Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	animal organ morphogenesis	ASXL1 SEMA3C ALMS1 DLL4 SFTPB KCNQ4 WNT10B PKD1 APC LAMC2 MST1L STIL LZTS2 BCOR SIX3 BBS10 TLX1	1.38e-05	1269	85	17	GO:0009887
GeneOntologyBiologicalProcess	regulation of neural retina development	DLL4 SIX3	5.02e-05	3	85	2	GO:0061074
GeneOntologyBiologicalProcess	GDP-L-fucose biosynthetic process	FCSK GMDS	5.02e-05	3	85	2	GO:0042350
GeneOntologyBiologicalProcess	neural retina development	ALMS1 DLL4 POU4F2 SIX3 BBS10	6.42e-05	102	85	5	GO:0003407
GeneOntologyBiologicalProcess	GDP-L-fucose metabolic process	FCSK GMDS	1.00e-04	4	85	2	GO:0046368
Domain	ASX_HYDROXYL	FBLN7 CELSR3 DLL4 LRP1 LTBP2	7.39e-05	100	81	5	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	FBLN7 CELSR3 DLL4 LRP1 LTBP2	9.74e-05	106	81	5	IPR000152
Domain	EGF_1	FBLN7 CELSR3 DLL4 LRP1 LAMC2 LTBP2 SSPOP	1.20e-04	255	81	7	PS00022
Domain	EGF_2	FBLN7 CELSR3 DLL4 LRP1 LAMC2 LTBP2 SSPOP	1.52e-04	265	81	7	PS01186
Domain	EGF_CA	FBLN7 CELSR3 DLL4 LRP1 LTBP2	1.89e-04	122	81	5	SM00179
Domain	EGF-like_Ca-bd_dom	FBLN7 CELSR3 DLL4 LRP1 LTBP2	2.04e-04	124	81	5	IPR001881
Domain	EGF	FBLN7 CELSR3 DLL4 LRP1 LTBP2	2.19e-04	126	81	5	PF00008
Domain	EGF_3	FBLN7 CELSR3 DLL4 LRP1 LTBP2 SSPOP	5.50e-04	235	81	6	PS50026
Domain	EGF	FBLN7 CELSR3 DLL4 LRP1 LAMC2 LTBP2	5.50e-04	235	81	6	SM00181
Pubmed	The X-linked inhibitor of apoptosis protein (XIAP) is involved in melanoma invasion by regulating cell migration and survival.	ATXN2L FUBP1 PCBP1	9.61e-07	8	91	3	30778852
Pubmed	Ewing-like sarcoma: An emerging family of round cell sarcomas.	EWSR1 BCOR	6.77e-06	2	91	2	30257034
Pubmed	USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth.	EWSR1 USP19	6.77e-06	2	91	2	30700749
Pubmed	Delta-like 4/Notch signaling promotes Apc Min/+ tumor initiation through angiogenic and non-angiogenic related mechanisms.	DLL4 APC	6.77e-06	2	91	2	28086833
Pubmed	Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951.	STIL TLX1	2.03e-05	3	91	2	14504110
Pubmed	Recurrent BCOR Internal Tandem Duplication and YWHAE-NUTM2B Fusions in Soft Tissue Undifferentiated Round Cell Sarcoma of Infancy: Overlapping Genetic Features With Clear Cell Sarcoma of Kidney.	NUTM2B BCOR	2.03e-05	3	91	2	26945340
Pubmed	A family of tissue-specific resistin-like molecules.	RETNLB APC	2.03e-05	3	91	2	11209052
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	CELSR3 ALMS1 CTR9 SSPOP BAHCC1	2.43e-05	130	91	5	12421765
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ZNF512B CELSR3 CTR9 PKD1 LRP1 APC EWSR1 CABIN1 PCBP1 AKAP8L SNX1 MAPK8IP2 SH3BP5	2.97e-05	1285	91	13	35914814
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZNF512B FCSK EDEM3 ALMS1 RTL9 LRP1 IRS2 LZTS2 BCOR PSMG3-AS1 AKAP8L BAHCC1	3.44e-05	1116	91	12	31753913
Pubmed	In vivo phenotypic and molecular characterization of retinal degeneration in mouse models of three ciliopathies.	ALMS1 BBS10	4.05e-05	4	91	2	31302159
