Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	SH3 domain binding	AFAP1L2 BCAR1 KHDRBS3 AFAP1L1	2.99e-04	143	45	4	GO:0017124
GeneOntologyMolecularFunction	cadherin binding involved in cell-cell adhesion	CDH9 CNN3	8.29e-04	19	45	2	GO:0098641
GeneOntologyMolecularFunction	serine-type endopeptidase activity	PCSK1 PCSK2 PCSK4 PCSK6	8.72e-04	190	45	4	GO:0004252
GeneOntologyMolecularFunction	microtubule plus-end binding	DST CLASP1	1.11e-03	22	45	2	GO:0051010
GeneOntologyMolecularFunction	serine-type peptidase activity	PCSK1 PCSK2 PCSK4 PCSK6	1.20e-03	207	45	4	GO:0008236
GeneOntologyMolecularFunction	serine hydrolase activity	PCSK1 PCSK2 PCSK4 PCSK6	1.31e-03	212	45	4	GO:0017171
GeneOntologyBiologicalProcess	peptide hormone processing	PCSK1 PCSK2 PCSK4 PCSK6	2.06e-06	41	46	4	GO:0016486
GeneOntologyBiologicalProcess	signaling receptor ligand precursor processing	PCSK1 PCSK2 PCSK4 PCSK6	3.30e-06	46	46	4	GO:0140448
GeneOntologyBiologicalProcess	protein processing	MYC PCSK1 PCSK2 IFT88 PCSK4 PCSK6	3.89e-05	285	46	6	GO:0016485
GeneOntologyBiologicalProcess	response to blue light	TYR CPT1B	7.26e-05	6	46	2	GO:0009637
GeneOntologyCellularComponent	anchoring junction	ILDR2 FAT1 PEAK1 DST BCAR1 CLASP1 CDH9 CNN3 AFAP1L1	2.35e-04	976	46	9	GO:0070161
GeneOntologyCellularComponent	focal adhesion	FAT1 PEAK1 DST BCAR1 CLASP1 CNN3	3.46e-04	431	46	6	GO:0005925
GeneOntologyCellularComponent	cell-substrate junction	FAT1 PEAK1 DST BCAR1 CLASP1 CNN3	4.00e-04	443	46	6	GO:0030055
Domain	Peptidase_S8_Asp-AS	PCSK1 PCSK2 PCSK4 PCSK6	4.81e-10	6	46	4	IPR023827
Domain	PrprotnconvertsP	PCSK1 PCSK2 PCSK4 PCSK6	1.12e-09	7	46	4	IPR002884
Domain	P_proprotein	PCSK1 PCSK2 PCSK4 PCSK6	1.12e-09	7	46	4	PF01483
Domain	S8_pro-domain	PCSK1 PCSK2 PCSK4 PCSK6	1.12e-09	7	46	4	IPR032815
Domain	-	PCSK1 PCSK2 PCSK4 PCSK6	1.12e-09	7	46	4	3.30.70.850
Domain	S8_pro-domain	PCSK1 PCSK2 PCSK4 PCSK6	1.12e-09	7	46	4	PF16470
Domain	Peptidase_S8_His-AS	PCSK1 PCSK2 PCSK4 PCSK6	4.02e-09	9	46	4	IPR022398
Domain	Peptidase_S8_Ser-AS	PCSK1 PCSK2 PCSK4 PCSK6	4.02e-09	9	46	4	IPR023828
Domain	Peptidase_S8_subtilisin-rel	PCSK1 PCSK2 PCSK4 PCSK6	6.69e-09	10	46	4	IPR015500
Domain	SUBTILASE_ASP	PCSK1 PCSK2 PCSK4 PCSK6	6.69e-09	10	46	4	PS00136
Domain	SUBTILASE_HIS	PCSK1 PCSK2 PCSK4 PCSK6	6.69e-09	10	46	4	PS00137
Domain	SUBTILASE_SER	PCSK1 PCSK2 PCSK4 PCSK6	6.69e-09	10	46	4	PS00138
Domain	-	PCSK1 PCSK2 PCSK4 PCSK6	1.05e-08	11	46	4	3.40.50.200
Domain	Peptidase_S8/S53_dom	PCSK1 PCSK2 PCSK4 PCSK6	1.05e-08	11	46	4	IPR000209
Domain	Peptidase_S8	PCSK1 PCSK2 PCSK4 PCSK6	1.05e-08	11	46	4	PF00082
Domain	Propept_inh	PCSK1 PCSK2 PCSK4 PCSK6	7.49e-08	17	46	4	IPR009020
Domain	Galactose-bd-like	MEP1B PCSK1 PCSK2 SUCO PCSK4 PCSK6	1.10e-07	94	46	6	IPR008979
Domain	-	PCSK1 PCSK2 SUCO PCSK4 PCSK6	9.60e-07	73	46	5	2.60.120.260
Domain	AFAP	AFAP1L2 AFAP1L1	1.78e-05	3	46	2	IPR030113
Domain	Furin_repeat	PCSK4 PCSK6	8.85e-04	18	46	2	IPR006212
Domain	FU	PCSK4 PCSK6	8.85e-04	18	46	2	SM00261
Domain	SH3_domain	CACNB3 DST BCAR1 MIA2	2.08e-03	220	46	4	IPR001452
Domain	Spectrin_repeat	MCF2 DST	2.31e-03	29	46	2	IPR002017
Domain	EGF	MEP1B FAT1 PCSK6 AREG	2.63e-03	235	46	4	SM00181
Domain	Spectrin/alpha-actinin	MCF2 DST	2.81e-03	32	46	2	IPR018159
Domain	SPEC	MCF2 DST	2.81e-03	32	46	2	SM00150
Domain	EGF-like_dom	MEP1B FAT1 PCSK6 AREG	3.24e-03	249	46	4	IPR000742
Domain	EGF	MEP1B FAT1 AREG	3.68e-03	126	46	3	PF00008
Domain	HEAT	CAND1 CLASP1	6.23e-03	48	46	2	PF02985
Domain	Growth_fac_rcpt_	FAT1 PCSK4 PCSK6	6.67e-03	156	46	3	IPR009030
Pathway	WP_GLP1_FROM_INTESTINE_AND_PANCREAS_AND_ROLE_IN_GLUCOSE_HOMEOSTASIS	PCSK1 PCSK2	1.05e-04	6	38	2	M48303
Pathway	REACTOME_RND1_GTPASE_CYCLE	ARHGAP5 DST FAM135A	1.93e-04	42	38	3	M41828
Pathway	REACTOME_RND1_GTPASE_CYCLE	ARHGAP5 DST FAM135A	2.07e-04	43	38	3	MM15679
Pubmed	The new enzymology of precursor processing endoproteases.	PCSK1 PCSK2 PCSK4 PCSK6	1.34e-11	5	46	4	1429684
Pubmed	Proteolytic processing in the secretory pathway.	PCSK1 PCSK2 PCSK4 PCSK6	9.34e-11	7	46	4	10409610
Pubmed	The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.	PCSK1 PCSK2 PCSK4 PCSK6	9.34e-11	7	46	4	7819324
Pubmed	Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases.	PCSK1 PCSK2 PCSK4 PCSK6	1.87e-10	8	46	4	9885250
Pubmed	The activation and physiological functions of the proprotein convertases.	PCSK1 PCSK2 PCSK4 PCSK6	3.36e-10	9	46	4	18343183
Pubmed	The prohormone theory and the proprotein convertases: it is all about serendipity.	PCSK1 PCSK2 PCSK4 PCSK6	3.36e-10	9	46	4	21805236
Pubmed	The proprotein convertases, 20 years later.	PCSK1 PCSK2 PCSK4 PCSK6	3.36e-10	9	46	4	21805237
Pubmed	The biology and therapeutic targeting of the proprotein convertases.	PCSK1 PCSK2 PCSK4 PCSK6	3.36e-10	9	46	4	22679642
Pubmed	The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions.	PCSK1 PCSK2 PCSK4 PCSK6	3.36e-10	9	46	4	23775089
Pubmed	Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.	PCSK1 PCSK2 PCSK4 PCSK6	5.59e-10	10	46	4	16163737
