Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	MHC class II receptor activity	HLA-DQA1 HLA-DQA2	1.82e-04	11	37	2	GO:0032395
GeneOntologyMolecularFunction	immune receptor activity	EPOR HLA-DQA1 HLA-DQA2 FCMR	2.40e-04	165	37	4	GO:0140375
GeneOntologyMolecularFunction	MHC class II protein complex binding	HLA-DQA1 HLA-DQA2	1.14e-03	27	37	2	GO:0023026
GeneOntologyMolecularFunction	MHC protein complex binding	HLA-DQA1 HLA-DQA2	2.62e-03	41	37	2	GO:0023023
GeneOntologyMolecularFunction	peptide antigen binding	HLA-DQA1 HLA-DQA2	3.72e-03	49	37	2	GO:0042605
GeneOntologyCellularComponent	trans-Golgi network membrane	KIF13A HLA-DQA1 HLA-DQA2 FCMR	4.50e-05	112	37	4	GO:0032588
GeneOntologyCellularComponent	super elongation complex	AFF1 AFF4	4.55e-05	6	37	2	GO:0032783
GeneOntologyCellularComponent	euchromatin	SIRT1 AFF4 POLR2A	2.80e-04	72	37	3	GO:0000791
GeneOntologyCellularComponent	clathrin-coated endocytic vesicle membrane	SLC2A8 HLA-DQA1 HLA-DQA2	3.68e-04	79	37	3	GO:0030669
GeneOntologyCellularComponent	MHC class II protein complex	HLA-DQA1 HLA-DQA2	4.08e-04	17	37	2	GO:0042613
GeneOntologyCellularComponent	endocytic vesicle membrane	ATG5 SLC2A8 HLA-DQA1 HLA-DQA2	5.22e-04	212	37	4	GO:0030666
GeneOntologyCellularComponent	clathrin-coated endocytic vesicle	SLC2A8 HLA-DQA1 HLA-DQA2	7.55e-04	101	37	3	GO:0045334
GeneOntologyCellularComponent	MHC protein complex	HLA-DQA1 HLA-DQA2	9.65e-04	26	37	2	GO:0042611
GeneOntologyCellularComponent	vacuole	FNIP2 ATG5 SLC2A8 HLA-DQA1 HLA-DQA2 ACAN FCMR	9.67e-04	913	37	7	GO:0005773
GeneOntologyCellularComponent	lysosomal membrane	FNIP2 SLC2A8 HLA-DQA1 HLA-DQA2 FCMR	1.26e-03	462	37	5	GO:0005765
GeneOntologyCellularComponent	lytic vacuole membrane	FNIP2 SLC2A8 HLA-DQA1 HLA-DQA2 FCMR	1.26e-03	462	37	5	GO:0098852
GeneOntologyCellularComponent	lumenal side of endoplasmic reticulum membrane	HLA-DQA1 HLA-DQA2	1.75e-03	35	37	2	GO:0098553
GeneOntologyCellularComponent	vacuolar membrane	FNIP2 SLC2A8 HLA-DQA1 HLA-DQA2 FCMR	1.89e-03	507	37	5	GO:0005774
GeneOntologyCellularComponent	trans-Golgi network	KIF13A HLA-DQA1 HLA-DQA2 FCMR	2.03e-03	306	37	4	GO:0005802
GeneOntologyCellularComponent	clathrin-coated vesicle membrane	SLC2A8 HLA-DQA1 HLA-DQA2	2.22e-03	147	37	3	GO:0030665
GeneOntologyCellularComponent	lysosome	FNIP2 SLC2A8 HLA-DQA1 HLA-DQA2 ACAN FCMR	2.78e-03	811	37	6	GO:0005764
GeneOntologyCellularComponent	lytic vacuole	FNIP2 SLC2A8 HLA-DQA1 HLA-DQA2 ACAN FCMR	2.78e-03	811	37	6	GO:0000323
GeneOntologyCellularComponent	lumenal side of membrane	HLA-DQA1 HLA-DQA2	3.27e-03	48	37	2	GO:0098576
GeneOntologyCellularComponent	endosome membrane	GPNMB KIF13A HLA-DQA1 HLA-DQA2 FCMR	3.96e-03	602	37	5	GO:0010008
GeneOntologyCellularComponent	transcription elongation factor complex	AFF1 AFF4	4.42e-03	56	37	2	GO:0008023
GeneOntologyCellularComponent	endocytic vesicle	ATG5 SLC2A8 HLA-DQA1 HLA-DQA2	4.59e-03	384	37	4	GO:0030139
GeneOntologyCellularComponent	ER to Golgi transport vesicle membrane	HLA-DQA1 HLA-DQA2	5.74e-03	64	37	2	GO:0012507
GeneOntologyCellularComponent	coated vesicle membrane	SLC2A8 HLA-DQA1 HLA-DQA2	6.44e-03	215	37	3	GO:0030662
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	ATG5 GPNMB KIF13A SLC2A8 HLA-DQA1 HLA-DQA2 FCMR	7.24e-03	1307	37	7	GO:0030659
GeneOntologyCellularComponent	Golgi apparatus subcompartment	KIF13A HLA-DQA1 HLA-DQA2 FCMR	7.56e-03	443	37	4	GO:0098791
GeneOntologyCellularComponent	vesicle membrane	ATG5 GPNMB KIF13A SLC2A8 HLA-DQA1 HLA-DQA2 FCMR	7.79e-03	1325	37	7	GO:0012506
GeneOntologyCellularComponent	clathrin-coated vesicle	SLC2A8 HLA-DQA1 HLA-DQA2	8.42e-03	237	37	3	GO:0030136
Domain	TF_AF4/FMR2	AFF1 AFF4	2.04e-05	4	35	2	IPR007797
Domain	AF-4	AFF1 AFF4	2.04e-05	4	35	2	PF05110
Domain	C1-set_C	HLA-DQA1 HLA-DQA2	3.40e-05	5	35	2	PF16196
Domain	C1-set_C	HLA-DQA1 HLA-DQA2	3.40e-05	5	35	2	IPR032431
Domain	MHC_II_alpha	HLA-DQA1 HLA-DQA2	3.40e-05	5	35	2	SM00920
Domain	MHC_II_alpha	HLA-DQA1 HLA-DQA2	5.09e-05	6	35	2	PF00993
Domain	MHC_II_a_N	HLA-DQA1 HLA-DQA2	7.12e-05	7	35	2	IPR001003
Domain	MHC_II_a/b_N	HLA-DQA1 HLA-DQA2	3.06e-04	14	35	2	IPR014745
Domain	-	HLA-DQA1 HLA-DQA2	3.06e-04	14	35	2	3.10.320.10
Domain	-	IGSF10 EPOR HLA-DQA1 HLA-DQA2 IGDCC4 FCMR	1.32e-03	663	35	6	2.60.40.10
Domain	Ig-like_fold	IGSF10 EPOR HLA-DQA1 HLA-DQA2 IGDCC4 FCMR	1.82e-03	706	35	6	IPR013783
Domain	IG_LIKE	IGSF10 HLA-DQA1 HLA-DQA2 IGDCC4 FCMR	2.08e-03	491	35	5	PS50835
Domain	MHC_I/II-like_Ag-recog	HLA-DQA1 HLA-DQA2	2.30e-03	38	35	2	IPR011162
Domain	Ig-like_dom	IGSF10 HLA-DQA1 HLA-DQA2 IGDCC4 FCMR	2.31e-03	503	35	5	IPR007110
Domain	C1-set	HLA-DQA1 HLA-DQA2	4.59e-03	54	35	2	PF07654
Domain	IGc1	HLA-DQA1 HLA-DQA2	4.93e-03	56	35	2	SM00407
Domain	Ig_C1-set	HLA-DQA1 HLA-DQA2	5.28e-03	58	35	2	IPR003597
Domain	Ig/MHC_CS	HLA-DQA1 HLA-DQA2	5.28e-03	58	35	2	IPR003006
Domain	IG_MHC	HLA-DQA1 HLA-DQA2	5.64e-03	60	35	2	PS00290
Pathway	KEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_NFY_MEDIATED_TRANSCRIPTION	HLA-DQA1 HLA-DQA2	2.64e-04	15	23	2	M47588
Pathway	KEGG_MEDICUS_REFERENCE_ANTIGEN_PROCESSING_AND_PRESENTATION_BY_MHC_CLASS_II_MOLECULES	HLA-DQA1 HLA-DQA2	2.64e-04	15	23	2	M47604
Pathway	REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE	HLA-DQA1 HLA-DQA2	3.01e-04	16	23	2	MM14808
Pathway	REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS	HLA-DQA1 HLA-DQA2	4.28e-04	19	23	2	MM14807
Pathway	REACTOME_PD_1_SIGNALING	HLA-DQA1 HLA-DQA2	4.75e-04	20	23	2	MM15001
Pubmed	A molecular basis for the Ia.2 and Ia.19 antigenic determinants.	HLA-DQA1 HLA-DQA2	1.10e-06	2	37	2	2581258
