Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone binding	SFMBT1 TDRD3 KDM4C RNF8 CHD8 CHD4 TAF1 PRMT7 TAF1L NPM2	3.58e-07	265	91	10	GO:0042393
GeneOntologyMolecularFunction	methylated histone binding	TDRD3 KDM4C CHD8 TAF1 TAF1L	4.58e-05	86	91	5	GO:0035064
GeneOntologyMolecularFunction	methylation-dependent protein binding	TDRD3 KDM4C CHD8 TAF1 TAF1L	5.12e-05	88	91	5	GO:0140034
GeneOntologyMolecularFunction	H3K27me3 modified histone binding	TAF1 TAF1L	2.04e-04	5	91	2	GO:0061628
GeneOntologyMolecularFunction	modification-dependent protein binding	TDRD3 KDM4C TOPBP1 CHD8 TAF1 TAF1L	3.61e-04	206	91	6	GO:0140030
GeneOntologyMolecularFunction	ubiquitin conjugating enzyme activity	TAF1 UBE2U TAF1L	6.36e-04	37	91	3	GO:0061631
GeneOntologyMolecularFunction	RNA polymerase I general transcription initiation factor activity	TAF1 TAF1L	7.24e-04	9	91	2	GO:0001181
GeneOntologyMolecularFunction	gated channel activity	GABRB2 ANO2 KCNC1 KCNH1 TRPC3 ANO1 CHRNE	8.37e-04	334	91	7	GO:0022836
GeneOntologyMolecularFunction	ATP hydrolysis activity	KIF13B KIF9 RHOBTB3 ATP11C CHD8 AK9 CHD4 ATP2A3	9.11e-04	441	91	8	GO:0016887
GeneOntologyMolecularFunction	14-3-3 protein binding	KIF13B KCNH1 PI4KB	9.24e-04	42	91	3	GO:0071889
GeneOntologyMolecularFunction	ubiquitin-like protein conjugating enzyme activity	TAF1 UBE2U TAF1L	9.90e-04	43	91	3	GO:0061650
GeneOntologyMolecularFunction	ligand-gated monoatomic anion channel activity	GABRB2 ANO2 ANO1	1.54e-03	50	91	3	GO:0099095
GeneOntologyMolecularFunction	intramembrane lipid transporter activity	ANO2 ANO1 ATP11C	1.63e-03	51	91	3	GO:0140303
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	GABRB2 ANO2 TRPC3 ANO1 CHRNE	1.90e-03	193	91	5	GO:0015276
GeneOntologyMolecularFunction	ATP-dependent activity	KIF13B KIF9 RHOBTB3 ATP11C CHD8 AK9 CHD4 ATP2A3 NPM2	1.93e-03	614	91	9	GO:0140657
GeneOntologyMolecularFunction	ligand-gated channel activity	GABRB2 ANO2 TRPC3 ANO1 CHRNE	2.08e-03	197	91	5	GO:0022834
GeneOntologyMolecularFunction	transcription factor binding	HDAC11 KDM4C ZNF644 MAP3K10 IPO13 DAPK3 CHD4 TAF1 BSN TAF1L	2.24e-03	753	91	10	GO:0008134
GeneOntologyBiologicalProcess	chromatin organization	ATG5 SFMBT1 HDAC11 TDRD3 PHF20 KDM4C SUPT5H RNF8 TOPBP1 DAPK3 CHD8 CHD4 TAF1 PRMT7 TAF1L NPM2	1.72e-06	896	91	16	GO:0006325
GeneOntologyBiologicalProcess	protein-DNA complex organization	ATG5 SFMBT1 HDAC11 TDRD3 PHF20 KDM4C SUPT5H RNF8 TOPBP1 DAPK3 CHD8 CHD4 TAF1 PRMT7 TAF1L NPM2	6.92e-06	999	91	16	GO:0071824
GeneOntologyCellularComponent	MLL1 complex	PHF20 CHD8 TAF1 TAF1L	1.05e-05	32	90	4	GO:0071339
GeneOntologyCellularComponent	MLL1/2 complex	PHF20 CHD8 TAF1 TAF1L	1.19e-05	33	90	4	GO:0044665
GeneOntologyCellularComponent	histone methyltransferase complex	PHF20 CHD8 TAF1 TAF1L	3.09e-04	75	90	4	GO:0035097
Domain	TFIID_sub1_DUF3591	TAF1 TAF1L	2.25e-05	2	89	2	IPR022591
Domain	TBP-binding	TAF1 TAF1L	2.25e-05	2	89	2	PF09247
Domain	DUF3591	TAF1 TAF1L	2.25e-05	2	89	2	PF12157
Domain	TAF_II_230-bd	TAF1 TAF1L	2.25e-05	2	89	2	IPR009067
Domain	-	TAF1 TAF1L	2.25e-05	2	89	2	1.10.1100.10
Domain	TAF1_animal	TAF1 TAF1L	2.25e-05	2	89	2	IPR011177
Domain	PRO_ENDOPEP_SER	DPP4 PREPL	2.22e-04	5	89	2	PS00708
Domain	TUDOR	TDRD3 PHF20 KDM4C	2.82e-04	27	89	3	SM00333
Domain	Tudor	TDRD3 PHF20 KDM4C	3.87e-04	30	89	3	IPR002999
Domain	Anoct_dimer	ANO2 ANO1	4.64e-04	7	89	2	PF16178
