Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionepidermal growth factor receptor activity

ERBB4 EGFR

9.94e-054822GO:0005006
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase activity

ERBB2 ERBB4 CRIM1 EGFR

1.48e-0465824GO:0004714
GeneOntologyMolecularFunctionneuregulin binding

ERBB4 ITGA6

2.47e-046822GO:0038132
GeneOntologyMolecularFunctiontransmembrane receptor protein kinase activity

ERBB2 ERBB4 CRIM1 EGFR

4.15e-0485824GO:0019199
GeneOntologyMolecularFunctiongrowth factor binding

ERBB2 ERBB4 EGFR ITGA6 LTBP2

4.59e-04156825GO:0019838
GeneOntologyCellularComponentbasal part of cell

SLC6A13 ERBB2 ERBB4 SLC2A9 EGFR PKD1 ITGA6 MARK2 ABCC6 CASK

1.99e-063788110GO:0045178
GeneOntologyCellularComponentbasolateral plasma membrane

SLC6A13 ERBB2 ERBB4 SLC2A9 EGFR PKD1 ITGA6 ABCC6 CASK

4.09e-06320819GO:0016323
GeneOntologyCellularComponentbasal plasma membrane

SLC6A13 ERBB2 ERBB4 SLC2A9 EGFR PKD1 ITGA6 ABCC6 CASK

9.24e-06354819GO:0009925
GeneOntologyCellularComponentcell projection membrane

ERBB2 SLC9A5 EGFR PACSIN1 PKD1 CDHR5 CNGA2 CASK

2.64e-04431818GO:0031253
GeneOntologyCellularComponentneuromuscular junction

ERBB2 ERBB4 LAMA2 CAV3

9.46e-04112814GO:0031594
GeneOntologyCellularComponentGolgi-associated vesicle

PACSIN1 PKD1 BACE1 CNGA2

1.01e-03114814GO:0005798
DomainTyr_kinase_EGF/ERB/XmrK_rcpt

ERBB2 ERBB4 EGFR

3.13e-074813IPR016245
DomainGF_recep_IV

ERBB2 ERBB4 EGFR

1.56e-066813PF14843
DomainGF_recep_IV

ERBB2 ERBB4 EGFR

1.56e-066813IPR032778
DomainFurin-like

ERBB2 ERBB4 EGFR

2.72e-067813PF00757
DomainRcpt_L-dom

ERBB2 ERBB4 EGFR

2.72e-067813IPR000494
DomainFurin-like_Cys-rich_dom

ERBB2 ERBB4 EGFR

2.72e-067813IPR006211
DomainRecep_L_domain

ERBB2 ERBB4 EGFR

2.72e-067813PF01030
Domain-

ERBB2 ERBB4 EGFR

2.72e-0678133.80.20.20
DomainTECPR

HERC2 TECPR1

5.56e-053812SM00706
DomainBeta-propeller_rpt_TECPR

HERC2 TECPR1

5.56e-053812IPR006624
DomainGrowth_fac_rcpt_

CD93 ERBB2 ERBB4 CRIM1 EGFR LTBP2

5.97e-05156816IPR009030
DomainFurin_repeat

ERBB2 ERBB4 EGFR

6.12e-0518813IPR006212
DomainFU

ERBB2 ERBB4 EGFR

6.12e-0518813SM00261
Domain-

RCC1L HERC2 TECPR1

1.14e-04228132.130.10.30
DomainRCC1/BLIP-II

RCC1L HERC2 TECPR1

1.31e-0423813IPR009091
DomainMit_uncoupling

SLC25A14 SLC25A30

1.19e-0312812IPR002030
DomainCRYSTALLIN_BETA_GAMMA

CRYGS CRYBG1

1.88e-0315812PS50915
DomainCrystall

CRYGS CRYBG1

1.88e-0315812PF00030
DomainBeta/gamma_crystallin

CRYGS CRYBG1

1.88e-0315812IPR001064
DomainXTALbg

CRYGS CRYBG1

1.88e-0315812SM00247
DomainG_crystallin-rel

CRYGS CRYBG1

2.72e-0318812IPR011024
DomainZZ

TADA2B HERC2

2.72e-0318812PF00569
DomainNA_NEUROTRAN_SYMP_2

SLC6A13 SLC6A16

2.72e-0318812PS00754
DomainZF_ZZ_2

TADA2B HERC2

2.72e-0318812PS50135
DomainZF_ZZ_1

TADA2B HERC2

2.72e-0318812PS01357
DomainL_dom-like

ERBB2 ERBB4 CMIP EGFR PKD1 LMOD2

3.01e-03328816IPR032675
DomainZnf_ZZ

TADA2B HERC2

3.03e-0319812IPR000433
DomainSNF

SLC6A13 SLC6A16

3.03e-0319812PF00209
DomainNA_NEUROTRAN_SYMP_1

SLC6A13 SLC6A16

3.03e-0319812PS00610
DomainNA_NEUROTRAN_SYMP_3

SLC6A13 SLC6A16

3.03e-0319812PS50267
DomainZnF_ZZ

TADA2B HERC2

3.03e-0319812SM00291
DomainNa/ntran_symport

SLC6A13 SLC6A16

3.03e-0319812IPR000175
DomainRCC1

RCC1L HERC2

3.36e-0320812PF00415
DomainRCC1_1

RCC1L HERC2

3.70e-0321812PS00625
DomainRCC1_2

RCC1L HERC2

3.70e-0321812PS00626
DomainRCC1_3

RCC1L HERC2

3.70e-0321812PS50012
Domain-

GLB1L LAMA2 HERC2

3.93e-03738132.60.120.260
DomainReg_chr_condens

RCC1L HERC2

4.06e-0322812IPR000408
Domainfn3

ROBO4 CNTN5 IGSF9 CDON

5.41e-03162814PF00041
PathwayREACTOME_ERBB2_ACTIVATES_PTK6_SIGNALING

ERBB2 ERBB4 EGFR

8.58e-0611543MM15478
PathwayREACTOME_ERBB2_ACTIVATES_PTK6_SIGNALING

ERBB2 ERBB4 EGFR

1.48e-0513543M27729
PathwayREACTOME_ERBB2_REGULATES_CELL_MOTILITY

ERBB2 ERBB4 EGFR

1.48e-0513543MM15320
PathwayREACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING

ERBB2 ERBB4 EGFR

1.88e-0514543MM14761
PathwayREACTOME_SHC1_EVENTS_IN_ERBB2_SIGNALING

ERBB2 ERBB4 EGFR

1.88e-0514543MM14531
PathwayPID_ERBB_NETWORK_PATHWAY

ERBB2 ERBB4 EGFR

2.34e-0515543M201
PathwayREACTOME_ERBB2_REGULATES_CELL_MOTILITY

ERBB2 ERBB4 EGFR

2.34e-0515543M27608
PathwayPID_A6B1_A6B4_INTEGRIN_PATHWAY

ERBB2 EGFR LAMA2 ITGA6

2.78e-0546544M239
PathwayREACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING

ERBB2 ERBB4 EGFR

2.87e-0516543M562
PathwayREACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING

ERBB2 ERBB4 EGFR

2.87e-0516543M570
PathwayREACTOME_SHC1_EVENTS_IN_ERBB2_SIGNALING

ERBB2 ERBB4 EGFR

7.77e-0522543M26929
PathwayBIOCARTA_HER2_PATHWAY

ERBB2 ERBB4 EGFR

8.91e-0523543MM1480
PathwayBIOCARTA_HER2_PATHWAY

ERBB2 ERBB4 EGFR

8.91e-0523543M18719
PathwayWP_FOCAL_ADHESION

ERBB2 EGFR LAMA2 ITGA6 PRKCG CAV3

1.08e-04199546M39402
PathwayKEGG_FOCAL_ADHESION

ERBB2 EGFR LAMA2 ITGA6 PRKCG CAV3

1.08e-04199546M7253
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_UBIQUITINATION_OF_RTK_BY_CBL

ERBB2 ERBB4 EGFR

1.15e-0425543M47934
PathwayWP_ALPHA_6_BETA_4_INTEGRIN_SIGNALING_PATHWAY

ERBB2 EGFR LAMA2 ITGA6

1.16e-0466544MM15925
PathwayREACTOME_SIGNALING_BY_ERBB2_IN_CANCER

ERBB2 ERBB4 EGFR

1.30e-0426543M29535
PathwayREACTOME_DOWNREGULATION_OF_ERBB2_SIGNALING

ERBB2 ERBB4 EGFR

1.30e-0426543MM15501
PathwayREACTOME_DOWNREGULATION_OF_ERBB2_SIGNALING

ERBB2 ERBB4 EGFR

1.81e-0429543M27756
PathwayWP_MAMMARY_GLAND_DEVELOPMENT_PREGNANCY_AND_LACTATION_STAGE_3_OF_4

ERBB2 ERBB4 EGFR

2.67e-0433543M39455
PathwayKEGG_MEDICUS_VARIANT_ERBB2_OVEREXPRESSION_TO_EGF_JAK_STAT_SIGNALING_PATHWAY

ERBB2 EGFR

2.99e-047542M47431
PathwayKEGG_ERBB_SIGNALING_PATHWAY

ERBB2 ERBB4 EGFR PRKCG

3.38e-0487544M12467
PathwayBIOCARTA_KREB_PATHWAY

ACO2 IDH2

3.97e-048542M6831
PathwayKEGG_MEDICUS_REFERENCE_TGFA_EGFR_PLCG_PKC_SIGNALING_PATHWAY

EGFR PRKCG

3.97e-048542M47479
PathwayWP_ERBB_SIGNALING

ERBB2 ERBB4 EGFR PRKCG

4.19e-0492544M39715
PathwayKEGG_MEDICUS_REFERENCE_CITRATE_CYCLE_FIRST_CARBON_OXIDATION

ACO2 IDH2

5.10e-049542M47937
PathwayREACTOME_SIGNALING_BY_ERBB2

ERBB2 ERBB4 EGFR

6.30e-0444543MM14520
PathwayWP_ERBB_SIGNALING_PATHWAY

ERBB2 ERBB4 EGFR

7.18e-0446543MM15950
PathwayWP_FOCAL_ADHESION

ERBB2 EGFR LAMA2 ITGA6 CAV3

7.27e-04187545MM15913
PathwayPID_INTEGRIN4_PATHWAY

LAMA2 ITGA6

7.75e-0411542M158
PathwayREACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING

