Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	TLV_coat	ERVV-1 ERVV-2	1.24e-04	7	46	2	PF00429
Domain	TLV/ENV_coat_polyprotein	ERVV-1 ERVV-2	1.65e-04	8	46	2	IPR018154
Domain	CASPASE_HIS	CASP8 CASP9	3.22e-04	11	46	2	PS01121
Domain	Caspase_his_AS	CASP8 CASP9	3.86e-04	12	46	2	IPR016129
Domain	Caspase_cys_AS	CASP8 CASP9	3.86e-04	12	46	2	IPR033139
Domain	CASPASE_P10	CASP8 CASP9	3.86e-04	12	46	2	PS50207
Domain	CASPASE_CYS	CASP8 CASP9	3.86e-04	12	46	2	PS01122
Domain	Pept_C14_p10	CASP8 CASP9	3.86e-04	12	46	2	IPR002138
Domain	CASc	CASP8 CASP9	4.55e-04	13	46	2	SM00115
Domain	Pept_C14A	CASP8 CASP9	4.55e-04	13	46	2	IPR015917
Domain	CASPASE_P20	CASP8 CASP9	5.30e-04	14	46	2	PS50208
Domain	Pept_C14_p20	CASP8 CASP9	5.30e-04	14	46	2	IPR001309
Domain	Caspase-like_dom	CASP8 CASP9	5.30e-04	14	46	2	IPR029030
Domain	-	CASP8 CASP9	5.30e-04	14	46	2	3.40.50.1460
Domain	Kinesin-like_fam	KIF4B KIF15	5.03e-03	43	46	2	IPR027640
Domain	KINESIN_MOTOR_1	KIF4B KIF15	5.26e-03	44	46	2	PS00411
Domain	-	KIF4B KIF15	5.26e-03	44	46	2	3.40.850.10
Domain	Kinesin_motor_dom	KIF4B KIF15	5.26e-03	44	46	2	IPR001752
Domain	Kinesin	KIF4B KIF15	5.26e-03	44	46	2	PF00225
Domain	KISc	KIF4B KIF15	5.26e-03	44	46	2	SM00129
Domain	KINESIN_MOTOR_2	KIF4B KIF15	5.26e-03	44	46	2	PS50067
Domain	HEAT	IPO13 SCYL3	8.99e-03	58	46	2	IPR000357
Domain	HEAT_REPEAT	IPO13 SCYL3	1.29e-02	70	46	2	PS50077
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_TAT_NEF_TO_CROSSTALK_BETWEEN_EXTRINSIC_AND_INTRINSIC_APOPTOTIC_PATHWAYS	CASP8 CASP9	1.39e-04	8	32	2	M47571
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_CROSSTALK_BETWEEN_EXTRINSIC_AND_INTRINSIC_APOPTOTIC_PATHWAYS	CASP8 CASP9	2.71e-04	11	32	2	M47693
Pathway	BIOCARTA_D4GDI_PATHWAY	CASP8 CASP9	3.25e-04	12	32	2	M15513
Pathway	BIOCARTA_D4GDI_PATHWAY	CASP8 CASP9	3.83e-04	13	32	2	MM1380
Pathway	WP_DNA_DAMAGE_RESPONSE	CASP8 CASP9 ATRIP	5.03e-04	69	32	3	M39339
Pathway	KEGG_MEDICUS_REFERENCE_CROSSTALK_BETWEEN_EXTRINSIC_AND_INTRINSIC_APOPTOTIC_PATHWAYS	CASP8 CASP9	5.15e-04	15	32	2	M47448
Pathway	WP_PROSURVIVAL_SIGNALING_OF_NEUROPROTECTIN_D1	CASP8 CASP9	5.15e-04	15	32	2	M45549
Pathway	WP_APOPTOSIS_MODULATION_BY_HSP70	CASP8 CASP9	7.47e-04	18	32	2	MM15964
Pathway	WP_APOPTOSIS_MODULATION_BY_HSP70	CASP8 CASP9	8.33e-04	19	32	2	M39450
Pathway	BIOCARTA_MITOCHONDRIA_PATHWAY	CASP8 CASP9	8.33e-04	19	32	2	M16257
Pathway	SA_CASPASE_CASCADE	CASP8 CASP9	8.33e-04	19	32	2	M7997
Pathway	WP_APOPTOSIS	CASP8 CASP9 HELLS	8.63e-04	83	32	3	MM15972
Pathway	WP_NANOMATERIAL_INDUCED_APOPTOSIS	CASP8 CASP9	9.25e-04	20	32	2	M39479
Pathway	BIOCARTA_MITOCHONDRIA_PATHWAY	CASP8 CASP9	1.02e-03	21	32	2	MM1484
Pathway	WP_APOPTOSIS	CASP8 CASP9 HELLS	1.02e-03	88	32	3	M39654
Pathway	WP_HOSTPATHOGEN_INTERACTION_OF_HUMAN_CORONAVIRUSES_APOPTOSIS	CASP8 CASP9	1.12e-03	22	32	2	M39902
Pathway	BIOCARTA_CASPASE_PATHWAY	CASP8 CASP9	1.12e-03	22	32	2	M17902
Pathway	REACTOME_CASPASE_ACTIVATION_VIA_EXTRINSIC_APOPTOTIC_SIGNALLING_PATHWAY	CASP8 CASP9	1.23e-03	23	32	2	MM15176
Pathway	BIOCARTA_CTCF_PATHWAY	TGFBR3 SMAD5	1.34e-03	24	32	2	M11420
Pathway	BIOCARTA_CTCF_PATHWAY	TGFBR3 SMAD5	1.34e-03	24	32	2	MM1373
Pathway	WP_MIRNA_REGULATION_OF_DNA_DAMAGE_RESPONSE	CASP8 CASP9 ATRIP	1.40e-03	98	32	3	M39524
Pathway	WP_NETWORK_MAP_OF_SARSCOV2_SIGNALING	HRG CASP8 CASP9 SMAD5	1.42e-03	218	32	4	M42569
Pathway	BIOCARTA_CASPASE_PATHWAY	CASP8 CASP9	1.45e-03	25	32	2	MM1359
Pathway	REACTOME_CASPASE_ACTIVATION_VIA_EXTRINSIC_APOPTOTIC_SIGNALLING_PATHWAY	CASP8 CASP9	1.57e-03	26	32	2	M27434
Pathway	REACTOME_TGFBR3_EXPRESSION	TGFBR3 HELLS	1.82e-03	28	32	2	M48253
Pathway	BIOCARTA_DEATH_PATHWAY	CASP8 CASP9	1.95e-03	29	32	2	M14971
Pathway	WP_MIRNA_REGULATION_OF_P53_PATHWAY_IN_PROSTATE_CANCER	CASP8 CASP9	2.23e-03	31	32	2	M39425
Pathway	REACTOME_SIGNALING_BY_BMP	TGFBR3 SMAD5	2.23e-03	31	32	2	M1662
Pathway	REACTOME_SIGNALING_BY_BMP	TGFBR3 SMAD5	2.23e-03	31	32	2	MM14789
Pathway	WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS	CASP8 CASP9	2.37e-03	32	32	2	M39893
Pathway	REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS	LPCAT4 SLC44A5 LIPI	2.49e-03	120	32	3	MM14585
Pathway	REACTOME_NOD1_2_SIGNALING_PATHWAY	CASP8 CASP9	2.52e-03	33	32	2	MM14663
Pathway	BIOCARTA_DEATH_PATHWAY	CASP8 CASP9	2.68e-03	34	32	2	MM1422
Pathway	PID_HIV_NEF_PATHWAY	CASP8 CASP9	2.83e-03	35	32	2	M197
Pathway	REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS	LPCAT4 SLC44A5 LIPI	2.99e-03	128	32	3	M706
Pathway	REACTOME_NOD1_2_SIGNALING_PATHWAY	CASP8 CASP9	3.00e-03	36	32	2	M1059
Pathway	WP_FAS_PATHWAY_AND_STRESS_INDUCTION_OF_HSP_REGULATION	CASP8 CASP9	3.00e-03	36	32	2	MM15967
Pathway	BIOCARTA_ALK_PATHWAY	TGFBR3 SMAD5	3.16e-03	37	32	2	M17400
Pubmed	Influence of caspases 8 and 9 gene promoter polymorphism on prostate cancer susceptibility and early development of hormone refractory prostate cancer.	CASP8 CASP9	1.79e-06	2	47	2	20804486
Pubmed	Caspase 8 and caspase 9 gene polymorphisms and susceptibility to gastric cancer.	CASP8 CASP9	1.79e-06	2	47	2	21461653
Pubmed	Expression and prognostic significance of APAF-1, caspase-8 and caspase-9 in stage II/III colon carcinoma: caspase-8 and caspase-9 is associated with poor prognosis.	CASP8 CASP9	1.79e-06	2	47	2	20013803
Pubmed	BICAO-induced ischaemia caused depressive-like behaviours and caspase-8/-9-dependent brain regional neural cell apoptosis in mice.	CASP8 CASP9	1.79e-06	2	47	2	29600001
Pubmed	Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis.	CASP8 CASP9	1.79e-06	2	47	2	10739648
Pubmed	[Studies on apoptosis and caspase-8 and caspase-9 expressions of bone marrow cells in chronic mountain sickness].	CASP8 CASP9	1.79e-06	2	47	2	22339913
