Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	linoleoyl-CoA desaturase activity	FADS1 FADS2	9.18e-06	2	61	2	GO:0016213
GeneOntologyMolecularFunction	acyl-CoA desaturase activity	FADS1 FADS2	9.13e-05	5	61	2	GO:0016215
HumanPheno	Increased total bilirubin	LIPT1 MYO5B PRF1	2.14e-05	14	21	3	HP:0003573
Domain	CYTOCHROME_B5_2	FADS1 FA2H FADS2	8.37e-06	13	59	3	PS50255
Domain	CYTOCHROME_B5_1	FADS1 FA2H FADS2	8.37e-06	13	59	3	PS00191
Domain	Cyt-b5	FADS1 FA2H FADS2	1.06e-05	14	59	3	PF00173
Domain	Cyt_B5-like_heme/steroid-bd	FADS1 FA2H FADS2	1.06e-05	14	59	3	IPR001199
Domain	Cyt-b5	FADS1 FA2H FADS2	1.06e-05	14	59	3	SM01117
Domain	-	FADS1 FA2H FADS2	1.06e-05	14	59	3	3.10.120.10
Domain	Fatty_acid_desaturase	FADS1 FADS2	2.94e-05	3	59	2	IPR012171
Domain	Serpin_dom	SERPINA11 SERPINI2 SERPINB2	1.99e-04	36	59	3	IPR023796
Domain	SERPIN	SERPINA11 SERPINI2 SERPINB2	2.16e-04	37	59	3	SM00093
Domain	SERPIN	SERPINA11 SERPINI2 SERPINB2	2.16e-04	37	59	3	PS00284
Domain	Serpin	SERPINA11 SERPINI2 SERPINB2	2.33e-04	38	59	3	PF00079
Domain	Serpin_fam	SERPINA11 SERPINI2 SERPINB2	2.52e-04	39	59	3	IPR000215
Domain	FA_desaturase_dom	FADS1 FADS2	2.71e-04	8	59	2	IPR005804
Domain	FA_desaturase	FADS1 FADS2	2.71e-04	8	59	2	PF00487
Domain	DOCK_C	DOCK3 DOCK11	5.30e-04	11	59	2	IPR010703
Domain	DHR-1_domain	DOCK3 DOCK11	5.30e-04	11	59	2	IPR027007
Domain	DHR_2	DOCK3 DOCK11	5.30e-04	11	59	2	PS51651
Domain	DHR_1	DOCK3 DOCK11	5.30e-04	11	59	2	PS51650
Domain	DOCK-C2	DOCK3 DOCK11	5.30e-04	11	59	2	PF14429
Domain	DHR-2	DOCK3 DOCK11	5.30e-04	11	59	2	IPR027357
Domain	DHR-2	DOCK3 DOCK11	5.30e-04	11	59	2	PF06920
Domain	DOCK	DOCK3 DOCK11	5.30e-04	11	59	2	IPR026791
Domain	Metal_Hydrolase	AMDHD2 ADA2	2.59e-03	24	59	2	IPR032466
Domain	ARM-type_fold	DOCK3 RELCH SF3B1 DOCK11 ARFGEF2	4.30e-03	339	59	5	IPR016024
Domain	Serpin_CS	SERPINI2 SERPINB2	4.58e-03	32	59	2	IPR023795
Pathway	WP_SEBALEIC_ACID_FORMATION_AND_METABOLISM	FADS1 FADS2	1.22e-04	5	50	2	M48057
Pathway	WP_METABOLISM_OF_ALPHALINOLENIC_ACID	FADS1 FADS2	1.83e-04	6	50	2	M39844
Pathway	WP_LINOLEIC_ACID_METABOLISM_AFFECTED_BY_SARSCOV2	FADS1 FADS2	1.83e-04	6	50	2	M42575
Pathway	REACTOME_LINOLEIC_ACID_LA_METABOLISM	FADS1 FADS2	3.41e-04	8	50	2	MM14822
Pathway	REACTOME_LINOLEIC_ACID_LA_METABOLISM	FADS1 FADS2	3.41e-04	8	50	2	M27115
Pubmed	FADS1-FADS2 genetic polymorphisms are associated with fatty acid metabolism through changes in DNA methylation and gene expression.	FADS1 FADS2	3.03e-06	2	61	2	30157936
Pubmed	Impact of FADS genotype on polyunsaturated fatty acid content in human milk extracellular vesicles: A genetic association study.	FADS1 FADS2	3.03e-06	2	61	2	38566550
Pubmed	A novel FADS1 isoform potentiates FADS2-mediated production of eicosanoid precursor fatty acids.	FADS1 FADS2	3.03e-06	2	61	2	22619218
Pubmed	Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids.	FADS1 FADS2	3.03e-06	2	61	2	16670158
Pubmed	Limited Evidence for Selection at the FADS Locus in Native American Populations.	FADS1 FADS2	3.03e-06	2	61	2	32145021
Pubmed	Dietary n-3 and n-6 polyunsaturated fatty acids, the FADS gene, and the risk of gastric cancer in a Korean population.	FADS1 FADS2	3.03e-06	2	61	2	29491470
Pubmed	FADS1 FADS2 gene cluster, PUFA intake and blood lipids in children: results from the GINIplus and LISAplus studies.	FADS1 FADS2	3.03e-06	2	61	2	22629455
Pubmed	A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive differences in lifestyle.	FADS1 FADS2	3.03e-06	2	61	2	20364269
Pubmed	Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease.	FADS1 FADS2	3.03e-06	2	61	2	27004414
Pubmed	FADS Polymorphism, Omega-3 Fatty Acids and Diabetes Risk: A Systematic Review.	FADS1 FADS2	3.03e-06	2	61	2	29899246
Pubmed	Dietary pattern regulates fatty acid desaturase 1 gene expression in Indian pregnant women to spare overall long chain polyunsaturated fatty acids levels.	FADS1 FADS2	3.03e-06	2	61	2	30511301
