Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	NALCN SCN4A SCN7A	5.77e-05	26	58	3	GO:0005248
GeneOntologyMolecularFunction	monoatomic ion channel activity	CLCN4 NALCN SCN4A SCN7A CHRFAM7A CHRNA7 GABRA6	3.54e-04	459	58	7	GO:0005216
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCA1 ABCA13 ABCA9	3.90e-04	49	58	3	GO:0140359
GeneOntologyMolecularFunction	sodium channel activity	NALCN SCN4A SCN7A	4.65e-04	52	58	3	GO:0005272
GeneOntologyMolecularFunction	Roundabout binding	SLIT1 LRTM1	5.37e-04	12	58	2	GO:0048495
GeneOntologyMolecularFunction	co-SMAD binding	USP9X USP9Y	5.37e-04	12	58	2	GO:0070410
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	CHRFAM7A CHRNA7 GABRA6	6.09e-04	57	58	3	GO:1904315
GeneOntologyMolecularFunction	acetylcholine binding	CHRFAM7A CHRNA7	6.34e-04	13	58	2	GO:0042166
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	CHRFAM7A CHRNA7 GABRA6	7.08e-04	60	58	3	GO:0099529
GeneOntologyMolecularFunction	channel activity	CLCN4 NALCN SCN4A SCN7A CHRFAM7A CHRNA7 GABRA6	7.86e-04	525	58	7	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CLCN4 NALCN SCN4A SCN7A CHRFAM7A CHRNA7 GABRA6	7.95e-04	526	58	7	GO:0022803
GeneOntologyMolecularFunction	chloride channel regulator activity	CHRFAM7A CHRNA7	8.50e-04	15	58	2	GO:0017081
GeneOntologyMolecularFunction	transmitter-gated channel activity	CHRFAM7A CHRNA7 GABRA6	8.94e-04	65	58	3	GO:0022835
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity	CHRFAM7A CHRNA7 GABRA6	8.94e-04	65	58	3	GO:0022824
GeneOntologyMolecularFunction	adenylate cyclase binding	CHRFAM7A CHRNA7	9.69e-04	16	58	2	GO:0008179
GeneOntologyMolecularFunction	acetylcholine-gated monoatomic cation-selective channel activity	CHRFAM7A CHRNA7	1.10e-03	17	58	2	GO:0022848
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DYNC2H1 DNAH8	1.23e-03	18	58	2	GO:0008569
GeneOntologyMolecularFunction	toxic substance binding	CHRFAM7A CHRNA7	1.23e-03	18	58	2	GO:0015643
GeneOntologyMolecularFunction	postsynaptic neurotransmitter receptor activity	CHRFAM7A CHRNA7 GABRA6	1.35e-03	75	58	3	GO:0098960
GeneOntologyMolecularFunction	extracellular ligand-gated monoatomic ion channel activity	CHRFAM7A CHRNA7 GABRA6	1.46e-03	77	58	3	GO:0005230
GeneOntologyMolecularFunction	ATP hydrolysis activity	ABCA1 DYNC2H1 ABCA13 CHTF18 DNAH8 ABCA9	1.72e-03	441	58	6	GO:0016887
GeneOntologyMolecularFunction	ATP-dependent activity	ABCA1 EP400 DYNC2H1 ABCA13 CHTF18 DNAH8 ABCA9	1.94e-03	614	58	7	GO:0140657
GeneOntologyMolecularFunction	transmembrane transporter activity	ABCA1 CLCN4 NALCN ABCA13 SCN4A SCN7A CHRFAM7A ABCA9 CHRNA7 GABRA6	1.95e-03	1180	58	10	GO:0022857
GeneOntologyMolecularFunction	acetylcholine receptor activity	CHRFAM7A CHRNA7	2.02e-03	23	58	2	GO:0015464
GeneOntologyMolecularFunction	phosphatidylinositol kinase activity	PI4K2A ATM	2.58e-03	26	58	2	GO:0052742
GeneOntologyMolecularFunction	gated channel activity	CLCN4 SCN7A CHRFAM7A CHRNA7 GABRA6	2.82e-03	334	58	5	GO:0022836
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DYNC2H1 DNAH8	2.99e-03	28	58	2	GO:0051959
GeneOntologyMolecularFunction	neurotransmitter receptor activity	CHRFAM7A CHRNA7 GABRA6	3.08e-03	100	58	3	GO:0030594
GeneOntologyMolecularFunction	monoatomic cation channel activity	NALCN SCN4A SCN7A CHRFAM7A CHRNA7	3.16e-03	343	58	5	GO:0005261
GeneOntologyMolecularFunction	transporter activity	ABCA1 CLCN4 NALCN ABCA13 SCN4A SCN7A CHRFAM7A ABCA9 CHRNA7 GABRA6	3.70e-03	1289	58	10	GO:0005215
GeneOntologyMolecularFunction	ATPase binding	ABCA1 CHRFAM7A CHRNA7	3.83e-03	108	58	3	GO:0051117
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ABCA1 ABCA13 ABCA9	3.93e-03	109	58	3	GO:0042626
GeneOntologyMolecularFunction	dynein intermediate chain binding	DYNC2H1 DNAH8	5.17e-03	37	58	2	GO:0045505
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	VRK2 CRIM1 CDK13 PI4K2A ATM PTGES3 FGGY PRPS1L1	5.49e-03	938	58	8	GO:0016772
GeneOntologyMolecularFunction	lipid kinase activity	PI4K2A ATM	6.32e-03	41	58	2	GO:0001727
GeneOntologyMolecularFunction	kinase activity	VRK2 CRIM1 CDK13 PI4K2A ATM FGGY PRPS1L1	6.44e-03	764	58	7	GO:0016301
GeneOntologyMolecularFunction	excitatory extracellular ligand-gated monoatomic ion channel activity	CHRFAM7A CHRNA7	6.94e-03	43	58	2	GO:0005231
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	CLCN4 NALCN SCN4A SCN7A CHRFAM7A CHRNA7 GABRA6	7.84e-03	793	58	7	GO:0015075
GeneOntologyBiologicalProcess	positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure	CHRFAM7A CHRNA7	7.50e-06	2	57	2	GO:0001988
GeneOntologyBiologicalProcess	baroreceptor response to decreased systemic arterial blood pressure	CHRFAM7A CHRNA7	2.25e-05	3	57	2	GO:0001982
GeneOntologyBiologicalProcess	cilium assembly	CLCN4 DYNC2H1 USP9X TBC1D5 ADAMTS16 CFAP43 DNAH8 WDR44	2.84e-05	444	57	8	GO:0060271