Pubmed	The extrinsic caspase pathway modulates endotoxin-induced diaphragm contractile dysfunction.	CASP8 CASP9	1.79e-06	2	47	2	17218430
Pubmed	Polymorphisms and haplotypes in caspases 8 and 9 genes and risk for prostate cancer: a case-control study in cohort of North India.	CASP8 CASP9	1.79e-06	2	47	2	21396853
Pubmed	Calmodulin Binding Activates Chromobacterium CopC Effector to ADP-Riboxanate Host Apoptotic Caspases.	CASP8 CASP9	1.79e-06	2	47	2	35446120
Pubmed	Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8- and -9-mediated apoptotic pathways in dopaminergic neurons.	CASP8 CASP9	1.79e-06	2	47	2	14993216
Pubmed	The Effect of Caspase 8, 9 Gene Polymorphisms on Non-Hodgkin Lymphoma Susceptibility and Clinical/Pathological Features.	CASP8 CASP9	1.79e-06	2	47	2	36580018
Pubmed	Caspase-8 and caspase-9 mediate thymocyte apoptosis in Trypanosoma cruzi acutely infected mice.	CASP8 CASP9	1.79e-06	2	47	2	23159925
Pubmed	Caspase-8 and Caspase-9 Functioned Differently at Different Stages of the Cyclic Stretch-Induced Apoptosis in Human Periodontal Ligament Cells.	CASP8 CASP9	1.79e-06	2	47	2	27942018
Pubmed	BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells.	CASP8 CASP9	1.79e-06	2	47	2	17030903
Pubmed	The Dietary Flavonoid Fisetin Causes Cell Cycle Arrest, Caspase-Dependent Apoptosis, and Enhanced Cytotoxicity of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells.	CASP8 CASP9	1.79e-06	2	47	2	26755433
Pubmed	[Changes of caspase-8 and caspase-9 activity during apoptosis of keratinocytes induced by trichloroethylene].	CASP8 CASP9	1.79e-06	2	47	2	19493480
Pubmed	Novel caspase-suicide proteins for tamoxifen-inducible apoptosis.	CASP8 CASP9	1.79e-06	2	47	2	18802959
Pubmed	RGDS peptide induces caspase 8 and caspase 9 activation in human endothelial cells.	CASP8 CASP9	1.79e-06	2	47	2	14982875
Pubmed	Caspase 9 and caspase 8 gene polymorphisms and susceptibility to bladder cancer in north Indian population.	CASP8 CASP9	1.79e-06	2	47	2	19412632
Pubmed	Differential evolutionary fate of an ancestral primate endogenous retrovirus envelope gene, the EnvV syncytin, captured for a function in placentation.	ERVV-1 ERVV-2	1.79e-06	2	47	2	23555306
Pubmed	Leptospira interrogans induces apoptosis in macrophages via caspase-8- and caspase-3-dependent pathways.	CASP8 CASP9	1.79e-06	2	47	2	19029301
Pubmed	Artemisinin induces caspase-8/9-mediated and Bax/Bak-independent apoptosis in human lung adenocarcinoma (ASTC-a-1) cells.	CASP8 CASP9	1.79e-06	2	47	2	25214386
Pubmed	Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution.	ERVV-1 ERVV-2	1.79e-06	2	47	2	18826608
Pubmed	Polymorphisms of caspase 8 and caspase 9 gene and colorectal cancer susceptibility and prognosis.	CASP8 CASP9	1.79e-06	2	47	2	21538054
Pubmed	Taurine reduces caspase-8 and caspase-9 expression induced by ischemia in the mouse hypothalamic nuclei.	CASP8 CASP9	1.79e-06	2	47	2	17297564
Pubmed	A unified model for apical caspase activation.	CASP8 CASP9	1.79e-06	2	47	2	12620239
Pubmed	Caspase-8 and Apaf-1-independent caspase-9 activation in Sendai virus-infected cells.	CASP8 CASP9	5.36e-06	3	47	2	12021264
Pubmed	Resveratrol mitigates isoflurane-induced neuroapoptosis by inhibiting the activation of the Akt-regulated mitochondrial apoptotic signaling pathway.	CASP8 CASP9	5.36e-06	3	47	2	23922164
Pubmed	Activation of caspases and apoptosis in response to low-voltage electric pulses.	CASP8 CASP9	5.36e-06	3	47	2	20372860
Pubmed	HIV-1 Vpr: regulator of viral survival.	CASP8 CASP9	5.36e-06	3	47	2	19275584
Pubmed	Safrole oxide induces apoptosis by activating caspase-3, -8, and -9 in A549 human lung cancer cells.	CASP8 CASP9	5.36e-06	3	47	2	16242324
Pubmed	In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells.	CASP8 CASP9	5.36e-06	3	47	2	21724551
Pubmed	Increased caspase activation in peripheral blood mononuclear cells of patients with Alzheimer's disease.	CASP8 CASP9	5.36e-06	3	47	2	15473998
Pubmed	Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury.	CASP8 CASP9	5.36e-06	3	47	2	16497673
Pubmed	Caspases-3, -8, and -9 are required for induction of epithelial cell apoptosis by enteropathogenic E. coli but are dispensable for increased paracellular permeability.	CASP8 CASP9	5.36e-06	3	47	2	18054197
Pubmed	Activation of caspase-9, but not caspase-2 or caspase-8, is essential for heat-induced apoptosis in Jurkat cells.	CASP8 CASP9	5.36e-06	3	47	2	20978129
Pubmed	Expression Level of Caspase Genes in Colorectal Cancer.	CASP8 CASP9	5.36e-06	3	47	2	29801534
Pubmed	Prediagnostic circulating inflammation biomarkers and esophageal squamous cell carcinoma: A case-cohort study in Japan.	CASP8 STAMBP	5.36e-06	3	47	2	31671219
Pubmed	Caspase-8: a key role in the pathogenesis of diabetic embryopathy.	CASP8 CASP9	5.36e-06	3	47	2	19194987
Pubmed	Phosphorylation of murine caspase-9 by the protein kinase casein kinase 2 regulates its cleavage by caspase-8.	CASP8 CASP9	5.36e-06	3	47	2	18467326
Pubmed	Analysis of caspase-3, caspase-8 and caspase-9 enzymatic activities in mouse oocytes and zygotes.	CASP8 CASP9	5.36e-06	3	47	2	15214581
Pubmed	Japanese encephalitis virus infection activates caspase-8 and -9 in a FADD-independent and mitochondrion-dependent manner.	CASP8 CASP9	5.36e-06	3	47	2	18632964
Pubmed	Role of Caspase 8, Caspase 9 and Bcl-2 polymorphisms in papillary thyroid carcinoma risk in Han Chinese population.	CASP8 CASP9	5.36e-06	3	47	2	22120515
Pubmed	ATM kinase promotes both caspase-8 and caspase-9 activation during TNF-α-induced apoptosis of HeLa cells.	CASP8 CASP9	5.36e-06	3	47	2	24530529
Pubmed	ER stress induces caspase-8 activation, stimulating cytochrome c release and caspase-9 activation.	CASP8 CASP9	5.36e-06	3	47	2	12581736
