Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glycogen phosphorylase activity	PYGB PYGL PYGM	3.61e-08	3	67	3	GO:0008184
GeneOntologyMolecularFunction	1,4-alpha-oligoglucan phosphorylase activity	PYGB PYGL PYGM	3.59e-07	5	67	3	GO:0004645
GeneOntologyMolecularFunction	pyridoxal phosphate binding	PYGB PYGL PYGM TAT	3.73e-05	56	67	4	GO:0030170
GeneOntologyMolecularFunction	vitamin B6 binding	PYGB PYGL PYGM TAT	4.00e-05	57	67	4	GO:0070279
GeneOntologyMolecularFunction	translation termination factor activity	MTRFR MRPL58	2.30e-04	7	67	2	GO:0008079
GeneOntologyMolecularFunction	translation release factor activity	MTRFR MRPL58	2.30e-04	7	67	2	GO:0003747
Domain	PHOSPHORYLASE	PYGB PYGL PYGM	4.02e-08	3	65	3	PS00102
Domain	Phosphorylase	PYGB PYGL PYGM	4.02e-08	3	65	3	PF00343
Domain	Glycg_phsphrylas	PYGB PYGL PYGM	4.02e-08	3	65	3	IPR011833
Domain	Glyco_trans_35	PYGB PYGL PYGM	4.02e-08	3	65	3	IPR000811
Domain	TRPV5/TRPV6	TRPV6 TRPV5	1.19e-05	2	65	2	IPR008344
Domain	Pep_chain_release_fac_I_II	MTRFR MRPL58	7.12e-05	4	65	2	IPR000352
Domain	RF-1	MTRFR MRPL58	7.12e-05	4	65	2	PF00472
Domain	RF_PROK_I	MTRFR MRPL58	7.12e-05	4	65	2	PS00745
Domain	TRP_channel	TRPV6 TRPV5	6.43e-04	11	65	2	IPR004729
Pathway	KEGG_MEDICUS_REFERENCE_GLYCOGEN_DEGRADATION	PYGB PYGL PYGM	3.27e-06	9	49	3	M47621
Pathway	REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS	PYGB PYGL PYGM	1.40e-05	14	49	3	M19193
Pathway	REACTOME_GLYCOGEN_METABOLISM	PYGB PYGL PYGM	8.60e-05	25	49	3	M27857
Pathway	WP_GLYCOGEN_METABOLISM	PYGB PYGL PYGM	2.19e-04	34	49	3	MM15985
Pubmed	PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts.	IRF9 ERBB2 BCAT2 TERT	1.00e-06	37	71	4	15735755
Pubmed	Localization of the muscle, liver, and brain glycogen phosphorylase genes on linkage maps of mouse chromosomes 19, 12, and 2, respectively.	PYGB PYGL PYGM	3.64e-06	15	71	3	2575583
Pubmed	Alteration of calcium homeostasis in primary preeclamptic syncytiotrophoblasts: effect on calcium exchange in placenta.	TRPV6 TRPV5	4.11e-06	2	71	2	20178461
Pubmed	The TRPV5/6 calcium channels contain multiple calmodulin binding sites with differential binding properties.	TRPV6 TRPV5	4.11e-06	2	71	2	22354706
Pubmed	Diverse calcium channel types are present in the human placental syncytiotrophoblast basal membrane.	TRPV6 TRPV5	4.11e-06	2	71	2	16564089
Pubmed	Endogenous expression of TRPV5 and TRPV6 calcium channels in human leukemia K562 cells.	TRPV6 TRPV5	4.11e-06	2	71	2	19295174
Pubmed	Human TRPV5 and TRPV6: key players in cadmium and zinc toxicity.	TRPV6 TRPV5	4.11e-06	2	71	2	23968883
Pubmed	Expression of calcium channels along the differentiation of cultured trophoblast cells from human term placenta.	TRPV6 TRPV5	4.11e-06	2	71	2	12390878
Pubmed	TRPV5 and TRPV6 are expressed in placenta and bone tissues during pregnancy in mice.	TRPV6 TRPV5	4.11e-06	2	71	2	30916584
Pubmed	Possible role of telomerase and sFas in pathogenesis of various bladder lesions associated with schistosomiasis.	FAS TERT	4.11e-06	2	71	2	19272297
Pubmed	Interaction of the epithelial Ca2+ channels TRPV5 and TRPV6 with the intestine- and kidney-enriched PDZ protein NHERF4.	TRPV6 TRPV5	4.11e-06	2	71	2	16565876
