Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sodium:bicarbonate symporter activity	SLC4A7 SLC4A5	2.12e-04	6	76	2	GO:0008510
GeneOntologyMolecularFunction	bicarbonate transmembrane transporter activity	SLC4A7 SLC4A5 SLC4A1	2.43e-04	32	76	3	GO:0015106
GeneOntologyMolecularFunction	solute:inorganic anion antiporter activity	SLC4A7 SLC4A5 SLC4A1	2.43e-04	32	76	3	GO:0005452
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	ERCC6 CHD1 CHD2	3.75e-04	37	76	3	GO:0140658
Domain	ANION_EXCHANGER_2	SLC4A7 SLC4A5 SLC4A1	2.07e-06	7	74	3	PS00220
Domain	ANION_EXCHANGER_1	SLC4A7 SLC4A5 SLC4A1	2.07e-06	7	74	3	PS00219
Domain	Band3_cytoplasmic_dom	SLC4A7 SLC4A5 SLC4A1	4.93e-06	9	74	3	IPR013769
Domain	Band_3_cyto	SLC4A7 SLC4A5 SLC4A1	4.93e-06	9	74	3	PF07565
Domain	-	SLC4A7 SLC4A5 SLC4A1	4.93e-06	9	74	3	3.40.1100.10
Domain	HCO3_cotransp	SLC4A7 SLC4A5 SLC4A1	7.02e-06	10	74	3	PF00955
Domain	HCO3_transpt_C	SLC4A7 SLC4A5 SLC4A1	7.02e-06	10	74	3	IPR011531
Domain	PTrfase/Anion_transptr	SLC4A7 SLC4A5 SLC4A1	7.02e-06	10	74	3	IPR016152
Domain	HCO3_transpt_euk	SLC4A7 SLC4A5 SLC4A1	7.02e-06	10	74	3	IPR003020
Domain	DUF4208	CHD1 CHD2	4.63e-05	3	74	2	PF13907
Domain	DUF4208	CHD1 CHD2	4.63e-05	3	74	2	SM01176
Domain	DUF4208	CHD1 CHD2	4.63e-05	3	74	2	IPR025260
Domain	Anion_exchange	SLC4A7 SLC4A1	1.54e-04	5	74	2	IPR001717
Domain	SNF2_N	ERCC6 CHD1 CHD2	2.73e-04	32	74	3	IPR000330
Domain	SNF2_N	ERCC6 CHD1 CHD2	2.73e-04	32	74	3	PF00176
Domain	GCC2_Rab_bind	RGPD4 RGPD3	3.21e-04	7	74	2	IPR032023
Domain	Rab_bind	RGPD4 RGPD3	3.21e-04	7	74	2	PF16704
Domain	-	RGPD4 RGPD3	6.83e-04	10	74	2	1.10.220.60
Domain	PTBI	IRS4 DOK4	8.32e-04	11	74	2	SM00310
Domain	Grip	RGPD4 RGPD3	8.32e-04	11	74	2	SM00755
Domain	GRIP	RGPD4 RGPD3	8.32e-04	11	74	2	PF01465
Domain	-	RGPD4 PTPN4 IRS4 DOK4 RGPD3 PLD1 CERT1	9.01e-04	391	74	7	2.30.29.30
Domain	Ran_BP1	RGPD4 RGPD3	9.96e-04	12	74	2	PF00638
Domain	GRIP_dom	RGPD4 RGPD3	9.96e-04	12	74	2	IPR000237
Domain	GRIP	RGPD4 RGPD3	9.96e-04	12	74	2	PS50913
Domain	IRS_PTB	IRS4 DOK4	9.96e-04	12	74	2	PS51064
Domain	RANBD1	RGPD4 RGPD3	9.96e-04	12	74	2	PS50196
Domain	RanBD	RGPD4 RGPD3	1.17e-03	13	74	2	SM00160
Domain	Ran_bind_dom	RGPD4 RGPD3	1.17e-03	13	74	2	IPR000156
Domain	IRS_PTB	IRS4 DOK4	1.37e-03	14	74	2	IPR002404
Domain	IRS	IRS4 DOK4	1.37e-03	14	74	2	PF02174
Domain	PH_dom-like	RGPD4 PTPN4 IRS4 DOK4 RGPD3 PLD1 CERT1	1.48e-03	426	74	7	IPR011993
Domain	Pept_M10A_Zn_BS	MMP1 MMP16	1.57e-03	15	74	2	IPR021158
Domain	Hemopexin_CS	MMP1 MMP16	2.03e-03	17	74	2	IPR018486
Domain	Chromodomain_CS	CHD1 CHD2	2.27e-03	18	74	2	IPR023779
Domain	Pept_M10A_stromelysin-type	MMP1 MMP16	2.27e-03	18	74	2	IPR016293
Domain	PG_binding_1	MMP1 MMP16	2.81e-03	20	74	2	PF01471
Domain	Peptidoglycan-bd-like	MMP1 MMP16	2.81e-03	20	74	2	IPR002477
Domain	Hemopexin-like_dom	MMP1 MMP16	3.71e-03	23	74	2	IPR000585
Domain	Hemopexin-like_repeat	MMP1 MMP16	3.71e-03	23	74	2	IPR018487