ERBB2 ERBB4

7.75e-0411542MM14760
PathwayREACTOME_SIGNALING_BY_PTK6

ERBB2 ERBB4 EGFR

8.14e-0448543MM15479
PathwayREACTOME_SIGNALING_BY_ERBB2

ERBB2 ERBB4 EGFR

9.17e-0450543M553
PathwayKEGG_MEDICUS_VARIANT_ERBB2_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY

ERBB2 EGFR

9.27e-0412542M47393
PathwayREACTOME_SIGNALING_BY_PTK6

ERBB2 ERBB4 EGFR

1.15e-0354543M29742
PathwayKEGG_NON_SMALL_CELL_LUNG_CANCER

ERBB2 EGFR PRKCG

1.15e-0354543M19818
PathwayKEGG_MEDICUS_REFERENCE_RTK_PLCG_ITPR_SIGNALING_PATHWAY

ERBB2 ERBB4 EGFR

1.21e-0355543M47952
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PLCG_ERK_SIGNALING_PATHWAY

EGFR PRKCG

1.27e-0314542M47383
PathwayREACTOME_TFAP2_AP_2_FAMILY_REGULATES_TRANSCRIPTION_OF_GROWTH_FACTORS_AND_THEIR_RECEPTORS

ERBB2 EGFR

1.46e-0315542M27766
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_ERK_SIGNALING_PATHWAY

EGFR PRKCG

1.46e-0315542M47382
PathwayREACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS

LAMA2 ITGA6 CASK

1.48e-0359543M27218
PathwayKEGG_MEDICUS_REFERENCE_EGF_ERBB2_RAS_ERK_SIGNALING_PATHWAY

ERBB2 EGFR

1.67e-0316542M47381
PathwayREACTOME_SIGNALING_BY_ERBB2_ECD_MUTANTS

ERBB2 EGFR

1.67e-0316542M29847
PathwayPID_SYNDECAN_3_PATHWAY

EGFR CASK

1.89e-0317542M251
PathwayWP_PHYSICOCHEMICAL_FEATURES_AND_TOXICITYASSOCIATED_PATHWAYS

ERBB2 ERBB4 EGFR

2.05e-0366543M39642
PathwayWP_INTERACTIONS_BETWEEN_LOXL4_AND_OXIDATIVE_STRESS_PATHWAY

PKD1 LOXL4

2.12e-0318542M39586
PathwayWP_MAMMARY_GLAND_DEVELOPMENT_EMBRYONIC_DEVELOPMENT_STAGE_1_OF_4

ERBB4 ITGA6

2.12e-0318542M39327
PathwayREACTOME_MATURATION_OF_TCA_ENZYMES_AND_REGULATION_OF_TCA_CYCLE

ACO2 IDH2

2.12e-0318542MM17239
PathwayWP_TCA_CYCLE_AKA_KREBS_OR_CITRIC_ACID_CYCLE

ACO2 IDH2

2.12e-0318542M39460
PathwayREACTOME_MATURATION_OF_TCA_ENZYMES_AND_REGULATION_OF_TCA_CYCLE

ACO2 IDH2

2.62e-0320542M48266
PathwayREACTOME_VXPX_CARGO_TARGETING_TO_CILIUM

PKD1 CNGA2

2.62e-0320542MM15208
PathwayWP_NONSMALL_CELL_LUNG_CANCER

ERBB2 EGFR PRKCG

2.63e-0372543M39738
PathwayREACTOME_VXPX_CARGO_TARGETING_TO_CILIUM

PKD1 CNGA2

2.89e-0321542M27479
Pubmed

Spontaneous activation and signaling by overexpressed epidermal growth factor receptors in glioblastoma cells.

ERBB2 ERBB4 EGFR

1.26e-08382312532415
Pubmed

Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype.

ERBB2 EGFR ITGA6

1.26e-0838237618084
Pubmed

ErbB receptors protect the perfused heart against injury induced by epinephrine combined with low-flow ischemia.

ERBB2 ERBB4 EGFR

1.26e-08382319370475
Pubmed

Absence of EGFR, ERBB2 and ERBB4 mutation homologous to the oncogenic ERBB3 Val-104 mutation in colorectal cancers.

ERBB2 ERBB4 EGFR

1.26e-08382324862237
Pubmed

Cell surface expression of epidermal growth factor receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcoma.

ERBB2 ERBB4 EGFR

1.26e-08382315026342
Pubmed

Association of ErbB1-4 expression in invasive breast cancer with clinicopathological characteristics and prognosis.

ERBB2 ERBB4 EGFR

1.26e-08382323100016
Pubmed

Kinase activator-receiver preference in ErbB heterodimers is determined by intracellular regions and is not coupled to extracellular asymmetry.

ERBB2 ERBB4 EGFR

1.26e-08382325468910
Pubmed

The relation between survival and expression of HER1 and HER2 depends on the expression of HER3 and HER4: a study in bladder cancer patients.

ERBB2 ERBB4 EGFR

5.04e-08482316685269
Pubmed

Characterisation of HER heterodimers in breast cancer using in situ proximity ligation assay.

ERBB2 ERBB4 EGFR

5.04e-08482324557338
Pubmed

Inverse regulation of EGFR/HER1 and HER2-4 in normal and malignant human breast tissue.

ERBB2 ERBB4 EGFR

5.04e-08482323991224
Pubmed

Expression of epidermal growth factors, erbBs, in the nasal mucosa of patients with chronic hypertrophic rhinitis.

ERBB2 ERBB4 EGFR

5.04e-08482322327010
Pubmed

Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain.

ERBB2 ERBB4 EGFR

5.04e-08482317177598
Pubmed

The relevance of EGFR, ErbB receptors and neuregulins in human adipocytes and adipose tissue in obesity.

ERBB2 ERBB4 EGFR

5.04e-08482336411648
Pubmed

HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer.

ERBB2 ERBB4 EGFR

5.04e-08482321203579
Pubmed

ErbB2 and ErbB4 Cbl binding sites can functionally replace the ErbB1 Cbl binding site.

ERBB2 ERBB4 EGFR

5.04e-08482319263517
Pubmed

The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases.

ERBB2 ERBB4 EGFR

5.04e-08482315345710
Pubmed

Analysis of ErbB receptors in pulmonary carcinoid tumors.

ERBB2 ERBB4 EGFR

5.04e-08482319447869
Pubmed

Evaluation of the prognostic and predictive value of HER family mRNA expression in high-risk early breast cancer: a Hellenic Cooperative Oncology Group (HeCOG) study.

ERBB2 ERBB4 EGFR

5.04e-08482318985033
Pubmed

Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function.

ERBB2 ERBB4 EGFR

5.04e-08482312621152
Pubmed

Activation of ErbB4 by the bifunctional epidermal growth factor family hormone epiregulin is regulated by ErbB2.

ERBB2 ERBB4 EGFR

5.04e-0848239556621
Pubmed

Activated HER-receptors in predicting outcome of ER-positive breast cancer patients treated with adjuvant endocrine therapy.

ERBB2 ERBB4 EGFR

5.04e-08482322854050
Pubmed

The erbB/HER type 1 tyrosine kinase receptor family.

ERBB2 ERBB4 EGFR

5.04e-0848239771475
Pubmed

Expression of the HER-1-4 family of receptor tyrosine kinases in neuroendocrine tumours.

ERBB2 ERBB4 EGFR

5.04e-08482320204273
Pubmed

Laminin-1 and epidermal growth factor family members co-stimulate fetal pancreas cell proliferation and colony formation.

ERBB2 ERBB4 EGFR

5.04e-08482315733067
Pubmed

WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus.

ERBB2 ERBB4 EGFR

5.04e-08482312807903
Pubmed

HER Family Protein Expression in a Greek Population with Gastric Cancer. A Retrospective Hellenic Cooperative Oncology Group Study.

ERBB2 ERBB4 EGFR

5.04e-08482327069134
Pubmed

A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor.

ERBB2 ERBB4 EGFR

5.04e-0848238816440
Pubmed

Evaluation of the prognostic significance of HER family mRNA expression in high-risk early breast cancer: a Hellenic Cooperative Oncology Group (HeCOG) validation study.

ERBB2 ERBB4 EGFR

5.04e-08482326021752
Pubmed

Tissue interaction mediated by neuregulin-1 and ErbB receptors regulates epithelial morphogenesis of mouse embryonic submandibular gland.

ERBB2 ERBB4 EGFR

1.26e-07582315254894
Pubmed

Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity.

ERBB2 ERBB4 EGFR

1.26e-07582310572067
Pubmed

Expression of epidermal growth factors and a tight junction protein in the nasal mucosa of patients with chronic hypertrophic rhinitis.

ERBB2 ERBB4 EGFR

1.26e-07582323137868
Pubmed

Gene expression pattern of the epidermal growth factor receptor family and LRIG1 in renal cell carcinoma.

ERBB2 ERBB4 EGFR

1.26e-07582322554477
Pubmed

Developmental profile of ErbB receptors in murine central nervous system: implications for functional interactions.

ERBB2 ERBB4 EGFR

1.26e-07582315682390
Pubmed

Neuregulin-1 induces branching morphogenesis in the developing lung through a P13K signal pathway.

