Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR1 RYR2	5.85e-05	4	63	2	GO:0005219
GeneOntologyMolecularFunction	cullin family protein binding	DCUN1D1 DCUN1D2 DCUN1D3	7.39e-05	26	63	3	GO:0097602
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	GRIK1 RYR1 RYR2	1.26e-04	31	63	3	GO:0099604
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR1 RYR2	1.46e-04	6	63	2	GO:0048763
GeneOntologyMolecularFunction	ubiquitin conjugating enzyme binding	DCUN1D1 DCUN1D2 DCUN1D3	1.98e-04	36	63	3	GO:0031624
GeneOntologyMolecularFunction	ubiquitin-like protein conjugating enzyme binding	DCUN1D1 DCUN1D2 DCUN1D3	3.15e-04	42	63	3	GO:0044390
GeneOntologyMolecularFunction	ubiquitin-like protein binding	OTUB2 DCUN1D1 DCUN1D2 DCUN1D3	7.16e-04	128	63	4	GO:0032182
GeneOntologyMolecularFunction	calcium channel activity	CACNG6 GRIK1 RYR1 RYR2	7.37e-04	129	63	4	GO:0005262
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	NPFFR2 NPY1R GPR32 CRHR2	8.27e-04	133	63	4	GO:0008528
GeneOntologyMolecularFunction	peptide receptor activity	NPFFR2 NPY1R GPR32 CRHR2	1.00e-03	140	63	4	GO:0001653
GeneOntologyMolecularFunction	organic acid binding	UBR1 FCN2 GRIK1 GOT2 RYR2	1.23e-03	254	63	5	GO:0043177
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNG6 GRIK1 RYR1 RYR2	1.32e-03	151	63	4	GO:0015085
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	RYR1 RYR2	1.45e-03	18	63	2	GO:0015278
GeneOntologyMolecularFunction	amino acid binding	UBR1 GRIK1 GOT2	1.59e-03	73	63	3	GO:0016597
GeneOntologyBiologicalProcess	positive regulation of protein neddylation	DCUN1D1 DCUN1D2 DCUN1D3	2.84e-07	5	64	3	GO:2000436
GeneOntologyBiologicalProcess	regulation of protein neddylation	DCUN1D1 DCUN1D2 DCUN1D3	3.13e-05	20	64	3	GO:2000434
Domain	DCN-prot	DCUN1D1 DCUN1D2 DCUN1D3	3.64e-07	5	63	3	IPR014764
Domain	PONY_dom	DCUN1D1 DCUN1D2 DCUN1D3	3.64e-07	5	63	3	IPR005176
Domain	DCUN1	DCUN1D1 DCUN1D2 DCUN1D3	3.64e-07	5	63	3	PS51229
Domain	Cullin_binding	DCUN1D1 DCUN1D2 DCUN1D3	3.64e-07	5	63	3	PF03556
Domain	Ryanrecept_TM4-6	RYR1 RYR2	3.35e-05	3	63	2	IPR009460
Domain	RyR	RYR1 RYR2	3.35e-05	3	63	2	PF02026
Domain	Ryanodine_rcpt	RYR1 RYR2	3.35e-05	3	63	2	IPR003032
Domain	RR_TM4-6	RYR1 RYR2	3.35e-05	3	63	2	PF06459
Domain	Ryan_recept	RYR1 RYR2	3.35e-05	3	63	2	IPR013333
Domain	EF_hand_dom	GUCA1C SPATA21 NECAB3 PPP2R3C RYR1 RYR2	1.30e-04	232	63	6	IPR002048
Domain	RIH_assoc	RYR1 RYR2	1.67e-04	6	63	2	PF08454
Domain	RIH_assoc-dom	RYR1 RYR2	1.67e-04	6	63	2	IPR013662
Domain	RIH_dom	RYR1 RYR2	1.67e-04	6	63	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 RYR2	1.67e-04	6	63	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 RYR2	1.67e-04	6	63	2	IPR015925
Domain	-	RYR1 RYR2	1.67e-04	6	63	2	1.25.10.30
Domain	RYDR_ITPR	RYR1 RYR2	1.67e-04	6	63	2	PF01365
Domain	Ins145_P3_rec	RYR1 RYR2	1.67e-04	6	63	2	PF08709
Domain	-	GUCA1C SPATA21 NECAB3 PPP2R3C RYR1 RYR2	2.45e-04	261	63	6	1.10.238.10
Domain	EF-hand-dom_pair	GUCA1C SPATA21 NECAB3 PPP2R3C RYR1 RYR2	4.07e-04	287	63	6	IPR011992
Domain	MIR	RYR1 RYR2	4.95e-04	10	63	2	PS50919
Domain	MIR	RYR1 RYR2	4.95e-04	10	63	2	PF02815
Domain	MIR	RYR1 RYR2	4.95e-04	10	63	2	SM00472
Domain	MIR_motif	RYR1 RYR2	4.95e-04	10	63	2	IPR016093
