Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nicotinic acid receptor activity	HCAR3 HCAR2	1.18e-05	2	69	2	GO:0070553
GeneOntologyMolecularFunction	glycosylceramide flippase activity	ATP10A ATP10D	3.52e-05	3	69	2	GO:0140351
GeneOntologyMolecularFunction	ATPase-coupled intramembrane lipid transporter activity	ATP8B3 ATP10A ATP10D	1.22e-04	28	69	3	GO:0140326
GeneOntologyMolecularFunction	lipid transporter activity	ATP8B3 SLC22A10 SLC22A11 ATP10A ATP10D	5.85e-04	196	69	5	GO:0005319
GeneOntologyMolecularFunction	intramembrane lipid transporter activity	ATP8B3 ATP10A ATP10D	7.30e-04	51	69	3	GO:0140303
GeneOntologyMolecularFunction	G protein-coupled receptor activity	HCAR3 OR2T29 HCAR2 GPER1 OR10A4 OR2T5 OR2J2 GABBR2 OR8G2P SORCS1	8.73e-04	884	69	10	GO:0004930
GeneOntologyCellularComponent	DNA recombinase complex	RAG1 RAG2	1.04e-05	2	68	2	GO:0097519
GeneOntologyCellularComponent	phospholipid-translocating ATPase complex	ATP8B3 ATP10A ATP10D	1.17e-05	14	68	3	GO:1990531
HumanPheno	Protracted diarrhea	RAG1 RAG2 MYO5B	1.44e-05	13	20	3	HP:0004385
HumanPheno	Purulent rhinitis	RAG1 RAG2	1.46e-05	2	20	2	HP:0040334
Domain	Hydrolase_3	ATP8B3 ATP10A ATP10D	5.68e-06	10	69	3	PF08282
Domain	HCAR2/3_rcpt	HCAR3 HCAR2	1.35e-05	2	69	2	IPR028017
Domain	P_typ_ATPase_c	ATP8B3 ATP10A ATP10D	1.71e-05	14	69	3	IPR032630
Domain	P-type_ATPase_N	ATP8B3 ATP10A ATP10D	1.71e-05	14	69	3	IPR032631
Domain	P-type_ATPase_IV	ATP8B3 ATP10A ATP10D	1.71e-05	14	69	3	IPR006539
Domain	PhoLip_ATPase_C	ATP8B3 ATP10A ATP10D	1.71e-05	14	69	3	PF16212
Domain	PhoLip_ATPase_N	ATP8B3 ATP10A ATP10D	1.71e-05	14	69	3	PF16209
Domain	Apc4_WD40_dom	WDHD1 WDR17 ANAPC4	5.26e-05	20	69	3	IPR024977
Domain	ANAPC4_WD40	WDHD1 WDR17 ANAPC4	5.26e-05	20	69	3	PF12894
Domain	WD40_repeat_dom	WDR93 WDHD1 APAF1 ARHGEF17 WDR17 EML3 ANAPC4	1.11e-04	297	69	7	IPR017986
Domain	-	ATP8B3 ATP10A ATP10D	2.22e-04	32	69	3	3.40.1110.10
Domain	-	ATP8B3 ATP10A ATP10D	2.22e-04	32	69	3	2.70.150.10
Domain	-	WDR93 WDHD1 APAF1 ARHGEF17 WDR17 EML3 ANAPC4	2.25e-04	333	69	7	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	WDR93 WDHD1 APAF1 ARHGEF17 WDR17 EML3 ANAPC4	2.33e-04	335	69	7	IPR015943
Domain	ATPase_P-typ_cyto_domN	ATP8B3 ATP10A ATP10D	2.90e-04	35	69	3	IPR023299
Domain	P_typ_ATPase	ATP8B3 ATP10A ATP10D	3.16e-04	36	69	3	IPR001757
Domain	ATPase_P-typ_P_site	ATP8B3 ATP10A ATP10D	3.16e-04	36	69	3	IPR018303
Domain	ATPASE_E1_E2	ATP8B3 ATP10A ATP10D	3.16e-04	36	69	3	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP8B3 ATP10A ATP10D	3.43e-04	37	69	3	IPR008250
Domain	E1-E2_ATPase	ATP8B3 ATP10A ATP10D	3.43e-04	37	69	3	PF00122
Domain	FERM-adjacent	FARP1 FARP2	1.02e-03	13	69	2	IPR014847
Domain	FA	FARP1 FARP2	1.02e-03	13	69	2	SM01195
Domain	FA	FARP1 FARP2	1.02e-03	13	69	2	PF08736
Domain	DH_1	FARP1 ARHGEF17 FARP2	1.64e-03	63	69	3	PS00741
Domain	-	ATP8B3 ATP10A ATP10D	1.71e-03	64	69	3	3.40.50.1000
Domain	RhoGEF	FARP1 ARHGEF17 FARP2	2.04e-03	68	69	3	SM00325
Domain	RhoGEF	FARP1 ARHGEF17 FARP2	2.21e-03	70	69	3	PF00621
Domain	DH_2	FARP1 ARHGEF17 FARP2	2.21e-03	70	69	3	PS50010
Domain	DH-domain	FARP1 ARHGEF17 FARP2	2.30e-03	71	69	3	IPR000219
