Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	CUL2 PRAMEF5 PRAMEF26 PRAMEF6	1.74e-05	47	69	4	GO:0031462
MousePheno	abnormal synapse morphology	CACNB4 SETX KIF1A NEMF DAG1 SLC17A7 SLITRK3	2.94e-05	224	56	7	MP:0009538
Domain	PLipase_C_Pinositol-sp_Y	PLCB4 PLCD1	1.29e-03	15	67	2	IPR001711
Domain	EF-hand_like	PLCB4 PLCD1	1.29e-03	15	67	2	PF09279
Domain	PIPLC_Y_DOMAIN	PLCB4 PLCD1	1.29e-03	15	67	2	PS50008
Domain	PI-PLC_fam	PLCB4 PLCD1	1.29e-03	15	67	2	IPR001192
Domain	PLC_EF-hand-like	PLCB4 PLCD1	1.29e-03	15	67	2	IPR015359
Domain	PI-PLC-Y	PLCB4 PLCD1	1.29e-03	15	67	2	PF00387
Domain	PLCYc	PLCB4 PLCD1	1.29e-03	15	67	2	SM00149
Domain	PI-PLC-X	PLCB4 PLCD1	1.87e-03	18	67	2	PF00388
Domain	PLCXc	PLCB4 PLCD1	1.87e-03	18	67	2	SM00148
Domain	PIPLC_X_DOMAIN	PLCB4 PLCD1	2.08e-03	19	67	2	PS50007
Domain	PLipase_C_PInositol-sp_X_dom	PLCB4 PLCD1	2.08e-03	19	67	2	IPR000909
Domain	PRAME_family	PRAMEF5 PRAMEF6	2.08e-03	19	67	2	IPR026271
Domain	UCH	USP17L4 USP17L1 USP17L3	2.12e-03	71	67	3	PF00443
Domain	USP_2	USP17L4 USP17L1 USP17L3	2.12e-03	71	67	3	PS00973
Domain	USP_3	USP17L4 USP17L1 USP17L3	2.21e-03	72	67	3	PS50235
Domain	USP_dom	USP17L4 USP17L1 USP17L3	2.21e-03	72	67	3	IPR028889
Domain	Peptidase_C19_UCH	USP17L4 USP17L1 USP17L3	2.21e-03	72	67	3	IPR001394
Domain	-	FRMD6 FGD2 KIF1A PLCB4 PLCD1 PLD2	2.76e-03	391	67	6	2.30.29.30
Domain	-	PLCB4 PLCD1	3.61e-03	25	67	2	3.20.20.190
Domain	PLC-like_Pdiesterase_TIM-brl	PLCB4 PLCD1	3.61e-03	25	67	2	IPR017946
Domain	Cys-rich_flank_reg_C	LRIG1 SLITRK3 CPN2	4.15e-03	90	67	3	IPR000483
Domain	LRRCT	LRIG1 SLITRK3 CPN2	4.15e-03	90	67	3	SM00082
Domain	PH_dom-like	FRMD6 FGD2 KIF1A PLCB4 PLCD1 PLD2	4.20e-03	426	67	6	IPR011993
Domain	LRRNT	LRIG1 SLITRK3 CPN2	5.26e-03	98	67	3	IPR000372
Domain	LRRNT	LRIG1 SLITRK3 CPN2	5.26e-03	98	67	3	SM00013
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	USP17L4 PRAMEF5 USP17L1 USP17L3 PRAMEF6	5.64e-08	50	70	5	31806660
Pubmed	High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency.	USP17L4 USP17L1 USP17L3	9.28e-07	10	70	3	24207026
Pubmed	Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells.	USP17L4 USP17L1 USP17L3	1.70e-06	12	70	3	24695638
Pubmed	ES cell neural differentiation reveals a substantial number of novel ESTs.	USP17L4 USP17L1 USP17L3	2.80e-06	14	70	3	11793228
Pubmed	Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a phospholipase D2 pathway.	ABCA1 PLD2	3.99e-06	2	70	2	16118212
Pubmed	The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2.	PLD2 ITGAL	3.99e-06	2	70	2	17486117
Pubmed	CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1.	USP17L4 USP17L1 USP17L3	7.39e-06	19	70	3	28067227
Pubmed	DUB-1, a deubiquitinating enzyme with growth-suppressing activity.	USP17L4 USP17L1 USP17L3	1.01e-05	21	70	3	8622927
Pubmed	DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.	USP17L4 USP17L1 USP17L3	1.01e-05	21	70	3	14583620
