Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF729 ZNF355P ZNF99 ZNF718 ZNF43 ZNF595 ZNF208 ZNF621 ZNF354C ZNF674 ZNF142 ZNF225 ZNF486 ZBTB33 ZNF790

1.47e-1214122315GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF729 ZNF355P ZNF99 ZNF718 ZNF43 ZNF595 ZNF208 ZNF621 ZNF354C ZNF674 ZNF142 ZNF225 ZNF486 ZBTB33 ZNF790

2.36e-1214592315GO:0000977
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF729 ZNF355P ZNF99 ZNF718 ZNF43 ZNF595 ZNF208 ZNF621 ZNF354C ZNF225 ZNF486 ZBTB33 ZNF790

1.27e-1012442313GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF729 ZNF355P ZNF99 ZNF718 ZNF43 ZNF595 ZNF208 ZNF621 ZNF354C ZNF225 ZNF486 ZBTB33 ZNF790

1.66e-1012712313GO:0000987
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity, RNA polymerase II-specific

ZNF729 ZNF99 ZNF43 ZNF208 ZNF354C ZBTB33

1.30e-06320236GO:0001227
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity

ZNF729 ZNF99 ZNF43 ZNF208 ZNF354C ZBTB33

1.44e-06326236GO:0001217
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

ZNF729 ZNF99 ZNF43 ZNF208 ZNF225

3.77e-04560235GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

ZNF729 ZNF99 ZNF43 ZNF208 ZNF225

3.96e-04566235GO:0001216
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

ZNF729 ZNF99 ZNF43 ZNF208 PTPN11 CAMTA1

1.63e-031160236GO:0030674
GeneOntologyMolecularFunctionmolecular adaptor activity

ZNF729 ZNF99 ZNF43 ZNF208 PTPN11 CAMTA1

3.59e-031356236GO:0060090
GeneOntologyBiologicalProcesstransposable element silencing

ZNF729 ZNF99 ZNF43 ZNF208

1.86e-0746234GO:0010526
GeneOntologyBiologicalProcessretrotransposition

ZNF729 ZNF99 ZNF43 ZNF208

2.21e-0748234GO:0032197
GeneOntologyBiologicalProcesstransposition

ZNF729 ZNF99 ZNF43 ZNF208

2.61e-0750234GO:0032196
GeneOntologyBiologicalProcessnegative regulation of transcription by RNA polymerase II

ZNF729 ZNF99 ZNF43 ZNF595 ZNF208 ZNF354C ZBTB33

1.06e-041053237GO:0000122
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

ZNF729 ZNF99 ZNF43 ZNF208 ZNF142 ZNF225 CAMTA1

5.84e-041390237GO:0045944
GeneOntologyBiologicalProcessnegative regulation of DNA-templated transcription

ZNF729 ZNF99 ZNF43 ZNF595 ZNF208 ZNF354C ZBTB33

6.07e-041399237GO:0045892
GeneOntologyBiologicalProcessnegative regulation of RNA biosynthetic process

ZNF729 ZNF99 ZNF43 ZNF595 ZNF208 ZNF354C ZBTB33

6.45e-041413237GO:1902679
MousePhenodecreased eosinophil cell number

ZNF729 ZNF99 ZNF43 ZNF208

2.72e-0684174MP:0005012
MousePhenodecreased granulocyte number

ZNF729 ZNF99 SUSD6 ZNF43 ZNF208

9.85e-06254175MP:0000334
MousePhenoabnormal eosinophil morphology

ZNF729 ZNF99 ZNF43 ZNF208 LBR

1.10e-05260175MP:0005061
MousePhenoabnormal granulocyte number

ZNF729 ZNF99 SUSD6 ZNF43 ZNF208 PTPN11 LBR

2.39e-05805177MP:0020201
MousePhenoabnormal granulocyte morphology

ZNF729 ZNF99 SUSD6 ZNF43 ZNF208 PTPN11 LBR

3.03e-05835177MP:0002441
MousePhenoabnormal myeloblast morphology/development

ZNF729 ZNF99 ZNF43 ZNF208 LBR

5.28e-05360175MP:0002414
MousePhenoabnormal bone marrow cell morphology/development