Domain	M10A_MMP	MMP1 MMP16	3.71e-03	23	74	2	IPR033739
Domain	Hemopexin	MMP1 MMP16	3.71e-03	23	74	2	PF00045
Domain	HEMOPEXIN	MMP1 MMP16	3.71e-03	23	74	2	PS00024
Domain	-	MMP1 MMP16	3.71e-03	23	74	2	2.110.10.10
Domain	HEMOPEXIN_2	MMP1 MMP16	3.71e-03	23	74	2	PS51642
Domain	HX	MMP1 MMP16	3.71e-03	23	74	2	SM00120
Domain	Pept_M10A	MMP1 MMP16	3.71e-03	23	74	2	IPR021190
Domain	Chromo_domain	CHD1 CHD2	4.04e-03	24	74	2	IPR023780
Domain	Peptidase_M10	MMP1 MMP16	4.04e-03	24	74	2	PF00413
Domain	MetalloPept_cat_dom	ADAMTS3 MMP1 MMP16	4.08e-03	81	74	3	IPR024079
Domain	-	ADAMTS3 MMP1 MMP16	4.08e-03	81	74	3	3.40.390.10
Domain	Chromo	CHD1 CHD2	4.73e-03	26	74	2	PF00385
Domain	CHROMO_1	CHD1 CHD2	5.48e-03	28	74	2	PS00598
Domain	CHROMO_2	CHD1 CHD2	5.48e-03	28	74	2	PS50013
Domain	ZnMc	MMP1 MMP16	5.87e-03	29	74	2	SM00235
Domain	Peptidase_Metallo	MMP1 MMP16	5.87e-03	29	74	2	IPR006026
Domain	ZINC_PROTEASE	ADAMTS3 MMP1 MMP16	6.94e-03	98	74	3	PS00142
Domain	Chromodomain-like	CHD1 CHD2	7.11e-03	32	74	2	IPR016197
Domain	Chromo/shadow_dom	CHD1 CHD2	7.55e-03	33	74	2	IPR000953
Domain	CHROMO	CHD1 CHD2	7.55e-03	33	74	2	SM00298
Pathway	REACTOME_BICARBONATE_TRANSPORTERS	SLC4A7 SLC4A5 SLC4A1	7.77e-06	10	58	3	M27335
Pathway	REACTOME_BICARBONATE_TRANSPORTERS	SLC4A7 SLC4A5 SLC4A1	7.77e-06	10	58	3	MM15073
Pubmed	CHD1 and CHD2 are positive regulators of HIV-1 gene expression.	CHD1 CHD2	4.71e-06	2	76	2	25297984
Pubmed	Epicardial induction of fetal cardiomyocyte proliferation via a retinoic acid-inducible trophic factor.	KDR RXRA	4.71e-06	2	76	2	12297106
Pubmed	Phospholipase D1 and choline kinase-α are interactive targets in breast cancer.	PLD1 CHKA	4.71e-06	2	76	2	24556997
Pubmed	Promotion of cell autophagy and apoptosis in cervical cancer by inhibition of long noncoding RNA LINC00511 via transcription factor RXRA-regulated PLD1.	PLD1 RXRA	4.71e-06	2	76	2	32067228
Pubmed	Interactions between the retinoid X receptor and a conserved region of the TATA-binding protein mediate hormone-dependent transactivation.	RXRA TBP	4.71e-06	2	76	2	7667283
Pubmed	Mechanism of vitamin D3-induced transcription of phospholipase D1 in HaCat human keratinocytes.	PLD1 RXRA	1.41e-05	3	76	2	17433303
Pubmed	Vascular endothelial growth factor receptor-1 and receptor-2 initiate a phosphatidylinositide 3-kinase-dependent clonogenic response in acute myeloid leukemia cells.	PIK3C2A KDR	1.41e-05	3	76	2	15183893
Pubmed	CHD1 and SPOP synergistically protect prostate epithelial cells from DNA damage.	CHD1 CHD2	1.41e-05	3	76	2	33022763
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	TPTE EFL1 PTPN4 PDIA6 IRS4 MOSPD2 VPS33B POLR2G SHMT2 RB1CC1 ESF1	1.70e-05	1049	76	11	27880917
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	SLC4A7 VPS33B FAM210A ALDH1L2 FAM20B ZNF254 SHMT2 CHD2 MMP1 PLD1 ESF1	2.30e-05	1084	76	11	11544199