Pubmed	DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.	USP17L4 USP17L1 USP17L3	1.01e-05	21	70	3	11468161
Pubmed	The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.	USP17L4 USP17L1 USP17L3	1.01e-05	21	70	3	8756639
Pubmed	Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.	USP17L4 USP17L1 USP17L3	1.01e-05	21	70	3	12447969
Pubmed	DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.	USP17L4 USP17L1 USP17L3	1.01e-05	21	70	3	18980247
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF5 PRAMEF26 PRAMEF6	1.17e-05	22	70	3	31729367
Pubmed	JAK2 is required for induction of the murine DUB-1 gene.	USP17L4 USP17L1 USP17L3	1.17e-05	22	70	3	9154835
Pubmed	DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.	USP17L4 USP17L1 USP17L3	1.53e-05	24	70	3	8995226
Pubmed	Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.	USP17L4 USP17L1 USP17L3	1.74e-05	25	70	3	21115691
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF5 PRAMEF26 PRAMEF6	1.74e-05	25	70	3	37451217
Pubmed	Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.	USP17L4 USP17L1 USP17L3	1.96e-05	26	70	3	35816173
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF5 PRAMEF26 PRAMEF6	2.47e-05	28	70	3	25089626
Pubmed	Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.	USP17L4 USP17L1 USP17L3	2.75e-05	29	70	3	32527007
Pubmed	Cdc25A and Dub3 in a high-stakes balancing act.	USP17L4 USP17L1 USP17L3	4.08e-05	33	70	3	20228807
Pubmed	The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.	USP17L4 USP17L1 USP17L3	4.47e-05	34	70	3	20403174
Pubmed	Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.	USP17L4 USP17L1 USP17L3	4.47e-05	34	70	3	17109758
Pubmed	The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.	USP17L4 USP17L1 USP17L3	4.47e-05	34	70	3	20388806
Pubmed	DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.	USP17L4 USP17L1 USP17L3	4.47e-05	34	70	3	14699124
Pubmed	Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.	USP17L4 USP17L1 USP17L3	4.47e-05	34	70	3	20715989
Pubmed	Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.	USP17L4 USP17L1 USP17L3	4.47e-05	34	70	3	9806828
Pubmed	The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.	USP17L4 USP17L1 USP17L3	4.47e-05	34	70	3	20368735
Pubmed	The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.	USP17L4 USP17L1 USP17L3	4.47e-05	34	70	3	15780755
Pubmed	USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.	USP17L4 USP17L1 USP17L3	4.47e-05	34	70	3	19188362
Pubmed	Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.	USP17L4 USP17L1 USP17L3	4.47e-05	34	70	3	11941478
Pubmed	The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.	USP17L4 USP17L1 USP17L3	4.47e-05	34	70	3	10936051
Pubmed	The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.	USP17L4 USP17L1 USP17L3	4.47e-05	34	70	3	21448158
Pubmed	Cytokine-regulated protein degradation by the ubiquitination system.	USP17L4 USP17L1 USP17L3	4.88e-05	35	70	3	16611142