Pubmed	LRP1 induces anti-PD-1 resistance by modulating the DLL4-NOTCH2-CCL2 axis and redirecting M2-like macrophage polarisation in bladder cancer.	DLL4 LRP1	4.05e-05	4	91	2	38462037
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	ATXN2L ALMS1 WDR33 EWSR1 BCOR	5.13e-05	152	91	5	38360978
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	ATXN2L KIF23 CTR9 FUBP1 APC IRS2 PCBP1 SH3BP5	5.38e-05	503	91	8	16964243
Pubmed	V(D)J recombinase binding and cleavage of cryptic recombination signal sequences identified from lymphoid malignancies.	STIL TLX1	6.74e-05	5	91	2	18187418
Pubmed	A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis.	SEMA3C SEMA3B	6.74e-05	5	91	2	8817451
Pubmed	The emergence of transcriptional identity in somatosensory neurons.	AVPR1A POU4F2	6.74e-05	5	91	2	31915380
Pubmed	Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels.	SEMA3C DLL4 SEMA3B	7.39e-05	31	91	3	22076636
Pubmed	A neurogenomics approach to gene expression analysis in the developing brain.	SEMA3C FUBP1 PKD1 SPPL3 BAHCC1	8.71e-05	170	91	5	15582152
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	ATXN2L KIF23 ALMS1 WDR33 LZTS2 BCOR PCBP1 SNX1	9.88e-05	549	91	8	38280479
Pubmed	Expression of class 3 semaphorins and neuropilin receptors in the developing mouse tooth.	SEMA3C SEMA3B	1.01e-04	6	91	2	11231073
Pubmed	Axonal wiring of guanylate cyclase-D-expressing olfactory neurons is dependent on neuropilin 2 and semaphorin 3F.	SEMA3C SEMA3B	1.01e-04	6	91	2	17942483
Pubmed	Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension.	SEMA3C SEMA3B	1.01e-04	6	91	2	7748561
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	ALMS1 LRP1 STIL LZTS2 BCOR	1.26e-04	184	91	5	32908313
Pubmed	Direct recruitment of H+-ATPase from lysosomes for phagosomal acidification.	RAB5A SNX1	1.41e-04	7	91	2	19549681
Pubmed	Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein.	FUBP1 SIX3	1.41e-04	7	91	2	18836447
Pubmed	Low Density Lipoprotein-Receptor Related Protein 1 Is Differentially Expressed by Neuronal and Glial Populations in the Developing and Mature Mouse Central Nervous System.	LRP1 APC	1.88e-04	8	91	2	27280679
Pubmed	The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting.	RAB5A SNX1	1.88e-04	8	91	2	22431521
Pubmed	Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells.	CACNA2D2 SEMA3B	1.88e-04	8	91	2	11487633
Pubmed	Semaphorins III and IV repel hippocampal axons via two distinct receptors.	SEMA3C SEMA3B	1.88e-04	8	91	2	9753685
Pubmed	Protocadherin Celsr3 is crucial in axonal tract development.	CELSR3 SFTPB	1.88e-04	8	91	2	15778712
Pubmed	Development of the somatosensory cortex, the cerebellum, and the main olfactory system in Semaphorin 3F knockout mice.	SEMA3C SEMA3B	1.88e-04	8	91	2	20006658
Pubmed	Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal convergence, of primary accessory olfactory neurons.	SEMA3C SEMA3B	1.88e-04	8	91	2	11906695
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ATXN2L KIF23 CTR9 FUBP1 IRS2 BCOR PCBP1 AKAP8L USP19	1.97e-04	774	91	9	15302935