Pubmed	Subtilisin-like proprotein convertase expression, localization, and activity in the human retina and optic nerve head.	PCSK1 PCSK2 PCSK6	2.17e-09	3	46	3	19339735
Pubmed	Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides.	PCSK1 PCSK2 PCSK4	8.65e-09	4	46	3	10701998
Pubmed	Processing of prothyrotropin-releasing hormone by the family of prohormone convertases.	PCSK1 PCSK2 PCSK6	2.16e-08	5	46	3	9242664
Pubmed	Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines.	PCSK1 PCSK2 PCSK6	4.32e-08	6	46	3	8940009
Pubmed	Murine subtilisin-like proteinase SPC6 is expressed during embryonic implantation, somitogenesis, and skeletal formation.	PCSK1 PCSK2 PCSK6	4.32e-08	6	46	3	9291583
Pubmed	Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals.	PCSK1 PCSK2 PCSK6	1.21e-07	8	46	3	10037747
Pubmed	SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis.	PCSK1 PCSK4 PCSK6	1.81e-07	9	46	3	8698813
Pubmed	Regional localization of three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes.	PCSK1 TYR PCSK2	7.80e-07	14	46	3	1354647
Pubmed	Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst.	PCSK1 PCSK2 PCSK6	1.20e-06	16	46	3	20876279
Pubmed	The proprotein convertase PC2 is involved in the maturation of prosomatostatin to somatostatin-14 but not in the somatostatin deficit in Alzheimer's disease.	PCSK1 PCSK2	1.71e-06	2	46	2	14614908
Pubmed	Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases.	PCSK1 PCSK2	1.71e-06	2	46	2	16293189
Pubmed	Histone demethylase KDM4B accelerates the progression of glioblastoma via the epigenetic regulation of MYC stability.	MYC KDM4B	1.71e-06	2	46	2	38093312
Pubmed	Targeted high-resolution quadrupole-Orbitrap mass spectrometry analyses reveal a significant reduction of tachykinin and opioid neuropeptides level in PC1 and PC2 mutant mouse spinal cords.	PCSK1 PCSK2	1.71e-06	2	46	2	28476408
Pubmed	Developmental expression of the prohormone convertases PC1 and PC2 in mouse pancreatic islets.	PCSK1 PCSK2	1.71e-06	2	46	2	7925129
Pubmed	Tachykinins Processing is Significantly Impaired in PC1 and PC2 Mutant Mouse Spinal Cord S9 Fractions.	PCSK1 PCSK2	1.71e-06	2	46	2	26373413
Pubmed	Decreased hypothalamic prohormone convertase expression in huntington disease patients.	PCSK1 PCSK2	1.71e-06	2	46	2	24226266
Pubmed	Endocrinomic profile of neurointermediate lobe pituitary prohormone processing in PC1/3- and PC2-Null mice using SELDI-TOF mass spectrometry.	PCSK1 PCSK2	1.71e-06	2	46	2	15956344
Pubmed	Biosynthesis of proTRH-derived peptides in prohormone convertase 1 and 2 knockout mice.	PCSK1 PCSK2	1.71e-06	2	46	2	22421509
Pubmed	cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.	PCSK1 PCSK2	1.71e-06	2	46	2	2264933
Pubmed	Immunohistochemical expressions of prohormone convertase (PC)1/3 and PC2 in carcinoids of various organs.	PCSK1 PCSK2	1.71e-06	2	46	2	10530621
Pubmed	Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition.	MYC BCAR1	1.71e-06	2	46	2	34192548
Pubmed	Analysis of peptides in prohormone convertase 1/3 null mouse brain using quantitative peptidomics.	PCSK1 PCSK2	1.71e-06	2	46	2	20412386
Pubmed	Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.	PCSK1 PCSK2	1.71e-06	2	46	2	1988934
Pubmed	Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2.	PCSK1 PCSK2	1.71e-06	2	46	2	8397508
Pubmed	Revisiting Proinsulin Processing: Evidence That Human β-Cells Process Proinsulin With Prohormone Convertase (PC) 1/3 but Not PC2.	PCSK1 PCSK2	1.71e-06	2	46	2	32291281
Pubmed	Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2.	PCSK1 PCSK2	1.71e-06	2	46	2	2017186
Pubmed	A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing.	PCSK1 PCSK2	1.71e-06	2	46	2	33962048
Pubmed	Comparative tissue distribution of the processing enzymes "prohormone thiol protease," and prohormone convertases 1 and 2, in human PTHrP-producing cell lines and mammalian neuroendocrine tissues.	PCSK1 PCSK2	1.71e-06	2	46	2	11720250
Pubmed	Differences in pH optima and calcium requirements for maturation of the prohormone convertases PC2 and PC3 indicates different intracellular locations for these events.	PCSK1 PCSK2	1.71e-06	2	46	2	7836407
Pubmed	cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.	PCSK1 PCSK2	1.71e-06	2	46	2	2169760
Pubmed	The pre-B-cell receptor associated protein VpreB3 is a useful diagnostic marker for identifying c-MYC translocated lymphomas.	MYC VPREB3	1.71e-06	2	46	2	20823132
Pubmed	Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion.	PCSK1 PCSK2	5.13e-06	3	46	2	22396549
Pubmed	Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study.	PCSK1 PCSK2	5.13e-06	3	46	2	12358783
Pubmed	Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor.	PCSK1 PCSK2	5.13e-06	3	46	2	16476726
Pubmed	n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung-Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout.	FAT1 CMKLR1	5.13e-06	3	46	2	37686333
