Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiondynein intermediate chain binding

PAFAH1B1 DNAH17 DNAH2 DNAH11

2.48e-0537924GO:0045505
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH17 DNAH2 DNAH11

7.35e-0518923GO:0008569
GeneOntologyMolecularFunctionryanodine-sensitive calcium-release channel activity

RYR1 RYR2

1.25e-044922GO:0005219
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH17 DNAH2 DNAH11

2.85e-0428923GO:0051959
GeneOntologyMolecularFunctioncalcium-induced calcium release activity

RYR1 RYR2

3.11e-046922GO:0048763
GeneOntologyMolecularFunctionligand-gated calcium channel activity

TRPM4 RYR1 RYR2

3.87e-0431923GO:0099604
GeneOntologyBiologicalProcessregulation of ventricular cardiac muscle cell action potential

TRPM4 DSP RYR2

1.66e-0512893GO:0098911
DomainSnAC

SMARCA2 SMARCA4

2.35e-052912SM01314
DomainGln-Leu-Gln_QLQ

SMARCA2 SMARCA4

2.35e-052912IPR014978
DomainSnAC

SMARCA2 SMARCA4

2.35e-052912IPR029295
DomainSnAC

SMARCA2 SMARCA4

2.35e-052912PF14619
DomainQLQ

SMARCA2 SMARCA4

2.35e-052912SM00951
DomainQLQ

SMARCA2 SMARCA4

2.35e-052912PS51666
DomainQLQ

SMARCA2 SMARCA4

2.35e-052912PF08880
DomainRyanrecept_TM4-6

RYR1 RYR2

7.02e-053912IPR009460
DomainRyR

RYR1 RYR2

7.02e-053912PF02026
DomainRyanodine_rcpt

RYR1 RYR2

7.02e-053912IPR003032
DomainRR_TM4-6

RYR1 RYR2

7.02e-053912PF06459
DomainRyan_recept

RYR1 RYR2

7.02e-053912IPR013333
DomainHSA

SMARCA2 SMARCA4

1.40e-044912SM00573
DomainHSA

SMARCA2 SMARCA4

1.40e-044912PS51204
DomainHSA_dom

SMARCA2 SMARCA4

1.40e-044912IPR014012
DomainHSA

SMARCA2 SMARCA4

1.40e-044912PF07529
DomainBromodomain_CS

SMARCA2 SMARCA4 BAZ1B

2.68e-0426913IPR018359
DomainDnaJ_domain_CS

DNAJC21 DNAJB8 DNAJB3

3.01e-0427913IPR018253
DomainBRK

SMARCA2 SMARCA4

3.48e-046912SM00592
DomainRIH_assoc

RYR1 RYR2

3.48e-046912PF08454
DomainRIH_assoc-dom

RYR1 RYR2

3.48e-046912IPR013662
DomainRIH_dom

RYR1 RYR2

3.48e-046912IPR000699
DomainIns145_P3_rcpt

RYR1 RYR2

3.48e-046912IPR014821
DomainRyanodine_recept-rel

RYR1 RYR2

3.48e-046912IPR015925
Domain-

RYR1 RYR2

3.48e-0469121.25.10.30
DomainBRK_domain

SMARCA2 SMARCA4

3.48e-046912IPR006576
DomainRYDR_ITPR

RYR1 RYR2

3.48e-046912PF01365
DomainBRK

SMARCA2 SMARCA4

3.48e-046912PF07533
DomainIns145_P3_rec

RYR1 RYR2

3.48e-046912PF08709
DomainDHC_N1

DNAH2 DNAH11

6.45e-048912PF08385
DomainDynein_heavy_dom-1

DNAH2 DNAH11

6.45e-048912IPR013594
DomainBROMODOMAIN_1

SMARCA2 SMARCA4 BAZ1B

7.71e-0437913PS00633
DomainBromodomain

SMARCA2 SMARCA4 BAZ1B

8.34e-0438913PF00439
DomainMIR

RYR1 RYR2

1.03e-0310912PS50919
DomainMIR

RYR1 RYR2

1.03e-0310912PF02815
DomainMIR

RYR1 RYR2

1.03e-0310912SM00472
DomainMIR_motif

RYR1 RYR2

1.03e-0310912IPR016093
DomainBROMODOMAIN_2

SMARCA2 SMARCA4 BAZ1B

1.04e-0341913PS50014
DomainBROMO

SMARCA2 SMARCA4 BAZ1B

1.12e-0342913SM00297
DomainBromodomain

SMARCA2 SMARCA4 BAZ1B

1.12e-0342913IPR001487
Domain-

SMARCA2 SMARCA4 BAZ1B

1.12e-03429131.20.920.10
DomainDnaJ

DNAJC21 DNAJB8 DNAJB3

1.65e-0348913PF00226
DomainDNAJ_1

DNAJC21 DNAJB8 DNAJB3

1.75e-0349913PS00636
DomainDNAJ_2

DNAJC21 DNAJB8 DNAJB3

1.75e-0349913PS50076
DomainDnaJ

DNAJC21 DNAJB8 DNAJB3

1.75e-0349913SM00271
Domain-

DNAJC21 DNAJB8 DNAJB3

1.75e-03499131.10.287.110
DomainDnaJ_domain

DNAJC21 DNAJB8 DNAJB3

1.97e-0351913IPR001623