Pubmed	The sensory innervation of the mouse spinal cord may be patterned by differential expression of and differential responsiveness to semaphorins.	SEMA3C SEMA3B	2.41e-04	9	91	2	8812066
Pubmed	Plk4 Promotes Cancer Invasion and Metastasis through Arp2/3 Complex Regulation of the Actin Cytoskeleton.	ALMS1 APC STIL	2.75e-04	48	91	3	27872092
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	ZNF512B KIF23 ALMS1 WDR33 CABIN1 RAB5A SNX1 KIF22	2.95e-04	645	91	8	25281560
Pubmed	Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance.	LRP1 RAB5A	3.01e-04	10	91	2	26005850
Pubmed	Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength.	ASXL1 MIGA2	3.01e-04	10	91	2	22876197
Pubmed	BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.	ALMS1 RTL9 APC IRS2 RAB5A	3.27e-04	226	91	5	25900982
Pubmed	Class 3 semaphorins negatively regulate dermal lymphatic network formation.	SEMA3C SEMA3B	3.67e-04	11	91	2	26319580
Pubmed	Delta-like ligand 4-mediated Notch signaling controls proliferation of second heart field progenitor cells by regulating Fgf8 expression.	SEMA3C DLL4	3.67e-04	11	91	2	32778568
Pubmed	Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.	SIX3 SH3BP5	3.67e-04	11	91	2	22488850
Pubmed	Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference.	KIF23 KIF22	3.67e-04	11	91	2	15843429
Pubmed	Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye.	POU4F2 SIX3	3.67e-04	11	91	2	11069887
Pubmed	Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting.	SEMA3C SEMA3B	4.39e-04	12	91	2	19812329
Pubmed	Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos.	RAB5A SNX1	4.39e-04	12	91	2	22990867
Pubmed	Deletion of Sema3a or plexinA1/plexinA3 causes defects in sensory afferent projections of statoacoustic ganglion neurons.	SEMA3C SEMA3B	4.39e-04	12	91	2	23991118
Pubmed	Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo.	APC SIX3	4.39e-04	12	91	2	12645927
Pubmed	Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos.	CTR9 AKAP3 BCOR	4.82e-04	58	91	3	27869233
Pubmed	Role of neuropilin-2 in the ipsilateral growth of midbrain dopaminergic axons.	SEMA3C SEMA3B	5.18e-04	13	91	2	23534961
Pubmed	Cell-autonomous involvement of Mab21l1 is essential for lens placode development.	POU4F2 SIX3	6.04e-04	14	91	2	12642482
Pubmed	The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation.	SEMA3C SEMA3B	6.04e-04	14	91	2	22955271
Pubmed	FOXO1-mediated activation of Akt plays a critical role in vascular homeostasis.	DLL4 IRS2	6.04e-04	14	91	2	24874427
Pubmed	Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses.	LRP1 HCK	6.04e-04	14	91	2	26453377
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	ATXN2L WDR33 FUBP1 EWSR1 BCOR PCBP1	6.44e-04	399	91	6	35987950
Pubmed	Dlx1 and Dlx2 function is necessary for terminal differentiation and survival of late-born retinal ganglion cells in the developing mouse retina.	POU4F2 SIX3	6.95e-04	15	91	2	15604100
Pubmed	Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.	CELSR3 SSPOP	6.95e-04	15	91	2	20473291