Domain	EF_HAND_2	GUCA1C SPATA21 NECAB3 PPP2R3C RYR2	1.09e-03	231	63	5	PS50222
Domain	PI3/4_kinase_CS	PI4KA PRKDC	1.14e-03	15	63	2	IPR018936
Domain	-	PI4KA PRKDC	1.30e-03	16	63	2	1.10.1070.11
Domain	PI3Kc	PI4KA PRKDC	1.30e-03	16	63	2	SM00146
Domain	UBA-like	DCUN1D1 LATS2 DCUN1D2	1.32e-03	64	63	3	IPR009060
Domain	PI3/4_kinase_cat_dom	PI4KA PRKDC	1.65e-03	18	63	2	IPR000403
Domain	PI3_PI4_kinase	PI4KA PRKDC	1.65e-03	18	63	2	PF00454
Domain	PI3_4_KINASE_3	PI4KA PRKDC	1.65e-03	18	63	2	PS50290
Domain	PI3_4_KINASE_1	PI4KA PRKDC	1.65e-03	18	63	2	PS00915
Domain	PI3_4_KINASE_2	PI4KA PRKDC	1.65e-03	18	63	2	PS00916
Domain	EFh	GUCA1C SPATA21 NECAB3 RYR2	1.99e-03	158	63	4	SM00054
Domain	EF_Hand_1_Ca_BS	GUCA1C SPATA21 NECAB3 PPP2R3C	2.89e-03	175	63	4	IPR018247
Domain	EF-hand_5	GUCA1C NECAB3	3.20e-03	25	63	2	PF13202
Domain	EF_HAND_1	GUCA1C SPATA21 NECAB3 PPP2R3C	4.98e-03	204	63	4	PS00018
Domain	EF-hand_8	RYR1 RYR2	5.86e-03	34	63	2	PF13833
Pubmed	The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae.	DCUN1D1 DCUN1D2 DCUN1D3	2.27e-07	7	66	3	15988528
Pubmed	The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes.	DCUN1D1 DCUN1D2 DCUN1D3	1.42e-06	12	66	3	19617556
Pubmed	Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes.	DCUN1D1 DCUN1D2 DCUN1D3	1.84e-06	13	66	3	23201271
Pubmed	Curcumin Delays Retinal Degeneration by Regulating Microglia Activation in the Retina of rd1 Mice.	PDE6B HPS4	3.55e-06	2	66	2	29145208
Pubmed	An intrinsic neural oscillator in the degenerating mouse retina.	PDE6B HPS4	3.55e-06	2	66	2	21451038
Pubmed	Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.	RYR1 RYR2	3.55e-06	2	66	2	17259277
Pubmed	Ryanodine receptor oligomeric interaction: identification of a putative binding region.	RYR1 RYR2	3.55e-06	2	66	2	14722100
Pubmed	Structural and functional interactions within ryanodine receptor.	RYR1 RYR2	3.55e-06	2	66	2	26009179
Pubmed	Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies-Present State, Challenges, and Perspectives.	RYR1 RYR2	3.55e-06	2	66	2	32899693
Pubmed	Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.	RYR1 RYR2	3.55e-06	2	66	2	30542613
Pubmed	An established light ear mutant (C57BL/6J-Pdeb(rd1) le) mouse cell line exhibits a block to secretion of lysosomal enzymes.	PDE6B HPS4	3.55e-06	2	66	2	10739679
Pubmed	Ryanodine receptors are expressed and functionally active in mouse spermatogenic cells and their inhibition interferes with spermatogonial differentiation.	RYR1 RYR2	3.55e-06	2	66	2	15280431
Pubmed	Expression of the ryanodine receptor isoforms in immune cells.	RYR1 RYR2	3.55e-06	2	66	2	11673493
Pubmed	B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators.	RYR1 RYR2	3.55e-06	2	66	2	11673462
Pubmed	Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.	RYR1 RYR2	3.55e-06	2	66	2	25370123
Pubmed	Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.	RYR1 RYR2	3.55e-06	2	66	2	15033925
Pubmed	Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels.	RYR1 RYR2	3.55e-06	2	66	2	18618700
Pubmed	Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.	DCUN1D1 DCUN1D2 DCUN1D3	5.22e-06	18	66	3	26906416