GeneOntologyBiologicalProcess	generation of ovulation cycle rhythm	CHRFAM7A CHRNA7	4.49e-05	4	57	2	GO:0060112
GeneOntologyBiologicalProcess	cytosolic ciliogenesis	USP9X WDR44	4.49e-05	4	57	2	GO:0061824
GeneOntologyBiologicalProcess	cilium organization	CLCN4 DYNC2H1 USP9X TBC1D5 ADAMTS16 CFAP43 DNAH8 WDR44	4.65e-05	476	57	8	GO:0044782
GeneOntologyBiologicalProcess	sensory processing	CHRFAM7A CHRNA7	7.46e-05	5	57	2	GO:0050893
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback	CHRFAM7A CHRNA7	1.12e-04	6	57	2	GO:0001978
GeneOntologyBiologicalProcess	telomerase holoenzyme complex assembly	ATM PTGES3	1.12e-04	6	57	2	GO:1905323
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure by baroreceptor feedback	CHRFAM7A CHRNA7	2.08e-04	8	57	2	GO:0003025
GeneOntologyBiologicalProcess	synaptic transmission, cholinergic	NALCN CHRFAM7A CHRNA7	2.45e-04	44	57	3	GO:0007271
GeneOntologyBiologicalProcess	amyloid fibril formation	USP9X CHRFAM7A CHRNA7	2.61e-04	45	57	3	GO:1990000
GeneOntologyBiologicalProcess	positive regulation of CoA-transferase activity	CHRFAM7A CHRNA7	2.67e-04	9	57	2	GO:1905920
GeneOntologyBiologicalProcess	cilium movement involved in cell motility	DYNC2H1 CFAP43 CHRFAM7A DNAH8 CHRNA7	2.84e-04	210	57	5	GO:0060294
GeneOntologyBiologicalProcess	cilium or flagellum-dependent cell motility	DYNC2H1 CFAP43 CHRFAM7A DNAH8 CHRNA7	3.17e-04	215	57	5	GO:0001539
GeneOntologyBiologicalProcess	cilium-dependent cell motility	DYNC2H1 CFAP43 CHRFAM7A DNAH8 CHRNA7	3.17e-04	215	57	5	GO:0060285
GeneOntologyBiologicalProcess	regulation of CoA-transferase activity	CHRFAM7A CHRNA7	4.06e-04	11	57	2	GO:1905918
GeneOntologyBiologicalProcess	behavioral response to nicotine	CHRFAM7A CHRNA7	4.06e-04	11	57	2	GO:0035095
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection assembly	CLCN4 DYNC2H1 USP9X TBC1D5 ADAMTS16 CFAP43 DNAH8 WDR44	4.82e-04	670	57	8	GO:0120031
GeneOntologyBiologicalProcess	regulation of synapse structural plasticity	CHRFAM7A CHRNA7	4.86e-04	12	57	2	GO:0051823
GeneOntologyBiologicalProcess	cell projection assembly	CLCN4 DYNC2H1 USP9X TBC1D5 ADAMTS16 CFAP43 DNAH8 WDR44	5.58e-04	685	57	8	GO:0030031
GeneOntologyBiologicalProcess	regulation of synaptic transmission, dopaminergic	CHRFAM7A CHRNA7	5.74e-04	13	57	2	GO:0032225
GeneOntologyBiologicalProcess	neuronal action potential	SCN4A CHRFAM7A CHRNA7	7.06e-04	63	57	3	GO:0019228
GeneOntologyBiologicalProcess	cilium movement	DYNC2H1 CFAP43 CHRFAM7A DNAH8 CHRNA7	7.64e-04	261	57	5	GO:0003341
GeneOntologyBiologicalProcess	dendrite arborization	CHRFAM7A CHRNA7	7.70e-04	15	57	2	GO:0140059
GeneOntologyCellularComponent	spine apparatus membrane	CHRFAM7A CHRNA7	2.27e-05	3	58	2	GO:0098897
GeneOntologyCellularComponent	spine apparatus	CHRFAM7A CHRNA7	2.69e-04	9	58	2	GO:0097444
GeneOntologyCellularComponent	monoatomic ion channel complex	NALCN SCN4A SCN7A CHRFAM7A CHRNA7 GABRA6	6.15e-04	378	58	6	GO:0034702
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN4A SCN7A	1.00e-03	17	58	2	GO:0001518
GeneOntologyCellularComponent	acetylcholine-gated channel complex	CHRFAM7A CHRNA7	1.12e-03	18	58	2	GO:0005892
GeneOntologyCellularComponent	glycinergic synapse	CHRFAM7A CHRNA7	1.39e-03	20	58	2	GO:0098690
GeneOntologyCellularComponent	axolemma	CHRFAM7A CHRNA7	1.54e-03	21	58	2	GO:0030673
GeneOntologyCellularComponent	neuron projection membrane	CHRFAM7A CHRNA7 GABRA6	1.54e-03	82	58	3	GO:0032589
GeneOntologyCellularComponent	cholinergic synapse	CHRFAM7A CHRNA7	1.69e-03	22	58	2	GO:0098981
GeneOntologyCellularComponent	BLOC complex	PI4K2A HPS3	1.84e-03	23	58	2	GO:0031082
MousePheno	airway basal cell hyperplasia	CHRFAM7A CHRNA7	9.24e-06	2	43	2	MP:0011115
MousePheno	abnormal airway basal cell differentiation	CHRFAM7A CHRNA7	9.24e-06	2	43	2	MP:0011114
MousePheno	abnormal airway basal cell morphology	CHRFAM7A CHRNA7	9.24e-06	2	43	2	MP:0011113
MousePheno	abnormal nicotine-mediated receptor currents	CHRFAM7A CHRNA7	5.52e-05	4	43	2	MP:0009475
MousePheno	failure of neuromuscular synapse presynaptic differentiation	CHRFAM7A CHRNA7	1.38e-04	6	43	2	MP:0001054
Domain	AAA+_ATPase	ABCA1 DYNC2H1 ABCA13 CHTF18 DNAH8 ABCA9	5.51e-06	144	58	6	IPR003593
Domain	AAA	ABCA1 DYNC2H1 ABCA13 CHTF18 DNAH8 ABCA9	5.51e-06	144	58	6	SM00382
Domain	ABC_A	ABCA1 ABCA13 ABCA9	6.13e-06	12	58	3	IPR026082
Domain	Coact_PPARg	FAM120A FAM120C	5.66e-05	4	58	2	IPR026784
Domain	DHC_N1	DYNC2H1 DNAH8	2.62e-04	8	58	2	PF08385
Domain	Dynein_heavy_dom-1	DYNC2H1 DNAH8	2.62e-04	8	58	2	IPR013594
Domain	Neurotransmitter_ion_chnl_CS	CHRFAM7A CHRNA7 GABRA6	3.68e-04	45	58	3	IPR018000
Domain	Neur_chan_memb	CHRFAM7A CHRNA7 GABRA6	3.92e-04	46	58	3	PF02932
Domain	Neur_chan_LBD	CHRFAM7A CHRNA7 GABRA6	4.18e-04	47	58	3	PF02931
Domain	NEUROTR_ION_CHANNEL	CHRFAM7A CHRNA7 GABRA6	4.18e-04	47	58	3	PS00236