Pubmed	The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium.	CACNA2D2 SEMA3B	6.95e-04	15	91	2	11085536
Pubmed	Expression of the semaphorins Sema 3D and Sema 3F in the developing parathyroid and thymus.	SEMA3C SEMA3B	7.93e-04	16	91	2	18489001
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ALMS1 LRP1 APC IRS2 BCOR AKAP8L	8.20e-04	418	91	6	34709266
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	ZNF512B ATXN2L KIF23 NUTM2B WDR33 FUBP1 EWSR1 BCOR PCBP1	8.90e-04	954	91	9	36373674
Pubmed	Semaphorin signaling facilitates cleft formation in the developing salivary gland.	SEMA3C SEMA3B	8.98e-04	17	91	2	17626059
Pubmed	Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.	DLL4 LY75	8.98e-04	17	91	2	23362346
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	ATXN2L ALMS1 WDR33 CTR9 APC LZTS2 BCOR	9.06e-04	588	91	7	38580884
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	KIF23 LRP1 APC EWSR1 BCOR CABIN1 PCBP1 MAPK8IP2 SH3BP5	9.51e-04	963	91	9	28671696
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	SEMA3C SFTPB LAMC2 LTBP2	9.90e-04	167	91	4	22159717
Pubmed	Assignment of 22 loci in the rat by somatic hybrid and linkage analysis.	APC MST1L	1.01e-03	18	91	2	8268657
Pubmed	Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.	LRP1 MAPK8IP2	1.01e-03	18	91	2	10827173
Pubmed	Neuropilin-2/Semaphorin-3F-mediated repulsion promotes inner hair cell innervation by spiral ganglion neurons.	SEMA3C SEMA3B	1.01e-03	18	91	2	26302206
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	ATXN2L NUTM2B EWSR1 LZTS2 BCOR PCBP1 SSPOP	1.10e-03	608	91	7	16713569
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	FCSK DLL4 NOX5 C17orf99 RETNLB SPPL3 GPR78 ADAMTS13 MTCH1	1.11e-03	985	91	9	12975309
Pubmed	Expression of a Constitutively Active Form of Hck in Chondrocytes Activates Wnt and Hedgehog Signaling Pathways, and Induces Chondrocyte Proliferation in Mice.	WNT10B HCK	1.12e-03	19	91	2	32290615
Pubmed	FGF signaling regulates development by processes beyond canonical pathways.	IRS2 SIX3	1.12e-03	19	91	2	33184218
Pubmed	Segmental variations in trabecular bone density and microstructure of the spine in senescence-accelerated mouse (SAMP6): a murine model for senile osteoporosis.	WNT10B HCK	1.12e-03	19	91	2	22342532
Pubmed	Neurites from trigeminal ganglion explants grown in vitro are repelled or attracted by tooth-related tissues depending on developmental stage.	SEMA3C SEMA3B	1.12e-03	19	91	2	15051154
Pubmed	Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.	KIF23 CTR9 EWSR1 AKAP8L	1.23e-03	177	91	4	26206133
Pubmed	VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm.	SEMA3C SEMA3B	1.25e-03	20	91	2	21658587
Pubmed	A Wnt-bmp feedback circuit controls intertissue signaling dynamics in tooth organogenesis.	WNT10B APC	1.25e-03	20	91	2	22234613
Pubmed	Tbx1 coordinates addition of posterior second heart field progenitor cells to the arterial and venous poles of the heart.	SEMA3C LTBP2	1.25e-03	20	91	2	25190705
