Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein-glutamic acid ligase activity	TTLL6 TTLL9 TTLL13	4.45e-07	10	32	3	GO:0070739
GeneOntologyMolecularFunction	tubulin-glutamic acid ligase activity	TTLL6 TTLL9 TTLL13	4.45e-07	10	32	3	GO:0070740
GeneOntologyMolecularFunction	acid-amino acid ligase activity	TTLL6 TTLL9 TTLL13	6.48e-06	23	32	3	GO:0016881
GeneOntologyMolecularFunction	ligase activity, forming carbon-nitrogen bonds	TTLL6 TTLL9 TTLL13	8.29e-05	53	32	3	GO:0016879
GeneOntologyMolecularFunction	ligase activity	TTLL6 TTLL9 TTLL13	2.68e-03	174	32	3	GO:0016874
GeneOntologyBiologicalProcess	protein polyglutamylation	TTLL6 TTLL9 TTLL13	8.70e-07	13	31	3	GO:0018095
GeneOntologyBiologicalProcess	peptidyl-glutamic acid modification	TTLL6 TTLL9 TTLL13	1.09e-05	29	31	3	GO:0018200
GeneOntologyCellularComponent	microtubule	DNAH2 SLAIN2 TTLL6 TTLL9 TTLL13 TUBGCP3	1.38e-04	533	32	6	GO:0005874
Domain	TTL	TTLL6 TTLL9 TTLL13	1.42e-06	13	33	3	PS51221
Domain	TTL/TTLL_fam	TTLL6 TTLL9 TTLL13	1.42e-06	13	33	3	IPR004344
Domain	TTL	TTLL6 TTLL9 TTLL13	1.42e-06	13	33	3	PF03133
Domain	ATP_grasp_subdomain_2	TTLL6 TTLL9 TTLL13	2.18e-05	31	33	3	IPR013816
Domain	6-hairpin_glycosidase-like	SPATA20 TREH	2.33e-04	13	33	2	IPR008928
Pathway	REACTOME_CARBOXYTERMINAL_POST_TRANSLATIONAL_MODIFICATIONS_OF_TUBULIN	TTLL6 TTLL9 TTLL13	1.78e-05	27	27	3	MM15549
Pathway	REACTOME_CARBOXYTERMINAL_POST_TRANSLATIONAL_MODIFICATIONS_OF_TUBULIN	TTLL6 TTLL9 TTLL13	9.00e-05	46	27	3	M27828
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	JMJD4 VWA1 PPP6C L3MBTL2 FBXW9 TTLL6 TTLL9 MUC5AC SPSB3 TTLL13	1.46e-04	1389	27	10	MM15307
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	JMJD4 VWA1 PPP6C L3MBTL2 FBXW9 TTLL6 TTLL9 MUC5AC SPSB3 TTLL13	2.42e-04	1475	27	10	M19806
Pubmed	A targeted multienzyme mechanism for selective microtubule polyglutamylation.	TTLL6 TTLL9 TTLL13	2.21e-07	13	33	3	17499049
Pubmed	Tubulin polyglutamylase enzymes are members of the TTL domain protein family.	TTLL6 TTLL9 TTLL13	2.81e-07	14	33	3	15890843
Pubmed	Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.	TTLL6 TTLL9 TTLL13	1.76e-06	25	33	3	29593216
Pubmed	The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif.	DLGAP1 ZMYND11	1.83e-05	7	33	2	11148209
Pubmed	A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.	CLK1 GPRASP2 MAGEH1	5.02e-05	75	33	3	15383276
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	PRPF38B L3MBTL2 TTLL6 CLK1 GPRASP2	9.87e-05	496	33	5	31343991
Pubmed	Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	DNAH2 SLAIN2 ERI2	1.29e-04	103	33	3	10819331
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CNPPD1 DLGAP1 CLK1 GPRASP2 MAGEH1 YLPM1 AHCY	1.70e-04	1285	33	7	35914814