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PCNX2 UNC119 MAN2A2 LATS2 MYO9B SLC25A39 PI4KA PRKDC PLEC PPP2R3C RYR1	6.87e-06	1105	66	11	35748872
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR1 RYR2	1.06e-05	3	66	2	18403125
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR1 RYR2	1.06e-05	3	66	2	18434746
Pubmed	Separation of function for classical and ganglion cell photoreceptors with respect to circadian rhythm entrainment and induction of photosomnolence.	PDE6B HPS4	1.06e-05	3	66	2	21985934
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR1 RYR2	1.06e-05	3	66	2	9204703
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR1 RYR2	1.06e-05	3	66	2	7876312
Pubmed	Retinal degeneration increases susceptibility to myopia in mice.	PDE6B HPS4	1.06e-05	3	66	2	24146540
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR1 RYR2	1.06e-05	3	66	2	21881589
Pubmed	Dendritic differentiation of cerebellar Purkinje cells is promoted by ryanodine receptors expressed by Purkinje and granule cells.	RYR1 RYR2	1.06e-05	3	66	2	24123915
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR1 RYR2	1.06e-05	3	66	2	12213830
Pubmed	Dopamine D1 receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence.	RYR1 RYR2	1.06e-05	3	66	2	23278119
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR1 RYR2	1.06e-05	3	66	2	9242641
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR1 RYR2	1.06e-05	3	66	2	22948152
Pubmed	Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.	RYR1 RYR2	1.06e-05	3	66	2	23454728
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR1 RYR2	1.06e-05	3	66	2	10788707
Pubmed	Changes in expression of glutamate receptor subunits following photoreceptor degeneration in the rd mouse retina.	PDE6B GRIK1	1.06e-05	3	66	2	7538211
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR1 RYR2	1.06e-05	3	66	2	25239916
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR1 RYR2	1.06e-05	3	66	2	7621815
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR1 RYR2	1.06e-05	3	66	2	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR1 RYR2	1.06e-05	3	66	2	11159936
Pubmed	Intracellular calcium release channel expression during embryogenesis.	RYR1 RYR2	1.06e-05	3	66	2	9986730
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR1 RYR2	1.06e-05	3	66	2	10473538
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR1 RYR2	1.06e-05	3	66	2	7959768
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR1 RYR2	1.06e-05	3	66	2	4600883
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR1 RYR2	1.06e-05	3	66	2	7635066
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	RYR1 RYR2	2.12e-05	4	66	2	18206662
Pubmed	Increase of ryanodine receptors by dopamine D1 receptors is negatively regulated by γ-aminobutyric acid type B receptors in primary cultures of mouse cerebral cortical neurons.	RYR1 RYR2	2.12e-05	4	66	2	22504960
Pubmed	C57BL-6J mice with inherited retinal degeneration.	PDE6B HPS4	2.12e-05	4	66	2	4595403
Pubmed	Calmodulin modulates the termination threshold for cardiac ryanodine receptor-mediated Ca2+ release.	RYR1 RYR2	2.12e-05	4	66	2	23992453
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR1 RYR2	2.12e-05	4	66	2	23413940