Domain	-	FARP1 ARHGEF17 FARP2	2.30e-03	71	69	3	1.20.900.10
Domain	Ez/rad/moesin-like	FARP1 FARP2	2.70e-03	21	69	2	IPR000798
Domain	HAD-like_dom	ATP8B3 ATP10A ATP10D	3.12e-03	79	69	3	IPR023214
Domain	GPCR_Rhodpsn_7TM	HCAR3 OR2T29 HCAR2 GPER1 OR10A4 OR2T5 OR2J2 OR8G2P	3.20e-03	670	69	8	IPR017452
Domain	7tm_1	HCAR3 OR2T29 HCAR2 GPER1 OR10A4 OR2T5 OR2J2 OR8G2P	3.41e-03	677	69	8	PF00001
Domain	FERM_CS	FARP1 FARP2	3.52e-03	24	69	2	IPR019747
Domain	WD_REPEATS_1	WDR93 WDHD1 APAF1 WDR17 EML3	3.65e-03	278	69	5	PS00678
Domain	G_PROTEIN_RECEP_F1_1	HCAR3 OR2T29 HCAR2 GPER1 OR10A4 OR2T5 OR2J2 OR8G2P	3.66e-03	685	69	8	PS00237
Domain	WD_REPEATS_2	WDR93 WDHD1 APAF1 WDR17 EML3	3.70e-03	279	69	5	PS50082
Domain	WD_REPEATS_REGION	WDR93 WDHD1 APAF1 WDR17 EML3	3.70e-03	279	69	5	PS50294
Domain	G_PROTEIN_RECEP_F1_2	HCAR3 OR2T29 HCAR2 GPER1 OR10A4 OR2T5 OR2J2 OR8G2P	3.86e-03	691	69	8	PS50262
Domain	GPCR_Rhodpsn	HCAR3 OR2T29 HCAR2 GPER1 OR10A4 OR2T5 OR2J2 OR8G2P	3.89e-03	692	69	8	IPR000276
Domain	FERM_C	FARP1 FARP2	4.13e-03	26	69	2	PF09380
Domain	FERM_C	FARP1 FARP2	4.45e-03	27	69	2	SM01196
Domain	FERM_PH-like_C	FARP1 FARP2	4.45e-03	27	69	2	IPR018980
Domain	FERM_N	FARP1 FARP2	6.60e-03	33	69	2	PF09379
Domain	FERM_N	FARP1 FARP2	6.60e-03	33	69	2	IPR018979
Pubmed	Gpr109a Limits Microbiota-Induced IL-23 Production To Constrain ILC3-Mediated Colonic Inflammation.	RAG1 HCAR3 HCAR2	3.26e-08	4	71	3	29514953
Pubmed	CD8+ T Cells Require ITK-Mediated TCR Signaling for Migration to the Intestine.	RAG1 RAG2 ITK	3.26e-08	4	71	3	32034085
Pubmed	The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response.	RAG1 IGHE	4.11e-06	2	71	2	24218137
Pubmed	The RAG recombinase dictates functional heterogeneity and cellular fitness in natural killer cells.	RAG1 RAG2	4.11e-06	2	71	2	25259923
Pubmed	Co-evolution of mutagenic genome editors and vertebrate adaptive immunity.	RAG1 RAG2	4.11e-06	2	71	2	32353821
Pubmed	The V(D)J recombination activating gene, RAG-1.	RAG1 RAG2	4.11e-06	2	71	2	2598259
Pubmed	Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization.	HCAR3 HCAR2	4.11e-06	2	71	2	28186140
Pubmed	Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet+ B cells.	RAG1 RAG2	4.11e-06	2	71	2	35902638
Pubmed	Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization.	RAG1 RAG2	4.11e-06	2	71	2	10458165
Pubmed	Loop extrusion mediates physiological Igh locus contraction for RAG scanning.	RAG1 RAG2	4.11e-06	2	71	2	33442057
Pubmed	RAG2 abolishes RAG1 aggregation to facilitate V(D)J recombination.	RAG1 RAG2	4.11e-06	2	71	2	34644584
Pubmed	The Immunometabolomic Interface Receptor Hydroxycarboxylic Acid Receptor 2 Mediates the Therapeutic Effects of Dimethyl Fumarate in Autoantibody-Induced Skin Inflammation.	HCAR3 HCAR2	4.11e-06	2	71	2	30154797
Pubmed	The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival.	HCAR3 HCAR2	4.11e-06	2	71	2	24371223
Pubmed	Mutations in Recombination Activating Gene 1 and 2 in patients with severe combined immunodeficiency disorders in Egypt.	RAG1 RAG2	4.11e-06	2	71	2	25869295
