerol_kin	GK GK2	1.05e-04	4	79	2	IPR005999
Domain	FGGY_KINASES_2	GK GK2	1.75e-04	5	79	2	PS00445
Domain	FGGY_KINASES_1	GK GK2	1.75e-04	5	79	2	PS00933
Domain	Carb_kinase_FGGY_C	GK GK2	1.75e-04	5	79	2	IPR018485
Domain	Syntrophin	SNTB1 SNTB2	1.75e-04	5	79	2	IPR015482
Domain	FGGY_C	GK GK2	2.62e-04	6	79	2	PF02782
Domain	Carb_kinase_FGGY_N	GK GK2	2.62e-04	6	79	2	IPR018484
Domain	Carb_kinase_FGGY	GK GK2	3.66e-04	7	79	2	IPR000577
Domain	FGGY_N	GK GK2	3.66e-04	7	79	2	PF00370
Domain	PH	IQSEC3 RASA1 DOK7 OBSCN SNTB1 SNTB2	1.15e-03	278	79	6	SM00233
Domain	PH_DOMAIN	IQSEC3 RASA1 DOK7 OBSCN SNTB1 SNTB2	1.18e-03	279	79	6	PS50003
Domain	PH_domain	IQSEC3 RASA1 DOK7 OBSCN SNTB1 SNTB2	1.20e-03	280	79	6	IPR001849
Domain	RasGAP	RASA1 IQGAP3	1.56e-03	14	79	2	SM00323
Domain	RasGAP_CS	RASA1 IQGAP3	1.56e-03	14	79	2	IPR023152
Domain	RasGAP	RASA1 IQGAP3	1.79e-03	15	79	2	PF00616
Domain	RAS_GTPASE_ACTIV_1	RASA1 IQGAP3	1.79e-03	15	79	2	PS00509
Domain	RAS_GTPASE_ACTIV_2	RASA1 IQGAP3	1.79e-03	15	79	2	PS50018
Domain	-	RASA1 IQGAP3	2.04e-03	16	79	2	1.10.506.10
Domain	-	JUN MAF	2.04e-03	16	79	2	1.10.880.10
Domain	PH_dom-like	IQSEC3 RASA1 DOK7 OBSCN MTMR1 SNTB1 SNTB2	2.16e-03	426	79	7	IPR011993
Domain	RasGAP_dom	RASA1 IQGAP3	2.59e-03	18	79	2	IPR001936
Domain	IQ	IQSEC3 OBSCN IQGAP3	3.39e-03	71	79	3	PF00612
Pubmed	SHARPIN regulates cell proliferation of cutaneous basal cell carcinoma via inactivation of the transcriptional factors GLI2 and c‑JUN.	JUN GLI2 SHARPIN	1.17e-08	3	80	3	32319607
Pubmed	Retrotransposition of glycerol kinase-related genes from the X chromosome to autosomes: functional and evolutionary aspects.	GK GK2 TCOF1	4.07e-07	7	80	3	10444329
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	EPN3 JUN SEPHS2 FAM89A ABCA2 EHBP1L1 MAP1S NRF1 ATP13A1 UBR4 OBSCN BIRC6 IQGAP3	1.37e-06	1105	80	13	35748872
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	ZNF787 HABP4 AKAP8 TOMM22 MRPL12 LEMD3 ATXN7 ATP13A1 SLC35E1 CXXC5 SLC25A11 HACD2 IQGAP3 SNTB2 PPP1R12C	1.43e-06	1497	80	15	31527615
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	IPO9 AKAP8 TOMM22 TCOF1 LEMD3 ATP13A1 UBR4 SLC35E1 HACD2 IQGAP3 QSOX2 YIPF3	1.61e-06	942	80	12	31073040
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	CDX2 IPO9 TCOF1 LEMD3 KMT5A GLI2 MPZL1 SLC35E1 AGPS QSOX2 YIPF3 PRNP MAF	3.49e-06	1203	80	13	29180619
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	ZNF787 EHBP1L1 IPO9 LEMD3 KMT5A UBR4 MTMR1 DGKI SIK3 PRNP	4.13e-06	689	80	10	36543142
Pubmed	Proteomic discovery of Max as a novel interacting partner of C/EBPalpha: a Myc/Max/Mad link.	JUN SLC25A11 MAF	4.19e-06	14	80	3	17082780
Pubmed	Preventing polyglutamine-induced activation of c-Jun delays neuronal dysfunction in a mouse model of SCA7 retinopathy.	JUN ATXN7	5.23e-06	2	80	2	17189700
Pubmed	Prognostic role of tumour-infiltrating lymphocytes and macrophages in relation to MSI, CDX2 and BRAF status: a population-based study of metastatic colorectal cancer patients.	CDX2 BRAF	5.23e-06	2	80	2	34671130