Pubmed	PCR-RFLP genotyping of murine MHC haplotypes.	HLA-DQA1 HLA-DQA2	1.10e-06	2	37	2	8879564
Pubmed	HLA-DQ6 transgenic mice resistance to experimental autoimmune myasthenia gravis is linked to reduced acetylcholine receptor-specific IFN-gamma, IL-2 and IL-10 production.	HLA-DQA1 HLA-DQA2	1.10e-06	2	37	2	11712854
Pubmed	Gastric mucosal hyperplasia via upregulation of gastrin induced by persistent activation of gastric innate immunity in major histocompatibility complex class II deficient mice.	HLA-DQA1 HLA-DQA2	1.10e-06	2	37	2	16322110
Pubmed	Distinct roles of two SEC scaffold proteins, AFF1 and AFF4, in regulating RNA polymerase II transcription elongation.	AFF1 AFF4	1.10e-06	2	37	2	37528066
Pubmed	Characterization of defective I-A surface expression in a mixed isotype expressing murine B cell lymphoma: continued expression of E alpha d A beta d despite competition from restored A alpha d A beta d pairs.	HLA-DQA1 HLA-DQA2	1.10e-06	2	37	2	1329933
Pubmed	Structure and expression of HLA-DQ alpha and -DX alpha genes: interallelic alternate splicing of the HLA-DQ alpha gene and functional splicing of the HLA-DQ alpha gene using a retroviral vector.	HLA-DQA1 HLA-DQA2	1.10e-06	2	37	2	3610256
Pubmed	Development of a major histocompatibility complex class II conditional knockout mouse to study cell-specific and time-dependent adaptive immune responses in peripheral nerves.	HLA-DQA1 HLA-DQA2	1.10e-06	2	37	2	38922958
Pubmed	The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders.	HLA-DQA1 HLA-DQA2	1.10e-06	2	37	2	8543793
Pubmed	AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter.	AFF1 AFF4	1.10e-06	2	37	2	24843025
Pubmed	Hypoxanthine-xanthine oxidase down-regulates GLUT1 transcription via SIRT1 resulting in decreased glucose uptake in human placenta.	XDH SIRT1	1.10e-06	2	37	2	22266962
Pubmed	Major histocompatibility complex class II expression by intrinsic renal cells is required for crescentic glomerulonephritis.	HLA-DQA1 HLA-DQA2	1.10e-06	2	37	2	9687536
Pubmed	Functional adaptive CD4 Foxp3 T cells develop in MHC class II-deficient mice.	HLA-DQA1 HLA-DQA2	1.10e-06	2	37	2	17142726
Pubmed	Targeted disruption of the MHC class II Aa gene in C57BL/6 mice.	HLA-DQA1 HLA-DQA2	1.10e-06	2	37	2	8398989
Pubmed	Impaired ability of MHC class II-/- dendritic cells to provide tumor protection is rescued by CD40 ligation.	HLA-DQA1 HLA-DQA2	1.10e-06	2	37	2	10384102
Pubmed	Increasing the survival of dendritic cells in vivo does not replace the requirement for CD4+ T cell help during primary CD8+ T cell responses.	HLA-DQA1 HLA-DQA2	1.10e-06	2	37	2	17947646
Pubmed	Regions of allelic hypervariability in the murine A alpha immune response gene.	HLA-DQA1 HLA-DQA2	1.10e-06	2	37	2	6309407
Pubmed	SIRT1/Atg5/autophagy are involved in the antiatherosclerosis effects of ursolic acid.	ATG5 SIRT1	1.10e-06	2	37	2	27514536
Pubmed	Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes.	HLA-DQA1 HLA-DQA2	1.10e-06	2	37	2	7722444
Pubmed	Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regression.	HLA-DQA1 HLA-DQA2	1.10e-06	2	37	2	25252912
Pubmed	A comparative approach linking molecular dynamics of altered peptide ligands and MHC with in vivo immune responses.	HLA-DQA1 HLA-DQA2	1.10e-06	2	37	2	20657836
Pubmed	Gene target specificity of the Super Elongation Complex (SEC) family: how HIV-1 Tat employs selected SEC members to activate viral transcription.	AFF1 AFF4	1.10e-06	2	37	2	26007649
Pubmed	Ancient roots for polymorphism at the HLA-DQ alpha locus in primates.	HLA-DQA1 HLA-DQA2	1.10e-06	2	37	2	2513578
Pubmed	PPARα and Sirt1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders.	EPOR SIRT1	1.10e-06	2	37	2	23990359
Pubmed	CD8+ T cells are capable of rejecting pancreatic islet xenografts.	HLA-DQA1 HLA-DQA2	1.10e-06	2	37	2	11014643
Pubmed	Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells.	HLA-DQA1 HLA-DQA2	1.10e-06	2	37	2	9334361
Pubmed	CD1d-restricted NKT cells contribute to malarial splenomegaly and enhance parasite-specific antibody responses.	HLA-DQA1 HLA-DQA2	1.10e-06	2	37	2	12938235
Pubmed	The Role of RNA Polymerase II Elongation Control in HIV-1 Gene Expression, Replication, and Latency.	AFF1 AFF4 POLR2A	1.68e-06	22	37	3	22567366
Pubmed	Revisiting the specificity of the MHC class II transactivator CIITA in vivo.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	16703565
Pubmed	Crystal structure of I-Ak in complex with a dominant epitope of lysozyme.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	9529148
Pubmed	MHC class II-independent CD25+ CD4+ CD8alpha beta+ alpha beta T cells attenuate CD4+ T cell-induced transfer colitis.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	14991600
Pubmed	Low-Level MHC Class II Expression Leads to Suboptimal Th Cell Response, Increased Autoaggression, and Heightened Cytokine Inducibility.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	28108557
Pubmed	Alternate interactions define the binding of peptides to the MHC molecule IA(b).	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	12084926
Pubmed	T cell-dependence of Lassa fever pathogenesis.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	20360949
Pubmed	Implications of aging and self-tolerance on the generation of immune and antitumor immune responses.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	18593945
Pubmed	Activated mouse T-cells synthesize MHC class II, process, and present morbillivirus nucleocapsid protein to primed T-cells.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	16083868