Pubmed	Genetic variants of the FADS1 FADS2 gene cluster as related to essential fatty acid metabolism.	FADS1 FADS2	3.03e-06	2	61	2	19809313
Pubmed	Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life.	FADS1 FADS2	3.03e-06	2	61	2	20948998
Pubmed	Relationship between a common variant in the fatty acid desaturase (FADS) cluster and eicosanoid generation in humans.	FADS1 FADS2	3.03e-06	2	61	2	24962583
Pubmed	Maternal polymorphisms in the FADS1 and FADS2 genes modify the association between PUFA ingestion and plasma concentrations of omega-3 polyunsaturated fatty acids.	FADS1 FADS2	3.03e-06	2	61	2	31568926
Pubmed	Do FADS genotypes enhance our knowledge about fatty acid related phenotypes?	FADS1 FADS2	3.03e-06	2	61	2	19948371
Pubmed	The role of fatty acid desaturase (FADS) genes in oleic acid metabolism: FADS1 Δ7 desaturates 11-20:1 to 7,11-20:2.	FADS1 FADS2	3.03e-06	2	61	2	29413358
Pubmed	Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis.	FADS1 FADS2	3.03e-06	2	61	2	32186652
Pubmed	Insertion-deletions in a FADS2 intron 1 conserved regulatory locus control expression of fatty acid desaturases 1 and 2 and modulate response to simvastatin.	FADS1 FADS2	3.03e-06	2	61	2	22748975
Pubmed	Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition.	FADS1 FADS2	3.03e-06	2	61	2	23221573
Pubmed	Long-chain polyunsaturated fatty acid status in obesity: a systematic review and meta-analysis.	FADS1 FADS2	3.03e-06	2	61	2	25828602
Pubmed	FADS gene variants modulate the effect of dietary fatty acid intake on allergic diseases in children.	FADS1 FADS2	3.03e-06	2	61	2	21793953
Pubmed	Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplement.	FADS1 FADS2	3.03e-06	2	61	2	23160180
Pubmed	Genetic variation in FADS genes is associated with maternal long-chain PUFA status but not with cognitive development of infants in a high fish-eating observational study.	FADS1 FADS2	3.03e-06	2	61	2	26474818
Pubmed	Genetic variation of the FADS1 FADS2 gene cluster and n-6 PUFA composition in erythrocyte membranes in the European Prospective Investigation into Cancer and Nutrition-Potsdam study.	FADS1 FADS2	3.03e-06	2	61	2	20691134
Pubmed	Erythrocyte membrane phospholipid fatty acids, desaturase activity, and dietary fatty acids in relation to risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study.	FADS1 FADS2	3.03e-06	2	61	2	20980488
Pubmed	Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome.	FADS1 FADS2	3.03e-06	2	61	2	21733300
Pubmed	FADS2 polymorphisms are associated with plasma arachidonic acid and estimated desaturase-5 activity in a cross-sectional study.	FADS1 FADS2	3.03e-06	2	61	2	33011673
Pubmed	Increasing dietary EPA and DHA influence estimated fatty acid desaturase activity in systemic organs which is reflected in the red blood cell in mice.	FADS1 FADS2	3.03e-06	2	61	2	28697636
Pubmed	Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study.	FADS1 FADS2	3.03e-06	2	61	2	20484448
Pubmed	Decreased liver fatty acid delta-6 and delta-5 desaturase activity in obese patients.	FADS1 FADS2	3.03e-06	2	61	2	19875987
Pubmed	FADS1 and FADS2 polymorphism are associated with changes in fatty acid concentrations after calorie-restricted Central European and Mediterranean diets.	FADS1 FADS2	3.03e-06	2	61	2	31567872
Pubmed	Carrying minor allele of FADS1 and haplotype of FADS1 and FADS2 increased the risk of metabolic syndrome and moderate but not low fat diets lowered the risk in two Korean cohorts.	FADS1 FADS2	3.03e-06	2	61	2	29779171
Pubmed	Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children.	FADS1 FADS2	3.03e-06	2	61	2	21106917
Pubmed	Evidence for an association between genetic variants of the fatty acid desaturase 1 fatty acid desaturase 2 ( FADS1 FADS2) gene cluster and the fatty acid composition of erythrocyte membranes.	FADS1 FADS2	3.03e-06	2	61	2	18479586
Pubmed	Adiposity Associated Plasma Linoleic Acid is Related to Demographic, Metabolic Health and Haplotypes of FADS1/2 Genes in Irish Adults.	FADS1 FADS2	3.03e-06	2	61	2	29388724