ERBB2 ERBB4 EGFR

1.26e-07582315524405
Pubmed

Segregation of receptor and ligand regulates activation of epithelial growth factor receptor.

ERBB2 ERBB4 EGFR

1.26e-07582312646923
Pubmed

Hepatitis C Virus Activates a Neuregulin-Driven Circuit to Modify Surface Expression of Growth Factor Receptors of the ErbB Family.

ERBB2 ERBB4 EGFR

1.26e-07582326886748
Pubmed

Localization of phosphorylated ErbB1-4 and heregulin in colorectal cancer.

ERBB2 ERBB4 EGFR

1.26e-07582325416285
Pubmed

Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle.

ERBB2 ERBB4 EGFR

1.26e-0758237589796
Pubmed

Unraveling ERBB network dynamics upon betacellulin signaling in pancreatic ductal adenocarcinoma in mice.

ERBB2 ERBB4 EGFR

2.51e-07682332335999
Pubmed

The ectodomain of cadherin-11 binds to erbB2 and stimulates Akt phosphorylation to promote cranial neural crest cell migration.

ERBB2 ERBB4 EGFR

2.51e-07682329190819
Pubmed

LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation.

ERBB2 ERBB4 EGFR

2.51e-07682315282549
Pubmed

Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland.

ERBB2 ERBB4 EGFR

2.51e-07682311278868
Pubmed

Modulation of Erbb2 signaling during development: a threshold level of Erbb2 signaling is required for development.

ERBB2 ERBB4 EGFR

2.51e-07682315496447
Pubmed

Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4.

ERBB2 ERBB4 EGFR

4.39e-07782317487277
Pubmed

Neuregulin-1/ErbB4 signaling controls the migration of oligodendrocyte precursor cells during development.

ERBB2 ERBB4 EGFR

4.39e-07782322504067
Pubmed

A comprehensive study of the association between the EGFR and ERBB2 genes and glioma risk.

ERBB2 ERBB4 EGFR

4.39e-07782320446891
Pubmed

Stretch-induced fetal type II cell differentiation is mediated via ErbB1-ErbB4 interactions.

ERBB2 ERBB4 EGFR

4.39e-07782322493501
Pubmed

Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis.

ERBB2 ERBB4 EGFR

4.39e-07782320126551
Pubmed

Syndecan-1 and Syndecan-4 Capture Epidermal Growth Factor Receptor Family Members and the α3β1 Integrin Via Binding Sites in Their Ectodomains: NOVEL SYNSTATINS PREVENT KINASE CAPTURE AND INHIBIT α6β4-INTEGRIN-DEPENDENT EPITHELIAL CELL MOTILITY.

ERBB2 EGFR ITGA6

7.01e-07882326350464
Pubmed

Cytoplasmic domain interactions of syndecan-1 and syndecan-4 with α6β4 integrin mediate human epidermal growth factor receptor (HER1 and HER2)-dependent motility and survival.

ERBB2 EGFR ITGA6

7.01e-07882325202019
Pubmed

Dynamic expression of Erbb pathway members during early mammary gland morphogenesis.

ERBB2 ERBB4 EGFR

7.01e-07882317960183
Pubmed

Differential expression of neuregulins and their receptors in the olfactory bulb layers of the developing mouse.

ERBB2 ERBB4 EGFR

7.01e-07882316488402
Pubmed

Embryo-uterine interactions via the neuregulin family of growth factors during implantation in the mouse.

ERBB2 ERBB4 EGFR

7.01e-07882315306553
Pubmed

ERBB3-dependent AKT and ERK pathways are essential for atrioventricular cushion development in mouse embryos.

ERBB2 ERBB4 EGFR

1.05e-06982334714866
Pubmed

In situ hybridization reveals developmental regulation of ErbB1-4 mRNA expression in mouse midbrain: implication of ErbB receptors for dopaminergic neurons.

ERBB2 ERBB4 EGFR

1.50e-061082319298847
Pubmed

The epidermal growth factor receptor couples transforming growth factor-alpha, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4.

ERBB2 ERBB4 EGFR

1.50e-06108238702723
Pubmed

Somatic mutations in epidermal growth factor receptor signaling pathway genes in non-small cell lung cancers.

ERBB2 ERBB4 EGFR

1.50e-061082320881644
Pubmed

Evidence for new homotypic and heterotypic interactions between transmembrane helices of proteins involved in receptor tyrosine kinase and neuropilin signaling.

ERBB2 ERBB4 EGFR

2.06e-061182325315821
Pubmed

Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors.

ERBB2 ERBB4 EGFR

2.06e-061182310821760
Pubmed

Altered trophoblast proliferation is insufficient to account for placental dysfunction in Egfr null embryos.

ERBB2 ERBB4 EGFR

2.06e-061182317822758
Pubmed

An EGFR-ERK-SOX9 signaling cascade links urothelial development and regeneration to cancer.

ERBB2 ERBB4 EGFR

3.55e-061382321512138
Pubmed

Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of Pkd1.

ERBB2 EGFR PKD1

4.51e-061482316400024
Pubmed

Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system.

ERBB2 ERBB4 LAMA2

4.51e-061482319240213
Pubmed

Prognostic and predictive values of EGFR overexpression and EGFR copy number alteration in HER2-positive breast cancer.

ERBB2 EGFR

5.49e-06282225349977
Pubmed

Prognostic role of human epidermal growth factor receptor in gastric cancer: a systematic review and meta-analysis.

ERBB2 EGFR

5.49e-06282223871709
Pubmed

HER1 R497K and HER2 I655V polymorphisms are linked to development of breast cancer.

ERBB2 EGFR

5.49e-06282223594562
Pubmed

Identification of autophosphorylation sites of HER2/neu.

ERBB2 EGFR

5.49e-0628221706616
Pubmed

Effects of the combined blockade of EGFR and ErbB-2 on signal transduction and regulation of cell cycle regulatory proteins in breast cancer cells.

ERBB2 EGFR

5.49e-06282219946741
Pubmed

EGFR and ERBB2 Exon 20 Insertion Mutations in Chinese Non-small Cell Lung Cancer Patients: Pathological and Molecular Characterization, and First-Line Systemic Treatment Evaluation.

ERBB2 EGFR

5.49e-06282238416376
Pubmed

Evolutionary analysis of the ErbB receptor and ligand families.

ERBB2 EGFR

5.49e-06282210824084
Pubmed

Genetic and expression analysis of HER-2 and EGFR genes in salivary duct carcinoma: empirical and therapeutic significance.

ERBB2 EGFR

5.49e-06282220371674
Pubmed

Epidermal growth factor receptor status in breast cancer metastases to the central nervous system. Comparison with HER-2/neu status.

ERBB2 EGFR

5.49e-06282215335267
Pubmed

Significance of epidermal growth factor receptor expression in breast cancer.

ERBB2 EGFR

5.49e-06282221104342
Pubmed

ERF: genomic organization, chromosomal localization and promoter analysis of the human and mouse genes.

ERF PRKCG

5.49e-0628229136988
Pubmed

Her4 and Her2/neu tyrosine kinase domains dimerize and activate in a reconstituted in vitro system.

ERBB2 ERBB4

5.49e-06282220022944
Pubmed

Synergistic Blockade of EGFR and HER2 by New-Generation EGFR Tyrosine Kinase Inhibitor Enhances Radiation Effect in Bladder Cancer Cells.

ERBB2 EGFR

5.49e-06282225589492
Pubmed

Protein overexpression and gene amplification of HER-2 and EGFR in colorectal cancers: an immunohistochemical and fluorescent in situ hybridization study.

ERBB2 EGFR

5.49e-06282215143334
Pubmed

An EGFR/HER2-Bispecific and enediyne-energized fusion protein shows high efficacy against esophageal cancer.

ERBB2 EGFR

5.49e-06282224664246
Pubmed

Impact of common epidermal growth factor receptor and HER2 variants on receptor activity and inhibition by lapatinib.

ERBB2 EGFR

5.49e-06282218199554
Pubmed

Status of HER1 and HER2 in peritoneal, ovarian and colorectal endometriosis and ovarian endometrioid adenocarcinoma.

ERBB2 EGFR

5.49e-06282219294416
Pubmed

Expression of erbB-1 and erbB-2 genes in normal and pathological human endometrium.

ERBB2 EGFR

5.49e-06282217549377
Pubmed

Prognostic implications of EGFR and HER-2 alteration assessed by immunohistochemistry and silver in situ hybridization in gastric cancer patients following curative resection.

ERBB2 EGFR

5.49e-06282223955257
Pubmed

Cooverexpression of ERBB1 and ERBB4 receptors predicts poor clinical outcome in pN+ oral squamous cell carcinoma with extranodal spread.

ERBB4 EGFR

5.49e-06282224338375
Pubmed

The efficient elimination of solid tumor cells by EGFR-specific and HER2-specific scFv-SNAP fusion proteins conjugated to benzylguanine-modified auristatin F.

ERBB2 EGFR

5.49e-06282227502168
Pubmed

Frequent genetic alterations in EGFR- and HER2-driven pathways in breast cancer brain metastases.

ERBB2 EGFR

5.49e-06282223665199
Pubmed

Epidermal growth factor receptor activity is necessary for mouse basal cell proliferation.

ERBB2 EGFR

5.49e-06282225217659
Pubmed

EGFR and HER2 expression in advanced biliary tract cancer.

ERBB2 EGFR

5.49e-06282219777609
Pubmed

Neuregulin receptors erbB2 and erbB4 in failing human myocardium -- depressed expression and attenuated activation.

ERBB2 ERBB4

5.49e-06282215685397
Pubmed

Differential cytoskeletal association of ErbB1 and ErbB2 during keratinocyte differentiation.

ERBB2 EGFR

5.49e-06282212135609
Pubmed

Dual inhibition of ErbB1 and ErbB2 in cancer by recombinant human prolidase mutant hPEPD-G278D.