Pubmed	c-Jun inhibits NF-E2 transcriptional activity in association with p18/maf in Friend erythroleukemia cells.	JUN MAF	5.23e-06	2	80	2	9047395
Pubmed	Possible role of Cdx2 in the serrated pathway of colorectal cancer characterized by BRAF mutation, high-level CpG Island methylator phenotype and mismatch repair-deficiency.	CDX2 BRAF	5.23e-06	2	80	2	24166180
Pubmed	BRAFV600E cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis.	CDX2 BRAF	5.23e-06	2	80	2	28072391
Pubmed	Glycerol kinase 2 is essential for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during mouse spermatogenesis.	GK GK2	5.23e-06	2	80	2	30662012
Pubmed	Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.	ABCA2 EFEMP1 ATXN7 ADAM33 PPP1R12C	8.10e-06	118	80	5	21078624
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	EPN3 ZNF787 MRPL12 UBR4 SHARPIN ASPSCR1 BIRC6 IQGAP3 QSOX2	1.05e-05	604	80	9	38803224
Pubmed	Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs.	SOX1 CDX2 GATA6	1.11e-05	19	80	3	35988542
Pubmed	Tagging genes with cassette-exchange sites.	MRPL12 LEMD3 GLI2 UBR4 KDM7A BIRC6 SNTB2	1.26e-05	335	80	7	15741177
Pubmed	NotI flanking sequences: a tool for gene discovery and verification of the human genome.	RFXAP SNTB1 SNTB2	1.51e-05	21	80	3	12136098
Pubmed	PIK3CA mutation occurs in nasopharyngeal carcinoma but does not significantly influence the disease-specific survival.	BRAF RASA1	1.57e-05	3	80	2	19012001
Pubmed	Glycerol kinase-like proteins cooperate with Pld6 in regulating sperm mitochondrial sheath formation and male fertility.	GK GK2	1.57e-05	3	80	2	28852571
Pubmed	NRF-1, and AP-1 regulate the promoter of the human calpain small subunit 1 (CAPNS1) gene.	JUN NRF1	1.57e-05	3	80	2	18234454
Pubmed	Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun.	JUN MAF	1.57e-05	3	80	2	8108109
Pubmed	Loss of SATB2 and CDX2 expression is associated with DNA mismatch repair protein deficiency and BRAF mutation in colorectal cancer.	CDX2 BRAF	1.57e-05	3	80	2	37583001
Pubmed	Differential expression of syntrophins and analysis of alternatively spliced dystrophin transcripts in the mouse brain.	SNTB1 SNTB2	1.57e-05	3	80	2	9182949
Pubmed	Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24.	SNTB1 SNTB2	1.57e-05	3	80	2	8183929
Pubmed	Identification of several novel non-p.R132 IDH1 variants in thyroid carcinomas.	BRAF RASA1	1.57e-05	3	80	2	20702649
Pubmed	Differential targeting of components of the dystrophin complex to the postsynaptic membrane.	SNTB1 SNTB2	1.57e-05	3	80	2	11168526
Pubmed	c-Jun phosphorylated by JNK is required for protecting Gli2 from proteasomal-ubiquitin degradation by PGE2-JNK signaling axis.	JUN GLI2	1.57e-05	3	80	2	36581088
Pubmed	Mice lacking α-, β1- and β2-syntrophins exhibit diminished function and reduced dystrophin expression in both cardiac and skeletal muscle.	SNTB1 SNTB2	1.57e-05	3	80	2	30256963
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	TRPC4AP EHBP1L1 IPO9 MRPL12 ATXN7 UBR4 DSG4 SIK3 SNTB2	1.62e-05	638	80	9	31182584