Pubmed	Age-dependent alterations in Ca2+ homeostasis: role of TRPV5 and TRPV6.	TRPV6 TRPV5	4.11e-06	2	71	2	16705151
Pubmed	Expression of transient receptor potential vanilloid channels TRPV5 and TRPV6 in retinal pigment epithelium.	TRPV6 TRPV5	4.11e-06	2	71	2	20405023
Pubmed	A single amino acid mutation results in a rapid inactivation of epithelial calcium channels.	TRPV6 TRPV5	4.11e-06	2	71	2	11846401
Pubmed	Expression and prognostic roles of TRPV5 and TRPV6 in non-small cell lung cancer after curative resection.	TRPV6 TRPV5	4.11e-06	2	71	2	24761864
Pubmed	Fast and slow inactivation kinetics of the Ca2+ channels ECaC1 and ECaC2 (TRPV5 and TRPV6). Role of the intracellular loop located between transmembrane segments 2 and 3.	TRPV6 TRPV5	4.11e-06	2	71	2	12077127
Pubmed	[The functional characteristics oF TRPV5 and TRPV6 channels in normal and transformed human blood lymphocytes].	TRPV6 TRPV5	4.11e-06	2	71	2	24592736
Pubmed	Solution structure and siRNA-mediated knockdown analysis of the mitochondrial disease-related protein C12orf65.	MTRFR MRPL58	4.11e-06	2	71	2	22821833
Pubmed	Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6.	TRPV6 TRPV5	4.11e-06	2	71	2	12574114
Pubmed	Structural conservation of the genes encoding CaT1, CaT2, and related cation channels.	TRPV6 TRPV5	4.11e-06	2	71	2	11549322
Pubmed	[TRPV5 and TRPV6 calcium channels in human T cells].	TRPV6 TRPV5	4.11e-06	2	71	2	19140341
Pubmed	First evidence of TRPV5 and TRPV6 channels in human parathyroid glands: possible involvement in neoplastic transformation.	TRPV6 TRPV5	4.11e-06	2	71	2	25164318
Pubmed	Regulation of the mouse epithelial Ca2(+) channel TRPV6 by the Ca(2+)-sensor calmodulin.	TRPV6 TRPV5	4.11e-06	2	71	2	15123711
Pubmed	Isoform-selective regulation of glycogen phosphorylase by energy deprivation and phosphorylation in astrocytes.	PYGB PYGM	4.11e-06	2	71	2	25130497
Pubmed	Single-channel activities of the human epithelial Ca2+ transport proteins CaT1 and CaT2.	TRPV6 TRPV5	4.11e-06	2	71	2	11719848
Pubmed	Concerted action of associated proteins in the regulation of TRPV5 and TRPV6.	TRPV6 TRPV5	4.11e-06	2	71	2	17233615
Pubmed	Transcriptional activation of hTERT in breast carcinomas by the Her2-ER81-related pathway.	ERBB2 TERT	1.23e-05	3	71	2	19718948
Pubmed	Identification of imprinted loci by methylation-sensitive representational difference analysis: application to mouse distal chromosome 2.	GNAS CDH15	1.23e-05	3	71	2	10610704
Pubmed	Lack of pendrin HCO3- transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channels.	TRPV6 TRPV5	1.23e-05	3	71	2	17200157
Pubmed	Overexpression of Telomerase Protects Human and Murine Lung Epithelial Cells from Fas- and Bleomycin-Induced Apoptosis via FLIP Upregulation.	FAS TERT	1.23e-05	3	71	2	25951185
Pubmed	Age-dependent changes in the expression of klotho protein, TRPV5 and TRPV6 in mouse inner ear.	TRPV6 TRPV5	1.23e-05	3	71	2	19922080
Pubmed	Identification of BSPRY as a novel auxiliary protein inhibiting TRPV5 activity.	TRPV6 TRPV5	1.23e-05	3	71	2	16380433