Pubmed	A novel inducible von Willebrand Factor Cre recombinase mouse strain to study microvascular endothelial cell-specific biological processes in vivo.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	38554988
Pubmed	Dissecting MHC class II export, B cell maturation, and DM stability defects in invariant chain mutant mice.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	15322189
Pubmed	Indirect presentation in the thymus limits naive and regulatory T-cell differentiation by promoting deletion of self-reactive thymocytes.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	29411880
Pubmed	The murine Ia alpha chains, E alpha and A alpha, show a surprising degree of sequence homology.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	6300851
Pubmed	Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	9053454
Pubmed	A triad of molecular regions contribute to the formation of two distinct MHC class II conformers.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	27148821
Pubmed	Rapid Death of Follicular B Cells and Burkitt Lymphoma Cells Effectuated by Xbp1s.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	32376649
Pubmed	Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	6584734
Pubmed	Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	12589760
Pubmed	HLA class II nucleotide sequences, 1992.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	1362295
Pubmed	Protection from radiation-induced colitis requires MHC class II antigen expression by cells of hemopoietic origin.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	10491007
Pubmed	Circulating, soluble forms of major histocompatibility complex antigens are not exosome-associated.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	17072917
Pubmed	Interdependency of MHC class II/self-peptide and CD1d/self-glycolipid presentation by TNF-matured dendritic cells for protection from autoimmunity.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	17404272
Pubmed	The autophagy-activating kinase ULK1 mediates clearance of free α-globin in β-thalassemia.	ATG5 EPOR	3.30e-06	3	37	2	31434755
Pubmed	The class II molecules of the human and murine major histocompatibility complex.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	6198089
Pubmed	Type I IFN-induced, NKT cell-mediated negative control of CD8 T cell priming by dendritic cells.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	18641299
Pubmed	Comparative sequence analysis of cDNA clones encoding I-A molecules of the CH12 B cell lymphoma: nucleotide differences do not account for their "defective" function in B cell stimulation.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	3500915
Pubmed	Plasmacytoid dendritic cells induce tolerance predominantly by cargoing antigen to lymph nodes.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	27592607
Pubmed	The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	2882518
Pubmed	Life-span, T-cell responses, and incidence of lymphomas in congenic mice.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	7732019
Pubmed	Signaling to a B-cell clone by Ek, but not Ak, does not reflect alteration of Ak genes.	HLA-DQA1 HLA-DQA2	3.30e-06	3	37	2	3137158
Pubmed	AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23).	AFF1 AFF4	3.30e-06	3	37	2	10588740
Pubmed	Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha.	EPOR HLA-DQA1 HLA-DQA2	5.38e-06	32	37	3	9611252
Pubmed	Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity.	HLA-DQA1 HLA-DQA2	6.60e-06	4	37	2	18799151
Pubmed	Importance of a specific amino acid pairing for murine MLL leukemias driven by MLLT1/3 or AFF1/4.	AFF1 AFF4	6.60e-06	4	37	2	25282333
Pubmed	HLA variants rs9271366 and rs9275328 are associated with systemic lupus erythematosus susceptibility in Malays and Chinese.	HLA-DQA1 HLA-DQA2	6.60e-06	4	37	2	23257407
Pubmed	Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes.	HLA-DQA1 HLA-DQA2	6.60e-06	4	37	2	11376336
Pubmed	MHC class II upregulation and colocalization with Fas in experimental models of immune-mediated bone marrow failure.	HLA-DQA1 HLA-DQA2	6.60e-06	4	37	2	21635935
Pubmed	Toxoplasma gondii down-regulates MHC class II gene expression and antigen presentation by murine macrophages via interference with nuclear translocation of STAT1alpha.	HLA-DQA1 HLA-DQA2	6.60e-06	4	37	2	11465104
Pubmed	Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation.	ATG5 SIRT1	6.60e-06	4	37	2	25316028
Pubmed	Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes.	HLA-DQA1 HLA-DQA2	6.60e-06	4	37	2	3036828
Pubmed	MHC class II-restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell-mediated autoimmunity.	HLA-DQA1 HLA-DQA2	6.60e-06	4	37	2	20696698
Pubmed	A Minor Subset of Super Elongation Complexes Plays a Predominant Role in Reversing HIV-1 Latency.	AFF1 AFF4	6.60e-06	4	37	2	26830226
Pubmed	Antigen presentation and T cell development in H2-M-deficient mice.	HLA-DQA1 HLA-DQA2	6.60e-06	4	37	2	8638109
Pubmed	Molecular analysis of the pathogenesis of autoimmune insulitis in NOD mice.	HLA-DQA1 HLA-DQA2	6.60e-06	4	37	2	7809906
Pubmed	Altered major histocompatibility complex class II peptide loading in H2-O-deficient mice.	HLA-DQA1 HLA-DQA2	6.60e-06	4	37	2	11069069
Pubmed	MHC characterization of ALR and ALS mice: respective similarities to the NOD and NON strains.	HLA-DQA1 HLA-DQA2	6.60e-06	4	37	2	10369935