Pubmed	Embryo model completes gastrulation to neurulation and organogenesis.	SOX1 CDX2 GATA6	1.75e-05	22	80	3	36007540
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	CARM1 EFEMP1 TOMM22 MRPL12 LEMD3 ATP13A1 EID2 HACD2 SIK3 AGPS HIBADH QSOX2 PRNP	2.56e-05	1451	80	13	30550785
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	GK2 AKAP8 MSI1 HACD2 AGPS HIBADH BIRC6 QSOX2 SNTB2	2.86e-05	686	80	9	28380382
Pubmed	Transcription factors GATA4 and HNF4A control distinct aspects of intestinal homeostasis in conjunction with transcription factor CDX2.	CDX2 GATA6	3.13e-05	4	80	2	25488664
Pubmed	Sox1 maintains the undifferentiated state of cortical neural progenitor cells via the suppression of Prox1-mediated cell cycle exit and neurogenesis.	SOX1 MSI1	3.13e-05	4	80	2	21280160
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	CARM1 AKAP8 MAP1S TOMM22 UBR4 SLC25A11 AGPS BIRC6 IQGAP3	3.49e-05	704	80	9	29955894
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	ZNF787 JUN HIC1 CDX2 GLI2 GATA6 ZBTB12 MAF	3.68e-05	544	80	8	28473536
Pubmed	A Retinoic Acid-Hedgehog Cascade Coordinates Mesoderm-Inducing Signals and Endoderm Competence during Lung Specification.	CDX2 GLI2 GATA6	4.10e-05	29	80	3	27320915
Pubmed	The glycerol kinase gene family: structure of the Xp gene, and related intronless retroposons.	GK GK2	5.20e-05	5	80	2	7987308
Pubmed	Assembly of multiple dystrobrevin-containing complexes in the kidney.	SNTB1 SNTB2	5.20e-05	5	80	2	10893187
Pubmed	Differential assembly of inwardly rectifying K+ channel subunits, Kir4.1 and Kir5.1, in brain astrocytes.	SNTB1 SNTB2	5.20e-05	5	80	2	15310750
Pubmed	Degree of Tissue Differentiation Dictates Susceptibility to BRAF-Driven Colorectal Cancer.	CDX2 BRAF	5.20e-05	5	80	2	29281831
Pubmed	The microtubule associated protein syntabulin is required for glucose-stimulated and cAMP-potentiated insulin secretion.	SOX1 MSI1	5.20e-05	5	80	2	22975310
Pubmed	Differential association of syntrophin pairs with the dystrophin complex.	SNTB1 SNTB2	5.20e-05	5	80	2	9214383
Pubmed	Mouse TCOF1 is expressed widely, has motifs conserved in nucleolar phosphoproteins, and maps to chromosome 18.	GK TCOF1	5.20e-05	5	80	2	9299440
Pubmed	The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.	CDX2 TMEM121B MAF	6.08e-05	33	80	3	19336002
Pubmed	Sequence analysis, identification of evolutionary conserved motifs and expression analysis of murine tcof1 provide further evidence for a potential function for the gene and its human homologue, TCOF1.	GK TCOF1	7.79e-05	6	80	2	9158147
Pubmed	Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation.	JUN NRF1	7.79e-05	6	80	2	12490281
Pubmed	Progression of the pluripotent epiblast depends upon the NMD factor UPF2.	CDX2 GATA6	7.79e-05	6	80	2	36255229
Pubmed	The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives.	SNTB1 SNTB2	7.79e-05	6	80	2	8576247
Pubmed	The primitive endoderm supports lineage plasticity to enable regulative development.	CDX2 GATA6	7.79e-05	6	80	2	38917790