ERBB2 EGFR

5.49e-06282227286447
Pubmed

Increased concentrations of growth factors and activation of the EGFR system in breast cancer.

ERBB2 EGFR

5.49e-06282223089711
Pubmed

EGFR Expression in HER2-Driven Breast Cancer Cells.

ERBB2 EGFR

5.49e-06282233260837
Pubmed

Membrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2.

ERBB2 EGFR

5.49e-06282222451678
Pubmed

The immune microenvironment in EGFR- and ERBB2-mutated lung adenocarcinoma.

ERBB2 EGFR

5.49e-06282234487971
Pubmed

Screening and validation of dinucleotide repeats in intron 1 of the human EGFR gene and its paralog in the HER2 gene.

ERBB2 EGFR

5.49e-06282218946768
Pubmed

Dissecting the molecular recognition of dual lapatinib derivatives for EGFR/HER2.

ERBB2 EGFR

5.49e-06282231828486
Pubmed

Design, biological evaluation and 3D QSAR studies of novel dioxin-containing pyrazoline derivatives with thiourea skeleton as selective HER-2 inhibitors.

ERBB2 EGFR

5.49e-06282227273260
Pubmed

Association of EGFR and HER2 polymorphisms with risk and clinical features of thyroid cancer.

ERBB2 EGFR

5.49e-06282219860576
Pubmed

Androgen receptor controls EGFR and ERBB2 gene expression at different levels in prostate cancer cell lines.

ERBB2 EGFR

5.49e-06282219318561
Pubmed

Induction of cancer cell migration by epidermal growth factor is initiated by specific phosphorylation of tyrosine 1248 of c-erbB-2 receptor via EGFR.

ERBB2 EGFR

5.49e-06282212354693
InteractionMUC4 interactions

ERBB2 ERBB4 EGFR

5.16e-069813int:MUC4
InteractionPTPRT interactions

ERBB2 ERBB4 EGFR

1.01e-0511813int:PTPRT
Cytoband3p25

BTD CAV3

4.21e-04178223p25
GeneFamilyErb-b2 receptor tyrosine kinases

ERBB2 ERBB4 EGFR

7.95e-0845031096
GeneFamilySolute carriers

SLC6A13 SLC9A5 SLC2A9 SLC6A16 SLC25A14 SLC25A30

7.38e-04395506752
GeneFamilyFibronectin type III domain containing

ROBO4 CNTN5 IGSF9 CDON

9.91e-04160504555
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

ROBO4 CNTN5 IGSF9 CDON

1.01e-03161504593
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

TADA2B HERC2

1.11e-031850291
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

CD93 PKD1

5.74e-03415021298
CoexpressionAtlasthyroid gland

RAP1GAP CNTN5 TLE6 OVCH1 MPPED2 PKHD1L1 CDON

3.40e-05240807thyroid gland
CoexpressionAtlasalpha beta T cells, T.4Nve.LN, 4+ 8- 25- 62Lhi 44lo, Lymph Node, avg-3

CRIM1 ZNRF3 PACSIN1 PRF1 ITGA6 MARK2 CDON TECPR1

3.89e-05336808GSM538374_500
CoexpressionAtlasalpha beta T cells, T.4.PLN.BDC, 4+ 8- BDC+, Lymph Node, avg-3

CRIM1 ZNRF3 PACSIN1 ITGA6 MARK2 IL17RB CDON TECPR1

3.89e-05336808GSM605758_500
CoexpressionAtlasalpha beta T cells, T.4.TI.B16, 4+ 8- TCR+ 45+, B16 Melanoma Tumor, avg-3

CRIM1 ZNRF3 PACSIN1 PRF1 ITGA6 MARK2 CDON TECPR1

4.06e-05338808GSM605763_500
CoexpressionAtlasfacebase_RNAseq_e14.5_palate_poster_nasal_Tgfbr2_WT_2500_K2

SLC6A13 CTSF RAP1GAP GALM EGFR NYNRIN PKD1 BACE1 TLE6 ALPK1 IDH2 GK5 MPPED2 BAIAP2L2 CDON

4.73e-0512288015facebase_RNAseq_e14.5_palate_poster_nasal_Tgfbr2_WT_2500_K2
CoexpressionAtlasalpha beta T cells, NKT.4+.Lv, CD45 TCRb aGalCer-loaded CD1d tet CD4, Liver, avg-4

CD93 CRIM1 ZNRF3 PRF1 PPP1R15A IL17RB CDON TECPR1

5.19e-05350808GSM538318_500
CoexpressionAtlasalpha beta T cells, NKT.4-.Lv, CD45 TCRb aGalCer-loaded CD1d tet, Liver, avg-4

CD93 CRIM1 ZNRF3 PRF1 PPP1R15A IL17RB CDON TECPR1

5.30e-05351808GSM538325_500
CoexpressionAtlasalpha beta T cells, T.4.LN.BDC, 4+ 8- BDC+, Lymph Node, avg-3

CRIM1 ZNRF3 PACSIN1 PRF1 ITGA6 MARK2 IL17RB TECPR1

5.62e-05354808GSM605753_500
CoexpressionAtlasalpha beta T cells, T.8Nve.MLN, 4- 8+ 25- 62Lhi 44lo, Lymph Node, avg-3

MDN1 CRIM1 ZNRF3 PACSIN1 PRF1 BACE1 MARK2 TECPR1

5.85e-05356808GSM538409_500
CoexpressionAtlasCD positive, CD4 Test JS, 4+8-B220-, Spleen, avg-3

CRIM1 ZNRF3 PACSIN1 PRF1 ITGA6 MARK2 CDON TECPR1

6.20e-05359808GSM404000_500
CoexpressionAtlasalpha beta T cells, T.4FP3-.Sp, 4+ 8- GFP- 44lo, Spleen, avg-3

CRIM1 ZNRF3 PACSIN1 PRF1 ITGA6 MARK2 CDON TECPR1

6.83e-05364808GSM605766_500
CoexpressionAtlasalpha beta T cells, T.8Mem.Sp, 4- 8+ 25- 44hi 122hi, Spleen, avg-3

MDN1 CRIM1 ZNRF3 PACSIN1 PRF1 CRYBG1 TECPR1

1.47e-04303807GSM538398_500
CoexpressionAtlasalpha beta T cells, T.4Nve.PP, TCR+ CD4+ CD44low CD62Lhigh, Peyer's Patch, avg-2

MDN1 ZNRF3 PACSIN1 ITGA6 CRYBG1 PPP1R15A TECPR1

2.34e-04327807GSM538380_500
CoexpressionAtlasalpha beta T cells, T.8Nve.LN, 4- 8+ 25- 62Lhi 44lo, Lymph Node, avg-3

CRIM1 ZNRF3 PACSIN1 PRF1 ITGA6 MARK2 TECPR1

2.66e-04334807GSM538406_500
CoexpressionAtlasalpha beta T cells, T.8.Sp.B16, 4- 8+ TCR+ 45+, B16 Melanoma Spleen, avg-3

MDN1 CRIM1 ZNRF3 PACSIN1 PRF1 ITGA6 TECPR1

2.71e-04335807GSM605770_500
CoexpressionAtlasCD positive, CD4 Test DB, 4+8-B220-, Spleen, avg-1

MDN1 CRIM1 ZNRF3 PACSIN1 PRF1 ITGA6 TECPR1

2.86e-04338807GSM403987_500
CoexpressionAtlasalpha beta T cells, T.4Mem.Sp, 4+ 8- 25- 44hi 122lo, Spleen, avg-3

GALM CRIM1 PACSIN1 ITGA6 IL17RB CDON TECPR1

3.12e-04343807GSM538365_500
CoexpressionAtlasCD positive, CD4 Test NA, 4+8-B220-, Spleen, avg-1

CRIM1 ZNRF3 PACSIN1 PRF1 ITGA6 CDON TECPR1

3.97e-04357807GSM403986_500
CoexpressionAtlasalpha beta T cells, T.4SP24-.Th, 4+ 8- TCRhi 24-/lo, Thymus, avg-3

ZNRF3 PACSIN1 ITGA6 CRYBG1 MARK2 CDON TECPR1

4.53e-04365807GSM399370_500
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A13 GALM SLC2A9 CDHR5 ABCC6 BAIAP2L2 IL17RB

5.59e-081878271b82920588f9e26ef1db244d452736d75fcfd342
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A13 GALM SLC2A9 CDHR5 ABCC6 BAIAP2L2 IL17RB

5.59e-08187827c1e4c0345f9bfa0538730bad5ff3fa5240168b25
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A13 GALM SLC2A9 CDHR5 ABCC6 BAIAP2L2

1.24e-06186826a417e1e21313a7e05951038cdef5ac672a9f727c
ToppCell356C-Endothelial_cells-Endothelial-E-|356C / Donor, Lineage, Cell class and subclass (all cells)

CD93 CRIM1 S100A16 IDO1 ITGA6 TECPR1

1.24e-061868262e024097ee361eeb1d855a4edb8ac8cdad35da06
ToppCell356C-Endothelial_cells-Endothelial-E|356C / Donor, Lineage, Cell class and subclass (all cells)

CD93 CRIM1 S100A16 IDO1 ITGA6 TECPR1

1.24e-06186826c3449e54454009973818fc1101933c6f0168258c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A13 CMIP SLC2A9 CNTN5 ITGA6 CDHR5

1.24e-06186826b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A13 GALM SLC2A9 CDHR5 ABCC6 IL17RB

1.28e-0618782671eb26ebf60cb0848e5bf1cd01edccda621aecd8
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A13 GALM SLC2A9 CDHR5 ABCC6 IL17RB

1.32e-06188826f3edcefeef2ce19086032d98b243c02a6d542b38
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A13 GALM SLC2A9 CDHR5 ABCC6 IL17RB

1.32e-061888260792432cd4c564dea1102241ea9884f7ced7658c
ToppCellParenchyma_COVID-19-Endothelial-TX-Endothelial-2|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