Pubmed	The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization.	HLA-DQA1 HLA-DQA2	6.60e-06	4	37	2	47219
Pubmed	H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection.	HLA-DQA1 HLA-DQA2	6.60e-06	4	37	2	8598041
Pubmed	Analysis of MHC class II genes in the susceptibility to lupus in New Zealand mice.	HLA-DQA1 HLA-DQA2	6.60e-06	4	37	2	10072504
Pubmed	Nonobese diabetic and nonobese nondiabetic mice have unique MHC class II haplotypes.	HLA-DQA1 HLA-DQA2	6.60e-06	4	37	2	1855817
Pubmed	Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out mice.	AFF1 AFF4	6.60e-06	4	37	2	11923441
Pubmed	A new common integration region (int-3) for mouse mammary tumor virus on mouse chromosome 17.	HLA-DQA1 HLA-DQA2	6.60e-06	4	37	2	3023699
Pubmed	Mediation of Af4 protein function in the cerebellum by Siah proteins.	AFF1 AFF4	6.60e-06	4	37	2	15459319
Pubmed	The Th2 lymphoproliferation developing in LatY136F mutant mice triggers polyclonal B cell activation and systemic autoimmunity.	HLA-DQA1 HLA-DQA2	6.60e-06	4	37	2	16887989
Pubmed	Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk).	HLA-DQA1 HLA-DQA2	6.60e-06	4	37	2	11283154
Pubmed	MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway.	HLA-DQA1 HLA-DQA2	6.60e-06	4	37	2	30001419
Pubmed	MHC class II-alpha chain knockout mice support increased viral replication that is independent of their lack of MHC class II cell surface expression and associated immune function deficiencies.	HLA-DQA1 HLA-DQA2	6.60e-06	4	37	2	23840854
Pubmed	Reconstitution of an operational MHC class II compartment in nonantigen-presenting cells.	HLA-DQA1 HLA-DQA2	1.10e-05	5	37	2	7985028
Pubmed	Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies.	HLA-DQA1 HLA-DQA2	1.10e-05	5	37	2	24336796
Pubmed	MHC class II expression in double mutant mice lacking invariant chain and DM functions.	HLA-DQA1 HLA-DQA2	1.10e-05	5	37	2	9551894
Pubmed	The Tec Kinase Itk Integrates Naïve T Cell Migration and In Vivo Homeostasis.	HLA-DQA1 HLA-DQA2	1.10e-05	5	37	2	34566971
Pubmed	A genome-wide association study reveals ARL15, a novel non-HLA susceptibility gene for rheumatoid arthritis in North Indians.	HLA-DQA1 HLA-DQA2	1.10e-05	5	37	2	23918589
Pubmed	A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.	ATG5 SIRT1	1.10e-05	5	37	2	18296641
Pubmed	H2-Mbeta 1 and H2-Mbeta 2 heterodimers equally promote clip removal in I-A(q) molecules from autoimmune-prone DBA/1 mice.	HLA-DQA1 HLA-DQA2	1.10e-05	5	37	2	11148202
Pubmed	Deletion of self-reactive CCR7- thymocytes in the absence of MHC expression on thymic epithelial cells.	HLA-DQA1 HLA-DQA2	1.10e-05	5	37	2	31019259
Pubmed	Conditional gene targeting in macrophages and granulocytes using LysMcre mice.	HLA-DQA1 HLA-DQA2	1.10e-05	5	37	2	10621974
Pubmed	Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice.	HLA-DQA1 HLA-DQA2	1.10e-05	5	37	2	9491996
Pubmed	The notch receptor and its ligands are selectively expressed during hematopoietic development in the mouse.	EPOR NOTCH2	1.10e-05	5	37	2	11713346
Pubmed	Detection of a new cerebral malaria susceptibility locus, using CBA mice.	HLA-DQA1 HLA-DQA2	1.10e-05	5	37	2	15536567
Pubmed	Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway.	HLA-DQA1 HLA-DQA2	1.10e-05	5	37	2	8598040
Pubmed	ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome.	MAP3K20 NLRP1	1.10e-05	5	37	2	35857590
Pubmed	The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice.	HLA-DQA1 HLA-DQA2	1.10e-05	5	37	2	22505458
Pubmed	Immunochemical evidence for three Ia loci in the I-region of the H-2 complex.	HLA-DQA1 HLA-DQA2	1.10e-05	5	37	2	72779
Interaction	ZNF765 interactions	CUL9 INCA1 NOTCH2	1.12e-05	24	37	3	int:ZNF765
Interaction	ELL3 interactions	AFF1 SIRT1 AFF4	1.44e-05	26	37	3	int:ELL3
Interaction	HLA-DQA2 interactions	HLA-DQA1 HLA-DQA2	4.90e-05	6	37	2	int:HLA-DQA2
Interaction	MLLT1 interactions	AFF1 SIRT1 AFF4 POLR2A	7.47e-05	123	37	4	int:MLLT1
Interaction	ZNF761 interactions	CUL9 NOTCH2	1.17e-04	9	37	2	int:ZNF761
Interaction	ZNF480 interactions	CUL9 NOTCH2	1.17e-04	9	37	2	int:ZNF480
Cytoband	17p13.2	NLRP1 INCA1	9.14e-04	55	37	2	17p13.2
GeneFamily	AF4/FMR2 family\|Super elongation complex	AFF1 AFF4	1.39e-05	4	28	2	1145
GeneFamily	AF4/FMR2 family\|Super elongation complex	AFF1 AFF4	8.27e-05	9	28	2	1280
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	PKD1L2 ACAN	1.83e-03	41	28	2	1298
GeneFamily	C1-set domain containing	HLA-DQA1 HLA-DQA2	1.92e-03	42	28	2	591
GeneFamily	Histocompatibility complex\|C1-set domain containing	HLA-DQA1 HLA-DQA2	2.10e-03	44	28	2	588
Coexpression	GSE7852_LN_VS_THYMUS_TREG_UP	XDH PGGHG KIF13A HLA-DQA1 FCMR	8.79e-06	200	37	5	M5737
Coexpression	FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN	FNIP2 AFF1 GPNMB SIRT1 NOTCH2 POLR2A	4.05e-05	458	37	6	M4785
Coexpression	LEE_TARGETS_OF_PTCH1_AND_SUFU_UP	GPNMB HLA-DQA1 HLA-DQA2	8.38e-05	60	37	3	MM601
Coexpression	TABULA_MURIS_SENIS_LUNG_SMOOTH_MUSCLE_CELL_OF_THE_PULMONARY_ARTERY_AGEING	HLA-DQA1 HLA-DQA2	1.06e-04	11	37	2	MM3774
Coexpression	KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN	AFF1 NLRP1 GPNMB DISP1 IGDCC4	1.06e-04	337	37	5	M13206
Coexpression	TABULA_MURIS_SENIS_SUBCUTANEOUS_ADIPOSE_TISSUE_ENDOTHELIAL_CELL_AGEING	CRISPLD2 HLA-DQA1 HLA-DQA2 AFF4	1.07e-04	175	37	4	MM3823
Coexpression	TABULA_MURIS_SENIS_LUNG_VEIN_ENDOTHELIAL_CELL_AGEING	HLA-DQA1 HLA-DQA2	1.27e-04	12	37	2	MM3776
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FNIP2 MAP3K20 ZNF469 HLA-DQA1 HLA-DQA2	5.52e-07	194	37	5	b16ed97eb6b7b7a220e943474c0d85c141b6e3a5