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	CARM1 TRPC4AP AKAP8 TCOF1 LEMD3 UBR4 MTMR1 QSOX2 SNTB1 SNTB2	7.92e-05	974	80	10	28675297
Pubmed	Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain.	BRAF PTBP2 MTMR1	1.01e-04	39	80	3	22802532
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	JUN CDX2 MRPL12 LEMD3 ATP13A1 MPZL1 SLC35E1 QSOX2 ATPAF1 YIPF3	1.04e-04	1007	80	10	34597346
Pubmed	Global chromatin architecture reflects pluripotency and lineage commitment in the early mouse embryo.	CDX2 GATA6	1.09e-04	7	80	2	20479880
Pubmed	FGF4 is a limiting factor controlling the proportions of primitive endoderm and epiblast in the ICM of the mouse blastocyst.	CDX2 GATA6	1.09e-04	7	80	2	24063807
Pubmed	Early developmental plasticity enables the induction of an intermediate extraembryonic cell state.	CDX2 GATA6	1.09e-04	7	80	2	36332016
Pubmed	FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine.	CDX2 GLI2	1.09e-04	7	80	2	19049965
Pubmed	Two distinct sources for a population of maturing axial progenitors.	SOX1 CDX2	1.09e-04	7	80	2	17611225
Pubmed	The chromatin modifier Satb1 regulates cell fate through Fgf signalling in the early mouse embryo.	CDX2 GATA6	1.09e-04	7	80	2	28289135
Pubmed	Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions.	SNTB1 SNTB2	1.09e-04	7	80	2	11352924
Pubmed	Establishment of 3D chromatin structure after fertilization and the metabolic switch at the morula-to-blastocyst transition require CTCF.	CDX2 GATA6	1.09e-04	7	80	2	36260992
Pubmed	Proliferation of murine midbrain neural stem cells depends upon an endogenous sonic hedgehog (Shh) source.	SOX1 MSI1	1.45e-04	8	80	2	23776550
Pubmed	Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins.	SNTB1 SNTB2	1.45e-04	8	80	2	9412493
Pubmed	CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development.	CARM1 CDX2	1.45e-04	8	80	2	30550788
Pubmed	Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis.	CDX2 GATA6	1.45e-04	8	80	2	26199412
Pubmed	Spatacsin regulates directionality of lysosome trafficking by promoting the degradation of its partner AP5Z1.	UBR4 SPG11	1.45e-04	8	80	2	37871017
Pubmed	Gata6, Nanog and Erk signaling control cell fate in the inner cell mass through a tristable regulatory network.	CDX2 GATA6	1.45e-04	8	80	2	25209243
Pubmed	Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction.	SNTB1 SNTB2	1.45e-04	8	80	2	16533813
Pubmed	Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.	CARM1 KDM3A CDX2	1.45e-04	44	80	3	24183668
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	AKAP8 TCOF1 MRPL12 LEMD3 ATP13A1 UBR4 MTMR1 SPG11 SIK3 SNTB1 ATPAF1 SNTB2	1.46e-04	1487	80	12	33957083
Pubmed	Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.	ADPRS TOMM22 TCOF1 OBSCN SLC25A11 AGPS HIBADH ATPAF1 YIPF3	1.59e-04	859	80	9	31536960
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	ZNF787 EFEMP1 MAP1S TCOF1 MRPL12 UBR4 MPZL1 AGPS BIRC6 QSOX2 ATPAF1	1.84e-04	1297	80	11	33545068