CD93 ROBO4 IDO1 BTNL3 BEX5 ITGA6

1.84e-06199826edb68a4f622a494f22fd7b25bc40ae0d58456cdb
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Endothelial-2|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CD93 ROBO4 IDO1 BTNL3 BEX5 ITGA6

1.84e-06199826448dd5a27d57627468c6b8347f1b6b1005aea004
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Endothelial-2-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CD93 ROBO4 IDO1 BTNL3 BEX5 ITGA6

1.84e-0619982645f9c03d2ed2d98d66086fb0251bd24e30c6f775
ToppCellVE-CD8-memory_CD4|VE / Condition, Cell_class and T cell subcluster

RCC1L PRF1 ITGA6 LMOD2 SCN3B

9.12e-061528259401b7770c1bdc87eba25e82922f5dd1c4fa37ee
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD93 ROBO4 S100A16 IDO1 SCN3B

1.07e-051578252c946c6ab284fac3c25db688ed0aabe5a3f9ffa5
ToppCellPND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD93 ROBO4 S100A16 SLC25A30 SCN3B

1.48e-0516882555c9de7b3a1d6cf7b02b020ff92ab4ede8d195cc
ToppCellNS-critical-d_0-4-Epithelial-Secretory|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ERBB2 CTSF RAP1GAP EGFR IGSF9

1.52e-05169825aec97583b23112060437b619cb429dc32f29285f
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

USP2 ERBB4 RAP1GAP NYNRIN CASK

1.70e-051738257a3115e7cf7e2f345192cde0656a7f0193594a5f
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A13 GALM SLC2A9 CDHR5 ABCC6

1.85e-051768251595dbeee336a81e581325d63208ec6262664ee9
ToppCellPND07-28-samps-Endothelial-Postnatal_endothelial-endothelial_cells_C|PND07-28-samps / Age Group, Lineage, Cell class and subclass

CD93 ROBO4 S100A16 IDO1 TECPR1

1.90e-051778256da88c358b3a2e47fa3472217a38b6b00ad7b280
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A13 SLC2A9 CDHR5 ABCC6 IL17RB

2.17e-05182825e1e58176f533092b6b974ca1ce8b02192a6e193d
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A13 SLC2A9 CDHR5 ABCC6 IL17RB

2.17e-051828254a9c13932e7163fd37a3dcc4c6ca3bbea5372459
ToppCellP28-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CD93 S100A16 ITGA6 PPP1R15A SCN3B

2.17e-05182825db5d6c5e7d59734653906b126f2c1d57461a5290
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A13 SLC2A9 CDHR5 ABCC6 IL17RB

2.17e-0518282557bb5a2da976464ba7c4460106bd9f692008ebd9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A13 SLC2A9 CDHR5 ABCC6 IL17RB

2.23e-0518382584b64cf728629c3af9a8d2ed15b93adf562c54b8
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A13 GALM SLC2A9 CDHR5 BAIAP2L2

2.29e-051848259434731f651820b05335085582960f08fbf895de
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A13 GALM SLC2A9 CDHR5 ABCC6

2.41e-051868258287146f0ba415ea04475588117d4668ae00f75c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

USP2 SLC6A13 CMIP SLC2A9 ZNRF3

2.41e-051868255784d255e9ca449d375d81938d0fbbd8a7eb44f6
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

USP2 ERBB4 RAP1GAP LTBP2 IDH2

2.48e-05187825b93cf4dfe8ffb89348ee7bccc9f284189f7240a2
ToppCellE17.5-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.48e-05187825e9aa0a5a0f8e2593de63e83b56b53ae33e60af49
ToppCellE17.5-Endothelial-unknown_endothelial_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CD93 ROBO4 S100A16 MPPED2 SCN3B

2.48e-05187825da885c26ccc5189b1ff1f607552e00a5c0e49e7e
ToppCellE17.5-Endothelial-capillary_endothelial_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.48e-0518782561b8a53f29bb8b33c69f680b8359a1143a23999d
ToppCell3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CD93 ROBO4 S100A16 ITGA6 TECPR1

2.48e-051878250ef82111b9049cc7ee78d64d240e1f10ab14d6b6
ToppCellE17.5-Endothelial-unknown_endothelial_cell-endothelial_unknown_1|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CD93 ROBO4 S100A16 MPPED2 SCN3B

2.48e-051878251f358d02ec69d44dea2e2831af9473ed05dcf8cc
ToppCellThalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn_(Dcn)|Thalamus / BrainAtlas - Mouse McCarroll V32

SLC6A13 CRYGS PRF1 LOXL4

2.53e-0592824bbaf5a131f860198840e34843b7c841bcc98d9c4
ToppCellThalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn_(Dcn)-|Thalamus / BrainAtlas - Mouse McCarroll V32

SLC6A13 CRYGS PRF1 LOXL4

2.53e-0592824e6aa2b8ca9235a7291ee41d976b886fec185835d
ToppCellP28-Endothelial-large_vessel_endothelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CD93 CMIP CRIM1 S100A16 PPP1R15A

2.54e-05188825263169029293e005bcffd87db20221fdd2d3917e
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CTSF SLC2A9 EGFR LAMA2 LTBP2

2.60e-05189825f7d57723b8fb0f1e1485f51e3eff93ec0f39761e
ToppCellP07-Endothelial-unknown_endothelial_cell-endothelial_unknown_1|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CD93 S100A16 MPPED2 SCN3B TECPR1

2.60e-05189825fcfb28bd96471affc13e55aa7228f594aaa967cd
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A13 GALM SLC2A9 ABCC6 IL17RB

2.60e-0518982513fd07cc408a9486f61a7b2c3a132c52d14b438d
ToppCellP07-Endothelial-unknown_endothelial_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CD93 S100A16 MPPED2 SCN3B TECPR1

2.60e-05189825f515a04ae1746257d4568cea13a3dd75b4b05275
ToppCellControl-Endothelial-VE_Capillary_B|Endothelial / Disease state, Lineage and Cell class

CD93 EGFR BEX5 LAMA2 ITGA6

2.67e-051908257f3f419fffe02934b6f27b697f7a6401072491ed
ToppCellCOPD-Lymphoid-T_Cytotoxic|Lymphoid / Disease state, Lineage and Cell class

CMIP GALM PRF1 AOAH CRYBG1

2.67e-0519082510bece40d980d37a01dae8ce887655bf9f93040c
ToppCellfacs-MAT-Fat-18m-Endothelial|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD93 ROBO4 CRIM1 ITGA6 CDHR5

2.67e-0519082534e56c5e7ea6a8f227dbaefe73cbb8818d18b523
ToppCellfacs-MAT-Fat-18m-Endothelial-nan|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD93 ROBO4 CRIM1 ITGA6 CDHR5

2.67e-0519082514cdb660ad3aabcf49572173e7628d8b99dcbe6f
ToppCell(2)_Fibroblasts-(21)_Fibro-2|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis

S100A16 EGFR ITGA6 CDHR5 DNASE2

2.67e-05190825d2afa08ad868acc6fce308ec21b0bf93591d4010
ToppCellE17.5-Endothelial|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.67e-051908254fb76195ec9d6e0260a628eef6c2b3705acce787
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.67e-051908256847afca73e1b76c2e86187ccb1a164aefd8f17b
ToppCellfacs-MAT-Fat-18m-Endothelial-endothelial_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD93 ROBO4 CRIM1 ITGA6 CDHR5

2.67e-051908259aaa48f3aad813c87a45efdbb67d255c94f6e6a4
ToppCellfacs-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.74e-0519182538fe60a8570f3c6eb8e8f8646f90d505dfd7d647
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

USP2 ERBB4 RAP1GAP LTBP2 IDH2

2.74e-05191825f631749ef1f2270133664cf5eb4cf545a8482bd3
ToppCellfacs-Lung-3m-Endothelial-capillary_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.74e-051918250e6cd2628a5cebd35e960e4eb3b52ddc9358031c
ToppCell(2)_Fibroblasts-(21)_Fibro-2|World / Cell class and subclass of bone marrow stroma cells in homeostatis

EGFR ITGA6 CDHR5 DNASE2 CDON

2.74e-051918255ee353c79055c08e8a3e2b43a0345bceb09f3890
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GALM ITGA6 CRYBG1 PPP1R15A CASK

2.74e-05191825142f98cabf8737b28369315b3d7a0797ded88e03
ToppCellRA-09._Endothelium_I|World / Chamber and Cluster_Paper

ROBO4 CMIP CRIM1 ITGA6 PKHD1L1

2.74e-05191825c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCelldroplet-Kidney-nan-18m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERBB4 RAP1GAP ITGA6 IDH2 BAIAP2L2

2.81e-05192825e19e3e8edcc08e4a67873bfb6e46489ca6c8756a
ToppCellPCW_07-8.5-Endothelial-Endothelial_cycling-endo_proliferating2_(14)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.81e-05192825ac3d87aa301d30515c369bd7fc16f33b82173a85
ToppCellEndothelial-A|World / shred on cell class and cell subclass (v4)

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.81e-051928259919cdc0ce833894525dba429f251ea1b094fbd8
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.81e-051928251a3f24607cb49aa610c183f4c2b7d735f484a3a4
ToppCellEndothelial|World / shred on cell class and cell subclass (v4)

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.81e-051928252b13cca5c4b58628dbbbb356859632dba66d43f9
ToppCelldroplet-Kidney-nan-18m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERBB4 RAP1GAP ITGA6 IDH2 BAIAP2L2

2.81e-0519282561c2caf6c838132ed5faa8791c288f2149eba2c8
ToppCelldroplet-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.81e-051928256b69bb8fab9b470850eba1a070a500435ec233cd
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.81e-05192825c8dcd75d695d09adff083af8d5a64cf15fe027d4
ToppCellPCW_07-8.5-Endothelial-Endothelial_immature-endo_immature_arterial1_(12)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CD93 ROBO4 S100A16 CRYBG1 SCN3B