Pubmed	Human transcription factor protein interaction networks.	ZNF512B ASXL1 KIF23 ALMS1 WDR33 FUBP1 EWSR1 BCOR CABIN1 AKAP8L TLX1	1.26e-03	1429	91	11	35140242
Pubmed	Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence.	DLL4 LY75	1.38e-03	21	91	2	22072979
Pubmed	Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity.	SEMA3C SEMA3B	1.38e-03	21	91	2	36240771
Pubmed	Blood flow controls bone vascular function and osteogenesis.	DLL4 WNT10B	1.51e-03	22	91	2	27922003
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	ATXN2L KIF23 WDR33 APC EWSR1 LZTS2 PCBP1 AKAP8L KIF22 ADSS1	1.57e-03	1247	91	10	27684187
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SEMA3C CTR9 APC LAMC2 EWSR1 MAP3K6 AKAP8L	1.61e-03	650	91	7	38777146
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	ASXL1 CELSR3 PKD1 LTBP2 KIF22	1.76e-03	329	91	5	17474147
Pubmed	Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human.	LRP1 SNX1	1.80e-03	24	91	2	17452356
Pubmed	Loss of semaphorin-neuropilin-1 signaling causes dysmorphic vascularization reminiscent of alveolar capillary dysplasia.	SEMA3C SFTPB	1.80e-03	24	91	2	23063659
Pubmed	A semaphorin code defines subpopulations of spinal motor neurons during mouse development.	SEMA3C SEMA3B	1.80e-03	24	91	2	15869472
Pubmed	Gene network analysis in a pediatric cohort identifies novel lung function genes.	WDR33 PSD3	1.80e-03	24	91	2	24023788
Pubmed	Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA.	ASXL1 RETNLB PKD1 TM4SF5	1.85e-03	198	91	4	27480124
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ATXN2L KIF23 ALMS1 PSD3 APC IRS2 STIL MAP3K6	1.90e-03	861	91	8	36931259
Pubmed	Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development.	SEMA3C WNT10B	1.95e-03	25	91	2	21784065
Pubmed	Rheb1 is required for mTORC1 and myelination in postnatal brain development.	APC IRS2	1.95e-03	25	91	2	21238928
Pubmed	Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer.	RAB5A SNX1	1.95e-03	25	91	2	15078902
Pubmed	Holoprosencephaly Overview	STIL SIX3	1.95e-03	25	91	2	20301702
Pubmed	Spatial restriction of bone morphogenetic protein signaling in mouse gastrula through the mVam2-dependent endocytic pathway.	SIX3 SNX1	1.95e-03	25	91	2	22698281
Pubmed	Dll1 and Dll4 function sequentially in the retina and pV2 domain of the spinal cord to regulate neurogenesis and create cell diversity.	DLL4 POU4F2	1.95e-03	25	91	2	19389377
Pubmed	Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways.	APC IRS2	1.95e-03	25	91	2	18992263
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	CELSR3 CACNA2D2 SEMA3B USP19 INKA1	4.29e-04	316	91	5	chr3p21
Cytoband	3p21.31	CELSR3 USP19 INKA1	1.06e-03	100	91	3	3p21.31
Cytoband	10q24	LZTS2 TLX1	2.22e-03	35	91	2	10q24
Drug	Dimethisoquin hydrochloride [2773-92-4]; Up 200; 13uM; MCF7; HT_HG-U133A	PSD3 LRP1 APC IRS2 ASIC4 SIX3 SNX1	1.01e-05	191	89	7	4791_UP