Pubmed	Human TAF(II28) promotes transcriptional stimulation by activation function 2 of the retinoid X receptors.	RXRA TBP	2.82e-05	4	76	2	8670810
Pubmed	Characterization of the CHD family of proteins.	CHD1 CHD2	2.82e-05	4	76	2	9326634
Pubmed	Genetic variants in the metzincin metallopeptidase family genes predict melanoma survival.	ADAMTS3 MMP16	2.82e-05	4	76	2	28796414
Pubmed	Matrix metalloproteinase-1-mediated up-regulation of vascular endothelial growth factor-2 in endothelial cells.	KDR MMP1	2.82e-05	4	76	2	23155052
Pubmed	Molecular expression of SLC4-derived Na+-dependent anion transporters in selected human tissues.	SLC4A7 SLC4A5	2.82e-05	4	76	2	17715183
Pubmed	Bcl3, an IkappaB protein, as a novel transcription coactivator of the retinoid X receptor.	RXRA TBP	4.69e-05	5	76	2	9812988
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RGPD4 PDIA6 IRS4 DOK4 RGPD3 DLG2 UGGT2 KDR CHD2 SPEN ESF1 MYBPC2	6.56e-05	1442	76	12	35575683
Pubmed	The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18.	RXRA TBP	7.03e-05	6	76	2	7744009
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	PDIA6 MOSPD2 SLC4A7 NDUFAF1 PIK3C2A UTP15 BACH1 SHMT2 UGGT2 CHD1 RB1CC1 ESF1	8.78e-05	1487	76	12	33957083
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	PDIA6 SLC4A7 ERCC6 PIK3C2A UTP15 RGPD3 UTP20 CHD1 CHD2 SPEN ESF1 TBP	9.35e-05	1497	76	12	31527615
Pubmed	Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.	RGPD4 RGPD3	9.83e-05	7	76	2	21205196
Pubmed	Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.	RGPD4 RGPD3	9.83e-05	7	76	2	18949001
Pubmed	An endothelial-mesenchymal relay pathway regulates early phases of pancreas development.	KDR TBP	9.83e-05	7	76	2	16386727
Pubmed	Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor.	ASXL1 RXRA	9.83e-05	7	76	2	16606617
Pubmed	Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.	RGPD4 RGPD3	9.83e-05	7	76	2	25187515
Pubmed	Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.	RGPD4 RGPD3	9.83e-05	7	76	2	9037092
Pubmed	Defects of the chorioallantoic placenta in mouse RXRalpha null fetuses.	KDR RXRA	9.83e-05	7	76	2	9356169
Pubmed	Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.	RGPD4 RGPD3	9.83e-05	7	76	2	8603673
Pubmed	Complex genomic rearrangements lead to novel primate gene function.	RGPD4 RGPD3	9.83e-05	7	76	2	15710750
Pubmed	Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).	RGPD4 RGPD3	9.83e-05	7	76	2	26632511
Pubmed	Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.	RGPD4 RGPD3	9.83e-05	7	76	2	24403063
Pubmed	Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.	RGPD4 RGPD3	9.83e-05	7	76	2	23818861
Pubmed	Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.	RGPD4 RGPD3	9.83e-05	7	76	2	11353387
Pubmed	Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.	RGPD4 RGPD3	9.83e-05	7	76	2	30944974