Pubmed	Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.	USP17L4 USP17L1 USP17L3	4.88e-05	35	70	3	21239494
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF5 PRAMEF26 PRAMEF6	4.88e-05	35	70	3	19389355
Pubmed	The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.	USP17L4 USP17L1 USP17L3	5.32e-05	36	70	3	20147298
Pubmed	Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.	USP17L4 USP17L1 USP17L3	5.78e-05	37	70	3	20228808
Pubmed	Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant.	NDST3 INTU	8.33e-05	7	70	2	21948523
Pubmed	Clmp Regulates AMPA and Kainate Receptor Responses in the Neonatal Hippocampal CA3 and Kainate Seizure Susceptibility in Mice.	SLC17A7 CLMP	1.11e-04	8	70	2	33408624
Pubmed	DNA sequence and analysis of human chromosome 8.	USP17L4 USP17L1 USP17L3	1.27e-04	48	70	3	16421571
Pubmed	Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line.	PLCB4 PLCD1	1.42e-04	9	70	2	7589147
Pubmed	Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat.	PLCB4 PLCD1	1.42e-04	9	70	2	10501179
Pubmed	Expression of phospholipase C isozymes by murine B lymphocytes.	PLCB4 PLCD1	1.78e-04	10	70	2	2033248
Pubmed	Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain.	SLC17A7 PLCB4	1.78e-04	10	70	2	15579147
Pubmed	Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function.	KIF1A TTLL7	2.17e-04	11	70	2	17360631
Pubmed	Kinase signalling in excitatory neurons regulates sleep quantity and depth.	SLC17A7 SIK3	2.60e-04	12	70	2	36477539
Pubmed	Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.	FZD9 PLCB4 PLCD1	3.41e-04	67	70	3	20398908
Pubmed	Mutation specific functions of EGFR result in a mutation-specific downstream pathway activation.	DNAJC16 EIF2B4 UBASH3B	3.56e-04	68	70	3	25754235
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	USP17L4 ABCA1 PRAMEF5 USP17L1 USP17L3 SLC35G6 PRAMEF6	4.14e-04	674	70	7	37196079
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF5 PRAMEF6	5.33e-04	17	70	2	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF5 PRAMEF6	5.33e-04	17	70	2	37781892
Pubmed	Human and mouse proteases: a comparative genomic approach.	USP17L4 USP17L1 USP17L3	5.95e-04	81	70	3	12838346
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF5 PRAMEF6	5.98e-04	18	70	2	23894331
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF5 PRAMEF6	5.98e-04	18	70	2	12890732
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF5 PRAMEF6	5.98e-04	18	70	2	29731491
Pubmed	Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.	PLCB4 PLCD1	5.98e-04	18	70	2	1979339
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF5 PRAMEF6	5.98e-04	18	70	2	14675769
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF5 PRAMEF6	5.98e-04	18	70	2	39181896
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF5 PRAMEF6	6.68e-04	19	70	2	28604677