Pubmed	Differential processing of proenkephalin by prohormone convertases 1(3) and 2 and furin.	PCSK1 PCSK2	5.13e-06	3	46	2	8262946
Pubmed	Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1-11.2, and furin (mouse 7[D1-E2] region).	PCSK1 PCSK2	5.13e-06	3	46	2	1765368
Pubmed	Prohormone convertases 1/3 and 2 together orchestrate the site-specific cleavages of progastrin to release gastrin-34 and gastrin-17.	PCSK1 PCSK2	5.13e-06	3	46	2	18554181
Pubmed	Processing of mouse proglucagon by recombinant prohormone convertase 1 and immunopurified prohormone convertase 2 in vitro.	PCSK1 PCSK2	5.13e-06	3	46	2	7730317
Pubmed	PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism.	PCSK1 PCSK2	5.13e-06	3	46	2	17645548
Pubmed	On the tissue-specific processing of procholecystokinin in the brain and gut--a short review.	PCSK1 PCSK2	5.13e-06	3	46	2	15075450
Pubmed	The cell-specific pattern of cholecystokinin peptides in endocrine cells versus neurons is governed by the expression of prohormone convertases 1/3, 2, and 5/6.	PCSK1 PCSK2	5.13e-06	3	46	2	18096669
Pubmed	Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected].	PEAK1 BCAR1	5.13e-06	3	46	2	20534451
Pubmed	Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine.	PCSK1 PCSK2	5.13e-06	3	46	2	18706454
Pubmed	A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice.	PCSK1 PCSK2	5.13e-06	3	46	2	17698597
Pubmed	Biological processing of the cocaine and amphetamine-regulated transcript precursors by prohormone convertases, PC2 and PC1/3.	PCSK1 PCSK2	5.13e-06	3	46	2	12584191
Pubmed	An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing.	PCSK1 PCSK2	5.13e-06	3	46	2	3053705
Pubmed	Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide.	PCSK1 PCSK2	5.13e-06	3	46	2	14693708
Pubmed	On the processing of proghrelin to ghrelin.	PCSK1 PCSK2	1.03e-05	4	46	2	17050541
Pubmed	The proprotein convertases furin and PACE4 play a significant role in tumor progression.	PCSK2 PCSK6	1.03e-05	4	46	2	10900462
Pubmed	Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid.	PCSK1 PCSK2	1.03e-05	4	46	2	19628676
Pubmed	Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression.	PCSK1 PCSK2	1.71e-05	5	46	2	18410501
Pubmed	Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression.	PCSK1 PCSK2	1.71e-05	5	46	2	19837164
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	APBA2 DST BCAR1 KHDRBS3	1.97e-05	120	46	4	31413325
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	MYC APBA2 SRRT ZNF318 BCAR1 REV3L FAM135A CNN3	2.53e-05	922	46	8	27609421
Pubmed	Translation of insulin granule proteins are regulated by PDI and PABP.	PCSK1 PCSK2	2.56e-05	6	46	2	32248978
Pubmed	Mechanisms of reduced fertility in Hoxa-10 mutant mice: uterine homeosis and loss of maternal Hoxa-10 expression.	MYC AREG	2.56e-05	6	46	2	8787743
Pubmed	Phenotype of entero-endocrine L cells becomes restricted during development.	PCSK1 PCSK2	3.58e-05	7	46	2	23027401
Pubmed	Identification of two chromosomal loci determining glucose intolerance in a C57BL/6 mouse strain.	PCSK1 PCSK2	3.58e-05	7	46	2	10894496
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	APBA2 ARHGAP5 CAND1 DST REV3L MIA2 IFT88 ACO1 PCSK6	4.00e-05	1285	46	9	35914814
Pubmed	Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human.	PCSK4 PCSK6	4.77e-05	8	46	2	7782070
Pubmed	Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas.	PCSK1 PCSK2	4.77e-05	8	46	2	12049785
Pubmed	Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix.	MYC IBSP	6.12e-05	9	46	2	18458345
Pubmed	Craniofacial Ciliopathies Reveal Specific Requirements for GLI Proteins during Development of the Facial Midline.	MYC IFT88	6.12e-05	9	46	2	27802276
Pubmed	Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin.	PCSK1 PCSK2	6.12e-05	9	46	2	8389457
Pubmed	SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling.	MYC AREG	7.65e-05	10	46	2	27046831
Pubmed	Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation.	PCSK1 PCSK2	7.65e-05	10	46	2	16627579
Pubmed	trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues.	PCSK1 TYR	9.34e-05	11	46	2	8223273
Pubmed	The gene map of the Norway rat (Rattus norvegicus) and comparative mapping with mouse and man.	MYC TYR ACO1	9.35e-05	66	46	3	1889815
Pubmed	Knock-in of diphteria toxin A chain gene at Ins2 locus: effects on islet development and localization of Ins2 expression in the brain.	PCSK1 PCSK2	1.12e-04	12	46	2	15587270
Pubmed	ILDR2 stabilization is regulated by its interaction with GRP78.	ILDR2 ARHGAP5	1.12e-04	12	46	2	33863978
Pubmed	Abrogation of protein convertase 2 activity results in delayed islet cell differentiation and maturation, increased alpha-cell proliferation, and islet neogenesis.	PCSK1 PCSK2	1.12e-04	12	46	2	12933680
Pubmed	Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient mice.	TYR MIA2	1.32e-04	13	46	2	11839810
Pubmed	A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing.	PCSK1 TYR	1.54e-04	14	46	2	8114702
