Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsteroid 11-beta-monooxygenase activity

CYP11B1 CYP11B2

4.75e-062442GO:0004507
GeneOntologyMolecularFunctioncorticosterone 18-monooxygenase activity

CYP11B1 CYP11B2

4.75e-062442GO:0047783
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

CYP11B1 CYP11B2

3.64e-0413442GO:0016713
GeneOntologyMolecularFunctioncalcium-dependent cysteine-type endopeptidase activity

CAPN15 CAPN10

6.32e-0417442GO:0004198
GeneOntologyMolecularFunctionmRNA 3'-UTR AU-rich region binding

TIA1 TIAL1

1.86e-0329442GO:0035925
GeneOntologyMolecularFunctionsteroid hydroxylase activity

CYP11B1 CYP11B2

2.55e-0334442GO:0008395
GeneOntologyMolecularFunctioncalcium channel activity

SLC24A5 TRPM8 PKD1L1

2.88e-03129443GO:0005262
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

SLC24A5 TRPM8 PKD1L1

4.47e-03151443GO:0015085
GeneOntologyMolecularFunctiontranslation initiation factor activity

EIF2S3B EIF2S3

5.65e-0351442GO:0003743
GeneOntologyMolecularFunctioniron ion binding

OGFOD3 CYP11B1 CYP11B2

5.82e-03166443GO:0005506
GeneOntologyBiologicalProcessregulation of heart rate by chemical signal

SREBF1 FFAR3 GPR42

7.03e-079433GO:0003062
GeneOntologyBiologicalProcesscellular response to peptide hormone stimulus

SREBF1 MTOR CYP11B1 FFAR3 CYP11B2 GPR42 CAPN10

1.26e-05381437GO:0071375
GeneOntologyBiologicalProcesspositive regulation of acute inflammatory response to non-antigenic stimulus

FFAR3 GPR42

1.27e-053432GO:0002879
GeneOntologyBiologicalProcessregulation of norepinephrine secretion

ADRA2B FFAR3 GPR42

2.12e-0526433GO:0014061
GeneOntologyBiologicalProcessregulation of blood volume by renal aldosterone

CYP11B1 CYP11B2

2.54e-054432GO:0002017
GeneOntologyBiologicalProcessregulation of acute inflammatory response to non-antigenic stimulus

FFAR3 GPR42

2.54e-054432GO:0002877
GeneOntologyBiologicalProcessnorepinephrine secretion

ADRA2B FFAR3 GPR42

2.67e-0528433GO:0048243
GeneOntologyBiologicalProcesshormone biosynthetic process

CYP11B1 FFAR3 CYP11B2 GPR42

2.67e-0583434GO:0042446
GeneOntologyBiologicalProcessacute inflammatory response to non-antigenic stimulus

FFAR3 GPR42

4.23e-055432GO:0002525
GeneOntologyBiologicalProcesspositive regulation of neuronal action potential

FFAR3 GPR42

6.33e-056432GO:1904457
GeneOntologyBiologicalProcessnorepinephrine transport

ADRA2B FFAR3 GPR42

6.77e-0538433GO:0015874
GeneOntologyBiologicalProcesscellular response to fatty acid

SREBF1 FFAR3 GPR42

9.15e-0542433GO:0071398
GeneOntologyBiologicalProcessresponse to peptide hormone

SREBF1 MTOR CYP11B1 FFAR3 CYP11B2 GPR42 CAPN10

1.03e-04530437GO:0043434
GeneOntologyBiologicalProcesscytoplasmic translational initiation

EIF2S3B MTOR EIF2S3

1.13e-0445433GO:0002183
GeneOntologyBiologicalProcessregulation of blood pressure

ADRA2B CYP11B1 FFAR3 CYP11B2 GPR42

1.29e-04237435GO:0008217
GeneOntologyBiologicalProcessformation of translation preinitiation complex

EIF2S3B EIF2S3

1.89e-0410432GO:0001731
GeneOntologyBiologicalProcesscortisol biosynthetic process

CYP11B1 CYP11B2

1.89e-0410432GO:0034651
GeneOntologyBiologicalProcesstertiary alcohol biosynthetic process

CYP11B1 CYP11B2

1.89e-0410432GO:1902645
GeneOntologyBiologicalProcessaldosterone biosynthetic process

CYP11B1 CYP11B2

2.31e-0411432GO:0032342
GeneOntologyBiologicalProcessorganic cation transport

ADRA2B LLGL2 FFAR3 GPR42

2.34e-04145434GO:0015695
GeneOntologyBiologicalProcesscellular response to insulin stimulus

SREBF1 MTOR FFAR3 GPR42 CAPN10

2.41e-04271435GO:0032869
GeneOntologyBiologicalProcesspositive regulation of blood pressure

ADRA2B CYP11B1 CYP11B2

2.53e-0459433GO:0045777
GeneOntologyBiologicalProcesspositive regulation of epithelial cell apoptotic process

TIA1 MTOR CAPN10

2.66e-0460433GO:1904037
GeneOntologyBiologicalProcessorganic hydroxy compound biosynthetic process

SREBF1 SLC24A5 MALRD1 CYP11B1 CYP11B2

2.67e-04277435GO:1901617
GeneOntologyBiologicalProcessketone metabolic process

SREBF1 MALRD1 MTOR CYP11B1 CYP11B2

2.76e-04279435GO:0042180
GeneOntologyBiologicalProcesscortisol metabolic process

CYP11B1 CYP11B2

2.77e-0412432GO:0034650
GeneOntologyBiologicalProcessnegative regulation of insulin secretion

SREBF1 FFAR3 GPR42

2.93e-0462433GO:0046676
GeneOntologyBiologicalProcessneuronal action potential

MTOR FFAR3 GPR42

3.07e-0463433GO:0019228
GeneOntologyBiologicalProcessmineralocorticoid biosynthetic process

CYP11B1 CYP11B2

3.26e-0413432GO:0006705
GeneOntologyBiologicalProcesspositive regulation of transmission of nerve impulse

FFAR3 GPR42

3.26e-0413432GO:0051971
GeneOntologyBiologicalProcessblood circulation

SREBF1 ADRA2B MTOR CYP11B1 FFAR3 CYP11B2 GPR42

3.52e-04648437GO:0008015
GeneOntologyBiologicalProcessregulation of catecholamine secretion

ADRA2B FFAR3 GPR42

3.68e-0467433GO:0050433
GeneOntologyBiologicalProcessprimary alcohol biosynthetic process

CYP11B1 CYP11B2

3.80e-0414432GO:0034309
GeneOntologyBiologicalProcessaldosterone metabolic process

CYP11B1 CYP11B2

3.80e-0414432GO:0032341
GeneOntologyBiologicalProcessresponse to fatty acid

SREBF1 FFAR3 GPR42

4.02e-0469433GO:0070542
GeneOntologyBiologicalProcessregulation of neuronal action potential