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF5 PRAMEF6	7.41e-04	20	70	2	26694250
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF5 PRAMEF6	7.41e-04	20	70	2	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF5 PRAMEF6	7.41e-04	20	70	2	21425410
Pubmed	Specification of SUMO1- and SUMO2-interacting motifs.	PIAS4 SETX	8.99e-04	22	70	2	16524884
Pubmed	Slitrk4 is required for the development of inhibitory neurons in the fear memory circuit of the lateral amygdala.	SLC17A7 SLITRK3	8.99e-04	22	70	2	38736483
Pubmed	HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.	PLCB4 PLCD1	9.83e-04	23	70	2	9730685
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF5 PRAMEF6	9.83e-04	23	70	2	19480014
Pubmed	The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases.	PLCB4 PLCD1	9.83e-04	23	70	2	9278385
Pubmed	Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.	PLCB4 PLCD1	1.07e-03	24	70	2	10843712
Pubmed	Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes.	CUL2 GINS2	1.07e-03	24	70	2	34195792
Pubmed	The DNA sequence and biological annotation of human chromosome 1.	PRAMEF5 AGO1 LMX1A DNAJC16 OR2M3 USH2A PRAMEF6 TTLL7	1.08e-03	1031	70	8	16710414
Pubmed	Multiple developmental programs are altered by loss of Zic1 and Zic4 to cause Dandy-Walker malformation cerebellar pathogenesis.	LMX1A PLCB4	1.16e-03	25	70	2	21307096
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF5 PRAMEF6	1.16e-03	25	70	2	12620990
Pubmed	Dystroglycan Maintains Inner Limiting Membrane Integrity to Coordinate Retinal Development.	DAG1 SLC17A7	1.16e-03	25	70	2	28760865
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF5 PRAMEF6	1.26e-03	26	70	2	18500982
Pubmed	Mechanism of HIV-1-TAT induction of interleukin-1beta from human monocytes: Involvement of the phospholipase C/protein kinase C signaling cascade.	PLCB4 PLCD1	1.36e-03	27	70	2	20336759
Pubmed	Roof Plate-Derived Radial Glial-like Cells Support Developmental Growth of Rapidly Adapting Mechanoreceptor Ascending Axons.	LMX1A SLC17A7	1.57e-03	29	70	2	29874580
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	ABCA1 SETX KIF1A MUC16 SLITRK3	1.59e-03	420	70	5	28065597
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF5 PRAMEF6	1.67e-03	30	70	2	38786026
Pubmed	PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.	FZD9 SLC17A7 SLITRK3	1.72e-03	117	70	3	17145500
Pubmed	Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells.	ABCA1 LMX1A	1.79e-03	31	70	2	19796621
Pubmed	LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.	PRAMEF5 PRAMEF6	1.90e-03	32	70	2	37889087
Cytoband	1p36.21	PRAMEF5 PRAMEF26 PRAMEF6	1.26e-04	63	70	3	1p36.21
Cytoband	10q24	PDE6C EXOSC1	1.32e-03	35	70	2	10q24
Cytoband	11q24.1	CLMP UBASH3B	1.47e-03	37	70	2	11q24.1
Cytoband	8p23.1	USP17L4 USP17L1 USP17L3	1.72e-03	154	70	3	8p23.1
GeneFamily	PRAME family	PRAMEF5 PRAMEF26 PRAMEF6	4.61e-05	24	53	3	686
