Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	GTPase activator activity	ARHGEF19 MYO9A BCR ANKRD27 TBC1D26 ARHGAP29 ARHGAP25 ARHGAP18 ACAP2 ACAP3	1.07e-04	279	164	10	GO:0005096
GeneOntologyMolecularFunction	nuclear receptor binding	MED16 PRAMEF15 PRAMEF4 TRIP12 MMS19 CNOT1 MED13 PRAMEF11	1.60e-04	187	164	8	GO:0016922
GeneOntologyBiologicalProcess	macroautophagy	VPS39 MTMR8 SREBF2 RNF213 PLEKHM1 PIK3R4 SNX14 AP5Z1 ZFYVE26 WDFY3 FKBP8 LRBA UVRAG	9.05e-06	374	163	13	GO:0016236
GeneOntologyBiologicalProcess	process utilizing autophagic mechanism	VPS39 UBR4 MTMR8 SREBF2 RNF213 WDFY4 PLEKHM1 FBXL4 PIK3R4 SNX14 AP5Z1 ZFYVE26 WDFY3 FKBP8 LRBA UVRAG PLK3	1.62e-05	650	163	17	GO:0061919
GeneOntologyBiologicalProcess	autophagy	VPS39 UBR4 MTMR8 SREBF2 RNF213 WDFY4 PLEKHM1 FBXL4 PIK3R4 SNX14 AP5Z1 ZFYVE26 WDFY3 FKBP8 LRBA UVRAG PLK3	1.62e-05	650	163	17	GO:0006914
GeneOntologyBiologicalProcess	double-strand break repair	DPF1 RAD51B EPC2 ZNF365 FANCD2 FANCB AP5Z1 ZFYVE26 PRKDC ZSWIM7 UVRAG	5.58e-05	324	163	11	GO:0006302
GeneOntologyBiologicalProcess	regulation of GTPase activity	MKKS ARHGEF19 MYO9A RICTOR BCR TBC1D26 ARHGAP29 FGD1 RIPOR1 ARHGAP25 FGD3	7.52e-05	335	163	11	GO:0043087
GeneOntologyCellularComponent	transferase complex	CCNI2 EPC2 PRAMEF9 PRAMEF15 FBXW4 CUL9 ZYG11B PRAMEF4 STT3A FBXL4 PIK3R4 KAT7 FBXL7 RPAP1 UBR3 MMS19 PRKDC FBXO39 SUZ12 WDFY3 UVRAG MED13 PRAMEF11	2.37e-06	963	166	23	GO:1990234
GeneOntologyCellularComponent	cullin-RING ubiquitin ligase complex	PRAMEF9 PRAMEF15 FBXW4 CUL9 ZYG11B PRAMEF4 FBXL4 FBXL7 FBXO39 PRAMEF11	7.82e-06	212	166	10	GO:0031461
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	PRAMEF9 PRAMEF15 ZYG11B PRAMEF4 PRAMEF11	3.48e-05	47	166	5	GO:0031462
GeneOntologyCellularComponent	endosome	PPP1R21 VPS39 UBR4 EQTN LY96 ATP9A STEAP2 PMEPA1 WDFY4 ANKRD27 ADCY5 PLEKHM1 PIK3R4 JAK3 USP6 SNX14 AP5Z1 VPS35L ZFYVE26 C1orf210 ACAP2 UVRAG DOP1B	5.16e-05	1167	166	23	GO:0005768
GeneOntologyCellularComponent	intracellular protein-containing complex	EPC2 PRAMEF9 PRAMEF15 FBXW4 CUL9 RICTOR ZYG11B PRAMEF4 DICER1 FBXL4 KAT7 MALT1 FBXL7 RPAP1 UBR3 MMS19 PRKDC FBXO39 CNOT1 PRAMEF11	9.29e-05	972	166	20	GO:0140535
GeneOntologyCellularComponent	ubiquitin ligase complex	PRAMEF9 PRAMEF15 FBXW4 CUL9 ZYG11B PRAMEF4 FBXL4 FBXL7 UBR3 FBXO39 PRAMEF11	1.22e-04	352	166	11	GO:0000151
GeneOntologyCellularComponent	DNA-dependent protein kinase complex	PRKDC UVRAG	6.17e-04	5	166	2	GO:0070418
Domain	ARM-type_fold	IFT172 UBR4 CUL9 RICTOR ZYG11B TRIP12 WDFY4 PIK3R4 NBEAL2 RIPOR1 MMS19 PRKDC WDFY3 LRBA EIF3M IPO11	4.44e-08	339	162	16	IPR016024
Domain	-	CUL9 RICTOR ZYG11B TRIP12 WDFY4 PIK3R4 AP5Z1 RIPOR1 MMS19 PRKDC WDFY3 LRBA IPO11	7.25e-08	222	162	13	1.25.10.10
Domain	ARM-like	CUL9 RICTOR ZYG11B TRIP12 WDFY4 PIK3R4 NBEAL2 AP5Z1 RIPOR1 MMS19 PRKDC WDFY3 LRBA IPO11	1.02e-07	270	162	14	IPR011989
Domain	AlbA_2	SLFN5 SLFN14 SLFN13 SLFN11	1.87e-07	7	162	4	PF04326
Domain	Schlafen	SLFN5 SLFN14 SLFN13 SLFN11	1.87e-07	7	162	4	IPR029684
Domain	Schlafen_AAA_dom	SLFN5 SLFN14 SLFN13 SLFN11	1.87e-07	7	162	4	IPR007421
Domain	PH-BEACH_dom	WDFY4 NBEAL2 WDFY3 LRBA	3.72e-07	8	162	4	IPR023362
Domain	-	WDFY4 NBEAL2 WDFY3 LRBA	3.72e-07	8	162	4	2.30.29.40
Domain	PH_BEACH	WDFY4 NBEAL2 WDFY3 LRBA	3.72e-07	8	162	4	PS51783
Domain	DUF2075	SLFN5 SLFN13 SLFN11	6.41e-07	3	162	3	PF09848
Domain	DUF2075	SLFN5 SLFN13 SLFN11	6.41e-07	3	162	3	IPR018647
Domain	BEACH	WDFY4 NBEAL2 WDFY3 LRBA	6.64e-07	9	162	4	PS50197
Domain	Beach	WDFY4 NBEAL2 WDFY3 LRBA	6.64e-07	9	162	4	PF02138
Domain	-	WDFY4 NBEAL2 WDFY3 LRBA	6.64e-07	9	162	4	1.10.1540.10
Domain	Beach	WDFY4 NBEAL2 WDFY3 LRBA	6.64e-07	9	162	4	SM01026
Domain	BEACH_dom	WDFY4 NBEAL2 WDFY3 LRBA	6.64e-07	9	162	4	IPR000409
Domain	PH_dom-like	ARHGEF19 FRMPD1 MTMR8 BCR WDFY4 PLEKHM1 JAK3 NBEAL2 FGD1 ARHGAP25 WDFY3 LRBA ACAP2 FRMD5 ACAP3 FGD3	9.68e-07	426	162	16	IPR011993
Domain	WD40_repeat_dom	KNTC1 COPA FBXW9 MED16 IFT172 KIF21A UBR4 FBXW4 WDFY4 PIK3R4 NBEAL2 WDFY3 LRBA	2.00e-06	297	162	13	IPR017986
Domain	WD_REPEATS_1	COPA FBXW9 MED16 IFT172 KIF21A FBXW4 WDFY4 PIK3R4 NBAS NBEAL2 WDFY3 LRBA	5.78e-06	278	162	12	PS00678
Domain	WD_REPEATS_2	COPA FBXW9 MED16 IFT172 KIF21A FBXW4 WDFY4 PIK3R4 NBAS NBEAL2 WDFY3 LRBA	6.00e-06	279	162	12	PS50082
Domain	WD_REPEATS_REGION	COPA FBXW9 MED16 IFT172 KIF21A FBXW4 WDFY4 PIK3R4 NBAS NBEAL2 WDFY3 LRBA	6.00e-06	279	162	12	PS50294
Domain	DUF4704	NBEAL2 WDFY3 LRBA	6.32e-06	5	162	3	IPR031570
Domain	DUF4704	NBEAL2 WDFY3 LRBA	6.32e-06	5	162	3	PF15787
Domain	PH_BEACH	NBEAL2 WDFY3 LRBA	1.26e-05	6	162	3	PF14844
Domain	WD40	COPA FBXW9 MED16 IFT172 KIF21A FBXW4 WDFY4 PIK3R4 NBEAL2 WDFY3 LRBA	1.67e-05	259	162	11	PF00400
Domain	WD40	COPA FBXW9 MED16 IFT172 KIF21A FBXW4 WDFY4 PIK3R4 NBEAL2 WDFY3 LRBA	2.29e-05	268	162	11	SM00320
Domain	F-box	FBXW9 FBXW4 FBXO47 FBXL4 FBXL7 FBXO39	2.50e-05	67	162	6	PF00646
Domain	WD40_repeat	COPA FBXW9 MED16 IFT172 KIF21A FBXW4 WDFY4 PIK3R4 NBEAL2 WDFY3 LRBA	2.62e-05	272	162	11	IPR001680
