Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionenzyme activator activity

RALGAPA1 PPP2R5B MYO9A ARHGEF12 TBC1D22B CCNYL3 ARHGAP11A FAM20A ARHGAP11B

2.67e-05656499GO:0008047
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

RALGAPA1 MYO9A RAPGEF4 ARHGEF12 TBC1D22B ARHGAP11A ARHGAP11B PLCE1

2.95e-05507498GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

RALGAPA1 MYO9A RAPGEF4 ARHGEF12 TBC1D22B ARHGAP11A ARHGAP11B PLCE1

2.95e-05507498GO:0030695
GeneOntologyMolecularFunctionGTPase activator activity

RALGAPA1 MYO9A ARHGEF12 TBC1D22B ARHGAP11A ARHGAP11B

5.95e-05279496GO:0005096
GeneOntologyMolecularFunctionenzyme regulator activity

RALGAPA1 PPP2R5B MYO9A RAPGEF4 ARHGEF12 TBC1D22B PPP6R1 CCNYL3 ARHGAP11A FAM20A ARHGAP11B PLCE1

1.23e-0414184912GO:0030234
GeneOntologyMolecularFunctionmolecular function activator activity

RALGAPA1 SEMA6C PPP2R5B MYO9A ARHGEF12 TBC1D22B CCNYL3 ARHGAP11A FAM20A ARHGAP11B

7.00e-0412334910GO:0140677
DomainRA

MYO9A RAPGEF4 PLCE1

1.14e-0436493PF00788
DomainUbiquitin-rel_dom

MYO7A MYO9A RAPGEF4 PLCE1 VCPIP1

1.18e-04184495IPR029071
DomainRA_dom

MYO9A RAPGEF4 PLCE1

1.57e-0440493IPR000159
DomainARM-type_fold

RALGAPA1 NCAPD3 PPP2R5B ARMC9 PPP6R1 RYR3

2.48e-04339496IPR016024
DomainRhoGAP

MYO9A ARHGAP11A ARHGAP11B

5.76e-0462493SM00324
DomainRhoGAP

MYO9A ARHGAP11A ARHGAP11B

6.03e-0463493PF00620
DomainRHOGAP

MYO9A ARHGAP11A ARHGAP11B

6.32e-0464493PS50238
DomainRhoGAP_dom

MYO9A ARHGAP11A ARHGAP11B

6.32e-0464493IPR000198
Domain-

MYO9A ARHGAP11A ARHGAP11B

6.32e-04644931.10.555.10
DomainRho_GTPase_activation_prot

MYO9A ARHGAP11A ARHGAP11B

1.59e-0388493IPR008936
DomainRASGEF

RAPGEF4 PLCE1

2.11e-0326492PS00720
DomainRASGEF_CAT

RAPGEF4 PLCE1

2.62e-0329492PS50009
DomainRasGEF

RAPGEF4 PLCE1

2.80e-0330492PF00617
Domain-

RAPGEF4 PLCE1

2.80e-03304921.10.840.10
DomainRas_GEF_dom

RAPGEF4 PLCE1

2.80e-0330492IPR023578
DomainRASGEF_cat_dom

RAPGEF4 PLCE1

2.80e-0330492IPR001895
DomainRasGEF

RAPGEF4 PLCE1

2.80e-0330492SM00147
DomainRA

MYO9A PLCE1

2.99e-0331492SM00314
DomainRA

MYO9A PLCE1

4.24e-0337492PS50200
DomainMyosin_head_motor_dom

MYO7A MYO9A

4.46e-0338492IPR001609
DomainMYOSIN_MOTOR

MYO7A MYO9A

4.46e-0338492PS51456
DomainMyosin_head

MYO7A MYO9A

4.46e-0338492PF00063
DomainMYSc

MYO7A MYO9A

4.46e-0338492SM00242
Pubmed

Analysis of a new allele of limb deformity (ld) reveals tissue- and age-specific transcriptional effects of the Ld Global Control Region.

ARHGAP11A ARHGAP11B RYR3

2.33e-07950317554679
Pubmed

A single splice site mutation in human-specific ARHGAP11B causes basal progenitor amplification.

ARHGAP11A ARHGAP11B

2.03e-06250227957544
Pubmed

Protooncogenic Role of ARHGAP11A and ARHGAP11B in Invasive Ductal Carcinoma: Two Promising Breast Cancer Biomarkers.

ARHGAP11A ARHGAP11B

2.03e-06250238046902
Pubmed

Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans.

RAPGEF4 PLCE1

2.03e-06250221478675
Pubmed

ArhGAP11A mediates amyloid-β generation and neuropathology in an Alzheimer's disease-like mouse model.

ARHGAP11A ARHGAP11B

2.03e-06250237302068
Pubmed

Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke.