Pubmed	A Large Cohort of RAG1/2-Deficient SCID Patients-Clinical, Immunological, and Prognostic Analysis.	RAG1 RAG2	4.11e-06	2	71	2	31838659
Pubmed	Coordinate regulation of RAG1 and RAG2 by cell type-specific DNA elements 5' of RAG2.	RAG1 RAG2	4.11e-06	2	71	2	10446057
Pubmed	Activation of V(D)J recombination by RAG1 and RAG2.	RAG1 RAG2	4.11e-06	2	71	2	1492366
Pubmed	High dietary niacin may increase prostaglandin formation but does not increase tumor formation in ApcMin/+ mice.	HCAR3 HCAR2	4.11e-06	2	71	2	21774590
Pubmed	An immunodeficiency disease with RAG mutations and granulomas.	RAG1 RAG2	4.11e-06	2	71	2	18463379
Pubmed	The role of HCA2 (GPR109A) in regulating macrophage function.	HCAR3 HCAR2	4.11e-06	2	71	2	23882124
Pubmed	V(D)J recombination: molecular biology and regulation.	RAG1 RAG2	4.11e-06	2	71	2	1590991
Pubmed	Crosstalk between microbiome, regulatory T cells and HCA2 orchestrates the inflammatory response in a murine psoriasis model.	HCAR3 HCAR2	4.11e-06	2	71	2	36891315
Pubmed	Activation of the Tec Kinase ITK Controls Graded IRF4 Expression in Response to Variations in TCR Signal Strength.	RAG1 ITK	4.11e-06	2	71	2	32493815
Pubmed	Expression and V(D)J recombination activity of mutated RAG-1 proteins.	RAG1 RAG2	4.11e-06	2	71	2	8284210
Pubmed	Mechanistic basis for RAG discrimination between recombination sites and the off-target sites of human lymphomas.	RAG1 RAG2	4.11e-06	2	71	2	22064481
Pubmed	GPR109a Regulates Phenotypic and Functional Alterations in Macrophages and the Progression of Type 1 Diabetes.	HCAR3 HCAR2	4.11e-06	2	71	2	36208084
Pubmed	Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement.	RAG1 RAG2	4.11e-06	2	71	2	7584150
Pubmed	Expression of the recombinase-activating gene (RAG-1) in murine early embryogenesis.	RAG1 RAG2	4.11e-06	2	71	2	8934654
Pubmed	Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a.	HCAR3 HCAR2	4.11e-06	2	71	2	38007572
Pubmed	The role of the C-terminus of the human hydroxycarboxylic acid receptors 2 and 3 in G protein activation using Gα-engineered yeast cells.	HCAR3 HCAR2	4.11e-06	2	71	2	26656756
Pubmed	The Roles of the Interaction of BCL2-Antagonist/Killer 1, Apoptotic Peptidase Activating Factor 1 and Selenium in the Pathogenesis of Kashin-Beck Disease.	APAF1 BAK1	4.11e-06	2	71	2	26179084
Pubmed	B lineage-specific regulation of V(D)J recombinase activity is established in common lymphoid progenitors.	RAG1 RAG2	4.11e-06	2	71	2	14769852
Pubmed	Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.	HCAR3 HCAR2	4.11e-06	2	71	2	37597514
Pubmed	The Role of GPR109a Signaling in Niacin Induced Effects on Fed and Fasted Hepatic Metabolism.	HCAR3 HCAR2	4.11e-06	2	71	2	33924461
Pubmed	Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE.	HCAR3 HCAR2	4.11e-06	2	71	2	24691444
Pubmed	Novel mutatıons and diverse clinical phenotypes in recombinase-activating gene 1 deficiency.	RAG1 RAG2	4.11e-06	2	71	2	22424479
Pubmed	Ketone Body 3-Hydroxybutyrate Ameliorates Atherosclerosis via Receptor Gpr109a-Mediated Calcium Influx.	HCAR3 HCAR2	4.11e-06	2	71	2	33977048
Pubmed	Butyrate ameliorates caerulein-induced acute pancreatitis and associated intestinal injury by tissue-specific mechanisms.	HCAR3 HCAR2	4.11e-06	2	71	2	31347703