Domain	-	COPA FBXW9 MED16 IFT172 KIF21A FBXW4 WDFY4 PIK3R4 NBAS NBEAL2 WDFY3 LRBA	3.49e-05	333	162	12	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	COPA FBXW9 MED16 IFT172 KIF21A FBXW4 WDFY4 PIK3R4 NBAS NBEAL2 WDFY3 LRBA	3.70e-05	335	162	12	IPR015943
Domain	FBOX	FBXW9 FBXW4 FBXO47 FBXL4 FBXL7 FBXO39	3.78e-05	72	162	6	PS50181
Domain	F-box_dom	FBXW9 FBXW4 FBXO47 FBXL4 FBXL7 FBXO39	4.77e-05	75	162	6	IPR001810
Domain	Med13_N	MED13L MED13	7.48e-05	2	162	2	PF11597
Domain	Mediator_Med13_N_met/fun	MED13L MED13	7.48e-05	2	162	2	IPR021643
Domain	Med13_C	MED13L MED13	7.48e-05	2	162	2	PF06333
Domain	Mediator_Med13	MED13L MED13	7.48e-05	2	162	2	IPR009401
Domain	FBOX	FBXW9 FBXW4 FBXL4 FBXL7 FBXO39	8.63e-05	52	162	5	SM00256
Domain	FYVE	FGD1 ZFYVE26 WDFY3 FGD3	1.09e-04	29	162	4	PF01363
Domain	FYVE	FGD1 ZFYVE26 WDFY3 FGD3	1.09e-04	29	162	4	SM00064
Domain	-	PRAMEF25 PRAMEF15 LRRC10 NLRP1 ZYG11B PRAMEF4 FBXL4 FBXL7 FBXO39 LRRD1 NLRP13	1.16e-04	321	162	11	3.80.10.10
Domain	L_dom-like	PRAMEF25 PRAMEF15 LRRC10 NLRP1 ZYG11B PRAMEF4 FBXL4 FBXL7 FBXO39 LRRD1 NLRP13	1.40e-04	328	162	11	IPR032675
Domain	RhoGAP	MYO9A BCR ARHGAP29 ARHGAP25 ARHGAP18	2.00e-04	62	162	5	SM00324
Domain	Znf_FYVE-rel	FGD1 ZFYVE26 WDFY3 FGD3	2.06e-04	34	162	4	IPR017455
Domain	RhoGAP	MYO9A BCR ARHGAP29 ARHGAP25 ARHGAP18	2.16e-04	63	162	5	PF00620
Domain	RhoGAP_dom	MYO9A BCR ARHGAP29 ARHGAP25 ARHGAP18	2.33e-04	64	162	5	IPR000198
Domain	RHOGAP	MYO9A BCR ARHGAP29 ARHGAP25 ARHGAP18	2.33e-04	64	162	5	PS50238
Domain	-	MYO9A BCR ARHGAP29 ARHGAP25 ARHGAP18	2.33e-04	64	162	5	1.10.555.10
Domain	Znf_FYVE	FGD1 ZFYVE26 WDFY3 FGD3	3.20e-04	38	162	4	IPR000306
Domain	ZF_FYVE	FGD1 ZFYVE26 WDFY3 FGD3	3.91e-04	40	162	4	PS50178
Domain	PRAME_family	PRAMEF25 PRAMEF15 PRAMEF4	5.60e-04	19	162	3	IPR026271
Domain	F-box-like	FBXW9 FBXW4 FBXL7 FBXO39	5.65e-04	44	162	4	PF12937
Domain	Rho_GTPase_activation_prot	MYO9A BCR ARHGAP29 ARHGAP25 ARHGAP18	1.01e-03	88	162	5	IPR008936
Domain	LIPASE_GDXG_SER	AADACL4 AADACL3	1.10e-03	6	162	2	PS01174
Domain	LIPASE_GDXG_HIS	AADACL4 AADACL3	1.10e-03	6	162	2	PS01173
Domain	AB_hydrolase_3	AADACL4 AADACL3	1.53e-03	7	162	2	IPR013094
Domain	ZnF_UBR1	UBR4 UBR3	1.53e-03	7	162	2	SM00396
Domain	Abhydrolase_3	AADACL4 AADACL3	1.53e-03	7	162	2	PF07859
Domain	ZF_UBR	UBR4 UBR3	1.53e-03	7	162	2	PS51157
Domain	zf-UBR	UBR4 UBR3	1.53e-03	7	162	2	PF02207
Domain	Znf_UBR	UBR4 UBR3	1.53e-03	7	162	2	IPR003126
Domain	HEAT	PIK3R4 MMS19 PRKDC IPO11	1.61e-03	58	162	4	IPR000357
Domain	-	ARHGEF19 MTMR8 BCR PLEKHM1 FGD1 ARHGAP25 ACAP2 FRMD5 ACAP3 FGD3	2.23e-03	391	162	10	2.30.29.30
Domain	Leu-rich_rpt	LRRC10 NLRP1 ZYG11B FBXL4 FBXL7 FBXO39 LRRD1 NLRP13	2.56e-03	271	162	8	IPR001611
Domain	RhoGEF	ARHGEF19 BCR FGD1 FGD3	2.89e-03	68	162	4	SM00325
Domain	PH	ARHGEF19 BCR PLEKHM1 FGD1 ARHGAP25 ACAP2 ACAP3 FGD3	3.00e-03	278	162	8	SM00233
Domain	PH_DOMAIN	ARHGEF19 BCR PLEKHM1 FGD1 ARHGAP25 ACAP2 ACAP3 FGD3	3.06e-03	279	162	8	PS50003
Domain	WD40_repeat_CS	COPA FBXW9 KIF21A WDFY4 PIK3R4 WDFY3	3.10e-03	164	162	6	IPR019775
Domain	PH_domain	ARHGEF19 BCR PLEKHM1 FGD1 ARHGAP25 ACAP2 ACAP3 FGD3	3.13e-03	280	162	8	IPR001849
Domain	TPR_REGION	SH3TC2 IFT172 DNAH2 TMTC2 PRKDC FKBP8	3.20e-03	165	162	6	PS50293
Domain	TPR	SH3TC2 IFT172 DNAH2 TMTC2 PRKDC FKBP8	3.20e-03	165	162	6	PS50005
Domain	RhoGEF	ARHGEF19 BCR FGD1 FGD3	3.21e-03	70	162	4	PF00621
Domain	HEAT_REPEAT	PIK3R4 MMS19 PRKDC IPO11	3.21e-03	70	162	4	PS50077
Domain	DH_2	ARHGEF19 BCR FGD1 FGD3	3.21e-03	70	162	4	PS50010
Domain	-	ARHGEF19 BCR FGD1 FGD3	3.37e-03	71	162	4	1.20.900.10
Domain	DH-domain	ARHGEF19 BCR FGD1 FGD3	3.37e-03	71	162	4	IPR000219
Domain	GROEL-like_equatorial	MKKS BBS10	6.35e-03	14	162	2	IPR027413
Domain	-	MKKS BBS10	6.35e-03	14	162	2	1.10.560.10
Domain	GroEL-like_apical_dom	MKKS BBS10	7.29e-03	15	162	2	IPR027409
Domain	Cpn60/TCP-1	MKKS BBS10	7.29e-03	15	162	2	IPR002423
Domain	Cpn60_TCP1	MKKS BBS10	7.29e-03	15	162	2	PF00118
Domain	-	MKKS BBS10	7.29e-03	15	162	2	3.50.7.10
Domain	HEAT	PIK3R4 MMS19 PRKDC	8.33e-03	48	162	3	PF02985
Pubmed	Schlafen, a new family of growth regulatory genes that affect thymocyte development.	SLFN5 SLFN14 SLFN13 SLFN11	7.82e-09	6	168	4	9846487
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	EPC2 GGNBP2 VPS39 UBR4 SREBF2 RICTOR MED13L DICER1 FBXL4 FANCD2 KAT7 NBAS SMG8 SNX14 INTS2 MCUR1 CPSF1 SLFN11 SUZ12 STRA6 CNOT1 EIF3M MED13 ZNF292	2.82e-08	1327	168	24	32694731
Pubmed	Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence.	SLFN5 SLFN14 SLFN13 SLFN11	3.62e-08	8	168	4	19619625
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	SREBF2 ATP9A RETSAT ANKRD27 PLEKHM1 PIK3R4 NBAS SNX14 VPS35L FKBP8 LRBA FAM135A UVRAG DOP1B	1.85e-07	504	168	14	34432599
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ARHGEF19 VPS39 UBR4 MTMR8 CUL9 MED13L BCR PLEKHM1 JAK3 RPAP1 NBEAL2 CPSF1 RIPOR1 ZFYVE26 PRKDC WDFY3 LRBA UVRAG PLK3 MED13	4.41e-07	1105	168	20	35748872
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	KNTC1 COPA RICTOR TRIP12 DICER1 NBAS MMS19 PRKDC CNOT1	6.71e-07	202	168	9	33005030
