Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sialic acid binding	SIGLEC16 SIGLEC11	3.75e-04	25	23	2	GO:0033691
GeneOntologyMolecularFunction	carbohydrate binding	SIGLEC16 GUSB BCAN SIGLEC11	4.00e-04	310	23	4	GO:0030246
GeneOntologyBiologicalProcess	glycoside catabolic process	GBA3 GUSB	4.26e-05	9	23	2	GO:0016139
GeneOntologyBiologicalProcess	negative regulation of inflammatory response to wounding	SIGLEC16 SIGLEC11	9.21e-05	13	23	2	GO:0106015
GeneOntologyBiologicalProcess	regulation of inflammatory response to wounding	SIGLEC16 SIGLEC11	1.41e-04	16	23	2	GO:0106014
GeneOntologyBiologicalProcess	negative regulation of immunoglobulin production	SIGLEC16 SIGLEC11	2.23e-04	20	23	2	GO:0002638
GeneOntologyBiologicalProcess	glycoside metabolic process	GBA3 GUSB	2.71e-04	22	23	2	GO:0016137
HumanPheno	Epiphyseal stippling	GUSB GGCX PDE4D	2.45e-05	40	8	3	HP:0010655
HumanPheno	Calcific stippling	GUSB GGCX PDE4D	2.64e-05	41	8	3	HP:0002832
HumanPheno	Open bite	ADAMTS2 PDE4D POLR1C	8.77e-05	61	8	3	HP:0010807
HumanPheno	Generalized osteosclerosis	GUSB GGCX PDE4D	2.12e-04	82	8	3	HP:0005711
HumanPheno	Osteosclerosis	GUSB GGCX PDE4D	2.12e-04	82	8	3	HP:0010738
HumanPheno	Abnormal epiphyseal ossification	GUSB GGCX PDE4D	2.62e-04	88	8	3	HP:0010656
Domain	-	GBA3 GUSB	7.70e-04	35	22	2	3.20.20.80
Domain	Glyco_hydro_catalytic_dom	GBA3 GUSB	9.08e-04	38	22	2	IPR013781
Domain	Glycoside_hydrolase_SF	GBA3 GUSB	1.76e-03	53	22	2	IPR017853
Domain	Ig/MHC_CS	BCAN SIGLEC11	2.10e-03	58	22	2	IPR003006
Domain	IG_MHC	BCAN SIGLEC11	2.25e-03	60	22	2	PS00290
Domain	MetalloPept_cat_dom	MMP15 ADAMTS2	4.06e-03	81	22	2	IPR024079
Domain	-	MMP15 ADAMTS2	4.06e-03	81	22	2	3.40.390.10
Domain	ZINC_PROTEASE	MMP15 ADAMTS2	5.88e-03	98	22	2	PS00142
Domain	Peptidase_S1_PA	COX15 PROZ	9.12e-03	123	22	2	IPR009003
Domain	EGF	BCAN PROZ	9.55e-03	126	22	2	PF00008
Domain	IG	PXDNL BCAN SIGLEC11	1.27e-02	421	22	3	SM00409
Domain	Ig_sub	PXDNL BCAN SIGLEC11	1.27e-02	421	22	3	IPR003599
Pathway	REACTOME_GAMMA_CARBOXYLATION_OF_PROTEIN_PRECURSORS	GGCX PROZ	6.84e-05	9	20	2	MM14613
Pathway	REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS	GGCX PROZ	1.04e-04	11	20	2	M12484
Pathway	REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS	GGCX PROZ	1.04e-04	11	20	2	MM14615
Pathway	WP_VITAMIN_K_METABOLISM_AND_ACTIVATION_OF_DEPENDENT_PROTEINS	GGCX PROZ	1.48e-04	13	20	2	M45518
Pubmed	A human-specific gene in microglia.	SIGLEC16 SIGLEC11	4.18e-07	2	23	2	16151003
Pubmed	SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans.	SIGLEC16 SIGLEC11	4.18e-07	2	23	2	18629938
Pubmed	Siglec-G is a B1 cell-inhibitory receptor that controls expansion and calcium signaling of the B1 cell population.	SIGLEC16 SIGLEC11	1.25e-06	3	23	2	17572677
Pubmed	Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22.	SIGLEC16 SIGLEC11	1.25e-06	3	23	2	23836061