Pubmed	Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas.	PCSK1 PCSK2	1.78e-04	15	46	2	11076772
Pubmed	Integrin signalling regulates YAP and TAZ to control skin homeostasis.	MYC AREG	1.78e-04	15	46	2	26989177
Pubmed	Chromosomal locations of the mouse fatty acid oxidation genes Cpt1a, Cpt1b, Cpt2, Acadvl, and metabolically related Crat gene.	MYC CPT1B	2.30e-04	17	46	2	9680378
Pubmed	Functional identity of hypothalamic melanocortin neurons depends on Tbx3.	PCSK1 PCSK2	2.58e-04	18	46	2	32694784
Pubmed	Expression of Ins1 and Ins2 genes in mouse fetal liver.	PCSK1 PCSK2	2.58e-04	18	46	2	24258027
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	FAT1 ZNF318 AFAP1L2 TAF1L ZC3H6 AFAP1L1	2.82e-04	689	46	6	36543142
Pubmed	The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7.	MYC CAND1	2.88e-04	19	46	2	22405651
Pubmed	A major susceptibility locus to murine lung carcinogenesis maps on chromosome 6.	MYC TYR	2.88e-04	19	46	2	8499946
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	APBA2 ZNF318 PEAK1 FAM135A	4.06e-04	263	46	4	34702444
Pubmed	A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.	MYC TYR	4.64e-04	24	46	2	8626800
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	FAT1 ZNF318 CAND1 PEAK1 DST FAM135A	5.34e-04	777	46	6	35844135
Pubmed	Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes.	APBA2 PCSK6	5.45e-04	26	46	2	16280085
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	APBA2 PEAK1 DST FAM135A	5.50e-04	285	46	4	34369648
Pubmed	Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice.	SUCO IBSP	5.88e-04	27	46	2	20440000
Pubmed	BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion.	PCSK1 PCSK2	6.79e-04	29	46	2	17339028
Pubmed	Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure.	PCSK1 PCSK2	7.27e-04	30	46	2	22980982
Cytoband	9p21.1	TAF1L ACO1	2.90e-04	25	46	2	9p21.1
Cytoband	Ensembl 112 genes in cytogenetic band chr9p21	TAF1L ACO1	6.93e-03	124	46	2	chr9p21
Cytoband	Ensembl 112 genes in cytogenetic band chr1q24	ILDR2 SUCO	7.48e-03	129	46	2	chr1q24
GeneFamily	Proprotein convertase subtilisin/kexin family	PCSK1 PCSK2 PCSK4 PCSK6	8.85e-10	9	31	4	973
Coexpression	DAZARD_RESPONSE_TO_UV_NHEK_DN	MYC FAT1 ZNF318 DST REV3L CLASP1 SUCO NAA20	4.80e-08	300	46	8	M8702
Coexpression	DAZARD_UV_RESPONSE_CLUSTER_G6	FAT1 REV3L CLASP1 SUCO NAA20	5.52e-06	145	46	5	M1810
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#3_top-relative-expression-ranked_1000	SHPRH REV3L CLASP1 SUCO ZC3H6 FAM135A ZNF248	1.35e-05	369	46	7	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k3_1000
ToppCell	droplet-Lung-LUNG-1m-Epithelial-Club_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT1 AFAP1L2 KHDRBS3 PCSK4 AREG	1.37e-06	186	46	5	e52cf44989c57c433bf82e9fa13b4643e88f3577
ToppCell	droplet-Lung-LUNG-1m-Epithelial-club_cell_of_bronchiole\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT1 AFAP1L2 KHDRBS3 PCSK4 AREG	1.37e-06	186	46	5	4c0b59d845b79323e7a3287e7c4d249f5f322556
ToppCell	(2)_Fibroblasts-(21)_Fibro-2\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	PCSK2 ILDR2 SV2C PCSK6 AREG	1.56e-06	191	46	5	5ee353c79055c08e8a3e2b43a0345bceb09f3890
ToppCell	facs-Lung-3m-Endothelial-arterial_endothelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CMKLR1 AFAP1L2 DST FAM135A CNN3	1.56e-06	191	46	5	6e6b2cb390cc5cd0356924a2c36fbe5b5bd5966c
ToppCell	facs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CMKLR1 AFAP1L2 DST FAM135A CNN3	1.56e-06	191	46	5	482db995930346be69072ace2fd78fd453e97fb5
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ZNF318 PCSK4 VPREB3 AREG	1.74e-05	150	46	4	744050a1b665c6989f37141348af3df7579a73c9
ToppCell	AT1-AT2_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	ARHGAP5 PEAK1 KHDRBS3 PXDC1	2.77e-05	169	46	4	815474855a70498a74e52f6583113c63b7267a0c
ToppCell	(00)_Basal-(1)_24hpi\|(00)_Basal / shred by cell type and Timepoint	MYC AFAP1L2 PXDC1 AREG	3.04e-05	173	46	4	a8e62e7d8baf6af691acd5c50deedbadc119ceba
ToppCell	IPF-Lymphoid-ILC_A\|Lymphoid / Disease state, Lineage and Cell class	MEP1B ILDR2 CLASP1 AREG	3.18e-05	175	46	4	b6d1e40d9339426d778481fd67ab7cbc0f6cb5b2
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK2 VPREB3 CNN3 PXDC1	3.25e-05	176	46	4	c6484334187f64cd00cd35e77d8ae436556b4260
ToppCell	facs-Lung-18m-Hematologic-Lymphocytic_NK_ILC-Alox5+_lymphocyte-Alox5+_lymphocyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PCSK1 SV2C CPT1B AREG	3.32e-05	177	46	4	b7cfa3776f58377e35830780650d236b5cceecee
ToppCell	facs-Lung-18m-Hematologic-Lymphocytic_NK_ILC-Alox5+_lymphocyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PCSK1 SV2C CPT1B AREG	3.32e-05	177	46	4	1730e640986e50943bd781b7d949bcc5b7c12dde
ToppCell	ILEUM-inflamed-(9)_Enteric_neurons\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PCSK2 DST KHDRBS3 CNN3	3.39e-05	178	46	4	d9142151819afb0dc22bfb32a9c9dba5f553067d
ToppCell	ILEUM-inflamed-(9)_Neuro_cell\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PCSK2 DST KHDRBS3 CNN3	3.39e-05	178	46	4	611504b0a9e6318b18fba83787b03f9245c82252