Pubmed	Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.	RGPD4 RGPD3	9.83e-05	7	76	2	38838144
Pubmed	Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.	RGPD4 RGPD3	9.83e-05	7	76	2	23536549
Pubmed	Retina-specifically expressed novel subtypes of bovine cyclophilin.	RGPD4 RGPD3	9.83e-05	7	76	2	7559465
Pubmed	Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.	RGPD4 RGPD3	9.83e-05	7	76	2	17372272
Pubmed	Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.	RGPD4 RGPD3	9.83e-05	7	76	2	38657106
Pubmed	Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.	RGPD4 RGPD3	9.83e-05	7	76	2	12191015
Pubmed	Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).	RGPD4 RGPD3	9.83e-05	7	76	2	22821000
Pubmed	Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.	RGPD4 RGPD3	9.83e-05	7	76	2	20682751
Pubmed	The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.	RGPD4 RGPD3	1.31e-04	8	76	2	22262462
Pubmed	The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.	RGPD4 RGPD3	1.31e-04	8	76	2	21670213
Pubmed	ZNF76, a novel transcriptional repressor targeting TATA-binding protein, is modulated by sumoylation.	PDIA6 TBP	1.31e-04	8	76	2	15280358
Pubmed	Identification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites.	MOSPD2 CERT1	1.31e-04	8	76	2	29858488
Pubmed	Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.	RGPD4 RGPD3	1.31e-04	8	76	2	28745977
Pubmed	Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.	RGPD4 RGPD3	1.31e-04	8	76	2	27412403
Pubmed	Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta.	KDR RXRA	1.31e-04	8	76	2	10385625
Pubmed	Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism.	RXRA TBP	1.31e-04	8	76	2	12040021
Pubmed	Mice lacking Ran binding protein 1 are viable and show male infertility.	RGPD4 RGPD3	1.31e-04	8	76	2	21310149
Pubmed	Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.	MMP1 CHKA MMP16 SPATA32 FGF18	1.56e-04	231	76	5	21048031
Pubmed	Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.	RGPD4 RGPD3	1.68e-04	9	76	2	18394993
Pubmed	Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD.	ADAMTS3 KDR	1.68e-04	9	76	2	27159393
Pubmed	The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.	RGPD4 RGPD3	1.68e-04	9	76	2	11553612
Pubmed	The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.	RGPD4 RGPD3	1.68e-04	9	76	2	10601307
Pubmed	The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.	RGPD4 RGPD3	1.68e-04	9	76	2	9733766
Pubmed	Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.	RGPD4 RGPD3	1.68e-04	9	76	2	28100513
Pubmed	Comparative analysis of KRAB zinc finger proteins in rodents and man: evidence for several evolutionarily distinct subfamilies of KRAB zinc finger genes.	ZNF254 ZNF681	1.68e-04	9	76	2	10360839
Pubmed	Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.	RGPD4 RGPD3	1.68e-04	9	76	2	28877029
Pubmed	Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver.	TMOD2 SLC4A1	1.68e-04	9	76	2	24159174