FFAR3 GPR42

4.38e-0415432GO:0098908
GeneOntologyBiologicalProcessprotein secretion

SREBF1 MALRD1 TVP23A FFAR3 GPR42 CAPN10

4.52e-04480436GO:0009306
GeneOntologyBiologicalProcessestablishment of protein localization to extracellular region

SREBF1 MALRD1 TVP23A FFAR3 GPR42 CAPN10

4.67e-04483436GO:0035592
GeneOntologyBiologicalProcessnegative regulation of peptide hormone secretion

SREBF1 FFAR3 GPR42

4.74e-0473433GO:0090278
GeneOntologyBiologicalProcessprotein localization to extracellular region

SREBF1 MALRD1 TVP23A FFAR3 GPR42 CAPN10

5.04e-04490436GO:0071692
GeneOntologyBiologicalProcessnegative regulation of peptide secretion

SREBF1 FFAR3 GPR42

5.13e-0475433GO:0002792
GeneOntologyBiologicalProcessmineralocorticoid metabolic process

CYP11B1 CYP11B2

5.66e-0417432GO:0008212
GeneOntologyBiologicalProcesscatecholamine secretion

ADRA2B FFAR3 GPR42

5.98e-0479433GO:0050432
GeneOntologyBiologicalProcessdrinking behavior

CYP11B1 CYP11B2

6.36e-0418432GO:0042756
GeneOntologyBiologicalProcesspositive regulation of action potential

FFAR3 GPR42

6.36e-0418432GO:0045760
GeneOntologyBiologicalProcessglucocorticoid biosynthetic process

CYP11B1 CYP11B2

6.36e-0418432GO:0006704
GeneOntologyBiologicalProcessrenal system process involved in regulation of blood volume

CYP11B1 CYP11B2

6.36e-0418432GO:0001977
GeneOntologyBiologicalProcessresponse to insulin

SREBF1 MTOR FFAR3 GPR42 CAPN10

6.99e-04342435GO:0032868
GeneOntologyBiologicalProcesscellular response to hormone stimulus

SREBF1 MTOR CYP11B1 FFAR3 CYP11B2 GPR42 CAPN10

7.00e-04727437GO:0032870
GeneOntologyBiologicalProcesscirculatory system process

SREBF1 ADRA2B MTOR CYP11B1 FFAR3 CYP11B2 GPR42

7.35e-04733437GO:0003013
GeneOntologyBiologicalProcessregulation of protein secretion

SREBF1 MALRD1 FFAR3 GPR42 CAPN10

7.75e-04350435GO:0050708
GeneOntologyBiologicalProcesscellular response to nitrogen compound

SREBF1 MTOR CYP11B1 FFAR3 CYP11B2 GPR42 CAPN10

8.54e-04752437GO:1901699
GeneOntologyBiologicalProcesschemical homeostasis

TMC8 SLC24A5 TRPM8 DMXL2 MALRD1 CYP11B1 FFAR3 CYP11B2 GPR42

9.23e-041249439GO:0048878
GeneOntologyBiologicalProcesssteroid biosynthetic process

SREBF1 MALRD1 CYP11B1 CYP11B2

9.28e-04209434GO:0006694
GeneOntologyBiologicalProcesstertiary alcohol metabolic process

CYP11B1 CYP11B2

9.55e-0422432GO:1902644
GeneOntologyBiologicalProcessnegative regulation of secretion by cell

SREBF1 ADRA2B FFAR3 GPR42

1.01e-03214434GO:1903531
GeneOntologyBiologicalProcessregulation of systemic arterial blood pressure by circulatory renin-angiotensin

CYP11B1 CYP11B2

1.04e-0323432GO:0001991
GeneOntologyBiologicalProcesscatecholamine transport

ADRA2B FFAR3 GPR42

1.05e-0396433GO:0051937
GeneOntologyBiologicalProcessresponse to hormone

SREBF1 CALCR MTOR CYP11B1 FFAR3 CYP11B2 GPR42 CAPN10

1.24e-031042438GO:0009725
GeneOntologyBiologicalProcessnegative regulation of protein secretion

SREBF1 FFAR3 GPR42

1.29e-03103433GO:0050709
GeneOntologyBiologicalProcessnegative regulation of hormone secretion

SREBF1 FFAR3 GPR42

1.29e-03103433GO:0046888
GeneOntologyBiologicalProcessC21-steroid hormone biosynthetic process

CYP11B1 CYP11B2

1.34e-0326432GO:0006700
GeneOntologyBiologicalProcessregulation of insulin secretion

SREBF1 FFAR3 GPR42 CAPN10

1.34e-03231434GO:0050796
GeneOntologyBiologicalProcesssecretion by cell

SREBF1 ADRA2B LLGL2 MALRD1 TVP23A FFAR3 GPR42 CAPN10

1.41e-031064438GO:0032940
GeneOntologyBiologicalProcessglucocorticoid metabolic process

CYP11B1 CYP11B2

1.44e-0327432GO:0008211
GeneOntologyBiologicalProcessnegative regulation of secretion

SREBF1 ADRA2B FFAR3 GPR42

1.52e-03239434GO:0051048
GeneOntologyBiologicalProcessregulation of transmission of nerve impulse

FFAR3 GPR42

1.55e-0328432GO:0051969
GeneOntologyBiologicalProcesspositive regulation of systemic arterial blood pressure

CYP11B1 CYP11B2

1.55e-0328432GO:0003084
GeneOntologyBiologicalProcesstransmission of nerve impulse

MTOR FFAR3 GPR42

1.64e-03112433GO:0019226
GeneOntologyBiologicalProcessmonoamine transport

ADRA2B FFAR3 GPR42

1.82e-03116433GO:0015844
GeneOntologyBiologicalProcessaldehyde biosynthetic process

CYP11B1 CYP11B2

1.90e-0331432GO:0046184
GeneOntologyBiologicalProcessrenal system process involved in regulation of systemic arterial blood pressure

CYP11B1 CYP11B2

1.90e-0331432GO:0003071
GeneOntologyBiologicalProcessorganic hydroxy compound metabolic process

SREBF1 SLC24A5 MALRD1 LCT CYP11B1 CYP11B2

2.02e-03641436GO:1901615
GeneOntologyBiologicalProcessnegative regulation of protein localization

SREBF1 MTOR FFAR3 GPR42

2.16e-03263434GO:1903828
GeneOntologyBiologicalProcessregulation of amine transport

ADRA2B FFAR3 GPR42

2.25e-03125433GO:0051952
GeneOntologyBiologicalProcessexport from cell

SREBF1 ADRA2B LLGL2 MALRD1 TVP23A FFAR3 GPR42 CAPN10

2.35e-031153438GO:0140352
GeneOntologyBiologicalProcessolefinic compound biosynthetic process