Pubmed	Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.	RYR1 RYR2	2.12e-05	4	66	2	9384575
Pubmed	Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models.	PDE6B HPS4	2.12e-05	4	66	2	25477496
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR1 RYR2	2.12e-05	4	66	2	9607712
Pubmed	S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex.	RYR1 RYR2	2.12e-05	4	66	2	27226555
Pubmed	Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.	RYR1 RYR2	2.12e-05	4	66	2	19120137
Pubmed	Itaconate is an effector of a Rab GTPase cell-autonomous host defense pathway against Salmonella.	PDE6B HPS4	2.12e-05	4	66	2	32703879
Pubmed	FKBP binding characteristics of cardiac microsomes from diverse vertebrates.	RYR1 RYR2	2.12e-05	4	66	2	11237759
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	RYR1 RYR2	2.12e-05	4	66	2	23482488
Pubmed	Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction.	RYR1 RYR2	3.53e-05	5	66	2	22939628
Pubmed	Intracellular calcium-release channels: regulators of cell life and death.	RYR1 RYR2	3.53e-05	5	66	2	9124414
Pubmed	Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.	RYR1 RYR2	3.53e-05	5	66	2	23918386
Pubmed	Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.	RYR1 RYR2	3.53e-05	5	66	2	19011160
Pubmed	Genomic characterization of the lysophosphatidic acid receptor gene, lp(A2)/Edg4, and identification of a frameshift mutation in a previously characterized cDNA.	NPY1R MYO9B	3.53e-05	5	66	2	10729222
Pubmed	Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.	RYR1 RYR2	5.29e-05	6	66	2	19549818
Pubmed	Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.	RYR1 RYR2	5.29e-05	6	66	2	26025922
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR1 RYR2	5.29e-05	6	66	2	23463619
Pubmed	FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.	RYR1 RYR2	5.29e-05	6	66	2	14592808
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR1 RYR2	5.29e-05	6	66	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR1 RYR2	5.29e-05	6	66	2	25966694
Pubmed	Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas.	ATG7 PRKDC	5.29e-05	6	66	2	29153842
Pubmed	HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.	RYR1 RYR2	5.29e-05	6	66	2	19009018
Pubmed	Evidence for genetic control of microwave-induced augmentation of complement receptor-bearing B lymphocytes.	PDE6B HPS4	5.29e-05	6	66	2	6980940
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR1 RYR2	5.29e-05	6	66	2	16844763
Pubmed	Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.	ATG7 PRKDC	7.40e-05	7	66	2	24011591
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR1 RYR2	7.40e-05	7	66	2	11860456
Pubmed	Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.	RYR1 RYR2	7.40e-05	7	66	2	20962236
Pubmed	SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1).	DCUN1D1 DCUN1D3	9.86e-05	8	66	2	25349211
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	RYR1 RYR2	9.86e-05	8	66	2	19033399
Pubmed	Structural and functional studies of the early T lymphocyte activation 1 (Eta-1) gene. Definition of a novel T cell-dependent response associated with genetic resistance to bacterial infection.	PDE6B HPS4	9.86e-05	8	66	2	2787378