Pubmed	FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer.	FADS1 FADS2	3.03e-06	2	61	2	38926633
Pubmed	Differences in erythrocyte phospholipid membrane long-chain polyunsaturated fatty acids and the prevalence of fatty acid desaturase genotype among African Americans and European Americans.	FADS1 FADS2	3.03e-06	2	61	2	33310680
Pubmed	Mendelian randomization shows sex-specific associations between long-chain PUFA-related genotypes and cognitive performance in Danish schoolchildren.	FADS1 FADS2	3.03e-06	2	61	2	28515069
Pubmed	Erythrocyte polyunsaturated fatty acid composition is associated with depression and FADS genotype in Caucasians.	FADS1 FADS2	3.03e-06	2	61	2	28552045
Pubmed	Association of fatty acid desaturase genes with attention-deficit/hyperactivity disorder.	FADS1 FADS2	3.03e-06	2	61	2	16893529
Pubmed	Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation.	FADS1 FADS2	3.03e-06	2	61	2	18936223
Pubmed	Docosahexaenoic acid (DHA) supplementation in pregnancy differentially modulates arachidonic acid and DHA status across FADS genotypes in pregnancy.	FADS1 FADS2	3.03e-06	2	61	2	25500337
Pubmed	FADS Gene Polymorphisms, Fatty Acid Desaturase Activities, and HDL-C in Type 2 Diabetes.	FADS1 FADS2	3.03e-06	2	61	2	28555039
Pubmed	Influence of FADS polymorphisms on tracking of serum glycerophospholipid fatty acid concentrations and percentage composition in children.	FADS1 FADS2	3.03e-06	2	61	2	21818279
Pubmed	Vitamin B-6 restriction impairs fatty acid synthesis in cultured human hepatoma (HepG2) cells.	FADS1 FADS2	3.03e-06	2	61	2	23211517
Pubmed	Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios.	FADS1 FADS2	3.03e-06	2	61	2	20427696
Pubmed	Uncovering the DNA methylation landscape in key regulatory regions within the FADS cluster.	FADS1 FADS2	3.03e-06	2	61	2	28957329
Pubmed	Associations of umbilical cord fatty acid profiles and desaturase enzyme indices with birth weight for gestational age in Japanese infants.	FADS1 FADS2	3.03e-06	2	61	2	33387849
Pubmed	FADS gene cluster polymorphisms: important modulators of fatty acid levels and their impact on atopic diseases.	FADS1 FADS2	3.03e-06	2	61	2	19776639
Pubmed	Polyunsaturated fatty acid regulation of adipocyte FADS1 and FADS2 expression and function.	FADS1 FADS2	3.03e-06	2	61	2	25755223
Pubmed	The role of FADS1/2 polymorphisms on cardiometabolic markers and fatty acid profiles in young adults consuming fish oil supplements.	FADS1 FADS2	3.03e-06	2	61	2	24936800
Pubmed	Early nutrition in combination with polymorphisms in fatty acid desaturase gene cluster modulate fatty acid composition of cheek cells' glycerophospholipids in school-age children.	FADS1 FADS2	3.03e-06	2	61	2	31638497
Pubmed	Interaction of fatty acid genotype and diet on changes in colonic fatty acids in a Mediterranean diet intervention study.	FADS1 FADS2	3.03e-06	2	61	2	24022589
Pubmed	FADS1-FADS2 gene cluster confers risk to polycystic ovary syndrome.	FADS1 FADS2	3.03e-06	2	61	2	26879377
Pubmed	Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.	FADS1 FADS2	3.03e-06	2	61	2	36864135
Pubmed	Lack of association of SNPs from the FADS1-FADS2 gene cluster with major depression or suicidal behavior.	FADS1 FADS2	3.03e-06	2	61	2	26513616
Pubmed	FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk.	FADS1 FADS2	3.03e-06	2	61	2	20335541
Pubmed	Association of two polymorphisms in the FADS1/FADS2 gene cluster and the risk of coronary artery disease and ischemic stroke.	FADS1 FADS2	3.03e-06	2	61	2	26261632
Pubmed	Delta-5 and delta-6 desaturases: crucial enzymes in polyunsaturated fatty acid-related pathways with pleiotropic influences in health and disease.	FADS1 FADS2	3.03e-06	2	61	2	25038994
Pubmed	FADS1 and FADS2 Gene Polymorphisms Modulate the Relationship of Omega-3 and Omega-6 Fatty Acid Plasma Concentrations in Gestational Weight Gain: A NISAMI Cohort Study.	FADS1 FADS2	3.03e-06	2	61	2	35268031