Drug	Guaifenesin [93-14-1]; Down 200; 20.2uM; MCF7; HT_HG-U133A	EDEM3 ALMS1 FUBP1 SEMA3B SETD4 IRS2 CABIN1	1.12e-05	194	89	7	3431_DN
Drug	Harmalol hydrochloride dihydrate [6028-07-5]; Up 200; 14.6uM; MCF7; HT_HG-U133A	CACNA2D2 C10orf95 SETD4 LAMC2 POU4F2 SIX3 BRF2	1.23e-05	197	89	7	5495_UP
Drug	haloperidol; Down 200; 10uM; MCF7; HT_HG-U133A	CELSR3 WDR33 FUBP1 APC C10orf95 SETD4 BCOR	1.28e-05	198	89	7	7003_DN
Drug	Thiocolchicoside [602-41-5]; Up 200; 7uM; MCF7; HT_HG-U133A	WDR33 TM4SF5 IRS2 CABIN1 MAP3K6 AKAP8L BRF2	1.28e-05	198	89	7	5520_UP
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	ALMS1 SFTPB FUBP1 APC TM4SF5 MAPK8IP2 BRF2	1.28e-05	198	89	7	4348_DN
Drug	Mefenamic acid [61-68-7]; Up 200; 16.6uM; MCF7; HT_HG-U133A	SFTPB WNT10B APC LAMC2 POU4F2 IRS2 CABIN1	1.32e-05	199	89	7	5534_UP
Drug	Methyl benzethonium chloride [25155-18-4]; Up 200; 8.6uM; MCF7; HT_HG-U133A	ATXN2L SFTPB APC LAMC2 IRS2 SARDH	7.35e-05	179	89	6	6045_UP
Drug	Leflunomide [75706-12-6]; Down 200; 14.8uM; MCF7; HT_HG-U133A	ATXN2L CACNA2D2 WNT10B LAMC2 LTBP2 BAHCC1	1.08e-04	192	89	6	6102_DN
Drug	Equilin [474-86-2]; Up 200; 15uM; MCF7; HT_HG-U133A	ATXN2L SFTPB SEMA3B APC ASIC4 SH3BP5	1.08e-04	192	89	6	5620_UP
Drug	Pivampicillin [33817-20-8]; Down 200; 8.6uM; MCF7; HT_HG-U133A	EDEM3 ALMS1 SEMA3B APC C10orf95 BAHCC1	1.14e-04	194	89	6	3506_DN
Drug	Glycopyrrolate [596-51-0]; Up 200; 10uM; MCF7; HT_HG-U133A	ATXN2L APC LAMC2 IRS2 SIX3 USP19	1.14e-04	194	89	6	4709_UP
Drug	Equilin [474-86-2]; Down 200; 15uM; MCF7; HT_HG-U133A	ATXN2L EDEM3 ALMS1 PSD3 APC C10orf95	1.14e-04	194	89	6	3377_DN
Drug	Dihydroergotoxine mesylate [8067-24-1]; Up 200; 6.4uM; MCF7; HT_HG-U133A	CACNA2D2 SFTPB SEMA3B IRS2 CABIN1 USP19	1.21e-04	196	89	6	2793_UP
Drug	Flupentixol dihydrochloride cis-(Z) [2413-38-9]; Up 200; 7.8uM; MCF7; HT_HG-U133A	ATXN2L SEMA3B PSD3 EWSR1 IRS2 LTBP2	1.21e-04	196	89	6	5307_UP
Drug	Iodipamide [606-17-7]; Up 200; 3.6uM; MCF7; HT_HG-U133A	ATXN2L IRS2 LTBP2 ADAMTS13 SIX3 MAP3K6	1.21e-04	196	89	6	5510_UP
Drug	Parbendazole [14255-87-9]; Down 200; 16.2uM; MCF7; HT_HG-U133A	WDR33 C10orf95 SETD4 LTBP2 CABIN1 USP19	1.21e-04	196	89	6	3881_DN
Drug	9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2; Up 200; 10uM; MCF7; HT_HG-U133A	CELSR3 ALMS1 IRS2 LTBP2 ADAMTS13 BAHCC1	1.24e-04	197	89	6	7500_UP
Drug	2-propylpentanoic acid; Down 200; 50uM; MCF7; HT_HG-U133A	ZNF512B ATXN2L CELSR3 ALMS1 MAP3K6 BBS10	1.24e-04	197	89	6	6941_DN
Drug	Dropropizine (R,S) [17692-31-8]; Up 200; 17uM; PC3; HT_HG-U133A	ALMS1 SFTPB LRP1 APC LAMC2 SIX3	1.24e-04	197	89	6	5106_UP
Drug	alpha-estradiol; Down 200; 0.01uM; HL60; HT_HG-U133A	ATXN2L WDR33 PSD3 GMDS CABIN1 BRF2	1.24e-04	197	89	6	6169_DN
Drug	Quipazine dimaleate salt [4774-24-7]; Up 200; 9uM; MCF7; HT_HG-U133A	ATXN2L ALMS1 SFTPB PSD3 APC BAHCC1	1.24e-04	197	89	6	2782_UP
Drug	Diloxanide furoate [3736-81-0]; Down 200; 12.2uM; MCF7; HT_HG-U133A	ALMS1 SFTPB LAMC2 IRS2 CABIN1 USP19	1.24e-04	197	89	6	5025_DN
Drug	Capsaicin [404-86-4]; Down 200; 13uM; MCF7; HT_HG-U133A	ATXN2L CACNA2D2 WDR33 PSD3 APC CABIN1	1.24e-04	197	89	6	3372_DN