Domain	Anoct_dimer	ANO2 ANO1	4.64e-04	7	89	2	IPR032394
Domain	PKD/Chitinase_dom	KIAA0319 SORCS2	7.91e-04	9	89	2	IPR022409
Domain	PKD	KIAA0319 SORCS2	7.91e-04	9	89	2	SM00089
Domain	Anoctamin	ANO2 ANO1	9.86e-04	10	89	2	PF04547
Domain	Anoctamin	ANO2 ANO1	9.86e-04	10	89	2	IPR007632
Domain	PKD	KIAA0319 SORCS2	1.20e-03	11	89	2	PS50093
Domain	Peptidase_S9	DPP4 PREPL	1.20e-03	11	89	2	PF00326
Domain	PKD_dom	KIAA0319 SORCS2	1.20e-03	11	89	2	IPR000601
Domain	Peptidase_S9	DPP4 PREPL	1.20e-03	11	89	2	IPR001375
Domain	-	KIAA0319 SORCS2	1.20e-03	11	89	2	2.60.40.670
Domain	FN3	KIAA0319 FNDC3B PHYHIP PHYHIPL SDK1	1.92e-03	185	89	5	SM00060
Domain	FN3_dom	KIAA0319 FNDC3B PHYHIP PHYHIPL SDK1	3.24e-03	209	89	5	IPR003961
Domain	Pept_M10A_stromelysin-type	MMP11 MMP19	3.27e-03	18	89	2	IPR016293
Domain	Hemopexin-like_dom	MMP11 MMP19	5.32e-03	23	89	2	IPR000585
Domain	Hemopexin-like_repeat	MMP11 MMP19	5.32e-03	23	89	2	IPR018487
Domain	HEMOPEXIN	MMP11 MMP19	5.32e-03	23	89	2	PS00024
Domain	-	MMP11 MMP19	5.32e-03	23	89	2	2.110.10.10
Domain	TUDOR	TDRD3 KDM4C	5.32e-03	23	89	2	PS50304
Domain	HEMOPEXIN_2	MMP11 MMP19	5.32e-03	23	89	2	PS51642
Domain	HX	MMP11 MMP19	5.32e-03	23	89	2	SM00120
Domain	M10A_MMP	MMP11 MMP19	5.32e-03	23	89	2	IPR033739
Domain	Hemopexin	MMP11 MMP19	5.32e-03	23	89	2	PF00045
Domain	Pept_M10A	MMP11 MMP19	5.32e-03	23	89	2	IPR021190
Domain	Znf_FYVE_PHD	PHF20 KDM4C CHD4 BSN	5.36e-03	147	89	4	IPR011011
Domain	Peptidase_M10	MMP11 MMP19	5.79e-03	24	89	2	PF00413
Domain	Chromo_domain	CHD8 CHD4	5.79e-03	24	89	2	IPR023780
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZNF608 BCLAF1 RHOBTB3 CASKIN1 HECTD4 TOPBP1 IPO13 CHD8 BSN PREPL GPATCH2L	1.61e-07	529	92	11	14621295
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	KIAA0319 KIF13B TDRD3 MAGED1 BCLAF1 CASKIN1 EIF4G1 HECTD4 DAPK3 CHD8 CHD4 BSN NOP2 PREPL	2.41e-07	963	92	14	28671696
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	TDRD3 BCLAF1 EIF4G1 TOPBP1 TFIP11 CHD8 CHD4 TAF1 TAF1L	6.33e-07	370	92	9	22922362
Pubmed	TMEM16A-TMEM16B chimaeras to investigate the structure-function relationship of calcium-activated chloride channels.	ANO2 ANO1	6.92e-06	2	92	2	23570556
Pubmed	Developmental expression of the calcium-activated chloride channels TMEM16A and TMEM16B in the mouse olfactory epithelium.	ANO2 ANO1	6.92e-06	2	92	2	24318978
Pubmed	Calcium-activated chloride channels anoctamin 1 and 2 promote murine uterine smooth muscle contractility.	ANO2 ANO1	6.92e-06	2	92	2	24928056
Pubmed	Bassoon Controls Presynaptic Autophagy through Atg5.	ATG5 BSN	6.92e-06	2	92	2	28231469
Pubmed	The Cl--channel TMEM16A is involved in the generation of cochlear Ca2+ waves and promotes the refinement of auditory brainstem networks in mice.	ANO2 ANO1	6.92e-06	2	92	2	35129434
Pubmed	Taf1 knockout is lethal in embryonic male mice and heterozygous females show weight and movement disorders.	TAF1 TAF1L	6.92e-06	2	92	2	38804708
Pubmed	TAFII250, Egr-1, and D-type cyclin expression in mice and neonatal rat cardiomyocytes treated with doxorubicin.	TAF1 TAF1L	6.92e-06	2	92	2	10070062
Pubmed	Preassociated apocalmodulin mediates Ca2+-dependent sensitization of activation and inactivation of TMEM16A/16B Ca2+-gated Cl- channels.	ANO2 ANO1	6.92e-06	2	92	2	25489088
Pubmed	Sustained expression of a neuron-specific isoform of the Taf1 gene in development stages and aging in mice.	TAF1 TAF1L	6.92e-06	2	92	2	22842574