Pubmed	Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.	RGPD4 RGPD3	1.68e-04	9	76	2	17887960
Pubmed	NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes.	RXRA TBP	2.10e-04	10	76	2	15601870
Pubmed	Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.	RGPD4 RGPD3	2.10e-04	10	76	2	8857542
Pubmed	The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.	RGPD4 RGPD3	2.10e-04	10	76	2	27160050
Pubmed	Parkin ubiquitinates and promotes the degradation of RanBP2.	RGPD4 RGPD3	2.10e-04	10	76	2	16332688
Pubmed	Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.	RGPD4 RGPD3	2.10e-04	10	76	2	21859863
Pubmed	An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.	RGPD4 RGPD3	2.56e-04	11	76	2	35771867
Pubmed	Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation.	RXRA TBP	2.56e-04	11	76	2	10454579
Pubmed	RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.	RGPD4 RGPD3	2.56e-04	11	76	2	17069463
Pubmed	T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.	RGPD4 RGPD3	2.56e-04	11	76	2	34110283
Pubmed	FFAT motif phosphorylation controls formation and lipid transfer function of inter-organelle contacts.	MOSPD2 RB1CC1	2.56e-04	11	76	2	33124732
Pubmed	Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene).	SLC4A7 SLC4A5	3.07e-04	12	76	2	21705333
Pubmed	Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells.	PIK3C2A KDR	3.07e-04	12	76	2	14602571
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	TPTE UTP15 MAS1 KDR SPEN DYRK3	3.21e-04	420	76	6	28065597
Pubmed	Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci.	MAS1 ZNF254 ZNF681	3.29e-04	61	76	3	8662221
Pubmed	FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate.	KDR FGF18	3.62e-04	13	76	2	17014841
Pubmed	Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.	RGPD4 RGPD3	3.62e-04	13	76	2	31427429
Pubmed	Mesodermal retinoic acid signaling regulates endothelial cell coalescence in caudal pharyngeal arch artery vasculogenesis.	KDR RXRA	3.62e-04	13	76	2	22040871
Pubmed	Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network.	PDIA6 RO60 PLD1 EXTL3 PGM3	3.91e-04	282	76	5	35007762
Pubmed	Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists.	THEMIS SLC4A7	4.22e-04	14	76	2	20095854
Pubmed	Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.	RXRA TBP	4.86e-04	15	76	2	9267036
Pubmed	A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.	RXRA TBP	4.86e-04	15	76	2	10567404
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF254 ZNF681	4.86e-04	15	76	2	15885501
Pubmed	Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.	RGPD4 RGPD3	4.86e-04	15	76	2	14697343
Pubmed	The HIV-1 virion-associated protein vpr is a coactivator of the human glucocorticoid receptor.	POLR2G TBP	5.54e-04	16	76	2	9874563
Pubmed	Expression dynamics of metalloproteinases during mandibular bone formation: association with Myb transcription factor.	MMP1 MMP16	5.54e-04	16	76	2	37701782