ZNF729 ZNF99 ZNF43 ZNF208 PTPN11 LBR

1.24e-04706176MP:0002398
MousePhenoabnormal eosinophil cell number

ZNF729 ZNF99 ZNF43 ZNF208

2.13e-04255174MP:0002602
MousePhenoabnormal myeloid leukocyte morphology

ZNF729 ZNF99 SUSD6 ZNF43 ZNF208 PTPN11 LBR

4.80e-041292177MP:0008250
MousePhenomaternal imprinting

ZNF355P ZNF595

5.16e-0428172MP:0003122
MousePhenoabnormal lymphocyte cell number

ZNF729 ZNF99 SUSD6 ZNF43 ZNF208 PTPN11 LBR

7.50e-041390177MP:0000717
DomainKRAB

ZNF729 ZNF99 ZNF718 ZNF43 ZNF595 ZNF208 ZNF621 ZNF354C ZNF674 ZNF225 ZNF486 ZNF790

1.11e-153582212PS50805
DomainKRAB

ZNF729 ZNF99 ZNF718 ZNF43 ZNF595 ZNF208 ZNF621 ZNF354C ZNF674 ZNF225 ZNF486 ZNF790

1.11e-153582212PF01352
DomainKRAB

ZNF729 ZNF99 ZNF718 ZNF43 ZNF595 ZNF208 ZNF621 ZNF354C ZNF674 ZNF225 ZNF486 ZNF790

1.60e-153692212SM00349
DomainKRAB

ZNF729 ZNF99 ZNF718 ZNF43 ZNF595 ZNF208 ZNF621 ZNF354C ZNF674 ZNF225 ZNF486 ZNF790

1.66e-153702212IPR001909
Domainzf-C2H2

ZNF729 ZNF99 ZNF718 ZNF43 ZNF595 ZNF208 ZNF621 ZNF354C ZNF674 ZNF142 ZNF225 ZNF486 ZBTB33 ZNF790

2.00e-156932214PF00096
DomainZINC_FINGER_C2H2_2

ZNF729 ZNF99 ZNF718 ZNF43 ZNF595 ZNF208 ZNF621 ZNF354C ZNF674 ZNF142 ZNF225 ZNF486 ZBTB33 ZNF790

9.39e-157752214PS50157
DomainZINC_FINGER_C2H2_1

ZNF729 ZNF99 ZNF718 ZNF43 ZNF595 ZNF208 ZNF621 ZNF354C ZNF674 ZNF142 ZNF225 ZNF486 ZBTB33 ZNF790

9.73e-157772214PS00028
DomainZnf_C2H2

ZNF729 ZNF99 ZNF718 ZNF43 ZNF595 ZNF208 ZNF621 ZNF354C ZNF674 ZNF142 ZNF225 ZNF486 ZBTB33 ZNF790

1.59e-148052214IPR007087
DomainZnF_C2H2

ZNF729 ZNF99 ZNF718 ZNF43 ZNF595 ZNF208 ZNF621 ZNF354C ZNF674 ZNF142 ZNF225 ZNF486 ZBTB33 ZNF790

1.67e-148082214SM00355
Domain-

ZNF729 ZNF99 ZNF718 ZNF43 ZNF208 ZNF621 ZNF354C ZNF674 ZNF142 ZNF225 ZNF486 ZBTB33 ZNF790

6.37e-1467922133.30.160.60
DomainZnf_C2H2/integrase_DNA-bd

ZNF729 ZNF99 ZNF718 ZNF43 ZNF208 ZNF621 ZNF354C ZNF674 ZNF142 ZNF225 ZNF486 ZBTB33 ZNF790

8.42e-146942213IPR013087
DomainZnf_C2H2-like

ZNF729 ZNF99 ZNF718 ZNF43 ZNF208 ZNF621 ZNF354C ZNF674 ZNF142 ZNF225 ZNF486 ZBTB33 ZNF790

4.85e-137962213IPR015880
Domainzf-C2H2_6

ZNF729 ZNF99 ZNF718 ZNF43 ZNF208 ZNF621 ZNF354C ZNF225 ZNF486 ZNF790

8.46e-133142210PF13912
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

ZNF729 ZNF99 ZNF718 ZNF43 ZNF595 ZNF208 ZNF621 ZNF354C PTPN11 ZNF225 ZNF486 LBR ZNF790

1.25e-1013871713M734
PathwayREACTOME_GENERIC_TRANSCRIPTION_PATHWAY

ZNF729 ZNF355P ZNF99 ZNF43 ZNF595 ZNF208 ZNF354C PTPN11 LBR

6.61e-08768179MM14851
PathwayREACTOME_GENE_EXPRESSION_TRANSCRIPTION

ZNF729 ZNF355P ZNF99 ZNF43 ZNF595 ZNF208 ZNF354C PTPN11 LBR

7.63e-071022179MM15436
Pubmed

Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.

