Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K4 monomethyltransferase activity	KMT2C KMT2D KMT2A	3.42e-06	8	80	3	GO:0140945
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	KMT2C KMT2D KMT2A	7.28e-06	10	80	3	GO:0140999
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	KMT2C KMT2D KMT2A KMT2E	2.87e-05	44	80	4	GO:0140938
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	KMT2C KMT2D KMT2A	6.72e-05	20	80	3	GO:0042800
GeneOntologyMolecularFunction	histone methyltransferase activity	KMT2C KMT2D KMT2A KMT2E	1.89e-04	71	80	4	GO:0042054
GeneOntologyMolecularFunction	histone modifying activity	KMT2C KMT2D KMT2A TAF1 KMT2E JMJD1C	3.16e-04	229	80	6	GO:0140993
GeneOntologyMolecularFunction	protein methyltransferase activity	KMT2C KMT2D KMT2A KMT2E	7.82e-04	103	80	4	GO:0008276
GeneOntologyMolecularFunction	minor groove of adenine-thymine-rich DNA binding	KMT2A POU3F4	8.52e-04	11	80	2	GO:0003680
GeneOntologyBiologicalProcess	protein-DNA complex organization	KMT2C RBM15 KMT2D CAND1 SMARCAL1 HIPK2 KMT2A DAPK3 ZDBF2 TAF1 KMT2E NIPBL JMJD1C EMSY	2.71e-05	999	80	14	GO:0071824
GeneOntologyBiologicalProcess	chromatin organization	KMT2C RBM15 KMT2D SMARCAL1 HIPK2 KMT2A DAPK3 ZDBF2 TAF1 KMT2E NIPBL JMJD1C EMSY	3.81e-05	896	80	13	GO:0006325
GeneOntologyCellularComponent	methyltransferase complex	KMT2C RBM15 KMT2D KMT2A TAF1	5.92e-05	108	80	5	GO:0034708
GeneOntologyCellularComponent	histone methyltransferase complex	KMT2C KMT2D KMT2A TAF1	1.97e-04	75	80	4	GO:0035097
Domain	FYrich_C	KMT2C KMT2D KMT2A	7.81e-07	5	81	3	IPR003889
Domain	FYrich_N	KMT2C KMT2D KMT2A	7.81e-07	5	81	3	IPR003888
Domain	FYRC	KMT2C KMT2D KMT2A	7.81e-07	5	81	3	SM00542
Domain	FYRN	KMT2C KMT2D KMT2A	7.81e-07	5	81	3	SM00541
Domain	FYRN	KMT2C KMT2D KMT2A	7.81e-07	5	81	3	PF05964
Domain	FYRC	KMT2C KMT2D KMT2A	7.81e-07	5	81	3	PF05965
Domain	FYRC	KMT2C KMT2D KMT2A	7.81e-07	5	81	3	PS51543
Domain	FYRN	KMT2C KMT2D KMT2A	7.81e-07	5	81	3	PS51542
Domain	SET	KMT2C KMT2D KMT2A KMT2E	2.94e-05	41	81	4	PF00856
Domain	Post-SET_dom	KMT2C KMT2D KMT2A	4.23e-05	16	81	3	IPR003616
Domain	PostSET	KMT2C KMT2D KMT2A	4.23e-05	16	81	3	SM00508
Domain	POST_SET	KMT2C KMT2D KMT2A	4.23e-05	16	81	3	PS50868
Domain	SET	KMT2C KMT2D KMT2A KMT2E	4.66e-05	46	81	4	SM00317
Domain	SET_dom	KMT2C KMT2D KMT2A KMT2E	6.50e-05	50	81	4	IPR001214
Domain	SET	KMT2C KMT2D KMT2A KMT2E	6.50e-05	50	81	4	PS50280
Domain	EPHD	KMT2C KMT2D KMT2A	1.14e-04	22	81	3	PS51805
Domain	PHD	KMT2C KMT2D KMT2A KMT2E	3.16e-04	75	81	4	PF00628
Domain	Znf_PHD-finger	KMT2C KMT2D KMT2A KMT2E	3.85e-04	79	81	4	IPR019787
Domain	Znf_FYVE_PHD	KMT2C KMT2D SYTL2 KMT2A KMT2E	4.47e-04	147	81	5	IPR011011
Domain	PHD	KMT2C KMT2D KMT2A KMT2E	6.06e-04	89	81	4	SM00249
Domain	Znf_PHD	KMT2C KMT2D KMT2A KMT2E	6.59e-04	91	81	4	IPR001965
Domain	ZF_PHD_2	KMT2C KMT2D KMT2A KMT2E	7.75e-04	95	81	4	PS50016
Domain	ZF_PHD_1	KMT2C KMT2D KMT2A KMT2E	8.06e-04	96	81	4	PS01359
Domain	SMAD_FHA_domain	STARD9 IRF3 AFDN	1.49e-03	52	81	3	IPR008984
Domain	AT_hook	KMT2C KMT2A	2.14e-03	16	81	2	PF02178
Domain	AT_hook	KMT2C KMT2A	6.08e-03	27	81	2	SM00384
Domain	AT_hook_DNA-bd_motif	KMT2C KMT2A	6.08e-03	27	81	2	IPR017956
Domain	FHA	STARD9 AFDN	6.53e-03	28	81	2	SM00240
Domain	RA	AFDN RASSF4	7.96e-03	31	81	2	SM00314
Domain	FHA	STARD9 AFDN	7.96e-03	31	81	2	PF00498
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	PLEKHG1 PTPN3 RBM15 STOX2 SORBS2 ALMS1 STARD9 KIAA1217 ANKRD26 KMT2A DAPK3 PLEKHA5 AFDN RICTOR SIK3 PEAK1 SKA3 CCSER1	1.69e-12	861	83	18	36931259
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	KMT2C KMT2D ALMS1 ANAPC1 TNRC6B KMT2A PLEKHA5 AFDN TAF1 PEAK1 SKA3 JMJD1C EMSY RPAP2	4.94e-11	549	83	14	38280479
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	TRAF7 ZSWIM8 RBM15 ALMS1 ANAPC1 ZGRF1 KIAA1217 HIPK2 ANKRD26 ZDBF2 FAM135A EMSY RPAP2	1.45e-09	588	83	13	38580884
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	KMT2C KMT2D KMT2A KMT2E	2.10e-09	8	83	4	23130995
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	PLEKHG1 RBM15 SORBS2 ALMS1 ANAPC1 ANKRD26 TNRC6B PLEKHA5 AFDN RICTOR RASSF4	9.61e-09	446	83	11	24255178
Pubmed	Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.	KMT2C KMT2D KMT2A	1.31e-08	3	83	3	23932714
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	STOX2 ALMS1 KIAA1217 ANKRD26 TNRC6B PLEKHA5 PEAK1 FAM135A JMJD1C	1.42e-08	263	83	9	34702444
Pubmed	A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.	KMT2C KMT2D KMT2A	5.23e-08	4	83	3	23129768
Pubmed	The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.	KMT2C KMT2D KMT2A	5.23e-08	4	83	3	24081332
Pubmed	Impact of WIN site inhibitor on the WDR5 interactome.	KMT2C KMT2D KMT2A RICTOR TAF1	6.14e-08	43	83	5	33472061
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	KMT2D ALMS1 ANAPC1 ZGRF1 TNRC6B PLEKHA5 ZDBF2 TAF1 SKA3 JMJD1C	6.29e-08	418	83	10	34709266
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KMT2C KMT2D KMT2A KMT2E	1.75e-07	21	83	4	27626377
Pubmed	Structural basis for activity regulation of MLL family methyltransferases.	KMT2C KMT2D KMT2A KMT2E	2.13e-07	22	83	4	26886794
Pubmed	New nomenclature for chromatin-modifying enzymes.	KMT2C KMT2D KMT2A TAF1 KMT2E	2.60e-07	57	83	5	18022353
Pubmed	Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers.	KMT2C KMT2D KMT2A	4.56e-07	7	83	3	36598580
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	STOX2 SORBS2 CAND1 ANAPC1 KIAA1217 TNRC6B DAPK3 PLEKHA5 AFDN SIK3 SPATS2 NIPBL EMSY	4.58e-07	963	83	13	28671696