Pubmed	A molecular determinant of phosphoinositide affinity in mammalian TRPV channels.	TRPV6 TRPV5	1.23e-05	3	71	2	27291418
Pubmed	A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance.	ERBB2 SORL1	1.23e-05	3	71	2	33420373
Pubmed	Resistance to Ara-C up-regulates the activation of NF-kappaB, telomerase activity and Fas expression in NALM-6 cells.	FAS TERT	1.23e-05	3	71	2	17978477
Pubmed	Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport.	TRPV6 TRPV5	1.23e-05	3	71	2	16763551
Pubmed	Direct interaction with Rab11a targets the epithelial Ca2+ channels TRPV5 and TRPV6 to the plasma membrane.	TRPV6 TRPV5	1.23e-05	3	71	2	16354700
Pubmed	Analysis of a lung defect in autophagy-deficient mouse strains.	PYGB PYGL PYGM	2.05e-05	26	71	3	24275123
Pubmed	Mutations in C12orf65 in patients with encephalomyopathy and a mitochondrial translation defect.	MTRFR MRPL58	2.46e-05	4	71	2	20598281
Pubmed	The involvement of HER2 and p53 status in the regulation of telomerase in irradiated breast cancer cells.	ERBB2 TERT	2.46e-05	4	71	2	19787269
Pubmed	hTERT regulation by NF-κB and c-myc in irradiated HER2-positive breast cancer cells.	ERBB2 TERT	2.46e-05	4	71	2	21627565
Pubmed	Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex.	TRPV6 TRPV5	2.46e-05	4	71	2	12660155
Pubmed	A novel role of ADGRF1 (GPR110) in promoting cellular quiescence and chemoresistance in human epidermal growth factor receptor 2-positive breast cancer.	ERBB2 GNAS	2.46e-05	4	71	2	34110646
Pubmed	Characterising the dynamics of placental glycogen stores in the mouse.	PYGB PYGL PYGM	2.87e-05	29	71	3	32798765
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	KIF21B SFXN3 PYGB PYGL PYGM BCAN GNAS IDH3G	3.91e-05	621	71	8	22794259
Pubmed	Role and regulation of TRP channels in neutrophil granulocytes.	TRPV6 TRPV5	4.09e-05	5	71	2	12765698
Pubmed	Calcium transport genes are differently regulated in maternal and fetal placenta in the knockout mice of calbindin-D(9k) and -D(28k).	TRPV6 TRPV5	4.09e-05	5	71	2	22407925
Pubmed	The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine.	ERBB2 FAS	4.09e-05	5	71	2	7507509
Pubmed	Noncanonical Effects of IRF9 in Intestinal Inflammation: More than Type I and Type III Interferons.	IRF9 IFNLR1	4.09e-05	5	71	2	25918247
Pubmed	Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue.	PTGES2 AFG3L2 PYGB BCAT2 PYGM IDH3G	6.05e-05	331	71	6	29199018
Pubmed	Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects.	TRPV6 TRPV5	1.14e-04	8	71	2	33859252
Pubmed	Soluble SORLA Enhances Neurite Outgrowth and Regeneration through Activation of the EGF Receptor/ERK Signaling Axis.	ERBB2 SORL1	1.47e-04	9	71	2	32601248
Pubmed	USP9X-mediated NRP1 deubiquitination promotes liver fibrosis by activating hepatic stellate cells.	PYGL FAS	1.83e-04	10	71	2	36653359
Pubmed	Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.	INHBE GHDC TMEM59 SFXN3 SLC35E1 TMED7	2.51e-04	430	71	6	16303743
Pubmed	A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool.	ERBB2 MAP2K2	2.68e-04	12	71	2	10704452
Pubmed	Ran binding protein 9 interacts with Raf kinase but does not contribute to downstream ERK1/2 activation in skeletal myoblasts.	TMEM70 MAP2K2	2.68e-04	12	71	2	16364241
