Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	metalloendopeptidase activity	ADAMTS17 ADAMTS18 ADAMTS20 ADAMTS9 ADAMTSL2	7.63e-07	120	29	5	GO:0004222
GeneOntologyMolecularFunction	metallopeptidase activity	ADAMTS17 ADAMTS18 ADAMTS20 ADAMTS9 ADAMTSL2	9.36e-06	200	29	5	GO:0008237
GeneOntologyMolecularFunction	endopeptidase activity	ADAMTS17 ADAMTS18 ADAMTS20 ADAMTS9 ADAMTSL2 SENP5	3.00e-05	430	29	6	GO:0004175
GeneOntologyMolecularFunction	peptidase activity	ADAMTS17 ADAMTS18 ADAMTS20 ADAMTS9 ADAMTSL2 SENP5	3.01e-04	654	29	6	GO:0008233
GeneOntologyMolecularFunction	extracellular matrix structural constituent	THSD4 MUC5AC SPON1	2.51e-03	188	29	3	GO:0005201
GeneOntologyBiologicalProcess	extracellular matrix organization	ADAMTS17 THSD4 ADAMTS18 ADAMTS20 ADAMTSL1 ADAMTS9 ADAMTSL2	9.13e-07	377	30	7	GO:0030198
GeneOntologyBiologicalProcess	extracellular structure organization	ADAMTS17 THSD4 ADAMTS18 ADAMTS20 ADAMTSL1 ADAMTS9 ADAMTSL2	9.30e-07	378	30	7	GO:0043062
GeneOntologyBiologicalProcess	external encapsulating structure organization	ADAMTS17 THSD4 ADAMTS18 ADAMTS20 ADAMTSL1 ADAMTS9 ADAMTSL2	9.46e-07	379	30	7	GO:0045229
GeneOntologyBiologicalProcess	complement activation, alternative pathway	CFP C8A C8B	2.65e-06	19	30	3	GO:0006957
GeneOntologyBiologicalProcess	positive regulation of melanocyte differentiation	ADAMTS20 ADAMTS9	2.04e-05	5	30	2	GO:0045636
GeneOntologyBiologicalProcess	positive regulation of pigment cell differentiation	ADAMTS20 ADAMTS9	4.28e-05	7	30	2	GO:0050942
GeneOntologyBiologicalProcess	regulation of melanocyte differentiation	ADAMTS20 ADAMTS9	4.28e-05	7	30	2	GO:0045634
GeneOntologyBiologicalProcess	positive regulation of developmental pigmentation	ADAMTS20 ADAMTS9	7.32e-05	9	30	2	GO:0048087
GeneOntologyBiologicalProcess	regulation of pigment cell differentiation	ADAMTS20 ADAMTS9	7.32e-05	9	30	2	GO:0050932
GeneOntologyBiologicalProcess	complement activation	CFP C8A C8B	1.42e-04	70	30	3	GO:0006956
GeneOntologyBiologicalProcess	regulation of developmental pigmentation	ADAMTS20 ADAMTS9	2.12e-04	15	30	2	GO:0048070
GeneOntologyBiologicalProcess	regulation of pigmentation	ADAMTS20 ADAMTS9	2.74e-04	17	30	2	GO:0120305
GeneOntologyBiologicalProcess	pigmentation	ATRN ADAMTS20 ADAMTS9	7.83e-04	125	30	3	GO:0043473
GeneOntologyBiologicalProcess	melanocyte differentiation	ADAMTS20 ADAMTS9	8.10e-04	29	30	2	GO:0030318
GeneOntologyCellularComponent	extracellular matrix	ADAMTS17 THSD4 ADAMTS18 ADAMTS20 CFP ADAMTSL1 ADAMTS9 MUC5AC SPON1 ADAMTSL2	1.01e-08	656	29	10	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	ADAMTS17 THSD4 ADAMTS18 ADAMTS20 CFP ADAMTSL1 ADAMTS9 MUC5AC SPON1 ADAMTSL2	1.04e-08	658	29	10	GO:0030312
GeneOntologyCellularComponent	collagen-containing extracellular matrix	ADAMTS17 THSD4 ADAMTS20 CFP ADAMTSL1 ADAMTS9 SPON1	6.22e-06	530	29	7	GO:0062023
GeneOntologyCellularComponent	membrane attack complex	C8A C8B	3.89e-05	7	29	2	GO:0005579
GeneOntologyCellularComponent	pore complex	C8A C8B	5.92e-04	26	29	2	GO:0046930
HumanPheno	Decreased circulating complement C8 concentration	C8A C8B	3.47e-06	2	10	2	HP:0004434
HumanPheno	Decreased circulating terminal complement component concentration	C8A C8B	5.18e-05	6	10	2	HP:0033057
HumanPheno	Abnormality of complement system	CFP C8A C8B	1.85e-04	61	10	3	HP:0005339
Domain	TSP_1	ADGRB2 ADAMTS17 THSD4 ADAMTS18 ADAMTS20 CFP ADAMTSL1 THSD7B C8A C8B THSD7A ADAMTS9 SPON1 ADAMTSL2 UNC5C ADGRB1	2.32e-33	63	29	16	PF00090
Domain	TSP1	ADGRB2 ADAMTS17 THSD4 ADAMTS18 ADAMTS20 CFP ADAMTSL1 THSD7B C8A C8B THSD7A ADAMTS9 SPON1 ADAMTSL2 UNC5C ADGRB1	4.09e-33	65	29	16	SM00209
Domain	TSP1_rpt	ADGRB2 ADAMTS17 THSD4 ADAMTS18 ADAMTS20 CFP ADAMTSL1 THSD7B C8A C8B THSD7A ADAMTS9 SPON1 ADAMTSL2 UNC5C ADGRB1	4.09e-33	65	29	16	IPR000884
Domain	TSP1	ADGRB2 ADAMTS17 THSD4 ADAMTS18 ADAMTS20 CFP ADAMTSL1 THSD7B C8A C8B THSD7A ADAMTS9 SPON1 ADAMTSL2 UNC5C ADGRB1	4.09e-33	65	29	16	PS50092
Domain	ADAM_spacer1	ADAMTS17 THSD4 ADAMTS18 ADAMTS20 ADAMTS9 ADAMTSL2	8.00e-13	23	29	6	IPR010294
Domain	ADAM_spacer1	ADAMTS17 THSD4 ADAMTS18 ADAMTS20 ADAMTS9 ADAMTSL2	8.00e-13	23	29	6	PF05986
Domain	Peptidase_M12B_ADAM-TS	ADAMTS17 ADAMTS18 ADAMTS20 ADAMTSL1 ADAMTS9 ADAMTSL2	1.06e-12	24	29	6	IPR013273
Domain	PLAC	ADAMTS17 THSD4 ADAMTS18 ADAMTSL1 ADAMTSL2	1.24e-11	14	29	5	PF08686
Domain	PLAC	ADAMTS17 THSD4 ADAMTS18 ADAMTSL1 ADAMTSL2	7.19e-11	19	29	5	IPR010909
Domain	PLAC	ADAMTS17 THSD4 ADAMTS18 ADAMTSL1 ADAMTSL2	7.19e-11	19	29	5	PS50900
Domain	Peptidase_M12B_N	ADAMTS17 ADAMTS18 ADAMTS20 ADAMTS9	3.71e-07	39	29	4	IPR002870
Domain	Pep_M12B_propep	ADAMTS17 ADAMTS18 ADAMTS20 ADAMTS9	3.71e-07	39	29	4	PF01562
Domain	DISINTEGRIN_1	ADAMTS17 ADAMTS18 ADAMTS20 ADAMTS9	4.12e-07	40	29	4	PS00427
Domain	ADAM_MEPRO	ADAMTS17 ADAMTS18 ADAMTS20 ADAMTS9	4.12e-07	40	29	4	PS50215
Domain	DISINTEGRIN_2	ADAMTS17 ADAMTS18 ADAMTS20 ADAMTS9	4.12e-07	40	29	4	PS50214
Domain	Reprolysin	ADAMTS17 ADAMTS18 ADAMTS20 ADAMTS9	4.12e-07	40	29	4	PF01421
Domain	Peptidase_M12B	ADAMTS17 ADAMTS18 ADAMTS20 ADAMTS9	4.12e-07	40	29	4	IPR001590