Pubmed	Calcium-activated chloride channels (CaCCs) regulate action potential and synaptic response in hippocampal neurons.	ANO2 ANO1	6.92e-06	2	92	2	22500639
Pubmed	Frameshift Mutations in the Mononucleotide Repeats of TAF1 and TAF1L Genes in Gastric and Colorectal Cancers with Regional Heterogeneity.	TAF1 TAF1L	6.92e-06	2	92	2	27571988
Pubmed	Striatal Cholinergic Dysregulation after Neonatal Decrease in X-Linked Dystonia Parkinsonism-Related TAF1 Isoforms.	TAF1 TAF1L	6.92e-06	2	92	2	34403156
Pubmed	Insulin and Glucose Alter Death-Associated Protein Kinase 3 (DAPK3) DNA Methylation in Human Skeletal Muscle.	DAPK3 ATP2A3	6.92e-06	2	92	2	28011458
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	SUPT5H BCLAF1 TFIP11 CHD8 TAF1 NOP2 TAF1L	1.06e-05	283	92	7	30585729
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	FNDC3B MAGED1 ZNF608 BCLAF1 ZNF644 EIF4G1 POR PODXL2 TFIP11 CHD8 CHD4 NOP2 SDF2	1.69e-05	1203	92	13	29180619
Pubmed	Expression of matrix metalloproteinases MMP-1, MMP-11 and MMP-19 is correlated with the WHO-grading of human malignant gliomas.	MMP11 MMP19	2.07e-05	3	92	2	17980449
Pubmed	Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC).	ANO2 ANO1	2.07e-05	3	92	2	23576756
Pubmed	TMEM16A and TMEM16B Modulate Pheromone-Evoked Action Potential Firing in Mouse Vomeronasal Sensory Neurons.	ANO2 ANO1	2.07e-05	3	92	2	34433575
Pubmed	Anoctamin Calcium-Activated Chloride Channels May Modulate Inhibitory Transmission in the Cerebellar Cortex.	ANO2 ANO1	2.07e-05	3	92	2	26558388
Pubmed	Regulated expression of TAF1 in 1-cell mouse embryos.	TAF1 TAF1L	2.07e-05	3	92	2	16822332
Pubmed	NRAGE is involved in homologous recombination repair to resist the DNA-damaging chemotherapy and composes a ternary complex with RNF8-BARD1 to promote cell survival in squamous esophageal tumorigenesis.	MAGED1 RNF8	2.07e-05	3	92	2	27035619
Pubmed	Putative pore-loops of TMEM16/anoctamin channels affect channel density in cell membranes.	ANO2 ANO1	2.07e-05	3	92	2	23613533
Pubmed	TAFII55 binding to TAFII250 inhibits its acetyltransferase activity.	TAF1 TAF1L	2.07e-05	3	92	2	11592977
Pubmed	A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure.	RNF8 CHD4	2.07e-05	3	92	2	22531782
Pubmed	Expression patterns of anoctamin 1 and anoctamin 2 chloride channels in the mammalian nose.	ANO2 ANO1	2.07e-05	3	92	2	22314846
Pubmed	Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis.	TAF1 TAF1L	2.07e-05	3	92	2	12217962
Pubmed	TAF7: a possible transcription initiation check-point regulator.	TAF1 TAF1L	2.07e-05	3	92	2	16407123
Pubmed	Ca2+-activated Cl- currents in the murine vomeronasal organ enhance neuronal spiking but are dispensable for male-male aggression.	ANO2 ANO1	2.07e-05	3	92	2	29769308
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	KIF13B TDRD3 MAGED1 SUPT5H ZNF644 NFKB2 RNF8 TOPBP1 BSN	2.65e-05	588	92	9	38580884
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ATG5 VLDLR MAGED1 KDM4C SUPT5H RHOBTB3 EIF4G1 HECTD4 MAP3K10 TFIP11 CHD4 TAF1 PREPL	3.34e-05	1285	92	13	35914814
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	SNX14 TDRD3 SUPT5H PI4KB EIF4G1 POR CLDND1 DAPK3 CHD4 NOP2 EPG5	3.36e-05	925	92	11	28986522
Pubmed	Risk of cerebral venous thrombosis and novel gene polymorphisms of the coagulation and fibrinolytic systems.	TAF1 F5	4.14e-05	4	92	2	16155788