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	IFT172 FRMPD1 CUL9 ZYG11B MED13L ATP9A ZNF365 RPAP1 RIPOR1 SUZ12 TMEM181 DOP1B	7.69e-07	407	168	12	12693553
Pubmed	Defining the membrane proteome of NK cells.	PPP1R21 COPA MED16 UBR4 RNF213 RETSAT BCR ANKRD27 STT3A PIK3R4 NBAS INTS2 NBEAL2 MMS19 PRKDC FKBP8 LRBA ACAP2 CNOT1 MED13	1.04e-06	1168	168	20	19946888
Pubmed	Subcellular localization of the Schlafen protein family.	SLFN5 SLFN13 SLFN11	1.10e-06	5	168	3	18355440
Pubmed	Expression and regulatory effects of murine Schlafen (Slfn) genes in malignant melanoma and renal cell carcinoma.	SLFN5 SLFN13 SLFN11	1.10e-06	5	168	3	24089532
Pubmed	Schlafen-8 is essential for lymphatic endothelial cell activation in experimental autoimmune encephalomyelitis.	SLFN5 SLFN13 SLFN11	1.10e-06	5	168	3	29528433
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	VPS39 KIF21A BCR DICER1 ANKRD27 FBXL7 INTS2 NBEAL2 AP5Z1 ACAP2 CNOT1 MED13 ACAP3	2.00e-06	529	168	13	14621295
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	DPF1 EPC2 RBL1 CUL9 RNF213 RICTOR CLSTN2 BCR DICER1 FANCD2 KAT7 MALT1 BMPR1A MMS19 SLFN11 SUZ12 WDFY3 FKBP8 PCCA	2.15e-06	1116	168	19	31753913
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	KIF21A UBR4 DNAH2 RNF213 PCARE SLFN5 TRIP12 FBXL7 RPAP1 MCUR1 CPSF1 PRKDC CNOT1 BANK1 DOP1B	3.22e-06	736	168	15	29676528
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	VPS39 SLFN5 MMS19 SLFN11 PRKDC LRBA CNOT1	3.30e-06	129	168	7	23022380
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	GGNBP2 C12orf56 ORC3 RBL1 SREBF2 RICTOR BCR DICER1 ANKRD27 PIK3R4 SMG8 RPAP1 FKBP8 CMTR2	3.70e-06	650	168	14	38777146
Pubmed	Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.	FBXW9 FBXW4 RNF213 TRIP12 FBXL4 FBXL7	3.71e-06	85	168	6	19028597
Pubmed	The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development.	MED16 MED13L MED13	3.82e-06	7	168	3	12093747
Pubmed	Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif.	SLFN5 SLFN13 SLFN11	3.82e-06	7	168	3	15351786
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	MRPS27 TRIP12 NSUN7 PIK3R4 SNX14 NBEAL2 CPSF1 FKBP8 LRBA CNOT1 IPO11 ZNF292	6.00e-06	497	168	12	36774506
Pubmed	Spatacsin regulates directionality of lysosome trafficking by promoting the degradation of its partner AP5Z1.	UBR4 AP5Z1 ZFYVE26	6.09e-06	8	168	3	37871017
Pubmed	Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	FRMPD1 NLRP1 DICER1 WDFY3 CNOT1 DOP1B	1.07e-05	102	168	6	10231032
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	RAD51B MYO9A FRMPD1 SREBF2 EVC RNF213 CHD1L STEAP2 BCR PLEKHM1 STT3A MALT1 INTS2 TTLL11 VPS35L RIPOR1 LRBA PCCA CNOT1 TMEM181 EIF3M	1.12e-05	1489	168	21	28611215
Pubmed	Systematic analysis and nomenclature of mammalian F-box proteins.	FBXW9 FBXW4 FBXL4 FBXL7 FBXO39	1.18e-05	61	168	5	15520277
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	SREBF2 CHD1L MED13L PMEPA1 DICER1 USP6 BMPR1A SLC25A52 SUZ12 WDFY3 MED13 IPO11	1.28e-05	536	168	12	15840001
Pubmed	Real-time resolution of point mutations that cause phenovariance in mice.	JAK3 MALT1 PRKDC	1.30e-05	10	168	3	25605905
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	C12orf56 PRAMEF15 PRAMEF4 PRAMEF11	1.31e-05	30	168	4	38786026
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	SREBF2 CHD1L MED13L PMEPA1 DICER1 USP6 BMPR1A SLC25A52 SUZ12 WDFY3 MED13 IPO11	1.32e-05	538	168	12	10512203
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	COPA VPS39 IFT172 KIF21A UBR4 FBXW4 CUL9 MED13L TRIP12 ZNF365 PIK3R4 VPS35L PRKDC WDFY3 LRBA ZNF439 MED13 DOP1B ZNF292	1.58e-05	1285	168	19	35914814
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	VPS39 RNF213 STEAP2 PMEPA1 DICER1 STT3A FANCD2 BMPR1A INTS2 SLC25A52 PRKDC WDFY3 FKBP8 LRBA STRA6 PCCA IPO11	1.66e-05	1061	168	17	33845483
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	CCDC14 EPC2 MED16 CHD1L MED13L TRIP12 KAT7 SUZ12 LRBA ACAP2 CNOT1 EIF3M MED13	1.67e-05	645	168	13	25281560
Pubmed	cDNA cloning and expression analysis of new members of the mammalian F-box protein family.	FBXW4 FBXL4 FBXL7	1.78e-05	11	168	3	10945468
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	PPP1R21 COPA VPS39 RBL1 DNAH2 BCR STT3A FBXL7 SCMH1 CPSF1 RIPOR1 FKBP8 ACAP2 EIF3M	1.95e-05	754	168	14	35906200
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	COPA UBR4 STT3A FANCD2 RPAP1 INTS2 MMS19 PRKDC FKBP8 ACAP2 CNOT1 EIF3M IPO11	2.03e-05	657	168	13	36180527
Pubmed	Targeting an Achilles' heel of cancer with a WRN helicase inhibitor.	FANCD2 PRKDC	2.32e-05	2	168	2	24036544
Pubmed	HIV protease inhibitor Lopinavir induces apoptosis of primary effusion lymphoma cells via suppression of NF-κB pathway.	JAK3 PRKDC	2.32e-05	2	168	2	24012878
Pubmed	Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia.	JAK3 SUZ12	2.32e-05	2	168	2	31492675
Pubmed	Impaired mitochondrial dynamics underlie axonal defects in hereditary spastic paraplegias.	AP5Z1 ZFYVE26	2.32e-05	2	168	2	29726929