Domain	Disintegrin_dom	ADAMTS17 ADAMTS18 ADAMTS20 ADAMTS9	4.56e-07	41	29	4	IPR001762
Domain	Pept_M12B_GON-ADAMTSs	ADAMTS20 ADAMTS9	2.33e-06	2	29	2	IPR012314
Domain	GON	ADAMTS20 ADAMTS9	2.33e-06	2	29	2	PF08685
Domain	GON	ADAMTS20 ADAMTS9	2.33e-06	2	29	2	PS51046
Domain	GPCR_2_brain_angio_inhib	ADGRB2 ADGRB1	6.98e-06	3	29	2	IPR008077
Domain	MetalloPept_cat_dom	ADAMTS17 ADAMTS18 ADAMTS20 ADAMTS9	7.18e-06	81	29	4	IPR024079
Domain	-	ADAMTS17 ADAMTS18 ADAMTS20 ADAMTS9	7.18e-06	81	29	4	3.40.390.10
Domain	ZINC_PROTEASE	ADAMTS17 ADAMTS18 ADAMTS20 ADAMTS9	1.53e-05	98	29	4	PS00142
Domain	CYSTEINE_SWITCH	ADAMTS17 ADAMTS18 ADAMTS9	3.45e-05	41	29	3	PS00546
Domain	MACPF_CS	C8A C8B	3.48e-05	6	29	2	IPR020863
Domain	Pept_M10_metallopeptidase	ADAMTS17 ADAMTS18 ADAMTS9	3.98e-05	43	29	3	IPR001818
Domain	MACPF_2	C8A C8B	4.87e-05	7	29	2	PS51412
Domain	MACPF_1	C8A C8B	4.87e-05	7	29	2	PS00279
Domain	MAC_perforin	C8A C8B	1.04e-04	10	29	2	IPR001862
Domain	MACPF	C8A C8B	1.27e-04	11	29	2	PF01823
Domain	GAIN_dom_N	ADGRB2 ADGRB1	1.27e-04	11	29	2	IPR032471
Domain	GAIN	ADGRB2 ADGRB1	1.27e-04	11	29	2	PF16489
Domain	MACPF	C8A C8B	1.52e-04	12	29	2	SM00457
Domain	MACPF	C8A C8B	1.52e-04	12	29	2	IPR020864
Domain	HormR	ADGRB2 ADGRB1	6.83e-04	25	29	2	SM00008
Domain	HRM	ADGRB2 ADGRB1	8.58e-04	28	29	2	PF02793
Domain	GPS	ADGRB2 ADGRB1	1.27e-03	34	29	2	SM00303
Domain	GPS	ADGRB2 ADGRB1	1.34e-03	35	29	2	PF01825
Domain	GPS	ADGRB2 ADGRB1	1.42e-03	36	29	2	PS50221
Domain	GPS	ADGRB2 ADGRB1	1.50e-03	37	29	2	IPR000203
Domain	G_PROTEIN_RECEP_F2_1	ADGRB2 ADGRB1	1.75e-03	40	29	2	PS00649
Domain	G_PROTEIN_RECEP_F2_3	ADGRB2 ADGRB1	1.75e-03	40	29	2	PS50227
Domain	GPCR_2_extracellular_dom	ADGRB2 ADGRB1	1.75e-03	40	29	2	IPR001879
Domain	LDLR_class-A_CS	C8A C8B	1.75e-03	40	29	2	IPR023415
Domain	Ldl_recept_a	C8A C8B	2.21e-03	45	29	2	PF00057
Domain	LDLRA_1	C8A C8B	2.51e-03	48	29	2	PS01209
Domain	LDrepeatLR_classA_rpt	C8A C8B	2.62e-03	49	29	2	IPR002172
Domain	LDLa	C8A C8B	2.62e-03	49	29	2	SM00192
Domain	CUB	ATRN SEZ6L2	2.62e-03	49	29	2	PF00431
Domain	LDLRA_2	C8A C8B	2.62e-03	49	29	2	PS50068
Domain	G_PROTEIN_RECEP_F2_2	ADGRB2 ADGRB1	2.72e-03	50	29	2	PS00650
Domain	7tm_2	ADGRB2 ADGRB1	2.72e-03	50	29	2	PF00002
Domain	CUB	ATRN SEZ6L2	2.72e-03	50	29	2	SM00042
Domain	-	ATRN SEZ6L2	2.94e-03	52	29	2	2.60.120.290
Domain	CUB	ATRN SEZ6L2	3.05e-03	53	29	2	PS01180
Domain	CUB_dom	ATRN SEZ6L2	3.52e-03	57	29	2	IPR000859
Domain	GPCR_2-like	ADGRB2 ADGRB1	3.90e-03	60	29	2	IPR017981
Domain	GPCR_2_secretin-like	ADGRB2 ADGRB1	3.90e-03	60	29	2	IPR000832
Domain	G_PROTEIN_RECEP_F2_4	ADGRB2 ADGRB1	4.02e-03	61	29	2	PS50261
Domain	EGF_3	ATRN C8A C8B	5.64e-03	235	29	3	PS50026
Domain	EGF-like_dom	ATRN C8A C8B	6.62e-03	249	29	3	IPR000742
Domain	EGF_1	ATRN C8A C8B	7.07e-03	255	29	3	PS00022
Domain	EGF-like_CS	ATRN C8A C8B	7.54e-03	261	29	3	IPR013032
Domain	EGF_2	ATRN C8A C8B	7.86e-03	265	29	3	PS01186
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS17 THSD4 ADAMTS18 ADAMTS20 CFP ADAMTSL1 THSD7B THSD7A ADAMTS9 SPON1 ADAMTSL2	1.16e-22	39	26	11	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS17 THSD4 ADAMTS18 ADAMTS20 CFP ADAMTSL1 THSD7B THSD7A ADAMTS9 SPON1 ADAMTSL2	1.16e-22	39	26	11	MM15165
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	ADAMTS17 THSD4 ADAMTS18 ADAMTS20 CFP ADAMTSL1 THSD7B THSD7A ADAMTS9 MUC5AC SPON1 ADAMTSL2	5.22e-22	68	26	12	M27303
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS17 THSD4 ADAMTS18 ADAMTS20 CFP ADAMTSL1 THSD7B THSD7A ADAMTS9 MUC5AC SPON1 ADAMTSL2	2.16e-19	109	26	12	MM15164
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS17 THSD4 ADAMTS18 ADAMTS20 CFP ADAMTSL1 THSD7B THSD7A ADAMTS9 MUC5AC SPON1 ADAMTSL2	2.72e-19	111	26	12	M27416
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	ADAMTS17 THSD4 ADAMTS18 ADAMTS20 CFP ADAMTSL1 THSD7B THSD7A ADAMTS9 MUC5AC SPON1 ADAMTSL2	6.35e-18	143	26	12	M27275
Pathway	REACTOME_DISEASES_OF_METABOLISM	ADAMTS17 THSD4 ADAMTS18 ADAMTS20 CFP ADAMTSL1 THSD7B THSD7A ADAMTS9 MUC5AC SPON1 ADAMTSL2	5.76e-15	250	26	12	M27554
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	ADAMTS17 THSD4 ADAMTS18 ADAMTS20 CFP ADAMTSL1 THSD7B THSD7A ADAMTS9 MUC5AC SPON1 ADAMTSL2 RNF135 SENP5	5.09e-08	1475	26	14	M19806
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	ADAMTS17 THSD4 ADAMTS18 ADAMTS20 CFP ADAMTSL1 THSD7B THSD7A ADAMTS9 MUC5AC SPON1 ADAMTSL2 SENP5	2.38e-07	1389	26	13	MM15307
Pathway	WP_COMPLEMENT_ACTIVATION	CFP C8A C8B	8.38e-06	22	26	3	M39502
Pathway	KEGG_MEDICUS_REFERENCE_COMMON_PATHWAY_OF_COMPLEMENT_CASCADE_MAC_FORMATION	C8A C8B	6.83e-05	7	26	2	M47873
Pathway	REACTOME_TERMINAL_PATHWAY_OF_COMPLEMENT	C8A C8B	9.10e-05	8	26	2	MM14656
Pathway	REACTOME_TERMINAL_PATHWAY_OF_COMPLEMENT	C8A C8B	9.10e-05	8	26	2	M27006
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_COMPLEMENT_CASCADE_MAC_INHIBITION	C8A C8B	1.17e-04	9	26	2	M47881
Pathway	BIOCARTA_ALTERNATIVE_PATHWAY	CFP C8A	1.17e-04	9	26	2	M22072
Pathway	WP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY	C8A C8B	4.37e-04	17	26	2	MM15944
Pathway	REACTOME_COMPLEMENT_CASCADE	CFP C8A C8B	4.81e-04	84	26	3	MM14653