Pubmed	Genetically determined variation in polyunsaturated fatty acid metabolism may result in different dietary requirements.	FADS1 FADS2	3.03e-06	2	61	2	18626191
Pubmed	Role of FADS1 and FADS2 polymorphisms in polyunsaturated fatty acid metabolism.	FADS1 FADS2	3.03e-06	2	61	2	20045144
Pubmed	Polymorphisms in FADS1 and FADS2 alter desaturase activity in young Caucasian and Asian adults.	FADS1 FADS2	3.03e-06	2	61	2	21414826
Pubmed	FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease.	FADS1 FADS2	3.03e-06	2	61	2	18842780
Pubmed	Associations between Fatty Acid Intake and Status, Desaturase Activities, and FADS Gene Polymorphism in Centrally Obese Postmenopausal Polish Women.	FADS1 FADS2	3.03e-06	2	61	2	30103441
Pubmed	Compensatory induction of Fads1 gene expression in heterozygous Fads2-null mice and by diet with a high n-6/n-3 PUFA ratio.	FADS1 FADS2	3.03e-06	2	61	2	27613800
Pubmed	High Frequency of Ancestral Haplotype A of Fatty Acid Desaturase Genes in the Yakut Population.	FADS1 FADS2	3.03e-06	2	61	2	38860387
Pubmed	Reduction of Arachidonate Is Associated With Increase in B-Cell Activation Marker in Infants: A Randomized Trial.	FADS1 FADS2	3.03e-06	2	61	2	27276431
Pubmed	SNPs of the FADS gene cluster are associated with polyunsaturated fatty acids in a cohort of patients with cardiovascular disease.	FADS1 FADS2	3.03e-06	2	61	2	18320251
Pubmed	Polymorphisms of rs174616 in the FADS1-FADS2 gene cluster is associated with a reduced risk of type 2 diabetes mellitus in northern Han Chinese people.	FADS1 FADS2	3.03e-06	2	61	2	25981324
Pubmed	Brain tissue- and cell type-specific eQTL Mendelian randomization reveals efficacy of FADS1 and FADS2 on cognitive function.	FADS1 FADS2	3.03e-06	2	61	2	38316767
Pubmed	GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice.	FADS1 FADS2	3.03e-06	2	61	2	36806390
Pubmed	A case-control study between the gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and coronary artery disease in a Chinese Han population.	FADS1 FADS2	9.07e-06	3	61	2	21917437
Pubmed	Genetic variation in lipid desaturases and its impact on the development of human disease.	FADS1 FADS2	9.07e-06	3	61	2	20565855
Pubmed	A case-control study between gene polymorphisms of polyunsaturated fatty acid metabolic rate-limiting enzymes and acute coronary syndrome in Chinese Han population.	FADS1 FADS2	9.07e-06	3	61	2	23555103
Pubmed	Variation in the FADS1/2 gene cluster alters plasma n-6 PUFA and is weakly associated with hsCRP levels in healthy young adults.	FADS1 FADS2	9.07e-06	3	61	2	23867726
Pubmed	Identification of genes and pathways involved in the synthesis of Mead acid (20:3n-9), an indicator of essential fatty acid deficiency.	FADS1 FADS2	9.07e-06	3	61	2	24184513
Pubmed	Regulation of desaturase expression in HL60 cells.	FADS1 FADS2	9.07e-06	3	61	2	17852835
Pubmed	Association of fatty acid desaturase gene polymorphisms with blood lipid essential fatty acids and perinatal depression among Canadian women: a pilot study.	FADS1 FADS2	9.07e-06	3	61	2	20395685
Pubmed	cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family.	FADS1 FADS2	9.07e-06	3	61	2	10860662
Pubmed	Fatty acid profile and estimated desaturase activities in whole blood are associated with metabolic health.	FADS1 FADS2	9.07e-06	3	61	2	32438926
Pubmed	Placental expression of Fatty Acid Desaturases 1, 2 and 3 in selected pregnancy pathologies.	FADS1 FADS2	9.07e-06	3	61	2	36652541
Pubmed	Association of polyunsaturated fatty acids in breast milk with fatty acid desaturase gene polymorphisms among Chinese lactating mothers.	FADS1 FADS2	9.07e-06	3	61	2	27269715
Pubmed	Clinical impact of small subclones harboring NOTCH1, SF3B1 or BIRC3 mutations in chronic lymphocytic leukemia.	SF3B1 BIRC3	9.07e-06	3	61	2	26819056