Domain	Neurotrans-gated_channel_TM	CHRFAM7A CHRNA7 GABRA6	4.18e-04	47	58	3	IPR006029
Domain	-	CHRFAM7A CHRNA7 GABRA6	4.18e-04	47	58	3	2.70.170.10
Domain	Neur_channel	CHRFAM7A CHRNA7 GABRA6	4.18e-04	47	58	3	IPR006201
Domain	Neur_chan_lig-bd	CHRFAM7A CHRNA7 GABRA6	4.18e-04	47	58	3	IPR006202
Domain	Na_channel_asu	SCN4A SCN7A	4.20e-04	10	58	2	IPR001696
Domain	Na_trans_assoc	SCN4A SCN7A	4.20e-04	10	58	2	IPR010526
Domain	Na_trans_assoc	SCN4A SCN7A	4.20e-04	10	58	2	PF06512
Domain	ABC_tran	ABCA1 ABCA13 ABCA9	4.45e-04	48	58	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCA1 ABCA13 ABCA9	4.45e-04	48	58	3	PS50893
Domain	ABC_TRANSPORTER_1	ABCA1 ABCA13 ABCA9	4.73e-04	49	58	3	PS00211
Domain	ABC_transporter-like	ABCA1 ABCA13 ABCA9	5.02e-04	50	58	3	IPR003439
Domain	SCAN	ZNF449 ZSCAN32 ZNF483	7.01e-04	56	58	3	SM00431
Domain	Channel_four-helix_dom	NALCN SCN4A SCN7A	7.38e-04	57	58	3	IPR027359
Domain	-	NALCN SCN4A SCN7A	7.38e-04	57	58	3	1.20.120.350
Domain	SCAN_BOX	ZNF449 ZSCAN32 ZNF483	7.77e-04	58	58	3	PS50804
Domain	SCAN	ZNF449 ZSCAN32 ZNF483	7.77e-04	58	58	3	PF02023
Domain	SCAN_dom	ZNF449 ZSCAN32 ZNF483	7.77e-04	58	58	3	IPR003309
Domain	Retrov_capsid_C	ZNF449 ZSCAN32 ZNF483	8.17e-04	59	58	3	IPR008916
Domain	Dynein_heavy_chain_D4_dom	DYNC2H1 DNAH8	8.42e-04	14	58	2	IPR024317
Domain	Dynein_HC_stalk	DYNC2H1 DNAH8	8.42e-04	14	58	2	IPR024743
Domain	Dynein_heavy_dom-2	DYNC2H1 DNAH8	8.42e-04	14	58	2	IPR013602
Domain	PIN_domain-like	FAM120A FAM120C	8.42e-04	14	58	2	IPR029060
Domain	DHC_N2	DYNC2H1 DNAH8	8.42e-04	14	58	2	PF08393
Domain	MT	DYNC2H1 DNAH8	8.42e-04	14	58	2	PF12777
Domain	AAA_8	DYNC2H1 DNAH8	8.42e-04	14	58	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DYNC2H1 DNAH8	8.42e-04	14	58	2	IPR011704
Domain	AAA_5	DYNC2H1 DNAH8	8.42e-04	14	58	2	PF07728
Domain	DHC_fam	DYNC2H1 DNAH8	9.70e-04	15	58	2	IPR026983
Domain	Dynein_heavy_dom	DYNC2H1 DNAH8	9.70e-04	15	58	2	IPR004273
Domain	Dynein_heavy	DYNC2H1 DNAH8	9.70e-04	15	58	2	PF03028
Domain	PI3/4_kinase_cat_dom	PI4K2A ATM	1.40e-03	18	58	2	IPR000403
Domain	PI3_PI4_kinase	PI4K2A ATM	1.40e-03	18	58	2	PF00454
Domain	PI3_4_KINASE_3	PI4K2A ATM	1.40e-03	18	58	2	PS50290
Domain	PI3_4_KINASE_1	PI4K2A ATM	1.40e-03	18	58	2	PS00915
Domain	PI3_4_KINASE_2	PI4K2A ATM	1.40e-03	18	58	2	PS00916
Domain	IQ	IQCF5 SCN4A SCN7A	2.04e-03	81	58	3	SM00015
Domain	-	ABCA1 NWD1 EP400 DYNC2H1 ABCA13 CHTF18 DNAH8 ABCA9	2.04e-03	746	58	8	3.40.50.300
Domain	-	CHRFAM7A CHRNA7	2.30e-03	23	58	2	1.20.120.370
Domain	Acetylcholine_rcpt_TM	CHRFAM7A CHRNA7	2.30e-03	23	58	2	IPR027361
Domain	Cys-rich_flank_reg_C	LRIG3 SLIT1 LRTM1	2.76e-03	90	58	3	IPR000483
Domain	LRRCT	LRIG3 SLIT1 LRTM1	2.76e-03	90	58	3	SM00082
Domain	IQ_motif_EF-hand-BS	IQCF5 SCN4A SCN7A	2.76e-03	90	58	3	IPR000048
Domain	LRRNT	LRIG3 SLIT1 LRTM1	3.51e-03	98	58	3	IPR000372
Domain	LRRNT	LRIG3 SLIT1 LRTM1	3.51e-03	98	58	3	SM00013
Domain	LRRCT	LRIG3 SLIT1	4.43e-03	32	58	2	PF01463
Domain	P-loop_NTPase	ABCA1 NWD1 EP400 DYNC2H1 ABCA13 CHTF18 DNAH8 ABCA9	4.48e-03	848	58	8	IPR027417
Domain	Ion_trans_dom	NALCN SCN4A SCN7A	5.35e-03	114	58	3	IPR005821
Domain	Ion_trans	NALCN SCN4A SCN7A	5.35e-03	114	58	3	PF00520
Pubmed	Enhancing cognitive function in chronic TBI: The Role of α7 nicotinic acetylcholine receptor modulation.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	38070724
Pubmed	Inflammatory cytokines decrease the expression of nicotinic acetylcholine receptor during the cell maturation.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	19626424
Pubmed	Episodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit gene.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	17012698
Pubmed	Cholinergic Pathway Suppresses Pulmonary Innate Immunity Facilitating Pneumonia After Stroke.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	26451017
Pubmed	Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	34453977
Pubmed	Perinatal hypoxia-ischemia reduces α 7 nicotinic receptor expression and selective α 7 nicotinic receptor stimulation suppresses inflammation and promotes microglial Mox phenotype.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	24757672
Pubmed	Inhibition of pancreatic acinar mitochondrial thiamin pyrophosphate uptake by the cigarette smoke component 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	26999808
Pubmed	Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	27129924
Pubmed	Neuroprotection afforded by nicotine against oxygen and glucose deprivation in hippocampal slices is lost in alpha7 nicotinic receptor knockout mice.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	17291692
Pubmed	Sensorimotor gating and spatial learning in α7-nicotinic receptor knockout mice.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	23521765