Pubmed	Mediator complex component MED13 regulates zygotic genome activation and is required for postimplantation development in the mouse.	MED13L MED13	2.32e-05	2	168	2	29325037
Pubmed	The SCID mouse: an experimental model for endometriosis.	MKKS PRKDC	2.32e-05	2	168	2	10601104
Pubmed	Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response.	SLFN13 SLFN11	2.32e-05	2	168	2	37833372
Pubmed	Fancd2 functions in a double strand break repair pathway that is distinct from non-homologous end joining.	FANCD2 PRKDC	2.32e-05	2	168	2	16135554
Pubmed	Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.	SLFN13 SLFN11	2.32e-05	2	168	2	29563550
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	COPA VPS39 UBR4 CUL9 BCR FANCD2 BMPR1A CPSF1 MMS19	2.34e-05	313	168	9	38270169
Pubmed	Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover.	DICER1 FBXL4 FBXL7 MMS19	2.74e-05	36	168	4	24035498
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	PPP1R21 COPA MYO9A UBR4 SREBF2 TRIP12 FBXL7 MMS19 PRKDC	2.92e-05	322	168	9	26514267
Pubmed	mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.	VPS39 PIK3R4 UVRAG	3.06e-05	13	168	3	25533187
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	COPA RBL1 UBR4 ATP9A RETSAT STT3A SNX14 VKORC1 ZMYND10 FKBP8 TMEM181	3.40e-05	499	168	11	22810586
Pubmed	Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.	KNTC1 EPC2 COPA KIF21A FBXW4 NLRP1 MMS19 SUZ12	3.83e-05	257	168	8	30945288
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	COPA UBR4 DNAH2 SREBF2 ATP9A TRIP12 STT3A FANCD2 VKORC1 RPAP1 LMBR1L MMS19 PRKDC FKBP8 IPO11	5.71e-05	942	168	15	31073040
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	GGNBP2 ORC3 UBR4 DNAH2 LRRC10 MRPS27 HSPA12B USP6 VKORC1 SLFN11 WDFY3 CNOT1	6.90e-05	638	168	12	31182584
Pubmed	Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo.	RBL1 DICER1	6.94e-05	3	168	2	20019750
Pubmed	Truncation and microdeletion of EVC/EVC2 with missense mutation of EFCAB7 in Ellis-van Creveld syndrome.	EVC EFCAB7	6.94e-05	3	168	2	26748586
Pubmed	MicroRNAs of the miR-290-295 Family Maintain Bivalency in Mouse Embryonic Stem Cells.	DICER1 SUZ12	6.94e-05	3	168	2	27150236
Pubmed	Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA.	SLFN13 SLFN11	6.94e-05	3	168	2	38875319
Pubmed	Cross-species genomic and epigenomic landscape of retinoblastoma.	RBL1 PRKDC	6.94e-05	3	168	2	23765217
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF15 PRAMEF4 PRAMEF11	7.16e-05	17	168	3	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF15 PRAMEF4 PRAMEF11	7.16e-05	17	168	3	37781892
Pubmed	Genetic variations strongly influence phenotypic outcome in the mouse retina.	RBL1 RETSAT ZNF365 SCMH1	7.32e-05	46	168	4	21779340
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	VPS39 PRAMEF15 FRMPD1 SREBF2 RICTOR PRAMEF4 TRIP12 WDFY4 KAT7 BMPR1A INTS2 VPS35L CNOT1 FAM135A TMEM181 PRAMEF11	7.83e-05	1084	168	16	11544199
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF15 PRAMEF4 PRAMEF11	8.56e-05	18	168	3	23894331
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF15 PRAMEF4 PRAMEF11	8.56e-05	18	168	3	39181896
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF15 PRAMEF4 PRAMEF11	8.56e-05	18	168	3	12890732
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF15 PRAMEF4 PRAMEF11	8.56e-05	18	168	3	29731491
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF15 PRAMEF4 PRAMEF11	8.56e-05	18	168	3	14675769
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	UBR4 CUL9 RNF213 TRIP12 UBR3	1.01e-04	95	168	5	29643511
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF15 PRAMEF4 PRAMEF11	1.01e-04	19	168	3	28604677
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF15 PRAMEF4 PRAMEF11	1.19e-04	20	168	3	26694250
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF15 PRAMEF4 PRAMEF11	1.19e-04	20	168	3	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF15 PRAMEF4 PRAMEF11	1.19e-04	20	168	3	21425410
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	COPA MED16 ORC3 UBR4 RNF213 CHD1L MED13L FANCD2 KAT7 CPSF1 MMS19 PRKDC SUZ12 EIF3M MED13	1.29e-04	1014	168	15	32416067
Pubmed	Mutation spectrum in BBS genes guided by homozygosity mapping in an Indian cohort.	MKKS BBS10	1.38e-04	4	168	2	24400638
Pubmed	EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia.	EVC EFCAB7	1.38e-04	4	168	2	24582806
Pubmed	Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models.	KAT7 PRKDC	1.38e-04	4	168	2	39321266
Pubmed	High incidence of HPV-associated head and neck cancers in FA deficient mice is associated with E7's induction of DNA damage through its inactivation of pocket proteins.	RBL1 FANCD2	1.38e-04	4	168	2	24086435
Pubmed	Reversal of autoimmunity by boosting memory-like autoregulatory T cells.	PRKDC G6PC2	1.38e-04	4	168	2	20381385
Pubmed	High incidence of female reproductive tract cancers in FA-deficient HPV16-transgenic mice correlates with E7's induction of DNA damage response, an activity mediated by E7's inactivation of pocket proteins.	RBL1 FANCD2	1.38e-04	4	168	2	24013229