Pubmed	PUMA-G, an IFN-gamma-inducible gene in macrophages is a novel member of the seven transmembrane spanning receptor superfamily.	HCAR3 HCAR2	4.11e-06	2	71	2	11745392
Pubmed	Early death and severe lymphopenia caused by ubiquitous expression of the Rag1 and Rag2 genes in mice.	RAG1 RAG2	4.11e-06	2	71	2	11745397
Pubmed	Loss of GPR109A/HCAR2 induces aging-associated hepatic steatosis.	HCAR3 HCAR2	4.11e-06	2	71	2	30659164
Pubmed	Probing immune functions in RAG-deficient mice.	RAG1 RAG2	4.11e-06	2	71	2	8011215
Pubmed	Peripheral blood lymphocytes express recombination-activating genes 1 and 2 during Epstein-Barr virus-induced infectious mononucleosis.	RAG1 RAG2	4.11e-06	2	71	2	15295705
Pubmed	RAG-1-deficient mice have no mature B and T lymphocytes.	RAG1 RAG2	4.11e-06	2	71	2	1547488
Pubmed	Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets.	HCAR3 HCAR2	4.11e-06	2	71	2	25622782
Pubmed	Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination.	RAG1 RAG2	4.11e-06	2	71	2	21115692
Pubmed	Definition of a large region of RAG1 that is important for coimmunoprecipitation of RAG2.	RAG1 RAG2	4.11e-06	2	71	2	9036966
Pubmed	GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice.	HCAR3 HCAR2	4.11e-06	2	71	2	33420329
Pubmed	Endogenous TCR recombination in TCR Tg single RAG-deficient mice uncovered by robust in vivo T cell activation and selection.	RAG1 RAG2	4.11e-06	2	71	2	20454452
Pubmed	Expression and localization of GPR109A (PUMA-G/HM74A) mRNA and protein in mammalian retinal pigment epithelium.	HCAR3 HCAR2	4.11e-06	2	71	2	19223991
Pubmed	Understanding how the V(D)J recombinase catalyzes transesterification: distinctions between DNA cleavage and transposition.	RAG1 RAG2	4.11e-06	2	71	2	18375979
Pubmed	Molecular identification of nicotinic acid receptor.	HCAR3 HCAR2	4.11e-06	2	71	2	12646212
Pubmed	PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect.	HCAR3 HCAR2	4.11e-06	2	71	2	12563315
Pubmed	Autocrine motility factor promotes endometrial cancer progression by targeting GPER-1.	GPI GPER1	4.11e-06	2	71	2	30836961
Pubmed	Assembly Pathway and Characterization of the RAG1/2-DNA Paired and Signal-end Complexes.	RAG1 RAG2	4.11e-06	2	71	2	25903130
Pubmed	Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice.	HCAR3 HCAR2	4.11e-06	2	71	2	23967184
Pubmed	Development of CD4+CD8+ thymocytes in RAG-deficient mice through a T cell receptor beta chain-independent pathway.	RAG1 RAG2	4.11e-06	2	71	2	7869035
Pubmed	Mechanisms controlling expression of the RAG locus during lymphocyte development.	RAG1 RAG2	4.11e-06	2	71	2	19359154
Pubmed	Lack of expression of the recombination activating genes RAG-1 and RAG-2 in cutaneous T-cell lymphoma: pathogenic implications.	RAG1 RAG2	4.11e-06	2	71	2	9536544
Pubmed	The immunophenotypic and immunogenotypic B-cell differentiation arrest in bone marrow of RAG-deficient SCID patients corresponds to residual recombination activities of mutated RAG proteins.	RAG1 RAG2	4.11e-06	2	71	2	12200379