Pubmed	p62/sequestosome-1 up-regulation promotes ABT-263-induced caspase-8 aggregation/activation on the autophagosome.	CASP8 CASP9	5.36e-06	3	47	2	24121507
Pubmed	Human immunodeficiency virus type 1 vpr induces apoptosis through caspase activation.	CASP8 CASP9	1.07e-05	4	47	2	10708425
Pubmed	FoxO3a governs early microglial proliferation and employs mitochondrial depolarization with caspase 3, 8, and 9 cleavage during oxidant induced apoptosis.	CASP8 CASP9	1.07e-05	4	47	2	19807657
Pubmed	In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis.	CASP8 CASP9	1.07e-05	4	47	2	16362053
Pubmed	Roles of p53 and caspases in the induction of cell cycle arrest and apoptosis by HIV-1 vpr.	CASP8 CASP9	1.07e-05	4	47	2	10438581
Pubmed	Apoptosis in the sequestrated nucleus pulposus compared to the remaining nucleus pulposus in the same patient.	CASP8 CASP9	1.07e-05	4	47	2	21178828
Pubmed	PinX1 without the G-patch motif suppresses proliferation, induces senescence, but does not inhibit telomerase activity in colorectal cancer SW480 cells.	CASP8 CASP9	1.07e-05	4	47	2	24839934
Pubmed	Caspase-dependent molecular mechanisms of anti-human DR5 monoclonal antibody mDRA-6 inducing apoptosis of human leukemia Jurkat cells.	CASP8 CASP9	1.07e-05	4	47	2	19550122
Pubmed	Perforin-dependent activation-induced cell death acts through caspase 3 but not through caspases 8 or 9.	CASP8 CASP9	1.07e-05	4	47	2	12616497
Pubmed	Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma.	CASP8 CASP9	1.07e-05	4	47	2	17071630
Pubmed	Cleavage of phospholipase D1 by caspase promotes apoptosis via modulation of the p53-dependent cell death pathway.	CASP8 CASP9	1.07e-05	4	47	2	18636075
Pubmed	Structure and function of HIV-1 auxiliary regulatory protein Vpr: novel clues to drug design.	CASP8 CASP9	1.07e-05	4	47	2	15578977
Pubmed	Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease.	CASP8 CASP9	1.07e-05	4	47	2	11739563
Pubmed	Caspase polymorphisms and genetic susceptibility to multiple myeloma.	CASP8 CASP9	1.07e-05	4	47	2	18381704
Pubmed	HIV-1 Vpr induces apoptosis through caspase 9 in T cells and peripheral blood mononuclear cells.	CASP8 CASP9	1.07e-05	4	47	2	12095993
Pubmed	Adenovirus encoding HIV-1 Vpr activates caspase 9 and induces apoptotic cell death in both p53 positive and negative human tumor cell lines.	CASP8 CASP9	1.07e-05	4	47	2	12096338
Pubmed	Green tea (-)-epigalocatechin-3-gallate inhibits KIT activity and causes caspase-dependent cell death in gastrointestinal stromal tumor including imatinib-resistant cells.	CASP8 CASP9	1.07e-05	4	47	2	19770581
Pubmed	[Soluble apoptosis markers in obese patients with food intolerance].	CASP8 CASP9	1.07e-05	4	47	2	25059065
Pubmed	Synergistic effects of valproic acid and arsenic trioxide on RPMI8226 cells in vitro and the possible underlying mechanisms.	CASP8 CASP9	1.07e-05	4	47	2	25815518
Pubmed	Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway.	CASP8 CASP9	1.78e-05	5	47	2	19325570
Pubmed	Integrin-linked kinase interacts with caspase-9 and -8 in an adhesion-dependent manner for promoting radiation-induced apoptosis in human leukemia cells.	CASP8 CASP9	1.78e-05	5	47	2	16936772
Pubmed	Thymoquinone inhibits growth of human medulloblastoma cells by inducing oxidative stress and caspase-dependent apoptosis while suppressing NF-κB signaling and IL-8 expression.	CASP8 CASP9	1.78e-05	5	47	2	27084536
Pubmed	Ginsenoside Rh2 induces human hepatoma cell apoptosisvia bax/bak triggered cytochrome C release and caspase-9/caspase-8 activation.	CASP8 CASP9	1.78e-05	5	47	2	23443079
Pubmed	Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.	NEK1 ATRIP	1.78e-05	5	47	2	23345434
Pubmed	Copper induced apoptosis in Caco-2 and Hep-G2 cells: Expression of caspases 3, 8 and 9, AIF and p53.	CASP8 CASP9	1.78e-05	5	47	2	27046389
Pubmed	c-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells.	CASP8 CASP9	1.78e-05	5	47	2	18840411
Pubmed	Polymorphisms in the CASPASE genes and survival in patients with early-stage non-small-cell lung cancer.	CASP8 CASP9	1.78e-05	5	47	2	19826114
Pubmed	CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.	CASP8 CASP9	1.78e-05	5	47	2	7983002
Pubmed	Engineered hybrid dimers: tracking the activation pathway of caspase-7.	CASP8 CASP9	1.78e-05	5	47	2	16916640
Pubmed	Silver nanoparticles biosynthesized using Achillea biebersteinii flower extract: apoptosis induction in MCF-7 cells via caspase activation and regulation of Bax and Bcl-2 gene expression.	CASP8 CASP9	1.78e-05	5	47	2	25665064
Pubmed	Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway.	CASP8 CASP9	1.78e-05	5	47	2	21980415
Pubmed	Ethyl gallate induces apoptosis of HL-60 cells by promoting the expression of caspases-8, -9, -3, apoptosis-inducing factor and endonuclease G.	CASP8 CASP9	1.78e-05	5	47	2	23109891
Pubmed	Molecular cloning and characterization of mouse caspase-8.	CASP8 CASP9	1.78e-05	5	47	2	9654089
Pubmed	Prostaglandin E(2) induces fibroblast apoptosis by modulating multiple survival pathways.	CASP8 CASP9	1.78e-05	5	47	2	19671668
Pubmed	Sustained inhibition of tumor growth and prolonged survival following sequential administration of doxorubicin and zoledronic acid in a breast cancer model.	CASP8 CASP9	1.78e-05	5	47	2	19621384
Pubmed	Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation.	CASP8 CASP9	1.78e-05	5	47	2	9539746
Pubmed	Virion-associated Vpr of human immunodeficiency virus type 1 triggers activation of apoptotic events and enhances fas-induced apoptosis in human T cells.	CASP8 CASP9	1.78e-05	5	47	2	19692467
Pubmed	Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis.	CASP8 CASP9	2.67e-05	6	47	2	11423904