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FNIP2 MAP3K20 ZNF469 HLA-DQA1 HLA-DQA2	5.52e-07	194	37	5	2210f0755882d8f04edb4c109fb17c3f9149f6f7
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	IGSF10 ZNF469 HLA-DQA1 HLA-DQA2	7.78e-06	153	37	4	91e9d70a5d3f6fd68c284ed0cc113f03d7d1e10b
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGSF10 ZNF469 HLA-DQA1 HLA-DQA2	7.78e-06	153	37	4	f17f62646633cf95c810dcd5328978058741b276
ToppCell	ICU-SEP-Myeloid-cDC1\|ICU-SEP / Disease, Lineage and Cell Type	FNIP2 HLA-DQA1 HLA-DQA2 DISP1	9.51e-06	161	37	4	9fb73909fc2ec99f96ca2eed1a053bce89de7d16
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKD1L2 HLA-DQA1 SIRT1 FCMR	1.15e-05	169	37	4	befb9b1618ea30fbf8983bcc493853da53b809c3
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKD1L2 HLA-DQA1 SIRT1 FCMR	1.15e-05	169	37	4	d18b823836ca6fba79a2d2f10cb9966fa2623af2
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_memory-B_memory-6\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TAS1R3 HLA-DQA1 HLA-DQA2 FCMR	1.32e-05	175	37	4	1b3510e9078eec7cfc5805043e435e9e5e0f0877
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_memory-B_memory-6\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TAS1R3 HLA-DQA1 HLA-DQA2 FCMR	1.32e-05	175	37	4	eaec7fda07a9537d067ca13b607a8ab201caa7c4
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-B_cell-B_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GDPD4 HLA-DQA1 NOTCH2 FCMR	1.35e-05	176	37	4	27c132e9852717cbc345af7a1fc390e9ea589416
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-B_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GDPD4 HLA-DQA1 NOTCH2 FCMR	1.35e-05	176	37	4	259d1864fb0a6d2feddc90bc715e2bccbb373792
ToppCell	Healthy-B_memory\|World / disease group, cell group and cell class	TAS1R3 HLA-DQA1 HLA-DQA2 FCMR	1.41e-05	178	37	4	b4848b95f2b449c9fac9b5560d959af1788a6f3b
ToppCell	ILEUM-non-inflamed-(3)_DC1\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	FNIP2 TMEM132E HLA-DQA1 HLA-DQA2	1.51e-05	181	37	4	c9f53720249c8569598cc859e43e35c5f3f8475a
ToppCell	URO-Lymphocyte-B-B_memory\|URO / Disease, Lineage and Cell Type	TAS1R3 HLA-DQA1 HLA-DQA2 FCMR	1.54e-05	182	37	4	8ffdf15230349ad53fe15bb467724d28c5a05bf6
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Monocytic-Nonclassical_Monocyte\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FNIP2 GPNMB HLA-DQA1 HLA-DQA2	1.57e-05	183	37	4	4cc0961a67de76b8d756cd9ffcaa98e3fe3c3a69
ToppCell	Control-Lymphocyte-B-B_intermediate\|Control / Disease, Lineage and Cell Type	TAS1R3 HLA-DQA1 HLA-DQA2 FCMR	1.71e-05	187	37	4	90c9b1a51539838323325f563be4adf5fdf1b38f
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-6\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TAS1R3 HLA-DQA1 HLA-DQA2 FCMR	1.75e-05	188	37	4	18d16e3f095a109b6a690f46fe7fcd5674c3636b
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TAS1R3 HLA-DQA1 HLA-DQA2 FCMR	1.79e-05	189	37	4	2b53dae0e6e85b7139f8a9872fbebb3705b2f1bf
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FNIP2 GPNMB HLA-DQA1 HLA-DQA2	1.79e-05	189	37	4	0a490730cdc912d5233de59057550de0e4065747
ToppCell	COVID-19_Severe-Lymphoid_B-B_memory\|COVID-19_Severe / Disease group, lineage and cell class	TAS1R3 HLA-DQA1 HLA-DQA2 FCMR	1.82e-05	190	37	4	b6510c419a15ed049c0a0a6a6697b643668741c3
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	AFF1 HLA-DQA1 HLA-DQA2 FCMR	1.82e-05	190	37	4	0724665ac8238f2383c3a929d89abf4a48ec2420
ToppCell	VE-mDC1\|VE / Condition, Cell_class and T cell subcluster	FNIP2 TMEM132E HLA-DQA1 HLA-DQA2	1.94e-05	193	37	4	12b2708db9db8b88365b8ebeb4908f28c50081bb
ToppCell	VE-mDC1-\|VE / Condition, Cell_class and T cell subcluster	FNIP2 TMEM132E HLA-DQA1 HLA-DQA2	1.94e-05	193	37	4	5df6033bc0e4f96a20d526486a8e89c990e21831
ToppCell	remission-B_intermediate\|World / disease stage, cell group and cell class	TAS1R3 HLA-DQA1 HLA-DQA2 FCMR	1.98e-05	194	37	4	78556b60c84c7bbffa1c8bf8684b3c427512da44
ToppCell	(010)_cDC\|World / immune cells in Peripheral Blood (logTPM normalization)	FNIP2 MAP3K20 HLA-DQA1 HLA-DQA2	2.02e-05	195	37	4	4aabb3f5ce70100e4d98d7fa9f8d12e84fb9fe3d
ToppCell	Sepsis-ICU-SEP-Myeloid-cDC1\|ICU-SEP / Disease, condition lineage and cell class	FNIP2 HLA-DQA1 HLA-DQA2 DISP1	2.10e-05	197	37	4	e3174e90ea6136f1aa3a4a185b86458e35d51fd4
ToppCell	mild_COVID-19-cDC\|mild_COVID-19 / disease group, cell group and cell class (v2)	FNIP2 ZNF469 HLA-DQA1 HLA-DQA2	2.10e-05	197	37	4	44ebd3f967779bb7753fc6dcd9fde6d682f9ccd6
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FNIP2 MAP3K20 HLA-DQA1 HLA-DQA2	2.14e-05	198	37	4	898ef4f02443780f9b1fc08b73a165fda0ca5cde
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-conventional_dendritic_cell\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MAP3K20 ZNF469 HLA-DQA1 HLA-DQA2	2.14e-05	198	37	4	08ad0bece508bb4f9cc126d94839b5c89ce21ba8
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_B\|lymph-node_spleen / Manually curated celltypes from each tissue	HLA-DQA1 HLA-DQA2 NOTCH2 FCMR	2.14e-05	198	37	4	1780fa1725a321041094e8c4430673c0a4f3d407
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-conventional_dendritic_cell\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FNIP2 MAP3K20 HLA-DQA1 HLA-DQA2	2.14e-05	198	37	4	42be18aef4f656a86c61630b061826a858c496fd
ToppCell	5'-Adult-SmallIntestine-Mesenchymal\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MAP3K20 IGSF10 CRISPLD2 GPNMB	2.23e-05	200	37	4	a637281d91e95734ee4f8510b3780e0272b16fda