Pubmed	Involvement of the Niacin Receptor GPR109a in the LocalControl of Glucose Uptake in Small Intestine of Type 2Diabetic Mice.	HCAR3 HCAR2	4.11e-06	2	71	2	26371038
Pubmed	Heterogeneity in RAG1 and RAG2 deficiency: 35 cases from a single-centre.	RAG1 RAG2	4.11e-06	2	71	2	37724703
Pubmed	Transmembrane BAFF from rheumatoid synoviocytes requires interleukin-6 to induce the expression of recombination-activating gene in B lymphocytes.	RAG1 RAG2	4.11e-06	2	71	2	19404965
Pubmed	Expression of recombination activating genes 1 and 2 in peripheral B cells of patients with systemic lupus erythematosus.	RAG1 RAG2	4.11e-06	2	71	2	12115231
Pubmed	Alloreactive T cells deficient of the short-chain fatty acid receptor GPR109A induce less graft-versus-host disease.	HCAR3 HCAR2	4.11e-06	2	71	2	34653248
Pubmed	Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis.	RAG1 RAG2	4.11e-06	2	71	2	19396172
Pubmed	Reverse TCR repertoire evolution toward dominant low-affinity clones during chronic CMV infection.	RAG1 RAG2	4.11e-06	2	71	2	32205883
Pubmed	Phenolic acids suppress adipocyte lipolysis via activation of the nicotinic acid receptor GPR109A (HM74a/PUMA-G).	HCAR3 HCAR2	4.11e-06	2	71	2	19136666
Pubmed	Ordered assembly of the V(D)J synaptic complex ensures accurate recombination.	RAG1 RAG2	4.11e-06	2	71	2	12145216
Pubmed	G Protein-Coupled Receptor 109A Maintains the Intestinal Integrity and Protects Against ETEC Mucosal Infection by Promoting IgA Secretion.	HCAR3 HCAR2	4.11e-06	2	71	2	33488584
Pubmed	Structural basis for autoinhibition of the guanine nucleotide exchange factor FARP2.	FARP1 FARP2	4.11e-06	2	71	2	23375260
Pubmed	Clinical Manifestations, Mutational Analysis, and Immunological Phenotype in Patients with RAG1/2 Mutations: First Cases Series from Mexico and Description of Two Novel Mutations.	RAG1 RAG2	4.11e-06	2	71	2	33954879
Pubmed	Lactate-induced activation of HCA2 improves survival in mice with sepsis.	HCAR3 HCAR2	4.11e-06	2	71	2	30951370
Pubmed	Mapping and Quantitation of the Interaction between the Recombination Activating Gene Proteins RAG1 and RAG2.	RAG1 RAG2	4.11e-06	2	71	2	25745109
Pubmed	Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells.	RAG1 RAG2	4.11e-06	2	71	2	8953043
Pubmed	Structure-specific nuclease activity of RAGs is modulated by sequence, length and phase position of flanking double-stranded DNA.	RAG1 RAG2	4.11e-06	2	71	2	25327637
Pubmed	Niacin Ameliorates Hepatic Steatosis by Inhibiting De Novo Lipogenesis Via a GPR109A-Mediated PKC-ERK1/2-AMPK Signaling Pathway in C57BL/6 Mice Fed a High-Fat Diet.	HCAR3 HCAR2	4.11e-06	2	71	2	31858105
Pubmed	A RAG1 mutation found in Omenn syndrome causes coding flank hypersensitivity: a novel mechanism for antigen receptor repertoire restriction.	RAG1 RAG2	4.11e-06	2	71	2	18768869
Pubmed	Deficiency of metabolite sensing receptor HCA2 impairs the salutary effect of niacin in hemorrhagic shock.	HCAR3 HCAR2	4.11e-06	2	71	2	30625381
Pubmed	Exploring the role of the metabolite-sensing receptor GPR109a in diabetic nephropathy.	HCAR3 HCAR2	4.11e-06	2	71	2	32068460