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	KMT2C KMT2D KMT2A	7.28e-07	8	83	3	22266653
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	KMT2C KMT2D KMT2A	1.09e-06	9	83	3	22665483
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SH3TC2 ALMS1 SYTL2 ANKRD26 RICTOR PEAK1 FAM135A JMJD1C CCSER1	2.79e-06	493	83	9	15368895
Pubmed	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.	KMT2C KMT2D KMT2A	2.84e-06	12	83	3	27563068
Pubmed	Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.	KMT2C KMT2D	5.63e-06	2	83	2	28483418
Pubmed	The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape.	KMT2C KMT2D	5.63e-06	2	83	2	34156443
Pubmed	KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies.	KMT2C KMT2D	5.63e-06	2	83	2	31924266
Pubmed	Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma.	KMT2C KMT2D	5.63e-06	2	83	2	27280393
Pubmed	Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.	KMT2C KMT2D	5.63e-06	2	83	2	36869380
Pubmed	Set1 and MLL1/2 Target Distinct Sets of Functionally Different Genomic Loci In Vivo.	KMT2D KMT2A	5.63e-06	2	83	2	26711341
Pubmed	Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.	KMT2C KMT2D	5.63e-06	2	83	2	28967912
Pubmed	MLL-AF6 fusion oncogene sequesters AF6 into the nucleus to trigger RAS activation in myeloid leukemia.	KMT2A AFDN	5.63e-06	2	83	2	24695851
Pubmed	Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant.	KMT2D KMT2A	5.63e-06	2	83	2	24423662
Pubmed	Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice.	KMT2C KMT2D	5.63e-06	2	83	2	25346535
Pubmed	Altered expression of MLL methyltransferase family genes in breast cancer.	KMT2D KMT2E	5.63e-06	2	83	2	23754336
Pubmed	Association of KMT2C/D loss-of-function variants with response to immune checkpoint blockades in colorectal cancer.	KMT2C KMT2D	5.63e-06	2	83	2	36601880
Pubmed	Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.	KMT2D KMT2A TAF1	5.84e-06	15	83	3	14992727
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	KMT2C KMT2A KMT2E JMJD1C	5.89e-06	49	83	4	34368113
Pubmed	The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus.	PLEKHG1 KMT2C KMT2D	1.45e-05	20	83	3	33431871
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	KMT2C RBM15 GET4 CAND1 ANAPC1 SMARCAL1 KMT2A RICTOR ZDBF2 MUC12 SKA3 NIPBL EMSY	1.51e-05	1327	83	13	32694731
Pubmed	Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l.	KMT2A AFDN	1.69e-05	3	83	2	23361907
Pubmed	Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment.	KMT2D KMT2A	1.69e-05	3	83	2	26902498
Pubmed	MLL histone methylases regulate expression of HDLR-SR-B1 in presence of estrogen and control plasma cholesterol in vivo.	KMT2D KMT2A	1.69e-05	3	83	2	23192982
Pubmed	Mutations of PTCH1, MLL2, and MLL3 are not frequent events in hepatoblastoma.	KMT2C KMT2D	1.69e-05	3	83	2	22183980
Pubmed	The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis.	KMT2A AFDN	1.69e-05	3	83	2	16239140
Pubmed	Distinct pathways affected by menin versus MLL1/MLL2 in MLL-rearranged acute myeloid leukemia.	KMT2D KMT2A	1.69e-05	3	83	2	30315824
Pubmed	HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment.	KMT2C KMT2D	1.69e-05	3	83	2	21683083
Pubmed	Interaction network of human early embryonic transcription factors.	KMT2C KMT2D ALMS1 KMT2A TAF1 NIPBL EMSY	2.16e-05	351	83	7	38297188
Pubmed	Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation.	KMT2C KMT2D	3.37e-05	4	83	2	19221051
Pubmed	Cancer gene mutation frequencies for the U.S. population.	KMT2C KMT2D	3.37e-05	4	83	2	34645806
Pubmed	Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions.	KMT2D KMT2A	3.37e-05	4	83	2	22863532
Pubmed	MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.	KMT2C KMT2D	3.37e-05	4	83	2	28398509
Pubmed	De novo insertions and deletions of predominantly paternal origin are associated with autism spectrum disorder.	TNRC6B KMT2E	3.37e-05	4	83	2	25284784
Pubmed	KDM5A noncanonically binds antagonists MLL1/2 to mediate gene regulation and promotes epithelial to mesenchymal transition.	KMT2D KMT2A	3.37e-05	4	83	2	37722486
Pubmed	Viral induction of Zac1b through TLR3- and IRF3-dependent pathways.	IRF3 PLAGL1	3.37e-05	4	83	2	20947170
Pubmed	Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II.	KMT2C KMT2A	3.37e-05	4	83	2	19703992
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	STOX2 STARD9 MAP10 FAM135A JMJD1C	3.40e-05	153	83	5	10718198
Pubmed	SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.	TRAF7 SORBS2 GET4 TNRC6B AFDN RICTOR LMBRD2	3.46e-05	378	83	7	34315543
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	KMT2D KMT2A TAF1 NIPBL JMJD1C EMSY	4.55e-05	268	83	6	33640491
Pubmed	Evolving Catalytic Properties of the MLL Family SET Domain.	KMT2D KMT2A	5.60e-05	5	83	2	26320581
Pubmed	Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.	KMT2C KMT2D	5.60e-05	5	83	2	31127101
Pubmed	[Application of reverse transcription-multiplex nested PCR to detect MLL rearrangement in AML-M4/M5].	KMT2A AFDN	5.60e-05	5	83	2	16086288
Pubmed	MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.	KMT2D KMT2A	5.60e-05	5	83	2	28609655
Pubmed	The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling.	RICTOR SIK3	5.60e-05	5	83	2	30232230
Pubmed	MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ.	KMT2C KMT2D	5.60e-05	5	83	2	32601106
Pubmed	nArgBP2, a novel neural member of ponsin/ArgBP2/vinexin family that interacts with synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP).	SORBS2 AFDN	5.60e-05	5	83	2	10521485
