Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ribose phosphate diphosphokinase activity	PRPSAP1 PRPSAP2	3.15e-05	5	36	2	GO:0004749
GeneOntologyMolecularFunction	diphosphotransferase activity	PRPSAP1 PRPSAP2	4.72e-05	6	36	2	GO:0016778
GeneOntologyBiologicalProcess	5-phosphoribose 1-diphosphate biosynthetic process	PRPSAP1 PRPSAP2	4.18e-05	6	35	2	GO:0006015
GeneOntologyBiologicalProcess	5-phosphoribose 1-diphosphate metabolic process	PRPSAP1 PRPSAP2	4.18e-05	6	35	2	GO:0046391
GeneOntologyCellularComponent	ribose phosphate diphosphokinase complex	PRPSAP1 PRPSAP2	2.71e-05	5	35	2	GO:0002189
Domain	Rib-P_diPkinase	PRPSAP1 PRPSAP2	3.21e-05	5	34	2	IPR005946
Domain	Pribosyl_synth	PRPSAP1 PRPSAP2	3.21e-05	5	34	2	PF14572
Domain	Pribosyltran_N	PRPSAP1 PRPSAP2	3.21e-05	5	34	2	IPR029099
Domain	Pribosyltran_N	PRPSAP1 PRPSAP2	3.21e-05	5	34	2	PF13793
Domain	Pribosyltran	PRPSAP1 PRPSAP2	1.75e-04	11	34	2	PF00156
Domain	-	PRPSAP1 PRPSAP2	2.10e-04	12	34	2	3.40.50.2020
Domain	PRTase-like	PRPSAP1 PRPSAP2	2.10e-04	12	34	2	IPR029057
Domain	PRibTrfase_dom	PRPSAP1 PRPSAP2	2.10e-04	12	34	2	IPR000836
Domain	DH_1	ARHGEF39 SOS2	5.86e-03	63	34	2	PS00741
Domain	RhoGEF	ARHGEF39 SOS2	6.80e-03	68	34	2	SM00325
Domain	DH_2	ARHGEF39 SOS2	7.19e-03	70	34	2	PS50010
Domain	RhoGEF	ARHGEF39 SOS2	7.19e-03	70	34	2	PF00621
Domain	DH-domain	ARHGEF39 SOS2	7.39e-03	71	34	2	IPR000219
Domain	-	ARHGEF39 SOS2	7.39e-03	71	34	2	1.20.900.10
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	CAPZB BEND3 DLG1 DSC1 AP2B1 BLOC1S2 DHX38 NOL6	8.67e-06	1005	37	8	19615732
Pubmed	Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.	DLG1 AP2B1	2.30e-05	7	37	2	23676497
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	CAPZB DNAJC9 DLG1 DSC1 AP2B1 KIAA1217 DHX38 NOL6	4.32e-05	1257	37	8	36526897
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	XRRA1 KIAA1217 DPEP3 DHX38 NOL6	7.95e-05	420	37	5	28065597
Pubmed	HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation.	DLG1 AP2B1	1.31e-04	16	37	2	21762802
Pubmed	A genome-wide association study of brain lesion distribution in multiple sclerosis.	DSC1 TLL1	1.31e-04	16	37	2	23412934
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DLG1 LATS2 PTPRE STEAP2 KIAA1217 TLL1 DNAH1 SOS2	1.41e-04	1489	37	8	28611215
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	DNAJC9 GOLIM4 DLG1 PARN PTCD1 KIAA2013 DHX38 NOL6	1.46e-04	1497	37	8	31527615
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	DSC1 AP2B1 MAP4K5 SOS2	1.81e-04	266	37	4	19380743
Pubmed	A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.	CAPZB AP2B1 KIAA1217	2.72e-04	118	37	3	30979931