Pubmed	Amino acid residues in RAG1 responsible for the interaction with RAG2 during the V(D)J recombination process.	RAG1 RAG2	4.11e-06	2	71	2	14670978
Pubmed	Nuclear positioning rather than contraction controls ordered rearrangements of immunoglobulin loci.	RAG1 RAG2	4.11e-06	2	71	2	26384565
Pubmed	Crystal structure of the V(D)J recombinase RAG1-RAG2.	RAG1 RAG2	4.11e-06	2	71	2	25707801
Pubmed	Single-molecule analysis of RAG-mediated V(D)J DNA cleavage.	RAG1 RAG2	4.11e-06	2	71	2	25831509
Pubmed	Hypomorphic RAG deficiency: impact of disease burden on survival and thymic recovery argues for early diagnosis and HSCT.	RAG1 RAG2	4.11e-06	2	71	2	36279417
Pubmed	RAG-heptamer interaction in the synaptic complex is a crucial biochemical checkpoint for the 12/23 recombination rule.	RAG1 RAG2	4.11e-06	2	71	2	18089566
Pubmed	An interdomain boundary in RAG1 facilitates cooperative binding to RAG2 in formation of the V(D)J recombinase complex.	RAG1 RAG2	4.11e-06	2	71	2	25676158
Pubmed	The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome.	HCAR3 HCAR2	4.11e-06	2	71	2	30657794
Pubmed	Ketones and pain: unexplored role of hydroxyl carboxylic acid receptor type 2 in the pathophysiology of neuropathic pain.	HCAR3 HCAR2	4.11e-06	2	71	2	30085883
Pubmed	Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet.	RAG1 ITK	4.11e-06	2	71	2	15345221
Pubmed	Differential reaction kinetics, cleavage complex formation, and nonamer binding domain dependence dictate the structure-specific and sequence-specific nuclease activity of RAGs.	RAG1 RAG2	4.11e-06	2	71	2	22119487
Pubmed	Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation.	HCAR3 HCAR2	4.11e-06	2	71	2	21655214
Pubmed	Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway.	HCAR3 HCAR2	4.11e-06	2	71	2	34092246
Pubmed	Yeast and human P4-ATPases transport glycosphingolipids using conserved structural motifs.	ATP10A ATP10D	4.11e-06	2	71	2	30530492
Pubmed	(D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G.	HCAR3 HCAR2	4.11e-06	2	71	2	15929991
Pubmed	The immune system prevents recurrence of transplanted but not autochthonous antigenic tumors after oncogene inactivation therapy.	RAG1 RAG2	4.11e-06	2	71	2	28833076
Pubmed	Analysis of mutations and recombination activity in RAG-deficient patients.	RAG1 RAG2	4.11e-06	2	71	2	21131235
Pubmed	Repair of chromosomal RAG-mediated DNA breaks by mutant RAG proteins lacking phosphatidylinositol 3-like kinase consensus phosphorylation sites.	RAG1 RAG2	4.11e-06	2	71	2	21742970
Pubmed	Cracking the DNA Code for V(D)J Recombination.	RAG1 RAG2	4.11e-06	2	71	2	29628308
Pubmed	Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models.	HCAR3 HCAR2	4.11e-06	2	71	2	36991440
Cytoband	Ensembl 112 genes in cytogenetic band chr11p12	RAG1 RAG2	3.96e-04	19	71	2	chr11p12
GeneFamily	ATPase phospholipid transporting	ATP8B3 ATP10A ATP10D	1.18e-05	15	55	3	1210
GeneFamily	Hydroxy-carboxylic acid receptors	HCAR3 HCAR2	2.72e-05	3	55	2	200
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	FARP1 ARHGEF17 FARP2	1.06e-03	66	55	3	722
GeneFamily	WD repeat domain containing	WDR93 WDHD1 APAF1 WDR17 EML3	1.18e-03	262	55	5	362