Drug	Arcaine sulfate [14923-17-2]; Down 200; 14.8uM; PC3; HT_HG-U133A	EDEM3 SFTPB LRP1 APC SETD4 SIX3	1.24e-04	197	89	6	6629_DN
Drug	Iopromide [73334-07-3]; Down 200; 5uM; MCF7; HT_HG-U133A	ATXN2L CACNA2D2 SFTPB PSD3 C10orf95 ADAMTS13	1.24e-04	197	89	6	6842_DN
Drug	Trimethylcolchicinic acid [3482-37-9]; Up 200; 11.6uM; MCF7; HT_HG-U133A	CACNA2D2 IRS2 LTBP2 CABIN1 MAPK8IP2 BAHCC1	1.24e-04	197	89	6	2802_UP
Drug	Acebutolol hydrochloride [34381-68-5]; Down 200; 10.8uM; MCF7; HT_HG-U133A	SFTPB APC SETD4 CABIN1 MAPK8IP2 BRF2	1.28e-04	198	89	6	4976_DN
Drug	Naloxone hydrochloride [357-08-4]; Down 200; 11uM; MCF7; HT_HG-U133A	SFTPB BCOR CABIN1 MAP3K6 SNX1 BRF2	1.28e-04	198	89	6	1506_DN
Drug	Condelphine [7633-69-4]; Up 200; 8.8uM; HL60; HT_HG-U133A	C10orf95 LAMC2 SLC15A3 SIX3 C3orf36 BAHCC1	1.28e-04	198	89	6	2976_UP
Drug	(-)-Quinpirole hydrochloride [85760-74-3]; Up 200; 15.6uM; MCF7; HT_HG-U133A	CELSR3 SEMA3B APC IRS2 MAP3K6 USP19	1.28e-04	198	89	6	7481_UP
Drug	Danazol [17230-88-5]; Up 200; 11.8uM; MCF7; HT_HG-U133A	SFTPB PSD3 C10orf95 LAMC2 IRS2 ADAMTS13	1.28e-04	198	89	6	1538_UP
Drug	Spaglumic acid [4910-46-7]; Up 200; 13.2uM; MCF7; HT_HG-U133A	CELSR3 SFTPB SEMA3B PSD3 APC IRS2	1.32e-04	199	89	6	7465_UP
Drug	CP-690334-01 [459212-38-5]; Down 200; 1uM; PC3; HT_HG-U133A	WNT10B SEMA3B APC LAMC2 USP19 MAPK8IP2	1.32e-04	199	89	6	4561_DN
Disease	Clear Cell Sarcoma of Soft Tissue	EWSR1 BCOR	5.26e-05	4	88	2	C0206651
Disease	serum gamma-glutamyl transferase measurement	SFTPB FAM53A PKD1 SPPL3 PSD3 TM4SF5 PERM1 LZTS2 CABIN1 CSMD3 BAHCC1	8.63e-05	914	88	11	EFO_0004532
Disease	Clear cell sarcoma of kidney	NUTM2B BCOR	1.31e-04	6	88	2	C0334488
Disease	hepatocyte growth factor-like protein measurement	CELSR3 CACNA2D2 USP19	2.00e-04	38	88	3	EFO_0008154
Disease	N-acetylglutamine measurement	ALMS1 PSD3	6.71e-04	13	88	2	EFO_0800017
Disease	Bardet-Biedl Syndrome	ALMS1 BBS10	6.71e-04	13	88	2	C0752166
Disease	taste liking measurement	ATXN2L CACNA2D2 AVPR1A SIX3 LY75 CSMD3	1.09e-03	388	88	6	EFO_0010155
Disease	cervical artery dissection	LRP1 IRAG1	1.16e-03	17	88	2	EFO_1000059
Disease	blood metabolite measurement	ALMS1 SARDH	1.45e-03	19	88	2	EFO_0005664
Disease	colorectal cancer, inflammatory bowel disease	ALMS1 KCNQ4	1.45e-03	19	88	2	EFO_0003767, MONDO_0005575
Disease	Anophthalmia-microphthalmia syndrome	BCOR SIX3	1.78e-03	21	88	2	cv:C5680330
Disease	dilated cardiomyopathy (implicated_via_orthology)	DLL4 LTBP2 MTCH1	1.78e-03	80	88	3	DOID:12930 (implicated_via_orthology)
Disease	Glioma	FUBP1 PSD3 APC	2.27e-03	87	88	3	C0017638

Protein segments in the cluster

Peptide	Gene	Start	Entry
SGPGENRSMSGPDNR	EWSR1	286	Q01844
MLGRPGTGVVTSGRC	BAHCC1	306	Q9P281
TACRDPGVPMNGTRN	CSMD3	1526	Q7Z407
SCSQARTMNPGGSGG	C2orf69	26	Q8N8R5
RTMNPGGSGGARCSL	C2orf69	31	Q8N8R5
MAVPARTCGASRPGP	CACNA2D2	1	Q9NY47
RRSSAMGPRGCGVGA	SH3BP5	261	O60239
PCAFRSAGPSEMTRG	ALMS1	2601	Q8TCU4
GPSRMCRCRPGFTGT	DLL4	421	Q9NR61