Pubmed	The role of Siglec-G on B cells in autoimmune disease and leukemia.	SIGLEC16 SIGLEC11	1.25e-06	3	23	2	38042621
Pubmed	The ligand-binding domain of Siglec-G is crucial for its selective inhibitory function on B1 cells.	SIGLEC16 SIGLEC11	1.25e-06	3	23	2	24790146
Pubmed	SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders.	SIGLEC16 SIGLEC11	1.25e-06	3	23	2	24859880
Pubmed	Siglecg limits the size of B1a B cell lineage by down-regulating NFkappaB activation.	SIGLEC16 SIGLEC11	2.51e-06	4	23	2	17912374
Pubmed	Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells.	SIGLEC16 SIGLEC11	2.51e-06	4	23	2	25252961
Pubmed	Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo.	SIGLEC16 SIGLEC11	2.51e-06	4	23	2	20038598
Pubmed	CD22 x Siglec-G double-deficient mice have massively increased B1 cell numbers and develop systemic autoimmunity.	SIGLEC16 SIGLEC11	2.51e-06	4	23	2	20200274
Pubmed	Siglec-G regulates B1 cell survival and selection.	SIGLEC16 SIGLEC11	2.51e-06	4	23	2	20729333
Pubmed	Sialic Acid Ligand Binding of CD22 and Siglec-G Determines Distinct B Cell Functions but Is Dispensable for B Cell Tolerance Induction.	SIGLEC16 SIGLEC11	2.51e-06	4	23	2	30143587
Pubmed	Siglec-G deficiency leads to more severe collagen-induced arthritis and earlier onset of lupus-like symptoms in MRL/lpr mice.	SIGLEC16 SIGLEC11	2.51e-06	4	23	2	24600033
Pubmed	Siglec-G-CD24 axis controls the severity of graft-versus-host disease in mice.	SIGLEC16 SIGLEC11	2.51e-06	4	23	2	24695850
Pubmed	Siglec-G Deficiency Leads to Autoimmunity in Aging C57BL/6 Mice.	SIGLEC16 SIGLEC11	4.18e-06	5	23	2	25987743
Pubmed	CD24 and Siglec-10 selectively repress tissue damage-induced immune responses.	SIGLEC16 SIGLEC11	4.18e-06	5	23	2	19264983
Pubmed	B Lymphocyte-Derived CCL7 Augments Neutrophil and Monocyte Recruitment, Exacerbating Acute Kidney Injury.	SIGLEC16 SIGLEC11	4.18e-06	5	23	2	32737150
Pubmed	The lectin Siglec-G inhibits dendritic cell cross-presentation by impairing MHC class I-peptide complex formation.	SIGLEC16 SIGLEC11	4.18e-06	5	23	2	27548433
Pubmed	Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells.	SIGLEC16 SIGLEC11	4.18e-06	5	23	2	26947073
Pubmed	Epistatic effects of Siglec-G and DNase1 or DNase1l3 deficiencies in the development of systemic lupus erythematosus.	SIGLEC16 SIGLEC11	4.18e-06	5	23	2	36969253
Pubmed	A hypomorphic IgH-chain allele affects development of B-cell subsets and favours receptor editing.	SIGLEC16 SIGLEC11	4.18e-06	5	23	2	21623346
Pubmed	Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G).	SIGLEC16 SIGLEC11	6.26e-06	6	23	2	14559209
Pubmed	Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia.	SIGLEC16 SIGLEC11	6.26e-06	6	23	2	11986327
Pubmed	Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen.	SIGLEC16 SIGLEC11	8.77e-06	7	23	2	28100677