RAPGEF4 PLCE1

6.07e-06350225103224
Pubmed

The Epac-Phospholipase Cε Pathway Regulates Endocannabinoid Signaling and Cocaine-Induced Disinhibition of Ventral Tegmental Area Dopamine Neurons.

RAPGEF4 PLCE1

6.07e-06350228209735
Pubmed

Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.

RAPGEF4 PLCE1

1.21e-05450221041529
Pubmed

Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis.

ARHGAP11A ARHGAP11B

1.21e-05450231883789
Pubmed

Subcellular mRNA localization and local translation of Arhgap11a in radial glial progenitors regulates cortical development.

ARHGAP11A ARHGAP11B

1.21e-05450236924763
Pubmed

Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosis.

RAPGEF4 TRAM2

2.02e-05550212401793
Pubmed

Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells.

ARHGEF12 PLCE1

3.03e-05650216565089
Pubmed

Tails of unconventional myosins.

MYO7A MYO9A

4.23e-05750211212352
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

NCAPD3 HYOU1 KIF1A DNAJC16 HS2ST1 PPP6R1 ZW10 VCPIP1

5.51e-0594250831073040
Pubmed

A 3-Mb map of a large Segmental duplication overlapping the alpha7-nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14.

ARHGAP11A ARHGAP11B

5.64e-05850211829490
Pubmed

A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein.

TTC9C FAM83H PLCE1

9.49e-056150319875381
Pubmed

LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.

SFMBT1 TBC1D31 MYO7A RYR3

1.02e-0416850430631154
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

RALGAPA1 SEMA6C NCAPD3 HS2ST1 ARHGAP11A ARHGAP11B

1.08e-0452950614621295
Pubmed

Functional synergy of a human-specific and an ape-specific metabolic regulator in human neocortex development.

ARHGAP11A ARHGAP11B

1.10e-041150238658571
Pubmed

Expression of human-specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility.

ARHGAP11A ARHGAP11B

1.82e-041450233938018
Pubmed

Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types.

MYO7A MYO9A

1.82e-04145028022818
Pubmed

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.

NCAPD3 DPP9 DNAJC16 NLRX1 PPP6R1 FAM83H

2.26e-0460650636538041
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

MYO9A ARHGEF12 PPP6R1 VCPIP1

2.35e-0420950436779422
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DNAJC16 ARHGEF12 PPP6R1 PLCE1 VCPIP1

2.94e-0440750512693553
Pubmed

Mfrp, a gene encoding a frizzled related protein, is mutated in the mouse retinal degeneration 6.

HYOU1 NLRX1

3.05e-041850212140190
Pubmed

Transcriptional fates of human-specific segmental duplications in brain.

ARHGAP11A ARHGAP11B

3.41e-041950230228200
Pubmed

Transcriptomic analysis and novel insights into lens fibre cell differentiation regulated by Gata3.

ATP10D RYR3

3.41e-041950231847788
Pubmed

A germline-specific class of small RNAs binds mammalian Piwi proteins.

UNC119B DNAJC16 TRAM2 GGA1 FAM83H

4.65e-0445050516751776
Pubmed

Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

SEMA6C ARMC9 VCPIP1

4.99e-0410750311347906
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

TBC1D31 HYOU1 TBC1D22B VCPIP1

5.60e-0426350434702444
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

RALGAPA1 TBC1D31 HYOU1 DNAJC16 RNF213 VCPIP1

6.20e-0473350634672954
Pubmed

An Interaction Landscape of Ubiquitin Signaling.

KIF1A RNF213 GGA1 MOB4 VCPIP1

6.29e-0448150528190767
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

KIF1A LGALSL MYO7A RNF213 PPP6R1 ARHGAP11A

6.33e-0473650629676528
Pubmed

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.

ARHGEF12 ARMC9 RYR3 VCPIP1

7.46e-0428450429459677
Pubmed

Novel genes differentially expressed in cortical regions during late neurogenesis.

PPP2R5B TBC1D22B

7.48e-042850217614941
Pubmed

The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.

ARHGEF12 PPP6R1 MOB4

7.85e-0412550329467281
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

RALGAPA1 HYOU1 MYO7A MYO9A RAPGEF4 PHYHIP ARHGEF12 MOB4

9.27e-04143150837142655
Pubmed

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.