Pubmed	A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.	KMT2C KMT2D	5.60e-05	5	83	2	26744420
Pubmed	Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.	KMT2D KMT2A TAF1	5.61e-05	31	83	3	15960975
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	ALMS1 ANAPC1 SYTL2 TNRC6B PLEKHA5 ZDBF2 SKA3 JMJD1C RPAP2	6.40e-05	733	83	9	34672954
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	KMT2D ALMS1 TNRC6B ANKRD12 JMJD1C	8.16e-05	184	83	5	32908313
Pubmed	Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs.	KMT2D KMT2A	8.39e-05	6	83	2	24176642
Pubmed	GRWD1-WDR5-MLL2 Epigenetic Complex Mediates H3K4me3 Mark and Is Essential for Kaposi's Sarcoma-Associated Herpesvirus-Induced Cellular Transformation.	KMT2D KMT2A	8.39e-05	6	83	2	34933446
Pubmed	MLL associates specifically with a subset of transcriptionally active target genes.	KMT2D KMT2A	8.39e-05	6	83	2	16199523
Pubmed	Common variation near ROBO2 is associated with expressive vocabulary in infancy.	CAND1 DAPK3	8.39e-05	6	83	2	25226531
Pubmed	Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.	KMT2C KMT2D	8.39e-05	6	83	2	17021013
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	RBM15 KMT2D SORBS2 ANAPC1 KMT2A AFDN RICTOR NIPBL EMSY	9.67e-05	774	83	9	15302935
Pubmed	Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.	KMT2C KMT2D	1.17e-04	7	83	2	30604749
Pubmed	Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-kappaB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes.	KMT2D KMT2A	1.17e-04	7	83	2	19219072
Pubmed	Unique Role of the WD-40 Repeat Protein 5 (WDR5) Subunit within the Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Complex.	KMT2C KMT2A	1.17e-04	7	83	2	26324722
Pubmed	PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease.	GPLD1 JMJD1C	1.17e-04	7	83	2	20648472
Pubmed	ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.	KMT2C KMT2D	1.17e-04	7	83	2	19556342
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	KMT2D SMARCAL1 SYPL1 ZDBF2 SIK3 WDR17 TRIM64C NIPBL	1.45e-04	638	83	8	31182584
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	ALMS1 TNRC6B PLEKHA5 ZDBF2 PEAK1	1.48e-04	209	83	5	36779422
Pubmed	Four enzymes cooperate to displace histone H1 during the first minute of hormonal gene activation.	KMT2C KMT2D	1.56e-04	8	83	2	21447625
Pubmed	Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation.	VCAN ADAMTS20	1.56e-04	8	83	2	21041365
Pubmed	The mutational landscape of lethal castration-resistant prostate cancer.	KMT2D KMT2A	1.56e-04	8	83	2	22722839
Pubmed	H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development.	KMT2C KMT2D	1.56e-04	8	83	2	30335158
Pubmed	The secreted metalloprotease ADAMTS20 is required for melanoblast survival.	VCAN ADAMTS20	1.56e-04	8	83	2	18454205
Pubmed	A human MAP kinase interactome.	KMT2C PTPN3 HIPK2 PLEKHA5 MUC12 TAF1 SIK3	1.66e-04	486	83	7	20936779
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	KMT2C FBXW8 KMT2D CAND1 ANAPC1 KMT2A RICTOR	1.85e-04	495	83	7	27705803
Pubmed	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.	KMT2C KMT2D KMT2A NIPBL	1.94e-04	119	83	4	23508102
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	PLEKHG1 ALMS1 KIAA1217 ANKRD26 TNRC6B AFDN SIK3 HSPA2 EMSY	2.00e-04	853	83	9	28718761
Pubmed	The SUMO-specific isopeptidase SENP3 regulates MLL1/MLL2 methyltransferase complexes and controls osteogenic differentiation.	KMT2D KMT2A	2.00e-04	9	83	2	24930734
Pubmed	WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development.	KMT2D KMT2A	2.00e-04	9	83	2	15960974
Pubmed	Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.	KMT2D KMT2A	2.00e-04	9	83	2	16951254
Pubmed	Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors.	KMT2D KMT2A	2.00e-04	9	83	2	26691508
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	KMT2C ALMS1 TNRC6B PLEKHA5 SIK3	2.09e-04	225	83	5	12168954
Pubmed	PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome.	ALMS1 TNRC6B SKA3	2.23e-04	49	83	3	31762063
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	RBM15 SORBS2 KIAA1217 PLEKHA5 NIPBL EMSY	2.28e-04	360	83	6	33111431
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	PCDHGC5 STARD9 ZGRF1 KIAA1217 ADAMTS20 HSPA2 EMSY	2.30e-04	513	83	7	25798074
Pubmed	Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.	RBM15 SORBS2 STARD9 KIAA1217 PEAK1 EMSY	2.31e-04	361	83	6	30344098
Pubmed	Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.	KMT2C KMT2D KMT2A	2.37e-04	50	83	3	37974198
Pubmed	A model for obesity and gigantism due to disruption of the Ankrd26 gene.	ANKRD26 SIM1	2.50e-04	10	83	2	18162531
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	ANKRD26 TNRC6B PLEKHA5 AFDN RICTOR PEAK1 FAM135A JMJD1C	2.92e-04	708	83	8	39231216
Interaction	YWHAH interactions	PLEKHG1 PTPN3 RBM15 STOX2 SORBS2 ALMS1 STARD9 KIAA1217 ANKRD26 KMT2A DAPK3 PLEKHA5 AFDN RICTOR SIK3 PEAK1 SKA3 CCSER1	1.91e-07	1102	79	18	int:YWHAH
Interaction	AFDN interactions	SORBS2 KIAA1217 ANKRD26 TNRC6B KMT2A PLEKHA5 AFDN RICTOR PEAK1 HSPA2	6.96e-07	333	79	10	int:AFDN
Interaction	WWTR1 interactions	KMT2D ALMS1 ANAPC1 TNRC6B KMT2A PLEKHA5 AFDN PEAK1 SKA3 JMJD1C EMSY	7.50e-07	422	79	11	int:WWTR1
Interaction	PHF21A interactions	KMT2D ALMS1 ANAPC1 ZGRF1 TNRC6B PLEKHA5 ZDBF2 TAF1 SKA3 JMJD1C	9.10e-07	343	79	10	int:PHF21A
Interaction	YWHAG interactions	PLEKHG1 PTPN3 RBM15 STOX2 SORBS2 ALMS1 STARD9 ANKRD26 KMT2A DAPK3 PLEKHA5 AFDN RICTOR SIK3 PEAK1 SKA3 CCSER1	5.33e-06	1248	79	17	int:YWHAG