GeneFamily	Phospholipases	PLCB4 PLCD1 PLD2	2.52e-04	42	53	3	467
GeneFamily	Phospholipases\|C2 domain containing phospholipases	PLCB4 PLCD1	1.40e-03	19	53	2	832
Computational	Neighborhood of PAX7	ABCA1 FIG4 NPFF DNAJC16 SLC17A7 LTBP4	1.63e-04	266	34	6	MORF_PAX7
Computational	Neighborhood of STK17A	ABCA1 FIG4 NPFF DNAJC16 LTBP4	1.89e-04	172	34	5	MORF_STK17A
Disease	primary ovarian insufficiency (implicated_via_orthology)	USP17L4 USP17L1 USP17L3	1.38e-04	46	64	3	DOID:5426 (implicated_via_orthology)
Disease	Charcot-Marie-Tooth Disease	SETX FIG4	3.01e-04	12	64	2	C0007959
Disease	Hereditary Motor and Sensory-Neuropathy Type II	KIF1A FIG4	3.56e-04	13	64	2	C0270914
Disease	congenital heart disease (implicated_via_orthology)	USP17L4 USP17L1 USP17L3	4.60e-04	69	64	3	DOID:1682 (implicated_via_orthology)
Disease	pentachlorophenol measurement	DNER MUC16 USH2A	5.43e-04	73	64	3	EFO_0022071
Disease	parathion measurement	DNER MUC16 USH2A	5.43e-04	73	64	3	EFO_0022070
Disease	potassium chromate measurement	DNER MUC16 USH2A	5.43e-04	73	64	3	EFO_0022072
Disease	mercuric chloride measurement	DNER MUC16 USH2A	5.43e-04	73	64	3	EFO_0022068
Disease	heptachlor epoxide measurement	DNER MUC16 USH2A	5.43e-04	73	64	3	EFO_0022067
Disease	methoxychlor measurement	DNER MUC16 USH2A	5.43e-04	73	64	3	EFO_0022069
Disease	4,6-dinitro-o-cresol measurement	DNER MUC16 USH2A	5.43e-04	73	64	3	EFO_0022053
Disease	2,4,5-trichlorophenol measurement	DNER MUC16 USH2A	5.43e-04	73	64	3	EFO_0022052
Disease	azinphos methyl measurement	DNER MUC16 USH2A	5.43e-04	73	64	3	EFO_0022055
Disease	aldrin measurement	DNER MUC16 USH2A	5.43e-04	73	64	3	EFO_0022054
Disease	dicofol measurement	DNER MUC16 USH2A	5.43e-04	73	64	3	EFO_0022060
Disease	disulfoton measurement	DNER MUC16 USH2A	5.43e-04	73	64	3	EFO_0022062
Disease	dieldrin measurement	DNER MUC16 USH2A	5.43e-04	73	64	3	EFO_0022061
Disease	endrin measurement	DNER MUC16 USH2A	5.43e-04	73	64	3	EFO_0022064
Disease	endosulfan measurement	DNER MUC16 USH2A	5.43e-04	73	64	3	EFO_0022063
Disease	heptachlor measurement	DNER MUC16 USH2A	5.43e-04	73	64	3	EFO_0022066
Disease	ethion measurement	DNER MUC16 USH2A	5.43e-04	73	64	3	EFO_0022065
Disease	chlorpyrifos measurement	DNER MUC16 USH2A	5.43e-04	73	64	3	EFO_0022057
Disease	cadmium chloride measurement	DNER MUC16 USH2A	5.43e-04	73	64	3	EFO_0022056
Disease	diazinon measurement	DNER MUC16 USH2A	5.43e-04	73	64	3	EFO_0022059
Disease	dibutyl phthalate measurement	DNER MUC16 USH2A	5.43e-04	73	64	3	EFO_0022058
Disease	environmental exposure measurement	DNER MUC16 USH2A	5.43e-04	73	64	3	EFO_0008360
Disease	DDT metabolite measurement	DNER MUC16 USH2A	5.65e-04	74	64	3	EFO_0007886
Disease	Amyotrophic lateral sclerosis	SETX FIG4	6.17e-04	17	64	2	cv:C0002736
Disease	protein C measurement	FZD9 FRMD6	6.17e-04	17	64	2	EFO_0004633