Pubmed	Gli3 null mice display glandular overgrowth of the developing stomach.	CDX2 GLI2	1.86e-04	9	80	2	16247775
Pubmed	Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning.	SOX1 GLI2	1.86e-04	9	80	2	23249739
Pubmed	Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst.	CDX2 GATA6	1.86e-04	9	80	2	18725515
Pubmed	Stress-inducible phosphoprotein 1 has unique cochaperone activity during development and regulates cellular response to ischemia via the prion protein.	CDX2 PRNP	1.86e-04	9	80	2	23729591
Pubmed	H3K27me3 at pericentromeric heterochromatin is a defining feature of the early mouse blastocyst.	CDX2 GATA6	1.86e-04	9	80	2	35974030
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	KDM3A KMT5A KDM7A	2.00e-04	49	80	3	34368113
Pubmed	Regulation of c-Maf and αA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling.	JUN MAF	2.32e-04	10	80	2	26719333
Pubmed	Disorganized epithelial polarity and excess trophectoderm cell fate in preimplantation embryos lacking E-cadherin.	CDX2 GATA6	2.32e-04	10	80	2	20826529
Pubmed	Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks.	GLI2 MAF	2.32e-04	10	80	2	33006313
Pubmed	CNOT3-Dependent mRNA Deadenylation Safeguards the Pluripotent State.	CDX2 GATA6	2.32e-04	10	80	2	27746116
Pubmed	Onecut Factors and Pou2f2 Regulate the Distribution of V2 Interneurons in the Mouse Developing Spinal Cord.	SOX1 MAF	2.32e-04	10	80	2	31231191
Pubmed	Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway.	CDX2 GATA6	2.32e-04	10	80	2	16678776
Pubmed	Lineage Establishment and Progression within the Inner Cell Mass of the Mouse Blastocyst Requires FGFR1 and FGFR2.	CDX2 GATA6	2.32e-04	10	80	2	28552559
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	JUN IPO9 UBR4 SLC25A11 AGPS HIBADH BIRC6	2.34e-04	534	80	7	35032548
Pubmed	MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.	CDX2 GATA6	2.84e-04	11	80	2	37012455
Pubmed	Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin.	SNTB1 SNTB2	2.84e-04	11	80	2	10995443
Pubmed	Endogenous retroviruses shape pluripotency specification in mouse embryos.	CARM1 CDX2	2.84e-04	11	80	2	38266080
Pubmed	Hacd2 deficiency in mice leads to an early and lethal mitochondrial disease.	NRF1 HACD2	2.84e-04	11	80	2	36693621
Pubmed	Overlapping peri-implantation phenotypes of ZNHIT1 and ZNHIT2 despite distinct functions during early mouse development†.	CDX2 GATA6	2.84e-04	11	80	2	39194072
Pubmed	gamma-Syntrophin scaffolding is spatially and functionally distinct from that of the alpha/beta syntrophins.	SNTB1 SNTB2	2.84e-04	11	80	2	16857187
Pubmed	Xist/Tsix expression dynamics during mouse peri-implantation development revealed by whole-mount 3D RNA-FISH.	CDX2 GATA6	2.84e-04	11	80	2	30842444
Pubmed	GATA4 Controls Epithelial Morphogenesis in the Developing Stomach to Promote Establishment of Glandular Columnar Epithelium.	CDX2 GATA6	2.84e-04	11	80	2	34111600
Pubmed	Fibroblast growth factor receptor 1 (Fgfr1) is not essential for lens fiber differentiation in mice.	SOX1 MAF	2.84e-04	11	80	2	16446698