Pubmed	[A case-control study between gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and paranoid schizophrenia of Han ethnicity in Jilin Province].	FADS1 FADS2	9.07e-06	3	61	2	21560298
Pubmed	Fatty acid desaturase activity in mature red blood cells and implications for blood storage quality.	FADS1 FADS2	9.07e-06	3	61	2	33904180
Pubmed	Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2.	SF3B1 BIRC3	9.07e-06	3	61	2	23558524
Pubmed	Bivariate genome-wide association study suggests fatty acid desaturase genes and cadherin DCHS2 for variation of both compressive strength index and appendicular lean mass in males.	FADS1 FADS2	9.07e-06	3	61	2	22960237
Pubmed	Gene expression of desaturase (FADS1 and FADS2) and Elongase (ELOVL5) enzymes in peripheral blood: association with polyunsaturated fatty acid levels and atopic eczema in 4-year-old children.	FADS1 FADS2	9.07e-06	3	61	2	24167612
Pubmed	Umbilical cord PUFA are determined by maternal and child fatty acid desaturase (FADS) genetic variants in the Avon Longitudinal Study of Parents and Children (ALSPAC).	FADS1 FADS2	9.07e-06	3	61	2	22877655
Pubmed	Flavonoids as putative modulators of Δ4-, Δ5-, and Δ6-desaturases: Studies in cultured hepatocytes, myocytes, and adipocytes.	FADS1 FADS2	9.07e-06	3	61	2	30365230
Pubmed	FADS gene polymorphisms in Koreans: association with ω6 polyunsaturated fatty acids in serum phospholipids, lipid peroxides, and coronary artery disease.	FADS1 FADS2	9.07e-06	3	61	2	21040914
Pubmed	Genetic variants in desaturase gene, erythrocyte fatty acids, and risk for type 2 diabetes in Chinese Hans.	FADS1 FADS2	9.07e-06	3	61	2	24985009
Pubmed	Association Between Genetic Variants in FADS1-FADS2 and ELOVL2 and Obesity, Lipid Traits, and Fatty Acids in Tunisian Population.	FADS1 FADS2	9.07e-06	3	61	2	32584610
Pubmed	Increased Δ5- and Δ6-desaturase, cyclooxygenase-2, and lipoxygenase-5 expression and activity are associated with fatty acid and eicosanoid changes in cystic fibrosis.	FADS1 FADS2	1.81e-05	4	61	2	21605700
Pubmed	Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study.	FADS1 FADS2	1.81e-05	4	61	2	19148276
Pubmed	FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population.	FADS1 FADS2	1.81e-05	4	61	2	20562440
Pubmed	A gene map of the Best's vitelliform macular dystrophy region in chromosome 11q12-q13.1.	FADS1 FADS2	1.81e-05	4	61	2	9445487
Pubmed	Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia.	SF3B1 BIRC3	1.81e-05	4	61	2	23243274
Cytoband	Ensembl 112 genes in cytogenetic band chr18q21	RELCH MYO5B VPS4B SERPINB2	1.65e-04	205	61	4	chr18q21
Cytoband	18q21.33	RELCH VPS4B	2.06e-04	16	61	2	18q21.33
GeneFamily	Serpin peptidase inhibitors	SERPINA11 SERPINI2 SERPINB2	9.86e-05	37	44	3	739
GeneFamily	Fatty acid desaturases	FADS1 FADS2	1.61e-04	8	44	2	553
Drug	Chenodiol [474-25-9]; Up 200; 10.2uM; PC3; HT_HG-U133A	HIPK3 ACOT11 AMDHD2 SERPINB2 BIRC3 PLCH1	1.41e-05	196	61	6	7310_UP
Drug	Rapamycin; Up 200; 0.1uM; HL60; HT_HG-U133A	RTEL1 BIRC3 TNKS FUT1 PLCH1 SLC4A5	1.45e-05	197	61	6	6180_UP
Drug	Bucladesine sodium salt [16980-89-5]; Down 200; 7.8uM; PC3; HT_HG-U133A	MRPL57 ZNF592 PRF1 AMDHD2 SERPINB2 FUT1	1.45e-05	197	61	6	5886_DN
Disease	1-stearoyl-2-linoleoyl-GPI (18:0/18:2) measurement	FADS1 MYO5B FADS2	2.14e-06	13	59	3	EFO_0800413
Disease	Palmitoyl-arachidonoyl-glycerol (16:0/20:4) [2] measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0022103
Disease	Sphingomyelin (d18:2/14:0, d18:1/14:1) measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0022114
Disease	phosphatidylcholine acyl-alkyl C38:5 measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0801299
Disease	phosphatidylcholine acyl-alkyl C36:4 measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0801292
Disease	phosphatidylcholine acyl-alkyl C36:2 measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0801290
Disease	phosphatidylcholine diacyl C38:5 measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0801267