ToppCell	droplet-Bladder-nan-24m-Epithelial-endothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APBA2 PCSK2 PXDC1 PCSK6	3.47e-05	179	46	4	3d6bb3cfe89d60f2f00aead9341f9967e5313763
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-B_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYC ZNF318 VPREB3 CNN3	3.62e-05	181	46	4	477c572c5c1efceee49732cc9e8b1dad68a7e6e5
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-B_cell-B_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYC ZNF318 VPREB3 CNN3	3.62e-05	181	46	4	909280b44085d8e96fcd3cbcba6bff94badd41e8
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP-neuro_pre_proliferating_SCP_(4)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PCSK2 AFAP1L2 KHDRBS3 PCSK6	3.70e-05	182	46	4	bfb725fff3d20066d8ac0a6ba2f88498fcbd876e
ToppCell	facs-Lung-nan-3m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CMKLR1 AFAP1L2 DST FAM135A	3.78e-05	183	46	4	12e876d6205af8aad74265c668b5e95b9e7487f3
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP-neuro_SCP_(0)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	PCSK2 AFAP1L2 KHDRBS3 PCSK6	3.78e-05	183	46	4	f517215ff45dec914af52dfdbc4579c19654c3aa
ToppCell	3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCSK2 AFAP1L2 DST CNN3	3.86e-05	184	46	4	226ccac00ac1c3a0ad7283785fd14312320e0ca6
ToppCell	droplet-Spleen-nan-24m-Lymphocytic-B_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYC VPREB3 CNN3 PXDC1	3.86e-05	184	46	4	a740ceffa62175578e6cff62da1f8dfaf40098e5
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CMKLR1 AFAP1L2 CLASP1 FAM135A	4.03e-05	186	46	4	c116cc9f41971622264434ebe29d18e719b0ae19
ToppCell	droplet-Spleen-nan-3m\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF318 VPREB3 CNN3 PXDC1	4.03e-05	186	46	4	26f1e9930adf2fe4af0819e56f69915bd8330e4a
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	APBA2 REV3L ACO1 PXDC1	4.03e-05	186	46	4	10565fce7e1b4ec88bc8e1ed6410a83800be5014
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP-neuro_proliferating_SCP1_(1)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PCSK2 AFAP1L2 KHDRBS3 PCSK6	4.03e-05	186	46	4	3113c85d0ac5fc46532c19b1bb71f34b985e1276
ToppCell	droplet-Spleen-nan-3m-Lymphocytic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF318 VPREB3 CNN3 PXDC1	4.11e-05	187	46	4	91c8e93bde0d1d1a4e324b0acf2afda00f4fb3bf
ToppCell	droplet-Spleen-nan-3m-Lymphocytic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF318 VPREB3 CNN3 PXDC1	4.11e-05	187	46	4	382db691eb0b3e089e816bed3d6699cc2d4e1bda
ToppCell	droplet-Spleen-nan-3m-Lymphocytic-B_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF318 VPREB3 CNN3 PXDC1	4.20e-05	188	46	4	8b1485e63cd4020ba5334a8d4b84725b164549bf
ToppCell	3'-GW_trimst-2-LargeIntestine-Neuronal\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCSK2 AFAP1L2 DST CNN3	4.20e-05	188	46	4	ccd2541892112a7a303f766adf9a7afeb754498c
ToppCell	5'-Adult-LymphNode-Hematopoietic-T_cells-NK_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	APBA2 ILDR2 CLASP1 AREG	4.29e-05	189	46	4	5a9c3c61998efc40a5d2042e0f568b52103734a9
ToppCell	normal_Lung-Endothelial_cells-Lymphatic_ECs\|normal_Lung / Location, Cell class and cell subclass	BCAR1 CNN3 PCSK6 AFAP1L1	4.38e-05	190	46	4	2185db6007404a2b22325f91460dd17635be9bba
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BCAR1 PXDC1 PCSK6 AFAP1L1	4.38e-05	190	46	4	6e6ce6dd549d1c38cfef5b3f8be06ab01ce344b7
ToppCell	(2)_Fibroblasts-(21)_Fibro-2\|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis	ILDR2 SV2C PCSK6 AREG	4.38e-05	190	46	4	d2afa08ad868acc6fce308ec21b0bf93591d4010
ToppCell	droplet-Spleen-nan-18m-Lymphocytic-B_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF318 VPREB3 CNN3 PXDC1	4.38e-05	190	46	4	ee7b60cdf93c695ea2d59a170ca8cf4dc93e7eb2
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	DST BCAR1 ACO1 NAA20	4.56e-05	192	46	4	e1deb743b1f39b58a46b8df134e79d512a000273
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK1 PCSK2 ARHGAP5 DST	4.56e-05	192	46	4	1304e69c92cef3bd8c82e3c035a7562f5440139a
ToppCell	3'-Distal_airway-Endothelial-Lymphatic_EC\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYC BCAR1 CNN3 AFAP1L1	4.56e-05	192	46	4	2ec132a1740e865e7cc0f82ffd4772d43f7ac086
ToppCell	3'-Distal_airway-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYC BCAR1 CNN3 AFAP1L1	4.56e-05	192	46	4	3792c53b5d4b759573e1c7bb89ef9b654c9cbfcd
ToppCell	3'-Distal_airway-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYC BCAR1 CNN3 AFAP1L1	4.56e-05	192	46	4	64022a47dccd7966777f6741d1c68e298f37ca9d
ToppCell	3'-Distal_airway-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature-Lymphatic_EC_mature_L.2.5.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYC BCAR1 CNN3 AFAP1L1	4.56e-05	192	46	4	f67a88bd039944d3d7a5a4a9f2e053985075155c