DomainDynein_heavy_chain_D4_dom

DNAH2 DNAH11

2.06e-0314912IPR024317
DomainDynein_HC_stalk

DNAH2 DNAH11

2.06e-0314912IPR024743
DomainDynein_heavy_dom-2

DNAH2 DNAH11

2.06e-0314912IPR013602
DomainDHC_N2

DNAH2 DNAH11

2.06e-0314912PF08393
DomainMT

DNAH2 DNAH11

2.06e-0314912PF12777
DomainAAA_8

DNAH2 DNAH11

2.06e-0314912PF12780
DomainATPase_dyneun-rel_AAA

DNAH2 DNAH11

2.06e-0314912IPR011704
DomainAAA_5

DNAH2 DNAH11

2.06e-0314912PF07728
DomainDHC_fam

DNAH2 DNAH11

2.37e-0315912IPR026983
DomainDynein_heavy_dom

DNAH2 DNAH11

2.37e-0315912IPR004273
DomainDynein_heavy

DNAH2 DNAH11

2.37e-0315912PF03028
DomainMyosin-like_IQ_dom

ASPM MYO18B

3.80e-0319912IPR027401
Domain-

ASPM MYO18B

3.80e-03199124.10.270.10
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

MYOF TRMT10C VRK2 DSP TBK1 PAFAH1B1 CLTA SRP68 STARD7 MRPL40 HAGH GALNT7 TRRAP CNOT1 YARS1 TFRC

3.25e-071297931633545068
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

RINT1 TRMT10C VRK2 MOSPD2 TCHP MRPL47 SYNE1 RAB3GAP2 BAG4 CLTA ASPM BAZ1B DNAJC21 MRPL40 DNAJB8 DNAJB3 TFRC

3.86e-071487931733957083
Pubmed

Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.

DNAH17 DNAH2 DNAH11

6.43e-07793331178125
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

MYOF SETD2 DSP PODXL SYNE1 EIF4G1 DNAH2 SMARCA4 BAZ1B SRP68 TRRAP YARS1

8.28e-07754931235906200
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

FARSA TRMT10C DSP SUPT5H SYNE1 RAB3GAP2 TBK1 CLTA EIF4G1 SMARCA4 BAZ1B SRP68 MYO18B CNOT1 YARS1 TFRC

1.13e-061425931630948266
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

FARSA RINT1 VRK2 RAB3GAP2 TBK1 BAG4 EIF4G1 DNAH2 SRP68 TSC2 GALNT7 TARBP1 TFRC

1.37e-06942931331073040
Pubmed

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.

RINT1 MAP7D1 PPP2R2D DSP SMARCA4 XPO4 SRP68 CNOT1 ZBTB24 YARS1 TFRC

1.51e-06657931136180527
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

VLDLR SETD2 INTU MAP7D1 SAT1 TBK1 BAG4 IYD ASPM SMARCA2 SMARCA4 BAZ1B TRRAP ISY1

1.59e-061116931431753913
Pubmed

BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation.

SMARCA2 SMARCA4 TRRAP

2.19e-061093311839798
Pubmed

The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets.

AGAP5 SAT1 SUPT5H SMARCA2 SMARCA4 DNAJC21 MRPL40

2.55e-0622593725277244
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

FARSA TRMT10C MAP7D1 PPP2R2D TBK1 CLTA EIF4G1 SMARCA2 SRP68 MRPL40 TRRAP CNOT1 TARBP1

2.78e-061005931319615732
Pubmed

Targeting HIV transcription: the quest for a functional cure.

SUPT5H SMARCA2 SMARCA4

3.01e-061193325731772
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

FARSA TRMT10C MAP7D1 DSP MRPL47 EIF4G1 SMARCA4 SRP68 STARD7 TSC2 HAGH TARBP1 ISY1 YARS1 TFRC

5.09e-061415931528515276
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

SETD2 FARSA TRMT10C DSP SUPT5H SYNE1 EIF4G1 SMARCA4 SRP68 MRPL40 PCDHA1 TRRAP CNOT1

6.18e-061082931338697112
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DNAH17 DNAH2 DNAH11

6.60e-06149339373155
Pubmed

The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis.

SMARCA2 SMARCA4

7.07e-0629328670841
Pubmed

Lung cancer with loss of BRG1/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features.

SMARCA2 SMARCA4

7.07e-06293223163725
Pubmed

Combined gene dosage requirement for SWI/SNF catalytic subunits during early mammalian development.