Pubmed	Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation.	SIGLEC16 SIGLEC11	1.50e-05	9	23	2	23374343
Pubmed	CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder.	SIGLEC16 SIGLEC11	3.25e-05	13	23	2	35921817
Pubmed	The steroid and xenobiotic receptor negatively regulates B-1 cell development in the fetal liver.	SIGLEC16 SIGLEC11	4.37e-05	15	23	2	22496360
Pubmed	ADAMTS2 promotes radial migration by activating TGF-β signaling in the developing neocortex.	MMP15 ADAMTS2	4.37e-05	15	23	2	38871984
Pubmed	Association of warfarin dose with genes involved in its action and metabolism.	GGCX PROZ	4.99e-05	16	23	2	17048007
Pubmed	Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.	SIGLEC16 SIGLEC11	1.14e-04	24	23	2	15331780
Pubmed	Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes.	ECT2 PROZ	3.72e-04	43	23	2	30733279
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	GPBP1 ECT2 AHSA1 POLR1C	4.23e-04	547	23	4	37267103
Cytoband	19q13.33	SIGLEC16 SIGLEC11	1.29e-03	106	23	2	19q13.33
GeneFamily	CD molecules\|C2-set domain containing\|Sialic acid binding Ig like lectins	SIGLEC16 SIGLEC11	3.10e-04	28	17	2	745
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	SIGLEC16 PXDNL SIGLEC11	4.30e-04	161	17	3	593
GeneFamily	Adenosine receptors\|V-set domain containing	SIGLEC16 BCAN SIGLEC11	4.46e-04	163	17	3	590
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	SIGLEC16 SIGLEC11	6.36e-04	40	17	2	592
CoexpressionAtlas	DevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#1_top-relative-expression-ranked_500	ECT2 COX15 PIWIL2	3.02e-05	59	22	3	gudmap_developingGonad_e12.5_epididymis_k1_500
CoexpressionAtlas	DevelopingKidney_e15.5_Peripheral blastema_emap-27731_k-means-cluster#2_top-relative-expression-ranked_1000	REPS2 ADAMTS2 ECT2 COX15	9.00e-05	234	22	4	gudmap_developingKidney_e15.5_Peripheral blastema_1000_k2
CoexpressionAtlas	DevelopingGonad_P2_testes_emap-30171_top-relative-expression-ranked_1000	GPBP1 ADAMTS2 COX15 GUSB BCAN PIWIL2	1.42e-04	819	22	6	gudmap_developingGonad_P2_testes_1000
Drug	bilirubin glucoside	GBA3 GUSB	9.76e-07	2	23	2	CID006443775
Drug	glufosfamide	GBA3 ADAMTS2 GUSB	2.04e-06	25	23	3	CID000123628
Drug	ethyl anthranilate	GBA3 GUSB	2.93e-06	3	23	2	CID000006877
Drug	uranium nitrate	GBA3 GUSB	2.93e-06	3	23	2	CID000027534
Drug	phloroglucinaldehyde	GBA3 GUSB	2.93e-06	3	23	2	CID000068099
Drug	AC1NDR9H	GBA3 GUSB	2.93e-06	3	23	2	CID000020688
Drug	virgaureasaponin	GBA3 GUSB	2.93e-06	3	23	2	CID006324777
Drug	4-nitroso-m-cresol	GBA3 GUSB	5.85e-06	4	23	2	CID000011981
Drug	5-hydroxy-2-nitrobenzaldehyde	GBA3 GUSB	5.85e-06	4	23	2	CID000039211
Drug	gentisein	GBA3 GUSB	5.85e-06	4	23	2	CID005281635
Drug	4'-O-(beta-D-glucopyranosyl)-D-pantothenic acid	GBA3 GUSB	5.85e-06	4	23	2	CID003082306
Drug	p-Nitrophenyl alpha-D-xyloside	GBA3 GUSB PDE4D	9.36e-06	41	23	3	CID000082482
Drug	velutin	GBA3 GUSB	9.74e-06	5	23	2	CID005464381