CYP11B1 CYP11B2

2.42e-0335432GO:0120255
GeneOntologyBiologicalProcessregulation of heart rate

SREBF1 FFAR3 GPR42

2.46e-03129433GO:0002027
GeneOntologyBiologicalProcessinsulin secretion

SREBF1 FFAR3 GPR42 CAPN10

2.50e-03274434GO:0030073
GeneOntologyBiologicalProcessregulation of hormone biosynthetic process

FFAR3 GPR42

2.56e-0336432GO:0046885
GeneOntologyBiologicalProcessregulation of peptide hormone secretion

SREBF1 FFAR3 GPR42 CAPN10

2.60e-03277434GO:0090276
GeneOntologyBiologicalProcesstranslational initiation

EIF2S3B MTOR EIF2S3

2.62e-03132433GO:0006413
GeneOntologyBiologicalProcessregulation of systemic arterial blood pressure by renin-angiotensin

CYP11B1 CYP11B2

2.70e-0337432GO:0003081
GeneOntologyBiologicalProcessregulation of peptide transport

SREBF1 FFAR3 GPR42 CAPN10

2.78e-03282434GO:0090087
GeneOntologyBiologicalProcessregulation of peptide secretion

SREBF1 FFAR3 GPR42 CAPN10

2.78e-03282434GO:0002791
GeneOntologyBiologicalProcessregulation of hormone levels

SREBF1 CYP11B1 FFAR3 CYP11B2 GPR42 CAPN10

2.79e-03684436GO:0010817
GeneOntologyBiologicalProcesschemokine production

SLAMF9 FFAR3 GPR42

2.79e-03135433GO:0032602
GeneOntologyCellularComponenteukaryotic translation initiation factor 2 complex

EIF2S3B EIF2S3

6.46e-056442GO:0005850
HumanPhenoSecretory adrenocortical adenoma

CYP11B1 CYP11B2

3.53e-053182HP:0011746
HumanPhenoDexamethasone-suppressible primary hyperaldosteronism

CYP11B1 CYP11B2

1.17e-045182HP:0011739
HumanPhenoLactose intolerance

LCT MTOR

1.17e-045182HP:0004789
MousePhenoabnormal urine progesterone level

CYP11B1 CYP11B2

7.20e-062382MP:0011545
MousePhenoabnormal urine deoxycorticosterone level

CYP11B1 CYP11B2

7.20e-062382MP:0011552
MousePhenodecreased urine corticosterone level

CYP11B1 CYP11B2

7.20e-062382MP:0011550
MousePhenoincreased urine deoxycorticosterone level

CYP11B1 CYP11B2

7.20e-062382MP:0011553
MousePhenoincreased urine progesterone level

CYP11B1 CYP11B2

7.20e-062382MP:0011546
MousePhenodecreased lipid level

SREBF1 DMXL2 LLGL2 MALRD1 TIAL1 MTOR CYP11B1 FFAR3 CYP11B2 GPR42

1.70e-057273810MP:0014461
MousePhenoabnormal sympathetic neuron innervation pattern

FFAR3 GPR42

2.15e-053382MP:0009284
MousePhenoabnormal adrenal gland zona glomerulosa morphology

CYP11B1 CYP11B2

4.30e-054382MP:0008293
MousePhenodecreased urine aldosterone level

CYP11B1 CYP11B2

4.30e-054382MP:0011541
MousePhenoabnormal urine aldosterone level

CYP11B1 CYP11B2

4.30e-054382MP:0011539
MousePhenoabnormal sympathetic neuron physiology

FFAR3 GPR42

4.30e-054382MP:0009253
MousePhenoabnormal urine corticosterone level

CYP11B1 CYP11B2

4.30e-054382MP:0011548
MousePhenodecreased urine hormone level

CYP11B1 CYP11B2

4.30e-054382MP:0014459
MousePhenoincreased adrenal gland zona fasciculata size

CYP11B1 CYP11B2

7.16e-055382MP:0014286
MousePhenouterus adenomyosis

CYP11B1 CYP11B2

1.07e-046382MP:0009221
MousePhenoincreased urine hormone level

CYP11B1 CYP11B2

1.07e-046382MP:0014458
MousePhenoadrenal gland hyperplasia

CYP11B1 CYP11B2

1.07e-046382MP:0009078
MousePhenodecreased circulating noradrenaline level

FFAR3 GPR42

1.50e-047382MP:0005664
MousePhenoabnormal urine hormone level

CYP11B1 CYP11B2

1.50e-047382MP:0011538
MousePhenopituitary gland hyperplasia

CYP11B1 CYP11B2

1.50e-047382MP:0000635
MousePhenoincreased circulating ketone body level

SREBF1 FFAR3 GPR42

1.58e-0439383MP:0002575
MousePhenoincreased circulating angiotensin II level

CYP11B1 CYP11B2

1.99e-048382MP:0031232
MousePhenoincreased angiotensin II level

CYP11B1 CYP11B2

1.99e-048382MP:0031229
MousePhenoketosis

SREBF1 FFAR3 GPR42

2.12e-0443383MP:0030970
MousePhenodecreased circulating renin level

CYP11B1 CYP11B2

3.19e-0410382MP:0003353
MousePhenoabnormal adrenocortical cell morphology

CYP11B1 CYP11B2

3.19e-0410382MP:0008291
MousePhenoenlarged kidney

TMEM150B FDX2 CYP11B1 FFAR3 CYP11B2 GPR42

3.52e-04354386MP:0003068
MousePhenoabnormal adrenal gland zona fasciculata size

CYP11B1 CYP11B2

3.90e-0411382MP:0014284
MousePhenoabnormal sympathetic neuron morphology

FFAR3 GPR42

3.90e-0411382MP:0001025
MousePhenouterus cyst

CYP11B1 CYP11B2

3.90e-0411382MP:0009082
MousePhenoabnormal circulating ketone body level

SREBF1 FFAR3 GPR42

4.18e-0454383MP:0003457
MousePhenoabnormal circulating angiotensin II level

CYP11B1 CYP11B2

4.67e-0412382MP:0031230
MousePhenoabnormal angiotensin II level

CYP11B1 CYP11B2

4.67e-0412382MP:0031227
MousePhenohypokalemia

CYP11B1 CYP11B2

4.67e-0412382MP:0004119
MousePhenoenlarged pituitary gland

CYP11B1 CYP11B2

4.67e-0412382MP:0000636
MousePhenoabnormal pituitary gland morphology

CUL9 DMXL2 CYP11B1 CYP11B2

4.76e-04135384MP:0000633
MousePhenoabnormal noradrenaline level

LRTM2 FFAR3 GPR42

6.27e-0462383MP:0003964
MousePhenoincreased renin activity

CYP11B1 CYP11B2

6.41e-0414382MP:0005582
MousePhenodecreased circulating mineralocorticoid level

CYP11B1 CYP11B2

6.41e-0414382MP:0003374
MousePhenoincreased urine osmolality

CYP11B1 CYP11B2

6.41e-0414382MP:0008055
MousePhenoincreased circulating adrenocorticotropin level