SMARCA2 SMARCA4

7.07e-06293223076393
Pubmed

Differential preimplantation regulation of two mouse homologues of the yeast SWI2 protein.

SMARCA2 SMARCA4

7.07e-0629329603422
Pubmed

The SWI/SNF chromatin remodeling protein Brg1 is required for vertebrate neurogenesis and mediates transactivation of Ngn and NeuroD.

SMARCA2 SMARCA4

7.07e-06293215576411
Pubmed

Bifunctional Aptamer-Doxorubicin Conjugate Crosses the Blood-Brain Barrier and Selectively Delivers Its Payload to EpCAM-Positive Tumor Cells.

EPCAM TFRC

7.07e-06293232027209
Pubmed

SWI/SNF gene variants and glioma risk and outcome.

SMARCA2 SMARCA4

7.07e-06293223276717
Pubmed

Differential Expression of SWI/SNF Chromatin Remodeler Subunits Brahma and Brahma-Related Gene During Drug-Induced Liver Injury and Regeneration in Mouse Model.

SMARCA2 SMARCA4

7.07e-06293227097303
Pubmed

Chromatin remodeling factors and BRM/BRG1 expression as prognostic indicators in non-small cell lung cancer.

SMARCA2 SMARCA4

7.07e-06293215240517
Pubmed

Concomitant loss of SMARCA2 and SMARCA4 expression in small cell carcinoma of the ovary, hypercalcemic type.

SMARCA2 SMARCA4

7.07e-06293226564006
Pubmed

SMARCA4/SMARCA2-deficient Carcinoma of the Esophagus and Gastroesophageal Junction.

SMARCA2 SMARCA4

7.07e-06293233027072
Pubmed

SMARCA4 and SMARCA2 deficiency in non-small cell lung cancer: immunohistochemical survey of 316 consecutive specimens.

SMARCA2 SMARCA4

7.07e-06293228038711
Pubmed

A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1.

SMARCA2 SMARCA4

7.07e-06293223872584
Pubmed

Proinflammatory stimuli engage Brahma related gene 1 and Brahma in endothelial injury.

SMARCA2 SMARCA4

7.07e-06293223963727
Pubmed

Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.

RYR1 RYR2

7.07e-06293217259277
Pubmed

SW13 cells can transition between two distinct subtypes by switching expression of BRG1 and Brm genes at the post-transcriptional level.

SMARCA2 SMARCA4

7.07e-06293212493776
Pubmed

Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4.

SMARCA2 SMARCA4

7.07e-06293231375262
Pubmed

Alterations of the SWI/SNF chromatin remodelling subunit-BRG1 and BRM in hepatocellular carcinoma.

SMARCA2 SMARCA4

7.07e-06293223088494
Pubmed

Aberrant expression of SWI/SNF catalytic subunits BRG1/BRM is associated with tumor development and increased invasiveness in prostate cancers.

SMARCA2 SMARCA4

7.07e-06293217075831
Pubmed

Ryanodine receptor oligomeric interaction: identification of a putative binding region.

RYR1 RYR2

7.07e-06293214722100
Pubmed

SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells.

SMARCA2 SMARCA4

7.07e-06293220333683
Pubmed

SWI/SNF Complex-deficient Undifferentiated Carcinoma of the Gastrointestinal Tract: Clinicopathologic Study of 30 Cases With an Emphasis on Variable Morphology, Immune Features, and the Prognostic Significance of Different SMARCA4 and SMARCA2 Subunit Deficiencies.

SMARCA2 SMARCA4

7.07e-06293234812766
Pubmed

Structural and functional interactions within ryanodine receptor.

RYR1 RYR2

7.07e-06293226009179
Pubmed

Loss of SWI/SNF Chromatin Remodeling Alters NRF2 Signaling in Non-Small Cell Lung Carcinoma.

SMARCA2 SMARCA4

7.07e-06293232855269
Pubmed

Targeting of BRM Sensitizes BRG1-Mutant Lung Cancer Cell Lines to Radiotherapy.

SMARCA2 SMARCA4

7.07e-06293230478150
Pubmed

Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies-Present State, Challenges, and Perspectives.

RYR1 RYR2

7.07e-06293232899693
Pubmed

Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity.

SMARCA2 SMARCA4

7.07e-06293222721696
Pubmed

Chromatin remodeling complexes interact dynamically with a glucocorticoid receptor-regulated promoter.

SMARCA2 SMARCA4

7.07e-06293218508913
Pubmed

Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling.

SMARCA2 SMARCA4

7.07e-06293211719516
Pubmed

Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.

RYR1 RYR2

7.07e-06293230542613
Pubmed

The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation.

SMARCA2 SMARCA4

7.07e-06293225808524
Pubmed

Antagonistic roles for BRM and BRG1 SWI/SNF complexes in differentiation.

SMARCA2 SMARCA4

7.07e-06293219144648
Pubmed

DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes.