Pubmed	Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years.	MAP4K5 SOS2	2.99e-04	24	37	2	24347629
Pubmed	Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway.	DLG1 LATS2	3.52e-04	26	37	2	28720576
Pubmed	Penetrance of craniofacial anomalies in mouse models of Smith-Magenis syndrome is modified by genomic sequence surrounding Rai1: not all null alleles are alike.	PRPSAP2 ULK2	3.80e-04	27	37	2	17273973
Pubmed	RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity.	CAPZB XPO4 NOL6	5.07e-04	146	37	3	21589869
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	CAPZB BEND3 DSC1 DHX38	5.52e-04	357	37	4	37059091
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DLG1 PARN TLL1 DHX38 NOL6	5.97e-04	650	37	5	38777146
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	BEND3 PARN AP2B1 DHX38 NOL6	6.09e-04	653	37	5	22586326
Pubmed	Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.	CAPZB DLG1 DHX38	6.15e-04	156	37	3	29961565
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	CAPZB DNAJC9 PRPSAP1 PRPSAP2 GOLIM4 AP2B1 DHX38	6.41e-04	1415	37	7	28515276
Pubmed	140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry.	CAPZB PTPRE AP2B1	6.99e-04	163	37	3	16512683
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	CAPZB BEND3 DLG1 LATS2 AP2B1 KIAA2013 NOL6	7.17e-04	1442	37	7	35575683
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	CAPZB DNAJC9 PARN AP2B1	7.97e-04	394	37	4	27248496
Pubmed	Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.	CAPZB PRPSAP2 DLG1 AP2B1	8.51e-04	401	37	4	25852190
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	DNAJC9 PRPSAP1 PRPSAP2 DHX38 NOL6	8.54e-04	704	37	5	29955894
Pubmed	CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.	CAPZB MGAM AP2B1	9.61e-04	182	37	3	31067453
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	XPO4 AP2B1 SOS2	9.76e-04	183	37	3	23956138
Pubmed	A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.	AP2B1 NOL6	1.01e-03	44	37	2	26471122
Cytoband	9p13.3	ARHGEF39 NOL6	1.69e-03	75	37	2	9p13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr9p13	ARHGEF39 NOL6	8.72e-03	174	37	2	chr9p13
Cytoband	Ensembl 112 genes in cytogenetic band chr16q22	DPEP3 DHX38	9.60e-03	183	37	2	chr16q22
Computational	Neighborhood of UBE2A	CAPZB PRPSAP1 PARN	2.03e-04	50	25	3	MORF_UBE2A
Disease	Arts syndrome (implicated_via_orthology)	PRPSAP1 PRPSAP2	1.53e-06	2	37	2	DOID:0050647 (implicated_via_orthology)
Disease	X-linked nonsyndromic deafness (implicated_via_orthology)	PRPSAP1 PRPSAP2	1.53e-06	2	37	2	DOID:0050566 (implicated_via_orthology)
Disease	Charcot-Marie-Tooth disease X-linked recessive 5 (implicated_via_orthology)	PRPSAP1 PRPSAP2	4.59e-06	3	37	2	DOID:0110210 (implicated_via_orthology)