Pathway	WP_COMPLEMENT_SYSTEM_IN_NEURONAL_DEVELOPMENT_AND_PLASTICITY	CFP C8A C8B	9.47e-04	106	26	3	M42535
Pathway	REACTOME_COMPLEMENT_CASCADE	CFP C8A C8B	1.20e-03	115	26	3	M19752
Pathway	KEGG_PRION_DISEASES	C8A C8B	1.87e-03	35	26	2	M13036
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADGRB2 ADAMTS17 THSD4 ADAMTS18 ADAMTS20 CFP ADAMTSL1 THSD7B THSD7A ADAMTS9 SPON1 ADAMTSL2 ADGRB1	8.45e-28	75	30	13	20637190
Pubmed	Hydrocephalus in mouse B3glct mutants is likely caused by defects in multiple B3GLCT substrates in ependymal cells and subcommissural organ.	XBP1 ADAMTS20 ADAMTS9 SPON1	1.48e-10	11	30	4	33909046
Pubmed	Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.	ADAMTS17 ADAMTS18 ADAMTS20 ADAMTS9	2.22e-10	12	30	4	25770910
Pubmed	The eighth component of human complement. Purification and physicochemical characterization of its unusual subunit structure.	C8A C8B	7.19e-07	2	30	2	7440581
Pubmed	Differential functional expression of the C8 subunits. Primary role of C8 beta in assembly of intact C8.	C8A C8B	7.19e-07	2	30	2	3171181
Pubmed	Association of genetic variations of genes encoding thrombospondin, type 1, domain-containing 4 and 7A with low bone mineral density in Japanese women with osteoporosis.	THSD4 THSD7A	7.19e-07	2	30	2	18488137
Pubmed	Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1.	ADAMTS20 ADAMTS9	7.19e-07	2	30	2	12514189
Pubmed	C-mannosylation and o-fucosylation of thrombospondin type 1 repeats.	CFP SPON1	7.19e-07	2	30	2	12096136
Pubmed	Endoplasmic reticulum stress/XBP1 promotes airway mucin secretion under the influence of neutrophil elastase.	XBP1 MUC5AC	7.19e-07	2	30	2	33760106
Pubmed	ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases.	ADAMTSL1 ADAMTSL2	2.16e-06	3	30	2	14667842
Pubmed	Degradomic Identification of Membrane Type 1-Matrix Metalloproteinase as an ADAMTS9 and ADAMTS20 Substrate.	ADAMTS20 ADAMTS9	2.16e-06	3	30	2	37169079
Pubmed	Chimeric and truncated forms of human complement protein C8 alpha reveal binding sites for C8 beta and C8 gamma within the membrane attack complex/perforin region.	C8A C8B	2.16e-06	3	30	2	10387094
Pubmed	Role of the human C8 subunits in complement-mediated bacterial killing: evidence that C8 gamma is not essential.	C8A C8B	2.16e-06	3	30	2	12413696
Pubmed	Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1).	ADGRB2 ADGRB1	2.16e-06	3	30	2	9533023
Pubmed	An indel within the C8 alpha subunit of human complement C8 mediates intracellular binding of C8 gamma and formation of C8 alpha-gamma.	C8A C8B	2.16e-06	3	30	2	11041874
Pubmed	Expression of brain-specific angiogenesis inhibitor 3 (BAI3) in normal brain and implications for BAI3 in ischemia-induced brain angiogenesis and malignant glioma.	ADGRB2 ADGRB1	2.16e-06	3	30	2	15225653
Pubmed	A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression.	ADAMTS20 ADAMTS9	2.16e-06	3	30	2	24753090
Pubmed	Chromosomal assignment of genes encoding the alpha, beta, and gamma subunits of human complement protein C8: identification of a close physical linkage between the alpha and the beta loci.	C8A C8B	2.16e-06	3	30	2	2613233
Pubmed	Comprehensive Proteoform Characterization of Plasma Complement Component C8αβγ by Hybrid Mass Spectrometry Approaches.	C8A C8B	2.16e-06	3	30	2	29532326
Pubmed	Interaction between the C8 alpha-gamma and C8 beta subunits of human complement C8: role of the C8 beta N-terminal thrombospondin type 1 module and membrane attack complex/perforin domain.	C8A C8B	4.31e-06	4	30	2	12220191
Pubmed	Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18.	ADAMTS18 ADAMTS9	4.31e-06	4	30	2	16507336
Pubmed	Evidence that C5b recognizes and mediates C8 incorporation into the cytolytic complex of complement.	C8A C8B	4.31e-06	4	30	2	3624872
Pubmed	Functional studies of the MACPF domain of human complement protein C8alpha reveal sites for simultaneous binding of C8beta, C8gamma, and C9.	C8A C8B	4.31e-06	4	30	2	16618117
Pubmed	The role of the XBP-1/AGR2 signaling pathway in the regulation of airway Mucin5ac hypersecretion under hypoxia.	XBP1 MUC5AC	4.31e-06	4	30	2	31128106
Pubmed	ADAMTS9 and ADAMTS20 are differentially affected by loss of B3GLCT in mouse model of Peters plus syndrome.	ADAMTS20 ADAMTS9	7.18e-06	5	30	2	31600785
Pubmed	The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues.	C8A C8B	7.18e-06	5	30	2	10551839
Pubmed	The gene encoding disabled-1 (DAB1), the intracellular adaptor of the Reelin pathway, reveals unusual complexity in human and mouse.	C8A C8B	1.08e-05	6	30	2	12446734
Pubmed	Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9.	C8A C8B	1.08e-05	6	30	2	22832194
Pubmed	Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.	ADAMTS17 ADAMTS18	1.51e-05	7	30	2	11867212
Pubmed	CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.	C8A C8B	1.51e-05	7	30	2	30552328
Pubmed	The secreted metalloprotease ADAMTS20 is required for melanoblast survival.	ADAMTS20 ADAMTS9	2.01e-05	8	30	2	18454205
Pubmed	Molecular organization and function of the complement system.	C8A C8B	2.01e-05	8	30	2	3052276
Pubmed	Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation.	ADAMTS20 ADAMTS9	2.01e-05	8	30	2	21041365