Pubmed	Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryos.	TRPV6 TRPV5	3.16e-04	13	71	2	22266179
Pubmed	Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.	ERBB2 MAP2K2	4.24e-04	15	71	2	18760695
Pubmed	Deficiency of Lipoprotein Lipase in Neurons Decreases AMPA Receptor Phosphorylation and Leads to Neurobehavioral Abnormalities in Mice.	FAS SORL1	4.84e-04	16	71	2	26263173
Pubmed	A multilocus linkage map of mouse chromosome 8.	FAS TAT	4.84e-04	16	71	2	2037298
Pubmed	Tat protein induces self-perpetuating permissivity for productive HIV-1 infection.	FAS MAP2K2	4.84e-04	16	71	2	9223324
Pubmed	Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.	PTGES2 MTRFR TMEM70 AFG3L2 SFXN3 MRPL58 BCAT2 COX18 IDH3G	4.96e-04	1136	71	9	34800366
Pubmed	Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.	DNAAF5 AFG3L2 SFXN3 GNAS MAP2K2	5.28e-04	323	71	5	24797263
Pubmed	Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.	IRF9 ARHGEF40	5.48e-04	17	71	2	12693554
Pubmed	Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study.	TMEM70 COX18	5.48e-04	17	71	2	20200953
Pubmed	Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry.	PTGES2 MTRFR AFG3L2 BCAT2 IDH3G	6.93e-04	343	71	5	28130547
Pubmed	Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series.	PYGL PYGM IDH3G	9.27e-04	93	71	3	27215380
Pubmed	Mapping the expression of transient receptor potential channels across murine placental development.	TRPV6 TRPV5	1.10e-03	24	71	2	33884443
Pubmed	International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.	TRPV6 TRPV5	1.20e-03	25	71	2	16382100
Pubmed	A mitochondrial protein compendium elucidates complex I disease biology.	PTGES2 TMEM70 AFG3L2 SFXN3 MRPL58 BCAT2 COX18 IDH3G	1.31e-03	1047	71	8	18614015
Pubmed	SCAP knockout in SM22α-Cre mice induces defective angiogenesis in the placental labyrinth.	PIGF MAP2K2	1.40e-03	27	71	2	33227706
Pubmed	An introduction to TRP channels.	TRPV6 TRPV5	1.40e-03	27	71	2	16460286
Pubmed	The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice.	FAS CDH15	1.61e-03	29	71	2	28364022
Pubmed	Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.	PTGES2 AFG3L2 SFXN3 PYGB PYGL	1.73e-03	422	71	5	27342126
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ERBB2 ARHGEF40 SLC45A3 NINL PYGB HERC1 PRRT4 IFNLR1	1.83e-03	1105	71	8	35748872
Pubmed	Specific functions for ERK/MAPK signaling during PNS development.	ERBB2 MAP2K2	1.84e-03	31	71	2	21220101
Cytoband	11q13.2	TBC1D10C PELI3 TMEM151A	5.47e-05	47	71	3	11q13.2
Cytoband	1q32.1	KIF21B GPR25 SLC45A3	6.44e-04	108	71	3	1q32.1
Cytoband	5p15.33	PLEKHG4B TERT	1.14e-03	32	71	2	5p15.33
Cytoband	14q11.2	IRF9 ARHGEF40 KLHL33	2.79e-03	180	71	3	14q11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr7q34	KIAA1549 TRPV6 TRPV5	3.01e-03	185	71	3	chr7q34
Cytoband	Ensembl 112 genes in cytogenetic band chr11q13	TBC1D10C PELI3 PYGM TMEM151A	5.44e-03	454	71	4	chr11q13
Cytoband	6p21.1	DLK2 TREML2	6.89e-03	80	71	2	6p21.1
Cytoband	Ensembl 112 genes in cytogenetic band chr6p21	ETV7 DLK2 KCNK16 TREML2	7.76e-03	503	71	4	chr6p21