Disease	phosphatidylcholine diacyl C38:4 measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0801266
Disease	phosphatidylcholine diacyl C36:4 measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0801260
Disease	phosphatidylcholine diacyl C40:6 measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0801274
Disease	2-arachidonoylglycerol (20:4) measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0800182
Disease	phosphatidylcholine diacyl C36:3 measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0801259
Disease	phosphatidylcholine diacyl C34:4 measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0801255
Disease	2-linoleoyl-GPC (18:2) measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0800239
Disease	level of Phosphatidylcholine (O-16:0_22:5) in blood serum	FADS1 FADS2	2.35e-05	4	59	2	OBA_2045117
Disease	1-dihomo-linoleoyl-GPC (20:2) measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0800236
Disease	sphingomyeline C16:1 measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0801318
Disease	docosapentaenoate (n6 DPA; 22:5n6) measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0800249
Disease	1-linoleoyl-2-linolenoyl-GPC (18:2/18:3) measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0800483
Disease	eicosapentaenoylcholine measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0800482
Disease	comprehensive strength index, muscle measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0004515, EFO_0004979
Disease	1-stearoyl-2-adrenoyl-GPC (18:0/22:4) measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0800459
Disease	1-palmitoyl-2-meadoyl-GPC (16:0/20:3n9) measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0800458
Disease	phosphatidylcholine (18:0/20:5, 16:0/22:5n6) measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0800468
Disease	1-stearoyl-2-meadoyl-GPC (18:0/20:3n9) measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0800463
Disease	1-pentadecanoyl-2-arachidonoyl-GPC (15:0/20:4) measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0800446
Disease	1-palmitoyl-2-alpha-linolenoyl-GPC (16:0/18:3n3) measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0800442
Disease	1-palmitoyl-2-eicosapentaenoyl-GPC (16:0/20:5) measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0800408
Disease	phosphatidylcholine 33:2 measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0021470
Disease	phosphatidylcholine 33:1 measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0021469
Disease	1-linoleoyl-2-docosahexaenoyl-GPC (18:2/22:6) measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0022080
Disease	1-margaroyl-2-arachidonoyl-GPC (17:0/20:4) measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0022081
Disease	1-arachidoyl-2-arachidonoyl-GPC (20:0/20:4) measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0022079
Disease	1,2-dilinoleoyl-GPC (18:2/18:2) measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0800388
Disease	1-eicosapentaenoyl-GPC (20:5) measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0800355
Disease	phosphatidylcholine (O-18:1/20:4, O-16:0/22:5n3) measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0800553
Disease	1-(1-enyl-stearoyl)-GPC (P-18:0) measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0800325
Disease	1-(1-enyl-oleoyl)-GPC (P-18:1) measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0800324
Disease	1-lignoceroyl-GPC (24:0) measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0800322
Disease	1-adrenoyl-GPC (22:4) measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0800321
Disease	arachidonate 20:4n6-to-dihomo-linolenate 20:3n3 or n6 ratio	FADS1 FADS2	2.35e-05	4	59	2	EFO_0021517
Disease	fatty acid measurement, linolenic acid measurement	FADS1 FADS2	2.35e-05	4	59	2	EFO_0005110, EFO_0006811
Disease	lysophosphatidylethanolamine 20:4 measurement	FADS1 FADS2 TNKS	2.67e-05	29	59	3	EFO_0010370