Interaction	RNF43 interactions	STOX2 ALMS1 KIAA1217 ANKRD26 TNRC6B PLEKHA5 PEAK1 HSPA2 FAM135A JMJD1C	6.42e-06	427	79	10	int:RNF43
Interaction	MYB interactions	TRAF7 KMT2D HIPK2 KMT2A NIPBL EMSY	1.38e-05	133	79	6	int:MYB
Interaction	SFN interactions	PTPN3 STOX2 SORBS2 ALMS1 ANKRD26 KMT2A PLEKHA5 RICTOR SIK3 PEAK1 SKA3 CCSER1	1.52e-05	692	79	12	int:SFN
Interaction	LZTS2 interactions	PLEKHG1 PTPN3 RBM15 SORBS2 ALMS1 KIAA1217 HIPK2 TNRC6B PLEKHA5 AFDN	3.07e-05	512	79	10	int:LZTS2
Interaction	ZYX interactions	CAND1 ALMS1 KIAA1217 HIPK2 TNRC6B PLEKHA5 PEAK1 FAM135A	4.42e-05	329	79	8	int:ZYX
Interaction	YAP1 interactions	KMT2C KMT2D CAND1 ANAPC1 GLIS3 TNRC6B KMT2A IRF3 AFDN TAF1 SKA3 HSPA2 JMJD1C RPAP2	8.15e-05	1095	79	14	int:YAP1
Interaction	YWHAQ interactions	PTPN3 STOX2 FBXW8 SORBS2 STARD9 ANKRD26 KMT2A DAPK3 PLEKHA5 AFDN RICTOR SIK3 PEAK1 CCSER1	1.02e-04	1118	79	14	int:YWHAQ
Interaction	B4GALT2 interactions	ZSWIM8 ANAPC1 RICTOR TAF1 HSPA2	1.05e-04	119	79	5	int:B4GALT2
Interaction	IQCF2 interactions	GET4 TAF1 HSPA2	1.25e-04	25	79	3	int:IQCF2
Interaction	RCOR1 interactions	KMT2D ALMS1 ANAPC1 ZGRF1 TNRC6B PLEKHA5 ZDBF2 TAF1 JMJD1C	1.34e-04	494	79	9	int:RCOR1
Interaction	LATS2 interactions	PLEKHG1 RBM15 ALMS1 ANAPC1 TNRC6B PLEKHA5 AFDN	1.39e-04	289	79	7	int:LATS2
Interaction	FEV interactions	KMT2C KMT2D KMT2A TAF1 NIPBL EMSY	1.46e-04	203	79	6	int:FEV
Interaction	YWHAB interactions	PTPN3 STOX2 SORBS2 STARD9 ANKRD26 KMT2A DAPK3 PLEKHA5 AFDN RICTOR SIK3 PEAK1 CCSER1	1.47e-04	1014	79	13	int:YWHAB
Interaction	YWHAZ interactions	PTPN3 RBM15 STOX2 SORBS2 MAPKAPK2 STARD9 ANKRD26 KMT2A PLEKHA5 AFDN RICTOR SIK3 PEAK1 HSPA2 CCSER1	1.63e-04	1319	79	15	int:YWHAZ
Interaction	CEP128 interactions	PLEKHG1 ZSWIM8 ALMS1 ANKRD26 TNRC6B DAPK3 ZDBF2	1.65e-04	297	79	7	int:CEP128
Interaction	PFN1 interactions	CAND1 ALMS1 KIAA1217 ANKRD26 PLEKHA5 AFDN PEAK1 FAM135A RPAP2	1.67e-04	509	79	9	int:PFN1
Interaction	HERC2P9 interactions	GET4 RICTOR TAF1	2.18e-04	30	79	3	int:HERC2P9
Cytoband	Ensembl 112 genes in cytogenetic band chr7q22	TMEM130 SYPL1 MUC12 KMT2E	7.21e-04	219	84	4	chr7q22
Cytoband	5p13.2	LMBRD2 NIPBL	1.49e-03	31	84	2	5p13.2
Cytoband	10p12.1	PTCHD3 ANKRD26	1.58e-03	32	84	2	10p12.1
Cytoband	7p22.3	GET4 ELFN1	1.79e-03	34	84	2	7p22.3
Cytoband	4q35.1	STOX2 SORBS2	2.00e-03	36	84	2	4q35.1
Cytoband	Ensembl 112 genes in cytogenetic band chr5p13	RICTOR LMBRD2 NIPBL	2.16e-03	139	84	3	chr5p13
Cytoband	Ensembl 112 genes in cytogenetic band chr10p12	PTCHD3 KIAA1217 ANKRD26	2.21e-03	140	84	3	chr10p12
Cytoband	12q13.12	KMT2D SPATS2	2.23e-03	38	84	2	12q13.12
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2C KMT2D KMT2A KMT2E	3.08e-06	34	54	4	487
GeneFamily	PHD finger proteins	KMT2C KMT2D KMT2A KMT2E	1.50e-04	90	54	4	88
GeneFamily	Ataxins\|Trinucleotide repeat containing	KMT2D TNRC6B	2.51e-03	25	54	2	775
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_1000	GPLD1 CACNA1D STOX2 CAND1 TMTC4 ANAPC1 VCAN HIPK2 ADAMTS20 PLEKHA5 PLAGL1 FAM135A	4.08e-05	806	79	12	gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000
CoexpressionAtlas	kidney_P4_CapMesRenVes_Crym_top-relative-expression-ranked_200	PTPN3 SORBS2 VCAN GLIS3 HIPK2 SIM1	4.86e-05	175	79	6	gudmap_kidney_P4_CapMesRenVes_Crym_200
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500	STOX2 SORBS2 ALMS1 ANKRD26 POU3F4 ZDBF2 SIM1 NIPBL JHY	9.59e-05	498	79	9	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500
CoexpressionAtlas	kidney_P4_CapMesRenVes_Crym_top-relative-expression-ranked_500	PTPN3 SORBS2 GLDN KIAA1217 VCAN GLIS3 HIPK2 SIM1	1.16e-04	398	79	8	gudmap_kidney_P4_CapMesRenVes_Crym_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#2_top-relative-expression-ranked_500	STOX2 ANAPC1 VCAN HIPK2 TNRC6B PLEKHA5	1.29e-04	209	79	6	gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_500_k2
CoexpressionAtlas	DevelopingKidney_e15.5_cortic collect duct_emap-28132_top-relative-expression-ranked_1000	CACNA1D SORBS2 KIAA1217 GLIS3 HIPK2 ADAMTS20 PLEKHA5 SIM1 FAM135A SLC44A3 CCSER1	1.33e-04	774	79	11	gudmap_developingKidney_e15.5_cortic collect duct_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#2_top-relative-expression-ranked_1000	TMTC4 ANAPC1 VCAN HIPK2 PLEKHA5 PLAGL1 FAM135A	1.62e-04	312	79	7	gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000_k2
CoexpressionAtlas	dev gonad_e11.5_M_GonadVasMes_Flk_top-relative-expression-ranked_500	GLDN KIAA1217 VCAN SYTL2 PLAGL1 ZDBF2 LRRC4C SPATS2	1.62e-04	418	79	8	gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_500
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	KMT2C TNRC6B KMT2A RICTOR ANKRD12 SIK3 NIPBL JMJD1C	2.66e-09	188	84	8	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	VCAN TNRC6B PLEKHA5 AFDN PLAGL1 RICTOR KMT2E NIPBL	3.14e-09	192	84	8	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	VCAN TNRC6B PLEKHA5 AFDN PLAGL1 RICTOR KMT2E NIPBL	3.27e-09	193	84	8	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	ILEUM-inflamed-(3)_MNP-(3)_moDC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	TMEM130 HIPK2 TNRC6B RICTOR LRRC4C KMT2E JMJD1C	6.62e-08	187	84	7	0099def970fbc828756fbf853eca2ce77b8cd342
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	SORBS2 GLIS3 TNRC6B PLEKHA5 SIK3 JMJD1C CCSER1	7.93e-08	192	84	7	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1D PTPN3 GLIS3 PLEKHA5 AFDN SLC44A3 CCSER1	8.21e-08	193	84	7	3866667dd221612589ae50f5c52f73a183a49ce6