SMARCA2 SMARCA4

7.07e-06293228706277
Pubmed

Ryanodine receptors are expressed and functionally active in mouse spermatogenic cells and their inhibition interferes with spermatogonial differentiation.

RYR1 RYR2

7.07e-06293215280431
Pubmed

Expression of the ryanodine receptor isoforms in immune cells.

RYR1 RYR2

7.07e-06293211673493
Pubmed

B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators.

RYR1 RYR2

7.07e-06293211673462
Pubmed

[Expression of BRG1 and BRM proteins in prostatic cancer].

SMARCA2 SMARCA4

7.07e-06293221092585
Pubmed

High expression of SMARCA4 or SMARCA2 is frequently associated with an opposite prognosis in cancer.

SMARCA2 SMARCA4

7.07e-06293229391527
Pubmed

Expression of SMARCA2 and SMARCA4 in gastric adenocarcinoma and construction of a nomogram prognostic model.

SMARCA2 SMARCA4

7.07e-06293237634210
Pubmed

SWI/SNF Complex-deficient Undifferentiated/Rhabdoid Carcinomas of the Gastrointestinal Tract: A Series of 13 Cases Highlighting Mutually Exclusive Loss of SMARCA4 and SMARCA2 and Frequent Co-inactivation of SMARCB1 and SMARCA2.

SMARCA2 SMARCA4

7.07e-06293226551623
Pubmed

SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity.

SMARCA2 SMARCA4

7.07e-06293219458193
Pubmed

Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.

RYR1 RYR2

7.07e-06293225370123
Pubmed

Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor.

SMARCA2 SMARCA4

7.07e-0629328208605
Pubmed

Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.

RYR1 RYR2

7.07e-06293215033925
Pubmed

The Bromodomains of the mammalian SWI/SNF (mSWI/SNF) ATPases Brahma (BRM) and Brahma Related Gene 1 (BRG1) promote chromatin interaction and are critical for skeletal muscle differentiation.

SMARCA2 SMARCA4

7.07e-06293234289068
Pubmed

SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria.

SMARCA2 SMARCA4

7.07e-06293234518526
Pubmed

SMARCA family of genes.

SMARCA2 SMARCA4

7.07e-06293232312722
Pubmed

Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type.

SMARCA2 SMARCA4

7.07e-06293226356327
Pubmed

Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels.

RYR1 RYR2

7.07e-06293218618700
Pubmed

Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis.

SMARCA2 SMARCA4

7.07e-06293212566296
Pubmed

A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes.

SMARCA2 SMARCA4

7.07e-06293211163203
Pubmed

Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes.

SMARCA2 SMARCA4

7.07e-06293212620226
Pubmed

SMARCA2-deficiency confers sensitivity to targeted inhibition of SMARCA4 in esophageal squamous cell carcinoma cell lines.

SMARCA2 SMARCA4

7.07e-06293231406271
Pubmed

BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo.

SMARCA2 SMARCA4

7.07e-06293227039070
Pubmed

Partial Inactivation of the Chromatin Remodelers SMARCA2 and SMARCA4 in Virus-Infected Cells by Caspase-Mediated Cleavage.

SMARCA2 SMARCA4

7.07e-06293229848589
Pubmed

Co-regulation of transcription by BRG1 and BRM, two mutually exclusive SWI/SNF ATPase subunits.

SMARCA2 SMARCA4

7.07e-06293229273066
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

CLTA DNAH2 SMARCA2 SRP68 LMOD2 CNOT1 TARBP1 RYR1 RYR2 DNAH11

8.29e-06638931031182584
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

TRPM4 MYOF SETD2 FARSA TRMT10C VRK2 MAP7D1 MRPL47 SYNE1 EIF4G1 SMARCA2 BAZ1B DNAJC21 SRP68 TRRAP

9.98e-061497931531527615
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

MYOF TRMT10C PTGR1 DSP PODXL SUPT5H PAFAH1B1 CLTA EIF4G1 SMARCA2 SRP68 HAGH CNOT1 TFRC

1.60e-051367931432687490
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

SETD2 FARSA PTGR1 SUPT5H EIF4G1 SMARCA2 SMARCA4 BAZ1B TRRAP ISY1 YARS1 TFRC

1.68e-051014931232416067
Pubmed

ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.

DSP TSC2 RYR1 RYR2

1.70e-055793423788249
Pubmed

Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models.

SMARCA2 SMARCA4

2.12e-05393228292935
Pubmed

Clinicopathological and prognostic significance of SWI/SNF complex subunits in undifferentiated gastric carcinoma.

SMARCA2 SMARCA4

2.12e-05393236464671
Pubmed

Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.

RYR1 RYR2

2.12e-05393218403125
Pubmed

DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1.

SMARCA2 SMARCA4

2.12e-05393230287812
Pubmed

Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.

RYR1 RYR2

2.12e-05393218434746
Pubmed

SPRY domains in ryanodine receptors (Ca(2+)-release channels).