Pubmed	Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.	ADAMTS20 ADAMTS9 SPON1	2.33e-05	64	30	3	22261194
Pubmed	Morphogenesis of the kidney and lung requires branch-tip directed activity of the Adamts18 metalloprotease.	ADAMTS18 MUC5AC	6.50e-05	14	30	2	31242448
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	ATRN CFP C8A C8B	6.86e-05	257	30	4	16335952
Pubmed	The species-specific differences in the cAMP regulation of the tissue-type plasminogen activator gene between rat, mouse and human is caused by a one-nucleotide substitution in the cAMP-responsive element of the promoters.	ADAMTS18 MUC5AC	7.50e-05	15	30	2	7543410
Pubmed	ADAMTS18 Deficiency Affects Neuronal Morphogenesis and Reduces the Levels of Depression-like Behaviors in Mice.	ADAMTS18 ADAMTS9	8.57e-05	16	30	2	30579834
Pubmed	Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation.	ADAMTS20 ADAMTS9	9.70e-05	17	30	2	22183742
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ATRN ADAMTSL1 ADAMTSL2	1.02e-04	105	30	3	9628581
Pubmed	Genome-wide association study of liver enzymes in korean children.	THSD7B ADAMTS9	1.22e-04	19	30	2	24124411
Pubmed	Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry.	ADGRB2 ADGRB1	1.22e-04	19	30	2	12543931
Pubmed	ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.	ADAMTS20 ADAMTS9	1.35e-04	20	30	2	19922873
Pubmed	Genome-wide Identification of Foxf2 Target Genes in Palate Development.	ADAMTS9 SPON1	1.80e-04	23	30	2	32040930
Pubmed	Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene Expression in Palate Development.	ADAMTS9 SPON1	1.80e-04	23	30	2	33898467
Pubmed	ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation.	ADAMTS20 ADAMTS9	1.80e-04	23	30	2	26027930
Pubmed	Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis.	ADAMTS20 ADAMTS9	1.80e-04	23	30	2	30814516
Pubmed	Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis.	ADAMTS20 ADAMTS9	2.13e-04	25	30	2	29475039
Pubmed	The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.	ADGRB2 ADGRB1	2.88e-04	29	30	2	15203201
Pubmed	Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.	C8A C8B	3.51e-04	32	30	2	18842294
Pubmed	International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.	ADGRB2 ADGRB1	3.74e-04	33	30	2	25713288
Pubmed	Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate.	ADAMTS20 UNC5C	3.74e-04	33	30	2	18480165
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	ADAMTS17 ADAMTSL1 SPON1	4.01e-04	167	30	3	22159717
Pubmed	Tracing the origin of hair follicle stem cells.	ADAMTS17 ADAMTS20	4.20e-04	35	30	2	34108685
Pubmed	Galnt1 is required for normal heart valve development and cardiac function.	ADAMTS20 ADAMTS9	4.45e-04	36	30	2	25615642
Pubmed	O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development.	ADAMTS17 XBP1	4.45e-04	36	30	2	35167946
Pubmed	Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis.	ADAMTS18 ADAMTS9	4.96e-04	38	30	2	18267097
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	THSD7A ADAMTS9 SPON1 ADAMTSL2	8.16e-04	493	30	4	15368895
Interaction	DPY19L3 interactions	CFP C8B SPON1	5.31e-06	24	29	3	int:DPY19L3
Interaction	B3GLCT interactions	ADAMTS18 CFP ADAMTSL1	1.85e-05	36	29	3	int:B3GLCT
Interaction	C8B interactions	C8A C8B	7.15e-05	9	29	2	int:C8B
Cytoband	1p32	C8A C8B	1.43e-04	27	30	2	1p32
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS17 ADAMTS18 ADAMTS20 ADAMTS9	6.29e-09	19	22	4	50
GeneFamily	ADAMTS like	THSD4 ADAMTSL1 ADAMTSL2	5.46e-08	7	22	3	947
GeneFamily	Adhesion G protein-coupled receptors, subfamily B	ADGRB2 ADGRB1	4.24e-06	3	22	2	912
GeneFamily	Complement system\|Sushi domain containing	CFP C8A C8B	1.09e-05	36	22	3	492
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	ADAMTSL1 UNC5C	1.62e-02	161	22	2	593
Coexpression	NABA_ECM_REGULATORS	ADAMTS17 ADAMTS18 ADAMTS20 ADAMTSL1 ADAMTS9 ADAMTSL2	2.60e-07	238	30	6	M3468
Coexpression	NABA_ECM_REGULATORS	ADAMTS17 ADAMTS18 ADAMTS20 ADAMTSL1 ADAMTS9 ADAMTSL2	2.87e-07	242	30	6	MM17062
Coexpression	NABA_MATRISOME	ADAMTS17 THSD4 ADAMTS18 ADAMTS20 ADAMTSL1 ADAMTS9 MUC5AC SPON1 ADAMTSL2	1.22e-06	1008	30	9	MM17056
Coexpression	NABA_MATRISOME	ADAMTS17 THSD4 ADAMTS18 ADAMTS20 ADAMTSL1 ADAMTS9 MUC5AC SPON1 ADAMTSL2	1.42e-06	1026	30	9	M5889
Coexpression	ZENG_GU_ICB_CONTROL_METAGENE_31_PRECICTIVE_ICB_RESISTANCE	ADGRB2 ADAMTS17 ADAMTS18 ADAMTS20 ADGRB1	3.08e-06	201	30	5	MM17086
Coexpression	NABA_MATRISOME_ASSOCIATED	ADAMTS17 ADAMTS18 ADAMTS20 ADAMTSL1 ADAMTS9 MUC5AC ADAMTSL2	1.58e-05	738	30	7	MM17058
Coexpression	NABA_MATRISOME_ASSOCIATED	ADAMTS17 ADAMTS18 ADAMTS20 ADAMTSL1 ADAMTS9 MUC5AC ADAMTSL2	1.77e-05	751	30	7	M5885
Coexpression	GSE2706_LPS_VS_R848_AND_LPS_8H_STIM_DC_DN	ADGRB2 BCL2L14 SCART1 SENP5	7.14e-05	196	30	4	M4728
Coexpression	DESCARTES_FETAL_PLACENTA_SMOOTH_MUSCLE_CELLS	ADAMTS18 ADAMTS20 ADGRB1	1.44e-04	89	30	3	M40280
CoexpressionAtlas	DevelopingKidney_e13.5_podocyte cells_emap-27773_k-means-cluster#3_top-relative-expression-ranked_1000	ADGRB2 THSD4 THSD7B SPON1 UNC5C	2.05e-05	250	29	5	gudmap_developingKidney_e13.5_podocyte cells_1000_k3