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1D PTPN3 GLIS3 PLEKHA5 SIM1 SLC44A3 CCSER1	8.51e-08	194	84	7	5eaaa81f4b2535f983c424aaef00077089526a5c
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	HIPK2 ANKRD26 TNRC6B KMT2A RICTOR ANKRD12	1.07e-06	177	84	6	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PLEKHG1 STOX2 ADAMTS20 AFDN OSBP2 PEAK1	1.22e-06	181	84	6	e898ecb8d8f2eb2204225b7b0d665cadcd241139
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PLEKHG1 STOX2 ADAMTS20 AFDN OSBP2 PEAK1	1.43e-06	186	84	6	20340a5b5cc7f07386498a4ef937d6fbc9e347c4
ToppCell	Adult-Epithelial-club_cell-D231\|Adult / Lineage, Cell type, age group and donor	PLEKHG1 TMEM130 SORBS2 KIAA1217 GLIS3 CCSER1	1.48e-06	187	84	6	ee59d7d3de5879738ff0b9c3ea5e4847fb48cb86
ToppCell	COVID-19-kidney-CD-PC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PTPN3 SYTL2 GLIS3 SIM1 FYB2 CCSER1	1.52e-06	188	84	6	8f9996c3f3b27efaaae8960a66af77412de9c7ef
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	STOX2 SORBS2 KIAA1217 DAPK3 FYB2 CCSER1	1.57e-06	189	84	6	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	Adult-Epithelial-club_cell\|Adult / Lineage, Cell type, age group and donor	PLEKHG1 TMEM130 SORBS2 KIAA1217 GLIS3 CCSER1	1.62e-06	190	84	6	756bff697d30aec56c0ebfca94295f084a15bf37
ToppCell	COVID-19-kidney-CNT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PTPN3 SYTL2 GLIS3 SIM1 FYB2 CCSER1	1.72e-06	192	84	6	760c6b9628de9693034b00c5025c5c4df94bb2e8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1D PTPN3 GLIS3 PLEKHA5 SLC44A3 CCSER1	1.77e-06	193	84	6	82e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN3 GLIS3 PLEKHA5 AFDN SIM1 CCSER1	1.88e-06	195	84	6	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	KMT2C ELFN1 SYTL2 KMT2A ZDBF2 ANKRD12	2.00e-06	197	84	6	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_monocytic-monocyte\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SORBS2 KIAA1217 GLIS3 RASSF4 HSPA2 SLC44A3	2.00e-06	197	84	6	b2f4d7c301c0b24003374923b31d6d058e40b213
ToppCell	(09)_Interm._secr.>cil.-(2)_GFP_FOXI1\|(09)_Interm._secr.>cil. / shred by cell type by condition	GLIS3 HIPK2 ANKRD26 TNRC6B ANKRD12 NIPBL	2.12e-06	199	84	6	fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell	kidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	STOX2 SORBS2 VCAN KMT2A AFDN SLC44A3	2.12e-06	199	84	6	174f6013af6eafa577f84205a62927f2b367fda3
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	KMT2C KIAA1217 KMT2A AFDN FAM135A NIPBL	2.18e-06	200	84	6	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	Macroglial-Polydendrocytes-PDGFRA-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	CACNA1D SORBS2 KIAA1217 VCAN LRRC4C CCSER1	2.18e-06	200	84	6	f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCell	Macroglial-Polydendrocytes-PDGFRA--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	CACNA1D SORBS2 KIAA1217 VCAN LRRC4C CCSER1	2.18e-06	200	84	6	cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCell	Tracheal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PTPN3 STOX2 SORBS2 KIAA1217 SLC44A3 CCSER1	2.18e-06	200	84	6	d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCell	Macroglial-Polydendrocytes-PDGFRA\|Macroglial / cells hierarchy compared to all cells using T-Statistic	CACNA1D SORBS2 KIAA1217 VCAN LRRC4C CCSER1	2.18e-06	200	84	6	c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	KMT2C KMT2A ANKRD12 KMT2E NIPBL JMJD1C	2.18e-06	200	84	6	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	Macroglial-Polydendrocytes-PDGFRA---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	CACNA1D SORBS2 KIAA1217 VCAN LRRC4C CCSER1	2.18e-06	200	84	6	4fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCell	Macroglial-Polydendrocytes-PDGFRA----L1-6\|Macroglial / cells hierarchy compared to all cells using T-Statistic	CACNA1D SORBS2 KIAA1217 VCAN LRRC4C CCSER1	2.18e-06	200	84	6	310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCell	Macroglial-Polydendrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	CACNA1D SORBS2 KIAA1217 VCAN LRRC4C CCSER1	2.18e-06	200	84	6	961858738ce35db8760c8c2e136f8369bc444ccf
ToppCell	TCGA-Peripheral_Nervous_System-Primary_Tumor-Paraganglioma-Paraganglioma-3\|TCGA-Peripheral_Nervous_System / Sample_Type by Project: Shred V9	CACNA1D KMT2D PLEKHA5 AFDN WDR17	5.76e-06	135	84	5	ac20133d4a36f48338b45bffb13e842cb66f83ad
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-3\|TCGA-Brain / Sample_Type by Project: Shred V9	RBM15 VCAN ADAMTS20 RICTOR JMJD1C	9.31e-06	149	84	5	768877bade04ca0321593b8470b5011ad8270431
ToppCell	3'_v3-blood-Lymphocytic_T_CD4-Trm_Th1/Th17\|blood / Manually curated celltypes from each tissue	PLEKHG1 PLEKHA5 AFDN HSPA2 SLC44A3	1.06e-05	153	84	5	d09bc7322b59f613d66673359ee6af1aea99ce87
ToppCell	LPS-IL1RA+antiTNF\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1D STOX2 SORBS2 KIAA1217 TNRC6B	2.14e-05	177	84	5	b7fee75de7e96924af488a5baa2334711889ae7c
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PLEKHG1 STOX2 AFDN OSBP2 PEAK1	2.20e-05	178	84	5	ad3de3e03a401dac64431a541899445262246347
ToppCell	RV\|World / Chamber and Cluster_Paper	STOX2 SORBS2 TNRC6B FYB2 CCSER1	2.38e-05	181	84	5	bbe1e6e59d8889bd37d6e8303116cbdcafca7236