ToppCell	facs-Aorta-Heart-3m-Mesenchymal\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ILDR2 CACNB3 FAT1 PCSK6	4.56e-05	192	46	4	0dc1f46e40346ed0b286e53b106a812441575100
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	CACNB3 DST BCAR1 ACO1	4.65e-05	193	46	4	aa679fb27f914a931e51cff7153861cde0edfd85
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK1 PCSK2 ARHGAP5 DST	4.75e-05	194	46	4	92b39a935e8c577eb1123d706d168fa13cf3344c
ToppCell	COVID-19-Myeloid-TRAM2\|COVID-19 / Condition, Lineage and Cell class	DST BCAR1 ACO1 PXDC1	4.75e-05	194	46	4	c5bdf2b58c10dcb09797ddaf46b2e6c80d10399f
ToppCell	facs-Brain_Myeloid-Hippocampus\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP5 PEAK1 DST KHDRBS3	4.84e-05	195	46	4	a1478021a3ed0e779716393124ca2a7770c433b7
ToppCell	Tracheal-10x5prime-Stromal-Schwann\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PCSK2 ILDR2 SV2C AFAP1L2	4.94e-05	196	46	4	b6226163d9fc93ecfff2115bb74408303a000490
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	CACNB3 DST BCAR1 ACO1	4.94e-05	196	46	4	fe90501010128b72e6711c567cb04b012f1520a4
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCSK2 AFAP1L2 DST CNN3	4.94e-05	196	46	4	e6adcfe1a00d4910e0b92848f8a80224e0d6db12
ToppCell	Sepsis-ICU-SEP-Myeloid-cDC1\|ICU-SEP / Disease, condition lineage and cell class	ILDR2 ARHGAP5 ZNF318 DST	5.04e-05	197	46	4	e3174e90ea6136f1aa3a4a185b86458e35d51fd4
ToppCell	Tracheal-10x3prime_v2-Immune_Lymphocytic-NK-ILC-T_NK-ILC\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	APBA2 MCF2 AFAP1L2 AREG	5.04e-05	197	46	4	9791923feefbd78810242113ad2a08ce4c2bb4f2
ToppCell	(0)_NK_cell\|World / shred on Cell_type and subtype	APBA2 ILDR2 CLASP1 AREG	5.14e-05	198	46	4	dd8d5d635df7d4875c7a19f605e1289bc66bcfa6
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYC FAT1 DST KHDRBS3	5.14e-05	198	46	4	fc00cb25cdc6c31b7f9d397bc9f9a8f4e9708003
ToppCell	Bronchus_Control_(B.)-Endothelial-TX-Bronchial_vessel\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	PCSK1 PCSK2 FAT1 DST	5.14e-05	198	46	4	dcf334d13e5b0018fee24febccfef91c9e17843b
ToppCell	mLN-(0)_NK_cell-(00)_NK\|mLN / shred on region, Cell_type, and subtype	APBA2 ILDR2 CLASP1 AREG	5.24e-05	199	46	4	59d8e4f57580c7273308c32e5308fc1d704b1f6d
ToppCell	mLN-NK_cell-NK\|mLN / Region, Cell class and subclass	APBA2 ILDR2 CLASP1 AREG	5.24e-05	199	46	4	cc9836b8d18edabe8849a3e948b84d954ef68c48
ToppCell	mLN-NK_cell\|mLN / Region, Cell class and subclass	APBA2 ILDR2 CLASP1 AREG	5.24e-05	199	46	4	dcc1d9a3f6f0e64f111d18386bfe5b154e9d5bbe
ToppCell	Biopsy_Other_PF-Endothelial-Lymphatic_Endothelial_cells\|Biopsy_Other_PF / Sample group, Lineage and Cell type	BCAR1 CNN3 PCSK6 AFAP1L1	5.24e-05	199	46	4	aa80c77fe4f6a141c780c7d8ecfff5d5a1c3b845
ToppCell	mLN-(0)_NK_cell\|mLN / shred on region, Cell_type, and subtype	APBA2 ILDR2 CLASP1 AREG	5.24e-05	199	46	4	05f5ae4c049f242131a7f59bcce4b18ed52f11be
ToppCell	Tracheal-10x5prime-Stromal-Schwann-Schwann_Myelinating\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ILDR2 SV2C AFAP1L2 PCSK6	5.24e-05	199	46	4	2b567b6fd8addf059bbf2b72c55a7647aefdc595
ToppCell	(1)_T_cell-(16)_Tfh\|(1)_T_cell / shred on Cell_type and subtype	MYC APBA2 ARHGAP5 AREG	5.34e-05	200	46	4	3b28137e8e69b98fde9f6ab8320cb4d1c3543ef9
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Lymphatic-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	APBA2 CNN3 PCSK6 AFAP1L1	5.34e-05	200	46	4	f99d0d3f51b4893fa7898c5b435494358a654cbd
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Interneuron\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	AFAP1L2 CPT1B CDH9 PXDC1	5.34e-05	200	46	4	a6500d0d2e8bcac92381ab771dbdee66b0e1d48e
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Lymphatic\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	APBA2 CNN3 PCSK6 AFAP1L1	5.34e-05	200	46	4	e65d4ae3d48f68c12edd5dc2c2f4e25e4acfadf1
ToppCell	Parenchyma_Control_(B.)-Endothelial-TX-Lymphatic\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	APBA2 CNN3 PCSK6 AFAP1L1	5.34e-05	200	46	4	4ec8e30dd241d83a1bba1c5967b6a4656afbfafd
ToppCell	mild-NK_CD56bright\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PEAK1 DST CLASP1 AREG	5.34e-05	200	46	4	a195bc6784346f706d4cd5b740adac1d950ce88a
ToppCell	mild-NK_CD56bright\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PEAK1 DST CLASP1 AREG	5.34e-05	200	46	4	6de701985a0b92a7dece1b0e4a76e13756ccc0dd
ToppCell	(00)_NK\|World / shred on Cell_type and subtype	APBA2 ILDR2 CLASP1 AREG	5.55e-05	202	46	4	da1667a138a1195bd5fc9281495dd10e73066843
ToppCell	Severe-B_naive-13\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	ZNF318 IFT88 AREG	2.34e-04	116	46	3	f81a7c3e9cbf39124232d98e2a3a3e308137f391
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Tac2_Tacstd2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	FAT1 CDH9 PXDC1	2.52e-04	119	46	3	e868453c02dcf0e07821886b81ca739887d43c67
ToppCell	Severe-B_naive-13\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	ZNF318 IFT88 AREG	2.58e-04	120	46	3	d08edc09de8497714af55a6ca08a447cd71095e7