GeneFamily	Glycogen phosphorylases	PYGB PYGL PYGM	1.44e-08	3	45	3	437
GeneFamily	Transient receptor potential cation channels	TRPV6 TRPV5	2.20e-03	28	45	2	249
GeneFamily	Endogenous ligands\|Minor histocompatibility antigens	ERBB2 BCAT2	7.15e-03	51	45	2	870
GeneFamily	Adenosine receptors\|V-set domain containing	SIGLEC9 BCAN TREML2	7.74e-03	163	45	3	590
Coexpression	CAIRO_PML_TARGETS_BOUND_BY_MYC_DN	IRF9 ERBB2 BCAT2 TERT	3.47e-08	13	71	4	M1117
Coexpression	CAIRO_PML_TARGETS_BOUND_BY_MYC_DN	IRF9 ERBB2 BCAT2 TERT	3.47e-08	13	71	4	MM1098
Coexpression	ALCALA_APOPTOSIS	TBC1D10C NINL BCAT2 GNAS FAS	3.93e-06	87	71	5	M16169
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HMCN1 TRPV6 XKR6 ARL15 TRPV5	5.41e-06	158	71	5	7960337d87afecf2692ab65e5991f052ceddfacc
ToppCell	5'-Adult-SmallIntestine-Epithelial-neuro-epithelial-EECs\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NINL KIAA1549 XKR6 TMEM151A TERT	6.11e-06	162	71	5	478cf560ef33c5c324142c76417447d4a571a2c9
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HMCN1 XKR6 ARL15 TRPV5 SORL1	1.10e-05	183	71	5	2e831a4d99c6f983793df71c0994124c943c6da9
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NINL PYGB TRPV6 TMEM151A ARL15	1.32e-05	190	71	5	c408d4033a130c0168159a5b6f286fd2b2a9a39d
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NINL PYGB TRPV6 TMEM151A ARL15	1.32e-05	190	71	5	d4910c37045a8b8bb53b37625263bc0a47b6e3f8
Drug	3,5-dimethylphenyl isocyanate	PYGB PYGL PYGM	2.78e-08	3	70	3	CID000521488
Drug	5-ethyl-4-hydroxy-2-methyl-3(2H)-furanone	PYGB PYGL PYGM	2.78e-08	3	70	3	CID000093111
Drug	adenosine-5'-chloromethylphosphonate	PYGB PYGL PYGM	2.78e-08	3	70	3	CID000191554
Drug	hydan	PYGB PYGL PYGM	2.78e-08	3	70	3	CID000008360
Drug	EHMF	PYGB PYGL PYGM	2.78e-08	3	70	3	CID000033931
Drug	5'-deoxy-5'-fluoro-5'-(methylthio)adenosine	PYGB PYGL PYGM	2.78e-08	3	70	3	CID000147839
Drug	pyridoxal 5'-methylenephosphonate	PYGB PYGL PYGM	2.78e-08	3	70	3	CID003082249
Drug	Plp 5'-mpa	PYGB PYGL PYGM	2.78e-08	3	70	3	CID003082151
Drug	glucose-1,2-cyclic phosphate	PYGB PYGL PYGM	2.78e-08	3	70	3	CID000191723
Drug	3'-FFdUrd	PYGB PYGL PYGM	2.78e-08	3	70	3	CID000072260
Drug	2',3',4',5,5'-pentachloro-2-biphenylol	PYGB PYGL PYGM	2.78e-08	3	70	3	CID000119518
Drug	AC1L8XK3	PYGB PYGL PYGM	2.78e-08	3	70	3	CID000409735
Drug	N-acetyl-N'-beta-D-glucopyranosyl urea	PYGB PYGL PYGM	2.78e-08	3	70	3	CID000446801
Drug	NSC758405	PYGB PYGL PYGM	2.78e-08	3	70	3	CID000003201
Drug	3,5-dinitrophenyl phosphate	PYGB PYGL PYGM	2.78e-08	3	70	3	CID000151920
Drug	riboflavin tetraacetate	PYGB PYGL PYGM	2.78e-08	3	70	3	CID000094186
Drug	pyridoxal phosphoglucose	PYGB PYGL PYGM	2.78e-08	3	70	3	CID000196007
Drug	2,5-dimethyl-3-furanone	PYGB PYGL PYGM	2.78e-08	3	70	3	CID000085730
Drug	3,5-dinitrophenol	PYGB PYGL PYGM	2.78e-08	3	70	3	CID000011459
Drug	sotolon	PYGB BCAT2 PYGL PYGM	1.09e-07	15	70	4	CID000062835
Drug	galocitabine	PYGB PYGL PYGM	1.11e-07	4	70	3	CID000065950
Drug	2,5-anhydro-D-mannitol 1-phosphate	PYGB PYGL PYGM	1.11e-07	4	70	3	CID000189134
Drug	AC1LAMW2	PYGB PYGL PYGM	1.11e-07	4	70	3	CID000491364