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	PTPN3 STOX2 KIAA1217 GLIS3 CCSER1	2.64e-05	185	84	5	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1D STOX2 SORBS2 PLEKHA5 RASSF4	2.71e-05	186	84	5	b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l20-23\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SYTL2 GLIS3 ADAMTS20 ZDBF2 WDR17	2.78e-05	187	84	5	69b47f00598d647e2a99427ebddf42c339428e47
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SH3TC2 GLDN VCAN HIPK2 HSPA2	2.85e-05	188	84	5	60242c29c7f16c94a84685d3bc4ed93a66e70152
ToppCell	COVID-19-Epithelial_cells\|COVID-19 / group, cell type (main and fine annotations)	PTPN3 STOX2 SORBS2 KIAA1217 CCSER1	2.85e-05	188	84	5	c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SYTL2 GLIS3 SPATS2 SIM1 CCSER1	2.85e-05	188	84	5	4154f4787483c7e076e87a187733a9f666742c3d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SYTL2 GLIS3 SIM1 FYB2 CCSER1	2.93e-05	189	84	5	8ff3c3232eff9de4b5c9b22ecb82bc509d773f58
ToppCell	COVID-19-lung-Secretory\|lung / Disease (COVID-19 only), tissue and cell type	PTPN3 KIAA1217 GLIS3 FYB2 CCSER1	2.93e-05	189	84	5	84d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCell	renal_medulla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	STOX2 KIAA1217 SIK3 SIM1 CCSER1	2.93e-05	189	84	5	830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|RV / Chamber and Cluster_Paper	STOX2 SORBS2 DAPK3 SIK3 CCSER1	3.00e-05	190	84	5	93c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SYTL2 GLIS3 SIM1 FYB2 CCSER1	3.00e-05	190	84	5	4836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_B-B_naive\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	PLEKHG1 EFCAB13 SYPL1 CD72 CCSER1	3.00e-05	190	84	5	e63945fa1dcd58bee129f1dd0c23b64a76241554
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_B-B_naive-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	PLEKHG1 EFCAB13 SYPL1 CD72 CCSER1	3.00e-05	190	84	5	fa65bc5a178ae0c80a9bd4b282e4539493128a64
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PTPN3 STOX2 KIAA1217 LRRC4C CCSER1	3.08e-05	191	84	5	34cc997e4e5c727495f321e6807a84aa124da486
ToppCell	Children_(3_yrs)-Epithelial-club_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PLEKHG1 TMEM130 SORBS2 KIAA1217 CCSER1	3.08e-05	191	84	5	23776c7302cead3881b39127398f3b3e0d27885e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GLIS3 SPATS2 SIM1 FYB2 CCSER1	3.08e-05	191	84	5	96b78b4e819ea6052334bfcbc7abbf35897df885
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	KMT2C KMT2A ANKRD12 SIK3 JMJD1C	3.16e-05	192	84	5	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PTPN3 STOX2 KIAA1217 LRRC4C CCSER1	3.16e-05	192	84	5	fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCell	Epithelial-club_cell\|World / Lineage, Cell type, age group and donor	PLEKHG1 TMEM130 KIAA1217 GLIS3 CCSER1	3.23e-05	193	84	5	2bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	VCAN SYTL2 GLIS3 DAPK3 SIK3	3.23e-05	193	84	5	cf3cbf79ccd34ddcf06ec6194a18a7afd7f91f39
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	STOX2 SYTL2 AFDN SIM1 CCSER1	3.32e-05	194	84	5	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN3 STOX2 PLEKHA5 AFDN FAM135A	3.32e-05	194	84	5	7002937e8903e037332a215d00fbc7c7843b33f2
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	SORBS2 KIAA1217 GLIS3 PLEKHA5 FYB2	3.40e-05	195	84	5	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	IPF-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	SORBS2 KIAA1217 GLIS3 PLEKHA5 FYB2	3.40e-05	195	84	5	21dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	SORBS2 KIAA1217 GLIS3 PLEKHA5 FYB2	3.40e-05	195	84	5	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN3 AFDN SIM1 FYB2 CCSER1	3.48e-05	196	84	5	c7136b1c83bcf907eec3b02b151fa061298b6672
ToppCell	IPF-Epithelial\|IPF / Disease state, Lineage and Cell class	SORBS2 KIAA1217 GLIS3 PLEKHA5 FYB2	3.48e-05	196	84	5	87d9881cfec461a5d89b688a83749b618c519485
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1D PTPN3 SYTL2 EFCAB13 CCSER1	3.57e-05	197	84	5	7e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	KMT2C RICTOR ANKRD12 KMT2E JMJD1C	3.57e-05	197	84	5	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	IPF-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	CACNA1D GLDN VCAN PLEKHA5 LRRC4C	3.57e-05	197	84	5	f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	KMT2C RICTOR ANKRD12 KMT2E JMJD1C	3.65e-05	198	84	5	44417089b62056269cac38d3134ff209c05b7007
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	STOX2 GLIS3 SIK3 PEAK1 CCSER1	3.65e-05	198	84	5	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	KMT2C RICTOR ANKRD12 KMT2E JMJD1C	3.65e-05	198	84	5	28ef3fc4c17dcb765537b75917f7db78baa522db
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Newborn-35\|World / Primary Cells by Cluster	SORBS2 VCAN KMT2A KMT2E CCSER1	3.65e-05	198	84	5	de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCell	Bronchial-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PTPN3 STOX2 SORBS2 KIAA1217 CCSER1	3.74e-05	199	84	5	5f7da3eab58ace6cddb3179a415cd839d5767958
ToppCell	NS-moderate-d_0-4-Epithelial\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PTPN3 KIAA1217 SYTL2 PLEKHA5 AFDN	3.83e-05	200	84	5	64462a18afca3c1a8548a857924b8166058bf958
ToppCell	NS-control-d_0-4-Epithelial\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PTPN3 SORBS2 KIAA1217 PLEKHA5 AFDN	3.83e-05	200	84	5	d014959891893b6d3854a471fba1dc50c6625a0a
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	STOX2 SORBS2 KIAA1217 SLC44A3 CCSER1	3.83e-05	200	84	5	0eb9ad8c0373bcc62029ec21c590ed03aaacd039