Pubmed	FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products.	ANO2 ANO1	4.14e-05	4	92	2	12739008
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	HDAC11 KDM4C CHD8 CHD4 CDH3	6.30e-05	157	92	5	30186101
Pubmed	Ca2+-activated Cl− currents are dispensable for olfaction.	ANO2 ANO1	6.89e-05	5	92	2	21516098
Pubmed	Proteomic analysis of mouse thymoma EL4 cells treated with bis(tri-n-butyltin)oxide (TBTO).	EIF4G1 CHD4	6.89e-05	5	92	2	19552622
Pubmed	Acetyltransferase p300 collaborates with chromodomain helicase DNA-binding protein 4 (CHD4) to facilitate DNA double-strand break repair.	RNF8 CHD4	6.89e-05	5	92	2	26546801
Pubmed	Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.	PHF20 CHD8 TAF1	7.63e-05	31	92	3	15960975
Pubmed	HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences.	PPP2R3A SOX18 TAF1	8.40e-05	32	92	3	11748221
Pubmed	MDC1 collaborates with TopBP1 in DNA replication checkpoint control.	RNF8 TOPBP1	1.03e-04	6	92	2	21482717
Pubmed	Identification and characterization of TMEM16E and TMEM16F genes in silico.	ANO2 ANO1	1.03e-04	6	92	2	15067359
Pubmed	Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells.	TAF1 TAF1L	1.03e-04	6	92	2	19959467
Pubmed	The functional interactome landscape of the human histone deacetylase family.	HDAC11 BCLAF1 TFIP11 CHD4 NOP2 ATP2A3	1.22e-04	289	92	6	23752268
Pubmed	Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome.	KCNC1 KCNH1	1.44e-04	7	92	2	12060745
Pubmed	The Secreted Glycoprotein Reelin Suppresses the Proliferation and Regulates the Distribution of Oligodendrocyte Progenitor Cells in the Embryonic Neocortex.	VLDLR ADAMTS3	1.44e-04	7	92	2	32913108
Pubmed	ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins.	ANO2 ANO1	1.44e-04	7	92	2	22075693
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	GON4L ALS2 CHD8 EPG5	1.54e-04	101	92	4	10997877
Pubmed	Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.	MAGED1 EIF4G1 CHD8 CHD4	1.54e-04	101	92	4	26949739
Pubmed	Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome.	TAF1 TAF1L	1.92e-04	8	92	2	2034279
Pubmed	The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels.	ANO2 ANO1	1.92e-04	8	92	2	21984732
Pubmed	Physical mapping of 2000 kb of the mouse X chromosome in the vicinity of the Xist locus.	TAF1 TAF1L	1.92e-04	8	92	2	8468051
Pubmed	Expression and function of epithelial anoctamins.	ANO2 ANO1	1.92e-04	8	92	2	20056604
Pubmed	Expression of TMEM16 paralogs during murine embryogenesis.	ANO2 ANO1	1.92e-04	8	92	2	18729231
Pubmed	Genetic mapping in the region of the mouse X-inactivation center.	TAF1 TAF1L	1.92e-04	8	92	2	1974879
Pubmed	Deletion of Prl7d1 causes placental defects at mid-pregnancy in mice.	TAF1 TAF1L	1.92e-04	8	92	2	31012985
Pubmed	High-density molecular map of the central span of the mouse X chromosome.	TAF1 TAF1L	1.92e-04	8	92	2	1675191
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	BCLAF1 ZNF644 EIF4G1 TOPBP1 TFIP11 CHD8 CHD4 TAF1 NOP2 TAF1L	2.18e-04	954	92	10	36373674
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	SFMBT1 PPP2R3A BCLAF1 PI4KB POR PODXL2 CHD4 NOP2 SDK1	2.20e-04	777	92	9	35844135
Pubmed	The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation.	TAF1 TAF1L	2.46e-04	9	92	2	12665565