2.88e-05193825d338a7c0585b69947c37f44aa0381619493e31ea
ToppCelldroplet-Lung-nan-3m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.88e-051938257cff1e859b296b1032eebcfc0f99a504f3bda2c9
ToppCellIPF-Lymphoid-T_Cytotoxic|Lymphoid / Disease state, Lineage and Cell class

CMIP GALM PRF1 AOAH CRYBG1

2.88e-051938253c8a022dbd4f8d25b14fd137ce64c2713a7dbe41
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.88e-05193825f4dd52491254ce321bc4d0dad988a7ce5970f52d
ToppCellPND10-Endothelial-Endothelial_blood-vessel|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.88e-051938251d8acf81dcbfe81c7a73ce50c9f38fe0cbc74486
ToppCellPND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.88e-05193825b7c0b4dbbe11f86cff6371d3d12a6b772b938d78
ToppCelldroplet-Lung-3m-Endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.88e-0519382595c9c63bddfed1a84393ccd3578cfe65bc0c1c05
ToppCellPND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.88e-05193825e44d777f65b907f299cefd73296805ac4c92d383
ToppCellP15-Endothelial-large_vessel_endothelial_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CD93 CMIP CRIM1 S100A16 PPP1R15A

2.88e-051938255f9a7cd5f8eb9ac294cdb50518fedf872f3f78f5
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.88e-05193825097a244cf37ce6c1ace9bae56beb7de59442cd6b
ToppCellPND10-Endothelial|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.88e-05193825f3c743b340fc588bc8effd375b12e2c7cbfa49d2
ToppCellPND14-Endothelial|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.95e-05194825cee89d4340738f09d07a159cd6aeee4300776988
ToppCelldroplet-Lung-1m-Endothelial-capillary_endothelial-capillary_endothelial_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CD93 ROBO4 S100A16 MPPED2 SCN3B

2.95e-05194825e13923860a64ba9cf32df53c9f0cf4e7c321881d
ToppCellPND14-Endothelial-Endothelial_blood-vessel|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.95e-0519482532962060d80f3edffbe9f0ecad3000c3a9817865
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.95e-051948252c78e754cac848fd47172f94e392749eb0ab50d4
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.95e-051948251b382508453c5b08fb617f626b230adf3b6cff99
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

CRIM1 PACSIN1 PRF1 AOAH IDH2

2.95e-05194825b0a7f5ca0c6f4f5764a8b35b5de80d82b828c66c
ToppCellPND07-Endothelial-Endothelial_blood-vessel|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.95e-0519482512496bc964d1c572241410524a89ca1a9fdb7e34
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.95e-0519482592a8e6e3e3f6fd9dacb723b58e7a8b63473e403e
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.95e-0519482546e36817fd1ed27af8013375214c38c9a9271640
ToppCellPND07-Endothelial|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.95e-05194825d1080c86884916c22894b27994141463f5919812
ToppCellCOPD-Endothelial-VE_Capillary_B|COPD / Disease state, Lineage and Cell class

CD93 ROBO4 S100A16 EGFR ITGA6

2.95e-0519482518b7f901c12ca4f21f9a1eafd092aefe4d668b6d
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.95e-05194825c6cee7d15af76f9a60d7f414ef0bcc1735c47b7a
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.95e-0519482544c7d4b75f3b7c9301eba20610e548a01a84ae40
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD93 ROBO4 S100A16 ITGA6 SCN3B

2.95e-051948257f24023df47935286f185dd428d48797daf26f49
ToppCelldroplet-Lung-1m-Endothelial-capillary_endothelial|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CD93 ROBO4 S100A16 MPPED2 SCN3B

2.95e-0519482586508dd9b9d345b6624d185048cc92b81dd11c2a
ToppCell367C-Endothelial_cells-Endothelial-E-|367C / Donor, Lineage, Cell class and subclass (all cells)

CD93 ROBO4 S100A16 BEX5 ITGA6

3.02e-0519582565fc50e3818e902028fc4226070fa57609c66b9c
ToppCell367C-Endothelial_cells-Endothelial-E|367C / Donor, Lineage, Cell class and subclass (all cells)

CD93 ROBO4 S100A16 BEX5 ITGA6

3.02e-051958253b79e6bb525b17192ecec9e1227a29c419968144
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD93 ROBO4 S100A16 ITGA6 SCN3B

3.02e-05195825cd011433b3b9bfb1adb13eca2f3f2a5db024cd94
ToppCellPCW_13-14-Endothelial-Endothelial_immature-endo_immature2_(1)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CD93 ROBO4 S100A16 ITGA6 SCN3B

3.10e-05196825b0288e28a6e6222a9e310eb6fe228c04b618db13
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

USP2 ERBB4 RAP1GAP IDH2 CASK

3.10e-051968251bfc3c85ce9501f52a912e53cbded7de74572b9d
ToppCellFetal_29-31_weeks-Endothelial|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CD93 ROBO4 ITGA6 PKHD1L1 SCN3B

3.10e-051968253981f6c7487598f4f7ce4650ac0ac5bd41481d66
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

USP2 ERBB4 RAP1GAP IDH2 CASK

3.10e-05196825e02301642243df483fd066d978317c113c04692b
ToppCell3'-GW_trimst-1.5-LargeIntestine-Endothelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CD93 ROBO4 S100A16 ITGA6 PKHD1L1

3.10e-05196825629236f95c838a473b5964a49b7c1b7ad863ea12
ToppCellParenchyma_Control_(B.)-Endothelial-TX-Endothelial-1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

CD93 ROBO4 CRIM1 ITGA6 PKHD1L1

3.18e-05197825f969685dee212f33a6f09e54c0cd1fd24ffef546
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial-Endothelial-1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

CD93 ROBO4 CRIM1 ITGA6 PKHD1L1

3.18e-051978251a137af40697137bb9d2b5caf2b1ffda55f04461
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

USP2 ERBB4 RAP1GAP LTBP2 IDH2

3.18e-051978254ea3f57cd88b8a6bb7cb4b9e3545c0fa8f331886
ToppCelldistal-Endothelial-Bronchial_Vessel_1-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CD93 ROBO4 CMIP CRIM1 S100A16

3.18e-051978250d1afd1ad7489c071db08b3dfff598423097d7e0
Drugpyrido[3,4-d]pyrimidine

ERBB2 ERBB4 EGFR

4.34e-083813CID014758064
Drugamiloride

ERBB2 ERBB4 SLC9A5 RNLS EGFR PKD1 LOXL4 PRKCG CNGA2 SCN3B

1.76e-073158110CID000016230
Drug6-(methylamino)pyrido(3,4-d)pyrimidine

ERBB2 ERBB4 EGFR

5.11e-0610813ctd:C107875
DrugBE-23372M

ERBB2 ERBB4 EGFR

7.01e-0611813CID005311105
DrugTapi

ERBB2 EGFR PRF1 BACE1 MARK2

9.81e-0680815CID003035404
DrugCMF regimen

ERBB2 EGFR IDO1

1.21e-0513813ctd:C034456
DrugAC1L9JR2

ERBB4 ERF EGFR

1.21e-0513813CID000446506
DrugN-(2-(4-((3-chloro-4-(3-(trifluoromethyl)phenoxy)phenyl)amino)-5H-pyrrolo(3,2-d)pyrimidin-5-yl)ethyl)-3-hydroxy-3-methylbutanamide

ERBB2 EGFR

1.25e-052812ctd:C570404
DrugLapatinib

ERBB2 EGFR

1.25e-052812DB01259
DrugAG213

ERBB4 EGFR CNTN5 ITGA6 PRKCG

1.65e-0589815CID005328803
Drugamoxapine

SLC6A13 RNLS SLC6A16 LOXL4

2.16e-0546814CID000002170
Drugnitecapone

RNLS ITGA6 LOXL4

2.35e-0516813CID005464105
Drug4-anilinoquinazoline

ERBB2 ERBB4 EGFR

2.35e-0516813CID000324081
Drug4-HT

ERBB2 ERBB4 EGFR ACO2 ITGA6

3.68e-05105815CID005284643
Drug5-iodonicotinic acid

ERBB2 EGFR

3.74e-053812CID000151950
Drug2-acetamidoethanethiol

ERBB2 EGFR

3.74e-053812ctd:C023704
Drug4557 W

ERBB2 EGFR

3.74e-053812ctd:C433938
Drug4-aminopyrimidine-5-carbaldehyde

ERBB2 EGFR

3.74e-053812CID011228787
Drugnorfenefrine

RNLS PRF1 LOXL4

4.03e-0519813CID000004538
DrugPC9

ERBB2 ERBB4 ERF EGFR

5.83e-0559814CID016040245
DrugReserpine [50-55-5]; Up 200; 6.6uM; PC3; HT_HG-U133A

ROBO4 SLC2A9 BTNL3 GLB1L LAMA2 SCN3B

6.96e-051958164203_UP
DrugSolasodine [126-17-0]; Down 200; 9.6uM; MCF7; HT_HG-U133A