ToppCell	Tuft\|World / Class top	ADGRB2 BCL2L14 C8B SEZ6L2 PIK3R5	1.50e-07	186	30	5	f4d83f15ab7b49c0920a322cd832413ece7c9948
ToppCell	Tuft-tuft-2\|World / Class top	ADGRB2 BCL2L14 C8B SEZ6L2 PIK3R5	1.54e-07	187	30	5	4ec6eee866619dfe13c84f5d2e812bb380d37139
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 SPON1 ADAMTSL2 UNC5C	1.76e-07	192	30	5	9093a9e94a25682d109a7f6edc256a25a61103a0
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 SPON1 ADAMTSL2 UNC5C	1.76e-07	192	30	5	9ed5d49621ec1aa01716dc369bba1450b5f015f5
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 SPON1 ADAMTSL2 UNC5C	1.85e-07	194	30	5	ae7df037592f1c20c9d32be15fe6fc3c562ebeb1
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 SPON1 ADAMTSL2 UNC5C	1.85e-07	194	30	5	240d122dcb9dd1ab2867503ad85869853adcacae
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 SPON1 ADAMTSL2 UNC5C	1.90e-07	195	30	5	d9a5c75d31c6e8bb1e1ab7fd115ac5deb5fb1c8d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 SPON1 ADAMTSL2 UNC5C	1.90e-07	195	30	5	44d7bef5f59c2c2bad1392ee6aabdaa5d7f531d9
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 SPON1 ADAMTSL2 UNC5C	1.94e-07	196	30	5	a12dd986df65c36f248cf10815c3b8b6238613b0
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 SPON1 ADAMTSL2 UNC5C	1.94e-07	196	30	5	3e6803587d8566fd08cb8b290be3b6461743d79c
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 SPON1 ADAMTSL2 UNC5C	1.99e-07	197	30	5	b349f8e96d61a4c296af64711e11fc44459a9413
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 SPON1 ADAMTSL2 UNC5C	1.99e-07	197	30	5	6d027119a5f7ca2aac1b10837e43f9a2bb54db85
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 SPON1 ADAMTSL2 UNC5C	1.99e-07	197	30	5	c2e390653d5dee7e731c1840cfdab41987dede9b
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_immature\|E16.5-samps / Age Group, Lineage, Cell class and subclass	ADAMTS20 THSD7B RNF135 ADGRB1	1.67e-06	129	30	4	5e4783cc63afdeaebdfaecb72f95f3efc8d3c4a3
ToppCell	21-Trachea-Epithelial-Submucosal_gland_basal\|Trachea / Age, Tissue, Lineage and Cell class	ADAMTS18 THSD7B ADAMTS9 ADGRB1	3.83e-06	159	30	4	4f670b57b8d3b090ea2f1aafe15baf93cb7ef146
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell-D122\|Adult / Lineage, Cell type, age group and donor	ADGRB2 ADAMTSL1 ADAMTS9 UNC5C	3.93e-06	160	30	4	fd14dfeb7021a4b7299371854dc8fc1fd66c8dae
ToppCell	P07-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADAMTS17 MUC5AC SPON1 UNC5C	4.03e-06	161	30	4	b19f82dd98a3064581793711bb70373f18abecd9
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 SPON1 ADAMTSL2 UNC5C	5.73e-06	176	30	4	9bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 SPON1 ADAMTSL2 UNC5C	5.73e-06	176	30	4	3f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS18 ADAMTSL1 THSD7B THSD7A	6.12e-06	179	30	4	e6ae070b4c52ba08167c7d64ea4cfbac0454c1bf
ToppCell	Control-Fibroblasts-Airway_smooth_muscle\|Control / group, cell type (main and fine annotations)	THSD4 ADAMTSL1 THSD7B UNC5C	6.26e-06	180	30	4	d0de12749ef0f51f0931c6e7b9b99966bdbc3ec1
ToppCell	18-Airway-Epithelial-Submucosal_gland_basal\|Airway / Age, Tissue, Lineage and Cell class	ADAMTS17 ADAMTS18 THSD7B ADGRB1	6.40e-06	181	30	4	33938e6521712058312879f84f4ae381c2bfc379
ToppCell	RA-07._Pericyte\|World / Chamber and Cluster_Paper	THSD7B THSD7A ADAMTS9 UNC5C	6.54e-06	182	30	4	2075efeae633550fb2eb026d0dfd741c8252482e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 SPON1 ADAMTSL2	6.54e-06	182	30	4	44764676ed3f51ba171ce63f669390392fa50a43
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 SPON1 ADAMTSL2	6.54e-06	182	30	4	d82f59a3f930a840dde27dc6ab024f227a26d446
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 SPON1 ADAMTSL2 UNC5C	6.83e-06	184	30	4	c5436a8e45f471b8d1301abbe9c7879204537f52
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D122\|Adult / Lineage, Cell type, age group and donor	ADAMTSL1 SPON1 ADAMTSL2 UNC5C	6.83e-06	184	30	4	2b7e6f91e11c228f0521e099886867d9e998e78d
ToppCell	COVID-19-kidney-Fibroblast-1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	THSD4 ADAMTSL1 SPON1 ADAMTSL2	7.28e-06	187	30	4	76bfe8c42430a230a8bdf299575c444fb7780f24
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	ADAMTS17 SPON1 ADAMTSL2 UNC5C	7.28e-06	187	30	4	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 SPON1 ADAMTSL2 UNC5C	7.59e-06	189	30	4	71397e993a77d70b2eeede240bdfc7660b558987
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 SPON1 ADAMTSL2 UNC5C	7.59e-06	189	30	4	4eea4759520c312bd17a681034d8074e47093d2b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 ADAMTSL2 UNC5C	7.75e-06	190	30	4	1f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 ADAMTSL2 UNC5C	7.75e-06	190	30	4	2306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS17 THSD4 THSD7A SPON1	7.75e-06	190	30	4	1bbbf0ce222e51f9fd2daca0c18d3965fd4efd31
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 ADAMTSL2 UNC5C	7.91e-06	191	30	4	a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 SPON1 ADAMTSL2 UNC5C	7.91e-06	191	30	4	107113b930d9ad171f1b2aa20df4567c94fae7d8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 SPON1 ADAMTSL2 UNC5C	7.91e-06	191	30	4	bc353a79a1d11ca52bba5e3874a80d432e1a7715