CYP11B1 CYP11B2

6.41e-0414382MP:0001748
MousePhenodecreased circulating aldosterone level

CYP11B1 CYP11B2

6.41e-0414382MP:0002667
MousePhenoendometrium hyperplasia

CYP11B1 CYP11B2

6.41e-0414382MP:0009092
MousePhenodecreased circulating cholesterol level

SREBF1 DMXL2 LLGL2 MALRD1 TIAL1 MTOR

6.46e-04397386MP:0005179
MousePhenoabnormal neuroendocrine gland morphology

CUL9 DMXL2 CYP11B1 CYP11B2

8.20e-04156384MP:0000631
MousePhenodecreased cholesterol level

SREBF1 DMXL2 LLGL2 MALRD1 TIAL1 MTOR

8.45e-04418386MP:0003983
MousePhenodecreased sterol level

SREBF1 DMXL2 LLGL2 MALRD1 TIAL1 MTOR

8.78e-04421386MP:0012225
MousePhenoabnormal intestinal transit time

FFAR3 GPR42

9.54e-0417382MP:0006001
MousePhenoabnormal adrenal gland zona fasciculata morphology

CYP11B1 CYP11B2

1.20e-0319382MP:0008294
MousePhenoabnormal circulating noradrenaline level

FFAR3 GPR42

1.20e-0319382MP:0005663
MousePhenoabnormal diencephalon morphology

CUL9 DMXL2 MTOR CYP11B1 CYP11B2

1.20e-03298385MP:0000830
MousePhenoabnormal renin activity

CYP11B1 CYP11B2

1.33e-0320382MP:0005581
MousePhenoincreased adrenocorticotropin level

CYP11B1 CYP11B2

1.61e-0322382MP:0005129
MousePhenoincreased circulating renin level

CYP11B1 CYP11B2

1.76e-0323382MP:0003352
MousePhenooliguria

CYP11B1 CYP11B2

1.91e-0324382MP:0003620
MousePhenopostnatal lethality, incomplete penetrance

SREBF1 LLGL2 TIA1 TIAL1 CYP11B1 CYP11B2 PKD1L1

1.92e-03669387MP:0011086
MousePhenodecreased noradrenaline level

FFAR3 GPR42

2.08e-0325382MP:0012574
MousePhenodecreased liver triglyceride level

SREBF1 FFAR3 GPR42

2.09e-0394383MP:0009356
MousePhenohypotension

CYP11B1 CYP11B2

2.60e-0328382MP:0001596
MousePhenoabnormal circulating renin level

CYP11B1 CYP11B2

2.79e-0329382MP:0003349
MousePhenoabnormal sympathetic nervous system physiology

FFAR3 GPR42

2.79e-0329382MP:0004183
MousePhenoabnormal cholesterol homeostasis

SREBF1 CMPK2 DMXL2 LLGL2 MALRD1 TIAL1 MTOR CAPN10

3.16e-03936388MP:0005278
DomainCyt_P450_mitochondrial

CYP11B1 CYP11B2

5.18e-062432IPR002399
DomainGPR40-rel_orph

FFAR3 GPR42

3.10e-054432IPR013312
DomainCalpain_cysteine_protease

CAPN15 CAPN10

4.63e-0414432IPR022684
DomainCysPc

CAPN15 CAPN10

5.33e-0415432SM00230
DomainPeptidase_C2_calpain_cat

CAPN15 CAPN10

5.33e-0415432IPR001300
DomainPeptidase_C2

CAPN15 CAPN10

5.33e-0415432PF00648
DomainCALPAIN_CAT

CAPN15 CAPN10

5.33e-0415432PS50203
DomainRRM_dom_euk

TIA1 TIAL1

1.27e-0323432IPR003954
DomainRRM_1

TIA1 TIAL1

1.27e-0323432SM00361
DomainTHIOL_PROTEASE_CYS

CAPN15 CAPN10

1.62e-0326432PS00139
DomainTHIOL_PROTEASE_ASN

CAPN15 CAPN10

1.75e-0327432PS00640
DomainTHIOL_PROTEASE_HIS

CAPN15 CAPN10

1.75e-0327432PS00639
DomainPept_cys_AS

CAPN15 CAPN10

1.88e-0328432IPR000169
DomainCyt_P450_CS

CYP11B1 CYP11B2

6.62e-0353432IPR017972
PathwayBIOCARTA_IGF1MTOR_PATHWAY

EIF2S3B MTOR EIF2S3

9.68e-0620303MM1496
PathwayREACTOME_ENDOGENOUS_STEROLS

FDX2 CYP11B1 CYP11B2

1.94e-0525303M11184
PathwayREACTOME_ENDOGENOUS_STEROLS

FDX2 CYP11B1 CYP11B2

2.46e-0527303MM14844
PathwayKEGG_MEDICUS_REFERENCE_STEROID_HORMONE_BIOSYNTHESIS_PROGESTERONE_TO_CORTISOL_CORTISONE

CYP11B1 CYP11B2

4.36e-055302M47522
PathwayREACTOME_METABOLIC_DISORDERS_OF_BIOLOGICAL_OXIDATION_ENZYMES

FDX2 CYP11B1 CYP11B2

4.98e-0534303M27461
PathwayREACTOME_METABOLISM_OF_STEROID_HORMONES

FDX2 CYP11B1 CYP11B2

5.92e-0536303M27081
PathwayREACTOME_METABOLISM_OF_STEROID_HORMONES

FDX2 CYP11B1 CYP11B2

8.78e-0541303MM14757
PathwayREACTOME_METABOLISM_OF_STEROIDS

SREBF1 FDX2 CYP11B1 CYP11B2

1.39e-04126304MM15553
PathwayREACTOME_RECYCLING_OF_EIF2_GDP

EIF2S3B EIF2S3

1.56e-049302MM15418
PathwayBIOCARTA_EIF2_PATHWAY

EIF2S3B EIF2S3

1.95e-0410302MM1469
PathwayREACTOME_CELLULAR_RESPONSE_TO_MITOCHONDRIAL_STRESS

EIF2S3B EIF2S3

1.95e-0410302MM17234
PathwayREACTOME_GLUCOCORTICOID_BIOSYNTHESIS

CYP11B1 CYP11B2

1.95e-0410302M27076
PathwayBIOCARTA_EIF_PATHWAY

EIF2S3B EIF2S3

1.95e-0410302MM1394
PathwayREACTOME_GLUCOCORTICOID_BIOSYNTHESIS

CYP11B1 CYP11B2

2.38e-0411302MM14750
PathwayWP_SREBF_AND_MIR33_IN_CHOLESTEROL_AND_LIPID_HOMEOSTASIS

SREBF1 MTOR

2.85e-0412302MM15927
PathwayREACTOME_UNFOLDED_PROTEIN_RESPONSE_UPR

EIF2S3B EIF2S3

2.85e-0412302MM14981
PathwayREACTOME_MINERALOCORTICOID_BIOSYNTHESIS

CYP11B1 CYP11B2

2.85e-0412302MM14749
PathwayREACTOME_METABOLISM_OF_STEROIDS

SREBF1 FDX2 CYP11B1 CYP11B2

3.01e-04154304M27832
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

FDX2 CYP11B1 CYP11B2

3.32e-0464303M5650
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

FDX2 CYP11B1 CYP11B2

3.64e-0466303MM14839
PathwayWP_GLUCOCORTICOID_BIOSYNTHESIS

CYP11B1 CYP11B2

3.92e-0414302M46449
PathwayWP_MINERALOCORTICOID_BIOSYNTHESIS