Drug	AC1L8VCN	GBA3 GUSB	9.74e-06	5	23	2	CID000408702
Drug	methylazoxymethyl-beta-D-glucosiduronic acid	GBA3 GUSB	9.74e-06	5	23	2	CID000149476
Drug	4'-O-(beta-D-glucopyranosyl)-D-hopantenic acid	GBA3 GUSB	1.46e-05	6	23	2	CID000129183
Drug	X1207	GBA3 GUSB	1.46e-05	6	23	2	CID000084718
Drug	7-OHIQ	GBA3 GUSB	1.46e-05	6	23	2	CID000115222
Drug	isoflavone	MMP15 GBA3 ADAMTS2 GUSB	1.65e-05	155	23	4	CID000072304
Drug	ND2001	GBA3 GUSB	2.04e-05	7	23	2	CID000160207
Drug	glycitin	GBA3 GUSB	2.04e-05	7	23	2	CID000187808
Drug	PNPG	GBA3 GUSB	2.72e-05	8	23	2	CID000082565
Drug	nitarsone	GBA3 GUSB	2.72e-05	8	23	2	CID000066826
Drug	longum	GBA3 GUSB PIWIL2	3.44e-05	63	23	3	CID000009047
Drug	2-pyridinemethanol	GBA3 PDE4D	3.50e-05	9	23	2	CID000011474
Drug	1f3e	ADAMTS2 PROZ	4.37e-05	10	23	2	CID000001616
Drug	O-desmethylangolensin	GBA3 GUSB	6.40e-05	12	23	2	CID000089472
Drug	AC1L3MAP	GBA3 GUSB	6.40e-05	12	23	2	CID000091549
Drug	Menadione	GGCX PROZ	7.56e-05	13	23	2	DB00170
Drug	1,3-indandione	PDE4D PROZ	7.56e-05	13	23	2	CID000011815
Drug	18b-glycyrrhetic acid	GBA3 GUSB PDE4D	7.85e-05	83	23	3	CID000003230
Drug	1,2-dimethylhydrazine	GBA3 GUSB PROZ	8.72e-05	86	23	3	CID000001322
Drug	prunin	GBA3 GUSB	8.82e-05	14	23	2	CID000092794
Drug	ambodryl	GUSB PROZ	1.02e-04	15	23	2	CID000002444
Drug	hypoxoside	GBA3 GUSB	1.02e-04	15	23	2	CID006438448
Drug	4-nitro-phen-yl	GBA3 GUSB PDE4D	1.10e-04	93	23	3	CID000119211
Drug	rooperol	GBA3 GUSB	1.16e-04	16	23	2	CID006438989
Drug	BM 17.0744	GBA3 GUSB	1.16e-04	16	23	2	CID009929731
Drug	rutin	GBA3 GUSB PDE4D	1.29e-04	98	23	3	CID005280805
Drug	dihydro-vitamin K1	GGCX PROZ	1.32e-04	17	23	2	CID005189703
Drug	indoxyl-beta-D-glucoside	GBA3 GUSB	1.32e-04	17	23	2	CID000092769
Drug	phenazine-1-carboxylic acid	GUSB PROZ	1.48e-04	18	23	2	CID000095069
Drug	reduced vitamin K	GGCX PROZ	1.48e-04	18	23	2	CID000124102
Drug	cyclophellitol	GBA3 GUSB	1.65e-04	19	23	2	CID000164227
Drug	mandelonitrile	GBA3 GUSB	1.83e-04	20	23	2	CID000010758
Drug	2,6-dichloroisonicotinic acid	GBA3 GUSB	1.83e-04	20	23	2	CID000094830
Drug	maltosaccharide	GBA3 GUSB	2.23e-04	22	23	2	CID005461034
Drug	ginsenoside	GBA3 GUSB	2.44e-04	23	23	2	CID000092797
Drug	AC1L1KJQ	GBA3 GUSB	2.66e-04	24	23	2	CID000005529
Drug	AC1N5XY5	ECT2 GUSB	2.66e-04	24	23	2	CID004251231
Drug	Fast Blue BB	GBA3 GUSB	2.66e-04	24	23	2	CID000067108
Drug	saligenin	GBA3 GUSB	2.89e-04	25	23	2	CID000005146
Drug	phenyl glucoside	GBA3 GUSB	3.13e-04	26	23	2	CID000065080
Drug	a-sophorose	GBA3 GUSB	3.37e-04	27	23	2	CID000088719
Drug	CAS 520-26-3	GBA3 GUSB	3.63e-04	28	23	2	CID000003594
Drug	AC1NRA8W	GBA3 GUSB	3.90e-04	29	23	2	CID005287760
Drug	Nsc1222	GBA3 GUSB	4.17e-04	30	23	2	CID000219660
Drug	AC1L3MCS	GGCX PROZ	4.17e-04	30	23	2	CID000091577
Drug	enterocin	GBA3 GUSB	4.46e-04	31	23	2	CID000115182
Drug	esculin	GBA3 GUSB	4.75e-04	32	23	2	CID005281417