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 SPON1 ADAMTSL2	8.08e-06	192	30	4	bc84b9ce01b4d826a682842ab8a395dac9b91183
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS17 SPON1 ADAMTSL2 UNC5C	8.08e-06	192	30	4	de9c1536d5aee86f9c62acbc54ca8fa581c00f17
ToppCell	PND14-Mesenchymal-Mesenchymal_structural\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS17 SPON1 ADAMTSL2 UNC5C	8.08e-06	192	30	4	25492568f9cbe097b7bb1db50d8b817c80ea87d7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 SPON1 ADAMTSL2	8.08e-06	192	30	4	0ab1176cfbb0de8dd1f22c6e2c41265cf6c10ee1
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 ADAMTSL2 UNC5C	8.24e-06	193	30	4	f1199518c3626fd29bfce65070dd21a660671213
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTS18 ADAMTSL1 SPON1	8.24e-06	193	30	4	1f978e102a029a6beb10913052cd0a20c7253e8e
ToppCell	(07)_Brush\|World / shred by cell type and Timepoint	ADGRB2 BCL2L14 SEZ6L2 PIK3R5	8.24e-06	193	30	4	9af9d22a130ff97a9c37142a65e841b056d08640
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADAMTS17 SPON1 ADAMTSL2 UNC5C	8.24e-06	193	30	4	99525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 SPON1 ADAMTSL2	8.41e-06	194	30	4	81713e0409e8be695ba5dfdc67a997b33435dd9e
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADAMTS17 SPON1 ADAMTSL2 UNC5C	8.41e-06	194	30	4	e93de9428c986b8943fc169258847c650cfab0e5
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 SPON1 ADAMTSL2	8.41e-06	194	30	4	e03ba6caed59fa64d4d9b042593469d4a6a3dc10
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 SPON1 ADAMTSL2	8.41e-06	194	30	4	627cffe2d448e74fc5df92e74e5b922a73304137
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTSL1 SPON1 ADAMTSL2 UNC5C	8.58e-06	195	30	4	d8ebb94f30d4a655d6b29dd6a3076be2403d2356
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 ADAMTSL2 UNC5C	8.58e-06	195	30	4	803f714d91f2d97ecbee8c15a5139fd9310f66c7
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS17 SPON1 ADAMTSL2 UNC5C	8.58e-06	195	30	4	3a0cad69cfc150a27a0666f612f5294c817197d7
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 ADAMTSL2 UNC5C	8.58e-06	195	30	4	4f70157d42a16ff0259bc24a62803c4df4285c44
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS17 SPON1 ADAMTSL2 UNC5C	8.58e-06	195	30	4	2b8ee7990267bb52b7e6ae03f509ffebf8908122
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTSL1 SPON1 ADAMTSL2 UNC5C	8.76e-06	196	30	4	ba869f7a86f37fd6d84d6ad69baca0e0faaf5887
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTSL1 SPON1 ADAMTSL2 UNC5C	8.76e-06	196	30	4	30ad56d49000e4ddce73b4443b3994564bd1e2d6
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAMTS18 ADAMTSL1 THSD7A ADAMTS9	8.76e-06	196	30	4	5609b2d93172a488b35d854298a3a4e504e17e28
ToppCell	10x5'v1-week_17-19-Mesenchymal_osteo-stroma-osteoblast_precursor\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	THSD4 ADAMTSL1 ADAMTS9 SPON1	8.76e-06	196	30	4	57df2a57b35be9851ac0b1e5731baa53052511f0
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 SPON1 ADAMTSL2	8.94e-06	197	30	4	9b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 ADAMTSL2 UNC5C	8.94e-06	197	30	4	80e153790cef37b743e22a7370ff5b3a6abf147d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 SPON1 ADAMTSL2	9.12e-06	198	30	4	a860246bcea847249a78fd2e86ed8e04371060db
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-NPM1P10--L5-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ADAMTS18 ADAMTS20 THSD7B SPON1	9.49e-06	200	30	4	2ea33ac1970791e6a601ac1e407ef32e4833792d
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS17 SPON1 ADAMTSL2 UNC5C	9.49e-06	200	30	4	34f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-NPM1P10\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ADAMTS18 ADAMTS20 THSD7B SPON1	9.49e-06	200	30	4	7b3284bf0000e14f5a51e4422231e5639a184579
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-NPM1P10-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ADAMTS18 ADAMTS20 THSD7B SPON1	9.49e-06	200	30	4	e957f5926675f6c29208cfc3203a19dab538df38
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Desmoid_Tumor\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	ADAMTS20 ADAMTS9 SPON1	6.95e-05	119	30	3	d8fbea9ded96fcc3ebdfb4d28873c563427ce811
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Desmoid_Tumor-7\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	ADAMTS20 ADAMTS9 SPON1	6.95e-05	119	30	3	9e38f13bf98b9ee44b178300e6f80fd08a006296
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ADAMTS20 C8B THSD7A	1.10e-04	139	30	3	fa0eedebf53317928022c3bed391ce99a2114f98
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_ALM_Tgfb1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	THSD4 ADAMTS18 SPON1	1.25e-04	145	30	3	84d50a13b48d50c16e768422908e371a55972d0e
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ADAMTS20 ADAMTSL1 THSD7B	1.33e-04	148	30	3	d6ac5972267254651dfbe16bb4e9a62228093cc7