RYR1 RYR2

2.12e-0539329204703
Pubmed

The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.

RYR1 RYR2

2.12e-0539327876312
Pubmed

Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.

RYR1 RYR2

2.12e-05393221881589
Pubmed

Dendritic differentiation of cerebellar Purkinje cells is promoted by ryanodine receptors expressed by Purkinje and granule cells.

RYR1 RYR2

2.12e-05393224123915
Pubmed

Dynamics and unexpected localization of the plakin binding protein, kazrin, in mouse eggs and early embryos.

DSP KAZN

2.12e-05393216086310
Pubmed

Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).

RYR1 RYR2

2.12e-05393212213830
Pubmed

The activity of p53 is differentially regulated by Brm- and Brg1-containing SWI/SNF chromatin remodeling complexes.

SMARCA2 SMARCA4

2.12e-05393217938176
Pubmed

Dopamine D1 receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence.

RYR1 RYR2

2.12e-05393223278119
Pubmed

Functional redundancy of SWI/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heart.

SMARCA2 SMARCA4

2.12e-05393222740088
Pubmed

Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.

RYR1 RYR2

2.12e-0539329242641
Pubmed

BRCA1 interacts with dominant negative SWI/SNF enzymes without affecting homologous recombination or radiation-induced gene activation of p21 or Mdm2.

SMARCA2 SMARCA4

2.12e-05393215034933
Pubmed

TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival.

SMARCA2 SMARCA4

2.12e-05393215075294
Pubmed

Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.

RYR1 RYR2

2.12e-05393222948152
Pubmed

Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.

RYR1 RYR2

2.12e-05393223454728
Pubmed

Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.

RYR1 RYR2

2.12e-05393210788707
Pubmed

A putative nuclear receptor coactivator (TMF/ARA160) associates with hbrm/hSNF2 alpha and BRG-1/hSNF2 beta and localizes in the Golgi apparatus.

SMARCA2 SMARCA4

2.12e-05393212044884
Pubmed

SWI/SNF complexes containing Brahma or Brahma-related gene 1 play distinct roles in smooth muscle development.

SMARCA2 SMARCA4

2.12e-05393221518954
Pubmed

Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.

RYR1 RYR2

2.12e-05393225239916
Pubmed

Heterogeneous SWI/SNF chromatin remodeling complexes promote expression of microphthalmia-associated transcription factor target genes in melanoma.

SMARCA2 SMARCA4

2.12e-05393219784067
InteractionCNTROB interactions

TCHP DSP TBK1 EIF4G1 SMARCA2 TRRAP CNOT1

9.54e-06166907int:CNTROB
GeneFamilyDyneins, axonemal

DNAH17 DNAH2 DNAH11

2.78e-0517643536
GeneFamilyRyanodine receptors|Protein phosphatase 1 regulatory subunits

RYR1 RYR2

3.69e-053642287
GeneFamilySPOUT methyltranferase domain containing

TRMT10C TARBP1

3.41e-0486421294
GeneFamilyDNAJ (HSP40) heat shock proteins|C2 tensin-type domain containing

DNAJC21 DNAJB8 DNAJB3

6.94e-0449643584
GeneFamilyX-linked mental retardation|Rho GTPase activating proteins|BAR-PH domain containing

AGAP5 AGAP11

1.62e-03176421291
ToppCelldroplet-Heart-nan-3m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VLDLR DSP MYO18B LMOD2 RYR2 TFRC

3.03e-0619193697fb4232417a39801e87725755fd16a57c250209
ToppCelldroplet-Heart-nan-3m-Mesenchymal-cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VLDLR DSP MYO18B LMOD2 RYR2 TFRC

3.03e-0619193664070a309d7e3f6001272409ab9ce206d0e7d73f
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ABCA5 SYNE1 RAPGEF4 KAZN TARBP1 RYR2

3.73e-061989364ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellfacs-Lung-EPCAM-18m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM4 GALK2 XPO4 CNOT1 TARBP1

2.88e-0517093512203d4410f38cc933d9f160b5fb76828df94119
ToppCellfacs-Lung-EPCAM-18m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM4 GALK2 XPO4 CNOT1 TARBP1

2.88e-05170935f9decb3bf3bf6d4996b0ac27af768236e116aac5
ToppCellHealthy/Control-Plasmablast|World / Disease group and Cell class

ASPM KCNN3 MANEA KAZN EPCAM

3.05e-05172935d3bfcf5d936152b71cd90f955f9331709edd979e
ToppCellCOVID-19_Mild-PLT_2|COVID-19_Mild / Disease Group and Platelet Clusters

S100A13 MYOF TOPAZ1 TSC2 TARBP1

3.14e-05173935d11705e56b6b21eec963ea224717f27680c781ed
ToppCelldroplet-Lung-nan-21m-Myeloid-Proliferating_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASPM EPCAM RYR1 TFRC C4orf46