ERBB2 LTBP2 ALPK1 MARK2 PPP1R15A CDON

7.36e-051978163924_DN
DrugPD168393

ERBB4 EGFR

7.47e-054812CID000004708
Drugtyrphostin AG825

ERBB2 EGFR

7.47e-054812CID000002062
DrugCHX-A

ERBB2 BTD

7.47e-054812CID000164445
DrugEGFR/ErbB2 inhibitor

ERBB2 EGFR

7.47e-054812CID009843206
DrugRapamycin; Up 200; 0.1uM; HL60; HT_HG-U133A

CTSF CNTN5 AOAH BACE1 LTBP2 CDON

8.00e-052008166167_UP
DrugAC1NE222

CD93 ERBB2 ERBB4 EGFR

8.53e-0565814CID004635324
DrugBIBX1382BS

ERBB2 ERBB4 EGFR

1.06e-0426813CID006918508
DrugN-(2-chloroethyl)-N-ethyl-2-bromobenzylamine

SLC6A13 RNLS SLC6A16 LOXL4

1.08e-0469814CID000003172
Drugdocetaxel

ERBB2 EGFR ACO2 IDH2 ABCC6

1.13e-04133815ctd:C067311
Drugbenzylidenemalononitrile

ERBB2 ERBB4 EGFR

1.19e-0427813CID000017608
Drugsodium

SLC6A13 ERBB2 SLC9A5 GALM SLC2A9 SLC6A16 PRF1 PKD1 PRKCG IDH2 CAV3 SCN3B

1.22e-049448112CID000000923
DrugRG 14921

ERBB4 EGFR

1.24e-045812CID000197517
Drug6-quinolinecarbaldehyde

ERBB4 EGFR

1.24e-045812CID000765653
DrugTAK-165

ERBB2 EGFR

1.24e-045812CID006444692
DrugAnilino

ERBB2 EGFR PRKCG

1.48e-0429813CID000137550
Drug1 x OE

ERBB2 ERBB4 EGFR

1.64e-0430813CID000449200
DrugB-31

ERBB2 EGFR

1.86e-046812CID000122475
DrugCochliobolic acid

ERBB4 EGFR

1.86e-046812CID006450172
DrugT 794

RNLS LOXL4

1.86e-046812CID003077680
DrugNSD 2023

RNLS LOXL4

1.86e-046812CID000019831
Drugoxalomalic acid

ACO2 IDH2

1.86e-046812CID000439620
Drug1-benzyl-2-methyl-5-methoxytryptamine

RNLS LOXL4

1.86e-046812CID000009925
DrugBU99006

RNLS LOXL4

1.86e-046812CID006603748
Drug5-hydroxyisatin

RNLS LOXL4

1.86e-046812CID010352011
DrugSnCe6

ERBB4 EGFR

1.86e-046812CID000164259
Drug1-PCPA

RNLS LOXL4

1.86e-046812CID000194548
DrugN-cyclopropyl-5,6-dimethoxytryptamine

RNLS LOXL4

1.86e-046812CID000156277
DrugN-cyclopropyl-6,7-dimethoxytryptamine

RNLS LOXL4

1.86e-046812CID000156278
DrugN-cyclopropyl-alpha-methylbenzylamine

RNLS LOXL4

1.86e-046812CID000362778
DrugZD-6

ERBB2 EGFR

1.86e-046812CID010062753
Drugdiethyl ester

ERBB4 EGFR

1.86e-046812CID000264327
Drugnicotinamide ribose

IDO1 IGSF9 IDH2 ABCC6

2.11e-0482814CID000000940
Druglactate

MPV17 ROBO4 GALM BTD ACO2 WBP2NL IDH2 SCN3B

2.35e-04461818CID000000612
Drugharmaline

SLC9A5 RNLS LOXL4

2.40e-0434813CID000022381
Drugdimethylphenethylamine

RNLS LOXL4

2.59e-047812CID000025124
DrugBU 224

RNLS LOXL4

2.59e-047812CID000002457
DrugN-(2-aminoethyl)benzamide

RNLS LOXL4

2.59e-047812CID000423156
Drugcimoxatone

RNLS LOXL4

2.59e-047812CID000052542
DrugRG 14467

ERBB4 EGFR

2.59e-047812CID000132069
Drugtetrahydroharmine

RNLS LOXL4

2.59e-047812CID000159809
Drug4'-amino-MPTP

RNLS LOXL4

2.59e-047812CID000086263
DrugPKI 166

ERBB2 EGFR

2.59e-047812ctd:C410026
DrugJB 835

RNLS LOXL4

2.59e-047812CID000152988
Drug1-benzylcyclopropylamine

RNLS LOXL4

2.59e-047812CID000152923
Drugsecoisolariciresinol diglucoside

ERBB2 EGFR

2.59e-047812ctd:C090142
DrugMPTP-3-ol

RNLS LOXL4

2.59e-047812CID000100194
DrugSSFSB

ERBB4 EGFR

2.59e-047812CID003035734
DrugM 2113

RNLS LOXL4

2.59e-047812CID000072895
Drugiproclozide

RNLS LOXL4

2.59e-047812CID000019063
DrugAC1L1JJ0

ERBB2 EGFR

2.59e-047812CID000005061
Drugbrofaromine

RNLS LOXL4

2.59e-047812CID000044570
Drugdeazapurine

ERBB2 EGFR

2.59e-047812CID000261591
Drug4-methoxytranylcypromine

RNLS LOXL4

2.59e-047812CID003082143
Drug1-Phenylcyclobutylamine

RNLS LOXL4

2.59e-047812CID000152214
DrugRS-2232

RNLS LOXL4

2.59e-047812CID000134882
DrugSR 95191

RNLS LOXL4

2.59e-047812CID000072119
Drug4-hydroxynonenal

ERBB2 ERBB4 EGFR ACO2 BACE1 ITGA6 PRKCG IDH2

2.71e-04471818CID000001693
DrugalphaNMN

ERF RNLS LOXL4 IDH2

3.01e-0490814CID000000939
Drugsipatrigine

SLC6A13 SLC6A16 SCN3B

3.09e-0437813CID000060803
Drug2-propynylamine

RNLS LOXL4 PRKCG

3.09e-0437813CID000239041
Drugglucose-6-P

CTSF GALM SLC2A9 PRF1 ACO2 IDH2 CREG1

3.28e-04366817CID000000208
DrugAC1O5VTH

RNLS LOXL4

3.45e-048812CID006441710
DrugAC1Q6B1A

RNLS LOXL4

3.45e-048812CID000088562
DrugFolfox protocol

ERBB2 EGFR

3.45e-048812ctd:C410216
Drugpyrazidol

RNLS LOXL4

3.45e-048812CID000068802
DrugI50 - 9

ERBB4 EGFR

3.45e-048812CID000083651
Drugcitrazinic acid

ACO2 IDH2

3.45e-048812CID000007425
Drugamezinium

RNLS LOXL4

3.45e-048812CID000071926
Drugmebanazine

RNLS LOXL4

3.45e-048812CID000006179
Drugmofegiline

RNLS LOXL4

3.45e-048812CID006437850
Drug4-fluorotranylcypromine

RNLS LOXL4

3.45e-048812CID003082666
Drugranbezolid

RNLS LOXL4

3.45e-048812CID000496993
Drug2-propyl-pentylamine

RNLS LOXL4

3.45e-048812CID000170419
Drug2-methylcitric acid

ACO2 IDH2 CDON

3.61e-0439813CID000000515
Diseaselaryngeal squamous cell carcinoma (is_marker_for)

ERBB2 ERBB4 EGFR CDC73

1.79e-0719794DOID:2876 (is_marker_for)
Diseasehead and neck squamous cell carcinoma (is_marker_for)

ERBB2 ERBB4 CDC73

1.02e-068793DOID:5520 (is_marker_for)
DiseaseHead and Neck Carcinoma

ERBB2 EGFR CDC73

2.19e-0610793C3887461
Diseasegallbladder neoplasm

ERBB2 ERBB4 EGFR

3.00e-0611793C0016978
DiseaseMalignant neoplasm of gallbladder

ERBB2 ERBB4 EGFR

3.00e-0611793C0153452
DiseaseNeoplasm Recurrence, Local

ERBB2 EGFR IDO1 IDH2

3.64e-0639794C0027643
Diseasemedian neuropathy (biomarker_via_orthology)

ERBB2 ERBB4 EGFR

6.58e-0614793DOID:571 (biomarker_via_orthology)
Diseaseoral squamous cell carcinoma (is_marker_for)

ERBB2 ERBB4 EGFR CDC73

2.51e-0563794DOID:0050866 (is_marker_for)
DiseaseIntrahepatic Cholangiocarcinoma

ERBB2 EGFR IDH2

3.59e-0524793C0345905
DiseaseExtrahepatic Cholangiocarcinoma

ERBB2 EGFR IDH2

3.59e-0524793C3805278
DiseaseCholangiocarcinoma

ERBB2 EGFR IDH2

4.59e-0526793C0206698
Diseasedilated cardiomyopathy (implicated_via_orthology)

ERBB2 EGFR LTBP2 LMOD2

6.45e-0580794DOID:12930 (implicated_via_orthology)
DiseaseCetuximab response

ERBB2 EGFR

7.04e-055792cv:CN077967
DiseasePanitumumab response

ERBB2 EGFR

7.04e-055792cv:CN077999
DiseaseDisease Exacerbation

ERBB2 RAP1GAP EGFR CRYBG1 ABCC6

8.30e-05165795C0235874
Diseaseintestinal cancer (implicated_via_orthology)

ERBB2 ERBB4 EGFR

8.66e-0532793DOID:10155 (implicated_via_orthology)
DiseaseHead and Neck Neoplasms

ERBB2 EGFR CDC73

9.51e-0533793C0018671
DiseaseBiliary Tract Neoplasm

ERBB2 IDH2

1.05e-046792C0005426
DiseaseGLIOMA SUSCEPTIBILITY 1

ERBB2 IDH2

1.05e-046792C2750850
DiseaseAdenocarcinoma of large intestine

ERBB2 ERBB4 EGFR ZNRF3

1.31e-0496794C1319315
DiseaseNeoplasm of uncertain or unknown behavior of breast

ERBB2 ERBB4 HERC2

1.83e-0441793C0496956
DiseaseBreast adenocarcinoma

ERBB2 ERBB4 HERC2

1.83e-0441793C0858252
DiseaseMalignant Head and Neck Neoplasm

ERBB2 EGFR CDC73

2.26e-0444793C0278996
DiseaseGout

SLC2A9 ALPK1

2.52e-049792C0018099
Diseaselung adenocarcinoma (is_implicated_in)