Drug	FdUrd-C8	PYGB PYGL PYGM	1.11e-07	4	70	3	CID000094262
Drug	Mem-CC	PYGB PYGL PYGM	1.11e-07	4	70	3	CID003081269
Drug	5-deoxyribose-1-phosphate	PYGB PYGL PYGM	1.11e-07	4	70	3	CID000135786
Drug	ingliforib	PYGB PYGL PYGM	1.11e-07	4	70	3	CID006451325
Drug	uric acid riboside	PYGB PYGL PYGM	1.11e-07	4	70	3	CID000164933
Drug	pseudo-dl-glucose	PYGB PYGL PYGM	1.11e-07	4	70	3	CID000125259
Drug	BCIp4A	PYGB PYGL PYGM	1.11e-07	4	70	3	CID000192417
Drug	pyridoxal diphosphate	PYGB PYGL PYGM	1.11e-07	4	70	3	CID000125696
Drug	3'-chloromethotrexate	PYGB PYGL PYGM	1.11e-07	4	70	3	CID000097703
Drug	F-6b	PYGB PYGL PYGM FAS	1.45e-07	16	70	4	CID000004288
Drug	heptulose-2-P	PYGB PYGL PYGM	2.77e-07	5	70	3	CID000124823
Drug	m-anisidine	PYGB PYGL PYGM	2.77e-07	5	70	3	CID000010824
Drug	6-FPLP	PYGB PYGL PYGM	2.77e-07	5	70	3	CID000146246
Drug	gluconohydroximo-1,5-lactone	PYGB PYGL PYGM	2.77e-07	5	70	3	CID009576855
Drug	2-hydroxypropylphosphonate	PYGB PYGL PYGM	2.77e-07	5	70	3	CID000441028
Drug	DHPBU	PYGB PYGL PYGM	2.77e-07	5	70	3	CID000125914
Drug	6-FDPL	PYGB PYGL PYGM	2.77e-07	5	70	3	CID000129578
Drug	5'-isobutylthioinosine	PYGB PYGL PYGM	2.77e-07	5	70	3	CID003080910
Drug	3'-O-methylpyridoxal 5'-phosphate	PYGB PYGL PYGM	2.77e-07	5	70	3	CID003082179
Drug	GlcMan	PYGB PYGL PYGM	2.77e-07	5	70	3	CID000152120
Drug	U66985	PYGB PYGL PYGM	2.77e-07	5	70	3	CID000127224
Drug	indirubin-5-sulphonate	PYGB PYGL PYGM	2.77e-07	5	70	3	CID005288641
Drug	AC1O3M08	PYGB PYGL PYGM	2.77e-07	5	70	3	CID006331955
Drug	AC1LCUXJ	PYGB PYGL PYGM	2.77e-07	5	70	3	CID000656425
Drug	6-amino-5-bromouracil	PYGB PYGL PYGM	2.77e-07	5	70	3	CID000080578
Drug	etafenone	PYGB PYGL PYGM	2.77e-07	5	70	3	CID000003275
Drug	ddEtUrd	PYGB PYGL PYGM	2.77e-07	5	70	3	CID000451452
Drug	5-trifluoromethyl-2'-deoxycytidine	PYGB PYGL PYGM	2.77e-07	5	70	3	CID000125618
Drug	CV-araU	PYGB PYGL PYGM	5.53e-07	6	70	3	CID006441877
Drug	2-thiothymidine	PYGB PYGL PYGM	5.53e-07	6	70	3	CID003005944
Drug	Carbocyclic Bvdc	PYGB PYGL PYGM	5.53e-07	6	70	3	CID006438602
Drug	DNPP	PYGB PYGL PYGM	5.53e-07	6	70	3	CID000067056
Drug	5-chloro-indole-2-carboxylic acid	PYGB PYGL PYGM	5.53e-07	6	70	3	CID000082693
Drug	2,2-dimethyl-3-hydroxybutyric acid	PYGB PYGL PYGM	5.53e-07	6	70	3	CID000152984
Drug	EdUMP	PYGB PYGL PYGM	5.53e-07	6	70	3	CID003085112
Drug	5'-deoxy-5'-chloroformycin	PYGB PYGL PYGM	5.53e-07	6	70	3	CID000126430
Drug	NSC-97433	PYGB PYGL PYGM	5.53e-07	6	70	3	CID000001803
Drug	5-n-propylthioadenosine	PYGB PYGL PYGM	5.53e-07	6	70	3	CID000656428
Drug	AzddCyd	PYGB PYGL PYGM	5.53e-07	6	70	3	CID000451374
Drug	5-Ffdru	PYGB PYGL PYGM	5.53e-07	6	70	3	CID000065561
Drug	AR-L57	PYGB PYGL PYGM	5.53e-07	6	70	3	CID000156890
Drug	Carbocyclic Ivdu	PYGB PYGL PYGM	5.53e-07	6	70	3	CID006439191
Drug	Pyridoxal Phosphate	PYGB BCAT2 PYGL PYGM TAT	6.08e-07	53	70	5	DB00114
Drug	BrVarafUTP	PYGB PYGL PYGM TERT	8.31e-07	24	70	4	CID005273539
Drug	alpha-(fluoromethyl)dehydroornithine	PYGB PYGL PYGM	9.66e-07	7	70	3	CID006439607
Drug	6-fluoropyridoxal	PYGB PYGL PYGM	9.66e-07	7	70	3	CID003080803
Drug	2',3'-dideoxy-3'-fluorocytidine	PYGB PYGL PYGM	9.66e-07	7	70	3	CID000356019