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	XBP1 BCL2L14 MUC5AC	1.52e-04	155	30	3	62b59cb32b12bd55b19e98786a866d788fc9e4bf
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	THSD4 SPON1 ADAMTSL2	1.58e-04	157	30	3	b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_ISOC1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS20 THSD7B SPON1	1.61e-04	158	30	3	b70b4dbcb0ee96d98578c14e89b1c3f74e84c517
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1\|E16.5-samps / Age Group, Lineage, Cell class and subclass	ADAMTS17 SPON1 ADAMTSL2	1.76e-04	163	30	3	f1ec2625b52664308968b01d8e0275e1e0751480
ToppCell	facs-MAT-Fat-3m-Myeloid-macrophage\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCL2L14 CFP PIK3R5	1.80e-04	164	30	3	b81498c3934e0d52bf0329dc745e02966f9d8613
ToppCell	356C-Endothelial_cells-Endothelial-F_(Lymphatics)\|356C / Donor, Lineage, Cell class and subclass (all cells)	THSD4 ADAMTS18 ADAMTS9	1.86e-04	166	30	3	6bd5aa205b6e4b88ba9f8cd0999e2191d7d1d16c
ToppCell	356C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	THSD4 ADAMTS18 ADAMTS9	1.86e-04	166	30	3	5ba45407a47207ff01e4a3f9f5d91d8247fe9b6f
ToppCell	Adult-Epithelial-lung_goblet_cell-D122\|Adult / Lineage, Cell type, age group and donor	XBP1 ADAMTSL1 MUC5AC	1.89e-04	167	30	3	6efbb2ef6adc8da5dd67210969f825f5cc8ed022
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic-Myeloid-Lymphoid_DC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BCL2L14 CFP APOBEC3H	1.93e-04	168	30	3	6dd58fd981750da49afd53796f244e1803cce97f
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-5_VIP_KCNJ2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS18 THSD7B THSD7A	1.96e-04	169	30	3	d161dd8eb22633392b6c6466ee9eff4042464149
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 SPON1 ADAMTSL2	1.96e-04	169	30	3	a84490724a206c9bbb145f7ce08613f91d100ac4
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADAMTS17 SPON1 UNC5C	2.00e-04	170	30	3	7fa022471e14ac8a3bc147c793368a4d56a8e591
ToppCell	ILEUM-non-inflamed-(3)_mature_DC\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	BCL2L14 CFP ADGRB1	2.00e-04	170	30	3	60151394460e6f27a42fab434e8b7b2adc78b128
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAMTS18 THSD7A ADAMTS9	2.00e-04	170	30	3	1a568efcff9c39b3f709b55a05d24710450a2657
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAMTS18 THSD7A ADAMTS9	2.00e-04	170	30	3	66d41d794790e621d72ac37af995510537103c9c
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_KLHL14\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS20 THSD7B SPON1	2.03e-04	171	30	3	a6ed4d5b9d552017dd0958face45167e93cf3e8c
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7B THSD7A SEZ6L2	2.03e-04	171	30	3	a5634b76476b8b2488a706bbab5141f7bd94631f
ToppCell	ILEUM-non-inflamed-(3)_MNP-(3)_mature_DC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	BCL2L14 SPON1 ADGRB1	2.03e-04	171	30	3	341f9f79c1ed654ab347e25dc4936f89ffdf9617
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_ISOC1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS18 ADAMTS20 THSD7B	2.07e-04	172	30	3	4f2303dee1f816093e580ea8a4a8d7e3e4f36368
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell\|Adult / Lineage, Cell type, age group and donor	ADGRB2 ADAMTSL1 UNC5C	2.07e-04	172	30	3	c62cad0f4212d1e9ea1ec3143ad3c4e06aff0ebf
ToppCell	facs-Marrow-B-cells-24m-Hematologic-Unknown_Progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XBP1 ADAMTS18 SPON1	2.07e-04	172	30	3	65b8935a972bf00b7a10dc2d442128fc0ed78bcb
ToppCell	facs-Marrow-B-cells-24m-Hematologic-hematopoietic_stem_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XBP1 C8B SPON1	2.07e-04	172	30	3	a7fd4d61fb5017dce001d69d6b9a01e6cdf58828
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_ISOC1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS20 THSD7B SPON1	2.07e-04	172	30	3	fee9c4e80c682e093748f873c9c462b68ebe9b79
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4-5_RORB_ASCL1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS17 THSD7A SPON1	2.10e-04	173	30	3	2e35bf2b5534a289d93a09faae660f665c131062
ToppCell	-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	SPON1 ADAMTSL2 UNC5C	2.10e-04	173	30	3	88be9182fbb1bc83531cd41e59ea57c112a21d54
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	THSD4 BCL2L14 THSD7A	2.10e-04	173	30	3	b799c06a6a5754668e789f70c0c8bc1508568575
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-5_VIP_KCNJ2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTSL1 THSD7B THSD7A	2.14e-04	174	30	3	fdadac1eaab2c4a67e4832f0901df22e893add6a
ToppCell	P15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADAMTS17 SPON1 ADAMTSL2	2.14e-04	174	30	3	3c47d069bd836599a8d40eae485c23d4d3487517
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_KLHL14\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS20 THSD7B SPON1	2.17e-04	175	30	3	c2f7193158b225b7b7def29104295a54574e01c7
ToppCell	AT1-AT2_cells-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	THSD4 THSD7A ADAMTS9	2.17e-04	175	30	3	bdd85ba280648a0283c1984662a34c7b840f64dd
Drug	Tinidazole [19387-91-8]; Up 200; 16.2uM; PC3; HT_HG-U133A	THSD4 CFP MUC5AC PIK3R5 ADGRB1	3.76e-06	196	28	5	4548_UP