Disease	benign neoplasm (implicated_via_orthology)	DLG1 LATS2	4.26e-05	8	37	2	DOID:0060072 (implicated_via_orthology)
Disease	urate measurement	PRPSAP1 TSKS CCDC26 MAP4K5 DHX38 DNAH1 SOS2	1.07e-04	895	37	7	EFO_0004531
Disease	lysophosphatidylcholine 14:0 measurement	ACOD1 MAP4K5	1.59e-04	15	37	2	EFO_0010356
Disease	mean reticulocyte volume	ACOD1 BEND3 AP2B1 CCDC26 MAP4K5 KIAA1217	4.39e-04	799	37	6	EFO_0010701
Disease	neuroblastoma, cutaneous melanoma	XPO4 NOL6	5.67e-04	28	37	2	EFO_0000389, EFO_0000621
Disease	HOMA-IR	MAP4K5 KIAA1217	7.88e-04	33	37	2	EFO_0004501
Disease	lysophosphatidylcholine 20:3 measurement	PARN MAP4K5	1.16e-03	40	37	2	EFO_0010362
Disease	ovarian serous carcinoma	PRPSAP1 TLL1	1.53e-03	46	37	2	EFO_1001516
Disease	cystatin C measurement	ALMS1 MAP4K5 KIAA1217 DNAH1	1.57e-03	402	37	4	EFO_0004617
Disease	total lipids in lipoprotein particles measurement	MAP4K5 DHX38	1.66e-03	48	37	2	EFO_0022309
Disease	lysophosphatidylcholine measurement	MGAM MAP4K5	2.76e-03	62	37	2	EFO_0010224
Disease	carcinoma (implicated_via_orthology)	DLG1 LATS2	2.94e-03	64	37	2	DOID:305 (implicated_via_orthology)
Disease	very low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	PARN MAP4K5 DHX38	3.33e-03	239	37	3	EFO_0008317, EFO_0020945
Disease	hemoglobin A1 measurement	MGAM STEAP2 MAP4K5 SOS2	3.97e-03	520	37	4	EFO_0007629

Protein segments in the cluster

Peptide	Gene	Start	Entry
LQPYLDQINVIEEQV	BLOC1S2	101	Q6QNY1
PEVQYVALRNINLIV	AP2B1	296	P63010
VNQQEVNYTRPVIIL	DLG1	706	Q12959
IQRSKRIYEQLPEVQ	ALMS1	4116	Q8TCU4
ELSQVLTQRQIYIQP	CAPZB	261	P47756
LPLQRLQQYENLVVA	ARHGEF39	151	Q8N4T4
IPYLNQEEERQLREQ	PARN	131	O95453
QELDPQRLQIIRNYT	BEND3	441	Q5T5X7
PQARQEEQVRVVRQF	PTPRE	576	P23469
YLDPRNEQIVRVIKQ	LATS2	141	Q9NRM7
VVERNRAAQLPYDVQ	MGAM	396	O43451
RVAYQREPQILKEVQ	NOL6	796	Q9H6R4
PYEEQLEQQRLAVQQ	GOLIM4	406	O00461
RTQNVPINKYQRLVV	CCDC26	51	Q8TAB7
QEVIRYNRLLQVITQ	DNAH1	4026	Q9P2D7
VLRLENYERQQQEVA	HAP1	371	P54257
VQYTEEPRIRNIIQQ	DNAJC9	151	Q8WXX5
PLNYEVNRQVILQVG	DSC1	421	Q08554
IKRIVLRIPNVQYVN	ACOD1	306	A6NK06
IQEEIPNYRNAVIVA	PRPSAP1	161	Q14558
VYQEPNRETRVQIQE	PRPSAP2	51	O60256
PQVLRQRYKNVLQDV	DPEP3	101	Q9H4B8
ILRRNPQQDYELVQR	MAP4K5	11	Q9Y4K4
RKEYVQPVQLRILNV	SOS2	676	Q07890
VTIIRENIQPGQEYN	TLL1	261	O43897
QRQRVLVEQERQKYL	KIAA1217	701	Q5T5P2
QQVIELARQLNFIPI	STEAP2	176	Q8NFT2
PVVQRQLEAVQERYL	IQANK1	491	A8MXQ7
VLQRPNLQKYVREQI	XPO4	101	Q9C0E2
SENLNYPVLVVVRQQ	SIDT1	86	Q9NXL6
APQIQYRRLLVQILQ	NMB	106	P08949
LEQRQYLPIFAVQQE	DHX38	526	Q92620
YLQQQLQDETPRRQE	TSKS	226	Q9UJT2
IPVPTQIRNYQRIEQ	ULK2	401	Q8IYT8
NRVPVNEVVIRQLEF	PTCD1	616	O75127
DENRIIRIPYLQQVQ	XRRA1	261	Q6P2D8
VYLQRIQLNNPTERV	KIAA2013	201	Q8IYS2