Pubmed	Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.	RYR1 RYR2	9.86e-05	8	66	2	11784029
Pubmed	Neuropeptide Y receptor genes on human chromosome 4q31-q32 map to conserved linkage groups on mouse chromosomes 3 and 8.	NPY1R MYO9B	9.86e-05	8	66	2	9169155
Pubmed	AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis.	RYR1 RYR2	1.58e-04	10	66	2	18434328
Pubmed	Real-time resolution of point mutations that cause phenovariance in mice.	MALT1 PRKDC	1.58e-04	10	66	2	25605905
Pubmed	The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.	LATS2 PRKDC	1.93e-04	11	66	2	15147269
Pubmed	Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA.	ATG7 PRKDC	1.93e-04	11	66	2	28973896
Pubmed	Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY.	NPY1R MYO9B	2.31e-04	12	66	2	9417917
Pubmed	New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.	RYR1 RYR2	2.31e-04	12	66	2	19095005
Pubmed	Card9 protects fungal peritonitis through regulating Malt1-mediated activation of autophagy in macrophage.	MALT1 PLEC	2.31e-04	12	66	2	35850054
Pubmed	An Airway Protection Program Revealed by Sweeping Genetic Control of Vagal Afferents.	NPY1R CRHR2	2.73e-04	13	66	2	32259485
Pubmed	MED12 regulates a transcriptional network of calcium-handling genes in the heart.	RYR1 RYR2	3.18e-04	14	66	2	28724790
Pubmed	RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways.	MAPK8IP1 PPP2R2C	3.18e-04	14	66	2	18626009
Pubmed	Diversified Application of Barcoded PLATO (PLATO-BC) Platform for Identification of Protein Interactions.	OTUB2 DCUN1D1	3.67e-04	15	66	2	31494268
Pubmed	Isolation and characterization of a novel H1.2 complex that acts as a repressor of p53-mediated transcription.	PURA PRKDC	4.18e-04	16	66	2	18258596
Pubmed	A vagal reflex evoked by airway closure.	NPY1R CRHR2	4.18e-04	16	66	2	38448588
Pubmed	Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer.	LATS2 PRKDC	4.18e-04	16	66	2	32730753
Pubmed	Conserved and Divergent Features of Human and Mouse Kidney Organogenesis.	SLC12A1 CUBN	4.74e-04	17	66	2	29449453
Pubmed	Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.	ATG7 PI4KA	4.74e-04	17	66	2	25327288
Pubmed	Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS.	SLC12A1 CUBN	4.74e-04	17	66	2	21082674
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PCNX2 MALT1 PPP2R2C LATS2 ATG7 INPP5A PURA CAB39L GRIK1 CSMD1	4.76e-04	1489	66	10	28611215
Pubmed	The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines.	FKBP6 DCUN1D1 DCUN1D2	5.19e-04	82	66	3	25260751
Pubmed	Ski regulates Hippo and TAZ signaling to suppress breast cancer progression.	LATS2 PRKDC PLEC	5.57e-04	84	66	3	25670202
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	MYO9B PI4KA PRKDC PLEC	6.01e-04	202	66	4	33005030
Cytoband	4q21	NPFFR2 SLC4A4	3.80e-04	20	66	2	4q21
Cytoband	22q11.21	PI4KAP1 PI4KA PI4KAP2	5.63e-04	111	66	3	22q11.21
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR1 RYR2	1.98e-05	3	47	2	287
GeneFamily	Neuropeptide receptors	NPFFR2 NPY1R	2.94e-04	10	47	2	854
GeneFamily	WD repeat domain containing\|Protein phosphatase 2 regulatory subunits	PPP2R2C PPP2R3C	6.80e-04	15	47	2	696
GeneFamily	EF-hand domain containing	GUCA1C SPATA21 NECAB3 RYR2	2.48e-03	219	47	4	863