3.14e-051739352eb6e9fc3a3654f6f86fbd112e80a18814afd103
ToppCellHealthy/Control-Plasmablast|Healthy/Control / Disease group and Cell class

ASPM KCNN3 MANEA KAZN EPCAM

3.22e-0517493597d19ef3240a1f648c6befaabb9ce45ad469cbce
ToppCellfacs-Trachea-24m-Epithelial-glandular_epithelial|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IYD DHX32 LMOD2 EPCAM PRLR

4.21e-0518493561caaa31975e05c9a6512079c791fed5a9e2d39f
ToppCellfacs-Trachea-24m-Epithelial-glandular_epithelial-lung_secretory_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IYD DHX32 LMOD2 EPCAM PRLR

4.21e-0518493503da0f0f89f1ca5a3ccca1e22972f3129464e68e
ToppCellfacs-Trachea-24m-Epithelial-glandular_epithelial-lung_secretory_cell-mucous|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IYD DHX32 LMOD2 EPCAM PRLR

4.21e-051849359ed2a65a4ca0ebbbb89ace61027522f93369843d
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Lymphocytic-T_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TFEC FARSA ASPM XPO4 ZFP92

4.21e-05184935185b49630da61cbf45c0926d1b992943296d2a54
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

S100A13 INTU SYNE1 EPCAM DNAH11

4.90e-05190935b855b8b7d3439023390ca44629c1a99f5d4c6801
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

S100A13 INTU SYNE1 EPCAM DNAH11

4.90e-05190935a5db902ad112a0c0a0a7f1a2e38718bb3bd11412
ToppCelldroplet-Heart-4Chambers-21m-Mesenchymal-cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VLDLR DSP MYO18B LMOD2 RYR2

5.02e-05191935c172c9e17b893b290e4aa8af5e5e4cd3e4818372
ToppCelldroplet-Heart-4Chambers-21m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VLDLR DSP MYO18B LMOD2 RYR2

5.02e-05191935715f5b449b8e075959c05a5b38389df319663164
ToppCelldroplet-Heart-nan-18m-Mesenchymal-cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VLDLR DSP MYO18B LMOD2 RYR2

5.15e-051929350bf99e029a06151092db1e8a0dcb45f4e688e771
ToppCelldroplet-Heart-nan-18m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VLDLR DSP MYO18B LMOD2 RYR2

5.15e-05192935d766221acfce30cbf2c60b3ae40f6744968b952c
ToppCellfacs-Trachea-3m-Epithelial-glandular_epithelial-lung_secretory_cell-mucous|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DSP IYD LMOD2 EPCAM PRLR

5.28e-05193935c5925b3b5d19098e3987789d68a493d7fd548ac9
ToppCellfacs-Trachea-3m-Epithelial-glandular_epithelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DSP IYD LMOD2 EPCAM PRLR

5.28e-051939356905de261d90dfe3dd2c2cf5b2e26afb2bcc3d5b
ToppCellfacs-Trachea-3m-Epithelial-glandular_epithelial-lung_secretory_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DSP IYD LMOD2 EPCAM PRLR

5.28e-05193935f73630725f093c646bdaf178c39505c04a16e2c6
ToppCelldroplet-Trachea-3m-Epithelial-airway_epithelial-epithelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DSP IYD LMOD2 EPCAM PRLR

5.54e-051959354d7ca21f14730e1b6d0473bc1a11aa626db948f3
ToppCelldroplet-Trachea-3m-Epithelial-airway_epithelial-epithelial_cell-epithelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DSP IYD LMOD2 EPCAM PRLR

5.54e-051959358727554ef047ca7f1d4b888a8468f148c64a6918
ToppCelldroplet-Trachea-nan-3m-Epithelial-epithelial_cell|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSP IYD LMOD2 EPCAM PRLR

5.54e-051959359f0ee826d4f0997aee8d63284ed24549bbdf6a28
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ABCA5 SYNE1 RAPGEF4 TARBP1 RYR2

5.68e-05196935676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCelldroplet-Heart-HEART-1m-Mesenchymal-cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSP MYO18B LMOD2 RYR2 TFRC

5.68e-05196935a582130862bee76c0385156a333bfdfc75cf218b
ToppCelldroplet-Heart-HEART-1m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSP MYO18B LMOD2 RYR2 TFRC

5.68e-05196935fba52a4b82086dbae9a55038bf44c4539be926f5
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

INTU SYNE1 DNAH2 KCNN3 DNAH11

5.82e-0519793574a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ABCA5 SYNE1 RAPGEF4 TARBP1 RYR2

5.96e-051989356d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ABCA5 RAPGEF4 KAZN TARBP1 RYR2

5.96e-051989350ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellcontrol-Epithelial|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

S100A13 MYOF SAT1 DSP EPCAM

6.25e-05200935f95bbb94e51ac28b1995026c599ec3a34e012916
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