ZNF729 ZNF355P ZNF99 ZNF718 ZNF43 ZNF595 ZNF208

3.11e-172923714563677
Pubmed

Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.

ZNF729 ZNF355P ZNF99 ZNF43 ZNF595 ZNF208

2.05e-161523615885501
Pubmed

Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.

ZNF729 ZNF99 ZNF43 ZNF208 ZNF354C

1.02e-131323519850934
Pubmed

Functional analysis of the SRY-KRAB interaction in mouse sex determination.

ZNF729 ZNF99 ZNF43 ZNF208

3.04e-111023418588511
Pubmed

Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.

ZNF729 ZNF99 ZNF43 ZNF208

4.78e-111123415469996
Pubmed

Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.

ZNF729 ZNF355P ZNF99 ZNF43 ZNF208

1.49e-10492359630514
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZNF729 ZNF99 ZNF718 ZNF43 ZNF595 ZNF208 ZNF354C ZBTB33 ZNF790

1.15e-0980823920412781
Pubmed

Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.

ZNF99 ZNF43 ZNF208

1.41e-07162338467795
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF718 ZNF595 ZNF208 ZNF486

5.82e-0618123437372979
Pubmed

The KRAB-zinc-finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransposons.

ZNF355P ZNF595

6.26e-06623230846446
Pubmed

Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.

ZNF355P ZNF595

7.89e-05202322542606
Pubmed

Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.

ZNF355P ZNF595

7.89e-05202327479878
Pubmed

Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models.

PTPN11 LBR

2.46e-043523228106071
CytobandEnsembl 112 genes in cytogenetic band chr19p12

ZNF729 ZNF99 ZNF43 ZNF208 ZNF486

3.95e-09122235chr19p12
Cytoband19p12

ZNF729 ZNF99 ZNF208 ZNF486

1.19e-079023419p12
Cytoband4p16.3

ZNF718 ZNF595

8.36e-04852324p16.3
CytobandEnsembl 112 genes in cytogenetic band chr4p16

ZNF718 ZNF595

5.51e-03222232chr4p16
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF729 ZNF99 ZNF718 ZNF43 ZNF595 ZNF208 ZNF621 ZNF354C ZNF674 ZNF142 ZNF225 ZNF486 ZBTB33 ZNF790

1.93e-15718211428
CoexpressionTERAO_AOX4_TARGETS_SKIN_DN

ZNF729 ZNF99 ZNF43 ZNF208

9.09e-0928234MM925
CoexpressionDURAND_STROMA_NS_UP

ZNF729 ZNF99 ZNF43 ZNF208 ATRNL1

6.37e-07194235MM962
CoexpressionCOATES_MACROPHAGE_M1_VS_M2_UP

ZNF729 ZNF99 ZNF43 ZNF208

1.81e-06102234MM749
CoexpressionMIKKELSEN_NPC_ICP_WITH_H3K4ME3

ZNF729 ZNF355P ZNF99 ZNF43 ZNF595 ZNF208

3.46e-06497236MM863
CoexpressionWAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D

ZNF729 ZNF355P ZNF99 ZNF43 ZNF595 ZNF208

1.98e-05675236MM1073
CoexpressionGRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP

ZNF729 ZNF99 SUSD6 ZNF43 ZNF208 PTPN11 EOGT

6.10e-051226237MM979
CoexpressionYAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN

ZNF729 ZNF99 ZNF43 ZNF208

1.41e-04309234MM1244
ComputationalGenes in the cancer module 525.

PTPN11 LBR

1.30e-036692MODULE_525
ComputationalB lymphoma expression clusters.

PTPN11 LBR

1.90e-038092MODULE_358
ComputationalNeighborhood of RAB3A

ZNF208 ATRNL1

2.35e-038992MORF_RAB3A
ComputationalGenes in the cancer module 97.

PTPN11 LBR

2.84e-039892MODULE_97
ComputationalGenes in the cancer module 182.

PTPN11 LBR

2.96e-0310092MODULE_182
ComputationalGenes in the cancer module 262.

PTPN11 LBR

2.96e-0310092MODULE_261
ComputationalGenes in the cancer module 177.