Pubmed	Bcr/Abl interferes with the Fanconi anemia/BRCA pathway: implications in the chromosomal instability of chronic myeloid leukemia cells.	BCR FANCD2	1.38e-04	4	168	2	21203397
Pubmed	Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4H.	FGD1 FGD3	1.38e-04	4	168	2	17564959
Pubmed	Clinical and genetic characterization of Bardet-Biedl syndrome in Tunisia: defining a strategy for molecular diagnosis.	MKKS BBS10	1.38e-04	4	168	2	23432027
Pubmed	FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment.	MED13L MED13	1.38e-04	4	168	2	29809150
Pubmed	Mutations in chaperonin-like BBS genes are a major contributor to disease development in a multiethnic Bardet-Biedl syndrome patient population.	MKKS BBS10	1.38e-04	4	168	2	20472660
Pubmed	ACAP3 regulates neurite outgrowth through its GAP activity specific to Arf6 in mouse hippocampal neurons.	ACAP2 ACAP3	1.38e-04	4	168	2	27330119
Pubmed	Novel insights into FGD3, a putative GEF for Cdc42, that undergoes SCF(FWD1/beta-TrCP)-mediated proteasomal degradation analogous to that of its homologue FGD1 but regulates cell morphology and motility differently from FGD1.	FGD1 FGD3	1.38e-04	4	168	2	18363964
Pubmed	Sequence variants in four genes underlying Bardet-Biedl syndrome in consanguineous families.	MKKS BBS10	1.38e-04	4	168	2	28761321
Pubmed	Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG.	PIK3R4 UVRAG	1.38e-04	4	168	2	16799551
Pubmed	mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes.	RICTOR PRKDC	1.38e-04	4	168	2	16221682
Pubmed	Isolation, characterization, and mapping of the mouse Fgd3 gene, a new Faciogenital Dysplasia (FGD1; Aarskog Syndrome) gene homologue.	FGD1 FGD3	1.38e-04	4	168	2	10721717
Pubmed	Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.	MKKS IFT172 PCARE DICER1 BBS10 CXCR5 STRA6	1.47e-04	233	168	7	32290105
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KNTC1 SH3TC2 MRPS27 RNF213 RICTOR WDFY4 LMBR1L UBR3 ARHGAP25 FAM135A	1.53e-04	493	168	10	15368895
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF15 PRAMEF4 PRAMEF11	1.59e-04	22	168	3	31729367
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF15 PRAMEF4 PRAMEF11	1.83e-04	23	168	3	19480014
Pubmed	An abundance of X-linked genes expressed in spermatogonia.	PRAMEF15 PRAMEF4 USP26 PRAMEF11	1.94e-04	59	168	4	11279525
Pubmed	A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia.	AP5Z1 ZFYVE26	2.30e-04	5	168	2	20613862
Pubmed	Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy.	PIK3R4 UVRAG	2.30e-04	5	168	2	23878393
Pubmed	Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader.	PIK3R4 UVRAG	2.30e-04	5	168	2	30978004
Pubmed	SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion.	ATP9A DOP1B	2.30e-04	5	168	2	30213940
Pubmed	Expanding antigen-specific regulatory networks to treat autoimmunity.	PRKDC G6PC2	2.30e-04	5	168	2	26886799
Pubmed	Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex.	PIK3R4 UVRAG	2.30e-04	5	168	2	25490155
Pubmed	Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery.	KNTC1 NBAS	2.30e-04	5	168	2	20462495
Interaction	OPALIN interactions	KNTC1 MED16 RNF213 SLFN5 FANCD2 BMPR1A INTS2 PRKDC WDFY3 FRMD5 IPO11 DOP1B	6.92e-08	209	153	12	int:OPALIN
Interaction	TMEM9B interactions	SREBF2 RNF213 RETSAT NBAS BMPR1A INTS2 FKBP8 FRMD5 IPO11	1.73e-07	111	153	9	int:TMEM9B
Interaction	FPR1 interactions	KNTC1 RNF213 FANCD2 INTS2 AP5Z1 PRKDC WDFY3 PCCA IPO11 DOP1B	1.85e-07	147	153	10	int:FPR1
Interaction	GPR182 interactions	KNTC1 ORC3 SREBF2 RNF213 RETSAT FANCD2 PIK3R4 SNX14 RPAP1 NBEAL2 AP5Z1 MMS19 PRKDC WDFY3 IPO11 DOP1B	3.95e-07	455	153	16	int:GPR182
Interaction	GPR17 interactions	KNTC1 RNF213 CHD1L FANCD2 PIK3R4 NBAS INTS2 UBR3 PRKDC WDFY3 LRBA IPO11	1.77e-06	283	153	12	int:GPR17
Interaction	NPTN interactions	KNTC1 RNF213 FANCD2 SMG8 LMBR1L NBEAL2 AP5Z1 ZFYVE26 MMS19 IPO11 DOP1B	9.34e-06	278	153	11	int:NPTN
Interaction	EEF1AKMT3 interactions	KNTC1 CUL9 RICTOR CHD1L SLFN5 TRIP12 ANKRD27 SMG8 RPAP1 NBEAL2 ARHGAP29 FKBP8	2.27e-05	364	153	12	int:EEF1AKMT3
Interaction	LRRC31 interactions	KNTC1 COPA RICTOR TRIP12 DICER1 NBAS MMS19 PRKDC CNOT1	2.76e-05	205	153	9	int:LRRC31
Interaction	TRIM66 interactions	CUL9 RNF213 RICTOR BCR FANCD2 BMPR1A MMS19 SLFN11 WDFY3	2.76e-05	205	153	9	int:TRIM66
Interaction	TRRAP interactions	PPP1R21 EPC2 MED16 VPS39 RBL1 DNAH2 SREBF2 BCR STT3A FANCD2 FBXL7 SCMH1 RIPOR1 SLFN11 SUZ12 FKBP8 ACAP2 MED13	3.21e-05	790	153	18	int:TRRAP
Interaction	FAM234A interactions	KNTC1 INTS2 LMBR1L PRKDC C1orf210 WDFY3 IPO11	5.03e-05	126	153	7	int:FAM234A
Interaction	XRCC3 interactions	RAD51B COPA MED16 UBR4 PIK3R4 MMS19 FKBP8 ZSWIM7	7.13e-05	180	153	8	int:XRCC3
Cytoband	1p36.21	PRAMEF25 PRAMEF9 AADACL4 AADACL3 PRAMEF15 PRAMEF4 PRAMEF11	3.46e-09	63	167	7	1p36.21
Cytoband	17q12	GGNBP2 SLFN5 SLFN14 FBXO47 SLFN13 SLFN11	1.79e-06	99	167	6	17q12
Cytoband	Ensembl 112 genes in cytogenetic band chr17q12	GGNBP2 SLFN5 SLFN14 FBXO47 SLFN13 SLFN11	1.89e-05	149	167	6	chr17q12