ABCA5 SYNE1 RAPGEF4 TARBP1 RYR2

6.25e-0520093548d801219bc771d6c7e151dc88ca4c179988de85
Diseasecongenital myopathy 1A (implicated_via_orthology)

RYR1 RYR2

2.63e-053882DOID:3529 (implicated_via_orthology)
Diseasemalignant hyperthermia (implicated_via_orthology)

RYR1 RYR2

2.63e-053882DOID:8545 (implicated_via_orthology)
DiseaseMENTAL RETARDATION, AUTOSOMAL DOMINANT 12

SMARCA2 SMARCA4

8.74e-055882C3281201
Diseaseopportunistic bacterial infectious disease (implicated_via_orthology)

SMARCA2 SMARCA4

3.12e-049882DOID:0050340 (implicated_via_orthology)
Diseasecerebral palsy (implicated_via_orthology)

AGAP5 AGAP11

3.90e-0410882DOID:1969 (implicated_via_orthology)
Diseasearrhythmogenic right ventricular cardiomyopathy (is_implicated_in)

DSP RYR2

3.90e-0410882DOID:0050431 (is_implicated_in)
DiseaseEpithelioid Cell Uveal Melanoma

VRK2 XPO4

4.75e-0411882EFO_1000244
DiseaseCoffin-Siris syndrome

SMARCA2 SMARCA4

6.71e-0413882C0265338
DiseaseAlpha ketoglutarate measurement

VLDLR SRP68

1.03e-0316882EFO_0010457
Diseasesusceptibility to mononucleosis measurement

DNAH2 MANEA RYR2

1.16e-0369883EFO_0008403
Diseaseleft atrial function

DSP MYO18B

1.78e-0321882EFO_0004294
Diseasetrans fatty acid measurement, trans/trans-18:2 fatty acid measurement

INTU MYO18B

2.33e-0324882EFO_0006821, EFO_0006826
DiseaseHereditary Nonpolyposis Colorectal Neoplasms

SMARCA4 EPCAM

2.73e-0326882C0009405
Diseasealcohol use disorder (implicated_via_orthology)

SMARCA2 SMARCA4 RYR1 RYR2

2.80e-03195884DOID:1574 (implicated_via_orthology)
Diseaseomega-6 polyunsaturated fatty acid measurement

NTAN1 SMARCA4 DNAJB8 DNAH11

2.90e-03197884EFO_0005680
DiseaseHereditary non-polyposis colorectal cancer syndrome