Drug	heptenitol	PYGB PYGL PYGM	9.66e-07	7	70	3	CID000188267
Drug	AC1L3372	PYGB PYGL PYGM	9.66e-07	7	70	3	CID000108025
Drug	1 Gpt	PYGB PYGL PYGM	9.66e-07	7	70	3	CID000101247
Drug	formycins	PYGB PYGL PYGM	9.66e-07	7	70	3	CID000512867
Drug	Promonta	PYGB PYGL PYGM	9.66e-07	7	70	3	CID000108494
Drug	5'-methylthioinosine	PYGB PYGL PYGM	9.66e-07	7	70	3	CID000161214
Drug	hydantocidin	PYGB PYGL PYGM	9.66e-07	7	70	3	CID000125429
Drug	FUTP	PYGB PYGL PYGM TAT	1.36e-06	27	70	4	CID000122060
Drug	AC1NUVX5	PYGB PYGL PYGM	1.54e-06	8	70	3	CID005461894
Drug	6-methylpurine	PYGB PYGL PYGM	1.54e-06	8	70	3	CID005287547
Drug	amorphin	PYGB PYGL PYGM	1.54e-06	8	70	3	CID000122792
Drug	Etafenone [inn]	PYGB PYGL PYGM	1.54e-06	8	70	3	CID000066659
Drug	6-benzyl-2-thiouracil	PYGB PYGL PYGM	2.31e-06	9	70	3	CID000685814
Drug	5'-methylthiotubercidin	PYGB PYGL PYGM	2.31e-06	9	70	3	CID000188350
Drug	alpha-maltosyl fluoride	PYGB PYGL PYGM	2.31e-06	9	70	3	CID000194237
Drug	5-Iodoribose 1-phosphate	PYGB PYGL PYGM	2.31e-06	9	70	3	CID003035973
Drug	5'-iodo-5'-deoxyadenosine	PYGB PYGL PYGM	2.31e-06	9	70	3	CID000107502
Drug	8-azidoadenosine 5'-monophosphate	PYGB PYGL PYGM	3.29e-06	10	70	3	CID000124726
Drug	2,6-dihydroxypyridine	PYGB PYGL PYGM	3.29e-06	10	70	3	CID000069371
Drug	6-methyluridine	PYGB PYGL PYGM	3.29e-06	10	70	3	CID000092887
Drug	UDP-pyridoxal	PYGB PYGL PYGM	3.29e-06	10	70	3	CID000126789
Drug	alpha-ketoisocaproate	PYGB BCAT2 PYGL PYGM TAT	4.49e-06	79	70	5	CID000000070
Drug	glucosyl fluoride	PYGB PYGL PYGM	4.51e-06	11	70	3	CID000150967
Drug	Cid 11299980	PYGB PYGL PYGM	4.51e-06	11	70	3	CID009856533
Drug	9 Da	PYGB PYGL PYGM	4.51e-06	11	70	3	CID005287565
Drug	L-BVAU	PYGB PYGL PYGM TERT	5.59e-06	38	70	4	CID000667554
Drug	BCX-34	PYGB PYGL PYGM	6.00e-06	12	70	3	CID000060817
Drug	Ap4U	PYGB PYGL PYGM	6.00e-06	12	70	3	CID000165888
Drug	phenylurethane	PYGB PYGL PYGM	6.00e-06	12	70	3	CID000007591
Drug	acyclothymidine	PYGB PYGL PYGM	6.00e-06	12	70	3	CID000072358
Disease	Mitochondrial Encephalomyopathies	MTRFR TMEM70	1.45e-04	8	68	2	C0162666
Disease	aplastic anemia (is_marker_for)	FAS TERT	1.86e-04	9	68	2	DOID:12449 (is_marker_for)
Disease	Sclerocystic Ovaries	TRPV6 GNAS TMEM151A CDH15	3.48e-04	144	68	4	C1136382
Disease	Polycystic Ovary Syndrome	TRPV6 GNAS TMEM151A CDH15	3.48e-04	144	68	4	C0032460
Disease	transitional cell carcinoma (is_marker_for)	ERBB2 FAS TERT	4.21e-04	63	68	3	DOID:2671 (is_marker_for)
Disease	glycerate measurement	MCTP1 HMCN1	5.39e-04	15	68	2	EFO_0021029
Disease	Malignant Glioma	ERBB2 TERT DMXL1	5.74e-04	70	68	3	C0555198
Disease	mixed gliomas	ERBB2 TERT DMXL1	5.74e-04	70	68	3	C0259783
Disease	urinary bladder cancer (is_implicated_in)	ERBB2 FAS TERT	7.30e-04	76	68	3	DOID:11054 (is_implicated_in)
Disease	telomere length	MCTP1 GHDC NINL PYGB TERT	7.85e-04	313	68	5	EFO_0004505
Disease	macula measurement	TSPAN10 LRP11 NINL SORL1	9.64e-04	189	68	4	EFO_0008375
Disease	myelodysplastic syndrome (is_marker_for)	FAS TERT	9.68e-04	20	68	2	DOID:0050908 (is_marker_for)
Disease	Glioma	ERBB2 TERT DMXL1	1.08e-03	87	68	3	C0017638
Disease	Intrahepatic Cholangiocarcinoma	ERBB2 GNAS	1.40e-03	24	68	2	C0345905