Pubmed	Cloning and characterization of a new human Xq13 gene, encoding a putative helicase.	TAF1 TAF1L	2.46e-04	9	92	2	7874112
Pubmed	HIV-1 tat binds TAFII250 and represses TAFII250-dependent transcription of major histocompatibility class I genes.	TAF1 TAF1L	2.46e-04	9	92	2	9751712
Pubmed	The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.	SUPT5H BCLAF1 EIF4G1 GON4L CHD4 NOP2	2.51e-04	330	92	6	32529326
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	KIF13B BCLAF1 ZNF644 TFIP11 CHD8 NOP2	2.99e-04	341	92	6	32971831
Pubmed	Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis.	ATG5 EPG5	3.07e-04	10	92	2	26764600
Pubmed	Genetic and molecular evidence of an X-chromosome deletion spanning the tabby (Ta) and testicular feminization (Tfm) loci in the mouse.	TAF1 TAF1L	3.07e-04	10	92	2	2055107
Pubmed	Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels.	ANO2 ANO1	3.07e-04	10	92	2	19015192
Pubmed	Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members.	ANO2 ANO1	3.07e-04	10	92	2	23532839
Pubmed	Structure and function of TMEM16 proteins (anoctamins).	ANO2 ANO1	3.07e-04	10	92	2	24692353
Pubmed	Characterization of a murine gene expressed from the inactive X chromosome.	TAF1 TAF1L	3.75e-04	11	92	2	2034278
Pubmed	An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin.	SOX18 CDH3	3.75e-04	11	92	2	26256211
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CDR2L KIF13B BMX PI4KB EIF4G1 MAP3K10 FNIP1 DAPK3 ALS2	4.66e-04	861	92	9	36931259
Pubmed	New nomenclature for chromatin-modifying enzymes.	KDM4C TAF1 TAF1L	4.73e-04	57	92	3	18022353
Pubmed	Mapping of loci and translocation breakpoints in Xq13: isolation of a conserved locus that maps close to CCG1 in human and mouse.	TAF1 TAF1L	5.30e-04	13	92	2	8012115
Pubmed	Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development.	TAF1 TAF1L	5.30e-04	13	92	2	11557891
Pubmed	Rps4 maps near the inactivation center on the mouse X chromosome.	TAF1 TAF1L	5.30e-04	13	92	2	1740345
Pubmed	XIST and the mapping of the X chromosome inactivation centre.	TAF1 TAF1L	5.30e-04	13	92	2	1772416
Pubmed	The murine interleukin-2 receptor gamma chain gene: organization, chromosomal localization and expression in the adult thymus.	TAF1 TAF1L	5.30e-04	13	92	2	7805729
Pubmed	An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers.	PHF20 KDM4C	6.17e-04	14	92	2	28981838
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SFMBT1 PHF20 SUPT5H BCLAF1 ZNF644 TOPBP1 TFIP11 CHD4 NOP2 TAF1L CREB3L2	6.18e-04	1294	92	11	30804502
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DOC2A CDR2L SEMA4F TDRD3 CASKIN1 NFKB2 EIF4G1 HECTD4 CHD8 ATP2A3	6.88e-04	1105	92	10	35748872
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	SUPT5H GON4L CHD8 CHD4	6.92e-04	150	92	4	28242625
Pubmed	Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines.	KIAA0319 KDM4C	7.11e-04	15	92	2	20923822
Pubmed	The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis.	TAF1 TAF1L	7.11e-04	15	92	2	14580349
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KIAA0319 ZNF644 GON4L FNIP1 ALS2 EPG5	7.57e-04	407	92	6	12693553
Pubmed	Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.	TFIP11 GDF2 SDK1	7.59e-04	67	92	3	20398908
Pubmed	Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis.	SOX18 CDH3	8.11e-04	16	92	2	22115758
Pubmed	Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.	RNF8 TOPBP1	8.11e-04	16	92	2	27760317