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	AKAP8 LEMD3 ATP13A1 MPZL1 SLC35E1 SPG11 BIRC6 YIPF3	2.86e-04	733	80	8	34672954
Pubmed	ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.	TOMM22 LEMD3 ATP13A1 MPZL1 SLC35E1 SLC25A11 AGPS BIRC6 YIPF3	3.39e-04	952	80	9	38569033
Pubmed	Large-scale concatenation cDNA sequencing.	CARM1 TRPC4AP IPO9 UBR4 CXXC5 SLC25A11 HACD2	3.39e-04	568	80	7	9110174
Cytoband	19p13.11	MAP1S ATP13A1 SLC35E1	2.90e-04	73	80	3	19p13.11
GeneFamily	Glycerol kinases	GK GK2	1.35e-04	6	55	2	568
Coexpression	NUYTTEN_NIPP1_TARGETS_DN	EPN3 SEPHS2 FAM89A TRPC4AP EHBP1L1 GK KMT5A DOK7 SLC35E1 CXXC5 ATPAF1 SNTB2	9.39e-06	845	80	12	M18090
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MAP1S LEMD3 C11orf68 MSI1 PPP1R14B QSOX2	6.35e-07	170	80	6	b1a16600754e0c12f7d39c9221f1b03135833f16
ToppCell	PBMC-Mild-cDC_5\|Mild / Compartment, Disease Groups and Clusters	ZNF787 HIC1 SLC35E1 CXXC5 CHST2 PPP1R14B	1.11e-06	187	80	6	0afef5baf3752314dbfb024790347d5e51f9b84b
Disease	glycerol kinase deficiency (implicated_via_orthology)	GK GK2	2.17e-05	3	80	2	DOID:0060363 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	KDM3A JUN HIC1 EFEMP1 AKAP8 BRAF UBR4 OBSCN ADAM33 MSI1 SIK3	1.49e-04	1074	80	11	C0006142
Disease	Barrett's esophagus (is_marker_for)	CDX2 GATA6	3.93e-04	11	80	2	DOID:9206 (is_marker_for)
Disease	cholesterol:total lipids ratio, low density lipoprotein cholesterol measurement	EHBP1L1 DOK7 SPG11 SIK3	6.45e-04	144	80	4	EFO_0004611, EFO_0020943
Disease	lysophosphatidylcholine measurement	DOK7 GATA6 MAF	6.47e-04	62	80	3	EFO_0010224
Disease	platelet component distribution width	HABP4 NRF1 RMI2 ADAM33 SLC25A11 CHST2 CHKB MAF	1.01e-03	755	80	8	EFO_0007984
Disease	platelet crit	HABP4 HIC1 NRF1 ATP13A1 RMI2 CXXC5 SLC25A11 KDM7A CHST2	1.09e-03	952	80	9	EFO_0007985
Disease	Noonan-Like Syndrome With Loose Anagen Hair	BRAF RASA1	1.20e-03	19	80	2	C3501846
Disease	Costello syndrome (disorder)	BRAF RASA1	1.20e-03	19	80	2	C0587248
Disease	Noonan syndrome-like disorder with loose anagen hair	BRAF RASA1	1.20e-03	19	80	2	C1843181
Disease	Cardio-facio-cutaneous syndrome	BRAF RASA1	1.20e-03	19	80	2	C1275081
Disease	colorectal adenoma (is_marker_for)	JUN SEPHS2	1.34e-03	20	80	2	DOID:0050860 (is_marker_for)
Disease	level of Phosphatidylinositol (18:0_18:2) in blood serum	DOK7 SIK3	1.47e-03	21	80	2	OBA_2045156
Disease	muscular dystrophy (implicated_via_orthology)	SNTB1 SNTB2	1.47e-03	21	80	2	DOID:9884 (implicated_via_orthology)
Disease	LEOPARD Syndrome	BRAF RASA1	1.62e-03	22	80	2	C0175704
Disease	phosphatidylserines measurement	DOK7 ASPSCR1	1.77e-03	23	80	2	EFO_0020049
Disease	vital capacity	HIC1 EFEMP1 BRAF KMT5A DOK7 ASPSCR1 AGPS HIBADH QSOX2 MAF	1.84e-03	1236	80	10	EFO_0004312
Disease	Noonan Syndrome	BRAF RASA1	1.93e-03	24	80	2	C0028326
Disease	eosinophil count	SEPHS2 TMEM121B KMT5A C11orf68 NFKBIL1 RMI2 SLC35E1 SHARPIN SIK3 CHKB MAF	2.21e-03	1488	80	11	EFO_0004842
Disease	Pigmented Basal Cell Carcinoma	RASA1 GLI2	2.62e-03	28	80	2	C1368275