Disease	lysophosphatidylcholine 20:4 measurement	FADS1 FADS2 TNKS	3.61e-05	32	59	3	EFO_0010363
Disease	phosphatidylcholine acyl-alkyl C36:5 measurement	FADS1 FADS2	3.92e-05	5	59	2	EFO_0801293
Disease	2-arachidonoyl-GPC (20:4) measurement	FADS1 FADS2	3.92e-05	5	59	2	EFO_0800237
Disease	1-arachidonoyl-GPC (20:4n6) measurement	FADS1 FADS2	3.92e-05	5	59	2	EFO_0800234
Disease	sphingomyeline C18:1 measurement	FADS1 FADS2	3.92e-05	5	59	2	EFO_0801320
Disease	1-palmitoleoyl-2-linolenoyl-GPC (16:1/18:3) measurement	FADS1 FADS2	3.92e-05	5	59	2	EFO_0800484
Disease	phosphatidylcholine (16:0/22:5n3, 18:1/20:4) measurement	FADS1 FADS2	3.92e-05	5	59	2	EFO_0800467
Disease	1-linoleoyl-GPC (18:2) measurement	FADS1 FADS2	3.92e-05	5	59	2	EFO_0800223
Disease	1-(1-enyl-stearoyl)-2-arachidonoyl-GPE (P-18:0/20:4) measurement	FADS1 FADS2	3.92e-05	5	59	2	EFO_0800415
Disease	1-palmitoyl-2-dihomo-linolenoyl-GPC (16:0/20:3n3 or 6) measurement	FADS1 FADS2	3.92e-05	5	59	2	EFO_0800407
Disease	1-(1-enyl-palmitoyl)-2-arachidonoyl-GPE (P-16:0/20:4) measurement	FADS1 FADS2	3.92e-05	5	59	2	EFO_0800417
Disease	1-linolenoyl-GPE (18:3) measurement	FADS1 FADS2	3.92e-05	5	59	2	EFO_0800365
Disease	1-(1-enyl-stearoyl)-GPE (P-18:0) measurement	FADS1 FADS2	3.92e-05	5	59	2	EFO_0800335
Disease	fatty acid measurement, docosapentaenoic acid measurement	FADS1 FADS2	3.92e-05	5	59	2	EFO_0005110, EFO_0006809
Disease	Sphingomyelin (d18:1/20:1, d18:2/20:0) measurement	FADS1 FADS2	5.87e-05	6	59	2	EFO_0022110
Disease	Sphingomyelin (d18:1/18:1, d18:2/18:0) measurement	FADS1 FADS2	5.87e-05	6	59	2	EFO_0022108
Disease	adrenate 22:4n6 measurement	FADS1 FADS2	5.87e-05	6	59	2	EFO_0021062
Disease	1-arachidonoylglycerophosphocholine measurement	FADS1 FADS2	5.87e-05	6	59	2	EFO_0021076
Disease	dihomo-linolenate 20:3n3 or n6 measurement	FADS1 FADS2	5.87e-05	6	59	2	EFO_0021046
Disease	docosapentaenoate n3 DPA; 22:5n3 measurement	FADS1 FADS2	5.87e-05	6	59	2	EFO_0021048
Disease	1-linoleoylglycerophosphoethanolamine measurement	FADS1 FADS2	5.87e-05	6	59	2	EFO_0021084
Disease	level of Phosphatidylcholine (18:2_0:0) in blood serum	FADS1 FADS2	5.87e-05	6	59	2	OBA_2045105
Disease	1-(1-enyl-stearoyl)-2-arachidonoyl-GPC (P-18:0/20:4) measurement	FADS1 FADS2	5.87e-05	6	59	2	EFO_0800394
Disease	1-palmitoyl-2-arachidonoyl-GPC (16:0/20:4n6) measurement	FADS1 FADS2	5.87e-05	6	59	2	EFO_0800390
Disease	level of Phosphatidylcholine (O-18:2_18:2) in blood serum	FADS1 FADS2	5.87e-05	6	59	2	OBA_2045134
Disease	level of Phosphatidylcholine (O-16:0_18:2) in blood serum	FADS1 FADS2	5.87e-05	6	59	2	OBA_2045114
Disease	arachidonoylcholine measurement	FADS1 FADS2	5.87e-05	6	59	2	EFO_0800478
Disease	1-oleoyl-2-docosahexaenoyl-GPE (18:1/22:6) measurement	FADS1 FADS2	5.87e-05	6	59	2	EFO_0800471
Disease	1-stearoyl-GPC (18:0) measurement	FADS1 FADS2	5.87e-05	6	59	2	EFO_0800217
Disease	1-arachidonylglycerol (20:4) measurement	FADS1 FADS2	5.87e-05	6	59	2	EFO_0800224
Disease	1-stearoyl-2-dihomo-linolenoyl-GPC (18:0/20:3n3 or 6) measurement	FADS1 FADS2	5.87e-05	6	59	2	EFO_0800434
Disease	level of Phosphatidylinositol (18:1_18:2) in blood serum	FADS1 FADS2	5.87e-05	6	59	2	OBA_2045160
Disease	1-palmitoyl-2-dihomo-linolenoyl-GPE (16:0/20:3) measurement	FADS1 FADS2	5.87e-05	6	59	2	EFO_0800444
Disease	1-palmityl-2-arachidonoyl-GPC (O-16:0/20:4) measurement	FADS1 FADS2	5.87e-05	6	59	2	EFO_0800426
Disease	1-stearoyl-2-linoleoyl-GPC (18:0/18:2) measurement	FADS1 FADS2	5.87e-05	6	59	2	EFO_0800404
Disease	lysophosphatidylcholine 18:3 measurement	FADS1 FADS2	5.87e-05	6	59	2	EFO_0021454
Disease	procollagen C-endopeptidase enhancer 1 measurement	FADS1 FADS2	5.87e-05	6	59	2	EFO_0801920
Disease	1-docosapentaenoyl-GPC (22:5n3) measurement	FADS1 FADS2	5.87e-05	6	59	2	EFO_0800298
Disease	1-(1-enyl-palmitoyl)-GPC (P-16:0) measurement	FADS1 FADS2	5.87e-05	6	59	2	EFO_0800323
Disease	level of Phosphatidylcholine (18:0_20:2) in blood serum	FADS1 FADS2	5.87e-05	6	59	2	OBA_2045092