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	IRS4 UTP15 UTP20 CHD1 CHD2 SPEN ESF1	5.68e-04	653	76	7	22586326
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	PDIA6 ERCC6 VPS33B PIK3C2A UTP15 SHMT2 UTP20 CHD1 CHD2 ESF1	7.11e-04	1353	76	10	29467282
Pubmed	Proteomic analysis identifies novel binding partners of BAP1.	ASXL1 ALDH1L2 RB1CC1	7.30e-04	80	76	3	34591877
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	VPS33B PIK3C2A DLG2 CHD2 RO60 MMP1 PLD1	7.59e-04	686	76	7	29987050
Pubmed	Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta.	KDR MMP1	7.87e-04	19	76	2	22987638
Pubmed	Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.	ZNF254 ZNF681	8.73e-04	20	76	2	7479878
Pubmed	Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.	ZNF254 ZNF681	8.73e-04	20	76	2	2542606
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	EFL1 VPS33B UTP15 RGPD3 SHMT2 UTP20 PGM3	8.82e-04	704	76	7	29955894
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	IRS4 ERCC6 RGPD3 MMP1 CERT1 DYRK3	9.14e-04	513	76	6	25798074
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	RGPD4 TPTE IRS4 PIK3C2A	1.02e-03	202	76	4	24639526
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	ERCC6 PIK3C2A KDR MMP1 RB1CC1	1.05e-03	351	76	5	20453000
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	PDIA6 IRS4 VPS33B UTP15 SHMT2 UTP20 CHD1 RO60 SPEN ESF1	1.05e-03	1425	76	10	30948266
Pubmed	HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells.	PIK3C2A KDR	1.06e-03	22	76	2	11994280
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#3_top-relative-expression-ranked_1000	PTPN4 PIK3C2A FAM210A TMOD2 CHD1 RO60 ZNF518B EXTL3 MMP16	5.36e-06	369	74	9	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k3_1000
CoexpressionAtlas	DevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#3_top-relative-expression-ranked_1000	MOSPD2 BACH1 KDR CHD2 RO60 CHKA MMP16	4.86e-05	275	74	7	gudmap_developingGonad_e14.5_ epididymis_1000_k3
CoexpressionAtlas	DevelopingGonad_e16.5_epididymis_emap-29702_k-means-cluster#2_top-relative-expression-ranked_1000	SDK2 MOSPD2 BACH1 KDR CHD2 RO60 MMP16	5.95e-05	284	74	7	gudmap_developingGonad_e16.5_epididymis_1000_k2
CoexpressionAtlas	DevelopingGonad_e18.5_ovary_emap-12283_k-means-cluster#2_top-relative-expression-ranked_1000	MOSPD2 BACH1 CHD2 RO60 CHKA MMP16	9.22e-05	210	74	6	gudmap_developingGonad_e18.5_ovary_1000_k2
CoexpressionAtlas	DevelopingGonad_e11.5_ovary + mesonephros_emap-3226_top-relative-expression-ranked_500	MOSPD2 BACH1 CHD2 RO60 CHKA MMP16 ESF1 SLC4A1	1.00e-04	417	74	8	gudmap_developingGonad_e11.5_ovary + mesonephros_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_top-relative-expression-ranked_1000	PTPN4 IRS4 ADAMTS3 PIK3C2A FAM210A TMOD2 CHD1 RO60 ZNF518B EXTL3 MMP16	1.04e-04	806	74	11	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_1000