CYP11B1 CYP11B2

3.92e-0414302M46453
PathwayWP_CLASSICAL_PATHWAY_OF_STEROIDOGENESIS_WITH_GLUCOCORTICOID_AND_MINERALOCORTICOID_METABOLISM

CYP11B1 CYP11B2

5.16e-0416302M39815
PathwayWP_SREBF_AND_MIR33_IN_CHOLESTEROL_AND_LIPID_HOMEOSTASIS

SREBF1 MTOR

6.56e-0418302M39679
PathwayBIOCARTA_IGF1MTOR_PATHWAY

MTOR EIF2S3

7.32e-0419302M16991
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

FDX2 CYP11B1 CYP11B2

1.37e-03104303M738
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

FDX2 CYP11B1 CYP11B2

1.41e-03105303MM14842
PathwayREACTOME_FGFR2_ALTERNATIVE_SPLICING

TIA1 TIAL1

1.49e-0327302M27632
PathwayWP_CHOLESTEROL_BIOSYNTHESIS_PATHWAY_IN_HEPATOCYTES

SREBF1 CYP11B1 CYP11B2

1.65e-03111303M48065
PathwayREACTOME_DISEASES_OF_METABOLISM

LCT FDX2 CYP11B1 CYP11B2

1.84e-03250304M27554
PathwayWP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS

MTOR FFAR3

2.09e-0332302M39893
PathwayWP_GPCRS_NONODORANT

ADRA2B CALCR FFAR3 GPR42

2.31e-03266304MM15843
Pubmed

Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia.

FFAR3 GPR42

1.64e-06245225637492
Pubmed

iCLIP predicts the dual splicing effects of TIA-RNA interactions.

TIA1 TIAL1

1.64e-06245221048981
Pubmed

Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study.

CYP11B1 CYP11B2

1.64e-06245217651452
Pubmed

Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension.

CYP11B1 CYP11B2

1.64e-06245223150505
Pubmed

Expression of CYP11B1 and CYP11B2 in adrenal adenoma correlates with clinical characteristics of primary aldosteronism.

CYP11B1 CYP11B2

1.64e-06245234743356
Pubmed

GRAde: a long-read sequencing approach to efficiently identifying the CYP11B1/CYP11B2 chimeric form in patients with glucocorticoid-remediable aldosteronism.

CYP11B1 CYP11B2

1.64e-06245235012455
Pubmed

Role of genetic variation in regulation of aldosterone biosynthesis.

CYP11B1 CYP11B2

1.64e-06245221164264
Pubmed

Selective tracking of FFAR3-expressing neurons supports receptor coupling to N-type calcium channels in mouse sympathetic neurons.

FFAR3 GPR42

1.64e-06245230478340
Pubmed

3-(4-Hydroxy-3-methoxyphenyl) propionic acid contributes to improved hepatic lipid metabolism via GPR41.

FFAR3 GPR42

1.64e-06245238040866
Pubmed

Identification of chosen apoptotic (TIAR and TIA-1) markers expression in thyroid tissues from adolescents with immune and non-immune thyroid diseases.

TIA1 TIAL1

1.64e-06245220675271
Pubmed

Polymorphisms in CYP11B2 and CYP11B1 genes associated with primary hyperaldosteronism.

CYP11B1 CYP11B2

1.64e-06245220339375
Pubmed

Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APPswe Alzheimer's Disease Mouse Model.

FFAR3 GPR42

1.64e-06245235408893
Pubmed

FFAR3 modulates insulin secretion and global gene expression in mouse islets.

FFAR3 GPR42

1.64e-06245226091414
Pubmed

TIA-1 and TIAR activate splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on their own pre-mRNAs.

TIA1 TIAL1

1.64e-06245211514562
Pubmed

Genetic analyses of the chimeric CYP11B1/CYP11B2 gene in a Korean family with glucocorticoid-remediable aldosteronism.

CYP11B1 CYP11B2

1.64e-06245220808686
Pubmed

GPR41 modulates insulin secretion and gene expression in pancreatic β-cells and modifies metabolic homeostasis in fed and fasting states.

FFAR3 GPR42

1.64e-06245227550964
Pubmed

The hamster adrenal cytochrome P450C11 has equipotent 11beta-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity.

CYP11B1 CYP11B2

1.64e-0624528645611
Pubmed

Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein.

TIA1 TIAL1

1.64e-06245217488725
Pubmed

Intestinal FFA3 mediates obesogenic effects in mice on a Western diet.

FFAR3 GPR42

1.64e-06245235858247
Pubmed

Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms.

FFAR3 GPR42

1.64e-06245222506074
Pubmed

Free fatty acid receptor 3 differentially contributes to β-cell compensation under high-fat diet and streptozotocin stress.

FFAR3 GPR42

1.64e-06245232073900
Pubmed

Expression and localization of cytochrome P450(11beta,aldo) mRNA in the frog brain.

CYP11B1 CYP11B2

1.64e-06245212231255
Pubmed

A de novo unequal cross-over mutation between CYP11B1 and CYP11B2 genes causes familial hyperaldosteronism type I.

CYP11B1 CYP11B2

1.64e-06245220634641
Pubmed

Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase.

CYP11B1 CYP11B2

1.64e-0624521303253
Pubmed

Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets.

CYP11B1 CYP11B2

1.64e-06245221519965
Pubmed

Diagnosis of glucocorticoid-remediable aldosteronism in hypertensive children.

CYP11B1 CYP11B2

1.64e-06245221625068
Pubmed

Genetic screening for glucocorticoid-remediable aldosteronism (GRA): experience of three clinical centres in Poland.