PPP2R5B HYOU1 MYO9A PPP6R1 MOB4

1.37e-0357350528330616
CytobandEnsembl 112 genes in cytogenetic band chr11q23

HYOU1 NLRX1 ARHGEF12 ZW10

9.94e-05220504chr11q23
CytobandEnsembl 112 genes in cytogenetic band chr15q13

ARHGAP11A ARHGAP11B RYR3

1.82e-04100503chr15q13
Cytoband15q13.2

ARHGAP11A ARHGAP11B

2.41e-042150215q13.2
Cytoband1p22.3

RPF1 HS2ST1

2.65e-04225021p22.3
Cytoband1p36.11

PIGV RHCE

2.53e-03685021p36.11
Cytoband11q23.3

NLRX1 ARHGEF12

3.31e-037850211q23.3
GeneFamilyRho GTPase activating proteins|BCH domain containing

ARHGAP11A ARHGAP11B

4.21e-0350352721
ToppCellPND01-03-samps-Mesenchymal-Matrix_fibroblast-matrix_-_mature_3|PND01-03-samps / Age Group, Lineage, Cell class and subclass

SEMA6C SCN1B FAM20A ZKSCAN5

1.57e-051374949bfdbc102cdd861996b3c4eac35b606be8af97eb
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NCAPD3 SCN1B TBC1D22B ATP10D

2.18e-0514949465778f19599b4955c0a16f0121237656449431fb
ToppCellNS-moderate-d_07-13-Epithelial-FOXN4+|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

RAPGEF4 PHYHIP TTC6 PLCE1

2.68e-05157494410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCellPND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DPP9 ZW10 ZKSCAN5 VCPIP1

3.49e-0516849408f6e171a1ea5cf65149744296d0fcd6c7b9684e
ToppCell11.5-Distal-Mesenchymal-Mesenchyme_SERPINF1-high|Distal / Age, Tissue, Lineage and Cell class

NAA60 PHYHIP FAM20A BDKRB1

3.91e-051734946989c9cebcd81eccceac7e5a86152676ee959386
ToppCellCOVID-19-kidney-Podocyte|kidney / Disease (COVID-19 only), tissue and cell type

PHYHIP TRAM2 RYR3 PLCE1

4.86e-05183494fb5e2a31b560126e1c04a386c24c365901c60ad7
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PHYHIP ARHGEF12 RYR3 PLCE1

4.86e-051834943c516fe5083f02bad1f464ed284010b4131a833c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PHYHIP ARHGEF12 RYR3 PLCE1

4.86e-051834949c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PHYHIP TRAM2 RYR3 PLCE1

5.07e-05185494b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PHYHIP TRAM2 RYR3 PLCE1

5.07e-051854949197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PHYHIP TRAM2 RYR3 PLCE1

5.07e-05185494ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCell343B-Lymphocytic-ILC-ILC-1|343B / Donor, Lineage, Cell class and subclass (all cells)

TBC1D31 DPP9 MYO7A GGA1

5.40e-051884948f6b45ad82bde65e044d17f0edbc3db90d457915
ToppCellAdult|World / Lineage, Cell type, age group and donor

DPP9 RNF213 FAM20A GGA1

5.51e-051894945cd285bfad973125d46d704fec18b21266a63379
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-1|TCGA-Endometrium / Sample_Type by Project: Shred V9

NCAPD3 LGALSL HS2ST1 ZW10

5.98e-05193494c2673d86f7d7b849788036032a93a6d136a70040
ToppCellBronchial-10x5prime-Stromal-Mesofibroblastic-Mesothelia|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

TMEM45A SCN1B PHYHIP BDKRB1

6.47e-0519749426888af95a7cc082a1f1218af35b1f07cb9436ed
ToppCellBronchial-10x5prime-Stromal-Mesofibroblastic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

TMEM45A SCN1B PHYHIP BDKRB1

6.47e-05197494438de7f0d35d81d5f5e41dcef7b2c54b6da03df4
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW19-Stem_cells-Stem_cells|GW19 / Sample Type, Dataset, Time_group, and Cell type.

NCAPD3 ARHGAP11A ARHGAP11B ATP10D

6.60e-0519849450f236ab7ef6f00721f6cd714e3eee183077beeb
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW19-Stem_cells|GW19 / Sample Type, Dataset, Time_group, and Cell type.

NCAPD3 ARHGAP11A ARHGAP11B ATP10D

6.60e-05198494dc0c6189ff9dd76675f63acf1cbc7dda60e75f3f
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SCN1B RAPGEF4 ARHGEF12 RNF213

6.86e-0520049489821a264e872ed53e08e9d3609d5cc5c314503e
DiseaseAmelogenesis imperfecta

FAM20A FAM83H

3.33e-0417472cv:C0002452
Diseasemigraine disorder, systolic blood pressure

RNF213 PLCE1

3.74e-0418472EFO_0006335, MONDO_0005277
DiseaseLewy body dementia, Lewy body dementia measurement