GeneFamily	Olfactory receptors, family 2	OR2T29 OR2T5 OR2J2	4.92e-03	113	55	3	149
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	FARP1 FARP2	1.01e-02	50	55	2	1293
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 BMP1 DISP2 RFX6 CHPF ARHGEF17	6.95e-07	195	71	6	bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCell	facs-Thymus-nan-3m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAG1 RAG2 KMT2C ATP10A ITK	1.46e-05	194	71	5	f1661f9f2439fca5c1012c693b0744c4e3b90a9b
ToppCell	facs-Thymus-nan\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAG1 RAG2 KMT2C ATP10A ITK	1.46e-05	194	71	5	cda1b197efb199330ea7ab25a7cee22cae22589d
ToppCell	facs-Thymus-nan-3m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAG1 RAG2 KMT2C ATP10A ITK	1.46e-05	194	71	5	66c056232ac216780acf4cc8ea325bd8ed1909c9
ToppCell	droplet-Heart-HEART-1m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP1 LDB3 CHPF ARHGEF17 PI15	1.54e-05	196	71	5	1eb14182ef26e6141f510d397b00bf8a12efda3e
Disease	severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive (is_implicated_in)	RAG1 RAG2	5.08e-06	2	67	2	DOID:0090013 (is_implicated_in)
Disease	Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive	RAG1 RAG2	5.08e-06	2	67	2	cv:C1832322
Disease	Combined Cellular And Humoral Immune Defects With Granulomas	RAG1 RAG2	5.08e-06	2	67	2	C2673536
Disease	combined cellular and humoral immune defects with granulomas (is_implicated_in)	RAG1 RAG2	5.08e-06	2	67	2	DOID:0112253 (is_implicated_in)
Disease	Combined immunodeficiency with skin granulomas	RAG1 RAG2	5.08e-06	2	67	2	cv:C2673536
Disease	COMBINED CELLULAR AND HUMORAL IMMUNE DEFECTS WITH GRANULOMAS	RAG1 RAG2	5.08e-06	2	67	2	233650
Disease	SEVERE COMBINED IMMUNODEFICIENCY, B CELL-NEGATIVE	RAG1 RAG2	5.08e-06	2	67	2	C1867362
Disease	Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, NK Cell-Positive	RAG1 RAG2	5.08e-06	2	67	2	C1832322
Disease	SEVERE COMBINED IMMUNODEFICIENCY, AUTOSOMAL RECESSIVE, T CELL-NEGATIVE, B CELL-NEGATIVE, NK CELL-POSITIVE	RAG1 RAG2	5.08e-06	2	67	2	601457
Disease	OMENN SYNDROME	RAG1 RAG2	1.52e-05	3	67	2	603554
Disease	Reticuloendotheliosis, familial, with eosinophilia	RAG1 RAG2	1.52e-05	3	67	2	C2931884
Disease	progressive familial intrahepatic cholestasis (implicated_via_orthology)	ATP10A ATP10D	1.52e-05	3	67	2	DOID:0070221 (implicated_via_orthology)
Disease	severe combined immunodeficiency (implicated_via_orthology)	RAG1 RAG2	1.52e-05	3	67	2	DOID:627 (implicated_via_orthology)
Disease	Omenn syndrome (is_implicated_in)	RAG1 RAG2	1.52e-05	3	67	2	DOID:0060010 (is_implicated_in)
Disease	Histiocytic medullary reticulosis	RAG1 RAG2	1.52e-05	3	67	2	cv:C2700553
Disease	tumor necrosis factor receptor superfamily member 19L measurement	PIKFYVE ARHGEF17	1.41e-04	8	67	2	EFO_0008309
Disease	severe combined immunodeficiency (is_implicated_in)	RAG1 RAG2	4.54e-04	14	67	2	DOID:627 (is_implicated_in)
Disease	Usual Interstitial Pneumonia	GPER1 RTEL1	8.47e-04	19	67	2	C4721509
Disease	Hamman-Rich Disease	GPER1 RTEL1	8.47e-04	19	67	2	C4721508
Disease	anorectal malformation	RTEL1 CSMD2	8.47e-04	19	67	2	MONDO_0019938