Pubmed	Altered apoptosis of inflammatory neutrophils in MMP-9-deficient mice is due to lower expression and activity of caspase-3.	CASP8 CASP9	2.67e-05	6	47	2	19682497
Pubmed	Identification of a caspase-9 substrate and detection of its cleavage in programmed cell death during mouse development.	CASP8 CASP9	2.67e-05	6	47	2	11514563
Pubmed	Caspase knockouts: matters of life and death.	CASP8 CASP9	2.67e-05	6	47	2	10578172
Pubmed	Activation of Pro-apoptotic Caspases in Non-apoptotic Cells During Odontogenesis and Related Osteogenesis.	CASP8 CASP9	2.67e-05	6	47	2	29563882
Pubmed	Serum response factor cleavage by caspases 3 and 7 linked to apoptosis in human BJAB cells.	CASP8 CASP9	2.67e-05	6	47	2	11387340
Pubmed	Reduction of caspase-8 and -9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic injury in mice overexpressing Hsp70.	CASP8 CASP9	2.67e-05	6	47	2	16397188
Pubmed	Changes in nuclear morphology during apoptosis correlate with vimentin cleavage by different caspases located either upstream or downstream of Bcl-2 action.	CASP8 CASP9	2.67e-05	6	47	2	10469173
Pubmed	The Siva protein is a novel intracellular ligand of the CD4 receptor that promotes HIV-1 envelope-induced apoptosis in T-lymphoid cells.	CASP8 CASP9	2.67e-05	6	47	2	17653867
Pubmed	The mechanism of neogambogic acid-induced apoptosis in human MCF-7 cells.	CASP8 CASP9	2.67e-05	6	47	2	21785112
Pubmed	Polymorphisms in the caspase genes and the risk of lung cancer.	CASP8 CASP9	2.67e-05	6	47	2	20661084
Pubmed	Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: Emergence of new molecular targets.	ERVV-1 ERVV-2	2.67e-05	6	47	2	23085571
Pubmed	Caspase-14, a keratinocyte specific caspase: mRNA splice variants and expression pattern in embryonic and adult mouse.	CASP8 CASP9	3.74e-05	7	47	2	11526440
Pubmed	Peroxiredoxin 6 interferes with TRAIL-induced death-inducing signaling complex formation by binding to death effector domain caspase.	CASP8 CASP9	3.74e-05	7	47	2	20829884
Pubmed	Apoptotic gene analysis in idiopathic talipes equinovarus (clubfoot).	CASP8 CASP9	3.74e-05	7	47	2	17534194
Pubmed	Bortezomib induces apoptosis of Epstein-Barr virus (EBV)-transformed B cells and prolongs survival of mice inoculated with EBV-transformed B cells.	CASP8 CASP9	3.74e-05	7	47	2	17626072
Pubmed	Roles of caspases in apoptosis, development, and cytokine maturation revealed by homozygous gene deficiencies.	CASP8 CASP9	3.74e-05	7	47	2	10671365
Pubmed	Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB.	CASP8 CASP9	4.98e-05	8	47	2	10329646
Cytoband	4q22.1	TIGD2 HSD17B11	3.42e-04	26	48	2	4q22.1
GeneFamily	Caspases\|Caspase recruitment domain containing	CASP8 CASP9	2.49e-04	13	33	2	468
GeneFamily	DNA helicases	PIF1 HELLS	4.32e-04	17	33	2	1167
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF4B KIF15	3.18e-03	46	33	2	622
Coexpression	GSE4984_UNTREATED_VS_VEHICLE_CTRL_TREATED_DC_DN	DARS1 SNUPN TRMT5 NUMBL NAA16	1.49e-05	174	47	5	M6501
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KIF4B KIF15 PIF1 MYBL1 HELLS	9.98e-07	167	48	5	50c29ea660bf07b890e4ac1a1985d0761d863dee
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4-5_RORB_ASCL1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF462 TGFBR3 VIPR2 SCRG1 SLC44A5	1.19e-06	173	48	5	2e35bf2b5534a289d93a09faae660f665c131062
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF15 TRMT5 PIF1 MYBL1 HELLS	1.22e-06	174	48	5	72df66319f6efbd88ecf439013d97409fbf3cb52
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF15 TRMT5 PIF1 MYBL1 HELLS	1.22e-06	174	48	5	c6087fd0e036ec7f40f0f8f17d1f6ce13ddb5235
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma-3\|TCGA-Brain / Sample_Type by Project: Shred V9	VIPR2 CASP9 TIGD2 TRMT5	1.36e-05	135	48	4	b128596653a5e3b64ed7f657bbfeda35438e2e48
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TGFBR3 PLD5 TIGD2 MYBL1	2.92e-05	164	48	4	ed7277f8980f96f5b3e4eed025d46d0942e123d7
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TGFBR3 PLD5 TIGD2 MYBL1	2.92e-05	164	48	4	c4ad98106e8663caf7c1c15d30ec633d8bd8cf57
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIF4B KIF15 PIF1 MYBL1	2.99e-05	165	48	4	eec2d327c94832d1390314c93ef6a2be4648478b
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KIF4B KIF15 MYBL1 HELLS	3.06e-05	166	48	4	2642544070564debe2deb2938d2c33997bf5ef02
ToppCell	PND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PRDM10 KIF15 PIF1 MYBL1	3.14e-05	167	48	4	754e6412d3b9cc0b126e59593df2f5956b4712ef
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KIF4B KIF15 PIF1 MYBL1	3.21e-05	168	48	4	d35944fd9fea9934ce1e76b2b35d48e2300cca61
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-FOXM1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KIF15 PIF1 MYBL1 HELLS	3.29e-05	169	48	4	e0607af8ae8609d43e26ff2a2cab92650bfcd5b7
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KIF15 PIF1 MYBL1 HELLS	4.20e-05	180	48	4	401df9cddcbca1eb8f0d2687bcacd98e95dc1493
ToppCell	Control-T/NK-proliferating_T/NK\|Control / Disease group,lineage and cell class （2021.01.30）	ZNF462 KIF15 PIF1 HELLS	4.48e-05	183	48	4	e740f05536d1e4b2512811771928eb65f6696409
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CACNG5\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF462 TGFBR3 VIPR2 PLD5	4.58e-05	184	48	4	658f2e522055e88c92bc482a845c40f8f5f1a8e3
ToppCell	Control-T_cells-Cycling_NK/T_cells\|Control / group, cell type (main and fine annotations)	KIF15 PIF1 MYBL1 HELLS	4.67e-05	185	48	4	9766216b41ee62bbac4caa25cb98ec5627a24075
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KIF15 PIF1 MYBL1 HELLS	4.67e-05	185	48	4	30e041d6f6e310d64809e9d6d93cd30052972f3b