Pubmed	A large-scale candidate gene association study of age at menarche and age at natural menopause.	GABRB2 NFKB2 GDF2 F5 CHRNE	8.37e-04	275	92	5	20734064
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	SFMBT1 ZNF608 ZNF644 CHD8 CHD4 TAF1	8.69e-04	418	92	6	34709266
Pubmed	The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer.	PI4KB EIF4G1 CHD4	8.99e-04	71	92	3	29346117
Pubmed	Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.	BSN CDH3	9.17e-04	17	92	2	19915572
Pubmed	A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.	GVINP1 IFFO1 BCLAF1 IPO13 CHD8	9.66e-04	284	92	5	29459677
Pubmed	Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.	GABRB2 KCNC1	1.03e-03	18	92	2	37321992
Pubmed	Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.	SFMBT1 CHD4 TAF1	1.05e-03	75	92	3	25593309
Pubmed	Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria.	VLDLR TAF1 TAF1L	1.10e-03	76	92	3	22323595
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	SUPT5H BCLAF1 HECTD4 CHD8 CHD4 NOP2	1.13e-03	440	92	6	34244565
Pubmed	Lost in transcription: molecular mechanisms that control HIV latency.	SUPT5H TAF1	1.15e-03	19	92	2	23518577
GeneFamily	Tudor domain containing	TDRD3 PHF20 KDM4C	2.62e-04	37	61	3	780
GeneFamily	Anoctamins	ANO2 ANO1	4.95e-04	10	61	2	865
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP11 MMP19	2.95e-03	24	61	2	891
GeneFamily	Sterile alpha motif domain containing	SFMBT1 ASZ1 CASKIN1	3.27e-03	88	61	3	760
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF13B BMX CASKIN1 TRPC3 SOX18 ATP2A3	2.44e-06	186	92	6	4ae3c0fe8640a8d029875cf3f0f5ffbba38e85f8
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-11\|TCGA-Brain / Sample_Type by Project: Shred V9	BMX MMP19 ATP2A3 SDK1 SBK3	6.69e-06	127	92	5	7c3f8c791567fff5d2f42c2c7d09c78ec6ca3afe
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMX GVINP1 TRPC3 SOX18 ATP2A3	2.98e-05	173	92	5	a2c1ef3f4d7e9f68fc77ee7c42a4727bdea5da94
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Endothelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMX GVINP1 TRPC3 SOX18 ATP2A3	2.98e-05	173	92	5	4830136f1f1976e00ac9af9062a531ac42533041
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Endothelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMX GVINP1 TRPC3 SOX18 ATP2A3	2.98e-05	173	92	5	0b79e2a4fd19d524c24b69a6b524ffc6affdabe5
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPP2R3A ADAMTS3 RHOBTB3 SORCS2 SDK1	3.69e-05	181	92	5	aa233b652921848af2257cc3687a7a09c3acfb67
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS3 KCNH1 MMP19 CDH3 SDK1	3.69e-05	181	92	5	7af469f5bcb9b1ab3f35b2758bf2afb87e8eba57
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-stromal_related-ICC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANO2 STC2 ANO1 PODXL2 UBE2U	3.89e-05	183	92	5	262387ee8d43b96e5f1a77c75124459a506a6172
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-stromal_related\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANO2 STC2 ANO1 PODXL2 UBE2U	3.89e-05	183	92	5	c85a707acbcb582912e8ac080a36d05f91cfd7a2
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF13B ZNF608 IFFO1 SOX18 TFIP11	4.21e-05	186	92	5	37860daeecd6d412bd3797f30496a56da667fbd1
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF608 TRPC3 ANO1 ATP11C SDK1	4.21e-05	186	92	5	77592a6397b44b2b59a4fc39d7224dd95343efe6