ToppCell	control-B_cell\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PLEKHG1 CACNA1D AFDN SLC44A3	1.01e-04	128	84	4	24abab941b4a2f89e13089d208d40ec02f0cad10
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma-3\|TCGA-Brain / Sample_Type by Project: Shred V9	VCAN ADAMTS20 RICTOR JMJD1C	1.24e-04	135	84	4	b128596653a5e3b64ed7f657bbfeda35438e2e48
ToppCell	ILEUM-non-inflamed-(3)_MNP-(3)_moDC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	HIPK2 ANKRD12 KMT2E JMJD1C	1.24e-04	135	84	4	b7a792a7c0c22d8b703509f134115f0e394d7de0
ToppCell	IIF-Lymphocyte-T_NK-dnT\|IIF / Disease, Lineage and Cell Type	PTPN3 SORBS2 TMTC4 JHY	1.68e-04	146	84	4	d0f361662db5f7be26104346e8431f7e30c5ce3a
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-matrix_-_immature_3\|E16.5-samps / Age Group, Lineage, Cell class and subclass	ZSWIM8 GLDN VCAN GLIS3	1.81e-04	149	84	4	651494e84be03dc7b061ebdfa91756a1c507b9b4
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-14\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GPLD1 RBM15 WDR17 CCSER1	1.86e-04	150	84	4	4bdcdce40f54580c7a4e1416b468e657ba8874fc
ToppCell	Cerebellum-Macroglia-ASTROCYTE\|Cerebellum / BrainAtlas - Mouse McCarroll V32	GPLD1 NAT1 POU3F4 TEKT4	1.91e-04	151	84	4	71841d2001200d1595c85c2b007ee20791a72927
ToppCell	Cerebellum-Macroglia-ASTROCYTE-Gja1\|Cerebellum / BrainAtlas - Mouse McCarroll V32	GPLD1 NAT1 POU3F4 TEKT4	1.91e-04	151	84	4	60aced0c1cc6b509b73308d03d58a3c44d712ef4
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN3 GLIS3 SPATS2 FYB2	2.01e-04	153	84	4	79c4f4ccdc8249c8461075c73491bc3b2d13344a
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	KMT2C RICTOR ANKRD12 JMJD1C	2.16e-04	156	84	4	1545169694f686d28648a68b552c2ae606599d66
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1D PTPN3 SIM1 CCSER1	2.16e-04	156	84	4	4d2679e7639758c49fc25a2deb9109b08f0a3e57
ToppCell	control-B_cell\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PLEKHG1 CACNA1D AFDN SLC44A3	2.22e-04	157	84	4	1269b55f2ef6a493f6116b131cc5cc7b8897d63e
ToppCell	mild_COVID-19_(asymptomatic)-B_cell\|World / disease group, cell group and cell class (v2)	CD72 DAPK3 DNAJB7 CCSER1	2.27e-04	158	84	4	afa8fa21c39c2192c1e23a4660011d63d58b733f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN3 GLIS3 SPATS2 FYB2	2.33e-04	159	84	4	50d951cf27a571c0c5002003c16fbc370fa17eb1
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	STOX2 VCAN GLIS3 LRRC4C	2.62e-04	164	84	4	1cb5fbd7050650047ad6f2ca792118e98d58d22b
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GLIS3 SPATS2 FYB2 CCSER1	2.62e-04	164	84	4	6fb2136168f430babfeb81ca7e151ca7a8092ec4
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-B_naive-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	PLEKHG1 EFCAB13 CD72 CCSER1	2.68e-04	165	84	4	8003fd2aa3f5c9d0e99054af4ad2d79a4a3c4829
ToppCell	Adult-Epithelial-lung_goblet_cell-D122\|Adult / Lineage, Cell type, age group and donor	TMEM130 SORBS2 KIAA1217 FYB2	2.80e-04	167	84	4	6efbb2ef6adc8da5dd67210969f825f5cc8ed022
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-8\|TCGA-Thryoid / Sample_Type by Project: Shred V9	PLEKHG1 TMEM130 GLDN PCDHGC5	2.87e-04	168	84	4	00646601548b0fee42ae16bfa5e93603bc7c5129
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPN3 SYTL2 POU3F4 FYB2	3.00e-04	170	84	4	928e42c51a7079c506f21c669c4e4c1a0df84d77
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	PLEKHG1 EFCAB13 CD72 CCSER1	3.07e-04	171	84	4	c3e3ea09c73050372314a89b282e36ba5f339d73
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	STOX2 KIAA1217 PLEKHA5 SLC44A3	3.21e-04	173	84	4	b799c06a6a5754668e789f70c0c8bc1508568575
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	SLC10A5 ZGRF1 OSBP2 SKA3	3.35e-04	175	84	4	fd8b5b756f3df4a04938785f3d9edbb6f1cd20f6
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|368C / Donor, Lineage, Cell class and subclass (all cells)	SLC10A5 ZGRF1 OSBP2 SKA3	3.35e-04	175	84	4	36c140540497bbe1c5f08fac2d94f08cac18fabb
ToppCell	pdx-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	CACNA1D SORBS2 EFCAB13 FYB2	3.42e-04	176	84	4	1e21f80cf0e695ffdd63e4a72cf1e3fa41b60341
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-4\|TCGA-Lung / Sample_Type by Project: Shred V9	VCAN SYTL2 GLIS3 RASSF4	3.42e-04	176	84	4	0923b01137d6f9956ca815b41102c81e82624065
Computational	Genes upregulated in subsets of cells of a given type within various tumors	KMT2C HIPK2 KMT2A ANKRD12	3.09e-05	49	40	4	GAVISH_3CA_MALIGNANT_METAPROGRAM_41_UNASSIGNED
Disease	delivery measurement, spontaneous preterm birth	CACNA1D GLIS3	7.82e-06	2	83	2	EFO_0006917, EFO_0006922
Disease	Kleefstra syndrome 2 (implicated_via_orthology)	KMT2C KMT2D	7.82e-06	2	83	2	DOID:0080598 (implicated_via_orthology)
Disease	cognitive function measurement	PLEKHG1 CACNA1D STOX2 CCDC195 KMT2D GLDN ALMS1 KIAA1217 ZDBF2 LMBRD2 KMT2E JMJD1C SLC44A3 CCSER1	4.37e-05	1434	83	14	EFO_0008354
Disease	Bladder Neoplasm	NAT1 KMT2C FBXW8 KMT2D KMT2A	4.83e-05	140	83	5	C0005695
Disease	Malignant neoplasm of urinary bladder	NAT1 KMT2C FBXW8 KMT2D KMT2A	4.99e-05	141	83	5	C0005684
Disease	thyroxine measurement	STARD9 ZGRF1 GLIS3 SIM1	9.03e-05	83	83	4	EFO_0005130
Disease	alkaline phosphatase measurement, liver enzyme measurement	GPLD1 JMJD1C	1.16e-04	6	83	2	EFO_0004533, EFO_0004582
Disease	Neurodevelopmental Disorders	KMT2C TNRC6B KMT2A KMT2E	1.40e-04	93	83	4	C1535926