ToppCell	URO-Lymphocyte-T_NK-T_NK_proliferative\|URO / Disease, Lineage and Cell Type	KIF4B KIF15 PIF1 HELLS	4.67e-05	185	48	4	0ae9c646679c69a553eda670aef0e0495feb0286
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF462 TGFBR3 SCYL3 MYBL1	4.87e-05	187	48	4	b426a67b5669019115b58295ce7d304beeb75825
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KIF15 PIF1 MYBL1 HELLS	4.87e-05	187	48	4	9351fa87b69a951af85b10bf91fe9b1cce8c0517
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KIF15 PIF1 MYBL1 HELLS	4.87e-05	187	48	4	057569c9437219ecc396aa6e673b1178a2273837
ToppCell	Control-Endothelial-Endothelial-FOXM1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KIF15 PIF1 MYBL1 HELLS	5.08e-05	189	48	4	1e1499b062d9c647c8f38b0c4e0d871d159be5dd
ToppCell	normal_Pleural_Fluid-T/NK_cells-Undetermined\|normal_Pleural_Fluid / Location, Cell class and cell subclass	KIF4B KIF15 PIF1 HELLS	5.18e-05	190	48	4	165c61443ff0c8efbdad3b052bb00f46d81c5203
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF462 TGFBR3 SCYL3 MYBL1	5.18e-05	190	48	4	600b9674197f743dea1d19d3df0fc993b6e6aa25
ToppCell	LV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	TGFBR3 SPATA6 HSD17B11 VEGFD	5.29e-05	191	48	4	d36565257ccba8c1bbed2c1c01be66a9cbb5f834
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_ILC-NK_cell\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF462 TGFBR3 SCYL3 MYBL1	5.40e-05	192	48	4	c5f77c2103841505d13e09173549811312ef2f01
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_ILC\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF462 TGFBR3 SCYL3 MYBL1	5.40e-05	192	48	4	e981162f387a31111c0ae8355dbe9db5785c4838
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CASP8 MED23 MYBL1 HELLS	5.97e-05	197	48	4	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	mild-low-quality_cells\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TGFBR3 CASP8 VIPR2 MYBL1	5.97e-05	197	48	4	e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCell	distal-Hematologic-Proliferating_NK/T-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KIF4B KIF15 PIF1 HELLS	5.97e-05	197	48	4	04b10879e48c101d1de449db0bc6b6484090b965
ToppCell	cycling_basal_cell\|World / shred by cell class for bronchial biopsy	KIF4B KIF15 TRMT5 PIF1	6.08e-05	198	48	4	d5306121a75c5eb37d62c353799a98e6ba5ab63f
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Proliferating-cycling_ventral_progenitors\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	SCRG1 KIF15 MYBL1 HELLS	6.20e-05	199	48	4	446cd7d960812519fe2b8e434578ef0b668c75ce
ToppCell	(2)_B_cell-(24)_B_cell_cycling\|(2)_B_cell / shred on Cell_type and subtype	HAPLN4 KIF15 MYBL1 HELLS	6.20e-05	199	48	4	d5a9a8a71c4de8cbcef947943f60838731bc640b
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon-Proliferating-Cycling_Progenitors\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	KIF15 PIF1 MYBL1 HELLS	6.20e-05	199	48	4	a99516a5760f49a69b0fe45a9b2316e393252966
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Proliferating-Cycling_IN_Progenitors\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	KIF15 PIF1 MYBL1 HELLS	6.20e-05	199	48	4	f315ec3fb6c0799668c9195f836a77fc0db2b615
ToppCell	LPS_IL1RA-Endothelial-Endothelial-FOXM1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	KIF15 PIF1 MYBL1 HELLS	6.20e-05	199	48	4	be2276c9a1994579ba1d2998b49bf549c1324d44
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-FOXM1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	KIF15 PIF1 MYBL1 HELLS	6.33e-05	200	48	4	4cfe08878a6981bf7b3567f9e82192d8f060ddde
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Proliferating\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	KIF15 PIF1 MYBL1 HELLS	6.33e-05	200	48	4	cea58274efbe7f9e3c3ef9fbb768ebfb917e21d9
ToppCell	Control_saline-Endothelial-Endothelial-FOXM1\|Control_saline / Treatment groups by lineage, cell group, cell type	KIF15 PIF1 MYBL1 HELLS	6.33e-05	200	48	4	9bbc7b5561151f6ff65f40b3226271def732e5d9
ToppCell	Sigmoid-(1)_T_cell-(18)_cycling_gd_T\|Sigmoid / shred on region, Cell_type, and subtype	TIGD2 KIF15 NUMBL VNN2	6.33e-05	200	48	4	6e367abd1a4b87e20eb9095b8337723163e8bbae
ToppCell	Sigmoid-T_cell-cycling_gd_T\|T_cell / Region, Cell class and subclass	TIGD2 KIF15 NUMBL VNN2	6.33e-05	200	48	4	4e489ecf472857357d45e9f6c7a812aa48b72ebf
ToppCell	Sigmoid-T_cell-cycling_gd_T\|Sigmoid / Region, Cell class and subclass	TIGD2 KIF15 NUMBL VNN2	6.33e-05	200	48	4	9769185abae084ffac36420c749625e679b70ca8
ToppCell	droplet-Lung-18m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l14\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IPO13 DARS1 MED23	2.65e-04	116	48	3	f2bf9599040f43b5ea8724841d7b71c0a859c016
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c05-FOS\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF597 ZNF462 PRDM10	3.62e-04	129	48	3	2f30b4897343586c9b49a1d2bec3007ec737085c
ToppCell	COVID-19_Severe-Classical_Monocyte-\|Classical_Monocyte / Disease condition and Cell class	TGFBR3 PLD5 MYBL1	4.23e-04	136	48	3	e272d11bb52f890f6681cc9384aeac27976ec650
ToppCell	COVID-19_Severe-Classical_Monocyte-\|COVID-19_Severe / Disease condition and Cell class	TGFBR3 PLD5 MYBL1	4.60e-04	140	48	3	cade44740dd3acca7789591aa5a7935d48d5cbee
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF462 PRDM10 TIGD2	4.90e-04	143	48	3	d0ed8c25da1327085e042c2e03cb7503e2c52ce0
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-plasmacytoid_dendritic_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF462 PRDM10 TIGD2	4.90e-04	143	48	3	8900b92a24289204b9ec7baccc11594fec7694f1
ToppCell	Dividing_Macrophages-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	HAPLN4 KIF4B KIF15	5.41e-04	148	48	3	66b51aa6690bf8fbc90fa5a6f86191703e2d5046