Pubmed	Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	28258105
Pubmed	The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	19344760
Pubmed	Loss of α7nAChR enhances endothelial-to-mesenchymal transition after myocardial infarction via NF-κB activation.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	35926661
Pubmed	The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	17640819
Pubmed	Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	23431157
Pubmed	Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine Receptors.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	29114104
Pubmed	Autophagy is Involved in Neuroprotective Effect of Alpha7 Nicotinic Acetylcholine Receptor on Ischemic Stroke.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	33995108
Pubmed	E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	32552811
Pubmed	Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	24836856
Pubmed	Modulation of the MAPKs pathways affects Aβ-induced cognitive deficits in Alzheimer's disease via activation of α7nAChR.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	31904546
Pubmed	Studies of sperm from mutant mice suggesting that two neurotransmitter receptors are important to the zona pellucida-initiated acrosome reaction.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	15948184
Pubmed	Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	35678315
Pubmed	Age-Associated Tooth Loss and Oral Microbial Dysbiosis in a Mouse Genetic Model of Chronic Nicotine Exposure.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	33117372
Pubmed	Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	12628457
Pubmed	Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	25157794
Pubmed	Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	19615981
Pubmed	Splenic nerve denervation attenuates depression-like behaviors in Chrna7 knock-out mice via the spleen-gut-brain axis.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	38944290
Pubmed	Nicotine withdrawal-induced inattention is absent in alpha7 nAChR knockout mice.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	28243714
Pubmed	Mesenchymal Stem Cells or Interleukin-6 Improve Episodic Memory of Mice Lacking α7 Nicotinic Acetylcholine Receptors.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	31202708
Pubmed	Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	22246862
Pubmed	Stimulation of the α7 nicotinic acetylcholine receptor protects against sepsis by inhibiting Toll-like receptor via phosphoinositide 3-kinase activation.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	24298024
Pubmed	Lung eosinophilia induced by house dust mites or ovalbumin is modulated by nicotinic receptor α7 and inhibited by cigarette smoke.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	29975102
Pubmed	α7-nAChR Knockout Mice Decreases Biliary Hyperplasia and Liver Fibrosis in Cholestatic Bile Duct-Ligated Mice.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	29580318
Pubmed	Alpha-7 Nicotinic Receptor Dampens Murine Osteoblastic Response to Inflammation and Age-Related Osteoarthritis.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	35479080
Pubmed	[Activation of α7 nAChR improves white fat homeostasis and promotes beige adipogenesis and thermogenesis in obese mice].	CHRFAM7A CHRNA7	2.73e-06	2	58	2	38597441
Pubmed	Activation of Nicotinic Acetylcholine Receptors Decreases Apoptosis in Human and Female Murine Pancreatic Islets.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	27471776
Pubmed	Targeting α-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	22688057
Pubmed	α7 Nicotinic acetylcholine receptor agonist attenuates neuropathological changes associated with intracerebral hemorrhage in mice.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	22820264
Pubmed	Stimulation of α7-nAChRs coordinates autophagy and apoptosis signaling in experimental knee osteoarthritis.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	33953172
Pubmed	Different Effects of Nicotine and N-Stearoyl-ethanolamine on Episodic Memory and Brain Mitochondria of α7 Nicotinic Acetylcholine Receptor Knockout Mice.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	32028688
Pubmed	Genetic variation in CHRNA7 and CHRFAM7A is associated with nicotine dependence and response to varenicline treatment.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	30089821
Pubmed	Nicotinic acetylcholine receptor activation reduces skeletal muscle inflammation of mdx mice.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	20615555
Pubmed	Nicotine physical dependence in the mouse: involvement of the alpha7 nicotinic receptor subtype.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	15896732