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	C7 CSMD1	9.64e-03	57	47	2	1179
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	CSMD1 HYDIN RYR1	1.16e-02	181	47	3	694
Coexpression	FAN_EMBRYONIC_CTX_EX_4_EXCITATORY_NEURON	NPY1R PI4KAP2 PLEC CSMD1 HYDIN RYR2	3.91e-06	166	66	6	M39026
Coexpression	GSE5589_UNSTIM_VS_45MIN_LPS_AND_IL6_STIM_MACROPHAGE_DN	MALT1 INPP5A PI4KA PWP2 DCUN1D3 KAT14	1.14e-05	200	66	6	M6607
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26\|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.	MAPK8IP1 PPP2R2C NPY1R PLEC SLC4A4 RYR2	5.21e-07	200	66	6	61d7dd0a78942b069c3f5e75044368dc00e6e8e6
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	MAPK8IP1 PPP2R2C NPY1R PLEC SLC4A4 RYR2	5.21e-07	200	66	6	5c7263c862093ad9dbc81d06b16b6f74e8a6b634
ToppCell	facs-Marrow-B-cells-24m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APOBEC2 C7 CSMD1 HYDIN RYR2	6.20e-06	175	66	5	887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCell	343B-Lymphocytic-CD4_T-cell-Treg_cell_1\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	SIPA1L1 PURA ACP2 ZNF195 TFPI	8.34e-06	186	66	5	76cbc3610aedf8c19c17ad5faf6ef5e8980b6af5
Drug	AC1L380G	HPS4 RYR1 RYR2	2.08e-05	19	65	3	CID000084698
Drug	Leucomisine [17946-87-1]; Up 200; 16.2uM; MCF7; HT_HG-U133A	AMPD1 APOBEC2 ENTPD3 CUBN CRHR2 RYR1	2.22e-05	199	65	6	3546_UP
Drug	2-hydroxycarbazole	RYR1 RYR2	2.40e-05	3	65	2	CID000093551
Drug	cis-diammineplatinum(II	RYR1 RYR2	2.40e-05	3	65	2	CID000159790
Drug	2-hydroxyheptanoic acid	RYR1 RYR2	2.40e-05	3	65	2	CID002750949
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR1 RYR2	2.40e-05	3	65	2	CID005748312
Drug	8N3-cADPR	RYR1 RYR2	2.40e-05	3	65	2	CID000127713
Drug	aminodantrolene	RYR1 RYR2	2.40e-05	3	65	2	CID009570289
Drug	PCB74	RYR1 RYR2	4.80e-05	4	65	2	CID000036218
Drug	148504-47-6	RYR1 RYR2	4.80e-05	4	65	2	CID006444275
Drug	SC 38249	RYR1 RYR2	4.80e-05	4	65	2	CID000134834
Drug	AC1L1U7A	RYR1 RYR2	4.80e-05	4	65	2	CID000035682
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR1 RYR2	1.30e-05	3	62	2	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR1 RYR2	1.30e-05	3	62	2	DOID:8545 (implicated_via_orthology)
Disease	neurodegenerative disease (biomarker_via_orthology)	ATG7 GOT2	6.48e-05	6	62	2	DOID:1289 (biomarker_via_orthology)
Disease	Combined immunodeficiency	UNC119 MALT1 PRKDC	8.90e-05	41	62	3	C0494261
Disease	neurodegenerative disease (implicated_via_orthology)	UBR1 LATS2 SLC25A39 GRIK1	2.50e-04	145	62	4	DOID:1289 (implicated_via_orthology)
Disease	chromosome 22q11.2 deletion syndrome, distal (implicated_via_orthology)	PI4KA PI4KAP2	3.89e-04	14	62	2	DOID:0060413 (implicated_via_orthology)
Disease	Amphetamine-Related Disorders	NPY1R CUBN CSMD1	5.36e-04	75	62	3	C0236733
Disease	Amphetamine Abuse	NPY1R CUBN CSMD1	5.36e-04	75	62	3	C0236807
Disease	Amphetamine Addiction	NPY1R CUBN CSMD1	5.36e-04	75	62	3	C0236804
Disease	Lung diseases	HPS4 PRKDC CRHR2	6.01e-04	78	62	3	C0024115
Disease	lung cancer	GRIK1 CSMD1	8.89e-04	21	62	2	MONDO_0008903
Disease	coronary artery disease (is_implicated_in)	AMPD1 KIF6 CUBN	1.24e-03	100	62	3	DOID:3393 (is_implicated_in)