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	PRPF38B GLA FBXW9 GPRASP2 TUBGCP3 YLPM1	3.26e-04	1005	33	6	19615732
Pubmed	FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis.	YLPM1 AHCY	3.99e-04	31	33	2	22323290
Pubmed	Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage.	TTLL6 TTLL13	5.09e-04	35	33	2	37890489
Pubmed	Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes.	ZMYND11 L3MBTL2	7.34e-04	42	33	2	35705031
Pubmed	Genetic evidence that SOST inhibits WNT signaling in the limb.	LRP6 TGFBRAP1	8.43e-04	45	33	2	20359476
GeneFamily	Tubulin tyrosine ligase family	TTLL6 TTLL9 TTLL13	3.56e-07	14	19	3	779
Drug	phenformin hydrochloride; Up 200; 10uM; MCF7; HG-U133A	JMJD4 MEAK7 TGFBRAP1 DDIT3 YLPM1	8.98e-06	197	33	5	21_UP
Drug	Pseudopelletierine hydrochloride [6164-62-1]; Down 200; 21uM; MCF7; HT_HG-U133A	CNPPD1 LRP6 MEAK7 TGFBRAP1 YLPM1	9.43e-06	199	33	5	7184_DN
Disease	fatty liver disease (implicated_via_orthology)	LRP6 AHCY	5.20e-04	31	32	2	DOID:9452 (implicated_via_orthology)
Disease	IGFBP-3 measurement	DLGAP1 SPSB3	1.57e-03	54	32	2	EFO_0004626
Disease	susceptibility to mononucleosis measurement	DNAH2 SPATA20	2.55e-03	69	32	2	EFO_0008403
Disease	mood instability measurement	L3MBTL2 YLPM1	8.51e-03	128	32	2	EFO_0008475
Disease	photoreceptor cell layer thickness measurement	MEAK7 YLPM1	1.12e-02	148	32	2	EFO_0803370
Disease	gait measurement	TGFBRAP1 AHCY	1.15e-02	150	32	2	EFO_0007680

Protein segments in the cluster

Peptide	Gene	Start	Entry
TWSDWDLGVCLEYEC	ERI2	151	A8K979
WKDAGYEYLCIDDCW	GLA	81	P06280
WWSSDDNLDGDMCIY	DLGAP1	201	O14490
WLDDVSCYGNESALW	CD163L1	111	Q9NR16
SWGTVCDDSWDLAEA	CD163L1	1266	Q9NR16
RTYCPDWDDKDWDYG	CLK1	6	P49759
WAEDGRWVEYFCLAE	FBXW9	156	Q5XUX1
WPCNYDWDSDDDAEV	MAGEH1	191	Q9H213
DGWDSEYDQWVDCES	L3MBTL2	571	Q969R5
CIRFADGFETSWDDW	KIAA1109	3391	Q2LD37
ACDWLGEKLYWTDSE	LRP6	101	O75581
WYDLVICLDFWDSEE	GPR152	176	Q8TDT2
YITFEVLECSWDELW	TUBGCP3	721	Q96CW5
LQELCTWTEWIDGSY	MUC5AC	1951	P98088
WLDYDCDRAVIEDWV	MEAK7	186	Q6P9B6
YGWDWEADCSLEELS	CNPPD1	41	Q9BV87
DWLNEFWDALDVDDY	JMJD4	206	Q9H9V9
GTLSSWELEAWYEDL	DDIT3	11	P35638
CSSWLADAYWDNITE	DNAH2	3726	Q9P225
AWKGETDEEYLWCIE	AHCY	101	P23526
SGWEEEEESWLYSSP	SLAIN2	121	Q9P270
EAIFGSWFWDRDEAC	GPRASP2	446	Q96D09
CGEEDEYFDWVWDDL	SPSB3	96	Q6PJ21
TDWIWAGLDPDTDYD	VWA1	266	Q6PCB0
CLDEELVWAYADWVL	TGFBRAP1	536	Q8WUH2
FLWDGLWYCRGEDTE	ZNF135	116	P52742
FCDLVWSDPEDVDTW	PPP6C	191	O00743
DLYEASQESAWLEWA	SPATA20	586	Q8TB22
PTDLWDWFESFLDDE	PRPF38B	171	Q5VTL8
LWDEQTGAWFDYDLE	TREH	391	O43280
GEDDDWTLYWTDYSV	TTLL6	86	Q8N841
QERWDEDSFYGLWDT	YLPM1	1571	P49750
EVKDEGEWDFYWCDV	TTLL9	66	Q3SXZ7
EIDWETENHDWYCFE	ZMYND11	91	Q15326
EVGEDEEWTLYWTDC	TTLL13	111	A6NNM8
EEWTLYWTDCAVSLE	TTLL13	116	A6NNM8