Pubmed	Activation of α7 Nicotinic Acetylcholine Receptor Ameliorates Zymosan-Induced Acute Kidney Injury in BALB/c Mice.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	30429582
Pubmed	A transgenic mouse model reveals fast nicotinic transmission in hippocampal pyramidal neurons.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	21501254
Pubmed	α7-cholinergic receptor mediates vagal induction of splenic norepinephrine.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	21339364
Pubmed	Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	21368056
Pubmed	Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	24289814
Pubmed	Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	19949071
Pubmed	Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	1400473
Pubmed	Reversible inhibition of GABAA receptors by alpha7-containing nicotinic receptors on the vertebrate postsynaptic neurons.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	17204496
Pubmed	Activation of Alpha 7 Cholinergic Nicotinic Receptors Reduce Blood-Brain Barrier Permeability following Experimental Traumatic Brain Injury.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	26937017
Pubmed	α7 nicotinic receptors play a role in regulation of cardiac hemodynamics.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	37017608
Pubmed	Impaired hippocampal theta oscillations in the mice null alpha7 nicotinic acetylcholine receptors.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	23795917
Pubmed	Diminished α7 nicotinic acetylcholine receptor (α7nAChR) rescues amyloid-β induced atrial remodeling by oxi-CaMKII/MAPK/AP-1 axis-mediated mitochondrial oxidative stress.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	36603528
Pubmed	Endogenous signaling through alpha7-containing nicotinic receptors promotes maturation and integration of adult-born neurons in the hippocampus.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	20592195
Pubmed	Activation of α7nAChR Promotes Diabetic Wound Healing by Suppressing AGE-Induced TNF-α Production.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	26650489
Pubmed	Increased sensitivity to nicotine-induced seizures in mice expressing the L250T alpha 7 nicotinic acetylcholine receptor mutation.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	11854451
Pubmed	Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	22848433
Pubmed	Nicotine prevents synaptic impairment induced by amyloid-β oligomers through α7-nicotinic acetylcholine receptor activation.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	23842742
Pubmed	Abeta(1-42) modulation of Akt phosphorylation via alpha7 nAChR and NMDA receptors.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	17292512
Pubmed	Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	16650968
Pubmed	Microglial cell response in α7 nicotinic acetylcholine receptor-deficient mice after systemic infection with Escherichia coli.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	35413868
Pubmed	Circulating brain microvascular endothelial cells (cBMECs) as potential biomarkers of the blood-brain barrier disorders caused by microbial and non-microbial factors.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	23637989
Pubmed	Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7).	CHRFAM7A CHRNA7	2.73e-06	2	58	2	9782083
Pubmed	Long-term improvements in sensory inhibition with gestational choline supplementation linked to α7 nicotinic receptors through studies in Chrna7 null mutation mice.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	24462939
Pubmed	Probing the putative α7 nAChR/NMDAR complex in human and murine cortex and hippocampus: Different degrees of complex formation in healthy and Alzheimer brain tissue.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	29261717
Pubmed	Altered hippocampal circuit function in C3H alpha7 null mutant heterozygous mice.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	18199426
Pubmed	Stroke-induced activation of the α7 nicotinic receptor increases Pseudomonas aeruginosa lung injury.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	22490926
Pubmed	Kynurenic acid blunts A1 astrocyte activation against neurodegeneration in HIV-associated neurocognitive disorders.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	36997969
Pubmed	A phenotype for the alpha 7 nicotinic acetylcholine receptor null mutant.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	15364017
Pubmed	Choline, an alpha7 nicotinic acetylcholine receptor agonist, alleviates hyperalgesia in a rat osteoarthritis model.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	23769729
Pubmed	Mice deficient in CHRNA7, a subunit of the nicotinic acetylcholine receptor, produce sperm with impaired motility.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	15944242