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P3\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ZNF469 GPNMB ACAN	5.73e-05	90	37	3	a0baaf2b3cf07d457f0d242fc213689cba6fd449
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P3-Tnr\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ZNF469 GPNMB ACAN	5.73e-05	90	37	3	ab4b08c6ac8695b38f841c0ecf2bb2c032111d04
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Gpr149_Islr\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MAP3K20 GPNMB ACAN	1.55e-04	126	37	3	3539a8fdbb52d191f36dce68c38798ad4d2b491a
ToppCell	PND07-28-samps-Lymphocyte-B_cell-B_cell_2\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	TAS1R3 HLA-DQA1 FCMR	1.99e-04	137	37	3	2544d1256f11da6e3bad24a871b2253e0ab20d01
ToppCell	PND07-28-samps-Lymphocyte-B_cell\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	TAS1R3 HLA-DQA1 FCMR	1.99e-04	137	37	3	874e2eaa7846a2832f46b77c726d79f220a4a1cd
ToppCell	Control-B_naive-11\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	HLA-DQA1 HLA-DQA2 FCMR	2.08e-04	139	37	3	2af7ad44b707d139c6f055e63d68c09b5c1bb1be
ToppCell	Mild/Remission-B_naive-1\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	MAP3K20 PGGHG FCMR	2.26e-04	143	37	3	bd3f5fbd4e9e4dc414682db5607494f3ce988deb
ToppCell	facs-Marrow-T-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNIP2 CRISPLD2 XDH	2.50e-04	148	37	3	ba277c898678dd36f8dc1d681301c71901b89055
ToppCell	facs-Marrow-T-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNIP2 CRISPLD2 XDH	2.50e-04	148	37	3	b4632029ebd14969bda59a1bd1454eadb8efe563
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Akr1c18_Ntf3\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MAP3K20 GPNMB ACAN	2.55e-04	149	37	3	1e77f03d2b32f366018fec3462d1b75f6e7febb9
ToppCell	Dendritic_Cells-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	ZNF469 HLA-DQA1 HLA-DQA2	2.65e-04	151	37	3	e089bf197ed60e7243160521d4390d4b40a3832b
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MAP3K20 KIF13A ACAN	2.70e-04	152	37	3	0cb5f4dfae04e3f4eba502bbf229007d5fa3884d
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MAP3K20 KIF13A ACAN	2.70e-04	152	37	3	ba89ffb5a8bb33c188f854f54b39123b6d73496a
ToppCell	PND03-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CRISPLD2 ZSCAN22 HARBI1	2.75e-04	153	37	3	489228ab81c3ae339a53a9da6c2a1c1b6ac3f84b
ToppCell	facs-Brain_Myeloid-Cortex-24m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XDH HLA-DQA1 FCMR	2.81e-04	154	37	3	1e088b0d4a44267f46a9b643f46a1aba784686b1
ToppCell	(2)_NK/T-(23)_CD4+_T_cell-(230)_CD4+/CD25+_Reg_T_cell\|(23)_CD4+_T_cell / immune cells in Peripheral Blood (logTPM normalization)	CUL9 HLA-DQA1 HLA-DQA2	2.81e-04	154	37	3	059bdf6843f94f5028d4df6aa025865a9edb4521
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_11\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FNIP2 HLA-DQA1 HLA-DQA2	2.81e-04	154	37	3	5967a0a33456d5930fc492a700ebb015ac050abb
ToppCell	Adult-Immune-dendritic_cell-D122\|Adult / Lineage, Cell type, age group and donor	ZSCAN22 HLA-DQA1 HLA-DQA2	2.81e-04	154	37	3	64a4686586d08b1e9632dde917b472ac660de2d3
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_3\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FNIP2 HLA-DQA1 HLA-DQA2	2.86e-04	155	37	3	9a27558c457f05808af07190b7a5006b047f1d58
ToppCell	E18.5-Immune-Immune_Lymphocytic_T/NK\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PKD1L2 HLA-DQA1 FCMR	2.86e-04	155	37	3	efe69145910c5e049d0ed30699c26ef963e0a285
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_3\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FNIP2 HLA-DQA1 HLA-DQA2	2.86e-04	155	37	3	ab539c04f10276ae919d82b1c75f99a84eb695bf
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_11\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FNIP2 HLA-DQA1 HLA-DQA2	2.86e-04	155	37	3	fab281db4c275d51240b122be78713c839ba5a95
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KIF13A ACAN RHBDL3	2.86e-04	155	37	3	77fdae85d36efb776db977eb424b32487ef222e4
ToppCell	Control-B_naive-1\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	PGGHG NOTCH2 FCMR	2.86e-04	155	37	3	0a78d1cab2bdba2dc8a74cdf35b5a0192370c4b5
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Monocytic-Nonclassical_Monocyte\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	INCA1 HLA-DQA1 HLA-DQA2	2.86e-04	155	37	3	96c48d835725eac1bc7926f4cddecb67c29b7d7c
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_3\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FNIP2 MAP3K20 HLA-DQA1	2.91e-04	156	37	3	841d653d74c4de41d2f9a114f6ccb92d6a1ebc24
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_3\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FNIP2 MAP3K20 HLA-DQA1	2.91e-04	156	37	3	a917b3e799a7b2a3c7f36af61f2b69292c0fb5c0
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PGGHG HLA-DQA1 FCMR	2.97e-04	157	37	3	6730b775308f45a2f3946016bdbb7f8e5b5efe49
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_4\|368C / Donor, Lineage, Cell class and subclass (all cells)	GPNMB HLA-DQA1 HLA-DQA2	3.02e-04	158	37	3	f9cfb110342be3c91aba9914805332f22ba89101
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_6\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF469 HLA-DQA1 HLA-DQA2	3.08e-04	159	37	3	6115cb03c2ad08e4c1b65893d522f685ff0bc692
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-11\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HLA-DQA1 HLA-DQA2 FCMR	3.14e-04	160	37	3	8396afbc7d919ba190863d50aa0ef8b9942a9866