Disease	Cornelia De Lange Syndrome	KMT2A NIPBL	2.16e-04	8	83	2	C0270972
Disease	esophagus squamous cell carcinoma (is_implicated_in)	KMT2C KMT2D RICTOR	2.80e-04	45	83	3	DOID:3748 (is_implicated_in)
Disease	smoking cessation	ZSWIM8 CCDC195 ALMS1 KIAA1217 LRRC4C JMJD1C	3.16e-04	325	83	6	EFO_0004319
Disease	eye colour measurement	PTPN3 STOX2 SORBS2 LRRC4C SIM1	3.82e-04	218	83	5	EFO_0009764
Disease	3-hydroxypropylmercapturic acid measurement	ELFN1 KIAA1217 ADAMTS20 KMT2A PLEKHA5 EMSY	4.82e-04	352	83	6	EFO_0007014
Disease	intracranial aneurysm (is_implicated_in)	KMT2D VCAN	5.07e-04	12	83	2	DOID:10941 (is_implicated_in)
Disease	methylcobalamin deficiency type cblE, response to antineoplastic agent	KMT2A CD72	5.98e-04	13	83	2	GO_0097327, MONDO_0009354
Disease	Malignant neoplasm of breast	KMT2D TMTC4 ZNF569 SMARCAL1 EFCAB13 TEKT4 SIK3 SIM1 NIPBL EMSY	8.58e-04	1074	83	10	C0006142
Disease	Autosome Abnormalities	NAT1 KMT2A	9.14e-04	16	83	2	C0004403
Disease	Chromosome Aberrations	NAT1 KMT2A	9.14e-04	16	83	2	C0008625
Disease	congenital heart disease (implicated_via_orthology)	KMT2C KMT2D KMT2A	9.84e-04	69	83	3	DOID:1682 (implicated_via_orthology)
Disease	prostate cancer (is_marker_for)	KMT2C KMT2D KMT2A KMT2E	9.99e-04	156	83	4	DOID:10283 (is_marker_for)
Disease	1-Methylhistidine measurement	SORBS2 ALMS1	1.03e-03	17	83	2	EFO_0021543
Disease	Myeloid Leukemia	KMT2A KMT2E	1.16e-03	18	83	2	C0023470
Disease	Leukemia, Monocytic, Chronic	KMT2A KMT2E	1.16e-03	18	83	2	C0023466
Disease	unipolar depression, response to bupropion, mood disorder	STOX2 CCDC195	1.30e-03	19	83	2	EFO_0003761, EFO_0004247, EFO_0006326
Disease	colorectal cancer, inflammatory bowel disease	ALMS1 PTCHD3	1.30e-03	19	83	2	EFO_0003767, MONDO_0005575
Disease	hippocampal volume	STOX2 FBXW8 KIAA1217 VCAN FYB2	1.53e-03	297	83	5	EFO_0005035
Disease	otosclerosis	ANAPC1 PEAK1 CCSER1	1.56e-03	81	83	3	EFO_0004213
Disease	skin hydration measurement	PLEKHG1 LRRC4C	1.59e-03	21	83	2	EFO_0009586
Disease	response to peginterferon alfa-2a	GLIS3 ANKRD26	2.25e-03	25	83	2	EFO_0010103
Disease	Cholangiocarcinoma	KMT2C PTPN3	2.43e-03	26	83	2	C0206698
Disease	hypertension, COVID-19	PLEKHG1 CACNA1D	2.62e-03	27	83	2	EFO_0000537, MONDO_0100096
Disease	Sezary Syndrome	KMT2C KMT2D	2.62e-03	27	83	2	C0036920

Protein segments in the cluster

Peptide	Gene	Start	Entry
NYTNSSTVHFKLSPT	AFDN	621	P55196
NTYLQTSPSSVFTSK	NAT1	206	P18440
SQLSPQYHSLSYSSS	ELFN1	751	P0C7U0
NTLYPHTSQVESTSS	VCAN	2281	P13611
QKTPSQTAFHSSYSQ	ALMS1	2036	Q8TCU4
QTAFHSSYSQTVKPN	ALMS1	2041	Q8TCU4
TFSVVQHVNTTYPKS	GLDN	456	Q6ZMI3
SSHYKFSKPVLQSQS	CCSER1	186	Q9C0I3
SKLATFSEIYPQSHS	CD72	266	P21854
ASTQLNTHYAFSKLT	ANKRD12	1596	Q6UB98
TSIKVQCFSHPTYQS	ANKRD26	326	Q9UPS8
SQIKETSLPFHTYSN	ADAMTS20	206	P59510
SRLHSYSSPSTKNSS	RBM15	121	Q96T37
HKTSVFTPAYGSVTN	RASSF4	176	Q9H2L5
AQSYLTQKSSSSVSP	PTPN3	446	P26045
TSPFQNYSSIHSQSR	ANAPC1	316	Q9H1A4
YAKTSSHSQPSPQSL	YWHAH-AS1	91	Q9Y442
LNAPYSKQFVHSKSS	KMT2C	4746	Q8NEZ4
SHSKVYSQSKNIPLS	HIPK2	46	Q9H2X6
LVPVNTSHHSSSYKS	HIPK2	986	Q9H2X6
QFAHQTYISASPAST	HIPK2	1166	Q9H2X6
RTENPKHSQYTSKSS	MAP10	731	Q9P2G4
AKETTSHNSLTTPCY	MAPKAPK2	211	P49137
SPYVKSSSSHNEVFL	JHY	226	Q6NUN7
HSPDSVKSKATYVNS	JMJD1C	651	Q15652
SSYSKNSSSLKHSPN	CCDC195	176	A0A1B0GUA6
GPVYSQSTALTHKQS	CAND1	781	Q86VP6
AITKQPSSTSYNFTS	FAM135A	1176	Q9P2D6
SFSSHSLITANVPYQ	FBXW8	521	Q8N3Y1
TTIPTKQTQTFTTYS	HSPA2	421	P54652
TVSFYTLSPNSHFSL	PCDHGC5	166	Q9Y5F6
QRSYSSSHSSPAKIQ	PEAK1	721	Q9H792
NYQQTTISHSPSSRF	NIPBL	141	Q6KC79
TIKSHSSLPPNNSYA	DAPK3	306	O43293
EKSNSYPHQLYTSSS	KMT2E	36	Q8IZD2
YKSPFNHTTTVNTIN	LRRC4C	601	Q9HCJ2
SSYSTTVHRIAKPFN	OSBP2	586	Q969R2
TKTIKTSHYLTPQSN	RICTOR	1261	Q6R327
SNPYSILSSTSLVHA	POU3F4	6	P49335
TQSFNNYSPNSHSSK	DNAJB7	241	Q7Z6W7
NYSPNSHSSKHVSQY	DNAJB7	246	Q7Z6W7
SGSHLKSYQPETNSS	GLIS3	646	Q8NEA6
NQYSVHKTSSPLCTS	EFCAB13	126	Q8IY85
SLKHSRSEPQYFSSA	KMT2A	621	Q03164
SLNSFNYTHSPKADS	SLC44A3	146	Q8N4M1
SSTFVPNILSKSHNY	EMSY	286	Q7Z589
SSKAQKYSPSHSTRS	CACNA1D	1966	Q01668
KTLNLSSISFPAYNH	PTCHD3	276	Q3KNS1
HISYAFVSSSQPSVN	PTCHD3	871	Q3KNS1
SNSHPLSLTSDQYKA	IRF3	396	Q14653
LFHQSTSSPYVSKSE	SYTL2	391	Q9HCH5
NSFPIHSSNSTKKTY	TAS2R39	186	P59534
FVYKETSLHSPSNTS	SYPL1	231	Q16563
VSSSQKYSNYTPSAQ	HSF5	286	Q4G112
HKYNTTSTSYSPLAS	PLAGL1	301	Q9UM63
SASVVFTTYTQKHPS	GET4	211	Q7L5D6
SISHKNTQPTAYTSI	LMBRD2	501	Q68DH5
SATYNGPKHSLTQIS	TAF1	1456	P21675
SSNHKQRTPYCSSSE	FYB2	56	Q5VWT5
KASPSGQNISYIHSS	SMARCAL1	196	Q9NZC9
QISASKPAFSYTSSS	SIM1	346	P81133
IHTPSLTSYKAQNGS	KIAA1217	1916	Q5T5P2
VQSSTYKDSNTLHLP	SIK3	601	Q9Y2K2
SQSTEVQAHPYSTTF	TEKT4	221	Q8WW24
QATKSLCHFYSSVSP	SH3TC2	961	Q8TF17
VQSPTKNHYTSSTSE	WDR17	331	Q8IZU2
SVYSSVTQNRHFLPS	STARD9	1846	Q9P2P6
VSSSYENKRPNSSHL	SLC10A5	46	Q5PT55
YSSDRIHSLSSNKPQ	SORBS2	1016	O94875
VSTNYPLSKTNSSSN	SKA3	306	Q8IX90
SSNTSHKSYRPLTVL	TMTC4	76	Q5T4D3
DSFGQVSHPKNSYST	SPATS2	366	Q86XZ4
NPSHFEKQYESSSSS	RPAP2	196	Q8IXW5
PLHSTLSVNSYHKSS	STOX2	706	Q9P2F5
SQKHVSSPLASYFLS	GPLD1	361	P80108
KISHSTQTSCKNYPV	ZDBF2	1941	Q9HCK1
STYKQHCRTPSSSST	TRAF7	51	Q6Q0C0
SQTHKPQTLSSFYSS	ZSWIM8	1016	A7E2V4
VKSYGNSSSHFVITP	ZNF569	171	Q5MCW4
QSPAHYKQTFTSCLI	ZGRF1	1291	Q86YA3
STLPSQATEKSSYFQ	ZNF212	21	Q9UDV6
PVSVASTAYNLTHTF	TMEM130	291	Q8N3G9
ISAKSQPYHRSQSSS	PLEKHG1	1171	Q9ULL1
SKTSNHYSLSTNSPP	TRIM64C	381	A6NLI5
FYNKQSTLPRHSTLS	PLEKHA5	511	Q9HAU0
VSYATTHSKASPRIQ	THEGL	406	P0DJG4
SHTQYTPFTSKGHRT	TEX13B	286	Q9BXU2
SFTNVHSTSAKFPDY	TNRC6B	1551	Q9UPQ9
ETNTPYSKQFVHSKS	KMT2D	5371	O14686
FVKLSTTYHSSPSST	MUC12	441	Q9UKN1