Pubmed	Dendritic spine alterations in the hippocampus and parietal cortex of alpha7 nicotinic acetylcholine receptor knockout mice.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	23270857
Pubmed	Neuronal nicotinic alpha7 receptors modulate inflammatory cytokine production in the skin following ultraviolet radiation.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	18077004
Pubmed	Smoking in adult attention-deficit/hyperactivity disorder: interaction between 15q13 nicotinic genes and Temperament Character Inventory scores.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	19462340
Pubmed	Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	16923147
Pubmed	NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha 7 subunit of a neuronal nicotinic acetylcholine receptor.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	11790782
Pubmed	A role of the subdiaphragmatic vagus nerve in depression-like phenotypes in mice after fecal microbiota transplantation from Chrna7 knock-out mice with depression-like phenotypes.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	33422641
Pubmed	Nicotinic ACh receptor α7 inhibits PDGF-induced migration of vascular smooth muscle cells by activating mitochondrial deacetylase sirtuin 3.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	30270436
Pubmed	Activation of α-7 Nicotinic Acetylcholine Receptor Attenuates Cardiac Inflammation Through NLRP3/Caspase-1/IL-18 Pathway.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	34988776
Pubmed	Genetic deletion of α7 nAChRs reduces hippocampal granule and pyramidal cell number in both sexes but impairs pattern separation in males only.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	37746145
Pubmed	A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	19631623
Pubmed	Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint.	USP9X USP9Y	2.73e-06	2	58	2	12925892
Pubmed	Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	15770102
Pubmed	Cortical synaptic NMDA receptor deficits in α7 nicotinic acetylcholine receptor gene deletion models: implications for neuropsychiatric diseases.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	24326163
Pubmed	Loss of α7 nicotinic acetylcholine receptors in GABAergic neurons causes sex-dependent decreases in radial glia-like cell quantity and impairments in cognitive and social behavior.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	33398432
Pubmed	Functional role of alpha7 nicotinic receptor in chronic neuropathic and inflammatory pain: studies in transgenic mice.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	23811428
Pubmed	beta-Amyloid activates presynaptic alpha7 nicotinic acetylcholine receptors reconstituted into a model nerve cell system: involvement of lipid rafts.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	20374280
Pubmed	Proteome profile of the cerebellum from α7 nicotinic acetylcholine receptor deficient mice.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	38185761
Pubmed	Alpha 7 subunit of nAChR regulates migration of human mesenchymal stem cells.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	20720594
Pubmed	α7 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	22624500
Pubmed	Involvement of acetylcholine-α7nAChR in the protective effects of arterial baroreflex against ischemic stroke.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	23106973
Pubmed	Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	33902624
Pubmed	Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	17019565
Pubmed	Dilinoleoylphosphatidylcholine ameliorates scopolamine-induced impairment of spatial learning and memory by targeting alpha7 nicotinic ACh receptors.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	19100751
Pubmed	Identification of an alternatively processed nicotinic receptor alpha7 subunit RNA in mouse brain.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	14499477
Pubmed	Multiple calcium channels and kinases mediate alpha7 nicotinic receptor neuroprotection in PC12 cells.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	15969741
Pubmed	Activation of the α7 Nicotinic Acetylcholine Receptor Prevents against Microglial-Induced Inflammation and Insulin Resistance in Hypothalamic Neuronal Cells.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	35883638
Pubmed	Inflammation-induced increase in nicotinic acetylcholine receptor current in cutaneous nociceptive DRG neurons from the adult rat.	CHRFAM7A CHRNA7	2.73e-06	2	58	2	25453771
GeneFamily	ATP binding cassette subfamily A	ABCA1 ABCA13 ABCA9	2.83e-06	14	37	3	805
GeneFamily	Ubiquitin specific peptidases	USP9X USP9Y	5.85e-03	56	37	2	366
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF449 HINFP ZSCAN32 ZNF483 ZFP28	1.48e-02	718	37	5	28