SUSD6 LBR

3.01e-0310192MODULE_177
ComputationalNeighborhood of WNT1

ZNF208 ATRNL1

3.38e-0310792MORF_WNT1
ComputationalNeighborhood of FRK

ZNF208 ATRNL1

3.56e-0311092MORF_FRK
ComputationalNeighborhood of MAP3K14

ZNF208 ATRNL1

4.30e-0312192MORF_MAP3K14
ComputationalGenes in the cancer module 248.

PTPN11 ZBTB33

4.87e-0312992MODULE_248
ComputationalNeighborhood of LCAT

ZNF208 ATRNL1

5.17e-0313392MORF_LCAT
ComputationalNeighborhood of EPHA7

ZNF208 ATRNL1

5.63e-0313992MORF_EPHA7
Drugpisatin

CYP3A5 LBR

7.32e-0514212CID000101689
DrugOH-A

CYP3A5 LBR

8.45e-0515212CID004998669
Drugp-hydroxyphenylacetaldehyde

CYP3A5 LBR

2.21e-0424212CID000440113
Drugdiethyl phthalate

CYP3A5 LBR

2.60e-0426212CID000006781
Drugtariquidar

CYP3A5 LBR

2.80e-0427212CID000148201
Drugdimethadione

CYP3A5 LBR

3.95e-0432212CID000003081
DrugNSC325611

CYP3A5 LBR

5.88e-0439212CID000003239
DrugLisinopril [83915-83-7]; Up 200; 9uM; HL60; HT_HG-U133A

SUSD6 CYP3A5 ATRNL1

7.56e-041972132371_UP
DrugCyclopenthiazide [742-20-1]; Up 200; 10.6uM; PC3; HT_HG-U133A

ZNF208 ZNF674 ZBTB33

7.56e-041972134229_UP
Drugmorpholine

CYP3A5 LBR

7.83e-0445212CID000008083
Diseasemacrophage migration inhibitory factor measurement

ZNF43 ZNF208

3.88e-0443202EFO_0008221
DiseaseStuttering

FRMD6 ATRNL1

4.18e-03143202HP_0025268
Diseaseneutrophil-to-lymphocyte ratio

CYP3A5 PTPN11

6.90e-03185202EFO_0008447

Protein segments in the cluster

PeptideGeneStartEntry
EKLYKWKEYGKPFIC

ZNF354C

521

Q86Y25
LKYCWGYEKSCKPEF

EOGT

76

Q5NDL2
KYRKDGYCWKKRKDG

CAMTA1

116

Q9Y6Y1
GLWKFDTECYKKYGK

CYP3A5

56

P20815
CKKKYGVAWEKYCQR

LBR

591

Q14739
HSWEKKYPCRYCEKV

ZBTB33

516

Q86T24
ERGKSKCVKYWPDEY

PTPN11

361

Q06124
LYKYCPKEWKKEASK

FRMD6

76

Q96NE9
DKYWKGEACDIPYCK

ATRNL1

236

Q5VV63
KGDYKYLTCKNGEWK

SUSD6

81

Q92537
EKPYKCEECGKAFKW

ZNF99

646

A8MXY4
KPYKCEECGKAFKWS

ZNF99

731

A8MXY4
KYYKCEECGKAFKWS

ZNF718

281

Q3SXZ3
EKPYKCKECGKAFRW

ZNF595

281

Q8IYB9
KPYKCEECGKAFKWS

ZNF43

396

P17038
EKPYKCEKCGKSFRW

ZNF225

621

Q9UK10
EKPYECKVCGKAFKW

ZNF621

316

Q6ZSS3
EKPYKCEECGKAYKW

ZNF208

366

O43345
KPYKCEECGKAYKWS

ZNF208

551

O43345
EKPYKCEECGKAYKW

ZNF208

746

O43345
LYKCEECGKAYKWPS

ZNF208

1196

O43345
RKPYKCEKCGKAYIW

ZNF790

391

Q6PG37
EKPYKYQECGKAFKW

ZNF355P

181

Q9NSJ1
RKYLCPECGYKCKWV

ZNF142

1506

P52746
PECGYKCKWVNQLKY

ZNF142

1511

P52746
YVRKKDDGCKAYWKV

ZNF674

166

Q2M3X9
EKPYKCKECGKAFNW

ZNF486

431

Q96H40
EKPYKCEECGKAFKW

ZNF729

541

A6NN14
KPYKCEECGKAFKWS

ZNF729

1046

A6NN14