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	ARHGEF19 PRAMEF25 PRAMEF9 AADACL4 AADACL3 UBR4 PRAMEF15 PRAMEF4 PRAMEF11 ACAP3	2.13e-04	681	167	10	chr1p36
GeneFamily	Schlafen family	SLFN5 SLFN14 SLFN13 SLFN11	7.50e-08	7	125	4	1110
GeneFamily	WD repeat domain containing\|BEACH domain containing	WDFY4 NBEAL2 WDFY3 LRBA	2.67e-07	9	125	4	1230
GeneFamily	PRAME family	PRAMEF25 PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF11	5.58e-07	24	125	5	686
GeneFamily	WD repeat domain containing	COPA FBXW9 MED16 IFT172 KIF21A FBXW4 WDFY4 PIK3R4 NBEAL2 WDFY3 LRBA	2.07e-06	262	125	11	362
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	FGD1 ZFYVE26 WDFY3 FGD3	5.93e-05	31	125	4	81
GeneFamily	Lipases\|Arylacetamide deacetylase family	AADACL4 AADACL3	2.82e-04	4	125	2	465
GeneFamily	Bardet-Biedl syndrome associated\|BBSome	MKKS IFT172 BBS10	3.92e-04	21	125	3	980
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	BCR PLEKHM1 FGD1 ARHGAP25 ACAP2 ACAP3 FGD3	5.77e-04	206	125	7	682
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR4 UBR3	9.73e-04	7	125	2	785
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF19 BCR FGD1 FGD3	1.13e-03	66	125	4	722
GeneFamily	Cyclins\|Mediator complex	MED16 MED13L MED13	1.51e-03	33	125	3	1061
GeneFamily	Taste 2 receptors	TAS2R38 TAS2R36 TAS2R20	2.46e-03	39	125	3	1162
GeneFamily	WD repeat domain containing\|F-box and WD repeat domain containing	FBXW9 FBXW4	2.50e-03	11	125	2	559
GeneFamily	Chaperonins	MKKS BBS10	4.69e-03	15	125	2	587
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP29 ARHGAP25 ARHGAP18	4.99e-03	50	125	3	721
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	ACAP2 ACAP3	6.03e-03	17	125	2	1291
GeneFamily	Ring finger proteins\|Fanconi anemia complementation groups\|Protein phosphatase 1 regulatory subunits\|BRCA1 A complex\|BRCA1 B complex\|BRCA1 C complex	FANCD2 FANCB	8.30e-03	20	125	2	548
GeneFamily	F-box and leucine rich repeat proteins	FBXL4 FBXL7	9.14e-03	21	125	2	558
Coexpression	GSE27786_LSK_VS_MONO_MAC_UP	CUL9 RETSAT BBS10 SCMH1 CPSF1 PRKDC ARHGAP18 ZSWIM7 FAM135A IPO11	4.50e-07	200	160	10	M4763
Coexpression	GSE18791_CTRL_VS_NEWCASTLE_VIRUS_DC_2H_UP	PAQR8 FBXL4 FANCB SMG8 FUT11 ZFYVE26 EFCAB7 CMTR2 FRMD5	3.61e-06	197	160	9	M4257
Coexpression	GSE27786_BCELL_VS_NKTCELL_DN	CUL9 RETSAT TRIP12 ADCY5 CPSF1 MMS19 PRKDC ARHGAP18 PCCA	4.09e-06	200	160	9	M4809
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	MED13L TRIP12 DICER1 PIK3R4 USP6 NBAS MALT1 BMPR1A FBXL7 ARHGAP29 SUZ12 WDFY3 ACAP2 PCCA UVRAG MED13 DOP1B ZNF292	5.29e-06	856	160	18	M4500
Coexpression	GSE32423_MEMORY_VS_NAIVE_CD8_TCELL_IL7_UP	VPS39 CXCR5 BMPR1A ARHGAP18 TMEM181 BANK1 FRMD5 DOP1B	3.31e-05	200	160	8	M5074
Coexpression	GSE10240_CTRL_VS_IL17_STIM_PRIMARY_BRONCHIAL_EPITHELIAL_CELLS_UP	FBXW4 PCARE CLSTN2 HSPA12B BCR ADCY5 BBS10 UVRAG	3.31e-05	200	160	8	M300
Coexpression	GSE20198_UNTREATED_VS_IL12_TREATED_ACT_CD4_TCELL_DN	EPC2 PAQR8 FBXW4 BCR ADCY5 SLC37A2 RIPOR1 ADGRE1	3.31e-05	200	160	8	M7361
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC14 KNTC1 MYO9A WDFY4 PLEKHM1 NSUN7 FANCB TMEM65 ADGRE1 TMEM181 BANK1	3.11e-11	163	167	11	8dc0128eeede933537e3bcc5d6ec0322711552f3
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC14 KNTC1 MYO9A WDFY4 PLEKHM1 NSUN7 FANCB TMEM65 ADGRE1 TMEM181 BANK1	3.11e-11	163	167	11	fd243ca223079033be480a24817a399f281fa4d4
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	CCDC14 KNTC1 RNF213 NBAS PRKDC LRBA DOP1B ZNF292	5.30e-07	186	167	8	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	RAD51B MYO9A TMTC2 MED13L SCMH1 WDFY3 LRBA PCCA	8.50e-07	198	167	8	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	RAD51B MED13L NBAS SCMH1 UBR3 WDFY3 LRBA PCCA	8.83e-07	199	167	8	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	KNTC1 RNF213 NBAS PRKDC LRBA DOP1B ZNF292	6.45e-06	185	167	7	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	KNTC1 RNF213 NBAS PRKDC LRBA DOP1B ZNF292	7.95e-06	191	167	7	9454f642c3621370fa23640b631301346b300950
ToppCell	RV-08._Macrophage\|World / Chamber and Cluster_Paper	TBXAS1 RNF213 LY96 WDFY4 ARHGAP25 ARHGAP18 FGD3	8.22e-06	192	167	7	a1b5dc5beb97a23729b97b54fb4574d10d8fbfb3
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	RAD51B MYO9A TMTC2 MED13L SCMH1 LRBA PCCA	9.40e-06	196	167	7	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	healthy_donor-Lymphocytic-T_cell-CD8+_Memory_T_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	KIF21A RNF213 SLFN5 BCR FUT11 ARHGAP25 TMEM181	9.40e-06	196	167	7	af00c31612e4fe068e5fccae05368edba46bbd20
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-Dividing_AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KNTC1 SH3TC2 RBL1 EVC FANCD2 FANCB SLFN13	1.07e-05	200	167	7	af3dc76b4507bf4edd265169f5dfbbb8a19eb394
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_D2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	KNTC1 TMEM247 ATP9A ZNF546 NBAS ARHGAP29	2.37e-05	152	167	6	595afcfa8b161e291fcaf2afc7336bac9b6fae0f