GeneFamily	WD repeat domain containing	NWD1 CFAP43 WDR44	1.63e-02	262	37	3	362
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 FAM120A DYNC2H1 USP9X G6PC2 TMEM215	2.06e-07	195	58	6	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 FAM120A DYNC2H1 USP9X G6PC2 TMEM215	2.06e-07	195	58	6	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NWD1 DYNC2H1 ABCA13 SLIT1 CFAP43	2.75e-06	169	58	5	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DYNC2H1 SCN7A ADAMTS16 USP9Y CHRFAM7A	3.45e-06	177	58	5	c9e8149639551a4c8daa90fcb2b895fdcff2e2ba
ToppCell	COVID-19-kidney-PCT-S1\|kidney / Disease (COVID-19 only), tissue and cell type	SATB2 ABCA13 CHDH ALDH8A1 FGGY	4.16e-06	184	58	5	51ed1ebfdef45149541917c66cbacad87072e51f
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4\|TCGA-Pancreas / Sample_Type by Project: Shred V9	ABCA1 NALCN SCN7A TMEM215 ABCA9	4.16e-06	184	58	5	67164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SATB2 ABCA13 ADAMTS16 CFAP43	3.07e-05	137	58	4	0aa4e14b32da0cda677cc0ed6ae470f6ecd77bea
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HINFP PNPLA7 ABCA9 CHRNA7	6.49e-05	166	58	4	60060b03f2abfa3cc08107ab5a9f578e60e4ae16
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HINFP PNPLA7 ABCA9 CHRNA7	6.49e-05	166	58	4	ec9161d388db5a257b8d125c14f9dd911d5d5d4a
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HINFP PNPLA7 ABCA9 CHRNA7	6.49e-05	166	58	4	4586d6725403f879fc96f67be579022587ce1906
ToppCell	Ciliated_cells-B-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	NWD1 DYNC2H1 ABCA13 CFAP43	7.45e-05	172	58	4	187ae91148d293537afc77e10da2b64302322224
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NWD1 DYNC2H1 ABCA13 CFAP43	8.14e-05	176	58	4	dee780cfa85234a7cd7bf440b66b84cec959893e
ToppCell	IIH-CD8-antiviral_CD4\|IIH / Condition, Cell_class and T cell subcluster	ZNF483 PI4K2A ZSWIM6 SNX19	8.32e-05	177	58	4	fe73608c40701eca88b260aeb5c0640d7bee72ba
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHDH DNAH8 TLCD2 SH2D5	9.07e-05	181	58	4	d8d11ef83c4b8b6a6f5c8728e03059e45a8ad264
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN3_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHDH DNAH8 TLCD2 SH2D5	9.07e-05	181	58	4	e2d03115a87f45a7ddd3ade6b9ac3843639bd41a
ToppCell	COVID-19-kidney-PCT-S1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SATB2 ABCA13 CHDH ALDH8A1	9.47e-05	183	58	4	6878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SATB2 ABCA13 ADAMTS16 CFAP43	1.01e-04	186	58	4	5c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DYNC2H1 SCN7A ADAMTS16 ABCA9	1.03e-04	187	58	4	f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCell	COVID-19-kidney-Stressed_PCT\|kidney / Disease (COVID-19 only), tissue and cell type	CHDH ALDH8A1 PWWP3B FGGY	1.03e-04	187	58	4	acd305475f3609800af0d7bc68d83ef41228080b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DYNC2H1 SCN7A ADAMTS16 ABCA9	1.07e-04	189	58	4	e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCell	COPD-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	NWD1 DYNC2H1 ABCA13 CFAP43	1.07e-04	189	58	4	3e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCell	(12)_SLC16A7+\|World / shred by cell type by condition	CHDH ZNF483 CFAP43 ABCA9	1.12e-04	191	58	4	e427eeddd2e87c14376a37db0b43f120c90436bc
ToppCell	nucseq-Epithelial-Epithelial_Airway\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NWD1 DYNC2H1 ABCA13 CFAP43	1.12e-04	191	58	4	1c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 USP9X G6PC2 TMEM215	1.14e-04	192	58	4	5b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 USP9X G6PC2 TMEM215	1.14e-04	192	58	4	1304e69c92cef3bd8c82e3c035a7562f5440139a
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NWD1 DYNC2H1 ABCA13 CFAP43	1.16e-04	193	58	4	e1b76102f812c433195d1e8811fdd3293a7bc22e
ToppCell	Control-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	NWD1 DYNC2H1 ABCA13 CFAP43	1.16e-04	193	58	4	0e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NWD1 DYNC2H1 ABCA13 CFAP43	1.16e-04	193	58	4	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	ASK440-Epithelial-Ciliated\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	NWD1 DYNC2H1 ABCA13 CFAP43	1.16e-04	193	58	4	a0baa8be6f590b2031fede22be588715ae458e93
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 USP9X G6PC2 TMEM215	1.19e-04	194	58	4	92b39a935e8c577eb1123d706d168fa13cf3344c
ToppCell	NS-critical-LOC-Epithelial-Ciliated\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NWD1 DYNC2H1 ABCA13 CFAP43	1.21e-04	195	58	4	34e37cff4849696ca4ba5dd8fd2cf98fed8bc912
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NWD1 DYNC2H1 ABCA13 CFAP43	1.21e-04	195	58	4	9651ee03738226ee10e901f8b9ec6a417eb9c301