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_6\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ZNF469 HLA-DQA1 HLA-DQA2	3.14e-04	160	37	3	a90eb621481fd07a821495db07d1032e109fd386
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage_2\|368C / Donor, Lineage, Cell class and subclass (all cells)	GPNMB HLA-DQA1 HLA-DQA2	3.14e-04	160	37	3	ac3f56f8ab8efd11c4b4868a828db05c23ac762f
ToppCell	Bac-SEP-Lymphocyte-B-B_intermediate\|Bac-SEP / Disease, Lineage and Cell Type	HLA-DQA1 HLA-DQA2 FCMR	3.20e-04	161	37	3	bcd122af09cbb99d1816200d9c367af8b7f36873
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Pvalb\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MAP3K20 GPNMB ACAN	3.31e-04	163	37	3	db6b7ce6f7221bb73c5e650ac51cdd5d7ef00675
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_5\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HLA-DQA1 HLA-DQA2 RHBDL3	3.37e-04	164	37	3	3a4ecc632be003d09b765c992804134348d2278b
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Tpbg\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MAP3K20 GPNMB ACAN	3.37e-04	164	37	3	f0499e6c1b17c4df72b18b294e3b53ef723da2ac
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_5\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	HLA-DQA1 HLA-DQA2 RHBDL3	3.37e-04	164	37	3	4b10b78d4d76023c3c5bcd427757218fdd5465ca
ToppCell	Int-URO-Myeloid-tDC\|Int-URO / Disease, Lineage and Cell Type	IGSF10 HLA-DQA1 HLA-DQA2	3.43e-04	165	37	3	9803c3db6cdcf925bea7d9c382bf4fd05acf3509
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HLA-DQA1 HLA-DQA2 FCMR	3.43e-04	165	37	3	fead3f2032f8fa5f7f0159a4434989b3d65debbb
ToppCell	droplet-Fat-SCAT-30m-Lymphocytic-B_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TAS1R3 HLA-DQA1 FCMR	3.49e-04	166	37	3	4b31d2755108b2815316411a38bfb11fd30ef98a
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Tpbg\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MAP3K20 GPNMB ACAN	3.49e-04	166	37	3	b4241f8d2a0aa910dbb0d0d5d3631a9b73453fe9
ToppCell	facs-Heart-LA-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKD1L2 HLA-DQA1 FCMR	3.56e-04	167	37	3	8340f7075d00dccb304cfd4c9b5711ca6dbf7cce
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GIT2 GPNMB SIRT1	3.56e-04	167	37	3	881f64db8dea3faa7588bf04d87c20924a4e5952
ToppCell	facs-Lung-EPCAM-24m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GDPD4 HLA-DQA1 FCMR	3.56e-04	167	37	3	691f3589de0f8c13f9137812cfa9040c07d237b4
ToppCell	facs-Heart-LA-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKD1L2 HLA-DQA1 FCMR	3.56e-04	167	37	3	8ce8d93c79ac6a3f52252b4cec53378c362bfe0a
ToppCell	severe-Myeloid-mDC\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	IGSF10 HLA-DQA1 HLA-DQA2	3.56e-04	167	37	3	50b1cea9048bd8df9aff3fb9a548443f950d1090
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-4\|TCGA-Lung / Sample_Type by Project: Shred V9	CRISPLD2 ZNF469 IGDCC4	3.62e-04	168	37	3	aefea14b8b1c1b6a05f827effd22ba15274fddc9
ToppCell	Int-URO-Lymphocyte-B-B_intermediate\|Int-URO / Disease, Lineage and Cell Type	HLA-DQA1 HLA-DQA2 FCMR	3.62e-04	168	37	3	5b3fb1fc8fea810c6d4e6feb42c24fb57e8066de
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.4.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GPNMB HLA-DQA1 HLA-DQA2	3.62e-04	168	37	3	eba865465feb0f42055bb8f98946050eeb03d177
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MAP3K20 GPNMB ACAN	3.62e-04	168	37	3	2572a3dd4f3f619bd26a3cd6e60de43821d8bb64
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_B-ABC_aged-B_naive\|lymph-node_spleen / Manually curated celltypes from each tissue	HLA-DQA1 HLA-DQA2 FCMR	3.62e-04	168	37	3	494d5a11154ff22fedb25f4036d730cef376da60
ToppCell	NS-critical-d_0-4-Myeloid-Monocyte-derived_DC\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ZNF469 GPNMB HLA-DQA1	3.68e-04	169	37	3	6fe82db874eff0f86e5c0d1cc81322eb9d7874eb
ToppCell	URO-Lymphocyte-B-B_intermediate\|URO / Disease, Lineage and Cell Type	HLA-DQA1 HLA-DQA2 FCMR	3.75e-04	170	37	3	e11d1510518cedabeece96d4adbb90999e6326fa
ToppCell	droplet-Fat-Gat-18m-Lymphocytic-B_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HLA-DQA1 HARBI1 FCMR	3.75e-04	170	37	3	5185187ecf26b4c9eaa0c01ad52697ab8d075cc7
ToppCell	10x5'-Liver-Lymphocytic_B-ABC_aged-B_memory\|Liver / Manually curated celltypes from each tissue	HLA-DQA1 HLA-DQA2 FCMR	3.81e-04	171	37	3	eb47f4a09a630ed14a0898377039ed50ef7cc292
ToppCell	ICU-NoSEP-Lymphocyte-B-B_intermediate\|ICU-NoSEP / Disease, Lineage and Cell Type	HLA-DQA1 HLA-DQA2 FCMR	3.81e-04	171	37	3	c6b8578577aef4fe79c1a8ca778a068052f2c9d4
ToppCell	facs-Thymus-Flowthrough-3m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HLA-DQA1 HARBI1 FCMR	3.88e-04	172	37	3	356a66cd9303470e427005cc67fdd22a2c4bf971
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HLA-DQA1 HLA-DQA2 FCMR	3.88e-04	172	37	3	172e3c78f8e97988a4fd8624514e731282ddc16d
ToppCell	facs-Thymus-Flowthrough-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HLA-DQA1 HARBI1 FCMR	3.88e-04	172	37	3	46fadeee483fdf8402df92ec98575a09c6c15b16
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HLA-DQA1 HLA-DQA2 FCMR	3.88e-04	172	37	3	5fb0ea6145892a258696197b3feed9760187e712
ToppCell	facs-Spleen-nan-24m-Lymphocytic-CD79a_B_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HLA-DQA1 POLR2A FCMR	3.88e-04	172	37	3	0c6332a806ac75fffae6080f61965555c7f687f4