CoexpressionAtlas	DevelopingGonad_e14.5_ ovary_emap-6699_k-means-cluster#3_top-relative-expression-ranked_1000	MOSPD2 BACH1 CHD2 RO60 CHKA MMP16	1.35e-04	225	74	6	gudmap_developingGonad_e14.5_ ovary_1000_k3
CoexpressionAtlas	DevelopingGonad_e12.5_ovary_emap-28876_k-means-cluster#3_top-relative-expression-ranked_500	MOSPD2 BACH1 CHD2 RO60 MMP16	2.49e-04	161	74	5	gudmap_developingGonad_e12.5_ovary_k3_500
CoexpressionAtlas	DevelopingGonad_e16.5_epididymis_emap-29702_k-means-cluster#2_top-relative-expression-ranked_500	MOSPD2 BACH1 CHD2 RO60 MMP16	2.56e-04	162	74	5	gudmap_developingGonad_e16.5_epididymis_500_k2
CoexpressionAtlas	DevelopingGonad_e18.5_epididymis_emap-13166_top-relative-expression-ranked_200	IRS4 BACH1 CHD2 CHKA MMP16	2.87e-04	166	74	5	gudmap_developingGonad_e18.5_epididymis_200
CoexpressionAtlas	DevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#3_top-relative-expression-ranked_1000	SLC4A7 BACH1 KDR CHD2 RO60 MMP16	2.88e-04	259	74	6	gudmap_developingGonad_e12.5_epididymis_k3_1000
Computational	Neighborhood of MYL3	KDR AMMECR1 FGF18 PGM3	2.01e-04	70	45	4	MORF_MYL3
Computational	Neighborhood of TFDP2	PIK3C2A EXTL3 RB1CC1 AMMECR1 FGF18 PGM3	3.64e-04	230	45	6	MORF_TFDP2
Computational	Neighborhood of IL16	PIK3C2A KDR RB1CC1 AMMECR1 FGF18 PGM3	4.47e-04	239	45	6	MORF_IL16
Computational	Neighborhood of PTPRB	PIK3C2A KDR RB1CC1 AMMECR1 FGF18 PGM3	6.17e-04	254	45	6	MORF_PTPRB
Computational	Neighborhood of TNFRSF6	KDR RB1CC1 AMMECR1 FGF18 PGM3	6.30e-04	167	45	5	MORF_TNFRSF6
Computational	Neighborhood of BRCA1	PIK3C2A EXTL3 RB1CC1 AMMECR1 FGF18 PGM3	7.41e-04	263	45	6	MORF_BRCA1
Computational	Neighborhood of DMPK	PIK3C2A RB1CC1 AMMECR1 FGF18 PGM3	7.79e-04	175	45	5	MORF_DMPK
Computational	Genes in the cancer module 284.	UGGT2 KDR PGM3	8.60e-04	45	45	3	MODULE_284
Computational	Neighborhood of MLLT10	PIK3C2A KDR RB1CC1 AMMECR1 FGF18 PGM3	1.51e-03	302	45	6	MORF_MLLT10
Computational	Neighborhood of ARL3	PIK3C2A KDR RB1CC1 AMMECR1 FGF18 PGM3	1.57e-03	304	45	6	MORF_ARL3
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A	MOSPD2 PELI2 DPYSL4 MMP1 CHKA MMP16 DYRK3	2.01e-06	178	75	7	5065_UP
Drug	paraldehyde	PLD1 CHKA POU2F3 SLC4A5	3.64e-06	32	75	4	CID000031264
Disease	anemia (implicated_via_orthology)	SLC4A7 SLC4A5 SLC4A1	6.21e-06	15	72	3	DOID:2355 (implicated_via_orthology)
Disease	beta-Ala-His dipeptidase measurement	ZNF254 ZNF681	1.63e-04	8	72	2	EFO_0008033
Disease	Colorectal Carcinoma	CPAMD8 IRS4 ERCC6 MYLK3 KDR CHD1 MMP1 PIK3R5	3.09e-04	702	72	8	C0009402
Disease	Non-Small Cell Lung Carcinoma	SHMT2 KDR MMP1 CERT1	5.85e-04	156	72	4	C0007131
Disease	lung cancer (is_implicated_in)	IRS4 ERCC6 MMP1	7.98e-04	74	72	3	DOID:1324 (is_implicated_in)
Disease	esophagus adenocarcinoma (is_implicated_in)	KDR MMP1	1.20e-03	21	72	2	DOID:4914 (is_implicated_in)