SMARCA4 EPCAM

2.94e-0327882C1112155

Protein segments in the cluster

PeptideGeneStartEntry
AELLLKLKWYDKAEK

TTC21B

796

Q7Z4L5
KGYFLEIKLKDWIEN

ABCA5

1526

Q8WWZ7
DKAYWLLEEMLTKEL

BAG4

406

O95429
TYWIIIELKHKAREK

EPCAM

141

P16422
EKERWIRSKYEHKLF

AGAP11

426

Q8TF27
LVQKRYELLEHKKRW

BAZ1B

521

Q9UIG0
KTWRDLLKEGYDSLK

C4orf46

96

Q504U0
KEIKLLKGLWDVIIY

DNAH11

1321

Q96DT5
KLWKISERDKRAEGY

PPP2R2D

126

Q66LE6
KLLIELEDWSDKKVY

ANGPTL1

366

O95841
LKEREDLPIWKEKYS

DHX32

56

Q7L7V1
PEDIKKAYRKLALRW

DNAJB8

16

Q8NHS0
RLIQTTWRKYKLKTD

ASPM

1271

Q8IZT6
KYAGLLEKKWTSVIR

PAFAH1B1

46

P43034
RWLKYLEKDSQELEL

MRNIP

106

Q6NTE8
LDTEYWKLLLKQLED

RAB3GAP2

881

Q9H2M9
AKDVYERLKDKWDEL

PODXL

421

O00592
IYSLRNKEVKSALWK

OR5B21

286

A6NL26
RVLKWVRDIDLKEYA

KAZN

616

Q674X7
WLLRLEEYTEKKKNQ

MGME1

321

Q9BQP7
IREKLAWAKEKYSIG

HAGH

241

Q16775
EYEKKLRAELVEKWK

ISY1

176

Q9ULR0
AYWEKESQKLLEKER

LMOD2

71

Q6P5Q4
SWDFKKIEKLEEYRL

DDX58

91

O95786
LRETWLIYKHTKLLK

KCNN3

576

Q9UGI6
LIYSLRNKEIKDALW

OR5A1

291

Q8NGJ0
KYKSLQWDKVLRLEE

GALK2

256

Q01415
AKKILDIKGIDYWLA

LALBA

111

P00709
FWKKLTLLDALYEIA

JRKL

356

Q9Y4A0
EEELKKAYRKLALKW

DNAJC21

16

Q5F1R6
LLLKYILDSWKKHDS

IRGC

446

Q6NXR0
LELTRKWSEKYSKER

MANEA

436

Q5SRI9
DELSKSLWLELRKYL

PCDHA1

186

Q9Y5I3
VAYWKESDKLLLIGL

INTU

376

Q9ULD6
WIKNKYRSELKAIRL

DNAH17

3451

Q9UFH2
SEAIKKAYRKLALKW

DNAJB3

16

Q8WWF6
EKLDEYIKLWNGLVK

GALNT7

256

Q86SF2
YRWQLDKIKADLREK

DSP

231

P15924
KIEWEKELYDLRLAL

CCDC144B

691

Q3MJ40
WKPLNLEEKKRYDRE

EIF4G1

601

Q04637
REERAKYLAAKKAVW

MAP7D1

146

Q3KQU3
KIEWEKELYDLRLAL

CCDC144A

691

A2RUR9
LTKLAKEYKDRNWEI

DNAH2

1271

Q9P225
DKEIYRWPIKESLKA

RYR1

2801

P21817
KLLSEKEKEIYRWPI

RYR2

2761

Q92736
DLLKWVLEGKIQYKE

PTGR1

286

Q14914
TDLKKLRTNWIKEYL

IYD

171

Q6PHW0
YWLNKDKVAIKTIRE

ITK

381

Q08881
TILDKKKLIAFWLER

MOSPD2

121

Q8NHP6
KKLIAFWLERYAKRE

MOSPD2

126

Q8NHP6
KEYEGNLTWKIKLRS

TAS2R31

156

P59538
TERRALLLKKWSLYK

MRPL40

111

Q9NQ50
LRIEQKDFKALWEKY

RAPGEF4

136

Q8WZA2
KLKEILKERELKIYW

YARS1

26

P54577
EYIIKDKHILAKIRW

SMARCA2

831

P51531
KRKLLAEVTLKTYWV

FARSA

161

Q9Y285
LVLAESKLKSWIIKY

SYNE1

516

Q8NF91
YWRLIGELAKEIRKK

S100A13

76

Q99584
EYIIKDKHILAKIRW

SMARCA4

861

P51532
EEGWRLFKIDKEYLL

SAT1

151

P21673
KSWVRLKRGIYKDDI

SUPT5H

276

O00267
ALLYKKNEDGLWEKI

NTAN1

291

Q96AB6
EDLHKLWYVLLKERN

MRPL47

96

Q9HD33
RLYWDDLKRKLSEKL

TFRC

121

P02786
VKKWSEALVLYDRVL

SRP68

476

Q9UHB9
IKYDILTKSSLKWRE

BCO1

436

Q9HAY6
EEKERWIRSKYEEKL

AGAP5

561

A6NIR3
KEKAIKELEEWYARQ

CLTA

136

P09496
KRDLVLVKEALSWYD

CLEC20A

21

Q6ZU45
RREYLKLDKWLTDKI

CNOT1

591

A5YKK6
LLWYLKELRKEEFWK

NLRP9

11

Q7RTR0
KELRKEEFWKFKELL

NLRP9

16

Q7RTR0
TEWKLLDLRQKVLYK

ZFP92

26

A6NM28
FLKRWAKTYLLVDEK

XPO4

641

Q9C0E2
REVKDAAKLYKKERW

RINT1

616

Q6NUQ1
LAWDKDLRVSDKYLL

SPDYE1

171

Q8NFV5
LLYEIRLKPEKAAEW

PRLR

166

P16471
RKLIAEQLLYEHWKK

TCHP

131

Q9BT92
KLLDSWKDLKEVYRI

SETD2

2011

Q9BYW2
WKLPSLDYERKTKVD

MYO18B

2426

Q8IUG5
RRIWRSVKLKDYKLV

ZBTB24

256

O43167
KWRSLEKRADEVVKY

ZSWIM2

281

Q8NEG5
LQWSKGRKVLEKLYE

TOPAZ1

1376

Q8N9V7
EEWALLDISQRKLYK

ZNF69

36

Q9UC07
TEYRKKWDALVIKLE

STARD7

186

Q9NQZ5
ILKASVEYIKWLQKE

TFEC

181

O14948
KKDELLKFWENYILI

TARBP1

321

Q13395
WLLKAKDHLKIYLQE

ZFYVE26

2291

Q68DK2
RELVKRYQEKWDKLL

TRMT10C

256

Q7L0Y3
NESKSRKYLAKVLWL

TRRAP

3191

Q9Y4A5
IKKWIERKQLDYLGI

VRK2

86

Q86Y07
VYLSKEAERKLLTWE

TRPM4

1111

Q8TD43
RKILREYKVSDKTWE

ZNF248

321

Q8NDW4
KGIRWLIELIKDDYN

TBK1

441

Q9UHD2
IKKYRKELQVVAWDI

TSC2

346

P49815
TLDLIKSRLYWLDSK

VLDLR

606

P98155
EKIKLTIYDWDRLTK

MYOF

436

Q9NZM1