CYP11B1 CYP11B2

1.64e-06245216110193
Pubmed

Chimeric CYP11B2/CYP11B1 causing 11β-hydroxylase deficiency in Chinese patients with congenital adrenal hyperplasia.

CYP11B1 CYP11B2

1.64e-06245226066897
Pubmed

The effects of propionate and valerate on insulin responsiveness for glucose uptake in 3T3-L1 adipocytes and C2C12 myotubes via G protein-coupled receptor 41.

FFAR3 GPR42

1.64e-06245224748202
Pubmed

The stress granule component TIA-1 binds tick-borne encephalitis virus RNA and is recruited to perinuclear sites of viral replication to inhibit viral translation.

TIA1 TIAL1

1.64e-06245224696465
Pubmed

The Cognitive Improvement and Alleviation of Brain Hypermetabolism Caused by FFAR3 Ablation in Tg2576 Mice Is Persistent under Diet-Induced Obesity.

FFAR3 GPR42

1.64e-06245236362376
Pubmed

T-cell intracellular antigen (TIA)-proteins deficiency in murine embryonic fibroblasts alters cell cycle progression and induces autophagy.

TIA1 TIAL1

1.64e-06245224086455
Pubmed

Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.

CYP11B1 CYP11B2

1.64e-0624521741400
Pubmed

Effects of intron conversion in the human CYP11B2 gene on its transcription and blood pressure regulation in transgenic mice.

CYP11B1 CYP11B2

1.64e-06245232540969
Pubmed

Inhibition of aldosterone synthase (CYP11B2) by torasemide prevents atrial fibrosis and atrial fibrillation in mice.

CYP11B1 CYP11B2

1.64e-06245226047574
Pubmed

Aldosterone synthase knockout mouse as a model for sodium-induced endothelial sodium channel up-regulation in vascular endothelium.

CYP11B1 CYP11B2

1.64e-06245226324851
Pubmed

Cytotoxicity and decreased corticosterone production in adrenocortical Y-1 cells by 3-methylsulfonyl-DDE and structurally related molecules.

CYP11B1 CYP11B2

1.64e-06245218651133
Pubmed

Microsatellite polymorphism analysis allows the individual assignment of the rat 11 beta-hydroxylase gene (Cyp11b1) and the rat aldosterone synthase gene (Cyp11b2) to chromosome 7 using rat x mouse somatic cell hybrids and identifies differences between and within various rat strains.

CYP11B1 CYP11B2

1.64e-0624527669222
Pubmed

A new presentation of the chimeric CYP11B1/CYP11B2 gene with low prevalence of primary aldosteronism and atypical gene segregation pattern.

CYP11B1 CYP11B2

1.64e-06245222083159
Pubmed

Genome-wide profiling reveals a role for T-cell intracellular antigens TIA1 and TIAR in the control of translational specificity in HeLa cells.

TIA1 TIAL1

1.64e-06245224927121
Pubmed

Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron.

CYP11B1 CYP11B2

1.64e-06245222933298
Pubmed

Splicing of the large intron present in the nonstructural gene of minute virus of mice is governed by TIA-1/TIAR binding downstream of the nonconsensus donor.

TIA1 TIAL1

1.64e-06245219339348
Pubmed

Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids.

FFAR3 GPR42

1.64e-06245220399779
Pubmed

Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42.

FFAR3 GPR42

1.64e-06245219630535
Pubmed

Structural and functional analysis of the promoter region of the gene encoding mouse steroid 11 beta-hydroxylase.

CYP11B1 CYP11B2

1.64e-0624522783417
Pubmed

Structure, tissue distribution and genomic organization of the murine RRM-type RNA binding proteins TIA-1 and TIAR.

TIA1 TIAL1

1.64e-0624528871565
Pubmed

Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism.

CYP11B1 CYP11B2

1.64e-0624522256920
Pubmed

Identification of the sequence determinants mediating the nucleo-cytoplasmic shuttling of TIAR and TIA-1 RNA-binding proteins.

TIA1 TIAL1

1.64e-06245216278295
Pubmed

Editorial: polymorphisms in CYP11B genes and 11-hydroxylase activity.

CYP11B1 CYP11B2

1.64e-06245215699546
Pubmed

Cyp11b1 is induced in the murine gonad by luteinizing hormone/human chorionic gonadotropin and involved in the production of 11-ketotestosterone, a major fish androgen: conservation and evolution of the androgen metabolic pathway.

CYP11B1 CYP11B2

1.64e-06245218162527
Pubmed

Chronic activation of adrenal Gq signaling induces Cyp11b2 expression in the zona fasciculata and hyperaldosteronism.

CYP11B1 CYP11B2

1.64e-06245238341019
Pubmed

Association of DNA polymorphisms within the CYP11B2/CYP11B1 locus and postoperative hypertension risk in the patients with aldosterone-producing adenomas.

CYP11B1 CYP11B2

1.64e-06245220708777
Pubmed

Molecular genetic studies on the biosynthesis of aldosterone in humans.

CYP11B1 CYP11B2

1.64e-06245222217843
Pubmed

Mechanistic study of polychlorinated biphenyl 126-induced CYP11B1 and CYP11B2 up-regulation.

CYP11B1 CYP11B2

1.64e-06245216396990
Pubmed

Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies.

CYP11B1 CYP11B2

1.64e-06245224837548
Pubmed

Aldosterone deficiency in mice burdens respiration and accentuates diet-induced hyperinsulinemia and obesity.

CYP11B1 CYP11B2

1.64e-06245230046010
Pubmed

Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content.

FFAR3 GPR42

1.64e-06245223110765
Pubmed

Familial and phenotypic associations of the aldosterone Renin ratio.

CYP11B1 CYP11B2

1.64e-06245219820005
Pubmed

Individual RNA recognition motifs of TIA-1 and TIAR have different RNA binding specificities.

TIA1 TIAL1

1.64e-0624528576255
Pubmed

The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation.

FFAR3 GPR42

1.64e-06245226522986
Pubmed

TIAR and TIA-1 mRNA-binding proteins co-aggregate under conditions of rapid oxygen decline and extreme hypoxia and suppress the HIF-1α pathway.

TIA1 TIAL1

1.64e-06245220980400
Pubmed

[123 I]Iodometomidate for molecular imaging of adrenocortical cytochrome P450 family 11B enzymes.

CYP11B1 CYP11B2

1.64e-06245218397978
Pubmed

Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.

CYP11B1 CYP11B2

1.64e-0624521518866
Pubmed

Regulation of SREBP1c expression by mTOR signaling in hepatocytes.

SREBF1 MTOR

1.64e-06245220847591
Pubmed

Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.

FFAR3 GPR42

1.64e-06245214722361
Pubmed

Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41.