Disease	Extrahepatic Cholangiocarcinoma	ERBB2 GNAS	1.40e-03	24	68	2	C3805278
Disease	Cholangiocarcinoma	ERBB2 GNAS	1.64e-03	26	68	2	C0206698
Disease	Glycogen Storage Disease	PYGL PYGM	1.77e-03	27	68	2	C0017919
Disease	Pigmented Basal Cell Carcinoma	ERBB2 TERT	1.90e-03	28	68	2	C1368275
Disease	hepatocellular carcinoma (biomarker_via_orthology)	FAS MAP2K2 TERT	2.01e-03	108	68	3	DOID:684 (biomarker_via_orthology)
Disease	anxiety measurement	TRPV6 XKR6 TRPV5	2.01e-03	108	68	3	EFO_0009863
Disease	Carcinoma, Basal Cell	ERBB2 TERT	2.04e-03	29	68	2	C4721806
Disease	Cholestasis	TMED7 GNAS SORL1	2.12e-03	110	68	3	C0008370

Protein segments in the cluster

Peptide	Gene	Start	Entry
LCRWGLLLALLPPGA	ERBB2	6	P04626
CISWQRPTGIPLGNL	nan	166	Q9N2K0
MLCRLGGRWLRPLPA	COX18	1	Q8N8Q8
SGIQRLPWAELICPR	ARHGEF40	171	Q8TER5
LEPLARGKRWILQPC	ARL15	161	Q9NXU5
RGGCWPRGLQQLLVP	AFG3L2	11	Q9Y4W6
PLPCPLLLALRWGLT	GPR25	276	O00155
RWQGCTRPALLAPSL	ADORA2A-AS1	136	P86434
IAWVRICRPGLVIGP	CDC14C	311	A4D256
PAQWPGITCLIRLLN	DMXL1	2291	Q9Y485
GWLCKTLRLNQPGTP	MAP2K2	381	P36507
CARRRRPGLLLPGLW	KIAA1549	36	Q9HCM3
LPGLWLLLLARPASC	KIAA1549	46	Q9HCM3
GRLLGRWKALLIPPS	BCAN	891	Q96GW7
LGRWLCLGTLPRPRA	KLHL33	491	A6NCF5
LLLCLWLPSGRAALP	LRP11	26	Q86VZ4
LFWRTCGRPALPVLG	MCTP1	421	Q6DN14
PILSCGGLAKRWLVP	TAT	271	P17735
RWGPLLLCLLQAAPG	IFNLR1	6	Q8IU57
LPLGPLLLHRCCQLW	KCNK16	251	Q96T55
SRRLWLGPQCSKLPL	ATXN8OS	56	P0DMR3
WGIVQGQLRPLLAPR	HERC1	4436	Q15751
LPLWLPRGCSGILSV	CCDC9B	26	Q6ZUT6
LPTLPGTLCLRIFRW	INHBE	131	P58166
LWNYVPGLTPCLPRR	KIF21B	1611	O75037
QGPRGLALRLWPKLQ	GHDC	246	Q8N2G8
PALRSLRLDGNPWLC	LRRC38	176	Q5VT99
VRRLGCLLERLPWSP	OC90	356	Q02509
CTLLAGNPIPERRWI	HMCN1	911	Q96RW7
QGGPRPRQLLLWLLI	PCDHA13	6	Q9Y5I0
LLAWRPGCLRALGGP	ACP4	411	Q9BZG2
VLGPALLCRPWEVLG	IDH3G	16	P51553
CKLPGRLRIQPALWS	ETV7	41	Q9Y603
GVTDLRLWLCQPAPR	IGFL4	21	Q6B9Z1
LSRAGVWLLPPPARC	MRPL58	11	Q14197
CPPIGRRAATALLWL	GNAS	21	O95467
RGLFVQRLCPIPISW	IRF9	286	Q00978
GPWARLLLPRLLRCL	DNAAF5	71	Q86Y56
LLTLRAWRRGVCPPG	DLK2	326	Q6UY11
ARKLLSVPWLLCGPR	BCAT2	11	O15382
LCLSLGVPGWRRPTT	CDH15	16	P55291
RPNLSLPLVRCGWAC	FAM87A	91	P0C7U9
SRPWVFGPLLCRLSL	MLNR	101	O43193
LLPPGALCEVWTQRL	SORL1	21	Q92673
LLLLLLWPQGCVSGP	TREML2	6	Q5T2D2
LKRRPWLGAPLQVGL	SFXN3	256	Q9BWM7
PCLCLLGPNLKAWLR	PIGF	126	Q07326
LCRLVGPYVPLWLGQ	PELI3	386	Q8N2H9
GQPRLCRQPLTRALW	PRR14	11	Q9BWN1
PPARLSLSWRGLTLC	SIGLEC9	281	Q9Y336
CALAWRLGGRPQPLL	PTGES2	16	Q9H7Z7
WCRLATVPRLVLGPE	TMEM151A	61	Q8N4L1
ILALCAGLPPLLRAW	SLC35E1	66	Q96K37
LLPLRPGCGERPLAW	NINL	846	Q9Y2I6
FLIPRAGWLAGLLCP	SLC45A3	101	Q96JT2
GSLWVRTQLGLPPLL	TMEM59	6	Q9BXS4
PTPGAQRLCRLSVWI	XKR6	226	Q5GH73
TPLTRICPAPWGLRL	MTRFR	11	Q9H3J6
GITPRRWLVLCNPGL	PYGM	486	P11217
RSNLGWLCLLLLPIP	FAS	171	P25445
RPGLCALWDPLSLLR	PLEKHG4B	671	Q96PX9
KGIPSALRARCWPLL	TBC1D10C	91	Q8IV04
RWGCRLLALLLLVPG	TMED7	16	Q9Y3B3
GITPRRWLLLCNPGL	PYGB	486	P11216
RKLPRCLWPRSGICG	TRPV6	646	Q9H1D0
ALLALALLPWRCPPG	PRRT4	381	C9JH25
LEGCGPPLRRWLRAN	TSPAN10	276	Q9H1Z9
LGSPWAVELPLCGRR	TMEM70	6	Q9BUB7
GITPRRWLLLCNPGL	PYGL	486	P06737
LLVPGLPCLVRGGWP	WWC2-AS2	46	Q96NR7
RACLRRLVPPGLWGS	TERT	466	O14746
GGLLCALLTLRWPRP	TMEM198	156	Q66K66
RKLPRCLWPRSGICG	TRPV5	606	Q9NQA5