Disease	Omenn Syndrome	RAG1 RAG2	8.47e-04	19	67	2	C2700553
Disease	Severe Combined Immunodeficiency	RAG1 RAG2	9.40e-04	20	67	2	C0085110
Disease	Familial Idiopathic Pulmonary Fibrosis	GPER1 RTEL1	9.40e-04	20	67	2	C4721952
Disease	Idiopathic Pulmonary Fibrosis	GPER1 RTEL1	1.04e-03	21	67	2	C1800706
Disease	brain infarction, neuritic plaque measurement, Lewy body dementia, cerebral amyloid angiopathy, neurofibrillary tangles measurement	RAG1 ATP10A	1.14e-03	22	67	2	EFO_0004277, EFO_0006790, EFO_0006792, EFO_0006797, EFO_0006798
Disease	leiomyoma (is_marker_for)	BAK1 TSC2	1.85e-03	28	67	2	DOID:127 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
ADCRGHLSWVHGVMF	APAF1	876	O14727
LHSFSVEAPVSCMHW	ANAPC4	101	Q9UJX5
MAICTRHPQGYHLWS	CSMD2	2506	Q7Z408
MFHAHWFCAGTDTVL	DNMT1	791	P26358
FMLHHCIARWIAQRG	BAK1	161	Q16611
GFCMSITMWIHLNHG	BCDIN3D	161	Q7Z5W3
MWRPVQLCHFHSALL	ADCK5	1	Q3MIX3
SRMHHFVGCLEWNDK	ATP8B3	311	O60423
GYSAHMHCVWRISVT	BMP1	341	P13497
MGRHVATSCHVAWLL	CDH23	1	Q9H251
SGSLWNLHAIHSMCR	DISP2	296	A7MBM2
LHGHWCYSRLANMVL	ATP10A	1076	O60312
VHGHWCYTRLSNMIL	ATP10D	1101	Q9P241
TFRCVQMLEWFEHHG	CLK1	221	P49759
HPTEFCHNCWSIMHR	RAG1	171	P15918
GHWVHAQCMDLAERT	RAG2	451	P55895
HTEHGRCMAWTEQQL	RFX6	721	Q8HWS3
NVIMSYHHCFWLTVG	OR8G2P	146	Q6IF36
QFLEQVRHCMQTWHA	ARHGEF17	1126	Q96PE2
AHHRCVEWSLGVCQM	KMT2C	251	Q8NEZ4
VMHALRQTWHTTCFV	LDB3	621	O75112
SICHTFQWHEAMFLL	HCAR2	181	Q8TDS4
DSWRHRLMHCVGFES	LCORL	41	Q8N3X6
CVLHNISLEHGMDVW	HARBI1	296	Q96MB7
ITMSFPFCRSWEIHH	OR2T5	166	Q6IEZ7
LLSGAHWMDQHFRTT	GPI	296	P06744
LMHPRFCHLLAAASW	OR2J2	136	O76002
LAFDFHWCTNGHLMC	CYHR1	76	Q6ZMK1
IMGHISCAQLAAASW	OR10A4	136	Q9H209
ITMSFPFCRSWEIHH	OR2T29	166	Q8NH02
CVHVHLDLTWCGLMF	OTOP2	161	Q7RTS6
QAMVDGRWLDCVSHH	PIKFYVE	411	Q9Y2I7
HHLAAISLMSFSWCA	CERS3	211	Q8IU89
HRGNTMVHVCWHRNT	FARP1	906	Q9Y4F1
QGVWLHTAHVLCMEA	ARFGEF3	981	Q5TH69
HPLESDTFFRMHWNC	FSCN3	331	Q9NQT6
GAWAKQMFTCRVAHT	IGHE	76	P01854
WTALFHCTSAGHQHM	ANKS3	136	Q6ZW76
EHCENTHMTIWLGIV	GABBR2	646	O75899
GRNHMAVHSCVARAW	LINC02913	96	Q8NAJ2
IHEMCHAASWLIDGI	GCNA	591	Q96QF7
RCMGHSSFITHLDWS	EML3	721	Q32P44
WRNSHTHCLWQMALG	CFAP141	26	Q5VU69
GQHRANTTMHVCWYR	FARP2	901	O94887
GHRCWTHMLDNGSAV	SLC22A11	46	Q9NSA0
MQSNHSCHWAKGLRF	KRBA2	376	Q6ZNG9
RLASTHVYQIMNHCW	ITK	581	Q08881
WCFSPGHSMHELVRQ	RTEL1	456	Q9NZ71
GHRCWVHMLDNNTGS	SLC22A10	46	Q63ZE4
SICHTFRWHEAMFLL	HCAR3	181	P49019
KHHARLSCGLIWMAS	GPER1	171	Q99527
SHMTWAHARLCFLLG	SH3TC2	521	Q8TF17
SFLSDICMFRWHTHQ	WDR17	171	Q8IZU2
HHIGVCSLARSMAVW	MROH2B	1241	Q7Z745
NRCRMHAISGWQAFF	CHPF	626	Q8IZ52
KLCHAWGLHSNISGM	C17orf64	166	Q86WR6
IHWRAGQHSQAMRCL	TONSL	211	Q96HA7
HLTHRFMVWNSIGII	WDHD1	441	O75717
HIICMTDAHTLSGWA	PKHD1L1	2141	Q86WI1
SIHIGHKQFMCQWCG	ZBTB47	596	Q9UFB7
HTRMEHYRGTFSLWC	SOCS7	446	O14512
MWHTLSHLGISVFSC	ZBTB39	496	O15060
GWCSSLRRHEMTHTG	ZNF101	376	Q8IZC7
MACVLGIHWTRSHNF	WDR93	376	Q6P2C0
CGEMFNWSSHLTEHQ	ZNF74	561	Q16587
FWVTAFRHHPQLSAM	TSPYL6	251	Q8N831
RQVTLMCHQTWSHSY	TRBV10-2	36	A0A0K0K1G8
MVWATSNRIGCAIHT	PI15	176	O43692
AMVHWSGHNSSVILI	SORCS1	176	Q8WY21
LCHELHTLFQVMWSG	USP44	381	Q9H0E7
VCLAHHVIAMWFIRC	TSC2	886	P49815
DLGTSCLIRHMWRAH	ZBED4	321	O75132
FCRLLGVEHSQMEHW	MYO5B	361	Q9ULV0