FFAR3 GPR42

1.64e-06245227664183
Pubmed

Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury.

CYP11B1 CYP11B2

1.64e-06245222622494
Pubmed

A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation.

TIA1 TIAL1

1.64e-06245218456862
Pubmed

Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18-hydroxycortisol production.

CYP11B1 CYP11B2

1.64e-06245215062555
Pubmed

Insulin-induced de novo lipid synthesis occurs mainly via mTOR-dependent regulation of proteostasis of SREBP-1c.

SREBF1 MTOR

1.64e-06245231541353
Pubmed

Procollagen I-expressing renin cell precursors.

CYP11B1 CYP11B2

1.64e-06245223761669
Pubmed

Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption.

CYP11B1 CYP11B2

1.64e-06245217075030
Pubmed

Polymorphic variation in the 11beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency.

CYP11B1 CYP11B2

1.64e-06245217075029
Pubmed

Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).

CYP11B1 CYP11B2

1.64e-0624522592361
Pubmed

CYP11B2-CYP11B1 haplotypes associated with decreased 11 beta-hydroxylase activity.

CYP11B1 CYP11B2

1.64e-06245215507509
Pubmed

Polymorphism of CYP11B2 determines salt sensitivity in Japanese.

CYP11B1 CYP11B2

1.64e-06245217296872
Pubmed

Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in mice.

CYP11B1 CYP11B2

1.64e-06245223314847
Pubmed

Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects.

CYP11B1 CYP11B2

1.64e-06245217980006
Pubmed

Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene.

CYP11B1 CYP11B2

1.64e-06245216984984
Pubmed

Evidence for local aldosterone synthesis in the large intestine of the mouse.

CYP11B1 CYP11B2

1.64e-06245235288482
Pubmed

Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice.

CYP11B1 CYP11B2

1.64e-06245215731365
Pubmed

Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase.

CYP11B1 CYP11B2

1.64e-06245218039983
Pubmed

Cyp11b1 null mouse, a model of congenital adrenal hyperplasia.

CYP11B1 CYP11B2

1.64e-06245219029289
Pubmed

Structure of the central RNA recognition motif of human TIA-1 at 1.95A resolution.

TIA1 TIAL1

1.64e-06245218201561
Pubmed

TIA-1 and TIAR interact with 5'-UTR of enterovirus 71 genome and facilitate viral replication.

TIA1 TIAL1

1.64e-06245226363455
Pubmed

TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha.

TIA1 TIAL1

1.64e-06245210921895
Pubmed

Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed.

FFAR3 GPR42

1.64e-06245226260360
Pubmed

G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gαi/o and downstream Smad2/3 and ERK1/2 phosphorylation.

FFAR3 GPR42

1.64e-06245237019194
Pubmed

Sexually dimorphic expression of the X-linked gene Eif2s3x mRNA but not protein in mouse brain.

EIF2S3B EIF2S3

1.64e-06245216325480
Pubmed

Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion.

CYP11B1 CYP11B2

1.64e-06245215522937
Pubmed

Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation.

FFAR3 GPR42

4.91e-06345222673524
Pubmed

Immune escape of colorectal tumours via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids.

CYP11B1 CYP11B2

4.91e-06345236861295
Pubmed

SREBF1 Activity Is Regulated by an AR/mTOR Nuclear Axis in Prostate Cancer.

SREBF1 MTOR

4.91e-06345229784665
Pubmed

Adrenal-Specific KO of the Circadian Clock Protein BMAL1 Alters Blood Pressure Rhythm and Timing of Eating Behavior.

CYP11B1 CYP11B2

4.91e-06345236778748
Pubmed

Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain.

CYP11B1 CYP11B2

4.91e-0634528111631
Pubmed

The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells.

CYP11B1 CYP11B2

4.91e-0634522546938
Pubmed

Kidney function in mice lacking aldosterone.

CYP11B1 CYP11B2

4.91e-06345216118390
Pubmed

The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.

FFAR3 GPR42

4.91e-06345212496283
Pubmed

mTOR Driven Gene Transcription Is Required for Cholesterol Production in Neurons of the Developing Cerebral Cortex.

SREBF1 MTOR

4.91e-06345234204880
Pubmed

Interaction of CYP11B1 (cytochrome P-45011 beta) with CYP11A1 (cytochrome P-450scc) in COS-1 cells.

CYP11B1 CYP11B2

4.91e-06345210411633
CytobandEnsembl 112 genes in cytogenetic band chr17q25

TMC8 OGFOD3 MYO15B LLGL2

2.35e-04307454chr17q25
Cytoband19q13.1

FFAR3 GPR42

1.35e-035545219q13.1
GeneFamilyCytochrome P450 family 11

CYP11B1 CYP11B2

6.93e-0632821007
GeneFamilyC2 domain containing|Calpains

CAPN15 CAPN10

2.40e-0415282975
GeneFamilyFibronectin type III domain containing

ASTN1 EPHA10

2.53e-02160282555
Drugcyadox

CYP11B1 CYP11B2

3.48e-062432ctd:C020728
Drug18-hydroxydeoxycorticosterone

CYP11B1 CYP11B2

3.48e-062432ctd:C042509
DrugDepsipeptides

SREBF1 TIA1 TIAL1

8.15e-0621433ctd:D047630
Drug18-hydroxycortisol

CYP11B1 CYP11B2

1.04e-053432ctd:C033689
DrugC05489

CYP11B1 CYP11B2

2.09e-054432CID000440708
Drug17alpha, 21-dihydroxypregnenolone

CYP11B1 CYP11B2

3.47e-055432CID000192735
DrugXylose

SREBF1 LCT

3.47e-055432ctd:D014994
DrugMethandrostenolone

CYP11B1 CYP11B2

5.20e-056432ctd:D008696
DrugTetrahydronaphthalenes

CYP11B1 CYP11B2

5.20e-056432ctd:D013764
Drugtriheptanoin

LCT MTOR

7.27e-057432CID000069286
DrugCortodoxone

CYP11B1 CYP11B2

7.27e-057432ctd:D003350
DrugAndrostenedione

MTOR CYP11B1 CYP11B2

8.42e-0545433ctd:D000735
Drug2,2',3,3',4,6'-hexachlorobiphenyl

CYP11B1 CYP11B2

9.69e-058432ctd:C094859
Drug2,2',3,4',5',6-hexachlorobiphenyl

CYP11B1 CYP11B2

1.24e-049432ctd:C120129
DrugGKT137831

CYP11B1 CYP11B2

1.24e-049432ctd:C576694
Drugplatycodin D

SREBF1 MTOR

1.24e-049432ctd:C108953
Diseaseadrenal cortical adenoma (is_marker_for)

CYP11B1 CYP11B2

2.27e-062452DOID:0050891 (is_marker_for)
DiseaseMEHMO syndrome (implicated_via_orthology)