Disease	Arthrogryposis	ERCC6 VPS33B	1.20e-03	21	72	2	C0003886
Disease	amyotrophic lateral sclerosis (is_marker_for)	KDR MMP1	2.28e-03	29	72	2	DOID:332 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FKKTFRQYGKVLIPV	FAM210A	126	Q96ND0
KYRKFQKAFGTDRVR	BACH1	226	O14867
KKYKLSRAFVRPSGT	PGM3	486	O95394
FSYQRSLKFRPKGKT	ERVK-18	101	O42043
FKNSSYFPGKLRRVI	SLC4A1	591	P02730
RFSTGRVYFKNKLKL	ALDH1L2	11	Q3SY69
ARRGKKIFVLGPKYS	EFL1	516	Q7Z2Z2
YPRKVLNFKGKSIQR	FBXW10	851	Q5XX13
IRRFIKSYKKFGGPL	CHD1	1131	O14646
FYKLPGRISLFTLKK	ASXL1	71	Q8IXJ9
KRGSPYSLNFRVKFF	PTPN4	96	P29074
FYRKGVKAVDPKTGR	SHMT2	291	P34897
AVAKREYPKFLKRFT	CERT1	596	Q9Y5P4
KQFIRGKPIRFGYKF	ERCC6	751	P0DP91
QNRFKVPLGTKFYRV	RB1CC1	1571	Q8TDY2
KTAGVFFKPSKRKVY	OSGEPL1	6	Q9H4B0
FFKPSKRKVYEFLRS	OSGEPL1	11	Q9H4B0
NPFIYFFVGSSKKKR	MAS1	276	P04201
YFAQVVFKAKVKRRP	GPR137	116	Q96N19
KIFVKKRQEPGNYIF	KY	536	Q8NBH2
KFKLNYAVDKRGRPI	ESF1	46	Q9H501
FSPKTYSFRQDGRIK	PIK3C2A	1411	O00443
RRYKPREKLKVNFGT	MYLK3	661	Q32MK0
QKPFKYTTVTKRSRR	FGF18	186	O76093
KFTRKELQVLYRGFK	KCNIP2	101	Q9NS61
YPSLSEVFGRKRKKR	POU2F3	271	Q9UKI9
SPRKKSTRGFYFAKL	RGPD3	21	A6NKT7
RKTFPDFVYKRIKAR	DPYSL4	471	O14531
KGTFTRTPRKLGYLK	ADAMTS3	716	O15072
RSQVIKATYGRAKPF	FHAD1	496	B1AJZ9
SKIFPEYKRNLFGKF	LINC02876	76	F2Z3M2
IRRFIKAYKKFGLPL	CHD2	1136	O14647
FFRANIRKYPTKKQQ	CHKA	361	P35790
PVKRKYLFTFQGEKI	EXTL3	336	O43909
IRYSKDTRKQFKPGL	CPAMD8	346	Q8IZJ3
KLLRGTYFLRKFSKP	NDUFAF1	6	Q9Y375
PQIYTQLKGKLRKFF	CASC2	56	Q8IU53
TFKRFAPRKGDKIYQ	CNPY1	16	Q3B7I2
KKGSFVPYRDSKLTR	KIF4B	281	Q2VIQ3
KRKKSFIFSRKFPFY	DLG2	631	Q15700
LKPFTSYKFRVKATN	SDK2	1466	Q58EX2
KGFFKRTVRKDLTYT	RXRA	156	P19793
FRKSSSKGPQRLEKY	DOK4	31	Q8TEW6
SKRAKYFINSKGIPR	DYRK3	436	O43781
VLGSSKRPFQNKYFR	NUP210L	1006	Q5VU65
RYGIRGFPTIKIFQK	PDIA6	231	Q15084
AKRPNRLSFITKGYK	IRS4	886	O14654
AFKVRTTAPEKYRVK	MOSPD2	361	Q8NHP6
GRYSQEPIKTFSRFK	UTP15	66	Q8TED0
IEFLRPGYKAKRQKS	UTP20	2761	O75691
SPRKKSTRGFYFAKL	RGPD4	21	Q7Z3J3
FLKQFKTKRYFPTKV	SLC4A7	841	Q9Y6M7
KIGRGLDYFKKPQSR	MITD1	206	Q8WV92
GTRQYKFDPKTKRIL	MMP1	441	P03956
IGKPRKFSKFSLYKQ	PLD1	551	Q13393
SRFALYKRPKANGVK	PELI2	41	Q9HAT8
AFILYKFKRKRPGRT	SORCS2	1096	Q96PQ0
YFDFSKPGIKRATIK	SPATA32	321	Q96LK8
AFYKTFKTVEPTGKR	RO60	356	P10155
RKGGYKAPITNEFRK	AMMECR1	276	Q9Y4X0
KKYTKFLFVRDPFVR	CHST12	236	Q9NRB3
HFLIPTSYKGKFKRR	THEMIS	331	Q8N1K5
KFQGVKTPSQKRYVA	TPTE	381	P56180
VYTVFQFKRKGTPRH	MMP16	581	P51512
FKRYGRVESVKILPK	SPEN	26	Q96T58
KYKAIVFRPFKGEVV	POLR2G	71	P62487
RPGQKFIRIYKLFKS	PIK3R5	416	Q8WYR1
KYARVVQKLGFPAKF	TBP	236	P20226
GGQKVVFKPKRYSRD	FAM20B	116	O75063
LKKFKFSRYFPTKVR	SLC4A5	761	Q9BY07
IKDSFQKVTPRRYGK	ZNF681	91	Q96N22
KRNEFVPYKTKGARF	KDR	931	P35968
VPYKTKGARFRQGKD	KDR	936	P35968
LKKAASRTRPYLFKG	UGGT2	156	Q9NYU1
KFGYQFTKQGPRTRV	TMOD2	316	Q9NZR1
GRTRKYKVIFSPQKF	VPS33B	106	Q9H267
KVFYKFLNSNRPKIR	ZNF254	161	O75437
VNSKFKVRNFKPGKY	ZNF518B	121	Q9C0D4
RILKTGITFKPFEYK	MYBPC2	1026	Q14324