Drug	Piperacillin sodium salt [59703-84-3]; Up 200; 7.4uM; MCF7; HT_HG-U133A	ADGRB2 C8B MUC5AC PIK3R5 SPON1	3.85e-06	197	28	5	3939_UP
Drug	Al per	CFP C8A C8B	1.48e-05	39	28	3	CID009576740
Drug	tegafur	ADAMTS17 ADAMTS18 ADAMTS20	2.95e-05	49	28	3	CID000005386
Drug	Suloctidil [54063-56-8]; Up 200; 11.8uM; PC3; HT_HG-U133A	ADGRB2 C8A THSD7A MUC5AC	7.57e-05	186	28	4	6675_UP
Drug	Mianserine hydrochloride [21535-47-7]; Up 200; 13.2uM; MCF7; HT_HG-U133A	ADGRB2 CFP MUC5AC AGPAT3	8.06e-05	189	28	4	2231_UP
Drug	Dipyridamole [58-32-2]; Up 200; 8uM; PC3; HT_HG-U133A	ADGRB2 THSD4 MUC5AC SENP5	9.28e-05	196	28	4	4656_UP
Drug	Acacetin [480-44-4]; Up 200; 14uM; PC3; HT_HG-U133A	C8B ADAMTS9 PIK3R5 SENP5	9.65e-05	198	28	4	3767_UP
Drug	Lisuride (S)(-) [18016-80-3]; Up 200; 11.8uM; PC3; HT_HG-U133A	CFP C8A C8B SPON1	9.65e-05	198	28	4	6682_UP
Drug	Flurbiprofen [5104-49-4]; Up 200; 16.4uM; MCF7; HT_HG-U133A	THSD4 ADAMTS20 CFP PIK3R5	9.84e-05	199	28	4	5269_UP
Drug	Dehydroisoandosterone 3-acetate [853-23-6]; Up 200; 12.2uM; HL60; HT_HG-U133A	CFP C8A THSD7A SEZ6L2	9.84e-05	199	28	4	3097_UP
Drug	Tolbutamide [64-77-7]; Up 200; 14.8uM; MCF7; HT_HG-U133A	CFP C8B SPON1 SENP5	9.84e-05	199	28	4	4362_UP
Drug	C11998	CFP MUC5AC	1.52e-04	15	28	2	CID005282036
Disease	Meningitis	C8A C8B	3.00e-06	3	30	2	C0025289
Disease	Neisseriaceae Infections	C8A C8B	3.00e-06	3	30	2	C0085396
Disease	Pachymeningitis	C8A C8B	3.00e-06	3	30	2	C0030167
Disease	Complement deficiency disease	CFP C8A C8B	5.07e-06	33	30	3	C0272242
Disease	semenogelin-1 measurement	C8A C8B	1.50e-05	6	30	2	EFO_0802051
Disease	sulfatase-modifying factor 1 measurement	C8A C8B	2.79e-05	8	30	2	EFO_0802098
Disease	neurexophilin-1 measurement	C8A C8B	2.79e-05	8	30	2	EFO_0008244
Disease	WNT1-inducible-signaling pathway protein 1 measurement	C8A C8B	4.47e-05	10	30	2	EFO_0008321
Disease	cortical surface area measurement, neuroimaging measurement	THSD4 ADAMTS18 ADAMTS20 ADAMTS9	7.99e-05	227	30	4	EFO_0004346, EFO_0010736
Disease	Antibody Deficiency Syndrome	C8A C8B	1.35e-04	17	30	2	C0003257
Disease	intraocular pressure measurement	ADGRB2 ADAMTS17 ADAMTS18 ADAMTS20 THSD7A	1.49e-04	509	30	5	EFO_0004695
Disease	non-alcoholic fatty liver disease, type 2 diabetes mellitus	ADAMTS18 ATRN ADAMTSL1	1.90e-04	110	30	3	EFO_0003095, MONDO_0005148
Disease	brain measurement, neuroimaging measurement	THSD4 ADAMTS18 ADAMTS20 ADAMTS9 RNF135	2.14e-04	550	30	5	EFO_0004346, EFO_0004464
Disease	Immunologic Deficiency Syndromes	C8A C8B	2.49e-04	23	30	2	C0021051
Disease	response to angiotensin-converting enzyme inhibitor, response to angiotensin receptor blocker, angioedema	ADAMTSL1 THSD7A	3.20e-04	26	30	2	EFO_0005325, EFO_0005532, EFO_0010735
Disease	Growth Disorders	ADAMTSL2 RNF135	6.16e-04	36	30	2	C0018273
Disease	body fat distribution	ADAMTS17 ADAMTSL1 SEZ6L2	1.12e-03	202	30	3	EFO_0004341
Disease	cortical surface area measurement	THSD4 ADAMTS18 ADAMTS20 ADAMTSL1 ADAMTS9 UNC5C	2.05e-03	1345	30	6	EFO_0010736
Disease	interstitial lung disease	THSD7B MUC5AC	2.12e-03	67	30	2	EFO_0004244
Disease	response to anticonvulsant	ADAMTS20 THSD7A	3.39e-03	85	30	2	GO_0036277
Disease	carpal tunnel syndrome	ADAMTS17 ADAMTSL2	3.70e-03	89	30	2	EFO_0004143
Disease	central corneal thickness	ADAMTS17 ADAMTS18 ADAMTS20	3.75e-03	309	30	3	EFO_0005213
Disease	susceptibility to pneumonia measurement	MUC5AC UNC5C	4.38e-03	97	30	2	EFO_0008410
Disease	Abnormality of refraction	ADAMTS20 ADAMTSL1 THSD7A ADAMTS9	4.59e-03	673	30	4	HP_0000539

Protein segments in the cluster

Peptide	Gene	Start	Entry
AAEEWSPWSVCSLTC	ADGRB2	311	O60241
PVTTCWDCTTWSTNQ	ERV3-1	161	Q14264
AVTCQLSNWSEWTDC	C8A	36	P07357
AAEEWSPWSVCSSTC	ADGRB1	356	O14514
TWSPCSSCAWELVDF	APOBEC3H	81	Q6NTF7
CSANESWTEVSWPCR	BCL2L14	61	Q9BZR8
CLSIWEASEWSQCSA	ADAMTS17	921	Q8TE56
WVASSWSECSATCGL	ADAMTS18	1056	Q8TE60
SCPSWAASEWSECLV	ADAMTS20	1021	P59510
CVWNTGSSQCISWAL	ATRN	666	O75882
EWLLSDWTECSTSCG	ADAMTSL1	791	Q8N6G6
ECQPRWETSSWSECS	ADAMTSL2	621	Q86TH1
WETSSWSECSRTCGE	ADAMTSL2	626	Q86TH1
STSSCLQELCTWTEW	MUC5AC	1946	P98088
SLWSTWAPCSVTCSE	CFP	81	P27918
QWKALDWSSCSVTCG	ADAMTS9	1241	Q9P2N4
ELSSWSSWTTCDPCQ	C8B	66	P07358
SCCVEWKGTSQLSAW	RNF135	346	Q8IUD6
LLSPWSEWSDCSVTC	SPON1	616	Q9HCB6
LTEWSQWSECNKSCG	SPON1	671	Q9HCB6
CQVSEWSEWSPCSKT	THSD7A	361	Q9UPZ6
CPKDCVLSTWSTWSS	THSD7A	631	Q9UPZ6
VLSTWSTWSSCSHTC	THSD7A	636	Q9UPZ6
NCQLSDWSPWSECSQ	THSD7A	1286	Q9UPZ6
DWSPWSECSQTCGLT	THSD7A	1291	Q9UPZ6
YLKDWSSWSLCQLTC	THSD7A	1416	Q9UPZ6
LISCWAFWTTWTQSC	XBP1	201	P17861
SDILTCQWDLSWSAA	SEZ6L2	681	Q6UXD5
ALSWSQETTKTWCIF	SPATA31C1	291	P0DKV0
WDQSSCSSPKWECTE	SENP5	356	Q96HI0
EWWSCTECTLFTDQA	AGPAT3	66	Q9NRZ7
TSWSAGLCLNCWSLQ	PIK3R5	31	Q8WYR1
ESSLWECSLGSWCQS	SCART1	101	Q4G0T1
WTGHVSTSWSINCCD	RALGAPB	1211	Q86X10
DCETSQWSSWSPCSK	THSD7B	336	Q9C0I4
CSTDCIVSSWSAWGL	THSD7B	481	Q9C0I4
DCVLSEWTEWSSCSQ	THSD7B	601	Q9C0I4
EWTEWSSCSQSCSNK	THSD7B	606	Q9C0I4
CKLSDWSSWGSCSSS	THSD7B	1001	Q9C0I4
VNCQLSGWTAWTECS	THSD7B	1246	Q9C0I4
CHLTEWSEWSTCELT	THSD7B	1371	Q9C0I4
CSEWQIRTDWTSCSV	THSD4	736	Q6ZMP0
WCQCVAWSSAGTTKS	UNC5C	141	O95185