MYO7A TTC6

7.88e-0426472EFO_0006792, EFO_0006799
Diseasebody fat percentage

RALGAPA1 HYOU1 TRAM2 ZKSCAN5 PLCE1

1.05e-03488475EFO_0007800
DiseaseMoyamoya disease

RAPGEF4 RNF213

1.86e-0340472MONDO_0016820
Diseaseuric acid measurement

SFMBT1 PPP2R5B MYO9A DNAJC16 ZKSCAN5

2.78e-03610475EFO_0004761
Diseaseaspartate aminotransferase measurement

MYO7A RNF213 ARMC9 ACOX2 TTC6 PLCE1

2.99e-03904476EFO_0004736

Protein segments in the cluster

PeptideGeneStartEntry
NHIFLRFIYEFEHFN

PPP2R5B

236

Q15173
AFHFLAVSLLEFFQH

ACOX2

356

Q99424
YHFFAFLEFLFQVQA

BDKRB1

266

P46663
LFEQFHRAANLYFLF

ATP10D

91

Q9P241
IFLEFHQFFLDRSAH

ARHGEF12

421

Q9NZN5
HTVHVLRYFFNFLRN

ARHGAP11B

166

Q3KRB8
RVFVDGHQLFDFYHR

LGALSL

136

Q3ZCW2
AINFYENRDFKQHHY

NAA60

146

Q9H7X0
SFAQKLEFYLHIHFA

ARMC9

91

Q7Z3E5
QQREYRFRHFHENFY

DNAJC16

106

Q9Y2G8
RFRHFHENFYFDESF

DNAJC16

111

Q9Y2G8
HENFYFDESFFHFPF

DNAJC16

116

Q9Y2G8
TVYDQHGFRILFHFA

GGA1

516

Q9UJY5
LDHLFFHYEFQNQRF

NLRX1

676

Q86UT6
YLGHFHLDVFFQEEF

PANX3

226

Q96QZ0
LANDHDLYFLFSFLH

CCNYL3

186

P0C7X3
VITFNRYSHDFNFHI

HYOU1

481

Q9Y4L1
FLDENVHFFHTNFLV

DPP9

806

Q86TI2
FRFQTSHFHRDQLYQ

FAM83H

441

Q6ZRV2
YADIFCQFNFIHRHD

KIF1A

1016

Q12756
HTVHVLRYFFNFLRN

ARHGAP11A

166

Q6P4F7
QEHHFQDKYLFYRFL

RAPGEF4

276

Q8WZA2
VHNHFRRYEVEYLQF

TBC1D22B

391

Q9NU19
DFEFFFHHRNNLDIN

TBC1D31

626

Q96DN5
IFSHAYFHHRQIFDE

MOB4

166

Q9Y3A3
FQHYRSVFYSFEEQH

NBPF9

1066

P0DPF3
NEQFLFHVHFEDLVF

PLCE1

1921

Q9P212
FFYFIDFQRHNAEIA

FAM20A

251

Q96MK3
FYEFALEQFQFIRAH

HS2ST1

316

Q7LGA3
RFSVFYRNHHKEYFQ

PHYHIP

136

Q92561
DFRRFVAHFYLEHNA

PGBD1

791

Q96JS3
FIECIFHFNNYEKHE

NCAPD3

1056

P42695
FLFIAEHGYLYEHNF

PIGV

71

Q9NUD9
EYFHRQRHNSFADFL

RNF213

3286

Q63HN8
FHNQRDYIFFRFHRY

RPF1

281

Q9H9Y2
IYFHHRQFSQASDYF

TTC6

391

Q86TZ1
IDLKQFFDQHFSHIY

RALGAPA1

41

Q6GYQ0
FFDQHFSHIYYVFFE

RALGAPA1

46

Q6GYQ0
FNTDYHMNLRHFYVF

RHCE

161

P18577
HYNNFFFAAHLLDIA

RYR3

4636

Q15413
FLFHTARLFYFADEN

TRAM2

226

Q15035
CHVYRLLFFENYEHN

SCN1B

121

Q07699
HYFREHLLKNFDFDF

UNC119B

176

A6NIH7
FVQALEHGDHVYFFF

SEMA6C

226

Q9H3T2
VAFFHLQDYDQARHY

TTC9C

116

Q8N5M4
FQQHLARYQALFHDF

VCPIP1

246

Q96JH7
MLDLFFHYVFNNFLH

PPP6R1

386

Q9UPN7
HHIERIKFAFYEQFA

SFMBT1

851

Q9UHJ3
LFVEAFIFYNHTHGR

TMEM45A

131

Q9NWC5
FETFYQRFRHFQYHE

ZKSCAN5

46

Q9Y2L8
VQLFYSVRNIFHLFH

ZW10

506

O43264
FANEHLQQFFVRHVF

MYO7A

456

Q13402
FANERLQHYFNQHIF

MYO9A

556

B2RTY4