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	TGFBR3 VIPR2 MYBL1	5.74e-04	151	48	3	def98dc2a8226295b62de2b7f1b587e03a4f038c
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TGFBR3 CASP8 MYBL1	5.96e-04	153	48	3	d8773ee16c7d3e0834b9f64054d42336d6f9833b
ToppCell	PND03-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HK1 NUMBL MYBL1	5.96e-04	153	48	3	489228ab81c3ae339a53a9da6c2a1c1b6ac3f84b
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TGFBR3 VIPR2 PRDM10	6.67e-04	159	48	3	57df5c9b678a15eb5e025e1a80de2e6769cc13d5
ToppCell	droplet-Thymus-nan-21m-Myeloid-Macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCRG1 GARNL3 VEGFD	6.91e-04	161	48	3	441ebd3c029861d833fbcf8a68fc740d9de8ef2f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIF4B KIF15 MYBL1	7.16e-04	163	48	3	3f434015c0cbefb31eeda133c34f75384c5f7e22
ToppCell	droplet-Mammary_Gland-nan-21m-Epithelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEK1 SNUPN GARNL3	7.42e-04	165	48	3	7c771f22b58989572c939ed127e637ec28dc0dca
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIF15 MYBL1 HELLS	7.42e-04	165	48	3	88681101d7cf60b99b8ace5d8c0944323b937306
ToppCell	TCGA-Colorectal-Solid_Tissue_Normal-Colon_normal_tissue-Colon_normal_tissue-9\|TCGA-Colorectal / Sample_Type by Project: Shred V9	VIPR2 SCRG1 VEGFD	7.55e-04	166	48	3	68e6fc7c0040bbe48a93f96ecf28afffdc626845
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KIF15 MYBL1 HELLS	7.68e-04	167	48	3	108ae6221c6edc63c0ec42c42471b3a15a594043
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	NEK1 GTPBP8 STAMBP	7.82e-04	168	48	3	ca94b29c1030484143a77f2df06dad74d2c6136e
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GARNL3 MYBL1 HELLS	7.82e-04	168	48	3	08f6e171a1ea5cf65149744296d0fcd6c7b9684e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KIF15 MYBL1 HELLS	7.95e-04	169	48	3	0bc8ef341ce307b19018d4ac8de0a4d04254209d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KIF15 MYBL1 HELLS	7.95e-04	169	48	3	e7514956b2e4298222ec443f98b2f5289451786e
ToppCell	COVID-19_Severe-CD4+_CTL\|World / disease group, cell group and cell class	HAPLN4 TGFBR3 MYBL1	7.95e-04	169	48	3	8c8168ac93a808d7b4756e4491db2b2979df1c1f
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VIPR2 KIF15 PIF1	8.09e-04	170	48	3	a7184dc41f90caa753860ed0f65a18133f84bc5f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KIF15 PIF1 MYBL1	8.09e-04	170	48	3	21bfe070e63722672176052b386167ea4c3dc4e5
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KIF15 PIF1 MYBL1	8.23e-04	171	48	3	c2dbc439af28d4fabb24d57685b75b2e588819b0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SCRG1 KIF15 HELLS	8.23e-04	171	48	3	b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SCRG1 KIF15 HELLS	8.23e-04	171	48	3	b0373ed8283ee1792b6a490bff93906546978593
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF15 MYBL1 HELLS	8.37e-04	172	48	3	2b6cd84c946b1e800caba452ae70145ea285fec1
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(15)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	KIF15 HSD17B11 PIF1	8.37e-04	172	48	3	7f3d0ef18f5df1ed80498d435b0378ca398c0b88
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIF15 MYBL1 HELLS	8.51e-04	173	48	3	a25459b8140b0dbcb73e3b4cc1407b679229f25c
ToppCell	droplet-Lung-nan-21m-Myeloid-Proliferating_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF15 PIF1 HELLS	8.51e-04	173	48	3	2eb6e9fc3a3654f6f86fbd112e80a18814afd103
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-B_cells-Cycling_B_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VNN2 MYBL1 HELLS	8.51e-04	173	48	3	b7e0193fd4983cb38d1bee441f608f73ee8743b9
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KIF15 MYBL1 HELLS	8.65e-04	174	48	3	84da9faff088d05233183b425385beb054c92d1b
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	VIPR2 SLC44A5 VEGFD	8.65e-04	174	48	3	9c916af5eebd932f67dc9117e1d26ff194a2ff2c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	VIPR2 SLC44A5 VEGFD	8.65e-04	174	48	3	bc71521f44a5fe013af42b06b5d1bd2446ecf3b5
ToppCell	P15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TGFBR3 VIPR2 VEGFD	8.65e-04	174	48	3	3c47d069bd836599a8d40eae485c23d4d3487517
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIF15 PIF1 MYBL1	8.65e-04	174	48	3	7b318796728001c17b4043d2b033330c7be40c78
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIF15 PIF1 MYBL1	8.65e-04	174	48	3	c26eac176e9b0cba385630fdc60e0314a4e4caac
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KIF15 PIF1 MYBL1	8.65e-04	174	48	3	dbb4e1a6c3319ce40f81bfd2d1745a88a2cc412e
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF15 PIF1 HELLS	8.65e-04	174	48	3	7b2f35add804981c7d588a996bdbca6ec11a1ca5
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PRDM10 KIF15 MYBL1	8.80e-04	175	48	3	15c69dd5635c9251c535f1e22467712e9667ae92
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	TGFBR3 KIF15 MYBL1	8.80e-04	175	48	3	63e977b8bafae1c5f742fc35a4cc712fefa9727f
ToppCell	droplet-Lung-21m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KIF15 PIF1 HELLS	8.80e-04	175	48	3	73f25bd54309aed1480ddc44bdab518b17e71f92
ToppCell	PND10-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PRDM10 KIF15 NUMBL	8.94e-04	176	48	3	90f8bb11f339f67f08692a0c33dd420f5cda2861
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PLD5 KIF15 MYBL1	8.94e-04	176	48	3	45c6983ab671b0f306e7390320bd84f848e474cc
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VIPR2 VEGFD HELLS	8.94e-04	176	48	3	d30241fb8119834d6e7b59efec3f92fc7a3d1247
ToppCell	COVID-19_Severe-CD4+_CTL\|COVID-19_Severe / disease group, cell group and cell class	HAPLN4 TGFBR3 MYBL1	9.09e-04	177	48	3	34e9455790bae905dd91923792f4109d18b7686e