ERBB2 ERBB4 EGFR

3.11e-0449793DOID:3910 (is_implicated_in)
Disease3-aminoisobutyrate measurement

SLC6A13 CDC73

4.59e-0412792EFO_0010980
DiseasePapilloma

ERBB2 EGFR

4.59e-0412792C0030354
DiseasePapillomatosis

ERBB2 EGFR

4.59e-0412792C0205875
DiseasePapilloma, Squamous Cell

ERBB2 EGFR

4.59e-0412792C0205874
Diseasethyroid gland carcinoma (is_marker_for)

CD93 ROBO4

4.59e-0412792DOID:3963 (is_marker_for)
Diseaseretinal vasculature measurement

USP2 ERBB4 ACO2 LAMA2 LTBP2 HERC2 MPPED2

4.75e-04517797EFO_0010554
DiseaseNeoplasm of lung

ERBB2 EGFR

6.31e-0414792cv:C0024121
DiseaseLung cancer

ERBB2 EGFR

6.31e-0414792cv:C0242379
DiseaseLUNG CANCER

ERBB2 EGFR

6.31e-0414792211980
Diseaseurate measurement

MPV17 USP2 ERBB4 CMIP SLC2A9 SLC25A30 IDH2 MPPED2 TECPR1

6.44e-04895799EFO_0004531
Diseasetransitional cell carcinoma (is_marker_for)

ERBB2 ERBB4 EGFR

6.53e-0463793DOID:2671 (is_marker_for)
Diseasecarcinoma (implicated_via_orthology)

ERBB2 ERBB4 EGFR

6.84e-0464793DOID:305 (implicated_via_orthology)
Diseasegout, hyperuricemia

SLC2A9 CNTN5

8.29e-0416792EFO_0004274, EFO_0009104
Diseasecardiomyopathy (implicated_via_orthology)

ERBB2 ERBB4 EGFR

9.26e-0471793DOID:0050700 (implicated_via_orthology)
Diseasemuscular dystrophy (is_implicated_in)

LAMA2 CAV3

9.38e-0417792DOID:9884 (is_implicated_in)
DiseaseAdrenocortical carcinoma

EGFR ZNRF3

1.05e-0318792C0206686
Diseasemuscular dystrophy (implicated_via_orthology)

LAMA2 CAV3

1.44e-0321792DOID:9884 (implicated_via_orthology)
DiseaseCarcinoma of lung

ERBB2 EGFR

1.73e-0323792C0684249
Diseasestomach carcinoma (is_marker_for)

ERBB2 ERBB4

1.88e-0324792DOID:5517 (is_marker_for)
Diseasealcohol use disorder (implicated_via_orthology)

ERBB2 ERBB4 EGFR PRKCG

1.89e-03195794DOID:1574 (implicated_via_orthology)
DiseaseMalignant neoplasm of breast

ERBB2 ERBB4 RAP1GAP EGFR IDO1 ACO2 LAMA2 HERC2 CNGA2

2.28e-031074799C0006142
DiseasePancreatic Neoplasm

RAP1GAP EGFR ZNRF3

2.48e-03100793C0030297
DiseaseMalignant neoplasm of pancreas

RAP1GAP EGFR ZNRF3

2.62e-03102793C0346647

Protein segments in the cluster

PeptideGeneStartEntry
YGVGFWKPGSGIIHQ

ACO2

161

Q99798
IAWQGDYGEFVIKDP

ERFL

61

A0A1W2PQ73
IAWQGDYGEFVIKDP

ERF

46

P50548
FGTVYKGIWIPDGEN

ERBB2

731

P04626
SGAFGTVYKGIWVPE

ERBB4

726

Q15303
KGVYVPYTQGKWEGE

BACE1

126

P56817
FYELVSGQWQVTGPG

BTNL3

11

Q6UXE8
FKELEFLGWYTTGGP

COPS6

116

Q7L5N1
VVWGTGKEGQPREYY

CDC73

41

Q6P1J9
LKGFSWVGGGEDTPY

CD93

111

Q9NPY3
GKDGWFQLYSPGGVA

CMIP

521

Q8IY22
ERRPEGGYKAVWFGE

CDHR5

781

Q9HBB8
GGYKAVWFGEDIGTE

CDHR5

786

Q9HBB8
WVTGNGKGLIYLTDP

ALPK1

1181

Q96QP1
ESLGRPQGFEVGYWK

CNTN5

901

O94779
HVFVWGYGILGKGPN

RCC1L

356

Q96I51
NGIWGVDPKDGVPYE

AOAH

231

P28039
EVTVKGFRIYGAPWT

MPPED2

166

Q15777
YGKPVDVWGCGVILF

CASK

196

O14936
GWKGNPQLSDGLVYE

IDO1

236

P14902
EWGQYVDLPKGFAVS

ISOC1

76

Q96CN7
AKYGQGEGPIWLDNV

LOXL4

86

Q96JB6
IQVEGYWIAVGDKEP

MDN1

1036

Q9NU22
DGGFWTVIDGKVYDI

HERC2

1221

O95714
GGKWTFSYIGFPVEL

IL17RB

116

Q9NRM6
QEGYDGGPNLRTKVW

LMOD2

366

Q6P5Q4
GEYQEPGGNVKGVWA

BEX5

26

Q5H9J7
VPEAQNGWLYGKLEG

BAIAP2L2

356

Q6UXY1
KFVPGAWLAGEGVDV

PRF1

36

P14222
FLWDVGSGVGRVEYP

LAMA2

2206

P24043
FGVSELLKAPVDGWY

PRKCG

261

P05129
GAPGTYNWKGIVRVE

ITGA6

206

P23229
IEKGPQYGSLERAWG

PACSIN1

71

Q9BY11
GEEGYPGELKVWVTY

GALM

136

Q96C23
GAFGTVYKGLWIPEG

EGFR

721

P00533
GSGVKEWEVYNFPAG

IDH2

201

P48735
WKPFVYGGLASITAE

SLC25A30

6

Q5SVS4
GDSGQPVDWFVVYKL

DNASE2

21

O00115
KVEGGTWAVYERPNF

CRYGS

41

P22914
PDTYNLVWRAGKDGG

CDON

591

Q4KMG0
VGDTFLYLPGWTKGQ

GLB1L

551

Q6UWU2
VGYGNRSDVPFWAIK

CTSF

436

Q9UBX1
APGGEYFVEGETWNI

CRIM1

681

Q9NZV1
DNFTLVPVWGKEGYL

BTD

401

P43251
AEPVGTYSFDGVWKV

CAV3

46

P56539
GKGYIPVEGAWTFGQ

LTBP2

1466

Q14767
FQGKKYDGPEVDVWS

MARK2

221

Q7KZI7
QTTGGFYPLIGWKIG

GK5

311

Q6ZS86
GKESTWPYLFGVIVV

SLC2A9

226

Q9NRM0
GIWVAYEKPGFTGHQ

CRYBG1

1271

Q9Y4K1
NIWVLDYFGGPKIVT

CREG1

196

O75629
ATGVFLKSWVYQPGE

PPP1R15A

381

O75807
GVLYTWDFGDGSPVL

PKD1

1156

P98161
GSSAKWVGPFYIGDR

NYNRIN

1841

Q9P2P1
GNPKTVGFYLGTWRD

TRMT2B

166

Q96GJ1
KIIAPWIGGVGYSSF

SLC6A16

176

Q9GZN6
VVGYWPKATGTNREG

TMEM200C

71

A6NKL6
YQLVDGGRFTLWGPE

TADA2B

51

Q86TJ2
AGWPAGKDSIQYGRV

ABCC6

916

O95255
HENGPFVLYGIVSWG

OVCH1

771

Q7RTY7
RILGGSQVEKGSYPW

OVCH2

51

Q7RTZ1
ILLPQFGGYWIEGTN

RAP1GAP

46

P47736
ELPWKSGQGDLAVYV

SLC9A5

761

Q14940
FVGPVVGGWYKVLDR

MPV17

61

P39210
VGGWYKVLDRFIPGT

MPV17

66

P39210
DKNWFYKEDVAGGPG

ODF3L1

186

Q8IXM7
YFEFKIQSTGIWGIG

SPRYD7

66

Q5W111
GGLHWGQDYEFKVRP

ROBO4

311

Q8WZ75
ISKSIGFGVDTWVYP

CNGA2

296

Q16280
WKPFVYGGLASIVAE

SLC25A14

41

O95258
PKDFATLYQGWGVSG

ZNF516

1066

Q92618
LGLFYEAGTKIDVPW

RNLS

196

Q5VYX0
EAGTKIDVPWAGQYI

RNLS

201

Q5VYX0
ENFGGEPTEKGGWTY

TECPR1

126

Q7Z6L1
FDEYWTLIGGITGPI

S100A16

76

Q96FQ6
AGEIIGLGNVWRFPY

SLC6A13

46

Q9NSD5
AAPYGGWEGQATFKL

WBP2NL

101

Q6ICG8
ATTVVEWFYRPEGGK

SCN3B

56

Q9NY72
KRILAPYVGGWGETN

PKHD1L1

2686

Q86WI1
PYVGGWGETNGAVIK

PKHD1L1

2691

Q86WI1
KGANVSWEPGFDGGY

IGSF9

521

Q9P2J2
YEYGWVGVVKLEQPE

ZNRF3

116

Q9ULT6
VVFRSPGGVHWGYEE

ZSCAN29

401

Q8IWY8
IGRYTLWETGKGQAP

USP2

231

O75604
TWNFLQSIYGGGPEV

USP33

901

Q8TEY7
SIVVKGYNIWTGGPD

TLE6

426

Q9H808
FWQVDHIKPVYGGGG

ZRANB3

1016

Q5FWF4