Disease	TEMPS-A questionnaire	CSMD1 SLC4A4	1.26e-03	25	62	2	EFO_0004783
Disease	congestive heart failure (is_implicated_in)	AMPD1 RYR1	1.47e-03	27	62	2	DOID:6000 (is_implicated_in)
Disease	level of Sphingomyelin (d42:2) in blood serum	NPFFR2 SLC4A4	1.70e-03	29	62	2	OBA_2045183
Disease	immature platelet fraction	MYO9B PLEC ARPC2	1.80e-03	114	62	3	EFO_0009187
Disease	level of Sphingomyelin (d38:1) in blood serum	NPFFR2 SLC4A4	1.82e-03	30	62	2	OBA_2045180
Disease	lifestyle measurement, alcohol consumption measurement	KIF6 PPP2R2C ENTPD3	1.84e-03	115	62	3	EFO_0007878, EFO_0010724
Disease	immature platelet measurement	MYO9B PLEC ARPC2	2.03e-03	119	62	3	EFO_0803541
Disease	level of Sphingomyelin (d40:1) in blood serum	NPFFR2 SLC4A4	2.07e-03	32	62	2	OBA_2045182

Protein segments in the cluster

Peptide	Gene	Start	Entry
FSNQFRDFFKYVELS	CAB39L	161	Q9H9S4
GAYNNFFRMFDRNTK	PPP2R2C	356	Q9Y2T4
FVVFGQFAYFQTALN	CSMD1	1661	Q96PZ7
FASVFEKYFQFQEEG	ARPC2	121	O15144
SRKNNDIEQAFCFFY	GRIK1	861	P39086
YVFVGRDFQEKFFQS	GPR32	316	O75388
RQTFQRFDKFNDKYN	AMPD1	366	P23109
LDYAQSRFQFYFQQK	CHKB	371	Q9Y259
YFKFFTTGENARIFQ	CACNG6	116	Q9BXT2
PGRFKDFYQFTFNFA	DCUN1D1	151	Q96GG9
EDKFKDLYRFTFQFG	DCUN1D3	176	Q8IWE4
FFKFQFRNVEYSSGR	APOBEC2	51	Q9Y235
QSYFKSQPFDFRGAQ	ENTPD3	161	O75355
GFFNENFRRGFQEAF	NPFFR2	436	Q9Y5X5
CEKFLQEVDFFQRYF	INTS4	751	Q96HW7
ENKGYLNVFSLNYFF	PPP2R3C	356	Q969Q6
DSNVKFFYLNGNFSF	OVOS1	441	Q6IE37
EEHKFRNFFNAFYSV	OTUB2	91	Q96DC9
GFYVCRVNNNFTFEF	MALT1	186	Q9UDY8
AFYEFTFRRFFDDNG	LATS2	1036	Q9NRM7
SVGRAFQQFYKQFVE	MAPK8IP1	686	Q9UQF2
KRFLDQLVGFFNFYN	HPS4	106	Q9NQG7
DFYQFTFTFAKNPGQ	DCUN1D2	156	Q6PH85
QGKFNREQFYKFIIF	PCNX2	801	A6NKB5
RFEKVSYFVFGDFNF	INPP5A	221	Q14642
FDYFNQEVFRDNNGT	INPP5A	286	Q14642
FLDQNPDFARQYFGK	PDE6B	11	P35913
EQLSYLKGDNFFRFT	KAT14	91	Q9H8E8
YNTFDTNKDGFVDFL	GUCA1C	61	O95843
IYFNSFLQSFQGFFV	CRHR2	341	Q13324
PAKDFYQREFDFFNK	PI4KA	1726	P42356
DFYQREFDFFNKITN	PI4KAP1	196	Q8N8J0
YKFKFQRIFDQDANQ	KIF6	56	Q6ZMV9
EYFGNFAFDKNSINI	MTPAP	446	Q9NVV4
GFLNKNFQRDLQFFF	NPY1R	321	P25929
KDFSFRFLFGIYQQA	ACP2	236	P11117
EFGNYLFRQNRFYDA	FKBP6	176	O75344
QAFGFDQTFQSYRKD	CFAP300	46	Q9BRQ4
NFYSNEQITDFGFKF	CUBN	3016	O60494
FYFQNDVKANTYFLE	HYDIN	2866	Q4G0P3
QYEREGFNFLAKVFN	ATG7	656	O95352
VDFEDNYQFAKYRSF	FCN2	196	Q15485
FVLDYFFEEKQNLRF	CPNE9	71	Q8IYJ1
YTFQVKINNDFNYEF	C7	186	P10643
DAQFFNYQRLFDFFN	MAN2A2	436	P49641
AFNFFRKFYNKSEDE	RYR1	4856	P21817
FNFFRKFYNKSEDGD	RYR2	4786	Q92736
EIYNLSANYFQEKFF	UTP4	41	Q969X6
KQEEAFRSYFEIFNG	SPATA21	221	Q7Z572
NEGVSYEFKFPFRNN	SIPA1L1	1051	O43166
RGFFNYQASIFAENF	SLC12A1	356	Q13621
DFYQRGFDFFNKITN	PI4KAP2	196	A4QPH2
RNLFAFFDMAYQGFA	GOT2	236	P00505
YFRNQLLKSFDFHFG	UNC119	166	Q13432
TDGFFIFNERFKNFT	TRIM13	376	O60858
YEFGKSFFQRLNQDR	SLC25A39	341	Q9BZJ4
RLAKYFFNKEGDFNN	PWP2	276	Q15269
EYLDRNNKFNFQGYS	UBR1	451	Q8IWV7
KENAAYFQFFSDVRE	PLEC	856	Q15149
YFQFFSDVREAEGQL	PLEC	861	Q15149
FYFRNDSEYRQFEGL	ZNF780A	116	O75290
FFNIFTRQCEEFIYG	TFPI	71	P10646
FEYFSETQRNKGNFP	TRBV5-1	66	A0A578
FNELKFYQGFLFSEK	PRKDC	1956	P78527
ERLLFNFSKDNNFDY	SLC4A4	536	Q9Y6R1
NFSKDNNFDYLEFRL	SLC4A4	541	Q9Y6R1
VDNKRFFFDVGSNKY	PURA	226	Q00577
FQYNKYVKIFDNFSN	ZNF195	216	O14628
DFERNSFEQFCINYA	MYO9B	526	Q13459
NDDGKLSFEEFQNYF	NECAB3	51	Q96P71