Drug	daidzin	GBA3 GUSB	5.06e-04	33	23	2	CID000107971
Drug	geniposide	GBA3 GUSB	5.06e-04	33	23	2	CID000107848
Drug	cyclopentadienyl	ADAMTS2 PROZ	5.06e-04	33	23	2	CID000137443
Drug	DB07831	GBA3 GGCX	6.02e-04	36	23	2	CID010477723
Drug	glycitein	GBA3 GUSB	6.02e-04	36	23	2	CID005317750
Drug	4-methylumbelliferyl-beta-D-glucopyranoside	GBA3 GUSB	6.36e-04	37	23	2	CID000087330
Drug	naphthol-AS-BI	GBA3 GUSB	6.36e-04	37	23	2	CID000071060
Drug	acrylamide	GBA3 PROZ	6.36e-04	37	23	2	CID000006579
Drug	genistin	GBA3 GUSB	6.71e-04	38	23	2	CID005281377
Drug	nojirimycin	GBA3 GUSB	6.71e-04	38	23	2	CID000065242
Drug	deamino-NADP	GBA3 GUSB	7.07e-04	39	23	2	CID000004482
Drug	indigo dye	GBA3 GUSB	7.44e-04	40	23	2	CID005318432
Drug	Trimethylsilyl	GBA3 GUSB	7.44e-04	40	23	2	CID000123362
Drug	Vitamin K1-d7	GGCX PROZ	7.44e-04	40	23	2	CID000004812
Drug	prochlorperazine dimaleate salt; Up 200; 10uM; PC3; HT_HG-U133A	MMP15 PROZ MCTP1	8.16e-04	184	23	3	4439_UP
Drug	LY 294002; Up 200; 10uM; PC3; HT_HG-U133A	PDE4D PROZ MCTP1	8.42e-04	186	23	3	4460_UP
Drug	AC1L1XLP	GBA3 GUSB	8.60e-04	43	23	2	CID000011554
Drug	LY294002; Up 200; 10uM; PC3; HT_HG-U133A	REPS2 PDE4D MCTP1	8.82e-04	189	23	3	5942_UP
Drug	Trioxsalen [3902-71-4]; Up 200; 17.6uM; PC3; HT_HG-U133A	GBA3 ZNF573 PDE4D	9.80e-04	196	23	3	5736_UP
Drug	CP-944629 [668990-94-1]; Up 200; 10uM; PC3; HT_HG-U133A	ZNF573 PDE4D MCTP1	9.80e-04	196	23	3	7502_UP
Drug	DL-1,2-anhydro-myo-inositol	GBA3 GUSB	9.83e-04	46	23	2	CID000002859
Drug	naringine	GBA3 GUSB	9.83e-04	46	23	2	CID000004441
Drug	Azlocillin sodium salt [37091-65-9]; Up 200; 8.2uM; PC3; HT_HG-U133A	TSPAN14 BCAN PDE4D	1.01e-03	198	23	3	5788_UP
Drug	Griseofulvin [126-07-8]; Up 200; 11.2uM; MCF7; HT_HG-U133A	BCAN PDE4D MCTP1	1.01e-03	198	23	3	2293_UP
Disease	skin pigmentation	ADAMTS2 PROZ	1.32e-03	69	23	2	EFO_0003784
Disease	sunburn	TSPAN14 PDE4D	2.53e-03	96	23	2	EFO_0003958
Disease	amyloid-beta measurement	GPBP1 PDE4D MCTP1	2.56e-03	355	23	3	EFO_0005194
Disease	RS-10-hydroxywarfarin measurement	GBA3 PDE4D	2.64e-03	98	23	2	EFO_0803330

Protein segments in the cluster

Peptide	Gene	Start	Entry
EEERTRQGWQRYYFE	AHSA1	311	O95433
DFREEQCRQWDLYFE	ADAMTS2	621	O95450
AWERRNEQDFYAAVD	ECT2	246	Q9H8V3
EQDFINNRYREYQWI	BCAN	731	Q96GW7
QWREQFDFHLYEERG	MCTP1	516	Q6DN14
RFSREELEWQNRFSD	LRSAM1	241	Q6UWE0
ENFAWTENRYDVNRR	GPBP1	31	Q86WP2
FQEDRYWRFNEETQR	MMP15	481	P51511
YRQWTDRIMEEFFRQ	PDE4D	631	Q08499
TQFQRLRDGDRFWYE	PXDNL	1221	A1KZ92
DTQRWEYFRQTFQEL	GBA3	386	Q9H227
FSDNRRRGFEEQWYR	GUSB	51	P08236
EWEAEFQRYQQFPEF	COX15	116	Q7KZN9
RYNNRTYRIDDVDWN	PIWIL2	421	Q8TC59
RECVFREQFEENWYN	FGF16	131	O43320
VFENEVVTDEFWRRY	PROZ	71	P22891
YDDAWDQDRFEKNFR	POLR1C	36	O15160
YFDIWVSINDRFQQR	GGCX	466	P38435
DFSRQEWEYLDPNQR	ZNF573	36	Q86YE8
WRITEEQREYYVNQF	REPS2	276	Q8NFH8
QDWVRDRFREFFESN	TSPAN14	116	Q8NG11
AQREDEAWYFFRVER	SIGLEC11	121	Q96RL6
IRDAQREDEAWYFFR	SIGLEC16	106	A6NMB1