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF13B ZNF608 IFFO1 SOX18 TFIP11	4.21e-05	186	92	5	60830822d3de3147816693404fd03392e04c2b8e
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF13B ZNF608 IFFO1 SOX18 TFIP11	4.21e-05	186	92	5	baebeffdd426ce767190ddefc857cc78e6a58d36
ToppCell	facs-Aorta-Heart-3m-Mesenchymal\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VLDLR MAGED1 POR PODXL2 CDH3	4.89e-05	192	92	5	0dc1f46e40346ed0b286e53b106a812441575100
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRB2 KCNC1 PHYHIP PODXL2 BSN	5.01e-05	193	92	5	5fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FNDC3B DPP4 RGL3 CDH3 SDK1	5.26e-05	195	92	5	938b31dbf1674ee6fd0123bc88391ddcaf151217
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FNDC3B DPP4 RGL3 CDH3 SDK1	5.26e-05	195	92	5	d39e9e6544f49e677ebe528c6fe60b99a3630e30
ToppCell	Bronchial-10x5prime-Stromal-Mesofibroblastic-Mesothelia\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	GABRB2 DPP4 VLDLR PHYHIP UBE2U	5.52e-05	197	92	5	26888af95a7cc082a1f1218af35b1f07cb9436ed
ToppCell	Bronchial-10x5prime-Stromal-Mesofibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	GABRB2 DPP4 VLDLR PHYHIP UBE2U	5.52e-05	197	92	5	438de7f0d35d81d5f5e41dcef7b2c54b6da03df4
ToppCell	Neuronal-Inhibitory-iA-iA_2(LAMP5)-CA1-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZNF608 TRPC3 ANO1 ATP11C SDK1	5.93e-05	200	92	5	ca5401b76ab014080914bf78042d368cf318effa
ToppCell	Neuronal-Inhibitory-iA-iA_2(LAMP5)-CA1--L2-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZNF608 TRPC3 ANO1 ATP11C SDK1	5.93e-05	200	92	5	70c47d3bbe67d88c5b9dff99c33a603d25fa2ab0
ToppCell	Neuronal-Inhibitory-iA\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZNF608 TRPC3 ANO1 ATP11C SDK1	5.93e-05	200	92	5	5ef4a3dc18a44292184a59ced916183c0699b01e
ToppCell	Neuronal-Inhibitory-iA-iA_2(LAMP5)-CA1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZNF608 TRPC3 ANO1 ATP11C SDK1	5.93e-05	200	92	5	40286010bd17cf9e34ecd5440953b072ebfae208
Disease	Hepatic fibrosis	SORCS2 CDH3 SDK1	4.14e-04	49	87	3	HP_0001395
Disease	tea consumption measurement	KDM4C HECTD4 PHYHIP POR	5.86e-04	129	87	4	EFO_0010091
Disease	interferon gamma measurement, platelet-derived growth factor BB measurement, interleukin 4 measurement, interleukin 10 measurement, stromal cell-derived factor 1 alpha measurement, interleukin-6 measurement, interleukin 12 measurement, interleukin 17 measurement, vascular endothelial growth factor measurement, fibroblast growth factor basic measurement, granulocyte colony-stimulating factor measurement	VLDLR F5	1.00e-03	16	87	2	EFO_0004750, EFO_0004753, EFO_0004762, EFO_0004810, EFO_0008130, EFO_0008142, EFO_0008165, EFO_0008174, EFO_0008184, EFO_0008264, EFO_0008293
Disease	synophrys measurement	ATG5 ZNF608 ANO1	1.08e-03	68	87	3	EFO_0007906
Disease	Congenital Myasthenic Syndromes, Postsynaptic	AK9 PREPL	1.14e-03	17	87	2	C0751883
Disease	chemokine (C-C motif) ligand 27 measurement	KDM4C TAF1L F5	1.18e-03	70	87	3	EFO_0008082
Disease	interleukin 10 measurement	VLDLR SORCS2 FNIP1	1.61e-03	78	87	3	EFO_0004750
Disease	Intellectual Disability	GABRB2 SNX14 GON4L CHD8 TAF1 PREPL	2.10e-03	447	87	6	C3714756
Disease	response to radiation	KIAA0319 KDM4C EPG5	2.27e-03	88	87	3	GO_0009314
Disease	inflammatory biomarker measurement	VLDLR F5	2.67e-03	26	87	2	EFO_0004872