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Esm1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CDH9 PXDC1 PCSK6	2.65e-04	121	46	3	056d0f0f7a4d1b2d38b83647bbe4468b7c959ce6
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sncg-Sncg_Vip_Nptx2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CDH9 CNN3 AREG	2.71e-04	122	46	3	91e338db581b36baffecc323b1909f2069b27242
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Crh_4930553C11Rik_\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	FAT1 CDH9 PXDC1	3.19e-04	129	46	3	6bc85761dea1f97c19bb379a99e4daf85d53201e
ToppCell	facs-Pancreas-Exocrine-24m-Endothelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TYR MCF2 AREG	3.27e-04	130	46	3	8c81853c806e9a0d562e00dc5e00a8fc569a854c
ToppCell	facs-Pancreas-Exocrine-24m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TYR MCF2 AREG	3.27e-04	130	46	3	3041d20fe964d282d95c0312396f26bc93929056
ToppCell	facs-Pancreas-Exocrine-24m-Endothelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TYR MCF2 AREG	3.27e-04	130	46	3	3b6a8eaef593db73c2fad2260b9f1e15950ccb70
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Col15a1_Pde1a\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CDH9 IBSP AREG	3.57e-04	134	46	3	d63fff23040eada31bc35ba1e05b7c6a663e0037
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-innate_lymphocytic-immature_natural_killer_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DST AREG AFAP1L1	4.59e-04	146	46	3	40fac8a298152ec7f7eeeed5a2d28541aea3b338
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TYR SV2C PXDC1	4.68e-04	147	46	3	c8e5bdc3538089acd35a4b41390afaec0ac6d1aa
ToppCell	Influenza_Severe-CD4+_T_naive\|World / Disease group and Cell class	MYC APBA2 AREG	4.87e-04	149	46	3	ce6552063510aa3e0b9d6e5b531eea67410e7056
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PCSK2 MCF2 FOXN2	4.96e-04	150	46	3	8645b9c7f9511ed6cc9afe04440c2873a3094150
ToppCell	Children_(3_yrs)-Immune-dendritic_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MCF2 FOXN2 AREG	5.16e-04	152	46	3	0769857f25da2e6169420818e61d65e33b7277b1
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ILDR2 DST AREG	5.26e-04	153	46	3	91e9d70a5d3f6fd68c284ed0cc113f03d7d1e10b
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ILDR2 DST AREG	5.26e-04	153	46	3	f17f62646633cf95c810dcd5328978058741b276
ToppCell	COVID-19_Severe-CD8+_T_naive\|World / disease group, cell group and cell class	MYC APBA2 CNN3	5.36e-04	154	46	3	b568417d88a78d8c46688847f0f5f4989bd36387
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	PCSK4 VPREB3 AREG	5.36e-04	154	46	3	874b1220337276489a89fcc9a39bc81ba6b68baf
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_C\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ILDR2 PEAK1 AREG	5.56e-04	156	46	3	e6798d2b9c2c1fc6525c24f596f25aa85a375651
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PCSK1 PCSK2 SV2C	5.88e-04	159	46	3	7747cef94c55144fddcd024a7495318357f1351b
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TYR ILDR2 VPREB3	5.99e-04	160	46	3	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TYR ILDR2 VPREB3	5.99e-04	160	46	3	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	ICU-SEP-Myeloid-cDC1\|ICU-SEP / Disease, Lineage and Cell Type	ILDR2 ZNF318 DST	6.10e-04	161	46	3	9fb73909fc2ec99f96ca2eed1a053bce89de7d16
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	PCSK2 MCF2 KHDRBS3	6.32e-04	163	46	3	218b9ba099cb27aa91c6b73bf89b44895f5dddc3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PCSK1 PCSK2 MCF2	6.43e-04	164	46	3	43630a448f4369fa9e4e3eccdf3b9f29cec16c39
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PCSK1 PCSK2 MCF2	6.43e-04	164	46	3	108fbecb56d69a675d6ce6e826a873ae528f2fd7
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-2_VIP_PPAPDC1A\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TYR PXDC1 AREG	6.43e-04	164	46	3	e1032c406325873206c588ecdbee587d3e37e0ec
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PCSK1 PCSK2 MCF2	6.43e-04	164	46	3	46208f18325976c89f572f6627aea0582142b92d
ToppCell	facs-Aorta-Heart-24m-Endothelial-coronary_vascular_endothelial_cell\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCAR1 PXDC1 AFAP1L1	6.43e-04	164	46	3	5ee3729fab794d7acb172d14ec5d91aa1a61cd61
ToppCell	droplet-Fat-Scat-21m\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APBA2 AFAP1L2 AREG	6.55e-04	165	46	3	3f0c2486ea357d10dad0b703cf75cc29bdd5b5cf
ToppCell	severe-HSPC\|severe / disease stage, cell group and cell class	KHDRBS3 PCSK4 PXDC1	6.55e-04	165	46	3	acd837d88ad3786c263f74651a6c0e02fa2fa2c5
Computational	Genes upregulated in subsets of cells of a given type within various tumors	FAT1 PEAK1 DST	3.52e-04	50	30	3	GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_4
Computational	Genes upregulated in subsets of cells of a given type within various tumors	MYC DST AREG	3.52e-04	50	30	3	GAVISH_3CA_METAPROGRAM_EPITHELIAL_EMT_LIKE_1