IPQQRSSSCPRMGGT	BCOR	536	Q6W2J9
SSSMPAGCVLPVGGN	BBS10	591	Q8TAM1
VLTCLSAPSGPGGMA	C3orf36	31	Q3SXR2
LGLGGSCPPMRESDT	ASXL1	866	Q8IXJ9
TRCMPSGPREDGTLS	ADAMTS13	506	Q76LX8
SEARGINGGPSRMSP	ATXN2L	396	Q8WWM7
GARGQCMSGASRLPS	AKAP8L	206	Q9ULX6
MASRGATRPNGPNTG	RAB5A	1	P20339
DPAQTGPEGCRGTMS	NOX5	6	Q96PH1
RMATASAPGRAGPNS	FBLN7	356	Q53RD9
CGRDTGSPSMPGPLQ	INKA1	21	Q96EL1
MPASSPVICAGGQDR	PCBP1	186	Q15365
MGSVSSLISGRPCPG	LZTS2	26	Q9BRK4
RPRRGCGDSGSSGMA	PSMG3-AS1	66	Q96PY0
MAHAPARCPSARGSG	GMDS	1	O60547
PGAASSMSCSQPGQR	MST1L	11	Q2TV78
GGLPERSCMLTGTPE	FUBP1	141	Q96AE4
RNGGTCAASPSGMPT	LRP1	4241	Q07954
MQPCERSAAGGSGGR	FAM43B	121	Q6ZT52
MSEAGGRGCGSPVPQ	EDEM3	1	Q9BZQ6
SRMISEGSSPIRCPG	MAPK8IP2	356	Q13387
PGSTSFCPGESSRMG	KCNQ4	421	P56696
FCVASGNGRPDSGMP	KIAA1614	1146	Q5VZ46
CGPSEDGVPRTARSM	IRAG1	661	Q9Y6F6
MAGPCPRSGAERAGS	MAP3K6	1	O95382
MGSRPPCGATSSARR	LENG9	1	Q96B70
GTAGASDPPCVRGMD	KIF22	56	Q14807
RPSAPTIGGSSCARM	LY75	306	O60449
SVGQRGDSGSTPMPR	MIGA2	196	Q7L4E1
GDSGSTPMPRDGLRN	MIGA2	201	Q7L4E1
NADPRSSLPSRAGGM	ASIC4	206	Q96FT7
GVMRGRTPSAPGACQ	GPR78	66	Q96P69
SVGRCSMPEGPFPGR	PCDHB16	721	Q9NRJ7
CPGSGGSPMRRETSA	IRS2	1231	Q9Y4H2
QGRPSSCPAGMAVTG	RETNLB	61	Q9BQ08
CMAEGRGGLRSGPAA	FCSK	616	Q8N0W3
MGGRSSCEDPGCPRD	HCK	1	P08631
GPRVEMICQASSGSP	C17orf99	141	Q6UX52
GRSSAVSPRNCPAGM	CABIN1	561	Q9Y6J0
PPRTRMDSSGLGPCS	DOCK8-AS1	86	Q5T8R8
RTNPGCPAEVRLGMG	CTR9	191	Q6PD62
MPGRGRCPDCGSTEL	BRF2	1	Q9HAW0
CRPRGAGGQSMSEAP	LTBP2	1386	Q14767
PGMAARDSQCTSGPS	GPR156	436	Q8NFN8
NPMGSEPVGCRSDGT	LAMC2	576	Q13753
PMASRGLAGGCQAPQ	C2orf50	36	Q96LR7
LSRPGSQECMDAAPG	CELSR3	3096	Q9NYQ7
MRCGESGAGPDPRSN	DNAJC9-AS1	56	A6NH13
GRSSFCGEMPASPLG	SLC15A3	126	Q8IY34
SSCPGPASSGDQMQR	PERM1	126	Q5SV97
DNRTQLAPACMPGGR	PKD1	631	P98161
TMTGSPGEGGLLPRC	KIF23	121	Q02241
TCPPQMTARDSQGRG	NUTM2B	671	A6NNL0
PAAQPSARRMDGGSG	MTCH1	56	Q9NZJ7
SGDMCTLPVRAPASG	RTL9	881	Q8NET4
MSGTRASNDRPPGAG	ADSS1	1	Q8N142
GTCPGGAFTPNMRTT	SEMA3C	376	Q99985
VLTMPTLSGQGCRGP	SSPOP	3841	A2VEC9
RCSMDDSAGPRSPTG	SFTPB	276	P07988
GGGSEAMRRACLPTP	POU4F2	81	Q12837
GPSGMRSLAEPGCPT	SIX3	276	O95343
APACFPGTGRGLMSQ	SETD4	51	Q9NVD3
RQSPTRGMGPCNLSS	SARDH	16	Q9UL12
RGMGPCNLSSAAGPT	SARDH	21	Q9UL12
MRGTSGQPPEGCAAP	AKAP3	741	O75969
RSGECSPVPMGSFPR	APC	106	P25054
SRPTASAAGPGACMR	C10orf95	81	Q9H7T3
SAAGPGACMRASGRP	C10orf95	86	Q9H7T3
MQQEGGPVRSAPCRT	SHF	1	Q7M4L6
SPIALRPQGDMGSCS	STIL	661	Q15468
QPGRMALESQSPGCT	USP19	876	O94966
SERSQRMPLPGDSGC	TEX13D	316	A0A0J9YY54
MASGGGGCSASERLP	SNX1	1	Q13596
GGSANSLRMCRPQPA	SEMA3B	701	Q13214
SCGAPGPANISGRMQ	SPPL3	296	Q8TCT6
GMSSPGCDRRSPTLS	SPOCD1	171	Q6ZMY3
GRGPSPRSEMNSSVG	nan	26	Q7L0L9
GLGSMPSSSCGPRSR	RPP25L	141	Q8N5L8
MRLSAGPDAGPSGNS	AVPR1A	1	P37288
MGPCSNGEAASTSRP	nan	71	A8MV72
MTDPFCVGGRRLPGS	ZNF512B	1	Q96KM6
NSPDQGGCMGPASRL	TLX1	26	P31314
TLPGVGPCESSMRGE	ZNF443	96	Q9Y2A4
SVSGAGLRNGPRCLM	TM4SF5	106	O14894
DPTMGSPGTRGRACN	WNT10B	321	O00744
GSNMNSGPPRRGASR	WDR33	1316	Q9C0J8
PGGCDRSSSMGRPGR	PSD3	281	Q9NYI0
LSTGPRGLCAMPQTG	VENTX	241	O95231
DSRGLPGITMPGCSQ	FAM53A	326	Q6NSI3
PGITMPGCSQRGLRT	FAM53A	331	Q6NSI3