Protein segments in the cluster

Peptide	Gene	Start	Entry
GSWLENVESYLEEFD	EPG5	266	Q9HCE0
YEDSTWELKEDVDEG	CHD8	756	Q9HCK8
GMEDFSAEEEESWYD	CDR2L	6	Q86X02
DGSRFQVWDYEEGEV	DNPH1	136	O43598
EDDTIYEGEFSDDWT	ALS2	1216	Q96Q42
EEEENLDDYDWFAGN	BMX	286	P51813
EQVYDWSTGLEDTDD	EFL1	206	Q7Z2Z2
AVNGEEWYETDDFVI	GVINP1	2316	Q7Z2Y8
EWGTEDDEYLDKVER	HDAC11	226	Q96DB2
DFDSWGQLVEAIDEY	AIDA	21	Q96BJ3
LGYFWDLTGIEEEEE	ANO2	466	Q9NQ90
RQEDISEIWFEYEGT	ATG5	61	Q9H1Y0
AWFEEGEETTTAFVE	ATP2A3	76	Q93084
ESSESEDDGWEIGYL	ASZ1	16	Q8WWH4
KIDIDTEAYTENGEW	CHRNE	191	Q04844
VIYDVLDGTDAWDSA	GDF2	171	Q9UK05
QYFWEEEEELNDSSL	PODXL2	96	Q9NZ53
GYENIDFITDITWED	CASKIN1	566	Q8WXD9
WTAVFDYEAAGDEEL	MAP3K10	21	Q02779
EFELLTWDEEGDFGD	MAGED1	711	Q9Y5V3
DFYDWLQETDVDLSG	POR	151	P16435
SEAYHLGQEETDWFD	BSN	3571	Q9UPA5
DEDEFWTEGTYRGVN	MMP19	191	Q99542
EEKEAWYREESDSLG	DAPK3	361	O43293
ADINGSIYDEGVDEW	KDM4C	136	Q9H3R0
IWYSIGDYEIFDEDT	KCNH1	396	O95259
EEGWYEEALEQFEEI	LRP2BP	71	Q9P2M1
EDIIYNGITDWVYEE	DPP4	191	P27487
DDIEFYWRGDDNAVT	GABRB2	186	P47870
YRWDLTGFEEEEEAV	ANO1	436	Q5XXA6
EFDIWYNESFVIPED	KIF9	701	Q9HAQ2
WEGGDEEDISLTAYV	OVOS2	1076	Q6IE36
WEIEIVSYGDTDDDT	HECTD4	1996	Q9Y4D8
DWGEETEDGAVYSVS	RGL3	16	Q3MIN7
WDRFAAEEYETLVAE	PPP2R3A	1086	Q06190
ETEETLLLWEDFSGY	IFFO1	426	Q0D2I5
TFIDLGVEWDYNIED	ADAMTS3	776	O15072
GVEWDYNIEDDIESL	ADAMTS3	781	O15072
LYEEELAFWGIDETD	KCNC1	86	P48547
WNEDLTYSGITDDDI	DOC2A	156	Q14183
TTGSVEWLEEDEHYD	PRMT7	11	Q9NVM4
DISEYRLEWGEDEES	FNDC3B	796	Q53EP0
SYYGGEQEDWAEEDE	FNIP1	961	Q8TF40
AEGEWEDQEALDYFS	BCLAF1	371	Q9NYF8
DFEEINWTEEKEYEF	GON4L	1786	Q3T8J9
NWTEEKEYEFDGFEE	GON4L	1791	Q3T8J9
DEDVVKEDAFYSWES	EIF4G1	1551	Q04637
RQGDDEQSDWFYEGE	GPATCH2L	241	Q9NWQ4
QASWESEDVEIQDYD	CHD4	651	Q14839
AIGDEEEWVTLYEEE	SDK1	1111	Q7Z5N4
YEDREEGGSSLEEWT	SBK3	326	P0C264
DEEYGFWSSDEKEQF	IPO13	406	O94829
SGQERYEASDLTWEE	NPM2	116	Q86SE8
DSDIYWTAEVNEEGD	CDH3	586	P22223
DWTDYDEKAQESVGI	CZIB	136	Q9NWV4
SDSFNDDEVESEKWY	CREB3L2	101	Q70SY1
DDEVESEKWYLSTDF	CREB3L2	106	Q70SY1
FIYSGAFQWEELEED	RHOBTB3	346	O94955
FLWSDDEYGQDVDVT	PHF20	621	Q9BVI0
VHFDYDETWTIGDDQ	MMP11	191	P24347
WDATLTGEEEEEFFE	KIF13B	1196	Q9NQT8
VDGDYVVSEWSEIIE	PHYHIPL	141	Q96FC7
FQYTAWELTGEDYEE	AK9	881	Q5TCS8
WELTGEDYEEETEDY	AK9	886	Q5TCS8
GLWDTYEDDISEISQ	SULT2B1	11	O00204
EAWEEEGTYDQTLEF	TDRD3	611	Q9H7E2
AEWGDEDGDDEIYFF	SEMA4F	236	O95754
ENAEYEYEVTEEDWE	RNF8	116	O76064
WDYSEFVQRETDIED	F5	1591	P12259
DEGWIRSTEDAVDYS	TAF1L	96	Q8IZX4
NDEGWVRSTEDAVDY	TAF1	96	P21675
EEDYSSWELSNLQGD	SORCS2	651	Q96PQ0
DGEYLVSGWSETVEF	PHYHIP	96	Q92561
YEDEDQWEDGAEDIL	SUPT5H	86	O00267
LWGSEDDADTVDDYG	NOP2	131	P46087
NYDNDDEAWSVDDIG	PI4KB	451	Q9UBF8
FGEEGEGDYLDDWTV	SDF2	121	Q99470
WDEFISDEADEKTYN	CLDND1	51	Q9NY35
FISWDKDFYDEEINE	ATP11C	376	Q8NB49
EEDEYETSGEGQDIW	TDP1	141	Q9NUW8
DDTVNWYSSSEEEEG	ZC3H6	696	P61129
PWYRDVTDDESFVDE	SNX14	151	Q9Y5W7
GSSEWEDEQSEYSDI	STC2	286	O76061
EWVKDEEDEDVLFYT	PREPL	206	Q4J6C6
DIYETEEEGWKSDTS	UBE2U	276	Q5VVX9
EEEGWKSDTSLYEND	UBE2U	281	Q5VVX9
DSYETEDESSWDNVE	ZNF644	851	Q9H582
EDESSWDNVELGDYT	ZNF644	856	Q9H582
TVDTYDSGDDWEIGV	ZNF608	16	Q9ULD9
EEVELSWEDYLEETG	SFMBT1	16	Q9UHJ3
ADLWADVDLTEFDQY	SOX18	316	P35713
FDDVALYFSEQEWEI	ZNF425	11	Q6IV72
EEDYEWGSSSILDVL	TOPBP1	1346	Q92547
KEEATYGVWAERDSD	TFIP11	46	Q9UBB9
SYQEIEDDSDVEWKF	TRPC3	661	Q13507
TIFEDRVYWIDGENE	VLDLR	651	P98155
DDTEIVSYHWEEING	KIAA0319	461	Q5VV43
DDIEVRFYEDDENGW	NFKB2	256	Q00653