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PPP1R21 TBXAS1 KNTC1 GPR160 SLC37A2 ADGRE1	3.05e-05	159	167	6	c0e55f25271f788c08fa4b95186501fc27b2ec39
ToppCell	droplet-Marrow-BM-30m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3TC2 UBR4 SLFN5 AP5Z1 LRBA ADGRE1	3.39e-05	162	167	6	75df7ff779a3b9159ba97d852da1f8df650b9ce5
Disease	Abnormality of the respiratory system	PPP1R21 SUZ12	2.78e-05	2	156	2	C4018871
Disease	Neurodevelopmental Disorders	MED13L TRIP12 ADCY5 WDFY3 ZNF292	1.38e-04	93	156	5	C1535926
Disease	X-linked Aarskog syndrome (implicated_via_orthology)	FGD1 FGD3	1.65e-04	4	156	2	DOID:6683 (implicated_via_orthology)
Disease	response to non-steroidal anti-inflammatory, drug-induced liver injury	RAD51B TBXAS1	1.65e-04	4	156	2	EFO_0004228, EFO_0005533
Disease	Charcot-Marie-Tooth disease type 4H (implicated_via_orthology)	FGD1 FGD3	1.65e-04	4	156	2	DOID:0110192 (implicated_via_orthology)
Disease	Chediak-Higashi syndrome (implicated_via_orthology)	WDFY4 WDFY3	1.65e-04	4	156	2	DOID:2935 (implicated_via_orthology)
Disease	Charcot-Marie-Tooth disease (implicated_via_orthology)	MTMR8 FGD1 FGD3	2.70e-04	24	156	3	DOID:10595 (implicated_via_orthology)
Disease	Attention deficit hyperactivity disorder	FGD1 MED13 ZNF292	2.70e-04	24	156	3	C1263846
Disease	Urogenital Abnormalities	FGD1 SUZ12	5.73e-04	7	156	2	C0042063
Disease	Malignant neoplasm of breast	RAD51B TBXAS1 VPS39 UBR4 FRMPD1 MTMR8 SREBF2 ZNF365 ZNF546 PIK3R4 CXCR5 ARHGAP29 ZFYVE26 LRBA EIF3M	5.98e-04	1074	156	15	C0006142
Disease	Abnormality of the skeletal system	SUZ12 ZNF292	7.62e-04	8	156	2	C4021790
Disease	post-traumatic stress disorder symptom measurement	RAD51B SLFN14 ADCY5 PLEKHM1	9.54e-04	82	156	4	EFO_0008535
Disease	urticaria, response to non-steroidal anti-inflammatory, angioedema	RAD51B BANK1	9.76e-04	9	156	2	EFO_0005531, EFO_0005532, EFO_0005533
Disease	abdominal aortic calcification measurement	GPR160 PIK3R4	1.22e-03	10	156	2	EFO_0010272
Disease	C-C motif chemokine 16 measurement	SLFN5 SLFN11	1.77e-03	12	156	2	EFO_0008044
Disease	Bardet-Biedl Syndrome	IFT172 BBS10	2.08e-03	13	156	2	C0752166
Disease	total cholesterol measurement, triglyceride measurement, low density lipoprotein cholesterol measurement, high density lipoprotein cholesterol measurement	ADCY5 RPAP1 BANK1	2.23e-03	49	156	3	EFO_0004530, EFO_0004574, EFO_0004611, EFO_0004612
Disease	Bardet-Biedl syndrome (is_implicated_in)	MKKS BBS10	2.42e-03	14	156	2	DOID:1935 (is_implicated_in)
Disease	Fanconi anemia	FANCD2 FANCB	2.42e-03	14	156	2	cv:C0015625
Disease	body weights and measures, parental genotype effect measurement	ADCY5 NLRP13	2.42e-03	14	156	2	EFO_0004324, EFO_0005939
Disease	Ciliopathies	MKKS EVC PCARE BBS10	2.81e-03	110	156	4	C4277690
Disease	Cardiovascular Abnormalities	STRA6 ZNF292	3.17e-03	16	156	2	C0243050
Disease	behavioural inhibitory control measurement	TTLL11 STRA6	3.17e-03	16	156	2	EFO_0008467
Disease	Polydactyly	MKKS IFT172 EVC BBS10	3.51e-03	117	156	4	C0152427
Disease	Bardet-Biedl syndrome 1 (disorder)	MKKS BBS10	3.59e-03	17	156	2	C2936862
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	MED13 ZNF292	3.59e-03	17	156	2	DOID:0060307 (is_implicated_in)
Disease	information processing speed, response to cranial radiation therapy	CUL9 HSPA12B ARHGAP25	3.61e-03	58	156	3	EFO_0004363, EFO_0010950
Disease	atrial fibrillation	LRRC10 LY96 GJA8 SCMH1 PCCA BANK1 ZNF292	3.70e-03	371	156	7	EFO_0000275
Disease	Bone marrow hypocellularity	FANCD2 FANCB	4.02e-03	18	156	2	C1855710
Disease	Bardet-Biedl syndrome	MKKS BBS10	4.02e-03	18	156	2	cv:C0752166
Disease	rheumatoid arthritis, ACPA-positive rheumatoid arthritis, rheumatoid factor seropositivity measurement	RAD51B WDFY4 CXCR5	4.56e-03	63	156	3	EFO_0000685, EFO_0007791, EFO_0009459
Disease	white matter microstructure measurement	OR14J1 PLEKHM1 FBXL7 C1orf210 SUZ12 WDFY3 BANK1	4.84e-03	390	156	7	EFO_0005674
Disease	Severe Combined Immunodeficiency	JAK3 PRKDC	4.96e-03	20	156	2	C0085110

Protein segments in the cluster

Peptide	Gene	Start	Entry
ILIVHLKRYSLNEFC	USP26	516	Q9BXU7
SFRHLELLNLTSYKC	BANK1	66	Q8NDB2
ADLDKLRYRHCLTTL	EPC2	426	Q52LR7
ILKRCSTLLGHISLF	BPIFB3	156	P59826
IALHKVNFYCSSLLL	CXCR5	126	P32302
RHVFLFTDLLLCTKL	BCR	726	P11274
LCLRHLKEKASAYIT	DPF1	371	Q92782
YLHCATITSLRLAAK	CCNI2	191	Q6ZMN8
TYQRLFLDCLLHSLR	CMTR2	621	Q8IYT2
ALTLTRKCFRHLALD	ACAP3	156	Q96P50
RKCFRHLALDYVLQI	ACAP3	161	Q96P50
AKLRFLHCIFLYLVT	AADACL4	41	Q5VUY2
SFLYRSLSCLKALHG	AP5Z1	341	O43299
ATRKCFRHIALDYVL	ACAP2	161	Q15057
CLVATIHFLKSLDAY	AADACL3	166	Q5VUY0
YLKEHSIETFLILRC	ADCY5	631	O95622
SILYRLHCLLTAEEL	DICER1	1056	Q9UPY3
LYVHNCRLVFLLRKD	CLSTN2	416	Q9H4D0
LRSKRYVHLGLISTC	BBS10	376	Q8TAM1
DLLKCIQTYLSLFRS	CCDC14	346	Q49A88
LLTSSKVHLYRELTC	RAD51B	171	O15315
LDASRLLLYSSQICK	JAK3	921	P52333
YLHLFNDCLLLSRRK	ARHGEF19	621	Q8IW93
LYTKCLQQLLRDSHL	ANKRD27	181	Q96NW4
LAHLSCASIKINIIY	OR52E2	186	Q8NGJ4
CSYLDARLVLHVLSR	FBXW9	91	Q5XUX1
LCLLAKLFLDHKTLY	KAT7	421	O95251
VIRLNKHLLSLCISY	MKKS	116	Q9NPJ1
KHLLSLCISYLKSET	MKKS	121	Q9NPJ1