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(15)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	KIF15 HSD17B11 PIF1	9.39e-04	179	48	3	6718cadcc2d3b64717ed84244ef1242d392662dc
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	VIPR2 SCRG1 SLC44A5	9.39e-04	179	48	3	8766a5a066091879f521acfc612abf563ff78808
ToppCell	droplet-Spleen-nan-3m-Lymphocytic-immature_NKT_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF15 PIF1 HELLS	9.39e-04	179	48	3	54621d2b3a66e62aa76b7e444118878ed97c1e02
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KIF15 MYBL1 HELLS	9.39e-04	179	48	3	88d44b04eb5c079531db663ed98ddb20b60feb9a
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KIF15 MYBL1 HELLS	9.39e-04	179	48	3	80112c686a8f85ad5e3cda6e3f3d3d51cf688092
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF15 PIF1 MYBL1	9.39e-04	179	48	3	4166c4e1a8748a79ac6a11fd0b97c5344be2321b
ToppCell	ASK454-Epithelial-Ciliated\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	IPO13 NEK1 SPATA6	9.39e-04	179	48	3	f21919ef9d3d984e2925ef3d24f89e20fe265dcd
ToppCell	ASK440-Immune-NK_cell\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	CASP8 VNN2 MYBL1	9.54e-04	180	48	3	340e750356d23fe9af0e8f298f8a273ff426052f
ToppCell	LPS-IL1RA-Endothelial-Endothelial-FOXM1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KIF15 PIF1 MYBL1	9.54e-04	180	48	3	334e2b1f6eb7d4ece20b1c7b02107863f913237f
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KIF15 MYBL1 HELLS	9.54e-04	180	48	3	f8a15c13d85c1bbbf86ce49bb6f86c368ddf22df
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(15)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	KIF15 HSD17B11 PIF1	9.54e-04	180	48	3	ed4966765a6b25456f68185cf0648c4a3a21d7fe
Drug	selenadiazole	CASP8 CASP9	3.65e-06	2	44	2	CID000141276
Drug	caseargrewiin F	CASP8 CASP9	3.65e-06	2	44	2	ctd:C546626
Drug	1-(acetyloxy)-3,5,6,6a,7,8,9,10-octahydro-10-hydroxy-7,8-dimethyl-7-(3-methylpenta-2,4-dien-1-yl)naphtho(1,8a-c)furan-3,5-diyl dibutanoate	CASP8 CASP9	3.65e-06	2	44	2	ctd:C548433
Drug	lonidamine	CASP8 CASP9 HK1	6.39e-06	19	44	3	ctd:C016371
Drug	plumbagin	CASP8 CASP9 HK1	1.01e-05	22	44	3	ctd:C014758
Drug	azadiradione	CASP8 CASP9	1.09e-05	3	44	2	ctd:C479321
Drug	2-amino-3-hydroxy-2-hydroxymethylpropyl 3-acetylbetulinoate	CASP8 CASP9	1.09e-05	3	44	2	ctd:C000599178
Drug	4-methylethcathinone	CASP8 CASP9	1.09e-05	3	44	2	ctd:C585202
Drug	28-deoxonimbolide	CASP8 CASP9	1.09e-05	3	44	2	ctd:C062897
Drug	3,4-methylenedioxypyrovalerone	CASP8 CASP9	1.09e-05	3	44	2	ctd:C554666
Drug	pentedrone	CASP8 CASP9	1.09e-05	3	44	2	ctd:C572410
Drug	1,1,4-tris(acetyloxy)-2-nonene	CASP8 CASP9	2.18e-05	4	44	2	ctd:C449673
Drug	G226 compound	CASP8 CASP9	2.18e-05	4	44	2	ctd:C000600490
Drug	neoxanthin	CASP8 CASP9	2.18e-05	4	44	2	ctd:C011947
Drug	WP 631	CASP8 CASP9	2.18e-05	4	44	2	ctd:C104426
Drug	Npf-4,9-dione	CASP8 CASP9	2.18e-05	4	44	2	CID000079740
Drug	AC1NST5P	CASP8 CASP9	2.18e-05	4	44	2	CID005315533
Drug	acetyl-isoleucyl-glutamyl-threonyl-aspartyl-aldehyde	CASP8 CASP9	2.18e-05	4	44	2	ctd:C401206
Drug	alexidine	CASP8 CASP9	2.18e-05	4	44	2	CID000002090
Drug	AC1L7WDF	CASP8 CASP9	2.18e-05	4	44	2	CID000317613
Drug	Rhododactynaphin-jc-1	CASP8 CASP9	3.64e-05	5	44	2	CID000623379
Drug	ascididemin	CASP8 CASP9	3.64e-05	5	44	2	CID000189219
Drug	NSC93134	CASP8 CASP9	3.64e-05	5	44	2	CID000417553
Drug	1,2,3,4,6,7-hexachlorinated naphthalene	CASP8 CASP9	3.64e-05	5	44	2	ctd:C412791
Drug	CFM 1	CASP8 CASP9	3.64e-05	5	44	2	ctd:C119032
Drug	1,4-anthraquinone	CASP8 CASP9	3.64e-05	5	44	2	ctd:C416442
Drug	dihydrochelerythrine	CASP8 CASP9	3.64e-05	5	44	2	CID000485077
Drug	6(hydroxymethyl)-1,4-anthracenedione	CASP8 CASP9	3.64e-05	5	44	2	ctd:C530630
Drug	Caspase Inhibitors	CASP8 CASP9	5.45e-05	6	44	2	ctd:D061945
Drug	AC1L4NYW	CASP8 CASP9	5.45e-05	6	44	2	CID000189051
Drug	Morphol	CASP8 CASP9	5.45e-05	6	44	2	CID000102256
Drug	allocryptopine	CASP8 CASP9	5.45e-05	6	44	2	CID000098570
Drug	grifolin	CASP8 CASP9	5.45e-05	6	44	2	ctd:C058858
Drug	methylone	CASP8 CASP9	5.45e-05	6	44	2	ctd:C400939
Drug	XCT790	CASP8 CASP9	5.45e-05	6	44	2	ctd:C488234
Drug	2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester	CASP8 CASP9	5.45e-05	6	44	2	ctd:C433771
Drug	phthalocyanine Pc 4	CASP8 CASP9	5.45e-05	6	44	2	ctd:C107448
Drug	thiosulfinic acids	CASP8 CASP9	5.45e-05	6	44	2	ctd:C100040
Drug	alborixin	CASP8 CASP9	5.45e-05	6	44	2	ctd:C012708
Drug	gardenin B	CASP8 CASP9	5.45e-05	6	44	2	ctd:C000591222
Drug	furanodiene	CASP8 CASP9	5.45e-05	6	44	2	CID000636458
Drug	acetyl-leucyl-glutamyl-histidyl-aspartal	CASP8 CASP9	5.45e-05	6	44	2	ctd:C420218
Drug	2-5,6,7,8,4'-pentamethoxyflavanone	CASP8 CASP9	7.62e-05	7	44	2	ctd:C544133
Drug	merocil	CASP8 CASP9	7.62e-05	7	44	2	CID000134013
Drug	cinobufotalin	CASP8 CASP9	7.62e-05	7	44	2	ctd:C063451
Drug	neem oil	CASP8 CASP9	7.62e-05	7	44	2	ctd:C002443
Drug	6-(N,N-dimethylamino)-2-(naphthalene-1-yl)-4-quinazolinone	CASP8 CASP9	7.62e-05	7	44	2	ctd:C583883
Drug	methyl 5-chloro-4,5-didehydrojasmonate	CASP8 CASP9	7.62e-05	7	44	2	ctd:C555027
Drug	clavulone II	CASP8 CASP9	7.62e-05	7	44	2	ctd:C057741
Drug	erucylphospho-N,N,N-trimethylpropylammonium	CASP8 CASP9	7.62e-05	7	44	2	ctd:C472787
Drug	sesamol	CASP8 CASP9	7.62e-05	7	44	2	ctd:C025583
Drug	hydroperoxyisophosphamide	CASP8 CASP9	7.62e-05	7	44	2	ctd:C012353
Drug	Pinacidil	CASP8 CASP9	7.62e-05	7	44	2	ctd:D020110
Drug	demethoxyfumitremorgin C	CASP8 CASP9	1.01e-04	8	44	2	ctd:C100698
Drug	ethyl benzoate	CASP8 CASP9	1.01e-04	8	44	2	CID000007165
Drug	salicylaldehyde isonicotinoyl hydrazone	CASP8 CASP9	1.01e-04	8	44	2	ctd:C413684