Disease	arachidonic acid measurement, fatty acid measurement	FADS1 FADS2	5.87e-05	6	59	2	EFO_0005110, EFO_0006808
Disease	1-(1-enyl-stearoyl)-2-linoleoyl-GPE (P-18:0/18:2)* measurement	FADS1 FADS2	5.87e-05	6	59	2	EFO_0020014
Disease	arachidonate 20:4n6 measurement	FADS1 FADS2	8.20e-05	7	59	2	EFO_0021063
Disease	X-24870 measurement	FADS1 FADS2	8.20e-05	7	59	2	EFO_0022143
Disease	1-eicosatrienoylglycerophosphocholine measurement	FADS1 FADS2	8.20e-05	7	59	2	EFO_0021081
Disease	1,2-dipalmitoyl-GPC (16:0/16:0) measurement	FADS1 FADS2	8.20e-05	7	59	2	EFO_0800189
Disease	level of Phosphatidylcholine (18:2_20:3) in blood serum	FADS1 FADS2	8.20e-05	7	59	2	OBA_2045108
Disease	1-palmitoyl-2-docosahexaenoyl-GPC (16:0/22:6) measurement	FADS1 FADS2	8.20e-05	7	59	2	EFO_0800391
Disease	level of Phosphatidylcholine (O-18:2_18:1) in blood serum	FADS1 FADS2	8.20e-05	7	59	2	OBA_2045133
Disease	1-arachidonoyl-GPI (20:4) measurement	FADS1 FADS2	8.20e-05	7	59	2	EFO_0800256
Disease	level of Phosphatidylcholine (O-18:2_20:4) in blood serum	FADS1 FADS2	8.20e-05	7	59	2	OBA_2045135
Disease	1-linoleoyl-GPI (18:2) measurement	FADS1 FADS2	8.20e-05	7	59	2	EFO_0800266
Disease	1-oleoyl-2-arachidonoyl-GPE (18:1/20:4) measurement	FADS1 FADS2	8.20e-05	7	59	2	EFO_0800470
Disease	level of Sphingomyelin (d36:2) in blood serum	FADS1 FADS2	8.20e-05	7	59	2	OBA_2045177
Disease	1-oleoyl-2-linoleoyl-GPE (18:1/18:2) measurement	FADS1 FADS2	8.20e-05	7	59	2	EFO_0800443
Disease	lysophosphatidylcholine 22:4 measurement	FADS1 FADS2	8.20e-05	7	59	2	EFO_0021461
Disease	1-palmitoyl-2-linoleoyl-GPI (16:0/18:2) measurement	FADS1 FADS2	8.20e-05	7	59	2	EFO_0800609

Protein segments in the cluster

Peptide	Gene	Start	Entry
KIRPHIFFDDHMFHI	NT5C1B	576	Q96P26
FFHPPMHEYAEKLAA	AGXT2	141	Q9BYV1
ELASPHHPRMFSLQK	ARFGEF2	1101	Q9Y6D5
NFGTEMKRKALFPHH	CMTR2	336	Q8IYT2
HPTLKAIEMFHFRGP	ACOT11	261	Q8WXI4
EPKDNAMSEHLRHFP	BIRC3	216	Q13489
AMSEHLRHFPKCPFI	BIRC3	221	Q13489
VHFDKPNRKLSPAFH	RELCH	476	Q9P260
FQIEHHLFPTMPRHN	FADS2	381	O95864
HLFPTMPRHNLHKIA	FADS2	386	O95864
IHDHMNLEGKPILFF	LIPT1	51	Q9Y234
HVDDPMRFKPLFRIH	FBXO31	181	Q5XUX0
HAFAQPFAVPHSAML	PCNX3	1261	Q9H6A9
FGKHAPPAIHLLMAN	OR51M1	276	Q9H341
IIALQPALHRPMHFF	OR51S1	56	Q8NGJ8
PALHRPMHFFLFLLS	OR51S1	61	Q8NGJ8
PDFKRALGDLPHHFN	PRF1	191	P14222
NHPFVNMKHLLDFPH	HIPK3	521	Q9H422
NLHFIRFPTHDMPAF	PANK2	281	Q9BZ23
YLIHRFLFHMKPPSD	FA2H	231	Q7L5A8
FKHPHVANPRLQMAS	PCID2	31	Q5JVF3
HQMALLNFFFPDEKP	EDA	131	Q92838
HEHYIPLNLPMAFAK	DOCK11	1076	Q5JSL3
MPVPHHFFLSLKSFT	DOCK3	211	Q8IZD9
PFLPRHGHMHNNFFK	CYP17A1	41	P05093
LKRLFFFMAPPHQLE	C1orf112	501	Q9NSG2
EKHISHFMQNIPFPS	DENND4C	346	Q5VZ89
PPSMHFFQAKHLIER	ADA2	81	Q9NZK5
FQIEHHLFPTMPRHN	FADS1	381	O60427
LRHQPHFRMPFNKFI	MARF1	1271	Q9Y4F3
HFAKEANDMPKRFHP	ACOD1	146	A6NK06
PFRFDSIHPHQMLDA	DNAH9	1246	Q9NYC9
LMPEGKHNLHLRFAD	BPHL	266	Q86WA6
PQAFISPSKLHVHFM	PRDM4	596	Q9UKN5
PQFVADHPFLFLIMH	SERPINB2	386	P05120
FMAFKSFADLPHRPL	MINK1	1151	Q8N4C8
FILPAMHAALAPVFR	FUT1	111	P19526
PLLHRFSMFVRPHHK	RTEL1	1111	Q9NZ71
KFPPHRFIADQLDHL	MRPL57	81	Q9BQC6
LMHLRSFDFIHLDPF	TRMT1L	361	Q7Z2T5
FHPDGRAMATKFAHL	TBC1D25	366	Q3MII6
NPRNFKAHVSPHEML	USP39	286	Q53GS9
FFPTHMGPIKIRQFH	TAF1L	621	Q8IZX4
HLHALFMSRNPDFKG	SEC23IP	561	Q9Y6Y8
AFIFLHELHAMGKLP	CCDC146	46	Q8IYE0
KRALPHSHMPSFLAD	ARID5B	816	Q14865
PVRDPVHMYQLHKAF	CHPF	326	Q8IZ52
PRAHRMPFLEAAGHK	CHST2	361	Q9Y4C5
LAHMERKHFPPKNNA	SPATA45	81	Q537H7
PEPHARAAMFKLHLG	VPS4B	301	O75351
TMSDPHAHFNRPFLL	SERPINA11	386	Q86U17
LPPFFKHFWQHRMAL	SF3B1	811	O75533
MLFHGSPFINAIIHK	TNKS	1181	O95271
LAKFPVPELHMFDHF	ZNF592	186	Q92610
FLMPAKHQPDHAFLR	SLC4A5	996	Q9BY07
HSFVRKLAPNEFPHK	SNX27	326	Q96L92
IANHPFLFIMKHNPT	SERPINI2	366	O75830
AFVHMPTLPNLDFHK	RFX7	86	Q2KHR2
FMRSPACDIFNPLHH	PLCH1	281	Q4KWH8
FKPEMFQLHHPDPLV	PLEKHA3	181	Q9HB20
HVPASHMPLAAARFK	WDR25	121	Q64LD2
PMHSFAQLRDLHFDP	TRAPPC10	581	P48553
VILPFMKHGDLHAFL	TYRO3	601	Q06418
LLDAKHMFPVLFPFN	MYO5B	1811	Q9ULV0
THLFNAMLPFHHRDP	AMDHD2	231	Q9Y303