EIF2S3B EIF2S3

2.27e-062452DOID:0060801 (implicated_via_orthology)
DiseaseGlucocorticoid-remediable aldosteronism

CYP11B1 CYP11B2

2.27e-062452C1260386
Diseasetype 2 diabetes mellitus (is_implicated_in)

SREBF1 ADRA2B MTOR CYP11B2 CAPN10

6.24e-06171455DOID:9352 (is_implicated_in)
Diseasecongenital adrenal hyperplasia (implicated_via_orthology)

CYP11B1 CYP11B2

6.82e-063452DOID:0050811 (implicated_via_orthology)
Diseaseprimary hyperaldosteronism (is_implicated_in)

CYP11B1 CYP11B2

2.27e-055452DOID:446 (is_implicated_in)
DiseaseHyperaldosteronism

CYP11B1 CYP11B2

3.40e-056452C0020428
Diseasehypopituitarism (implicated_via_orthology)

EIF2S3B EIF2S3

3.40e-056452DOID:9406 (implicated_via_orthology)
DiseaseConn Syndrome

CYP11B1 CYP11B2

3.40e-056452C1384514
Diseasehypertension (implicated_via_orthology)

ADRA2B MTOR CYP11B1 CYP11B2

4.39e-05128454DOID:10763 (implicated_via_orthology)
Diseaseprotocadherin alpha-7 measurement

CYP11B1 CYP11B2

4.75e-057452EFO_0801973
DiseaseIntellectual Disability

MACF1 ASTN1 ADRA2B MTOR EIF2S3 CAPN10

5.77e-05447456C3714756
Diseaseleukodystrophy (implicated_via_orthology)

EIF2S3B EIF2S3

8.13e-059452DOID:10579 (implicated_via_orthology)
Diseaseprotein FAM163B measurement

CYP11B1 CYP11B2

8.13e-059452EFO_0802936
Diseaseandrostenedione measurement

CYP11B1 CYP11B2

1.02e-0410452EFO_0007972
Diseasecell growth regulator with EF hand domain protein 1 measurement

CYP11B1 CYP11B2

1.24e-0411452EFO_0801461
Disease3-hydroxyanthranilate 3,4-dioxygenase measurement

CYP11B1 CYP11B2

1.24e-0411452EFO_0021862
Diseaseaspartate aminotransferase measurement

TMEM150B RASIP1 TIAL1 LCT TVP23A MTOR CYP11B1

4.07e-04904457EFO_0004736
Diseaseapolipoprotein L1 measurement

CYP11B1 CYP11B2

6.67e-0425452EFO_0021854
Diseaseglucose metabolism disease (implicated_via_orthology)

EIF2S3B EIF2S3

8.38e-0428452DOID:4194 (implicated_via_orthology)
Diseasebowel opening frequency

FFAR3 GPR42

9.63e-0430452EFO_0600084
Diseasebrain infarction (biomarker_via_orthology)

CYP11B1 CYP11B2

1.17e-0333452DOID:3454 (biomarker_via_orthology)
Diseasetype 2 diabetes mellitus (biomarker_via_orthology)

SREBF1 MTOR CAPN10

1.47e-03147453DOID:9352 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
GLWRQRLLQSRLVEW

C1orf167

941

Q5SNV9
IQWNQRWGRRPSNRS

CALCR

411

P30988
AIGGQWWRRRAQLTR

ADRA2B

351

P18089
ILLLRIQNPWGRRCW

CAPN10

256

Q9HC96
GWWVRNINTLRRCIE

DMXL2

1636

Q8TDJ6
VRWRQQWLENGTLLF

ASTN1

106

O14525
LLVQELWRARPGWAR

RASIP1

236

Q5U651
ERGLWRSLGQWTIQQ

PARP9

616

Q8IXQ6
RLLRLRNPWGRFSWN

CAPN15

731

O75808
QRLWQRPWLRTAGLG

OGFOD3

36

Q6PK18
VRQARGQRLEWIGWI

IGHV1-58

56

A0A0C4DH39
QQLENIWWQRDGRLL

LLGL2

231

Q6P1M3
WQIQRWWQLGRLRQL

C9orf131

51

Q5VYM1
RVLLQAARGTWWNRP

FDX2

16

Q6P4F2
WRGARLVQSVLRVWQ

ERAL1

6

O75616
ARWQQVWLLALERQR

MACF1

3121

O94854
NRAAPWGTRRLLNWI

LCT

1246

P09848
NWLQTGWISRGRGQR

EPHA10

86

Q5JZY3
LRRLCGLWGQWQQES

GPR42

291

O15529
LQRRQRLQLGRWQGW

MYO15B

396

Q96JP2
LLWQIFGNQGNRWIR

MALRD1

971

Q5VYJ5
QLWQRLWEVQDGRRL

CMPK2

171

Q5EBM0
LRRLCGLWGQWQQES

FFAR3

291

O14843
GNRWLRLLQIWREQG

CYP11B1

46

P15538
SRARRVLQWWQGCRG

CCDC85A

461

Q96PX6
RLQWTWLGRAELQFG

CUL9

1751

Q8IWT3
LEAERRGQQRWIQNW

C2orf50

76

Q96LR7
GNRWLRLLQIWREQG

CYP11B2

46

P19099
WRLIGWGQIRRGVTI

EIF2S3B

451

Q2VIR3
SWNQRARWLRGILLF

PKD1L1

2606

Q8TDX9
RREIIRQIWWERLQG

MTOR

1611

P42345
RQIWWERLQGCQRIV

MTOR

1616

P42345
QLRDWGVRRWPNQLI

TMEM150B

76

A6NC51
RGRLALQWRQVSWIT

LRTM2

11

Q8N967
LQRLWVGRWLAGRAG

SREBF1

636

P36956
QGEENLLAILRRRWW

SLC35F1

116

Q5T1Q4
IGWLVRWKRRNNVGF

TIGD3

121

Q6B0B8
EGLWKWNDRILRLQN

ZNF624

166

Q9P2J8
AGVQTLRWQRWQRRR

TMC8

56

Q8IU68
QLEGWRWNRPGDRIL

TFCP2

136

Q12800
GQTWARRALLLGILW

SLC24A5

6

Q71RS6
LLLQEGSQRRLWRWC

SLAMF9

11

Q96A28
TGRLLVGLRWWNQID

TVP23A

81

A6NH52
QGILRQNEQRWRWIF

TRPM8

886

Q7Z2W7
QWLGGRQIRTNWATR

TIAL1

161

Q01085
NWRQPLQRLLWGLEG

TMEM239

96

Q8WW34
WLGGRQIRTNWATRK

TIA1

171

P31483
WRLIGWGQIRRGVTI

EIF2S3

451

P41091