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B-B_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HLA-DQA1 HLA-DQA2 FCMR	3.88e-04	172	37	3	2214cc37d7c21b868768d3f74ca4631d339d37b3
ToppCell	facs-Thymus-Flowthrough-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HLA-DQA1 HARBI1 FCMR	3.88e-04	172	37	3	438d2e7f1897668a14d85ca70722e5d0102606dc
ToppCell	15-Airway-Immune-Hematopoietic,_B_Cells\|Airway / Age, Tissue, Lineage and Cell class	HLA-DQA1 HLA-DQA2 FCMR	3.88e-04	172	37	3	36f2444754f1e37683cb812380e6b05b356f9f4a
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HLA-DQA1 HLA-DQA2 FCMR	3.88e-04	172	37	3	07620728a6cdeea805e1365e588be096c17a370c
ToppCell	Leuk-UTI-Myeloid-cDC1\|Leuk-UTI / Disease, Lineage and Cell Type	FNIP2 HLA-DQA1 HLA-DQA2	3.94e-04	173	37	3	226bb8d881f32d65c60f5e4c034c6d465f8e7ba5
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage\|368C / Donor, Lineage, Cell class and subclass (all cells)	GPNMB HLA-DQA1 HLA-DQA2	3.94e-04	173	37	3	bba8265a58f8f5659dc7b9da2fe27b15033fce34
Drug	Eserine sulfate, physostigmine sulfate [64-47-1]; Up 200; 6.2uM; PC3; HT_HG-U133A	CUL9 XDH AFF1 ACAN AFF4 FCMR	7.67e-07	199	37	6	5749_UP
Drug	Pimethixene maleate [13187-06-9]; Up 200; 9.8uM; MCF7; HT_HG-U133A	CRISPLD2 EPOR XDH AFF1 ACAN	1.53e-05	195	37	5	7468_UP
Drug	Thioproperazine dimesylate [2347-80-0]; Up 200; 6.2uM; PC3; HT_HG-U133A	GIT2 SLC2A8 ACAN AFF4 FCMR	1.57e-05	196	37	5	2073_UP
Drug	Quinidine hydrochloride monohydrate [6151-40-2]; Up 200; 10.6uM; PC3; HT_HG-U133A	CRISPLD2 GPNMB KIF13A ACAN FCMR	1.57e-05	196	37	5	5793_UP
Disease	uveitis (implicated_via_orthology)	HLA-DQA1 HLA-DQA2	8.35e-05	11	37	2	DOID:13141 (implicated_via_orthology)
Disease	Nerve Degeneration	EPOR XDH SIRT1	1.56e-04	83	37	3	C0027746
Disease	type 2 diabetes mellitus (implicated_via_orthology)	AFF1 SIRT1 AFF4	3.12e-04	105	37	3	DOID:9352 (implicated_via_orthology)
Disease	vitiligo (is_implicated_in)	NLRP1 HLA-DQA1	3.16e-04	21	37	2	DOID:12306 (is_implicated_in)
Disease	chronic hepatitis B virus infection	HLA-DQA1 HLA-DQA2	4.15e-04	24	37	2	EFO_0004239
Disease	mosquito bite reaction itch intensity measurement	HLA-DQA1 HLA-DQA2 AFF4	5.69e-04	129	37	3	EFO_0008377
Disease	primary biliary cirrhosis	ATG5 HLA-DQA1 SPEF2	6.22e-04	133	37	3	EFO_1001486
Disease	chronic rhinosinusitis	HLA-DQA1 SPEF2	8.37e-04	34	37	2	EFO_1000024
Disease	multiple myeloma (is_marker_for)	XDH NOTCH2	9.38e-04	36	37	2	DOID:9538 (is_marker_for)
Disease	cholesteryl esters to total lipids in medium LDL percentage	AFF1 HLA-DQA1	9.91e-04	37	37	2	EFO_0022252
Disease	triglycerides in large LDL measurement	AFF1 HLA-DQA1	1.34e-03	43	37	2	EFO_0022319
Disease	biliary liver cirrhosis	HLA-DQA1 SPEF2	1.40e-03	44	37	2	EFO_0004267
Disease	total lipids in very small VLDL measurement	AFF1 HLA-DQA1	1.46e-03	45	37	2	EFO_0022156
Disease	Heart Diseases	XDH SIRT1	1.53e-03	46	37	2	C0018799
Disease	free cholesterol in very small VLDL measurement	AFF1 HLA-DQA1	1.60e-03	47	37	2	EFO_0022275
Disease	alcohol use disorder (implicated_via_orthology)	SIRT1 NOTCH2 RHBDL3	1.87e-03	195	37	3	DOID:1574 (implicated_via_orthology)
Disease	phospholipids in very small VLDL measurement	AFF1 HLA-DQA1	1.88e-03	51	37	2	EFO_0022300
Disease	polyunsaturated fatty acids to monounsaturated fatty acids ratio	AFF1 HLA-DQA1	1.88e-03	51	37	2	EFO_0022302
Disease	omega-6 polyunsaturated fatty acid measurement	AFF1 HLA-DQA1 FER1L4	1.93e-03	197	37	3	EFO_0005680
Disease	atopic asthma	ATG5 HLA-DQA1 SPEF2	1.98e-03	199	37	3	EFO_0010638
Disease	triglycerides in HDL measurement	AFF1 HLA-DQA1	2.03e-03	53	37	2	EFO_0022317
Disease	cholesterol in small VLDL measurement	AFF1 HLA-DQA1	2.03e-03	53	37	2	EFO_0022228
Disease	free cholesterol to total lipids in small LDL percentage	AFF1 HLA-DQA1	2.03e-03	53	37	2	EFO_0022286
Disease	lymphocyte count	FNIP2 ATG5 AFF1 ZNF469 HLA-DQA1 SPEF2 NOTCH2	2.03e-03	1464	37	7	EFO_0004587
Disease	Malignant neoplasm of breast	EPOR XDH AFF1 GPNMB SIRT1 NOTCH2	2.03e-03	1074	37	6	C0006142
Disease	triglycerides in medium HDL measurement	AFF1 HLA-DQA1	2.10e-03	54	37	2	EFO_0022321
Disease	total lipids in medium VLDL	AFF1 HLA-DQA1	2.10e-03	54	37	2	EFO_0022153
Disease	triglycerides in medium VLDL measurement	AFF1 HLA-DQA1	2.18e-03	55	37	2	EFO_0022155

Protein segments in the cluster

Peptide	Gene	Start	Entry
TDVLMPVPWPESSLI	GPNMB	396	Q14956
LKHTPWPPTLLQMVE	GIT2	51	Q14161
HGIEPMLETPLQWLS	ATG5	241	Q9H1Y0
EELHMPITVIWGVSP	DISP1	781	Q96F81
KHWEPEIPAPMSELT	HLA-DQA1	201	P01909
VDEILKEMTHSWPPP	AFF4	316	Q9UHB7
KMESLVVSWQPPPHP	IGDCC4	641	Q8TDY8
LSRLHPVPVPADWMN	NOTCH2	2241	Q04721
LKHWEPEIPAPMSEL	HLA-DQA2	201	P01906
HMWIDIFPQDVPAPP	FER1L4	1466	A9Z1Z3
RTWLMTPLHIPETPA	HARBI1	231	Q96MB7
PTSTAVLMPWIHELP	NLRP1	111	Q9C000
PIPEENHVWLQPRVM	CRISPLD2	256	Q9H0B8
HIAMKPPVRVVEGPW	GDPD4	516	Q6W3E5
VHMLWTPAPPDLTLG	PGGHG	176	Q32M88
TVQTVTWPDMELPLP	ACAN	371	P16112
HLVPMVAPDELPTWI	PKD1L2	1226	Q7Z442
PKPEITWEMPDHSLL	IGSF10	2556	Q6WRI0
LAWVPTVMPVDHPPI	FNIP2	446	Q9P278
PWMAPEVIQSLPVSE	MAP3K20	171	Q9NYL2
HVVLRWLPPPETPMT	EPOR	161	P19235
PEAMVLPWHEVLEPC	CUL9	1026	Q8IWT3
RPTPTWLEEQHIPPM	INCA1	51	Q0VD86
ADWIPPPGMETHIPV	KIF13A	1161	Q9H1H9
VTSMPWPIPLEEELL	SPEF2	1541	Q9C093
APLEMTVWVPKLPLH	TMEM132E	526	Q6IEE7
PPPWFMITVTLLEVA	RHBDL3	161	P58872
PIPWLLMSEIFPLHV	SLC2A8	391	Q9NY64
PPPELDDMTLWQIVI	SIRT1	211	Q96EB6
VEEILKEMTHSWPPP	AFF1	356	P51825
VAFPPEVVTDWHMLP	TAS1R3	701	Q7RTX0
EWMIVTVLPVPPLSV	POLR2A	246	P24928
EEQPMPETPKWFHLP	FCMR	131	O60667
PMIVCPAWIPELNSV	XDH	276	P47989
PEAIPELHMVPAAWR	ZNF469	2956	Q96JG9
MAIPKHSLSPVPWEE	ZSCAN22	1	P10073
PWNVKRHEMVTEPPV	ZNF98	71	A6NK75