Protein segments in the cluster

Peptide	Gene	Start	Entry
GDMEPEAGAGAGAAA	BRAF	21	P15056
AVAHGLNGGSPAAAM	CDX2	91	Q99626
MAAPAGGGGSAVSVL	ASPSCR1	1	Q9BZE9
MSAAGAGAGVEAGFS	ANKRD10	1	Q9NXR5
GRKMAAAAAAASGPG	BIRC6	26	Q9NR09
AKANDGGLAAGAPAM	AKAP8	61	O43823
MAAAAAVGNAVPCGA	ATP13A1	1	Q9HD20
GDGSPMANGAGAVVH	EPN3	261	Q9H201
AESGGCVMAAATGHP	ADAM33	366	Q9BZ11
MAAEATAVAGSGAVG	CHKB	1	Q9Y259
MDRPAAAAAAGCEGG	MTMR1	1	Q13613
GVAGAAVAGPSGDMA	RASA1	101	P20936
MAAAGAAVARSPGIG	QSOX2	1	Q6ZRP7
VAAAGPAAAAAAGMG	LEMD3	76	Q9Y2U8
MAGAAAAVAAGAAAG	KDM7A	1	Q6ZMT4
MAAVAGSGAAAAPSS	MAP1S	1	Q66K74
GGSGEEMGPAAAVVS	MAF	151	O75444
MGEGGAAAALVAAAA	KMT5A	1	Q9NQR1
KMHAVGGAAGAAGAL	HIC1	611	Q14526
GMVAPAVASVAGGSG	JUN	141	P05412
MAAAAAAVGPGAGGA	CARM1	1	Q86X55
AVGLMAAGAAGASGA	DSG4	741	Q86SJ6
MKGALGSPVAAAGAA	HABP4	1	Q5JVS0
LAAAGPVGMAAAAAV	NRF1	71	Q16656
PDAGAMGAAAAEGQA	EHBP1L1	1301	Q8N3D4
AMEAVAAGVDGAGPE	GLI2	1036	P10070
GGGDPEAMAAALVAR	NFKBIL1	306	Q9UBC1
MAASAGAGAVIAAPD	MPZL1	1	O95297
GGGMEDSVVAAAAVA	IQSEC3	216	Q9UPP2
GPMAAAAAAAAVVRG	MSI1	271	O43347
EDGGPGAASTSAAAM	ATXN7	61	O15265
AGAGLPDMEAVAGAE	CXXC5	186	Q7LFL8
APDAFDIVAMAAGGA	IQGAP3	1186	Q86VI3
MAATASAGAGGIDGK	SLC25A11	1	Q02978
DMAGSCVDAVAGGPA	OBSCN	801	Q5VST9
MANGAAREPGGYAAA	GATA6	271	Q92908
AAVGGEAASKPAGSM	KDM3A	796	Q9Y4C1
ALGAAMAAGAAEGVS	GK2	456	Q14410
AAAGAGAMNPSSSAG	DGKI	46	O75912
MAAVVVAAAGGAGPA	ATPAF1	1	Q5TC12
MAAVAATAAAKGNGG	HACD2	1	Q6Y1H2
TALGAAMAAGAAEGV	GK	461	P32189
AANGTGAGAVMGPNA	ABCA2	366	Q9BZC7
GAGAVMGPNATAEEG	ABCA2	371	Q9BZC7
MAAAAMAAAAGGGAG	ADPRS	1	Q9NX46
MAAAAGGGAGAARSL	ADPRS	6	Q9NX46
EAGEGAMAAARGGPV	EID2	41	Q8N6I1
MAAAAAAGAASGLPG	IPO9	1	Q96P70
PAAAQAAGEAMVGAS	DOK7	301	Q18PE1
GGSVAAAAAAMGAAL	FTCD	356	O95954
AAAAAMGAALGSMVG	FTCD	361	O95954
GGFVASAAAVAGPEM	EFEMP1	116	Q12805
MAVAAAAAAAGPAGA	SNTB1	1	Q13884
MAAAADSFSGGPAGV	RMI2	1	Q96E14
MSGEDGPAAGPGAAA	PPP1R12C	1	Q9BZL4
MAAAPVAAGSGAGRG	TRPC4AP	1	Q8TEL6
AAAAAAAAAGRVGMP	PTBP2	316	Q9UKA9
AAAAGRVGMPGVSAG	PTBP2	321	Q9UKA9
SMTAADFGGGAAAGA	TMEM121B	131	Q9BXQ6
AFGAAAKPGMVSAGQ	TCOF1	181	Q13428
MSGARAAPGAAGNGA	FAM89A	1	Q96GI7
VAGPGDARAAGMVAI	SSTR4	36	P31391
MAAAAASGAGGAAGA	SIK3	1	Q9Y2K2
MAPPAGGAAAAASDL	SHARPIN	1	Q9H0F6
MEAQGVAEGAGPGAA	RFXAP	1	O00287
MAAAAVGAGHGAGGP	SLC35E1	1	Q96K37
AAVAMGVGVGVGAAA	SOX1	151	O00570
MADSGTAGGAALAAP	PPP1R14B	1	Q96C90
GGVMSGAVPAAAAQE	MRPL12	101	P52815
GAVFMDAPVSGGVGA	HIBADH	151	P31937
MAEAAAAAGGTGLGA	AGPS	1	O00116
AAVGAAPAAAAGMAG	CHST2	131	Q9Y4C5
MAAAAAAAVAGVGRG	C11orf68	1	Q9H3H3
MAAEEGVASAASAGG	SPG11	1	Q96JI7
GEAMAAAEGSSGPAG	SEPHS2	11	Q99611
EAAAVAMAARGAGGS	ZBTB12	296	Q9Y330
LAGGVVGAGMAAAAL	RNF112	561	Q9ULX5
VGAGMAAAALAAEAG	RNF112	566	Q9ULX5
AAEAGMVAAGAAVGA	RNF112	576	Q9ULX5
MVAAGAAVGATGAAV	RNF112	581	Q9ULX5
HMAGAAAAGAVVGGL	PRNP	111	P04156
MAAAVAAAGAGEPQS	TOMM22	1	Q9NS69
MATTAAPAGGARNGA	YIPF3	1	Q9GZM5
MRVAAATAAAGAGPA	SNTB2	1	Q13425
MATSGGEEAAAAAPA	UBR4	1	Q5T4S7
VGAPGEGAAAAAAMA	ZNF787	246	Q6DD87
EGAAAAAAMAGAGAK	ZNF787	251	Q6DD87
AAAMAGAGAKAAGPR	ZNF787	256	Q6DD87
MGDFAAAAAGGVVPG	LRFN2	726	Q9ULH4