Drug	4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine	CASP8 CASP9	1.01e-04	8	44	2	ctd:C475622
Drug	quinoline-val-asp(OMe)-CH2-OPH	CASP8 CASP9	1.01e-04	8	44	2	ctd:C468548
Drug	Sesquiterpenes	CASP8 CASP9	1.01e-04	8	44	2	ctd:D012717
Drug	codonoposide	CASP8 CASP9	1.01e-04	8	44	2	ctd:C463759
Drug	nitrosocarbofuran	CASP8 CASP9	1.01e-04	8	44	2	CID000044098
Drug	paederosidic acid	CASP8 CASP9	1.01e-04	8	44	2	ctd:C000588809
Drug	caraway oil	CASP8 CASP9	1.01e-04	8	44	2	ctd:C104525
Drug	Molybdenum	CASP8 CASP9	1.01e-04	8	44	2	ctd:D008982
Drug	narciclasine	CASP8 CASP9	1.01e-04	8	44	2	CID000072376
Drug	EDBA	CASP8 CASP9	1.01e-04	8	44	2	CID000164632
Drug	Trypsin Inhibitors	CASP8 CASP9	1.01e-04	8	44	2	ctd:D014361
Drug	Trifluridine	CASP8 CASP9	1.01e-04	8	44	2	ctd:D014271
Drug	benzoylurea	CASP8 CASP9	1.01e-04	8	44	2	CID000069190
Drug	suillin	CASP8 CASP9	1.01e-04	8	44	2	ctd:C061636
Drug	Isatin analog 2	CASP8 CASP9	1.01e-04	8	44	2	CID010826725
Drug	Isatin Sulfonamide 29	CASP8 CASP9	1.30e-04	9	44	2	CID009821545
Drug	yomogin	CASP8 CASP9	1.30e-04	9	44	2	CID000174865
Drug	Dexmedetomidine	CASP8 CASP9	1.30e-04	9	44	2	ctd:D020927
Drug	CA 074 methyl ester	CASP8 CASP9	1.30e-04	9	44	2	ctd:C400541
Drug	echinocystic acid	CASP8 CASP9	1.30e-04	9	44	2	ctd:C022999
Drug	FLLL 32	CASP8 CASP9	1.30e-04	9	44	2	ctd:C548902
Drug	Caseamembrins O	CASP8 CASP9	1.30e-04	9	44	2	CID006326337
Drug	cagA protein, Helicobacter pylori	CASP8 CASP9	1.30e-04	9	44	2	ctd:C080866
Drug	N,N-dimethylphytosphingosine	CASP8 CASP9	1.30e-04	9	44	2	ctd:C542681
Drug	Styrene	TGFBR3 CASP8 CASP9	1.56e-04	54	44	3	ctd:D020058
Drug	gentiopicroside	CASP8 CASP9	1.63e-04	10	44	2	ctd:C012997
Drug	JAI-51	CASP8 CASP9	1.63e-04	10	44	2	ctd:C545474
Drug	iotrolan	DARS1 HK1	1.63e-04	10	44	2	CID000003738
Drug	kuntai capsule	CASP8 CASP9	1.63e-04	10	44	2	ctd:C000620717
Drug	1-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane	CASP8 CASP9	1.63e-04	10	44	2	ctd:C552420
Drug	Serratamolide	CASP8 CASP9	1.63e-04	10	44	2	CID000168994
Drug	dodecylamide	CASP8 CASP9	1.63e-04	10	44	2	CID000014256
Drug	WHI-07	CASP8 CASP9	1.63e-04	10	44	2	CID005481183
Drug	benzo(e)pyrene	CASP8 CASP9	1.63e-04	10	44	2	ctd:C026487
Drug	AC1LT5W0	CASP8 CASP9	1.63e-04	10	44	2	CID001551809
Drug	austenitic steel	CASP8 CASP9	1.63e-04	10	44	2	ctd:C426023
Drug	MT-21	CASP8 CASP9	1.63e-04	10	44	2	CID000004262
Drug	11-keto-boswellic acid	CASP8 CASP9	1.63e-04	10	44	2	ctd:C447943
Drug	BDMC-A	CASP8 CASP9	1.63e-04	10	44	2	ctd:C580697
Drug	mafosfamide	CASP8 CASP9	1.63e-04	10	44	2	ctd:C048341
Drug	JS-K	CASP8 CASP9	1.63e-04	10	44	2	CID009572720
Drug	TZD18	CASP8 CASP9	1.63e-04	10	44	2	CID009827261
Drug	smilageninoside	CASP8 CASP9	1.63e-04	10	44	2	CID000197391
Drug	methyl jasmonate	CASP8 CASP9	1.63e-04	10	44	2	ctd:C072239
Disease	pre-malignant neoplasm (implicated_via_orthology)	CASP8 CASP9	7.42e-05	9	43	2	DOID:0060071 (implicated_via_orthology)
Disease	bronchopulmonary dysplasia (biomarker_via_orthology)	CASP8 CASP9	1.36e-04	12	43	2	DOID:11650 (biomarker_via_orthology)
Disease	heart disease (biomarker_via_orthology)	CASP8 CASP9	2.78e-04	17	43	2	DOID:114 (biomarker_via_orthology)
Disease	kidney disease (biomarker_via_orthology)	CASP8 CASP9	4.28e-04	21	43	2	DOID:557 (biomarker_via_orthology)
Disease	dilated cardiomyopathy (biomarker_via_orthology)	CASP8 CASP9	4.70e-04	22	43	2	DOID:12930 (biomarker_via_orthology)
Disease	Anasarca	CASP8 CASP9	6.59e-04	26	43	2	C0151603
Disease	Edema	CASP8 CASP9	6.59e-04	26	43	2	C0013604
Disease	vitamin D measurement	HAPLN4 KIF4B MED23 HSD17B11	1.44e-03	336	43	4	EFO_0004631
Disease	Huntington's disease (is_marker_for)	CASP8 CASP9	2.73e-03	53	43	2	DOID:12858 (is_marker_for)
Disease	Alzheimer's disease (biomarker_via_orthology)	CASP8 CASP9	3.26e-03	58	43	2	DOID:10652 (biomarker_via_orthology)
Disease	Adenocarcinoma of lung (disorder)	NEK1 HK1 HELLS	3.37e-03	206	43	3	C0152013
Disease	Intellectual Disability	ZNF462 HK1 MED23 ACBD6	4.02e-03	447	43	4	C3714756
Disease	Diabetes Mellitus, Non-Insulin-Dependent	CASP8 HK1 SMAD5	4.10e-03	221	43	3	C0011860

Protein segments in the cluster

Peptide	Gene	Start	Entry
QIKPFYTVKCNSAPA	AZIN1	61	O14977
PKDQFRVNGFPCKNS	ADAM7	481	Q9H2U9
FLCGPQKNKLPFDGS	ERVV-2	256	B6SEH9
KVGNCNTPKPSFFDF	ACBD6	76	Q9BR61
LCPNFVNTGFIKNPS	HSD17B11	216	Q8NBQ5
FRGFPALSQKNSPFK	NUMBL	306	Q9Y6R0
KFFFDPVRKCNGQPV	HELLS	196	Q9NRZ9
FPQSVSESCPGKFKS	HRG	496	P04196
GFSPKAQKEPCLFAN	KIF15	566	Q9NS87
PQVLFFPEGTCSNKK	LPCAT4	196	Q643R3
CLKTFSKFGSQPIPA	NEK1	276	Q96PY6
FLCGPQKNKLPFDGS	ERVV-1	256	B6SEH8
VNFSKGCPPLFTTLK	NAA16	316	Q6N069
TLSCFPGPLQAFFKQ	MED23	731	Q9ULK4
FTCPTCKKRFPDFIQ	PRDM10	616	Q9NQV6
KKLPVGFTFSFPCQQ	HK1	146	P19367
FVNMKTQGCFPQLFP	GTPBP8	246	Q8N3Z3
SIFPKCFFSGSTPIN	SCYL3	461	Q8IZE3
SCPSLGGKPKLFFIQ	CASP9	271	P55211
FPPNLVEACFKQFKT	SLC1A6	186	P48664
PSLAGKPKVFFIQAC	CASP8	346	Q14790
FFNPVCATPNSKILK	KIF4B	1156	Q2VIQ3
CFTSNLPGRVFFLKP	HAPLN4	266	Q86UW8
KPFLQRCFPDFSTKN	SLC44A5	176	Q8NCS7
EACSPQFGKTSFPTK	ATRIP	236	Q8WXE1
LKFPEAPTVKASCGF	IPO13	826	O94829
LKTLPFSPSQFFNTC	MYBL1	481	P10243
KKVCPFNGGSFLVQP	GARNL3	726	Q5VVW2
TKGSQPPRFCFQSKS	PIF1	351	Q9H611
PFAIPVAKKNCTVFA	TRMT5	311	Q32P41
SQAFVSNSPKLFCPK	PLD5	306	Q8N7P1
PGCPKSIFSGIQFIK	LIPI	236	Q6XZB0
QTVNKQFPCEPFKFL	DARS1	326	P14868
KDVFFGPKISFVIPC	SCRG1	81	O75711
PFKFVGLKNFPCTPE	SNUPN	226	O95149
EFPFGSKQKEVCINP	SMAD5	111	Q99717
CGQKQKPSFFFFKAQ	LINC00615	36	Q96LM1
TIKPFPVQKNTFRGF	VNN2	326	O95498
PVSGTICAKQAKFFF	TIGD2	96	Q4W5G0
SKFNPCGKVFTLTPG	ZNF562	176	Q6V9R5
KKGNVFPNFDPCAQA	LINC02912	11	Q8N9X5
VCSPKFQETGFFKLT	STAMBP	366	O95630
VTVPCPKVFSNFYSK	VIPR2	71	P41587
PKPTNKFFQCKFCVR	ZNF462	101	Q96JM2
NFFSFSKFKPLQCPD	ZNF597	331	Q96LX8
KSTNTFFKPPCVNVF	VEGFD	126	O43915
YKKTQCVPATFPLVF	SPATA6	41	Q9NWH7
QVFPPKCNIGKNFLS	TGFBR3	191	Q03167