ToppCell	Tracheal-10x5prime-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ZNF449 NALCN CHTF18 ZNF654	1.21e-04	195	58	4	c96755d2eb98112b703b5dbee9c88730ace7dcbf
ToppCell	-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	SLIT1 SCN7A ADAMTS16 ABCA9	1.21e-04	195	58	4	e5b0afbea85575851cf9eb50a9ac42c67bbf3d7c
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NWD1 DYNC2H1 ABCA13 CFAP43	1.26e-04	197	58	4	87db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NWD1 DYNC2H1 ABCA13 CFAP43	1.26e-04	197	58	4	91637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell	Tracheal-10x3prime_v2-Stromal-Mesofibroblastic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CHTF18 SCN7A LRTM1 PI4K2A	1.26e-04	197	58	4	d7cef7881abd807a679432766ced609a6efd1067
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NWD1 DYNC2H1 ABCA13 CFAP43	1.26e-04	197	58	4	22c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell	Tracheal-10x3prime_v2-Stromal-Mesofibroblastic-Mesothelia\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CHTF18 SCN7A LRTM1 PI4K2A	1.26e-04	197	58	4	20a5958512bdb99daeb8f4d244df53e4f048f879
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NWD1 DYNC2H1 ABCA13 CFAP43	1.26e-04	197	58	4	3bbf068d2ad8196fbc85d3f311a7c54c9aece856
Drug	pilsicainide	SCN4A SCN7A CHRFAM7A CHRNA7	5.71e-06	46	58	4	CID000004820
Disease	cognitive disorder (implicated_via_orthology)	CHRFAM7A CHRNA7	5.09e-05	6	55	2	DOID:1561 (implicated_via_orthology)
Disease	rheumatoid arthritis (biomarker_via_orthology)	CHRFAM7A CHRNA7	5.09e-05	6	55	2	DOID:7148 (biomarker_via_orthology)
Disease	leptin measurement, sex interaction measurement	SLIT1 ABCA9	1.52e-04	10	55	2	EFO_0005000, EFO_0008343
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN4A SCN7A	1.52e-04	10	55	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN4A SCN7A	1.52e-04	10	55	2	DOID:0080422 (implicated_via_orthology)
Disease	nicotine dependence (implicated_via_orthology)	CHRFAM7A CHRNA7	2.22e-04	12	55	2	DOID:0050742 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN4A SCN7A	2.22e-04	12	55	2	DOID:0060170 (implicated_via_orthology)
Disease	Colorectal Carcinoma	SATB2 ABCA1 ABCA13 DNAH8 ABCA9 HPS3 GABRA6	3.15e-04	702	55	7	C0009402
Disease	Schizophrenia	ABCA1 VRK2 ABCA13 ATM CHRFAM7A CHRNA7 GABRA6	1.22e-03	883	55	7	C0036341
Disease	functional brain measurement, language measurement	VRK2 TBC1D5	1.25e-03	28	55	2	EFO_0007797, EFO_0007849
Disease	diastolic blood pressure, systolic blood pressure	LRIG3 CRIM1 DYNC2H1 SNX19 FGGY GABRA6	1.51e-03	670	55	6	EFO_0006335, EFO_0006336
Disease	Mental Retardation, X-Linked 1	CLCN4 USP9X	1.63e-03	32	55	2	C2931498
Disease	Colorectal Neoplasms	SATB2 ABCA1 ABCA13 ABCA9	1.78e-03	277	55	4	C0009404

Protein segments in the cluster

Peptide	Gene	Start	Entry
NRCLLKWLKLWDLVV	CHTF18	301	Q8WVB6
NILKWELELKRWCPG	EP400	1151	Q96L91
KKLQSGLVWTNCWLI	ALDH8A1	436	Q9H2A2
LALWNWESSIILCKK	CFAP43	136	Q8NDM7
QTWALLCKNCLKKWR	ABCA9	11	Q8IUA7
MACWPQLRLLLWKNL	ABCA1	1	O95477
CQFKALLWKNWLCRL	ABCA13	6	Q86UQ4
LLWKNWLCRLRNPVL	ABCA13	11	Q86UQ4
RDKCPLWQKWSELLV	CLCN4	126	P51793
LPLWQDCHELWSKKR	CDK13	1011	Q14004
RCHKPKKLQWLVSAW	ADAMTS16	1046	Q8TE57
KMPKWTRVILLNWCA	CHRNA7	326	P36544
QKPLRKVCIGLEWLW	CHDH	356	Q8NE62
LLCLWDLQARKWKFE	NWD1	1411	Q149M9
DCKLVQPLWKSVWRF	nan	1146	O00370
LWKCNCHLLGLKLWL	LRTM1	181	Q9HBL6
LLCDCQLKWLPQWVA	LRIG3	446	Q6UXM1
QVLRSWPWCNKELKT	CCDC28A	76	Q8IWP9
WRPILQAWLKKRTAQ	DNAH8	2271	Q96JB1
PWLCIILWLENALGK	GABRA6	6	Q16445
EWTCPNLKRLWLGKA	FAM120A	666	Q9NZB2
TTWILWRLLRKLQKC	MROH8	451	Q9H579
IQCWWRQVLEKLLAK	IQCF5	41	A8MTL0
KMPKWTRVILLNWCA	CHRFAM7A	236	Q494W8
LLWKRWNPLATKVKV	PNPLA7	1126	Q6ZV29
HLNPKWTKWLQKLCC	PI4K2A	161	Q9BTU6
WSNELSPVLNLWKKL	DYNC2H1	4036	Q8NCM8
QKSDLLKLWNKIWCI	ATM	476	Q13315
TKLLDLKEPTWKQWR	BFAR	316	Q9NZS9
LWLKENLREICWDKA	FGGY	151	Q96C11
REWTCPNLKKLWLGK	FAM120C	716	Q9NX05
NQKKQWIPLLCWYRT	CRIM1	961	Q9NZV1
DLLWSVPIAKKWCAN	G6PC2	231	Q9NQR9
NIKWLEKNLPTLRTW	ERAP2	941	Q6P179
KVPRKENLWLQCEWG	HINFP	6	Q9BQA5
WLCAPQAKQIWKCLA	USP9X	671	Q93008
LIWNCCAPWLKFKNI	SCN4A	556	P35499
NRTLWWKKLLPELCQ	HPS3	931	Q969F9
VLCNWKDQLWPAKVL	PWWP3B	6	Q5H9M0
WLVQQQLWALKDCPR	SH2D5	46	Q6ZV89
NKSQGWLCELLRWKE	SATB2	511	Q9UPW6
VLKWIRENIPEWKNC	PRPS1L1	151	P21108
AWCPDLKAVWKIKEL	ZFP28	171	Q8NHY6
SKLWELCCQWLRPKT	ZSCAN32	56	Q9NX65
LLWNQTLGKTWDLLC	TLCD2	96	A6NGC4
CTKWPENELLWVRKL	TMEM215	66	Q68D42
WPRLTKERAKLNWLS	PTGES3	86	Q15185
IPDKRLWWLKLTALA	VPS16	721	Q9H269
KLRLWNIPDKKVALW	WDR44	671	Q5JSH3
CIWELIFIWSKLQLK	ZNF654	296	Q8IZM8
LWLCAPQAKQIWKCL	USP9Y	671	O00507
DLLLLLLTEQWKWLC	SNX19	826	Q92543
LKQLKKWNSVDVCPW	ZSWIM6	466	Q9HCJ5
PRKALSQLWELCNQW	ZNF483	66	Q8TF39
TFLIWNCSPCWLKLK	SCN7A	481	Q01118
WKLFLCVLPQDKSQW	TBC1D5	91	Q92609
NCQLAWLGGWLRKRK	SLIT1	676	O75093
LRWLCGKLPWEQNLK	VRK2	241	Q86Y07
LWELCCQWLKPKMRS	ZNF449	51	Q6P9G9
LWINKPWVHSLLRIC	NALCN	31	Q8IZF0