Drug	B-13	PCSK1 PCSK2 BCAR1	7.31e-06	19	46	3	CID000070905
Drug	cardol	TYR IFT88	2.39e-05	4	46	2	CID000076617
Drug	dopamine quinone	PCSK1 PCSK2	3.98e-05	5	46	2	ctd:C104705
Drug	Isocorydine (+) [475-67-2]; Up 200; 11.8uM; MCF7; HT_HG-U133A	APBA2 SRRT PEAK1 PCSK6 KDM4B	4.40e-05	194	46	5	2780_UP
Drug	Etifenin [63245-28-3]; Up 200; 12.4uM; MCF7; HT_HG-U133A	MCF2 ZNF318 MIA2 PCSK6 KDM4B	4.40e-05	194	46	5	4117_UP
Drug	Mycophenolic acid [24280-93-1]; Down 200; 12.4uM; MCF7; HT_HG-U133A	MYC APBA2 CLASP1 PCSK6 KDM4B	4.74e-05	197	46	5	4137_DN
Drug	nifedipine; Down 200; 10uM; MCF7; HG-U133A	FOXN2 ZNF318 KHDRBS3 PCSK6 KDM4B	4.74e-05	197	46	5	335_DN
Drug	Amidopyrine [58-15-1]; Up 200; 17.2uM; MCF7; HT_HG-U133A	MEP1B SRRT IBSP PXDC1 PCSK6	4.97e-05	199	46	5	6818_UP
Drug	Cimetidine [51481-61-9]; Up 200; 15.8uM; HL60; HG-U133A	TYR ZNF318 CPT1B KDM4B ZNF248	4.97e-05	199	46	5	1964_UP
Drug	Methantheline bromide [53-46-3]; Up 200; 9.6uM; MCF7; HT_HG-U133A	SRRT SV2C KHDRBS3 CNN3 ZNF248	4.97e-05	199	46	5	3560_UP
Drug	monoacetone glucose	TYR ACO1	5.96e-05	6	46	2	CID000087704
Drug	4-hydroxy-N-desmethyltamoxifen	MYC AREG	5.96e-05	6	46	2	ctd:C055492
Drug	1-carboxysalsolinol	TYR BCAR1	5.96e-05	6	46	2	CID000100185
Disease	Glioblastoma Multiforme	MYC SRRT FAT1 TAF1L	2.74e-05	111	46	4	C1621958
Disease	Ductal Carcinoma	MYC BCAR1	1.30e-04	11	46	2	C1176475
Disease	Glioblastoma	MYC SRRT FAT1	2.58e-04	79	46	3	C0017636
Disease	Giant Cell Glioblastoma	MYC SRRT FAT1	3.09e-04	84	46	3	C0334588
Disease	urinary bladder cancer (is_marker_for)	MYC AREG KDM4B	6.28e-04	107	46	3	DOID:11054 (is_marker_for)
Disease	Head Neoplasms	FAT1 AREG	6.42e-04	24	46	2	C0018675
Disease	Upper Aerodigestive Tract Neoplasms	FAT1 AREG	6.42e-04	24	46	2	C0887900
Disease	Cancer of Head	FAT1 AREG	6.42e-04	24	46	2	C0751177
Disease	Cancer of Neck	FAT1 AREG	6.97e-04	25	46	2	C0746787
Disease	Neck Neoplasms	FAT1 AREG	6.97e-04	25	46	2	C0027533
Disease	Squamous cell carcinoma	MYC AFAP1L2 AREG	9.64e-04	124	46	3	C0007137
Disease	Head and Neck Neoplasms	FAT1 AREG	1.22e-03	33	46	2	C0018671
Disease	Malignant neoplasm of liver	MYC CPT1B IFT88	1.42e-03	142	46	3	C0345904
Disease	Liver neoplasms	MYC CPT1B IFT88	1.42e-03	142	46	3	C0023903
Disease	photoreceptor cell layer thickness measurement	TYR DST AFAP1L1	1.60e-03	148	46	3	EFO_0803370
Disease	breast cancer (is_implicated_in)	MYC AREG KDM4B	1.67e-03	150	46	3	DOID:1612 (is_implicated_in)
Disease	lung cancer (is_marker_for)	MYC KDM4B	1.70e-03	39	46	2	DOID:1324 (is_marker_for)
Disease	Adult Medulloblastoma	MYC KDM4B	2.06e-03	43	46	2	C0278876
Disease	Childhood Medulloblastoma	MYC KDM4B	2.06e-03	43	46	2	C0278510
Disease	Melanotic medulloblastoma	MYC KDM4B	2.06e-03	43	46	2	C1275668
Disease	Medullomyoblastoma	MYC KDM4B	2.06e-03	43	46	2	C0205833
Disease	Desmoplastic Medulloblastoma	MYC KDM4B	2.06e-03	43	46	2	C0751291
Disease	Malignant Head and Neck Neoplasm	FAT1 AREG	2.16e-03	44	46	2	C0278996
Disease	response to beta blocker	TYR BCAR1	2.26e-03	45	46	2	EFO_0007766
Disease	Medulloblastoma	MYC KDM4B	2.78e-03	50	46	2	C0025149
Disease	hearing loss	TYR ZNF318	4.93e-03	67	46	2	EFO_0004238
Disease	TNF-related apoptosis-inducing ligand measurement	MEP1B PCSK6	5.67e-03	72	46	2	EFO_0008300

Protein segments in the cluster

Peptide	Gene	Start	Entry
DQDGYYYPDSLVGTD	ACO1	191	P21399
SSGADYDYSEEYDNE	AREG	76	P15514
EEDYADAYQDLYQPH	CACNB3	426	P54284
GYVYEAAQPEQDEYD	BCAR1	221	P56945
DYLGLDDFSSPYQDE	CREBRF	116	Q8IUR6
EGYYEEAEPYDTSLN	AFAP1L2	121	Q8N4X5
EGYQDYYPEEANGNT	APBA2	191	Q99767
DTDYYPGGYDIESDF	FAT1	4421	Q14517
ESYGDYIYDSNDQDD	DST	2581	Q03001
TYDPNYNYDDEDEDE	CAND1	306	Q86VP6
QNGYYEETDYSALDG	FAM135A	1096	Q9P2D6
EYYSASNGEPDEDAY	NAA20	136	P61599
NYDPLASYDFNDYDP	PCSK4	171	Q6UW60
SYASYDVNGNDYDPS	PCSK6	221	P29122
AVDYDDSYDEILNGY	PEAK1	306	Q9H792
NFDDGSYSDNLYPES	KDM4B	951	O94953
TDEDDLYSGYNDYNP	IFT88	11	Q13099
SSNYFYPTYDENEEE	MCF2	896	P10911
DYEDDPLGDSGYASQ	FOXN2	356	P32314
PTQETYGEYDYDDGY	KHDRBS3	261	O75525
GTAYDEQSYDSYDNS	KHDRBS3	276	O75525
PYDSLATYAYEGNDS	CDH9	731	Q9ULB4
YSDDISDSLNVPYDY	MEP1B	191	Q16820
YSYDPEDEASLSLYG	CPT1B	426	Q92523
SELNGDYGENIYPYE	MIA2	131	Q96PC5
DGDDPAAYVTNLSYY	PXDC1	206	Q5TGL8
YSRFQDEEDDDDYYP	SV2C	46	Q496J9
DDYYPAGETYNGEAN	SV2C	56	Q496J9
QPLYHSDYDEDDYDA	TAF1L	131	Q8IZX4
YDSVQPYFYCDEEEN	MYC	16	P01106
LPSDTSDDDDDPYYY	SHPRH	551	Q149N8
YDNGYEIYESENGEP	IBSP	271	P21815
DCFPYNNYPDSDDDT	ARHGAP5	971	Q13017
SLDYYNTCEYPNEDE	SRRT	621	Q9BXP5
DGYYEDADSSYPATR	AFAP1L1	156	Q8TED9
EDYNTSISYGDEYPD	CMKLR1	6	Q99788
YEPYGMYSDDDANSD	CLASP1	816	Q7Z460
SDSDYQAEYPDEYHG	CNN3	296	Q15417
EYDEYSTYSDDNFGN	ZC3H6	136	P61129
DEDDDDNYYISYSSP	REV3L	2106	O60673
SGFYQDDSLEEYYGQ	ILDR2	466	Q71H61
GYDYSYLQDSDPDSF	TYR	446	P14679
ELFDEDYDYPLDYNT	SUCO	471	Q9UBS9
DYDYPLDYNTGEDKS	SUCO	476	Q9UBS9
QPEDDADYYCSVGYG	VPREB3	106	Q9UKI3
LDQPTAAYEYYDAGN	ZNF318	1051	Q5VUA4
PYEYNEYGEIFCDNS	ZNF248	296	Q8NDW4
DIYANYDPEASYDFN	PCSK1	176	P29120
YNAEASYDFSSNDPY	PCSK2	181	P16519