Disease	dilated cardiomyopathy (implicated_via_orthology)	DNER EXOSC1 DAG1	7.10e-04	80	64	3	DOID:12930 (implicated_via_orthology)
Disease	Charcot-Marie-Tooth disease (implicated_via_orthology)	FGD2 FIG4	1.24e-03	24	64	2	DOID:10595 (implicated_via_orthology)
Disease	hearing impairment	TMC1 LMX1A USH2A	1.28e-03	98	64	3	C1384666
Disease	blood cobalt measurement	DNER MUC16 USH2A	1.39e-03	101	64	3	EFO_0007577
Disease	Autosomal dominant nonsyndromic hearing loss	TMC1 LMX1A	1.81e-03	29	64	2	cv:C5779548

Protein segments in the cluster

Peptide	Gene	Start	Entry
RSLMLSYNAITHLPA	CPN2	316	P22792
PLHTLRNLMYLVSPS	ATG14	371	Q6ZNE5
SRPYMASLQRNGSHL	GZMM	36	P51124
KHRNMLQYQLPSSLS	ABCA1	2171	O95477
PMFRHLKNTYSGLQL	AGO1	501	Q9UL18
YPTAISGLQSQRMRH	CACNB4	426	O00305
LNPISIFMTHLSNYG	NDST3	511	O95803
MQHLLSPLFQRSSLG	MUC16	13956	Q8WXI7
SDSQLHTPMYFLLRN	OR4D2	51	P58180
LNTRLHTPMYFLLSQ	OR2AK2	66	Q8NG84
CQGSLYPSNHDRMLT	LRIG1	991	Q96JA1
LQTNHVTMLLRNPYL	NEMF	401	O60524
ENTHNGLRMSIYPKS	MEPE	106	Q9NQ76
RLYPDMLQSSSQLSH	KCNH7	246	Q9NS40
TPLGNRYMALIQHST	IL17RB	201	Q9NRM6
SNSQLMYGLPDSSHV	DAG1	556	Q14118
AYPMKSSHLRLSQGN	FSIP2	2791	Q5CZC0
LQSRVGNPIDHLYSM	LMX1A	361	Q8TE12
LDTQLHTPMYLLLSQ	OR2M3	51	Q8NG83
TLHGQETYTPRLILM	MSTO1	56	Q9BUK6
NLYQMKSTSPLARLH	PDE6C	611	P51160
YTSNLVRLRPGHMNV	DNAJC16	611	Q9Y2G8
RANLHMNLYETSPLT	KIAA2012	651	Q0VF49
HILYVGSMPLKNSFR	EXOSC1	86	Q9Y3B2
AMLRLQLYGYHSPTN	MICU3	281	Q86XE3
SVIHPAMVRLGLQYS	EIF2B4	201	Q9UI10
QDMGQPLSHYLVSSS	PLCD1	296	P51178
SGLNTPHIIMYLTLQ	INTU	301	Q9ULD6
LFMYLQPRSNHSLDT	OR8J2	256	Q8NGG1
GYNLTRMPNLLGHTS	FZD9	51	O00144
LLSNSHRLYMNLQPV	FRMD6	316	Q96NE9
KSLPGYMTRHNNLDL	IDH3B	146	O43837
LSHSLQYNLTVLRMP	FIG4	171	Q92562
NMYVLLRAVSTGLPH	CUL2	296	Q13617
LSHLTSMYLNAPALA	MAN2A2	1011	P49641
GLTRSVYTMPLANHR	LTBP4	196	Q8N2S1
MRAHTSIPLLGYQVT	FGD2	586	Q7Z6J4
LTNMPRHSLYIIIGA	DNER	631	Q8NFT8
SRVTVNQMLLHPYSR	ERVFC1	551	P60507
ILTQFTPYLGHMRNL	PRAMEF26	126	H0Y7S4
AYLQLPSTMTNLRSG	NEURL4	591	Q96JN8
SSMHNSLLLNRVTPY	KIF1A	1246	Q12756
SPRYQLQMRSGDSTH	USH2A	2466	O75445
GATTNIHPYLSTMIN	PLCB4	556	Q15147
ILLIRTNSHLQTPMY	OR5M1	46	Q8NGP8
HMYKLRTNLQPLEST	GINS2	166	Q9Y248
LTPGMFRGLQSLHYL	SLITRK3	471	O94933
LSLHSMPSNSVQLAY	SETX	521	Q7Z333
HRTNLMATLSYGHRP	SIK3	846	Q9Y2K2
MATLSYGHRPLSKQL	SIK3	851	Q9Y2K2
TLNMLIPSAARVHYG	SLC17A7	156	Q9P2U7
KTSLLASGAPRYQHM	ITGAL	416	P20701
AQTSGSLLHYLLQAM	NPFF	46	O15130
SLPGINILRLHTSMY	TMC1	596	Q8TDI8
GRVLLQNLTMSYSGL	CLMP	191	Q9H6B4
MRYLTSHLTPRQAQA	TEX44	376	Q53QW1
LTQFTPYLGHMRNLQ	PRAMEF6	221	Q5VXH4
TLPLANYMLSREHSQ	USP17L3	101	A6NCW0
TLPLANYMLSREHSQ	USP17L4	101	A6NCW7
LVHSYMTGRRPLSQA	SH2D3A	91	Q9BRG2
LTQFTPYLGHMRNLQ	PRAMEF5	221	Q5TYX0
TLPLANYMLSREHSQ	USP17L1	101	Q7RTZ2
PLSHMAYQASNLPSL	SLC35G6	56	P0C7Q6
RPINLTHLMYLSSAT	PIAS4	241	Q8N2W9
LSSILNHGRLSPQYM	TTC7A	106	Q9ULT0
KGRYIRTNLNMPHSL	UBASH3B	411	Q8TF42
SMLNAYSNLSLSGPR	ZC3H12C	591	Q9C0D7
INSGYSKRALMLLHP	PLD2	411	O14939
LGHFLTPMRLAQLYS	TRPM4	451	Q8TD43
LNRASSYMRHLPHSN	TTLL7	641	Q6ZT98
NRTLRLLMSQYGHFP	KEL	191	P23276