KLLIFSEHFCSLINL	LRRD1	521	A4D1F6
SEHFCSLINLKYLDL	LRRD1	526	A4D1F6
VSLLSHCLVALNRYL	GPR88	126	Q9GZN0
SRKLYFDTHALVCLL	MCUR1	161	Q96AQ8
YECRTLLFKAIHNLL	MED13L	116	Q71F56
HCLYTRLSSLQKLKE	MALT1	666	Q9UDY8
CLLETLETYLRKHRF	GGNBP2	201	Q9H3C7
SDLVCHEVYISLLKL	MTMR8	86	Q96EF0
TKALVLRYHPLSSCL	MMS19	806	Q96T76
LILYLSACKFLDTAL	DOP1B	2146	Q9Y3R5
TLTEICRRLVSHYFL	IPO11	361	Q9UI26
KHTLLRLLYEALVDC	EIF3M	161	Q7L2H7
HKLDLLLGFYSRCLR	KCNQ4	631	P56696
ESRICKALFLYTSHL	DDX58	531	O95786
LLIALAAKCHLCRRY	C1orf210	46	Q8IVY1
HQSKVITLCLYRDLS	CPSF1	691	Q10570
HYTLCATLLLAFKGL	FAM135A	241	Q9P2D6
LKHLSLLDLCFISVT	OR14J1	61	Q9UGF5
KISLAISFRCLGLHL	OR51S1	151	Q8NGJ8
LESLHCLYETRNKTF	NLRP1	716	Q9C000
EELHLLIISCRKLFY	FBXO39	356	Q8N4B4
HVVKASALLRLYCAL	INTS2	381	Q9H0H0
LSHTIILKNLCVELY	PRAMEF15	401	P0DUQ1
SRAVLELCLAFSKYL	LRBA	541	P50851
ITLHRKYNCKLALSD	KNTC1	696	P50748
LHVCSFRELVKLYLS	LRRC10	46	Q5BKY1
LSLACYIASLVFLHE	ATP9A	986	O75110
TYVKRLHLLDQVFCT	FGD3	171	Q5JSP0
CVVILYSLKTHSLEA	OR4C13	216	Q8NGP0
LRTLKHVLYYSRQCL	PCCA	31	P05165
HFYAECRALSKRLAL	PPP1R21	691	Q6ZMI0
ASVYCRKLRLHQLLD	HSPA12B	246	Q96MM6
ISLTKQLHCYNERLL	NBAS	1626	A2RRP1
DACRLYATKHLRVLL	RICTOR	726	Q6R327
VVITCLLSHYKLSAR	PMEPA1	56	Q969W9
KLRLHLYDIESCSKT	IFT172	506	Q9UG01
VTRVCDYHTKLFLIA	MED16	541	Q9Y2X0
HSLLYILLMARLSFC	OR1K1	156	Q8NGR3
ILCSYTHIAAAILKI	OR10A2	201	Q9H208
LLERYLACKQRSHSL	PANX3	191	Q96QZ0
CFSSFRELRQHLLLK	FANCB	401	Q8NB91
DFVLLSIRFTKYHIC	GPR160	81	Q9UJ42
LVRKILSHDACYFSR	OR5P2	301	Q8WZ92
TYLTCSLLAHLLQSK	PAQR8	121	Q8TEZ7
SHDICDVLKLYLRQL	ARHGAP29	736	Q52LW3
SLCLLFAKLVSYTFL	SLC37A2	301	Q8TED4
LLCKTSDAALLAAYI	FRMD5	126	Q7Z6J6
SQLKLDHYRAALRSC	FKBP8	281	Q14318
CILHTDLYKFLTKRG	EFCAB7	121	A8K855
HIAKLCSLKRLVLYR	FBXL4	421	Q9UKA2
AKLESRLRYLSIAHC	FBXL7	346	Q9UJT9
KLRRCLFTLLGHLDY	COPA	81	P53621
YHDLSVKLLARQCTA	FRMPD1	1546	Q5SYB0
LSRYKFHLALENAIC	FUT11	271	Q495W5
TLLRTYICHIIFKTL	GJA8	146	P48165
FHVLLTTYEICLKDA	CHD1L	146	Q86WJ1
LDTRALLKLAYSAAC	BMPR1A	326	P36894
CALTSLTILQLYHFL	G6PC2	296	Q9NQR9
VYCLRLTTKHLYAAL	FBXW4	386	P57775
CIELKRSKGLLHIFY	LY96	51	Q9Y6Y9
LEHYRSLGLLFKRCT	FBXO47	111	Q5MNV8
VRLTQHLSLLCEKYS	KCNMB3	231	Q9NPA1
LFSLVKRYLCVTSLL	CUL9	256	Q8IWT3
LCIYSLHLKDLLHLD	EVC	211	P57679
VLLAFCSATLYKLRH	EQTN	196	Q9NQ60
LHKFLACLTDTRYKL	DNAH2	201	Q9P225
ILICLASRAKQHLYI	SLFN13	881	Q68D06
LCIYLEHTESILKAI	FANCD2	1186	Q9BXW9
LHSSLSKYEAILCII	PCARE	191	A6NGG8
IAYKLHLECSRLINL	ORC3	631	Q9UBD5
HQEKLQCLSLLYLFS	SMG8	191	Q8ND04
YIFSLSLEALKCFRI	PLEKHM1	701	Q9Y4G2
LLCSSAILKRNLYSD	RETSAT	581	Q6NUM9
LSLYVLFHCLAKKTD	MRPS27	181	Q92552
TLISFLLLIYSLCKH	TAS2R20	191	P59543
TLISFLLLIYSLCKH	TAS2R36	191	P0DTE0
ACLSLLYCSKLIRFS	TAS2R38	111	P59533
LYCSKLIRFSHTFLI	TAS2R38	116	P59533
LCRLHTYLDTLFCLT	TAAR5	106	O14804
LLDTYFTLHLCSTEK	UVRAG	61	Q9P2Y5
KLCFASRAIKHLYLL	SLFN14	891	P0C7P3
ATLYILCHIFLTRFK	LMBR1L	31	Q6UX01
IKRLLYTHLLCIFSI	PIGF	6	Q07326
YHLASVRLRDLCLKL	RBL1	796	P28749
KDRHLDQLLLCAFYI	RBL1	836	P28749
LCIALLSSYSIHLLL	SLC38A5	86	Q8WUX1
ALARCRIKHDALSIY	NSUN7	171	Q8NE18
LSTRLLLHYSPQACK	NBEAL2	841	Q6ZNJ1
KAYVSRLHLLDQVFC	FGD1	386	P98174
LSHTIILKNLCLELY	PRAMEF25	401	A6NGN4
LCQIHAFVDYLRSKL	STT3A	276	P46977
VLICLASRAKQHLYI	SLFN11	881	Q7Z7L1
QRALCLILSKVYLEH	SH3TC2	756	Q8TF17
FAKSLTIRLIRCGYH	STEAP2	41	Q8NFT2
LYEDLSCLLRKHVRA	SLC25A52	101	Q3SY17
YHRDLSRITAILLLC	TBC1D26	186	Q86UD7
LSYECRTLLFKAVHN	MED13	111	Q9UHV7
LYHACLASLSILVLL	STRA6	51	Q9BX79
NSITYVLRFLEKLCH	SCMH1	441	Q96GD3
YLHLHLCVCLLLAKT	ADGRE1	636	Q14246
QFYILKSCLRHSRTL	C12orf56	561	Q8IXR9
KCYHNLDAFVRLIAL	CNOT1	1931	A5YKK6
YCDSKLAALELILHL	PIK3R4	391	Q99570
LSHTIILKNLCVELY	PRAMEF4	401	O60810
LHEAICSSTKLLKFY	RNF213	851	Q63HN8
YIFLELCSRKSLAHI	PLK3	136	Q9H4B4
SQACDLLLAHLKRYA	TBXAS1	156	P24557
VASLIDLCEYHLSLL	TTLL11	731	Q8NHH1
YSLLDICLNFLTTHL	ZYG11B	16	Q9C0D3
EKIRIYTCVLHLLSA	VPS35L	816	Q7Z3J2
HSYEERTLLTKCSLF	ZNF365	51	Q70YC5
LSLDAVYHCLNRTIL	WDFY3	2086	Q8IZQ1
CLTGLVLSLYALHVK	VKORC1	16	Q9BQB6
RKSDSILCKHLLAVY	ZSWIM7	96	Q19AV6
LCLSAASLLLNRYIH	SNX14	36	Q9Y5W7
YLLFLIVRACSELRH	TMEM181	471	Q9P2C4
ACTLTEARYLLDHFL	KIF21A	1031	Q7Z4S6
HYLFCIAAILLCLIK	TMEM247	201	A6NEH6
YSLLKHLKLCHSRFI	SUZ12	461	Q15022
LSHTIILKNLCVELY	PRAMEF9	401	P0DUQ2
SLLSYICRFLHEIQL	ARHGAP25	286	P42331
SHKSYRPLCTLSFRL	TMTC2	61	Q8N394
LFFLLSLLCYIKHCS	TMTC2	146	Q8N394
SCEFSSALEYLKLLH	SREBF2	831	Q12772
KAFICGYQLTLHLRT	ZNF546	476	Q86UE3
RCRQLSLLTKTVYHI	ZNF292	316	O60281
HASTTVLALKLLLYF	WDFY4	1636	Q6ZS81
LSHTIILKNLCLELY	PRAMEF11	401	O60813
IAAHALLLYLRCAQK	TMEM44	41	Q2T9K0
LLLTKERYISCLFSA	POPDC2	221	Q9HBU9
YLTHELLLSCVFRLE	RPAP1	996	Q9BWH6
KVCHLALIELTALYD	ARHGAP18	286	Q8N392
YKDELLASCLTFLLS	PRKDC	721	P78527
IYSLHSTERSCLLKE	TMEM65	76	Q6PI78
HCKTLHIVLFTLLYK	UBR3	921	Q6ZT12
RFILHYQDLCTKLTF	ZBED9	391	Q6R2W3
DLVDYCHRKLTLLVA	ZMYND10	136	O75800
HKCLRAILRIIYFAD	TRIP12	856	Q14669
GRHLLTVLLKLFSYC	UBR4	4501	Q5T4S7
HLYHCSRLLLKLGTF	RIPOR1	906	Q6ZS17
SCLLHKASRGLLSLY	ZFYVE26	261	Q68DK2
NLLLCLASRAKRHLY	SLFN5	871	Q08AF3
CRDLSHITALFLLYL	USP6	186	P35125
LLQIIDTTLLKCYLH	VPS39	456	Q96JC1
DTTLLKCYLHTNVAL	VPS39	461	Q96JC1
KAFHCLSLYLIHERT	ZNF439	221	Q8NDP4
ILKALRHSACNLKYL	NLRP13	801	Q86W25
SLLSAILHLGNICYK	MYO9A	421	B2RTY4